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Aliases for INTS6L Gene

Aliases for INTS6L Gene

  • Integrator Complex Subunit 6 Like 2 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 26B 2 3
  • Protein DDX26B 3 4
  • DDX26B 3 4
  • Integrator Complex Subunit 6-Like 3

External Ids for INTS6L Gene

Previous HGNC Symbols for INTS6L Gene

  • DDX26B

Summaries for INTS6L Gene

GeneCards Summary for INTS6L Gene

INTS6L (Integrator Complex Subunit 6 Like) is a Protein Coding gene. An important paralog of this gene is INTS6.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INTS6L Gene

Genomics for INTS6L Gene

Regulatory Elements for INTS6L Gene

Enhancers for INTS6L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around INTS6L on UCSC Golden Path with GeneCards custom track

Promoters for INTS6L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for INTS6L Gene

135,520,630 bp from pter
135,582,535 bp from pter
61,906 bases
Plus strand

Genomic View for INTS6L Gene

Genes around INTS6L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INTS6L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INTS6L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INTS6L Gene

Proteins for INTS6L Gene

  • Protein details for INTS6L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Integrator complex subunit 6-like
    Protein Accession:
    Secondary Accessions:
    • Q5CZA2
    • Q6IPS3
    • Q6ZTU5
    • Q6ZWE4

    Protein attributes for INTS6L Gene

    861 amino acids
    Molecular mass:
    96673 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for INTS6L Gene


neXtProt entry for INTS6L Gene

Post-translational modifications for INTS6L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for INTS6L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for INTS6L Gene

Domains & Families for INTS6L Gene

Protein Domains for INTS6L Gene


Graphical View of Domain Structure for InterPro Entry



  • Contains 1 VWFA domain.
  • Contains 1 VWFA domain.
genes like me logo Genes that share domains with INTS6L: view

No data available for Gene Families for INTS6L Gene

Function for INTS6L Gene

genes like me logo Genes that share phenotypes with INTS6L: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for INTS6L Gene

Localization for INTS6L Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for INTS6L Gene

Pathways & Interactions for INTS6L Gene

SuperPathways for INTS6L Gene

No Data Available

Interacting Proteins for INTS6L Gene

Selected Interacting proteins: Q5JSJ4-INT6L_HUMAN for INTS6L Gene via IID

Gene Ontology (GO) - Biological Process for INTS6L Gene


No data available for Pathways by source and SIGNOR curated interactions for INTS6L Gene

Drugs & Compounds for INTS6L Gene

No Compound Related Data Available

Transcripts for INTS6L Gene

Unigene Clusters for INTS6L Gene

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for INTS6L Gene

No ASD Table

Relevant External Links for INTS6L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for INTS6L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of INTS6L Gene:


SOURCE GeneReport for Unigene cluster for INTS6L Gene:

genes like me logo Genes that share expression patterns with INTS6L: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for INTS6L Gene

Orthologs for INTS6L Gene

This gene was present in the common ancestor of animals.

Orthologs for INTS6L Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC540312 34
  • 93.54 (n)
  • 93.34 (a)
DDX26B 35
  • 89 (a)
(Mus musculus)
Mammalia Ints6l 16
Ddx26b 35
  • 90 (a)
Ddx26b 34
  • 90.4 (n)
  • 90.36 (a)
(Canis familiaris)
Mammalia DDX26B 35
  • 93 (a)
DDX26B 34
  • 93.34 (n)
  • 93.73 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 77 (a)
(Pan troglodytes)
Mammalia DDX26B 35
  • 100 (a)
DDX26B 34
  • 99.69 (n)
  • 99.54 (a)
(Rattus norvegicus)
Mammalia Ddx26b 34
  • 87.04 (n)
  • 84.79 (a)
(Gallus gallus)
Aves DDX26B 34
  • 78.53 (n)
  • 80.23 (a)
-- 35
  • 69 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5728 34
ddx26b 34
  • 72.1 (n)
  • 76.79 (a)
(Danio rerio)
Actinopterygii ddx26b 34
  • 65.84 (n)
  • 71.87 (a)
ddx26b 35
  • 67 (a)
fruit fly
(Drosophila melanogaster)
Insecta IntS6 34
  • 54.23 (n)
  • 52.73 (a)
IntS6 35
  • 25 (a)
(Caenorhabditis elegans)
Secernentea dic-1 35
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 41 (a)
Species where no ortholog for INTS6L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for INTS6L Gene

Gene Tree for INTS6L (if available)
Gene Tree for INTS6L (if available)

Paralogs for INTS6L Gene

genes like me logo Genes that share paralogs with INTS6L: view

Variants for INTS6L Gene

Sequence variations from dbSNP and Humsavar for INTS6L Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_069425 -
rs967139 -- 135,563,633(+) TGTGT(A/G)TATAT intron-variant
rs975962 -- 135,549,224(-) TCTGA(C/T)AAAAA intron-variant
rs1397384 -- 135,548,039(-) TTACA(A/C)ATTTA intron-variant
rs1510594 -- 135,549,218(-) AAAAA(C/T)AGATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for INTS6L Gene

Variant ID Type Subtype PubMed ID
dgv531n21 CNV gain 19592680
esv2758895 CNV gain+loss 17122850
nsv522205 CNV gain 19592680

Variation tolerance for INTS6L Gene

Residual Variation Intolerance Score: 19.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.49; 43.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for INTS6L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INTS6L Gene

Disorders for INTS6L Gene

Relevant External Links for INTS6L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for INTS6L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for INTS6L Gene

Publications for INTS6L Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 65
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 65
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 65
  5. Diagnostic exome sequencing in persons with severe intellectual disability. (PMID: 23033978) de Ligt J. … Vissers L.E. (N. Engl. J. Med. 2012) 4 65

Products for INTS6L Gene

Sources for INTS6L Gene

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