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Aliases for INTS7 Gene

Aliases for INTS7 Gene

  • Integrator Complex Subunit 7 2 3 5
  • C1orf73 3 4
  • INT7 3 4
  • Chromosome 1 Open Reading Frame 73 2

External Ids for INTS7 Gene

Previous HGNC Symbols for INTS7 Gene

  • C1orf73

Previous GeneCards Identifiers for INTS7 Gene

  • GC01M210180
  • GC01M212113
  • GC01M182792

Summaries for INTS7 Gene

Entrez Gene Summary for INTS7 Gene

  • This gene encodes a subunit of the integrator complex. The integrator complex associates with the C-terminal domain of RNA polymerase II and mediates 3'-end processing of the small nuclear RNAs U1 and U2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for INTS7 Gene

INTS7 (Integrator Complex Subunit 7) is a Protein Coding gene. Among its related pathways are Gene Expression and RNA polymerase II transcribes snRNA genes. GO annotations related to this gene include binding.

UniProtKB/Swiss-Prot for INTS7 Gene

  • Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Plays a role in DNA damage response (DDR) signaling during the S phase.

Gene Wiki entry for INTS7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INTS7 Gene

Genomics for INTS7 Gene

Regulatory Elements for INTS7 Gene

Enhancers for INTS7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G212087 1.5 FANTOM5 Ensembl ENCODE 19.4 -52.9 -52893 1.3 FOXA2 PKNOX1 ARNT FEZF1 ZNF2 YY1 TCF12 ZNF766 GATA2 TSHZ1 INTS7 DTL LOC102723727 PPP2R5A GC01P212093 MIR3122
GH01G212306 0.8 dbSUPER 21 -271.8 -271844 1.5 ZFP64 TCF12 ZNF138 EGR1 ZNF354C IKZF2 ZNF202 ZNF680 ZNF362 ZNF426 INTS7 TMEM206 DTL RPL21P28 RPL23AP18 ENSG00000230063
GH01G211927 1.6 Ensembl ENCODE dbSUPER 10 +106.2 106220 3.7 HDGF FOXA2 ARNT ARID4B FEZF1 DMAP1 YY1 ZNF766 FOS SP5 LOC102723727 LPGAT1 LOC91548 NEK2 ENSG00000212187 INTS7 ENSG00000233626 PIR53279
GH01G212315 1.3 Ensembl ENCODE dbSUPER 11.2 -280.4 -280435 0.7 NFRKB RAD21 YY1 SMARCA5 ZNF654 ZNF362 USF2 REST HDAC8 TBX21 DTL INTS7 ENSG00000212187 RPL23AP18 ENSG00000234915
GH01G212430 1.4 ENCODE dbSUPER 10 -396.5 -396496 4.2 ARNT CREB3L1 SIN3A YBX1 FEZF1 ZNF2 ZNF766 ZNF143 ZNF207 KLF13 LOC101929541 TMEM206 PPP2R5A FLVCR1 INTS7 DTL ENSG00000212187 BATF3 LOC105372906
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around INTS7 on UCSC Golden Path with GeneCards custom track

Promoters for INTS7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000019650 -23 3401 CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 MEF2D GLIS1

Genomic Location for INTS7 Gene

Chromosome:
1
Start:
211,940,399 bp from pter
End:
212,035,677 bp from pter
Size:
95,279 bases
Orientation:
Minus strand

Genomic View for INTS7 Gene

Genes around INTS7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INTS7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INTS7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INTS7 Gene

Proteins for INTS7 Gene

  • Protein details for INTS7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVH2-INT7_HUMAN
    Recommended name:
    Integrator complex subunit 7
    Protein Accession:
    Q9NVH2
    Secondary Accessions:
    • B4DLZ6
    • B7WNP6
    • B7WPB6
    • Q8N4K7
    • Q8WUH5
    • Q9H9V3
    • Q9NVU5
    • Q9UFC6
    • Q9UFM3

    Protein attributes for INTS7 Gene

    Size:
    962 amino acids
    Molecular mass:
    106834 Da
    Quaternary structure:
    • Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12. Interacts with NABP2.
    SequenceCaution:
    • Sequence=BAA91650.1; Type=Erroneous termination; Positions=618; Note=Translated as Cys.; Evidence={ECO:0000305}; Sequence=BAB14116.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for INTS7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for INTS7 Gene

Post-translational modifications for INTS7 Gene

  • Ubiquitination at posLast=105105, posLast=346346, isoforms=2, 3, 4672, isoforms=2, 3, 4840, posLast=867867, and isoforms=2, 3, 4929
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for INTS7 Gene

Domains & Families for INTS7 Gene

Gene Families for INTS7 Gene

Protein Domains for INTS7 Gene

Suggested Antigen Peptide Sequences for INTS7 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NVH2

UniProtKB/Swiss-Prot:

INT7_HUMAN :
  • Belongs to the Integrator subunit 7 family.
Family:
  • Belongs to the Integrator subunit 7 family.
genes like me logo Genes that share domains with INTS7: view

Function for INTS7 Gene

Molecular function for INTS7 Gene

UniProtKB/Swiss-Prot Function:
Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Plays a role in DNA damage response (DDR) signaling during the S phase.

Gene Ontology (GO) - Molecular Function for INTS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16239144
genes like me logo Genes that share ontologies with INTS7: view
genes like me logo Genes that share phenotypes with INTS7: view

Animal Model Products

CRISPR Products

miRNA for INTS7 Gene

miRTarBase miRNAs that target INTS7

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for INTS7 Gene

Localization for INTS7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for INTS7 Gene

Nucleus. Chromosome. Note=Localizes to sites of DNA damage in a H2AX-independent manner.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for INTS7 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for INTS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 23904267
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome IDA,IEA 21659603
GO:0005737 cytoplasm IDA 23904267
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with INTS7: view

Pathways & Interactions for INTS7 Gene

genes like me logo Genes that share pathways with INTS7: view

Pathways by source for INTS7 Gene

2 Reactome pathways for INTS7 Gene

Gene Ontology (GO) - Biological Process for INTS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000077 DNA damage checkpoint IMP 21659603
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0016180 snRNA processing IDA,IEA 16239144
GO:0034472 snRNA 3-end processing IBA --
GO:0042795 snRNA transcription from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with INTS7: view

No data available for SIGNOR curated interactions for INTS7 Gene

Drugs & Compounds for INTS7 Gene

(1) Drugs for INTS7 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for INTS7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with INTS7: view

Transcripts for INTS7 Gene

Unigene Clusters for INTS7 Gene

Integrator complex subunit 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for INTS7 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20
SP1:
SP2: -
SP3: -

Relevant External Links for INTS7 Gene

GeneLoc Exon Structure for
INTS7
ECgene alternative splicing isoforms for
INTS7

Expression for INTS7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for INTS7 Gene

Protein differential expression in normal tissues from HIPED for INTS7 Gene

This gene is overexpressed in CD8 Tcells (12.3), Skin (8.6), and Peripheral blood mononuclear cells (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for INTS7 Gene



Protein tissue co-expression partners for INTS7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of INTS7 Gene:

INTS7

SOURCE GeneReport for Unigene cluster for INTS7 Gene:

Hs.369285

Evidence on tissue expression from TISSUES for INTS7 Gene

  • Nervous system(4.8)
  • Skin(4.1)
genes like me logo Genes that share expression patterns with INTS7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for INTS7 Gene

Orthologs for INTS7 Gene

This gene was present in the common ancestor of animals.

Orthologs for INTS7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INTS7 34 35
  • 99.62 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 95 (a)
OneToMany
-- 35
  • 90 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia INTS7 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia INTS7 34 35
  • 92.62 (n)
cow
(Bos Taurus)
Mammalia INTS7 34 35
  • 91.58 (n)
rat
(Rattus norvegicus)
Mammalia Ints7 34
  • 86.61 (n)
mouse
(Mus musculus)
Mammalia Ints7 34 16 35
  • 86.21 (n)
chicken
(Gallus gallus)
Aves INTS7 34 35
  • 80.82 (n)
lizard
(Anolis carolinensis)
Reptilia INTS7 35
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ints7 34
  • 74.88 (n)
Str.19657 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.15899 34
zebrafish
(Danio rerio)
Actinopterygii ints7 34 35
  • 69.87 (n)
dkfzp434b168 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10539 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011393 34
  • 46.5 (n)
fruit fly
(Drosophila melanogaster)
Insecta defl 34 35
  • 46.5 (n)
worm
(Caenorhabditis elegans)
Secernentea D1043.1 35
  • 20 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 42 (a)
OneToOne
Species where no ortholog for INTS7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for INTS7 Gene

ENSEMBL:
Gene Tree for INTS7 (if available)
TreeFam:
Gene Tree for INTS7 (if available)

Paralogs for INTS7 Gene

No data available for Paralogs for INTS7 Gene

Variants for INTS7 Gene

Sequence variations from dbSNP and Humsavar for INTS7 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000006311 -- 212,000,988(+) TCCTC(C/T)GAGGA intron-variant
rs1000037510 -- 211,953,614(+) TCTCA(C/T)TGTTC intron-variant
rs1000051419 -- 211,973,600(+) AAGAT(-/A)AGAAA intron-variant
rs1000103265 -- 211,973,398(+) TCTAT(A/C)ATTAA intron-variant
rs1000125309 -- 212,025,020(+) TATTC(A/C)CTCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for INTS7 Gene

Variant ID Type Subtype PubMed ID
esv3588741 CNV gain 21293372
nsv4432 CNV insertion 18451855

Variation tolerance for INTS7 Gene

Residual Variation Intolerance Score: 3.66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.47; 43.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for INTS7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
INTS7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INTS7 Gene

Disorders for INTS7 Gene

Relevant External Links for INTS7

Genetic Association Database (GAD)
INTS7
Human Genome Epidemiology (HuGE) Navigator
INTS7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
INTS7

No disorders were found for INTS7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for INTS7 Gene

Publications for INTS7 Gene

  1. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PMID: 16239144) Baillat D. … Shiekhattar R. (Cell 2005) 2 3 4 64
  2. Genome-wide association study of temperament in bipolar disorder reveals significant associations with three novel Loci. (PMID: 22365631) Greenwood T.A. … Kelsoe J.R. (Biol. Psychiatry 2012) 3 46 64
  3. A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling. (PMID: 21659603) Cotta-Ramusino C. … Elledge S.J. (Science 2011) 3 4 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Transcriptional regulation of an evolutionary conserved intergenic region of CDT2-INTS7. (PMID: 18213392) Nakagawa H. … Yoshida K. (PLoS ONE 2008) 3 22 64

Products for INTS7 Gene

Sources for INTS7 Gene

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