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Aliases for INTS7 Gene

Aliases for INTS7 Gene

  • Integrator Complex Subunit 7 2 3
  • INT7 3 4 6
  • C1orf73 3 4
  • Chromosome 1 Open Reading Frame 73 2

External Ids for INTS7 Gene

Previous HGNC Symbols for INTS7 Gene

  • C1orf73

Previous GeneCards Identifiers for INTS7 Gene

  • GC01M210180
  • GC01M212113
  • GC01M182792

Summaries for INTS7 Gene

Entrez Gene Summary for INTS7 Gene

  • This gene encodes a subunit of the integrator complex. The integrator complex associates with the C-terminal domain of RNA polymerase II and mediates 3'-end processing of the small nuclear RNAs U1 and U2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for INTS7 Gene

INTS7 (Integrator Complex Subunit 7) is a Protein Coding gene.

UniProtKB/Swiss-Prot for INTS7 Gene

  • Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Plays a role in DNA damage response (DDR) signaling during the S phase.

Gene Wiki entry for INTS7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INTS7 Gene

Genomics for INTS7 Gene

Regulatory Elements for INTS7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for INTS7 Gene

Start:
211,940,399 bp from pter
End:
212,035,660 bp from pter
Size:
95,262 bases
Orientation:
Minus strand

Genomic View for INTS7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for INTS7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INTS7 Gene

Proteins for INTS7 Gene

  • Protein details for INTS7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVH2-INT7_HUMAN
    Recommended name:
    Integrator complex subunit 7
    Protein Accession:
    Q9NVH2
    Secondary Accessions:
    • B4DLZ6
    • B7WNP6
    • B7WPB6
    • Q8N4K7
    • Q8WUH5
    • Q9H9V3
    • Q9NVU5
    • Q9UFC6
    • Q9UFM3

    Protein attributes for INTS7 Gene

    Size:
    962 amino acids
    Molecular mass:
    106834 Da
    Quaternary structure:
    • Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12. Interacts with NABP2.
    SequenceCaution:
    • Sequence=BAA91650.1; Type=Erroneous termination; Positions=618; Note=Translated as Cys.; Evidence={ECO:0000305}; Sequence=BAB14116.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for INTS7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for INTS7 Gene

Proteomics data for INTS7 Gene at MOPED

Post-translational modifications for INTS7 Gene

  • Ubiquitination at Lys105, Lys346, Lys672, Lys840, Lys867, and Lys929
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for INTS7 Gene

Domains for INTS7 Gene

Protein Domains for INTS7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for INTS7 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NVH2

UniProtKB/Swiss-Prot:

INT7_HUMAN :
  • Q9NVH2
Family:
  • Belongs to the Integrator subunit 7 family.
genes like me logo Genes that share domains with INTS7: view

No data available for Gene Families for INTS7 Gene

Function for INTS7 Gene

Molecular function for INTS7 Gene

UniProtKB/Swiss-Prot Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Plays a role in DNA damage response (DDR) signaling during the S phase.

Gene Ontology (GO) - Molecular Function for INTS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 16239144
genes like me logo Genes that share ontologies with INTS7: view
genes like me logo Genes that share phenotypes with INTS7: view

Animal Model Products

CRISPR Products

miRNA for INTS7 Gene

miRTarBase miRNAs that target INTS7

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for INTS7 Gene

Localization for INTS7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for INTS7 Gene

Nucleus. Chromosome. Note=Localizes to sites of DNA damage in a H2AX-independent manner.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for INTS7 Gene COMPARTMENTS Subcellular localization image for INTS7 gene
Compartment Confidence
nucleus 5
plasma membrane 3
cytosol 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for INTS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005694 chromosome IDA 21659603
GO:0032039 integrator complex IDA 16239144
genes like me logo Genes that share ontologies with INTS7: view

Pathways for INTS7 Gene

SuperPathways for INTS7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for INTS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000077 DNA damage checkpoint IMP 21659603
GO:0016180 snRNA processing IDA 16239144
GO:0071479 cellular response to ionizing radiation IDA 21659603
genes like me logo Genes that share ontologies with INTS7: view

No data available for Pathways by source for INTS7 Gene

Compounds for INTS7 Gene

(3) Novoseek inferred chemical compound relationships for INTS7 Gene

Compound -log(P) Hits PubMed IDs
phosphorus 35 1
silver 19.7 2
oxygen 0 1
genes like me logo Genes that share compounds with INTS7: view

Transcripts for INTS7 Gene

Unigene Clusters for INTS7 Gene

Integrator complex subunit 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for INTS7

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for INTS7 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20
SP1:
SP2: -
SP3: -

Relevant External Links for INTS7 Gene

GeneLoc Exon Structure for
INTS7
ECgene alternative splicing isoforms for
INTS7

Expression for INTS7 Gene

mRNA expression in normal human tissues for INTS7 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for INTS7 Gene

SOURCE GeneReport for Unigene cluster for INTS7 Gene Hs.369285

genes like me logo Genes that share expressions with INTS7: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for INTS7 Gene

Orthologs for INTS7 Gene

This gene was present in the common ancestor of animals.

Orthologs for INTS7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INTS7 35
  • 99.62 (n)
  • 100 (a)
INTS7 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia INTS7 35
  • 91.58 (n)
  • 98.23 (a)
INTS7 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia INTS7 35
  • 92.62 (n)
  • 98.65 (a)
INTS7 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ints7 35
  • 86.21 (n)
  • 95.11 (a)
Ints7 16
Ints7 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 90 (a)
OneToMany
-- 36
  • 95 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia INTS7 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ints7 35
  • 86.61 (n)
  • 95.51 (a)
chicken
(Gallus gallus)
Aves INTS7 35
  • 80.82 (n)
  • 92.26 (a)
INTS7 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia INTS7 36
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15899 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ints7 35
  • 74.88 (n)
  • 85.45 (a)
Str.19657 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10539 35
zebrafish
(Danio rerio)
Actinopterygii dkfzp434b168 35
ints7 35
  • 69.87 (n)
  • 76.82 (a)
ints7 36
  • 76 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011393 35
  • 46.5 (n)
  • 39.6 (a)
fruit fly
(Drosophila melanogaster)
Insecta defl 35
  • 46.5 (n)
  • 39.07 (a)
defl 36
  • 34 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea D1043.1 36
  • 20 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToOne
Species with no ortholog for INTS7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for INTS7 Gene

ENSEMBL:
Gene Tree for INTS7 (if available)
TreeFam:
Gene Tree for INTS7 (if available)

Paralogs for INTS7 Gene

No data available for Paralogs for INTS7 Gene

Variants for INTS7 Gene

Sequence variations from dbSNP and Humsavar for INTS7 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs13418 -- 211,942,063(+) ATTAT(G/T)AGGTT missense, reference, nc-transcript-variant
rs265065 -- 211,964,783(-) atcca(C/G)tttca intron-variant
rs1052351 -- 211,940,628(-) TGGTT(A/G)AAAAC utr-variant-3-prime, nc-transcript-variant
rs1316820 -- 211,977,946(+) TAAAA(A/G)TTTCA intron-variant
rs1317090 -- 212,029,573(+) CCTTA(G/T)TAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for INTS7 Gene

Variant ID Type Subtype PubMed ID
nsv4432 CNV Insertion 18451855

Relevant External Links for INTS7 Gene

HapMap Linkage Disequilibrium report
INTS7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INTS7 Gene

Disorders for INTS7 Gene

Relevant External Links for INTS7

Genetic Association Database (GAD)
INTS7
Human Genome Epidemiology (HuGE) Navigator
INTS7
genes like me logo Genes that share disorders with INTS7: view

No data available for UniProtKB/Swiss-Prot for INTS7 Gene

Publications for INTS7 Gene

  1. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PMID: 16239144) Baillat D. … Shiekhattar R. (Cell 2005) 2 3 4
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Genome-wide association study of temperament in bipolar disorder reveals significant associations with three novel Loci. (PMID: 22365631) Greenwood T.A. … Kelsoe J.R. (Biol. Psychiatry 2012) 3 48

Products for INTS7 Gene

Sources for INTS7 Gene

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