Free for academic non-profit institutions. Other users need a Commercial license

Aliases for INTS7 Gene

Aliases for INTS7 Gene

  • Integrator Complex Subunit 7 2 3 5
  • C1orf73 3 4
  • INT7 3 4
  • Chromosome 1 Open Reading Frame 73 2

External Ids for INTS7 Gene

Previous HGNC Symbols for INTS7 Gene

  • C1orf73

Previous GeneCards Identifiers for INTS7 Gene

  • GC01M210180
  • GC01M212113
  • GC01M182792

Summaries for INTS7 Gene

Entrez Gene Summary for INTS7 Gene

  • This gene encodes a subunit of the integrator complex. The integrator complex associates with the C-terminal domain of RNA polymerase II and mediates 3'-end processing of the small nuclear RNAs U1 and U2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for INTS7 Gene

INTS7 (Integrator Complex Subunit 7) is a Protein Coding gene. Among its related pathways are Gene Expression and RNA Polymerase II Transcription Initiation And Promoter Clearance. GO annotations related to this gene include binding.

UniProtKB/Swiss-Prot for INTS7 Gene

  • Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Plays a role in DNA damage response (DDR) signaling during the S phase.

Gene Wiki entry for INTS7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INTS7 Gene

Genomics for INTS7 Gene

Regulatory Elements for INTS7 Gene

Promoters for INTS7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around INTS7 on UCSC Golden Path with GeneCards custom track

Genomic Location for INTS7 Gene

Chromosome:
1
Start:
211,940,399 bp from pter
End:
212,035,677 bp from pter
Size:
95,279 bases
Orientation:
Minus strand

Genomic View for INTS7 Gene

Genes around INTS7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INTS7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INTS7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INTS7 Gene

Proteins for INTS7 Gene

  • Protein details for INTS7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVH2-INT7_HUMAN
    Recommended name:
    Integrator complex subunit 7
    Protein Accession:
    Q9NVH2
    Secondary Accessions:
    • B4DLZ6
    • B7WNP6
    • B7WPB6
    • Q8N4K7
    • Q8WUH5
    • Q9H9V3
    • Q9NVU5
    • Q9UFC6
    • Q9UFM3

    Protein attributes for INTS7 Gene

    Size:
    962 amino acids
    Molecular mass:
    106834 Da
    Quaternary structure:
    • Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12. Interacts with NABP2.
    SequenceCaution:
    • Sequence=BAA91650.1; Type=Erroneous termination; Positions=618; Note=Translated as Cys.; Evidence={ECO:0000305}; Sequence=BAB14116.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for INTS7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for INTS7 Gene

Proteomics data for INTS7 Gene at MOPED

Post-translational modifications for INTS7 Gene

  • Ubiquitination at Lys 105, Lys 346, Lys 672, Lys 840, Lys 867, and Lys 929
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for INTS7 Gene

Domains & Families for INTS7 Gene

Protein Domains for INTS7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for INTS7 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NVH2

UniProtKB/Swiss-Prot:

INT7_HUMAN :
  • Belongs to the Integrator subunit 7 family.
Family:
  • Belongs to the Integrator subunit 7 family.
genes like me logo Genes that share domains with INTS7: view

No data available for Gene Families for INTS7 Gene

Function for INTS7 Gene

Molecular function for INTS7 Gene

UniProtKB/Swiss-Prot Function:
Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Plays a role in DNA damage response (DDR) signaling during the S phase.
genes like me logo Genes that share phenotypes with INTS7: view

Animal Model Products

  • Taconic Biosciences Mouse Models for INTS7

miRNA for INTS7 Gene

miRTarBase miRNAs that target INTS7

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for INTS7 Gene

Localization for INTS7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for INTS7 Gene

Nucleus. Chromosome. Note=Localizes to sites of DNA damage in a H2AX-independent manner.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for INTS7 Gene COMPARTMENTS Subcellular localization image for INTS7 gene
Compartment Confidence
nucleus 4
plasma membrane 3
cytosol 2
endoplasmic reticulum 1

No data available for Gene Ontology (GO) - Cellular Components for INTS7 Gene

Pathways & Interactions for INTS7 Gene

genes like me logo Genes that share pathways with INTS7: view

Pathways by source for INTS7 Gene

2 Reactome pathways for INTS7 Gene

Gene Ontology (GO) - Biological Process for INTS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000077 DNA damage checkpoint IMP 21659603
GO:0042795 snRNA transcription from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with INTS7: view

No data available for SIGNOR curated interactions for INTS7 Gene

Drugs & Compounds for INTS7 Gene

(3) Additional Compounds for INTS7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with INTS7: view

Transcripts for INTS7 Gene

Unigene Clusters for INTS7 Gene

Integrator complex subunit 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for INTS7 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20
SP1:
SP2: -
SP3: -

Relevant External Links for INTS7 Gene

GeneLoc Exon Structure for
INTS7
ECgene alternative splicing isoforms for
INTS7

Expression for INTS7 Gene

mRNA expression in normal human tissues for INTS7 Gene

Protein differential expression in normal tissues from HIPED for INTS7 Gene

This gene is overexpressed in CD8 Tcells (12.3), Skin (8.6), and Peripheral blood mononuclear cells (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for INTS7 Gene



SOURCE GeneReport for Unigene cluster for INTS7 Gene Hs.369285

genes like me logo Genes that share expression patterns with INTS7: view

Protein tissue co-expression partners for INTS7 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for INTS7 Gene

Orthologs for INTS7 Gene

This gene was present in the common ancestor of animals.

Orthologs for INTS7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia INTS7 35
  • 91.58 (n)
  • 98.23 (a)
INTS7 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia INTS7 35
  • 92.62 (n)
  • 98.65 (a)
INTS7 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ints7 35
  • 86.21 (n)
  • 95.11 (a)
Ints7 16
Ints7 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia INTS7 35
  • 99.62 (n)
  • 100 (a)
INTS7 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ints7 35
  • 86.61 (n)
  • 95.51 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 90 (a)
OneToMany
-- 36
  • 95 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia INTS7 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves INTS7 35
  • 80.82 (n)
  • 92.26 (a)
INTS7 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia INTS7 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ints7 35
  • 74.88 (n)
  • 85.45 (a)
Str.19657 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.15899 35
zebrafish
(Danio rerio)
Actinopterygii dkfzp434b168 35
ints7 35
  • 69.87 (n)
  • 76.82 (a)
ints7 36
  • 76 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10539 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011393 35
  • 46.5 (n)
  • 39.6 (a)
fruit fly
(Drosophila melanogaster)
Insecta defl 35
  • 46.5 (n)
  • 39.07 (a)
defl 36
  • 34 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea D1043.1 36
  • 20 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToOne
Species with no ortholog for INTS7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for INTS7 Gene

ENSEMBL:
Gene Tree for INTS7 (if available)
TreeFam:
Gene Tree for INTS7 (if available)

Paralogs for INTS7 Gene

No data available for Paralogs for INTS7 Gene

Variants for INTS7 Gene

Sequence variations from dbSNP and Humsavar for INTS7 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs17851788 - 211,978,468(+) TAAGA(C/T)GGGGC nc-transcript-variant, reference, missense
rs13418 -- 211,942,063(+) ATTAT(G/T)AGGTT nc-transcript-variant, reference, missense
rs265065 -- 211,964,783(-) atcca(C/G)tttca intron-variant
rs1052351 -- 211,940,628(-) TGGTT(A/G)AAAAC nc-transcript-variant, utr-variant-3-prime
rs1316820 -- 211,977,946(+) TAAAA(A/G)TTTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for INTS7 Gene

Variant ID Type Subtype PubMed ID
nsv4432 CNV Insertion 18451855

Variation tolerance for INTS7 Gene

Residual Variation Intolerance Score: 3.66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.47; 43.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for INTS7 Gene

HapMap Linkage Disequilibrium report
INTS7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INTS7 Gene

Disorders for INTS7 Gene

Relevant External Links for INTS7

Genetic Association Database (GAD)
INTS7
Human Genome Epidemiology (HuGE) Navigator
INTS7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
INTS7

No disorders were found for INTS7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for INTS7 Gene

Publications for INTS7 Gene

  1. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PMID: 16239144) Baillat D. … Shiekhattar R. (Cell 2005) 2 3 4 67
  2. Transcriptional regulation of an evolutionary conserved intergenic region of CDT2-INTS7. (PMID: 18213392) Nakagawa H. … Yoshida K. (PLoS ONE 2008) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. (PMID: 24778252) Li S. … Dorf M.E. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3

Products for INTS7 Gene

Sources for INTS7 Gene

Back to Top

Content