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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

INTS7 Gene

protein-coding   GIFtS: 53
GCID: GC01M212113

Integrator Complex Subunit 7

(Previous name: chromosome 1 open reading frame 73)
(Previous symbol: C1orf73)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 8

Aliases
Integrator Complex Subunit 71 2
C1orf731 2 3
Chromosome 1 Open Reading Frame 731
INT72
Int73

External Ids:    HGNC: 244841   Entrez Gene: 258962   Ensembl: ENSG000001434937   OMIM: 6113505   UniProtKB: Q9NVH23   
ORGUL members:         
NONCODE14:n410524 n326239 n326240      

Export aliases for INTS7 gene to outside databases

Previous GC identifers: GC01M210180 GC01M182792


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for INTS7 Gene:
This gene encodes a subunit of the integrator complex. The integrator complex associates with the C-terminal
domain of RNA polymerase II and mediates 3'-end processing of the small nuclear RNAs U1 and U2. Alternatively
spliced transcript variants encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Dec
2010)

GeneCards Summary for INTS7 Gene: 
INTS7 (integrator complex subunit 7) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with INTS7 include complex regional pain syndrome, and paine syndrome. GO annotations related to this gene include protein binding.

UniProtKB/Swiss-Prot: INT7_HUMAN, Q9NVH2
Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2
transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal
domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Plays
a role in DNA damage response (DDR) signaling during the S phase

Gene Wiki entry for INTS7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the INTS7 gene promoter:
         p53   Bach2   C/EBPalpha   GATA-1   GATA-2   AREB6   deltaCREB   ARP-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidINTS7 promoter sequence
   Search SABiosciences Chromatin IP Primers for INTS7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INTS7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.3   Ensembl cytogenetic band:  1q32.3   HGNC cytogenetic band: 1q32.3

INTS7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INTS7 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M212113:  view genomic region     (about GC identifiers)

Start:
212,113,741 bp from pter      End:
212,209,002 bp from pter
Size:
95,262 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for INTS7

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: INT7_HUMAN, Q9NVH2 (See protein sequence)
Recommended Name: Integrator complex subunit 7  
Size: 962 amino acids; 106834 Da
Subunit: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5,
INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12. Interacts with NABP2
Subcellular location: Nucleus. Chromosome. Note=Localizes to sites of DNA damage in a H2AX-independent manner
Sequence caution: Sequence=BAA91650.1; Type=Erroneous termination; Positions=618; Note=Translated as Cys;
Sequence=BAB14116.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B4DLZ6 B7WNP6 B7WPB6 Q8N4K7 Q8WUH5 Q9H9V3 Q9NVU5 Q9UFC6 Q9UFM3
Alternative splicing: 4 isoforms:  Q9NVH2-1   Q9NVH2-2   Q9NVH2-3   Q9NVH2-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for INTS7: NX_Q9NVH2

Explore proteomics data for INTS7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NVH2

  • INTS7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    INTS7 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001186738.1  NP_001186740.1  NP_001186741.1  NP_056249.1  

    ENSEMBL proteins: 
     ENSP00000355961   ENSP00000355960   ENSP00000355959   ENSP00000388908  

    Human Recombinant Protein Products for INTS7: 
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    OriGene Protein Over-expression Lysate for INTS7
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    Novus Biologicals INTS7 Protein
    Novus Biologicals INTS7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for INTS7 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005694chromosome IDA--
    GO:0032039integrator complex IDA16239144

    INTS7 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for INTS7 
    Cloud-Clone Corp. CLIAs for INTS7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR011989 ARM-like
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q9NVH2

    ProtoNet protein and cluster: Q9NVH2

    UniProtKB/Swiss-Prot: INT7_HUMAN, Q9NVH2
    Similarity: Belongs to the Integrator subunit 7 family


    INTS7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: INT7_HUMAN, Q9NVH2
    Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2
    transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal
    domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Plays
    a role in DNA damage response (DDR) signaling during the S phase

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI16239144
         
    INTS7 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for INTS7:
     Decreased BPV1 E2 protein expr  Decreased Tat-dependent transc  Decreased p24 protein expressi  Decreased viability of wild-ty 
     Increased HPV18 LCR reporter a  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for INTS7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for INTS7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for INTS7 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for INTS7 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat INTS7
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate INTS7 (see all 11):
    hsa-miR-323-3p hsa-miR-125a-5p hsa-miR-3139 hsa-miR-1305 hsa-miR-708 hsa-miR-125b hsa-miR-670 hsa-miR-28-5p
    SwitchGear 3'UTR luciferase reporter plasmidINTS7 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for INTS7
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    Gene Editing
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    Sino Biological Human cDNA Clone for INTS7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INTS7
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTS7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for INTS7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/19 Interacting proteins for INTS7 (Q9NVH23 ENSP000003559614) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    INTS5Q6P9B93, ENSP000003278894I2D: score=1 STRING: ENSP00000327889
    RPAP2Q8IXW53, ENSP000003593684I2D: score=1 STRING: ENSP00000359368
    INTS1Q8N2013, ENSP000003857224I2D: score=1 STRING: ENSP00000385722
    INTS3Q68E013, ENSP000003186414I2D: score=1 STRING: ENSP00000318641
    INTS6Q9UL033, ENSP000003102604I2D: score=1 STRING: ENSP00000310260
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000077DNA damage checkpoint IMP--
    GO:0016180snRNA processing IDA16239144
    GO:0071479cellular response to ionizing radiation IDA--

    INTS7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    INTS7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for INTS7 (INT7)

    3 Novoseek inferred chemical compound relationships for INTS7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphorus 35 1 19728718 (1)
    silver 19.7 2 15154812 (1), 16499392 (1)
    oxygen 0 1 16351102 (1)

    Search CenterWatch for drugs/clinical trials and news about INTS7 / INT7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for INTS7 gene (4 alternative transcripts): 
    NM_001199809.1  NM_001199811.1  NM_001199812.1  NM_015434.3  

    Unigene Cluster for INTS7:

    Integrator complex subunit 7
    Hs.369285  [show with all ESTs]
    Unigene Representative Sequence: NR_037667
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000469606(uc001hix.2) ENST00000366994(uc009xdb.2 uc001hiw.2 uc001hiy.2 uc010pta.2)
    ENST00000366993 ENST00000366992 ENST00000475798 ENST00000461212 ENST00000462910
    ENST00000460867 ENST00000440600
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat INTS7
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate INTS7 (see all 11):
    hsa-miR-323-3p hsa-miR-125a-5p hsa-miR-3139 hsa-miR-1305 hsa-miR-708 hsa-miR-125b hsa-miR-670 hsa-miR-28-5p
    SwitchGear 3'UTR luciferase reporter plasmidINTS7 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 4): INTS7 (NM_015434)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INTS7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INTS7
    Sirion Biotech Customized lentivirus for stable overexpression of INTS7 
                         Customized lentivirus expression plasmids for stable overexpression of INTS7 
    Primer
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    OriGene qPCR primer pairs and template standards for INTS7
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat INTS7
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INTS7
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INTS7

    Additional mRNA sequence: 

    AK001363.1 AK001598.1 AK022509.1 AK022589.1 AK297225.1 AL117576.1 AL133049.2 BC009918.2 
    BC020523.2 BC030716.1 BC033918.1 BC036009.1 NR_037667.1 

    16 DOTS entries:

    DT.100800179  DT.100817007  DT.100761934  DT.95166593  DT.121378493  DT.100817008  DT.305831  DT.121378435 
    DT.91847182  DT.100817006  DT.40113092  DT.75143641  DT.95087777  DT.95166591  DT.405249  DT.99931047 

    24/146 AceView cDNA sequences (see all 146):

    BC033918 AK001598 BC030716 AU127024 BG940447 AA431971 BQ225910 AK022509 
    NM_015434 BX643057 AI079443 BC036009 BP341103 AW591057 BE893815 AU132636 
    BF514719 AL117576 W17018 BM753269 AA418221 AL133049 AK022589 AU124490 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for INTS7    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20
    SP1:                                                                                                                                          
    SP2:                                                                                                              -                           
    SP3:                                                                                                                    -                     


    ECgene alternative splicing isoforms for INTS7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    INTS7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAATGAATGC
    INTS7 Expression
    About this image


    See INTS7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for INTS7

    SOURCE GeneReport for Unigene cluster: Hs.369285
        SABiosciences Custom PCR Arrays for INTS7
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INTS7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTS7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for INTS7 gene from 7/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ints71 , 5 integrator complex subunit 71, 5 86.47(n)1
    95.53(a)1
      1 (96.51 cM)5
    770651  NM_178632.51  NP_848747.41 
     1915757345 
    chicken
    (Gallus gallus)
    Aves INTS71 integrator complex subunit 7 80.82(n)
    92.26(a)
      421374  NM_001006399.1  NP_001006399.1 
    lizard
    (Anolis carolinensis)
    Reptilia INTS76
    Uncharacterized protein
    89(a)
    1 ↔ 1
    1(238280644-238332335)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.158992 Xenopus laevis transcribed sequence with moderate similarity more 75.55(n)    BJ061277.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dkfzp434b1682 DKFZP434B168 protein homolog (human) 73.78(n)   286776  AY099529.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta defl1 deflated 45.34(n)
    37.99(a)
      39141  NM_140095.3  NP_648352.2 
    worm
    (Caenorhabditis elegans)
    Secernentea D1043.16
    Protein D1043.1
    21(a)
    1 ↔ 1
    II(11582849-11588534)


    ENSEMBL Gene Tree for INTS7 (if available)
    TreeFam Gene Tree for INTS7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1945 SNPs in INTS7 are shown (see all 1945)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1384221011,2
    --212113397(+) GTTCTA/GCACTG 5 -- ds50010--------
    rs1142961681,2
    F--212113436(+) CCCAGG/TTGCTG 5 -- ds50011Minor allele frequency- T:0.04NA 120
    rs1148813101,2
    C,F--212113507(+) TCAACC/AGTGGA 5 -- ds50011Minor allele frequency- A:0.05WA 118
    rs1826412171,2
    --212113548(+) TGTTCA/TGGCTG 5 -- ds50010--------
    rs741377901,2
    C,F--212113556(+) CTGTTA/CGCAGT 5 -- ds50012Minor allele frequency- C:0.04WA 120
    rs1875645041,2
    --212113579(+) GCTCAC/TGAAGG 5 -- ds50010--------
    rs754408351,2
    C--212113666(+) ACAACA/CACCCC 5 -- ds50013Minor allele frequency- C:0.04CSA NA EA 242
    rs1418823221,2
    --212113709(+) TTGAAC/TTAATG 5 -- ds50010--------
    rs1916097201,2
    --212113723(+) ACTTTA/GAAGAG 5 -- ds50010--------
    rs730910461,2
    C--212113833(+) ACTTAC/TAGCAT 5 -- ut31 nc-transcript-variant1Minor allele frequency- T:0.50WA 2

    HapMap Linkage Disequilibrium report for INTS7 (212113741 - 212209002 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for INTS7:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv4432CNV Insertion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611350    OMIM disorders: --

    3 diseases for INTS7:    About MalaCards
    complex regional pain syndrome    paine syndrome    alcoholism


    INTS7 for disorders           About GeneDecksing

    Genetic Association Database (GAD): INTS7
    Human Genome Epidemiology (HuGE) Navigator: INTS7 (2 documents)

    Export disorders for INTS7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for INTS7 gene, integrated from 9 sources (see all 98):
    (articles sorted by number of sources associating them with INTS7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PubMed id 16239144)1, 2, 3 Baillat D....Shiekhattar R. (2005)
    2. Genome-wide association study of temperament in bipola r disorder reveals significant associations with three novel Loci. (PubMed id 22365631)1, 4 Greenwood T.A....Kelsoe J.R. (2012)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    7. Transcriptional regulation of an evolutionary conserved intergenic region of CDT2-INTS7. (PubMed id 18213392)1, 9 Nakagawa H....Yoshida K. (2008)
    8. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 25896 HGNC: 24484 AceView: DKFZP434B168 Ensembl:ENSG00000143493 euGenes: HUgn25896
    ECgene: INTS7 H-InvDB: INTS7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for INTS7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for INTS7 gene:
    Search GeneIP for patents involving INTS7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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