Aliases for INTS7 Gene
External Ids for INTS7 Gene
Previous HGNC Symbols for INTS7 Gene
Previous GeneCards Identifiers for INTS7 Gene
This gene encodes a subunit of the integrator complex. The integrator complex associates with the C-terminal domain of RNA polymerase II and mediates 3'-end processing of the small nuclear RNAs U1 and U2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
GeneCards Summary for INTS7 Gene
INTS7 (Integrator Complex Subunit 7) is a Protein Coding gene. Among its related pathways are Gene Expression and Formation of HIV elongation complex in the absence of HIV Tat. GO annotations related to this gene include binding.
UniProtKB/Swiss-Prot for INTS7 Gene
Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Plays a role in DNA damage response (DDR) signaling during the S phase.