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Aliases for INTS6L Gene

Aliases for INTS6L Gene

  • Integrator Complex Subunit 6 Like 2 3
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 26B 2 3 5
  • DDX26B 3 4 5

External Ids for INTS6L Gene

Previous HGNC Symbols for INTS6L Gene

  • DDX26B

Summaries for INTS6L Gene

GeneCards Summary for INTS6L Gene

INTS6L (Integrator Complex Subunit 6 Like) is a Protein Coding gene. An important paralog of this gene is CT45A6.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INTS6L Gene

Genomics for INTS6L Gene

Regulatory Elements for INTS6L Gene

Enhancers for INTS6L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around INTS6L on UCSC Golden Path with GeneCards custom track

Promoters for INTS6L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around INTS6L on UCSC Golden Path with GeneCards custom track

Genomic Location for INTS6L Gene

Chromosome:
X
Start:
135,520,630 bp from pter
End:
135,582,535 bp from pter
Size:
61,906 bases
Orientation:
Plus strand

Genomic View for INTS6L Gene

Genes around INTS6L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INTS6L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INTS6L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INTS6L Gene

Proteins for INTS6L Gene

  • Protein details for INTS6L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JSJ4-DX26B_HUMAN
    Recommended name:
    Protein DDX26B
    Protein Accession:
    Q5JSJ4
    Secondary Accessions:
    • Q5CZA2
    • Q6IPS3
    • Q6ZTU5
    • Q6ZWE4

    Protein attributes for INTS6L Gene

    Size:
    861 amino acids
    Molecular mass:
    96673 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for INTS6L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for INTS6L Gene

Proteomics data for INTS6L Gene at MOPED

Post-translational modifications for INTS6L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for INTS6L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for INTS6L Gene

Domains & Families for INTS6L Gene

Protein Domains for INTS6L Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q5JSJ4

UniProtKB/Swiss-Prot:

DX26B_HUMAN :
  • Contains 1 VWFA domain.
Domain:
  • Contains 1 VWFA domain.
genes like me logo Genes that share domains with INTS6L: view

No data available for Gene Families for INTS6L Gene

Function for INTS6L Gene

genes like me logo Genes that share phenotypes with INTS6L: view

Animal Model Products

miRNA for INTS6L Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for INTS6L Gene

Localization for INTS6L Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for INTS6L Gene

Pathways & Interactions for INTS6L Gene

SuperPathways for INTS6L Gene

No Data Available

Interacting Proteins for INTS6L Gene

Selected Interacting proteins: Q5JSJ4-DX26B_HUMAN for INTS6L Gene via I2D

Gene Ontology (GO) - Biological Process for INTS6L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for INTS6L Gene

Drugs & Compounds for INTS6L Gene

No Compound Related Data Available

Transcripts for INTS6L Gene

Alternative Splicing Database (ASD) splice patterns (SP) for INTS6L Gene

No ASD Table

Relevant External Links for INTS6L Gene

GeneLoc Exon Structure for
INTS6L
ECgene alternative splicing isoforms for
INTS6L

Expression for INTS6L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

genes like me logo Genes that share expression patterns with INTS6L: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for INTS6L Gene

Orthologs for INTS6L Gene

This gene was present in the common ancestor of animals.

Orthologs for INTS6L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC540312 35
  • 93.54 (n)
  • 93.34 (a)
DDX26B 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DDX26B 35
  • 93.34 (n)
  • 93.73 (a)
DDX26B 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ddx26b 35
  • 90.4 (n)
  • 90.36 (a)
Ddx26b 16
Ddx26b 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DDX26B 35
  • 99.69 (n)
  • 99.54 (a)
DDX26B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ddx26b 35
  • 87.04 (n)
  • 84.79 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 59 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 77 (a)
OneToMany
chicken
(Gallus gallus)
Aves DDX26B 35
  • 78.53 (n)
  • 80.23 (a)
-- 36
  • 69 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 71 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx26b 35
  • 72.1 (n)
  • 76.79 (a)
Str.5728 35
zebrafish
(Danio rerio)
Actinopterygii ddx26b 35
  • 65.84 (n)
  • 71.87 (a)
ddx26b 36
  • 67 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta IntS6 35
  • 54.23 (n)
  • 52.73 (a)
IntS6 36
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dic-1 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToMany
Species with no ortholog for INTS6L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for INTS6L Gene

ENSEMBL:
Gene Tree for INTS6L (if available)
TreeFam:
Gene Tree for INTS6L (if available)

Paralogs for INTS6L Gene

genes like me logo Genes that share paralogs with INTS6L: view

Variants for INTS6L Gene

Sequence variations from dbSNP and Humsavar for INTS6L Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs967139 -- 135,563,633(+) TGTGT(A/G)TATAT intron-variant
rs975962 -- 135,549,224(-) TCTGA(C/T)AAAAA intron-variant
rs1397384 -- 135,548,039(-) TTACA(A/C)ATTTA intron-variant
rs1510594 -- 135,549,218(-) AAAAA(C/T)AGATC intron-variant
rs1812552 -- 135,579,498(-) GCTTT(A/T)CAAGT intron-variant

Variation tolerance for INTS6L Gene

Residual Variation Intolerance Score: 19.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.49; 43.61% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for INTS6L Gene

Disorders for INTS6L Gene

Relevant External Links for INTS6L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
INTS6L

No disorders were found for INTS6L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for INTS6L Gene

Publications for INTS6L Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  3. Streamlined analysis schema for high-throughput identification of endogenous protein complexes. (PMID: 20133760) Malovannaya A. … Qin J. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3
  4. A human MAP kinase interactome. (PMID: 20936779) Bandyopadhyay S. … Ideker T. (Nat. Methods 2010) 3
  5. Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. (PMID: 17043677) Camargo L.M. … Brandon N.J. (Mol. Psychiatry 2007) 3

Products for INTS6L Gene

Sources for INTS6L Gene

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