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Aliases for INTS8 Gene

Aliases for INTS8 Gene

  • Integrator Complex Subunit 8 2 3
  • INT8 3 4 6
  • Protein Kaonashi-1 3 4
  • C8orf52 3 4
  • Chromosome 8 Open Reading Frame 52 2

External Ids for INTS8 Gene

Previous Symbols for INTS8 Gene

  • C8orf52

Summaries for INTS8 Gene

Entrez Gene Summary for INTS8 Gene

  • This gene encodes a subunit of the Integrator complex which is involved in the cleavage of small nuclear RNAs U1 and U2 within the nucleus. The encoded protein associates with RNA polymerase II and is recruited to the U1 and U2 small nuclear RNA genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

GeneCards Summary for INTS8 Gene

INTS8 (Integrator Complex Subunit 8) is a Protein Coding gene. Diseases associated with INTS8 include familial lipoprotein lipase deficiency and dysembryoplastic neuroepithelial tumor.

UniProtKB/Swiss-Prot for INTS8 Gene

  • Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes

Gene Wiki entry for INTS8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INTS8 Gene

Genomics for INTS8 Gene

Genomic Location for INTS8 Gene

Start:
94,813,311 bp from pter
End:
94,881,746 bp from pter
Size:
68,436 bases
Orientation:
Plus strand

Genomic View for INTS8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for INTS8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INTS8 Gene

Regulatory Elements for INTS8 Gene

Proteins for INTS8 Gene

  • Protein details for INTS8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q75QN2-INT8_HUMAN
    Recommended name:
    Integrator complex subunit 8
    Protein Accession:
    Q75QN2
    Secondary Accessions:
    • B2RN92
    • Q5RKZ3
    • Q6P1R5
    • Q7Z314
    • Q9NVS6
    • Q9NWY7

    Protein attributes for INTS8 Gene

    Size:
    995 amino acids
    Molecular mass:
    113088 Da
    Quaternary structure:
    • Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12.
    SequenceCaution:
    • Sequence=AAH50536.1; Type=Frameshift; Positions=985; Evidence={ECO:0000305}; Sequence=BAA91238.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91671.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for INTS8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for INTS8 Gene

Proteomics data for INTS8 Gene at MOPED

Post-translational modifications for INTS8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for INTS8 Gene

Domains for INTS8 Gene

Protein Domains for INTS8 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for INTS8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q75QN2

UniProtKB/Swiss-Prot:

INT8_HUMAN
Similarity:
  • Contains 4 TPR repeats.:
    • Q75QN2
genes like me logo Genes that share domains with INTS8: view

No data available for Gene Families for INTS8 Gene

Function for INTS8 Gene

Molecular function for INTS8 Gene

UniProtKB/Swiss-Prot Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes

Gene Ontology (GO) - Molecular Function for INTS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16239144
genes like me logo Genes that share ontologies with INTS8: view

miRNA for INTS8 Gene

miRTarBase miRNAs that target INTS8

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for INTS8 Gene

Localization for INTS8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for INTS8 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for INTS8 Gene COMPARTMENTS Subcellular localization image for INTS8 gene
Compartment Confidence
nucleus 4
cytosol 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for INTS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032039 integrator complex IDA 16239144
genes like me logo Genes that share ontologies with INTS8: view

Pathways for INTS8 Gene

SuperPathways for INTS8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for INTS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016180 snRNA processing IDA 16239144
genes like me logo Genes that share ontologies with INTS8: view

No data available for Pathways by source for INTS8 Gene

Compounds for INTS8 Gene

(2) Novoseek inferred chemical compound relationships for INTS8 Gene

Compound -log(P) Hits PubMed IDs
ethylene 29.2 2
hydrogen 16.5 2
genes like me logo Genes that share compounds with INTS8: view

Transcripts for INTS8 Gene

Unigene Clusters for INTS8 Gene

Integrator complex subunit 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for INTS8 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^
SP1:
SP2:
SP3:
SP4: -
SP5: -
SP6:
SP7: - - -
SP8:
SP9: - - -
SP10:

ExUns: 17a · 17b ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b
SP1: - - -
SP2: - - - -
SP3:
SP4:
SP5:
SP6: - - - -
SP7:
SP8:
SP9:
SP10:

Relevant External Links for INTS8 Gene

GeneLoc Exon Structure for
INTS8
ECgene alternative splicing isoforms for
INTS8

Expression for INTS8 Gene

mRNA expression in normal human tissues for INTS8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for INTS8 Gene

SOURCE GeneReport for Unigene cluster for INTS8 Gene Hs.727669

genes like me logo Genes that share expressions with INTS8: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for INTS8 Gene

Orthologs for INTS8 Gene

This gene was present in the common ancestor of animals.

Orthologs for INTS8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INTS8 35
  • 99.5 (n)
  • 99.36 (a)
INTS8 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia INTS8 35
  • 92.9 (n)
  • 98.77 (a)
INTS8 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia INTS8 35
  • 94.15 (n)
  • 98.25 (a)
INTS8 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ints8 35
  • 89.72 (n)
  • 95.78 (a)
Ints8 16
Ints8 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia INTS8 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 86 (a)
OneToMany
-- 36
  • 93 (a)
OneToMany
chicken
(Gallus gallus)
Aves INTS8 35
  • 78.76 (n)
  • 89.45 (a)
INTS8 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia INTS8 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ints8 35
  • 73.53 (n)
  • 80.42 (a)
Str.19214 35
zebrafish
(Danio rerio)
Actinopterygii Dr.3490 35
ints8 35
  • 67 (n)
  • 70.02 (a)
ints8 36
  • 70 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011449 35
  • 21.28 (n)
  • 3.76 (a)
fruit fly
(Drosophila melanogaster)
Insecta IntS8 35
  • 41.72 (n)
  • 30.76 (a)
IntS8 36
  • 25 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
OneToOne
Species with no ortholog for INTS8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for INTS8 Gene

ENSEMBL:
Gene Tree for INTS8 (if available)
TreeFam:
Gene Tree for INTS8 (if available)

Paralogs for INTS8 Gene

No data available for Paralogs for INTS8 Gene

Variants for INTS8 Gene

Sequence variations from dbSNP and Humsavar for INTS8 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs3378 -- 94,860,230(-) TGTAT(A/C)ATATT intron-variant
rs713113 -- 94,865,559(-) CGTCT(A/G)CTTTC synonymous-codon, reference, nc-transcript-variant
rs716733 -- 94,876,753(+) CTTAC(A/G)ATGGC intron-variant
rs1129152 -- 94,876,079(+) GTGGC(C/T)ATTTT reference, synonymous-codon, nc-transcript-variant
rs2053990 -- 94,871,350(-) caggc(A/G)ctcac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for INTS8 Gene

Variant ID Type Subtype PubMed ID
nsv6314 CNV Insertion 18451855
dgv7835n71 CNV Loss 21882294

Relevant External Links for INTS8 Gene

HapMap Linkage Disequilibrium report
INTS8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INTS8 Gene

Disorders for INTS8 Gene

(3) University of Copenhagen DISEASES for INTS8 Gene

Relevant External Links for INTS8

Genetic Association Database (GAD)
INTS8
Human Genome Epidemiology (HuGE) Navigator
INTS8
genes like me logo Genes that share disorders with INTS8: view

No data available for UniProtKB/Swiss-Prot for INTS8 Gene

Publications for INTS8 Gene

  1. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PMID: 16239144) Baillat D. … Shiekhattar R. (Cell 2005) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4

Products for INTS8 Gene

Sources for INTS8 Gene

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