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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

INTS8 Gene

protein-coding   GIFtS: 50
GCID: GC08P095825

Integrator Complex Subunit 8

(Previous name: chromosome 8 open reading frame 52)
(Previous symbol: C8orf52)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Integrator Complex Subunit 81 2
C8orf521 2 3
Protein Kaonashi-12 3
Chromosome 8 Open Reading Frame 521
INT82
Int83

External Ids:    HGNC: 260481   Entrez Gene: 556562   Ensembl: ENSG000001649417   OMIM: 6113515   UniProtKB: Q75QN23   

Export aliases for INTS8 gene to outside databases

Previous GC identifers: GC08P095906 GC08P091043


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for INTS8 Gene:
This gene encodes a subunit of the Integrator complex which is involved in the cleavage of small nuclear RNAs U1
and U2 within the nucleus. The encoded protein associates with RNA polymerase II and is recruited to the U1 and
U2 small nuclear RNA genes. Alternative splicing results in multiple transcript variants. (provided by RefSeq,
Nov 2012)

GeneCards Summary for INTS8 Gene: 
INTS8 (integrator complex subunit 8) is a protein-coding gene. Diseases associated with INTS8 include familial lipoprotein lipase deficiency, and dysembryoplastic neuroepithelial tumor. GO annotations related to this gene include protein binding.

UniProtKB/Swiss-Prot: INT8_HUMAN, Q75QN2
Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2
transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal
domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes

Gene Wiki entry for INTS8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.2  NT_008046.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the INTS8 gene promoter:
         TBP   p53   FOXO3   FOXO3b   c-Rel   E2F   E2F-1   TFIID   Chx10   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidINTS8 promoter sequence
   Search SABiosciences Chromatin IP Primers for INTS8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INTS8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22.1   Ensembl cytogenetic band:  8q22.1   HGNC cytogenetic band: 8q22.1

INTS8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INTS8 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P095825:  view genomic region     (about GC identifiers)

Start:
95,825,539 bp from pter      End:
95,893,974 bp from pter
Size:
68,436 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: INT8_HUMAN, Q75QN2 (See protein sequence)
Recommended Name: Integrator complex subunit 8  
Size: 995 amino acids; 113088 Da
Subunit: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5,
INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAH50536.1; Type=Frameshift; Positions=985; Sequence=BAA91238.1; Type=Erroneous
initiation; Sequence=BAA91671.1; Type=Erroneous initiation;
Secondary accessions: B2RN92 Q5RKZ3 Q6P1R5 Q7Z314 Q9NVS6 Q9NWY7
Alternative splicing: 2 isoforms:  Q75QN2-1   Q75QN2-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for INTS8: NX_Q75QN2

Explore proteomics data for INTS8 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q75QN2

  • INTS8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    INTS8 Protein Expression
    REFSEQ proteins: NP_060334.2  
    ENSEMBL proteins: 
     ENSP00000429340   ENSP00000430033   ENSP00000430049   ENSP00000428260   ENSP00000429056  
     ENSP00000427840   ENSP00000430338   ENSP00000343274   ENSP00000429452   ENSP00000430180  
     ENSP00000430722   ENSP00000398203  

    Human Recombinant Protein Products for INTS8: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for INTS8 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032039integrator complex IDA16239144

    INTS8 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q75QN2

    UniProtKB/Swiss-Prot: INT8_HUMAN, Q75QN2
    Similarity: Contains 4 TPR repeats


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: INT8_HUMAN, Q75QN2
    Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2
    transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal
    domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16239144
         
    INTS8 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for INTS8 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for INTS8 
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    hsa-miR-200c hsa-miR-429 hsa-miR-3924 hsa-miR-200b hsa-miR-452
    SwitchGear 3'UTR luciferase reporter plasmidINTS8 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTS8


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for INTS8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/566 Interacting proteins for INTS8 (Q75QN22, 3 ENSP000003432744) via UniProtKB, MINT, STRING, and/or I2D (see all 566)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    INTS6Q9UL032, 3, ENSP000003102604MINT-7947479 I2D: score=1 STRING: ENSP00000310260
    INTS1Q8N2012, 3, ENSP000003857224MINT-7947479 I2D: score=1 STRING: ENSP00000385722
    INTS3Q68E012, 3, ENSP000003186414MINT-7947479 I2D: score=1 STRING: ENSP00000318641
    INTS5Q6P9B93, ENSP000003278894I2D: score=1 STRING: ENSP00000327889
    CDC5LQ994592, ENSP000003605324MINT-7947479 STRING: ENSP00000360532
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016180snRNA processing IDA16239144

    INTS8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    INTS8 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for INTS8 (INT8)

    2 Novoseek inferred chemical compound relationships for INTS8 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ethylene 29.2 2 12898689 (1), 15535724 (1)
    hydrogen 16.5 2 11703123 (1), 12739979 (1)

    Search CenterWatch for drugs/clinical trials and news about INTS8 / INT8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for INTS8 gene: 
    NM_017864.3  

    Unigene Cluster for INTS8:

    Integrator complex subunit 8
    Hs.727669  [show with all ESTs]
    Unigene Representative Sequence: NR_073444
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000522171 ENST00000523808 ENST00000521860 ENST00000519457 ENST00000519053
    ENST00000524333 ENST00000523731(uc003yhb.3 uc010mba.3) ENST00000523321(uc003yha.1)
    ENST00000343161(uc011lgq.2) ENST00000523206(uc011lgr.2) ENST00000520526
    ENST00000520845 ENST00000520315 ENST00000517918 ENST00000520853 ENST00000519736
    ENST00000521155 ENST00000522261
    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate INTS8:
    hsa-miR-200c hsa-miR-429 hsa-miR-3924 hsa-miR-200b hsa-miR-452
    SwitchGear 3'UTR luciferase reporter plasmidINTS8 3' UTR sequence
    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INTS8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INTS8
    Sirion Biotech Customized lentivirus for stable overexpression of INTS8 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INTS8
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INTS8

    Additional mRNA sequence: 

    AB161944.1 AK000537.1 AK001403.1 AK091278.1 AK225533.1 BC050536.1 BC064915.1 BC099915.1 
    BC136754.1 BC144396.1 BC144397.1 BX538203.1 NR_073444.1 NR_073445.1 

    16 DOTS entries:

    DT.95292667  DT.100809445  DT.100818699  DT.40111765  DT.410167  DT.121467002  DT.99972219  DT.448903 
    DT.100818698  DT.121466936  DT.92436546  DT.91651262  DT.92436556  DT.95292670  DT.91641834  DT.91743925 

    24/93 AceView cDNA sequences (see all 93):

    AA361674 AI094716 BX098825 AA430368 AA436738 BX279557 AF112857 BU754368 
    AL710946 AF102778 AA731030 AL597513 AA769139 BC020729 AF106690 AA430417 
    BC007015 AA215483 AI361383 BF691516 AF091433 BX482908 BU155934 BX475306 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for INTS8 (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                      -                                                                     
    SP5:                          -                                                                                                                                 

    ExUns: 17a · 17b ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b
    SP1:        -                 -                       -                                                   
    SP2:        -                 -                       -                 -                                 
    SP3:                                                                                                      
    SP4:                                                                                                      
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for INTS8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    INTS8 expression in normal human tissues (normalized intensities)      INTS8 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGCTATGGA
    INTS8 Expression
    About this image


    INTS8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Limb (Muscoskeletal System)
             Limb Bud
     
     Eye (Sensory Organs)
             GABAergic Amacrine Cells Inner Nuclear Layer

    See INTS8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for INTS8

    SOURCE GeneReport for Unigene cluster: Hs.727669
        SABiosciences Custom PCR Arrays for INTS8
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INTS8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTS8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for INTS8 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ints81 , 5 integrator complex subunit 81, 5 89.68(n)1
    95.78(a)1
      4 (5.08 cM)5
    726561  NM_001159595.11  NP_001153067.11 
     111991585 
    chicken
    (Gallus gallus)
    Aves INTS81 integrator complex subunit 8 78.76(n)
    89.45(a)
      420230  NM_001040228.2  NP_001035318.1 
    lizard
    (Anolis carolinensis)
    Reptilia INTS86
    Uncharacterized protein
    87(a)
    1 ↔ 1
    4(19305513-19329180)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.192142 Transcribed sequence with moderate similarity to protein refNP_060334.1 (H.sapiens) hypothetical protein FLJ20530 [Homo sapiens] less 74.17(n)    142010475 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.34902 Transcribed sequence with moderate similarity to protein refNP_060334.1 (H.sapiens) hypothetical protein FLJ20530 [Homo sapiens] less 73.03(n)    57040653 
    fruit fly
    (Drosophila melanogaster)
    Insecta IntS81 Integrator 8 41.16(n)
    30.13(a)
      36886  NM_137318.2  NP_611162.2 


    ENSEMBL Gene Tree for INTS8 (if available)
    TreeFam Gene Tree for INTS8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1280 SNPs in INTS8 are shown (see all 1280)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1902054571,2
    --95833572(+) GGGAAA/CGATGT 3 -- us2k10--------
    rs1500942761,2
    --95833605(+) AAACTC/TGGCCA 3 -- us2k10--------
    rs785202441,2
    C,F--95833691(+) ACATAC/TTGCTC 3 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1383575841,2
    --95833721(+) AGATGC/TGACTC 3 -- us2k10--------
    rs40758341,2
    C,F,A,H--95833747(+) gacacC/Tggacc 3 -- us2k121Minor allele frequency- T:0.13NS EA NA WA CSA 1982
    rs40758351,2
    C,F,A,H--95833822(+) TACCAC/TTGCCA 3 -- us2k115Minor allele frequency- T:0.43NS EA NA WA CSA 798
    rs1492742521,2
    C--95833874(+) CCCGAC/TGACCC 3 -- us2k10--------
    rs1824447271,2
    --95833918(+) ATAAAC/TTTCCC 3 -- us2k10--------
    rs1866347611,2
    --95833994(+) TCAGCA/GCACTG 3 -- us2k10--------
    rs1906081931,2
    --95834035(+) GTCACA/CGAGCT 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for INTS8 (95825539 - 95893974 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for INTS8:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv6314CNV Insertion18451855
    dgv7835n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611351    OMIM disorders: --

    11 diseases for INTS8:    About MalaCards
    familial lipoprotein lipase deficiency    dysembryoplastic neuroepithelial tumor    lipoprotein lipase deficiency    cocaine abuse
    cocaine dependence    acute lymphoblastic leukemia    crohn's disease    lymphoblastic leukemia
    myocardial infarction    alcoholism    leukemia

    3 diseases from the University of Copenhagen DISEASES database for INTS8:
    Cocaine abuse     Cocaine dependence     Familial lipoprotein lipase deficiency

    INTS8 for disorders           About GeneDecksing

    Genetic Association Database (GAD): INTS8
    Human Genome Epidemiology (HuGE) Navigator: INTS8 (1 document)

    Export disorders for INTS8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for INTS8 gene, integrated from 9 sources (see all 60):
    (articles sorted by number of sources associating them with INTS8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PubMed id 16239144)1, 2, 3 Baillat D....Shiekhattar R. (2005)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. Streamlined analysis schema for high-throughput ident ification of endogenous protein complexes. (PubMed id 20133760)1 Malovannaya A....Qin J. (2010)
    10. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55656 HGNC: 26048 AceView: CCNE2 Ensembl:ENSG00000164941 euGenes: HUgn55656
    ECgene: INTS8 H-InvDB: INTS8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for INTS8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for INTS8 gene:
    Search GeneIP for patents involving INTS8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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