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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

INTS8 Gene

protein-coding GIFtS: 48
GCID: GC08P095825

integrator complex subunit 8

(Previous name: chromosome 8 open reading frame 52 )
(Previous symbol: C8orf52)

Explore 11 diseases affiliated with
INTS8 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Integrator Complex Subunit 8¹ ²		FLJ20530¹
C8orf52¹ ² ³		MGC131633¹
INT8¹ ²		Chromosome 8 Open Reading Frame 52¹
Protein Kaonashi-1² ³		Int8³

External Ids:	HGNC: 26048¹	Entrez Gene: 55656²	Ensembl: ENSG00000164941⁷	OMIM: 611351⁵	UniProtKB: Q75QN2³

Export aliases for INTS8 gene to outside databases

Previous GC identifers: GC08P095906 GC08P091043

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for INTS8:

This gene encodes a subunit of the Integrator complex which is involved in the cleavage of small nuclear RNAs U1 and U2

within the nucleus. The encoded protein associates with RNA polymerase II and is recruited to the U1 and U2 small

nuclear RNA genes. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Nov 2012)

UniProtKB/Swiss-Prot: INT8_HUMAN, Q75QN2

Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2

transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal

domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes

Gene Wiki entry for INTS8

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_008046.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the INTS8 gene promoter:
TBP p53 FOXO3 FOXO3b c-Rel E2F E2F-1 TFIID Chx10 FOXO3a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: INTS8 promoter sequence

Search SABiosciences Chromatin IP Primers for INTS8

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INTS8

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22.1 Ensembl cytogenetic band: 8q22.1 HGNC cytogenetic band: 8q22.1

INTS8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INTS8 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P095825: view genomic region (about GC identifiers)

Start:	95,825,539 bp from pter	End:	95,893,974 bp from pter
Size:	68,436 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: INT8_HUMAN, Q75QN2 (See protein sequence)

Recommended Name: Integrator complex subunit 8

Size: 995 amino acids; 113088 Da

Subunit: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6,

INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12

Subcellular location: Nucleus (Probable)

Sequence caution: Sequence=AAH50536.1; Type=Frameshift; Positions=985; Sequence=BAA91238.1; Type=Erroneous initiation;

Sequence=BAA91671.1; Type=Erroneous initiation;

Secondary accessions: B2RN92 Q5RKZ3 Q6P1R5 Q7Z314 Q9NVS6 Q9NWY7

Alternative splicing: 2 isoforms: Q75QN2-1 Q75QN2-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for INTS8: NX_Q75QN2

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q75QN2

INTS8 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_060334.2

ENSEMBL proteins:

ENSP00000429340 ENSP00000430033 ENSP00000430049 ENSP00000428260 ENSP00000429056

ENSP00000427840 ENSP00000430338 ENSP00000343274 ENSP00000429452 ENSP00000430180

ENSP00000430722 ENSP00000398203

Human Recombinant Protein Products for INTS8:

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	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for INTS8
	GenScript Custom Purified and Recombinant Proteins Services for INTS8
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for INTS8

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0032039	integrator complex	IDA	16239144

INTS8 for ontologies About GeneDecksing

INTS8 Antibody Products:

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	Novus Biologicals INTS8 Antibody
	Abcam antibodies for INTS8
	Uscn Antibodies for INTS8
	Search ThermoFisher Antibodies for INTS8

Assay Products for INTS8:

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	GenScript Custom Assay Services for INTS8
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for INTS8

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q75QN2

UniProtKB/Swiss-Prot: INT8_HUMAN, Q75QN2

Similarity: Contains 4 TPR repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: INT8_HUMAN, Q75QN2

Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2

transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal

domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	16239144

INTS8 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for INTS8

miRNA Products:		OriGene 3'-UTR Clone: INTS8 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat INTS8
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate INTS8:
		hsa-miR-200c hsa-miR-429 hsa-miR-3924 hsa-miR-200b hsa-miR-452
		SwitchGear 3'UTR luciferase reporter plasmid: INTS8 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for INTS8 (see all 4) OriGene shRNA RFP: INTS8 Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat INTS8
		Sirion Biotech Custom design and validation of potent shRNA sequences against INTS8

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for INTS8
			Sirion Biotech Customized adenovirus for overexpression of INTS8 Sirion Biotech Customized adenovirus for potent knockdown of INTS8

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for INTS8 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for INTS8 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: INTS8 (NM_017864)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for INTS8
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INTS8

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for INTS8
		Search LifeMap BioReagents cell lines for INTS8
		Sirion Biotech Customized stable knockdown cell line services for INTS8 Sirion Biotech Customized inducible knockdown cell line services for INTS8 Sirion Biotech Customized stable overexpressing cell line services for INTS8 Sirion Biotech Customized inducible overexpressing cell line services for INTS8

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTS8

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for INTS8

STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

5/539 Interacting proteins for INTS8 (Q75QN2^{2, 3} ENSP00000343274⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 539)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
INTS6	Q9UL03²^,³, ENSP00000310260⁴	MINT-7947479 I2D: score=1 STRING: ENSP00000310260
INTS1	Q8N201²^,³, ENSP00000385722⁴	MINT-7947479 I2D: score=1 STRING: ENSP00000385722
INTS3	Q68E01²^,³, ENSP00000318641⁴	MINT-7947479 I2D: score=1 STRING: ENSP00000318641
INTS5	Q6P9B9³, ENSP00000327889⁴	I2D: score=1 STRING: ENSP00000327889
CDC5L	Q99459², ENSP00000360532⁴	MINT-7947479 STRING: ENSP00000360532

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016180	snRNA processing	IDA	16239144

INTS8 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

INTS8 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for INTS8
2 Novoseek chemical compound relationships for INTS8 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ethylene	29.2	2	12898689 (1), 15535724 (1)
hydrogen	16.5	2	11703123 (1), 12739979 (1)

Search CenterWatch for drugs/clinical trials and news about INTS8 / INT8

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for INTS8 gene:

NM_017864.3

Unigene Cluster for INTS8:

Integrator complex subunit 8

Hs.727669 [show with all ESTs]

Unigene Representative Sequence: NR_073444

18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):

ENST00000522171 ENST00000523808 ENST00000521860 ENST00000519457 ENST00000519053

ENST00000524333 ENST00000523731(uc003yhb.3 uc010mba.3) ENST00000523321(uc003yha.1)

ENST00000343161(uc011lgq.2) ENST00000523206(uc011lgr.2) ENST00000520526

ENST00000520845 ENST00000520315 ENST00000517918 ENST00000520853 ENST00000519736

ENST00000521155 ENST00000522261

miRNA Products:		OriGene 3'-UTR Clone: INTS8 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat INTS8
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate INTS8:
		hsa-miR-200c hsa-miR-429 hsa-miR-3924 hsa-miR-200b hsa-miR-452
		SwitchGear 3'UTR luciferase reporter plasmid: INTS8 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for INTS8 (see all 4) OriGene shRNA RFP: INTS8 Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat INTS8
		Sirion Biotech Custom design and validation of potent shRNA sequences against INTS8

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for INTS8 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for INTS8 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: INTS8 (NM_017864)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for INTS8
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INTS8

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for INTS8 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat INTS8
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INTS8
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INTS8

Additional cDNA sequence:

AB161944.1 AK000537.1 AK001403.1 AK091278.1 AK225533.1 BC050536.1 BC064915.1 BC099915.1

BC136754.1 BC144396.1 BC144397.1 BX538203.1 NR_073444.1 NR_073445.1

16 DOTS entries:

DT.95292667 DT.100809445 DT.100818699 DT.40111765 DT.410167 DT.121467002 DT.99972219 DT.448903

DT.100818698 DT.121466936 DT.92436546 DT.91651262 DT.92436556 DT.95292670 DT.91641834 DT.91743925

24/93 AceView cDNA sequences (see all 93):

AA215483 BX098825 AA769139 AF106690 BC020729 AA731030 BX279557 AL710946

AA361674 AF102778 AL597513 AA436738 AA430417 AA430368 BC007015 BU754368

AF112857 AI094716 NM_004702 AW769873 BE501854 AV718083 AA215482 BX506606

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for INTS8 (see all 10) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3	^	4a	·	4b	·	4c	^	5	^	6a	·	6b	^	7a	·	7b	^	8	^	9a	·	9b	·	9c	^	10	^	11	^	12	^	13	^	14a	·	14b	^	15a	·	15b	^	16	^
SP1:
SP2:
SP3:
SP4:																													-
SP5:									-

ExUns:	17a	·	17b	^	18	^	19	^	20a	·	20b	^	21a	·	21b	^	22	^	23	^	24	^	25	^	26	^	27	^	28	^	29a	·	29b
SP1:			-						-								-
SP2:			-						-								-						-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for INTS8

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

INTS8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGCTATGGA

About this image

INTS8 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Cap Mesenchyme

Cap Mesenchyme Cells

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See INTS8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for INTS8

SOURCE GeneReport for Unigene cluster: Hs.727669

SABiosciences Custom PCR Arrays for INTS8

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for INTS8 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INTS8
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INTS8

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTS8

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for INTS8 gene from 6/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ints8^{1 , 5}	integrator complex subunit 8^{1, 5}	89.68(n)¹ 95.78(a)¹		4 (5.08 cM)⁵ 72656¹ NM_001159595.1¹ NP_001153067.1¹ 11199158⁵
chicken (Gallus gallus)	Aves	INTS8¹	integrator complex subunit 8	78.76(n) 89.45(a)		420230 NM_001040228.2 NP_001035318.1
lizard (Anolis carolinensis)	Reptilia	INTS8⁶	--	87(a)	1 ↔ 1	4(19305513-19329180)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.19214²	Transcribed sequence with moderate similarity to protein more	74.17(n)		142010475
zebrafish (Danio rerio)	Actinopterygii	Dr.3490²	Transcribed sequence with moderate similarity to protein more	73.03(n)		57040653
fruit fly (Drosophila melanogaster)	Insecta	IntS8¹	Integrator 8	41.16(n) 30.13(a)		36886 NM_137318.2 NP_611162.2

ENSEMBL Gene Tree for INTS8 (if available)
TreeFam Gene Tree for INTS8 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs28399593^1,2	C,F	--	91098552(-)	`AAGCAT/CAGAAG`	1	--	int¹		3		NS WA NA	400
rs28399592^1,2	C,F	--	91098710(-)	`CATAGC/TGGGCT`	1	--	int¹		9		NS WA NA	1064
rs112055136^1,2		--	91098880(+)	`TCCACC/TTCCAG`	1	--	int¹		1		CSA	2
rs28399591^1,2	C	--	91099301(-)	`AAACCC/TGAAGT`	1	--	int¹		2		NS WA	280
rs28399590^1,2	C,F	--	91099643(-)	`TTTTGT/CATTTT`	1	--	int¹		1		NS	180
rs201815818^1,2	C	--	91099843(-)	`GATTTA/TAAAAA`	1	--	int¹		0	--	--	--	--
rs35421564^1,2	C	--	95836230(+)	`AAACA-/TTTTTT`	1	--	int¹		1		NA	2
rs34078782^1,2	C	--	95837013(+)	`AAACT-/CCCCCC`	1	--	int¹		1		NA	2
rs7459499^1,2	C,A,H	--	95837670(+)	`AAAAAA/TAATAA`	1	--	int¹		4		NA WA	8
rs202191433^1,2		--	95837670(+)	`AAAAA-/TAATAA`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for INTS8 (95825539 - 95893974 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for INTS8: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing INTS8

DNA2.0 Custom Variant and Variant Library Synthesis for INTS8

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

INTS8 for disorders           About GeneDecksing

OMIM gene information: 611351    OMIM disorders: --

11 diseases for INTS8:    About MalaCards

familial lipoprotein lipase deficiency lipoprotein lipase deficiency dysembryoplastic neuroepithelial tumor cocaine abuse

ventricular tachycardia acute lymphoblastic leukemia lymphoblastic leukemia myocardial infarction

crohn's disease leukemia alcoholism

3 diseases from the University of Copenhagen DISEASES database for INTS8:

Cocaine abuse Cocaine dependence Familial lipoprotein lipase deficiency

Human Genome Epidemiology (HuGE) Navigator: INTS8 (1 document)

Export disorders for INTS8 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for INTS8 gene, integrated from 9 sources (see all 60):
(articles sorted by number of sources associating them with INTS8)

Utopia: connect your pdf to the dynamic
world of online information

Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PubMed id 16239144)^{1, 2, 3} Baillat D....Shiekhattar R. (2005)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Streamlined analysis schema for high-throughput ident ification of endogenous protein complexes. (PubMed id 20133760)¹ Malovannaya A....Qin J. (2010)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 55656	HGNC: 26048	AceView: CCNE2	Ensembl:ENSG00000164941	euGenes: HUgn55656
ECgene: INTS8	H-InvDB: INTS8

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for INTS8	Pharmacogenomics, SNPs, Pathways

Intellectual Property for INTS8 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for INTS8 gene:
Search GeneIP for patents involving INTS8

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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INTS8 Gene

integrator complex subunit 8

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INTS8 Gene

integrator complex subunit 8

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Functionfor INTS8 gene

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for INTS8 gene

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for INTS8 gene

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for INTS8 gene

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Families
for INTS8 gene

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for INTS8 gene

Pathways & Interactions
for INTS8 gene

Drugs & Compounds
for INTS8 gene

Transcripts
for INTS8 gene

Expression
for INTS8 gene

Orthologs
for INTS8 gene

Paralogs
for INTS8 gene

Genomic Variants
for INTS8 gene

Disorders / Diseases
for INTS8 gene

Publications
for INTS8 gene

Intellectual Property
for INTS8 gene

Products
for INTS8 gene