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INTS7 Gene

protein-coding   GIFtS: 53
GCID: GC01M212113

Integrator Complex Subunit 7

(Previous name: chromosome 1 open reading frame 73)
(Previous symbol: C1orf73)
  Search for INTS7
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Integrator Complex Subunit 71 2
C1orf731 2 3
INT72 5
Chromosome 1 Open Reading Frame 731
Int73

External Ids:    HGNC: 244841   Entrez Gene: 258962   Ensembl: ENSG000001434937   OMIM: 6113505   UniProtKB: Q9NVH23   

Export aliases for INTS7 gene to outside databases

Previous GC identifers: GC01M210180 GC01M182792


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for INTS7 Gene:
This gene encodes a subunit of the integrator complex. The integrator complex associates with the C-terminal
domain of RNA polymerase II and mediates 3'-end processing of the small nuclear RNAs U1 and U2. Alternatively
spliced transcript variants encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Dec
2010)

GeneCards Summary for INTS7 Gene:
INTS7 (integrator complex subunit 7) is a protein-coding gene.

UniProtKB/Swiss-Prot: INT7_HUMAN, Q9NVH2
Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2
transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal
domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Plays
a role in DNA damage response (DDR) signaling during the S phase

Gene Wiki entry for INTS7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the INTS7 gene promoter:
         p53   Bach2   C/EBPalpha   GATA-1   GATA-2   AREB6   deltaCREB   ARP-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidINTS7 promoter sequence
   Search Chromatin IP Primers for INTS7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat INTS7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.3   Ensembl cytogenetic band:  1q32.3   HGNC cytogenetic band: 1q32.3

INTS7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INTS7 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M212113:  view genomic region     (about GC identifiers)

Start:
212,113,741 bp from pter      End:
212,209,002 bp from pter
Size:
95,262 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for INTS7

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: INT7_HUMAN, Q9NVH2 (See protein sequence)
Recommended Name: Integrator complex subunit 7  
Size: 962 amino acids; 106834 Da
Subunit: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5,
INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12. Interacts with NABP2
Sequence caution: Sequence=BAA91650.1; Type=Erroneous termination; Positions=618; Note=Translated as Cys;
Sequence=BAB14116.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B4DLZ6 B7WNP6 B7WPB6 Q8N4K7 Q8WUH5 Q9H9V3 Q9NVU5 Q9UFC6 Q9UFM3
Alternative splicing: 4 isoforms:  Q9NVH2-1   Q9NVH2-2   Q9NVH2-3   Q9NVH2-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for INTS7: NX_Q9NVH2

Explore proteomics data for INTS7 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys105, Lys346, Lys672, Lys840, Lys867, Lys929
  • Modification sites at PhosphoSitePlus

  • See INTS7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001186738.1  NP_001186740.1  NP_001186741.1  NP_056249.1  

    ENSEMBL proteins: 
     ENSP00000355961   ENSP00000355960   ENSP00000355959   ENSP00000388908  

    INTS7 Human Recombinant Protein Products:

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    Novus Biologicals INTS7 Protein
    Novus Biologicals INTS7 Lysates
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    Cloud-Clone Corp. Proteins for INTS7

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR011989 ARM-like
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q9NVH2

    ProtoNet protein and cluster: Q9NVH2

    UniProtKB/Swiss-Prot: INT7_HUMAN, Q9NVH2
    Similarity: Belongs to the Integrator subunit 7 family


    Find genes that share domains with INTS7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: INT7_HUMAN, Q9NVH2
    Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2
    transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal
    domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Plays
    a role in DNA damage response (DDR) signaling during the S phase

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI16239144
         
    Find genes that share ontologies with INTS7           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for INTS7:
     Decreased BPV1 E2 protein expr  Decreased Tat-dependent transc  Decreased p24 protein expressi  Decreased viability of wild-ty 
     Increased HPV18 LCR reporter a  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for INTS7
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for INTS7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for INTS7

    miRNA
    Products:
        
    miRTarBase miRNAs that target INTS7:
    hsa-mir-26b-5p (MIRT029468), hsa-mir-155-5p (MIRT020750), hsa-let-7b-5p (MIRT032348)

    Block miRNA regulation of human, mouse, rat INTS7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate INTS7 (see all 11):
    hsa-miR-323-3p hsa-miR-125a-5p hsa-miR-3139 hsa-miR-1305 hsa-miR-708 hsa-miR-125b hsa-miR-670 hsa-miR-28-5p
    SwitchGear 3'UTR luciferase reporter plasmidINTS7 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for INTS7
    Predesigned siRNA for gene silencing in human, mouse, rat INTS7

    Gene Editing
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): INTS7 (NM_015434)
    Sino Biological Human cDNA Clone for INTS7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INTS7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INTS7

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTS7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    INT7_HUMAN, Q9NVH2: Nucleus. Chromosome. Note=Localizes to sites of DNA damage in a H2AX-independent manner
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane3
    cytosol2
    endoplasmic reticulum1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005694chromosome IDA--
    GO:0032039integrator complex IDA16239144

    Find genes that share ontologies with INTS7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for INTS7
    Interactions:

        Search GeneGlobe Interaction Network for INTS7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for INTS7 (Q9NVH23 ENSP000003559614) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    INTS5Q6P9B93, ENSP000003278894I2D: score=1 STRING: ENSP00000327889
    INTS1Q8N2013, ENSP000003857224I2D: score=1 STRING: ENSP00000385722
    INTS3Q68E013, ENSP000003186414I2D: score=1 STRING: ENSP00000318641
    INTS6Q9UL033, ENSP000003102604I2D: score=1 STRING: ENSP00000310260
    RPAP2Q8IXW53I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000077DNA damage checkpoint IMP--
    GO:0016180snRNA processing IDA16239144
    GO:0071479cellular response to ionizing radiation IDA--

    Find genes that share ontologies with INTS7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for INTS7 (INT7)

    3 Novoseek inferred chemical compound relationships for INTS7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphorus 35 1 19728718 (1)
    silver 19.7 2 15154812 (1), 16499392 (1)
    oxygen 0 1 16351102 (1)



    Find genes that share compounds with INTS7           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for INTS7 gene (4 alternative transcripts): 
    NM_001199809.1  NM_001199811.1  NM_001199812.1  NM_015434.3  

    Unigene Cluster for INTS7:

    Integrator complex subunit 7
    Hs.369285  [show with all ESTs]
    Unigene Representative Sequence: NR_037667
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000469606(uc001hix.2) ENST00000366994(uc009xdb.2 uc001hiw.2 uc001hiy.2 uc010pta.2)
    ENST00000366993 ENST00000366992 ENST00000475798 ENST00000461212 ENST00000462910
    ENST00000460867 ENST00000440600
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate INTS7 (see all 11):
    hsa-miR-323-3p hsa-miR-125a-5p hsa-miR-3139 hsa-miR-1305 hsa-miR-708 hsa-miR-125b hsa-miR-670 hsa-miR-28-5p
    SwitchGear 3'UTR luciferase reporter plasmidINTS7 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for INTS7
    Predesigned siRNA for gene silencing in human, mouse, rat INTS7
    Clone
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    OriGene ORF clones in mouse, rat for INTS7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): INTS7 (NM_015434)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INTS7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INTS7
    Primer
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    OriGene qPCR primer pairs and template standards for INTS7
    OriGene qSTAR qPCR primer pairs in human, mouse for INTS7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat INTS7
      QuantiTect SYBR Green Assays in human, mouse, rat INTS7
      QuantiFast Probe-based Assays in human, mouse, rat INTS7

    Additional mRNA sequence: 

    AK001363.1 AK001598.1 AK022509.1 AK022589.1 AK297225.1 AL117576.1 AL133049.2 BC009918.2 
    BC020523.2 BC030716.1 BC033918.1 BC036009.1 NR_037667.1 

    16 DOTS entries:

    DT.100800179  DT.100817007  DT.100761934  DT.95166593  DT.121378493  DT.100817008  DT.305831  DT.121378435 
    DT.91847182  DT.100817006  DT.40113092  DT.75143641  DT.95087777  DT.95166591  DT.405249  DT.99931047 

    Selected AceView cDNA sequences (see all 146):

    BC030716 AL133049 CF264686 BQ225910 AW591057 BE893815 AK001363 BX642978 
    BC033918 AK022589 AU127024 BC036009 BU507245 NM_015434 BX643057 AU124490 
    BX431731 AL117576 AU132636 AA431971 BM753269 BP341103 BG940447 BF514719 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for INTS7    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20
    SP1:                                                                                                                                          
    SP2:                                                                                                              -                           
    SP3:                                                                                                                    -                     


    ECgene alternative splicing isoforms for INTS7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    INTS7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAATGAATGC
    INTS7 Expression
    About this image

    INTS7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    INTS7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.369285
        Custom PCR Arrays for INTS7
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTS7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for INTS7 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ints71 , 5 integrator complex subunit 71, 5 86.21(n)1
    95.11(a)1
      1 (96.51 cM)5
    770651  NM_178632.51  NP_848747.41 
     1915757345 
    chicken
    (Gallus gallus)
    Aves INTS71 integrator complex subunit 7 80.82(n)
    92.26(a)
      421374  NM_001006399.1  NP_001006399.1 
    lizard
    (Anolis carolinensis)
    Reptilia INTS76
    integrator complex subunit 7
    90(a)
    1 ↔ 1
    1(238280644-238332335)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.158992 Xenopus laevis transcribed sequence with moderate similarity more 75.55(n)    BJ061277.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dkfzp434b1682 DKFZP434B168 protein homolog (human) 73.78(n)   286776  AY099529.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta defl1 deflated 46.5(n)
    39.07(a)
      39141  NM_140095.4  NP_648352.2 
    worm
    (Caenorhabditis elegans)
    Secernentea D1043.16
    Protein D1043.1 (D1043.1) mRNA, complete cds
    20(a)
    1 ↔ 1
    II(11582849-11588534) WBGene00008361


    ENSEMBL Gene Tree for INTS7 (if available)
    TreeFam Gene Tree for INTS7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for INTS7 (see all 1945)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1384221011,2
    --212113397(+) GTTCTA/GCACTG 5 -- ds50010--------
    rs1142961681,2
    F--212113436(+) CCCAGG/TTGCTG 5 -- ds50011Minor allele frequency- T:0.04NA 120
    rs1148813101,2
    C,F--212113507(+) TCAACC/AGTGGA 5 -- ds50011Minor allele frequency- A:0.05WA 118
    rs1826412171,2
    --212113548(+) TGTTCA/TGGCTG 5 -- ds50010--------
    rs741377901,2
    C,F--212113556(+) CTGTTA/CGCAGT 5 -- ds50012Minor allele frequency- C:0.04WA 120
    rs1875645041,2
    --212113579(+) GCTCAC/TGAAGG 5 -- ds50010--------
    rs754408351,2
    C--212113666(+) ACAACA/CACCCC 5 -- ds50013Minor allele frequency- C:0.04CSA NA EA 242
    rs1418823221,2
    --212113709(+) TTGAAC/TTAATG 5 -- ds50010--------
    rs1916097201,2
    --212113723(+) ACTTTA/GAAGAG 5 -- ds50010--------
    rs730910461,2
    C--212113833(+) ACTTAC/TAGCAT 5 -- ut31 nc-transcript-variant1Minor allele frequency- T:0.50WA 2

    HapMap Linkage Disequilibrium report for INTS7 (212113741 - 212209002 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for INTS7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv4432CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing INTS7
    DNA2.0 Custom Variant and Variant Library Synthesis for INTS7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611350    OMIM disorders: --


    Find genes that share disorders with INTS7           About GenesLikeMe

    Genetic Association Database (GAD): INTS7
    Human Genome Epidemiology (HuGE) Navigator: INTS7 (2 documents)

    Export disorders for INTS7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for INTS7 gene, integrated from 10 sources (see all 100):
    (articles sorted by number of sources associating them with INTS7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PubMed id 16239144)1, 2, 3 Baillat D....Shiekhattar R. (Cell 2005)
    2. Genome-wide association study of temperament in bipolar disorder reveals significant associations with three novel Loci. (PubMed id 22365631)1, 4 Greenwood T.A....Kelsoe J.R. (Biol. Psychiatry 2012)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    7. Transcriptional regulation of an evolutionary conserved intergenic region of CDT2-INTS7. (PubMed id 18213392)1, 9 Nakagawa H....Yoshida K. (PLoS ONE 2008)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25896 HGNC: 24484 AceView: DKFZP434B168 Ensembl:ENSG00000143493 euGenes: HUgn25896
    ECgene: INTS7 H-InvDB: INTS7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for INTS7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for INTS7 gene:
    Search GeneIP for patents involving INTS7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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