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Aliases for INTS6L Gene

Aliases for INTS6L Gene

  • Integrator Complex Subunit 6 Like 2 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 26B 2 3
  • Protein DDX26B 3 4
  • DDX26B 3 4
  • Integrator Complex Subunit 6-Like 3

External Ids for INTS6L Gene

Previous HGNC Symbols for INTS6L Gene

  • DDX26B

Summaries for INTS6L Gene

GeneCards Summary for INTS6L Gene

INTS6L (Integrator Complex Subunit 6 Like) is a Protein Coding gene. An important paralog of this gene is INTS6.

Additional gene information for INTS6L Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INTS6L Gene

Genomics for INTS6L Gene

Regulatory Elements for INTS6L Gene

Enhancers for INTS6L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH134913 1.3 FANTOM5 ENCODE 19.5 -605.8 -605760 2 PKNOX1 ARID4B SIN3A GLI4 ZNF2 ZNF121 ZNF766 ZNF143 ATF7 SP3 ZNF75D INTS6L FAM122B PHF6 RTL8B MOSPD1 GC0XP134864
GH0XH134795 1 ENCODE 9.9 -723.8 -723833 2 ATF1 ARID4B SIN3A DMAP1 GLI4 GLIS2 SP3 NFYC REST KAT8 FAM122B RPL36AP54 INTS6L FAM122C
GH0XH135519 1.1 ENCODE 6.6 +1.4 1377 5 PKNOX1 ARNT SIN3A YY1 ZNF766 ZNF143 SP3 REST SMARCB1 ZNF592 ZNF75D INTS6L INTS6L-AS1 PIR34853
GH0XH134684 0.7 ENCODE dbSUPER 10.3 -835.2 -835241 2 JUND POLR2A ZNF140 ZNF75D FAM122B INTS6L PHF6 GC0XP134651 RNU4-44P GC0XM134761
GH0XH135527 0.5 ENCODE 5.3 +7.6 7552 0 E2F5 IKZF1 HMBOX1 INTS6L INTS6L-AS1 PIR34853
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around INTS6L on UCSC Golden Path with GeneCards custom track

Promoters for INTS6L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000249015 870 3001 PKNOX1 ARNT SIN3A YY1 ZNF766 ZNF143 SP3 REST SMARCB1 ZNF592

Genomic Location for INTS6L Gene

135,520,630 bp from pter
135,582,535 bp from pter
61,906 bases
Plus strand

Genomic View for INTS6L Gene

Genes around INTS6L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INTS6L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INTS6L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INTS6L Gene

Proteins for INTS6L Gene

  • Protein details for INTS6L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Integrator complex subunit 6-like
    Protein Accession:
    Secondary Accessions:
    • Q5CZA2
    • Q6IPS3
    • Q6ZTU5
    • Q6ZWE4

    Protein attributes for INTS6L Gene

    861 amino acids
    Molecular mass:
    96673 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for INTS6L Gene


neXtProt entry for INTS6L Gene

Post-translational modifications for INTS6L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for INTS6L Gene

Domains & Families for INTS6L Gene

Gene Families for INTS6L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for INTS6L Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with INTS6L: view

No data available for UniProtKB/Swiss-Prot for INTS6L Gene

Function for INTS6L Gene

genes like me logo Genes that share phenotypes with INTS6L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for INTS6L
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for INTS6L Gene

Localization for INTS6L Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for INTS6L gene
Compartment Confidence
nucleus 3
cytoskeleton 2
mitochondrion 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Mitochondria (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for INTS6L Gene

Pathways & Interactions for INTS6L Gene

SuperPathways for INTS6L Gene

No Data Available

Gene Ontology (GO) - Biological Process for INTS6L Gene


No data available for Pathways by source and SIGNOR curated interactions for INTS6L Gene

Drugs & Compounds for INTS6L Gene

No Compound Related Data Available

Transcripts for INTS6L Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for INTS6L
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for INTS6L Gene

No ASD Table

Relevant External Links for INTS6L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for INTS6L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of INTS6L Gene:

genes like me logo Genes that share expression patterns with INTS6L: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for INTS6L Gene

Orthologs for INTS6L Gene

This gene was present in the common ancestor of animals.

Orthologs for INTS6L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DDX26B 34 33
  • 99.69 (n)
(Bos Taurus)
Mammalia LOC540312 33
  • 93.54 (n)
DDX26B 34
  • 89 (a)
(Canis familiaris)
Mammalia DDX26B 34 33
  • 93.34 (n)
(Mus musculus)
Mammalia Ddx26b 34 33
  • 90.4 (n)
Ints6l 16
(Rattus norvegicus)
Mammalia Ddx26b 33
  • 87.04 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 77 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 59 (a)
(Gallus gallus)
Aves DDX26B 33
  • 78.53 (n)
-- 34
  • 69 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx26b 33
  • 72.1 (n)
Str.5728 33
(Danio rerio)
Actinopterygii ddx26b 33 34
  • 65.84 (n)
fruit fly
(Drosophila melanogaster)
Insecta IntS6 33 34
  • 54.23 (n)
(Caenorhabditis elegans)
Secernentea dic-1 34
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 41 (a)
Species where no ortholog for INTS6L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for INTS6L Gene

Gene Tree for INTS6L (if available)
Gene Tree for INTS6L (if available)

Paralogs for INTS6L Gene

genes like me logo Genes that share paralogs with INTS6L: view

Variants for INTS6L Gene

Sequence variations from dbSNP and Humsavar for INTS6L Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs782242788 Uncertain significance 135,546,392(+) ATCCA(-/T)TTTTT nc-transcript-variant, reference, utr-variant-3-prime, frameshift-variant, utr-variant-5-prime
rs1000263349 -- 135,567,934(+) TTCAG(A/G)TTTTC intron-variant, utr-variant-3-prime
rs1000447403 -- 135,580,572(+) CCCAT(A/G)GCCCC intron-variant
rs1000507609 -- 135,528,664(+) ATTAA(C/G)TAAAT intron-variant
rs1000538752 -- 135,528,221(+) ATTAT(C/T)TCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for INTS6L Gene

Variant ID Type Subtype PubMed ID
dgv531n21 CNV gain 19592680
esv2758895 CNV gain+loss 17122850
nsv522205 CNV gain 19592680

Variation tolerance for INTS6L Gene

Residual Variation Intolerance Score: 19.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.49; 43.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for INTS6L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INTS6L Gene

Disorders for INTS6L Gene

Relevant External Links for INTS6L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for INTS6L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for INTS6L Gene

Publications for INTS6L Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 60
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 60
  5. Diagnostic exome sequencing in persons with severe intellectual disability. (PMID: 23033978) de Ligt J … Vissers LE (The New England journal of medicine 2012) 4 60

Products for INTS6L Gene

Sources for INTS6L Gene

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