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Aliases for INTS8 Gene

Aliases for INTS8 Gene

  • Integrator Complex Subunit 8 2 3 5
  • Protein Kaonashi-1 3 4
  • C8orf52 3 4
  • INT8 3 4
  • Chromosome 8 Open Reading Frame 52 2

External Ids for INTS8 Gene

Previous HGNC Symbols for INTS8 Gene

  • C8orf52

Previous GeneCards Identifiers for INTS8 Gene

  • GC08P095906
  • GC08P091043
  • GC08P095825

Summaries for INTS8 Gene

Entrez Gene Summary for INTS8 Gene

  • This gene encodes a subunit of the Integrator complex which is involved in the cleavage of small nuclear RNAs U1 and U2 within the nucleus. The encoded protein associates with RNA polymerase II and is recruited to the U1 and U2 small nuclear RNA genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

GeneCards Summary for INTS8 Gene

INTS8 (Integrator Complex Subunit 8) is a Protein Coding gene. Among its related pathways are RNA polymerase II transcribes snRNA genes and Gene Expression.

UniProtKB/Swiss-Prot for INTS8 Gene

  • Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.

Gene Wiki entry for INTS8 Gene

Additional gene information for INTS8 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INTS8 Gene

Genomics for INTS8 Gene

Regulatory Elements for INTS8 Gene

Enhancers for INTS8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H094718 1.2 ENCODE 66.7 -93.2 -93230 2 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC ZC3H11A VIRMA RBM12B INTS8 C8orf37 ENSG00000254283 LINC01298 PSMA2P2 NDUFAF6 RPL34P18 TMEM67
GH08H094904 1.2 Ensembl ENCODE 53 +93.0 92959 3 HDGF FOXA2 ARID4B YBX1 YY1 ZNF143 ATF7 RUNX3 CAVIN1 REST INTS8 VIRMA TP53INP1 ENSG00000253878 NDUFAF6 CCNE2
GH08H095267 1.2 ENCODE 51 +456.2 456237 3 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 VIRMA INTS8 C8orf37 ENSG00000272509 ENSG00000253704 ENSG00000253878 MTERF3 TRS-AGA2-5 LINC01298
GH08H094638 1.5 Ensembl ENCODE dbSUPER 38.7 -172.4 -172447 5 HDGF PKNOX1 SIN3A ZNF2 ZBTB7B ETS1 GLIS2 ELK1 ZNF207 FOS INTS8 VIRMA RBM12B LOC100288748 ENSG00000253878 ESRP1
GH08H093871 1.5 Ensembl ENCODE dbSUPER 24.5 -939.1 -939099 4 ATF1 ZNF133 FEZF1 ZNF766 ELK1 FOS ATF7 SP3 CAVIN1 TSHZ1 VIRMA RBM12B INTS8 GC08M093861 LOC105375646
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around INTS8 on UCSC Golden Path with GeneCards custom track

Genomic Location for INTS8 Gene

Chromosome:
8
Start:
94,813,311 bp from pter
End:
94,881,746 bp from pter
Size:
68,436 bases
Orientation:
Plus strand

Genomic View for INTS8 Gene

Genes around INTS8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INTS8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INTS8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INTS8 Gene

Proteins for INTS8 Gene

  • Protein details for INTS8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q75QN2-INT8_HUMAN
    Recommended name:
    Integrator complex subunit 8
    Protein Accession:
    Q75QN2
    Secondary Accessions:
    • B2RN92
    • Q5RKZ3
    • Q6P1R5
    • Q7Z314
    • Q9NVS6
    • Q9NWY7

    Protein attributes for INTS8 Gene

    Size:
    995 amino acids
    Molecular mass:
    113088 Da
    Quaternary structure:
    • Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.
    SequenceCaution:
    • Sequence=AAH50536.1; Type=Frameshift; Positions=985; Evidence={ECO:0000305}; Sequence=BAA91238.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91671.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for INTS8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for INTS8 Gene

Post-translational modifications for INTS8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for INTS8 Gene

Domains & Families for INTS8 Gene

Gene Families for INTS8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for INTS8 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for INTS8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q75QN2

UniProtKB/Swiss-Prot:

INT8_HUMAN :
  • Belongs to the Integrator subunit 8 family.
Family:
  • Belongs to the Integrator subunit 8 family.
genes like me logo Genes that share domains with INTS8: view

Function for INTS8 Gene

Molecular function for INTS8 Gene

UniProtKB/Swiss-Prot Function:
Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.

Phenotypes From GWAS Catalog for INTS8 Gene

Gene Ontology (GO) - Molecular Function for INTS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16239144
genes like me logo Genes that share ontologies with INTS8: view
genes like me logo Genes that share phenotypes with INTS8: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for INTS8
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for INTS8 Gene

Localization for INTS8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for INTS8 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for INTS8 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for INTS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0032039 integrator complex IDA 16239144
genes like me logo Genes that share ontologies with INTS8: view

Pathways & Interactions for INTS8 Gene

genes like me logo Genes that share pathways with INTS8: view

Pathways by source for INTS8 Gene

2 Reactome pathways for INTS8 Gene

Gene Ontology (GO) - Biological Process for INTS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016180 snRNA processing IDA 16239144
GO:0042795 snRNA transcription from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with INTS8: view

No data available for SIGNOR curated interactions for INTS8 Gene

Drugs & Compounds for INTS8 Gene

(1) Drugs for INTS8 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for INTS8 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with INTS8: view

Transcripts for INTS8 Gene

Unigene Clusters for INTS8 Gene

Integrator complex subunit 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for INTS8
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for INTS8 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^
SP1:
SP2:
SP3:
SP4: -
SP5: -
SP6:
SP7: - - -
SP8:
SP9: - - -
SP10:

ExUns: 17a · 17b ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b
SP1: - - -
SP2: - - - -
SP3:
SP4:
SP5:
SP6: - - - -
SP7:
SP8:
SP9:
SP10:

Relevant External Links for INTS8 Gene

GeneLoc Exon Structure for
INTS8
ECgene alternative splicing isoforms for
INTS8

Expression for INTS8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for INTS8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for INTS8 Gene

This gene is overexpressed in Adipocyte (17.0), Liver (11.0), and Urinary Bladder (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for INTS8 Gene



Protein tissue co-expression partners for INTS8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of INTS8 Gene:

INTS8

SOURCE GeneReport for Unigene cluster for INTS8 Gene:

Hs.727669

Evidence on tissue expression from TISSUES for INTS8 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with INTS8: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for INTS8 Gene

Orthologs for INTS8 Gene

This gene was present in the common ancestor of animals.

Orthologs for INTS8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INTS8 33 34
  • 99.5 (n)
dog
(Canis familiaris)
Mammalia INTS8 33 34
  • 94.15 (n)
oppossum
(Monodelphis domestica)
Mammalia INTS8 34
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 93 (a)
OneToMany
-- 34
  • 86 (a)
OneToMany
cow
(Bos Taurus)
Mammalia INTS8 33 34
  • 92.9 (n)
mouse
(Mus musculus)
Mammalia Ints8 33 16 34
  • 89.72 (n)
chicken
(Gallus gallus)
Aves INTS8 33 34
  • 78.76 (n)
lizard
(Anolis carolinensis)
Reptilia INTS8 34
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ints8 33
  • 73.53 (n)
Str.19214 33
zebrafish
(Danio rerio)
Actinopterygii ints8 33 34
  • 67 (n)
Dr.3490 33
fruit fly
(Drosophila melanogaster)
Insecta IntS8 33 34
  • 41.72 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011449 33
  • 21.28 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 28 (a)
OneToOne
Species where no ortholog for INTS8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for INTS8 Gene

ENSEMBL:
Gene Tree for INTS8 (if available)
TreeFam:
Gene Tree for INTS8 (if available)

Paralogs for INTS8 Gene

No data available for Paralogs for INTS8 Gene

Variants for INTS8 Gene

Sequence variations from dbSNP and Humsavar for INTS8 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs796052157 Likely benign 94,827,759(+) CAGTC(A/C)AACAG nc-transcript-variant, reference, missense, utr-variant-5-prime
rs193920861 Uncertain significance 94,824,927(+) TTTTT(-/G)GAACA intron-variant, nc-transcript-variant, reference, frameshift-variant, utr-variant-5-prime
rs1000049769 -- 94,877,354(+) AATAT(A/G)TGCCC intron-variant
rs1000086081 -- 94,836,955(+) ATTTA(C/T)TTCAT intron-variant
rs1000096600 -- 94,822,324(+) AGACA(-/G)GGTCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for INTS8 Gene

Variant ID Type Subtype PubMed ID
nsv6314 CNV insertion 18451855

Variation tolerance for INTS8 Gene

Residual Variation Intolerance Score: 7.26% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.05; 37.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for INTS8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
INTS8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INTS8 Gene

Disorders for INTS8 Gene

Relevant External Links for INTS8

Genetic Association Database (GAD)
INTS8
Human Genome Epidemiology (HuGE) Navigator
INTS8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
INTS8

No disorders were found for INTS8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for INTS8 Gene

Publications for INTS8 Gene

  1. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PMID: 16239144) Baillat D … Shiekhattar R (Cell 2005) 2 3 4 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for INTS8 Gene

Sources for INTS8 Gene

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