Aliases for INTS8 Gene
External Ids for INTS8 Gene
Previous HGNC Symbols for INTS8 Gene
Previous GeneCards Identifiers for INTS8 Gene
This gene encodes a subunit of the Integrator complex which is involved in the cleavage of small nuclear RNAs U1 and U2 within the nucleus. The encoded protein associates with RNA polymerase II and is recruited to the U1 and U2 small nuclear RNA genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
GeneCards Summary for INTS8 Gene
INTS8 (Integrator Complex Subunit 8) is a Protein Coding gene. Among its related pathways are Gene Expression and Formation of HIV elongation complex in the absence of HIV Tat.
UniProtKB/Swiss-Prot for INTS8 Gene
Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.