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INTS6 Gene

protein-coding   GIFtS: 50
GCID: GC13M051928

Integrator Complex Subunit 6

(Previous name: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26)
(Previous symbol: DDX26)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Integrator Complex Subunit 61 2     INT62
DDX261 2 3 5     Notchl22
DICE12 3 5     DEAD Box Protein2
DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 261 2     RNA Helicase HDB2
Protein Deleted In Cancer 12 3     DBI13
DBI-12 3     Int63
DDX26A2 3     Protein DDX263
HDB2     

External Ids:    HGNC: 148791   Entrez Gene: 265122   Ensembl: ENSG000001027867   OMIM: 6043315   UniProtKB: Q9UL033   

Export aliases for INTS6 gene to outside databases

Previous GC identifers: GC13M050833 GC13M032724


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for INTS6 Gene:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The
protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus
of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor
suppressor and located in the critical region of loss of heterozygosity (LOH). Three transcript variants encoding
two different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for INTS6 Gene:
INTS6 (integrator complex subunit 6) is a protein-coding gene. GO annotations related to this gene include transmembrane signaling receptor activity. An important paralog of this gene is CT45A4.

UniProtKB/Swiss-Prot: INT6_HUMAN, Q9UL03
Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2
transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal
domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. May
have a tumor suppressor role; an ectopic expression suppressing tumor cell growth

Gene Wiki entry for INTS6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NT_024524.15  NC_018924.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the INTS6 gene promoter:
         NF-1   AML1a   p53   CUTL1   GATA-1   Egr-2   FAC1   S8   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidINTS6 promoter sequence
   Search Chromatin IP Primers for INTS6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat INTS6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14.3   Ensembl cytogenetic band:  13q14.3   HGNC cytogenetic band: 13q14.3

INTS6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INTS6 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M051928:  view genomic region     (about GC identifiers)

Start:
51,928,213 bp from pter      End:
52,028,400 bp from pter
Size:
100,188 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: INT6_HUMAN, Q9UL03 (See protein sequence)
Recommended Name: Integrator complex subunit 6  
Size: 887 amino acids; 100390 Da
Subunit: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5,
INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12
Sequence caution: Sequence=AAH13358.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=AL833524; Type=Erroneous termination; Positions=796; Note=Translated as Gly;
Sequence=CAB56020.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q0P664 Q6PJP4 Q9UFK0 Q9Y5M9
Alternative splicing: 3 isoforms:  Q9UL03-1   Q9UL03-2   Q9UL03-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for INTS6: NX_Q9UL03

Explore proteomics data for INTS6 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See INTS6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001035026.1  NP_001035027.1  NP_036273.1  

    ENSEMBL proteins: 
     ENSP00000417442   ENSP00000310260   ENSP00000381187   ENSP00000419871   ENSP00000419984  
     ENSP00000418026   ENSP00000419287   ENSP00000418080   ENSP00000419144   ENSP00000419569  
     ENSP00000417707   ENSP00000406915   ENSP00000420431   ENSP00000388585   ENSP00000411245  

    INTS6 Human Recombinant Protein Products:

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    Novus Biologicals INTS6 Protein
    Novus Biologicals INTS6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for INTS6

     
    Search eBioscience for Proteins for INTS6 

     
    antibodies-online proteins for INTS6 (2 products) 

     
    antibodies-online peptides for INTS6

    INTS6 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    antibodies-online antibodies for INTS6 (15 products) 

    INTS6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for INTS6
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    antibodies-online kits for INTS6 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DDX: DEAD-boxes

    1 InterPro protein domain:
     IPR002035 VWF_A

    Graphical View of Domain Structure for InterPro Entry Q9UL03

    ProtoNet protein and cluster: Q9UL03

    2 Blocks protein domains:
    IPB000629 ATP-dependent helicase
    IPB002035 Von Willebrand factor type A domain signature


    UniProtKB/Swiss-Prot: INT6_HUMAN, Q9UL03
    Similarity: Belongs to the Integrator subunit 6 family
    Similarity: Contains 1 VWFA domain


    Find genes that share domains with INTS6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: INT6_HUMAN, Q9UL03
    Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2
    transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal
    domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. May
    have a tumor suppressor role; an ectopic expression suppressing tumor cell growth
    Induction: Frequently down-regulated in nonsmall cell lung carcinomas and prostate cancers. Down-regulation in
    prostate cancer is due to CpG hypermethylation of its promoter. However, some involvement in cancer is unclear

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity TAS10467397
    GO:0005515protein binding IPI16239144
         
    Find genes that share ontologies with INTS6           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for INTS6:
     Decreased Hepatitis C virus re  Elongated cells  Increased S DNA content  Increased gamma-H2AX phosphory 
     Wnt reporter downregulated 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Ints6):
     no phenotypic analysis 

    Find genes that share phenotypes with INTS6           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for INTS6

    miRNA
    Products:
        
    miRTarBase miRNAs that target INTS6:
    hsa-mir-155-5p (MIRT020710), hsa-mir-1 (MIRT023673), hsa-mir-30a-5p (MIRT028529)

    Block miRNA regulation of human, mouse, rat INTS6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate INTS6 (see all 134):
    hsa-miR-411* hsa-miR-579 hsa-miR-520f hsa-miR-106a hsa-miR-605 hsa-miR-1245 hsa-miR-3653 hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidINTS6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for INTS6
    Predesigned siRNA for gene silencing in human, mouse, rat INTS6

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): INTS6 (NM_012141)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INTS6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INTS6

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTS6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    INT6_HUMAN, Q9UL03: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton4
    cytosol2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0015629actin cytoskeleton IDA--
    GO:0032039integrator complex IDA16239144

    Find genes that share ontologies with INTS6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for INTS6
    Interactions:

        Search GeneGlobe Interaction Network for INTS6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for INTS6 (Q9UL031, 2, 3 ENSP000003102604) via UniProtKB, MINT, STRING, and/or I2D (see all 596)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UPF2Q9HAU52, 3, ENSP000003487084MINT-4791485 MINT-7947479 I2D: score=1 STRING: ENSP00000348708
    INTS8Q75QN22, 3, ENSP000003432744MINT-7947479 I2D: score=1 STRING: ENSP00000343274
    PPP2R1AP301532, 3, ENSP000003248044MINT-7947479 I2D: score=1 STRING: ENSP00000324804
    UPF1Q929002, 3, ENSP000002628034MINT-7947479 MINT-4791471 I2D: score=1 STRING: ENSP00000262803
    MCM7P339931, 3, ENSP000003072884EBI-1381827,EBI-355924 I2D: score=1 STRING: ENSP00000307288
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS10467397
    GO:0016180snRNA processing IDA16239144

    Find genes that share ontologies with INTS6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for INTS6 (INT6)

    Selected Novoseek inferred chemical compound relationships for INTS6 gene (see all 18)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2-methyltetrahydrofuran 73 1 11154580 (1)
    pyridine 63.6 2 16138383 (1), 20023986 (1)
    fe3+ 57.1 1 17375912 (1)
    toluene 53 1 15558123 (1)
    carboxylate 49.5 1 16999412 (1)
    platinum 48.3 2 17378566 (1)
    amine 40.4 1 15010790 (1)
    chloride 36.9 2 19081976 (1)
    acetonitrile 35.5 1 15558123 (1)
    methylene 33.8 1 12580610 (1)



    Find genes that share compounds with INTS6           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for INTS6 gene (3 alternative transcripts): 
    NM_001039937.1  NM_001039938.1  NM_012141.2  

    Unigene Cluster for INTS6:

    Integrator complex subunit 6
    Hs.439440  [show with all ESTs]
    Unigene Representative Sequence: NM_012141
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000476666 ENST00000469430(uc001vfl.3) ENST00000311234(uc001vfk.3)
    ENST00000398119(uc001vfj.3) ENST00000497989 ENST00000483441(uc001vfi.3)
    ENST00000490542 ENST00000493153 ENST00000483746 ENST00000460868 ENST00000486195
    ENST00000491189 ENST00000466784 ENST00000491723 ENST00000461515 ENST00000491997
    ENST00000488009 ENST00000485178
    miRNA
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    Block miRNA regulation of human, mouse, rat INTS6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate INTS6 (see all 134):
    hsa-miR-411* hsa-miR-579 hsa-miR-520f hsa-miR-106a hsa-miR-605 hsa-miR-1245 hsa-miR-3653 hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidINTS6 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): INTS6 (NM_012141)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INTS6
    Primer
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    OriGene qPCR primer pairs and template standards for INTS6
    OriGene qSTAR qPCR primer pairs in human, mouse for INTS6
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      QuantiTect SYBR Green Assays in human, mouse, rat INTS6
      QuantiFast Probe-based Assays in human, mouse, rat INTS6

    Additional mRNA sequence: 

    AF086440.1 AF097645.1 AF141326.1 AK074946.1 AK094036.1 AK096696.1 AK128795.1 AK296801.1 
    AK303869.1 AK304218.1 AL117626.1 AL833524.1 BC013358.2 BC018725.1 BC032386.1 BC039829.1 
    BC040581.1 BC094745.1 

    22 DOTS entries:

    DT.101983296  DT.100773965  DT.65284315  DT.413698  DT.120779846  DT.413699  DT.101968427  DT.95338085 
    DT.91755039  DT.120779872  DT.95337789  DT.40213822  DT.425233  DT.100026059  DT.86859408  DT.91755041 
    DT.91856684  DT.95164018  DT.40130833  DT.91922519  DT.99944745  DT.99981820 

    Selected AceView cDNA sequences (see all 190):

    BX280278 AI708074 BC039829 W81340 AA490830 BX116410 BU754286 CA407016 
    BC018725 AA507464 AA349076 AA405143 AI741381 BE408490 CD359043 CA389942 
    BM552659 BU621361 AF086440 AI363122 AA135071 BM721372 CA436828 CB134637 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for INTS6 (see all 16)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13 ^
    SP1:                                      -     -     -     -     -           -     -                       -     -     -     -     -                           
    SP2:                                      -     -     -     -     -           -     -                       -     -     -     -     -                           
    SP3:                                                                                                                                                            
    SP4:              -     -     -           -     -     -     -     -           -     -                       -     -     -     -     -                           
    SP5:                                      -     -     -     -     -           -     -                                                                           

    ExUns: 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27
    SP1:              -     -                                                                                 
    SP2:              -     -                                                                                 
    SP3:              -     -                                                                                 
    SP4:                                                                                                      
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for INTS6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    INTS6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    INTS6 Expression
    About this image


    INTS6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Testis (Reproductive System)
    INTS6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    INTS6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.439440

    UniProtKB/Swiss-Prot: INT6_HUMAN, Q9UL03
    Tissue specificity: Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney
    and pancreas

        Custom PCR Arrays for INTS6
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for INTS6 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ints61 , 5 integrator complex subunit 61, 5 92.68(n)1
    96.38(a)1
      14 (33.23 cM)5
    181301  NM_008715.21  NP_032741.21 
     626763305 
    chicken
    (Gallus gallus)
    Aves INTS61 integrator complex subunit 6 82.39(n)
    86.09(a)
      418876  XM_417071.4  XP_417071.3 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.107942 Transcribed sequence with moderate similarity to protein more 78.94(n)    BX741028.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.114872 Danio rerio cDNA clone IMAGE3817882, containing frame-shift more 75.82(n)    BC059197.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta IntS66
    Integrator 6
    25(a)
    1 → many
    X(5632696-5641287)
    worm
    (Caenorhabditis elegans)
    Secernentea dic-16
    Protein DIC-1, isoform b
    24(a)
    1 → many
    IV(8692099-8696456) WBGene00000994


    ENSEMBL Gene Tree for INTS6 (if available)
    TreeFam Gene Tree for INTS6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for INTS6 gene
    CT45A42  CT45A32  CT45A22  CT45A52  CT45A12  SAGE12  CT45A62  DDX26B2  
    1 SIMAP similar gene for INTS6 using alignment to 13 protein entries:     INT6_HUMAN (see all proteins):
    DDX26B

    Find genes that share paralogs with INTS6           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for INTS6
    PGOHUM00000259976 PGOHUM00000259977 PGOHUM00000235198 PGOHUM00000242032


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for INTS6 (see all 1623)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1892781151,2
    --51936868(+) TTATGC/TATAGT 2 -- ut310--------
    rs1813151391,2
    --51936877(+) GTTTTA/GCATAA 2 -- ut310--------
    rs95356511,2
    C,F,H--51937090(+) ACCACA/GTAACG 2 -- ut3114Minor allele frequency- G:0.04NS EA NA 1104
    rs2010917481,2
    C--51937507(+) ACACA-/ACACAGT 2 -- ut310--------
    rs1865056881,2
    --51937542(+) TGGAAG/TAGTTT 2 -- ut310--------
    rs1914428831,2
    --51937998(+) CAGAAA/GAATGT 2 -- ut310--------
    rs128705771,2
    H--51938009(+) ATTAAA/CGGTCA 2 -- ut314Minor allele frequency- C:0.00NS EA 420
    rs1512464801,2
    --51938101(+) GATACC/TCTTGT 2 -- ut310--------
    rs1404658791,2
    C--51938150(+) CTAGTA/GATTCC 2 -- ut310--------
    rs1829453691,2
    --51938253(+) CCTTAA/TCAATT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for INTS6 (51928213 - 52028400 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for INTS6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832611CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing INTS6
    DNA2.0 Custom Variant and Variant Library Synthesis for INTS6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604331    OMIM disorders: --


    Find genes that share disorders with INTS6           About GenesLikeMe

    8 Novoseek inferred disease relationships for INTS6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma non-small cell lung 28.8 5 15254679 (2), 10467397 (2)
    endometrial carcinoma 26.6 1 12708483 (1)
    allelic loss 26 2 10467397 (1)
    retinoblastoma 6.57 1 9508208 (1)
    tumors 0 8 15254679 (2), 16007164 (2), 10467397 (1), 17085174 (1)
    carcinoma 0 7 16256201 (1), 9159337 (1), 10467397 (1)
    cancer 0 4 19906297 (1), 18293353 (1)
    hyperplasia 0 8 10652418 (1), 12708483 (1), 9159337 (1)


    Export disorders for INTS6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for INTS6 gene, integrated from 10 sources (see all 124):
    (articles sorted by number of sources associating them with INTS6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of DICE1: a gene frequently affected by LOH and downregulated in lung carcinomas. (PubMed id 10467397)1, 2, 3, 9 Wieland I.... Weidle U.H. (Oncogene 1999)
    2. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PubMed id 16239144)1, 2, 3 Baillat D....Shiekhattar R. (Cell 2005)
    3. Promoter CpG hypermethylation and downregulation of DICE1 expression in prostate cancer. (PubMed id 16007164)1, 2, 9 Roepke A....Wieacker P.F. (Oncogene 2005)
    4. Ectopic expression of DICE1 suppresses tumor cell growth. (PubMed id 15254679)1, 2, 9 Wieland I.... Wieacker P. (Oncol. Rep. 2004)
    5. Absence of mutations in DICE1/DDX26 gene in human cancer cell lines with frequent 13q14 deletions. (PubMed id 16271964)1, 2 Hernandez M.... Almeida T.A. (Cancer Genet. Cytogenet. 2005)
    6. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (Nature 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Molecular characterization of the DICE1 (DDX26) tumor suppressor gene in lung carcinoma cells. (PubMed id 11939413)1, 2 Wieland I.... Wieacker P.F. (Oncol. Res. 2001)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. Targeting of DICE1 tumor suppressor by Epstein-Barr virus-encoded miR-BART3* microRNA in nasopharyngeal carcinoma. (PubMed id 23280823)1 Lei T....Jin D.Y. (Int. J. Cancer 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26512 HGNC: 14879 AceView: DDX26 Ensembl:ENSG00000102786 euGenes: HUgn26512
    ECgene: INTS6 H-InvDB: INTS6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for INTS6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for INTS6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for INTS6 gene:
    Search GeneIP for patents involving INTS6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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