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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

INTS6 Gene

protein-coding   GIFtS: 50
GCID: GC13M051928

Integrator Complex Subunit 6

(Previous name: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26)
(Previous symbol: DDX26)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Integrator Complex Subunit 61 2     INT62
DDX261 2 3 5     Notchl22
DICE12 3 5     DEAD Box Protein2
DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 261 2     RNA Helicase HDB2
Protein Deleted In Cancer 12 3     DBI13
DBI-12 3     Int63
DDX26A2 3     Protein DDX263
HDB2     

External Ids:    HGNC: 148791   Entrez Gene: 265122   Ensembl: ENSG000001027867   OMIM: 6043315   UniProtKB: Q9UL033   

Export aliases for INTS6 gene to outside databases

Previous GC identifers: GC13M050833 GC13M032724


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for INTS6 Gene:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The
protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus
of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor
suppressor and located in the critical region of loss of heterozygosity (LOH). Three transcript variants encoding
two different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for INTS6 Gene: 
INTS6 (integrator complex subunit 6) is a protein-coding gene. Diseases associated with INTS6 include 21-hydroxylase deficiency, and endometrial carcinoma. GO annotations related to this gene include transmembrane signaling receptor activity and protein binding. An important paralog of this gene is CT45A2.

UniProtKB/Swiss-Prot: INT6_HUMAN, Q9UL03
Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2
transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal
domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. May
have a tumor suppressor role; an ectopic expression suppressing tumor cell growth

Gene Wiki entry for INTS6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NT_024524.14  NC_018924.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the INTS6 gene promoter:
         NF-1   AML1a   p53   CUTL1   GATA-1   Egr-2   FAC1   S8   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidINTS6 promoter sequence
   Search SABiosciences Chromatin IP Primers for INTS6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INTS6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14.3   Ensembl cytogenetic band:  13q14.3   HGNC cytogenetic band: 13q14.3

INTS6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INTS6 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M051928:  view genomic region     (about GC identifiers)

Start:
51,928,213 bp from pter      End:
52,028,400 bp from pter
Size:
100,188 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: INT6_HUMAN, Q9UL03 (See protein sequence)
Recommended Name: Integrator complex subunit 6  
Size: 887 amino acids; 100390 Da
Subunit: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5,
INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12
Subcellular location: Nucleus
Sequence caution: Sequence=AAH13358.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=AL833524; Type=Erroneous termination; Positions=796; Note=Translated as Gly;
Sequence=CAB56020.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q0P664 Q6PJP4 Q9UFK0 Q9Y5M9
Alternative splicing: 3 isoforms:  Q9UL03-1   Q9UL03-2   Q9UL03-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for INTS6: NX_Q9UL03

Explore proteomics data for INTS6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UL03

  • INTS6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    INTS6 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001035026.1  NP_001035027.1  NP_036273.1  

    ENSEMBL proteins: 
     ENSP00000417442   ENSP00000310260   ENSP00000381187   ENSP00000419871   ENSP00000419984  
     ENSP00000418026   ENSP00000419287   ENSP00000418080   ENSP00000419144   ENSP00000419569  
     ENSP00000417707   ENSP00000406915   ENSP00000420431   ENSP00000388585   ENSP00000411245  

    Human Recombinant Protein Products for INTS6: 
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    Novus Biologicals INTS6 Protein
    Novus Biologicals INTS6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for INTS6 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0015629actin cytoskeleton IDA--
    GO:0032039integrator complex IDA16239144

    INTS6 for ontologies           About GeneDecksing



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    LSBio Antibodies in human, mouse, rat for INTS6 

    Assay Products for INTS6: 
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    Cloud-Clone Corp. ELISAs for INTS6 
    Cloud-Clone Corp. CLIAs for INTS6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    DDX: DEAD-boxes

    1 InterPro protein domain:
     IPR002035 VWF_A

    Graphical View of Domain Structure for InterPro Entry Q9UL03

    ProtoNet protein and cluster: Q9UL03

    2 Blocks protein domains:
    IPB000629 ATP-dependent helicase
    IPB002035 Von Willebrand factor type A domain signature


    UniProtKB/Swiss-Prot: INT6_HUMAN, Q9UL03
    Similarity: Belongs to the Integrator subunit 6 family
    Similarity: Contains 1 VWFA domain


    INTS6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: INT6_HUMAN, Q9UL03
    Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2
    transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal
    domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. May
    have a tumor suppressor role; an ectopic expression suppressing tumor cell growth
    Induction: Frequently down-regulated in nonsmall cell lung carcinomas and prostate cancers. Down-regulation in
    prostate cancer is due to CpG hypermethylation of its promoter. However, some involvement in cancer is unclear

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity TAS10467397
    GO:0005515protein binding IPI16239144
         
    INTS6 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for INTS6:
     Decreased Hepatitis C virus re  Elongated cells  Increased S DNA content  Increased gamma-H2AX phosphory 
     Wnt reporter downregulated 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Ints6):
     no phenotypic analysis 

    INTS6 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for INTS6 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for INTS6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for INTS6 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for INTS6 

    miRNA
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    8/134 QIAGEN miScript miRNA Assays for microRNAs that regulate INTS6 (see all 134):
    hsa-miR-411* hsa-miR-579 hsa-miR-520f hsa-miR-106a hsa-miR-605 hsa-miR-1245 hsa-miR-3653 hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidINTS6 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTS6


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for INTS6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/596 Interacting proteins for INTS6 (Q9UL031, 2, 3 ENSP000003102604) via UniProtKB, MINT, STRING, and/or I2D (see all 596)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UPF2Q9HAU52, 3, ENSP000003487084MINT-4791485 MINT-7947479 I2D: score=1 STRING: ENSP00000348708
    INTS8Q75QN22, 3, ENSP000003432744MINT-7947479 I2D: score=1 STRING: ENSP00000343274
    PPP2R1AP301532, 3, ENSP000003248044MINT-7947479 I2D: score=1 STRING: ENSP00000324804
    UPF1Q929002, 3, ENSP000002628034MINT-7947479 MINT-4791471 I2D: score=1 STRING: ENSP00000262803
    MCM7P339931, 3, ENSP000003072884EBI-1381827,EBI-355924 I2D: score=1 STRING: ENSP00000307288
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016180snRNA processing IDA16239144

    INTS6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    INTS6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for INTS6 (INT6)

    10/18 Novoseek inferred chemical compound relationships for INTS6 gene (see all 18)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2-methyltetrahydrofuran 73 1 11154580 (1)
    pyridine 63.6 2 16138383 (1), 20023986 (1)
    fe3+ 57.1 1 17375912 (1)
    toluene 53 1 15558123 (1)
    carboxylate 49.5 1 16999412 (1)
    platinum 48.3 2 17378566 (1)
    amine 40.4 1 15010790 (1)
    chloride 36.9 2 19081976 (1)
    acetonitrile 35.5 1 15558123 (1)
    methylene 33.8 1 12580610 (1)

    Search CenterWatch for drugs/clinical trials and news about INTS6 / INT6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for INTS6 gene (3 alternative transcripts): 
    NM_001039937.1  NM_001039938.1  NM_012141.2  

    Unigene Cluster for INTS6:

    Integrator complex subunit 6
    Hs.439440  [show with all ESTs]
    Unigene Representative Sequence: NM_012141
    18/24 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000476666 ENST00000469430(uc001vfl.3) ENST00000311234(uc001vfk.3)
    ENST00000398119(uc001vfj.3) ENST00000497989 ENST00000483441(uc001vfi.3)
    ENST00000490542 ENST00000493153 ENST00000483746 ENST00000460868 ENST00000486195
    ENST00000491189 ENST00000466784 ENST00000491723 ENST00000461515 ENST00000491997
    ENST00000488009 ENST00000485178
    miRNA
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    8/134 QIAGEN miScript miRNA Assays for microRNAs that regulate INTS6 (see all 134):
    hsa-miR-411* hsa-miR-579 hsa-miR-520f hsa-miR-106a hsa-miR-605 hsa-miR-1245 hsa-miR-3653 hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidINTS6 3' UTR sequence
    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INTS6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INTS6
    Sirion Biotech Customized lentivirus for stable overexpression of INTS6 
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    OriGene qPCR primer pairs and template standards for INTS6
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INTS6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INTS6

    Additional mRNA sequence: 

    AF086440.1 AF097645.1 AF141326.1 AK074946.1 AK094036.1 AK096696.1 AK128795.1 AK296801.1 
    AK303869.1 AK304218.1 AL117626.1 AL833524.1 BC013358.2 BC018725.1 BC032386.1 BC039829.1 
    BC040581.1 BC094745.1 

    22 DOTS entries:

    DT.101983296  DT.100773965  DT.65284315  DT.413698  DT.120779846  DT.413699  DT.101968427  DT.95338085 
    DT.91755039  DT.120779872  DT.95337789  DT.40213822  DT.425233  DT.100026059  DT.86859408  DT.91755041 
    DT.91856684  DT.95164018  DT.40130833  DT.91922519  DT.99944745  DT.99981820 

    24/190 AceView cDNA sequences (see all 190):

    BM552659 BC018725 AL117626 BM721372 BU740446 CR607963 CB134637 BM699545 
    W81340 AA507464 AW502252 AI741381 BX116410 AI708074 BX280278 AL596988 
    BI827749 BM787810 AA490830 AK074946 CD359043 BM473498 AW504624 BM544948 

    GeneLoc Exon Structure

    5/16 Alternative Splicing Database (ASD) splice patterns (SP) for INTS6 (see all 16)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13 ^
    SP1:                                      -     -     -     -     -           -     -                       -     -     -     -     -                           
    SP2:                                      -     -     -     -     -           -     -                       -     -     -     -     -                           
    SP3:                                                                                                                                                            
    SP4:              -     -     -           -     -     -     -     -           -     -                       -     -     -     -     -                           
    SP5:                                      -     -     -     -     -           -     -                                                                           

    ExUns: 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27
    SP1:              -     -                                                                                 
    SP2:              -     -                                                                                 
    SP3:              -     -                                                                                 
    SP4:                                                                                                      
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for INTS6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    INTS6 expression in normal human tissues (normalized intensities)      INTS6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    INTS6 Expression
    About this image


    INTS6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/35 selected tissues (see all 35) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             seminal vesicle ; glandular cells   

    See INTS6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for INTS6

    SOURCE GeneReport for Unigene cluster: Hs.439440

    UniProtKB/Swiss-Prot: INT6_HUMAN, Q9UL03
    Tissue specificity: Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney
    and pancreas

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for INTS6 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ints61 , 5 integrator complex subunit 61, 5 92.68(n)1
    96.38(a)1
      14 (33.23 cM)5
    181301  NM_008715.21  NP_032741.21 
     626763305 
    chicken
    (Gallus gallus)
    Aves INTS61 integrator complex subunit 6 82.39(n)
    86.09(a)
      418876  XM_417071.3  XP_417071.3 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.107942 Transcribed sequence with moderate similarity to protein more 78.94(n)    BX741028.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.114872 Danio rerio cDNA clone IMAGE3817882, containing frame-shift more 75.82(n)    BC059197.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta IntS66
    Integrator 6
    24(a)
    1 → many
    X(5632696-5641287)
    worm
    (Caenorhabditis elegans)
    Secernentea dic-16
    Protein DIC-1, isoform b
    20(a)
    1 → many
    IV(8692099-8696456)


    ENSEMBL Gene Tree for INTS6 (if available)
    TreeFam Gene Tree for INTS6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for INTS6 gene
    CT45A22  CT45A52  CT45A12  SAGE12  CT45A42  CT45A62  DDX26B2  CT45A32  
    1 SIMAP similar gene for INTS6 using alignment to 13 protein entries:     INT6_HUMAN (see all proteins):
    DDX26B

    INTS6 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for INTS6
    PGOHUM00000259976 PGOHUM00000259977 PGOHUM00000235198 PGOHUM00000242032


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1623 SNPs in INTS6 are shown (see all 1623)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1892781151,2
    --51936868(+) TTATGC/TATAGT 2 -- ut310--------
    rs1813151391,2
    --51936877(+) GTTTTA/GCATAA 2 -- ut310--------
    rs95356511,2
    C,F,H--51937090(+) ACCACA/GTAACG 2 -- ut3114Minor allele frequency- G:0.04NS EA NA 1104
    rs2010917481,2
    C--51937507(+) ACACA-/ACACAGT 2 -- ut310--------
    rs1865056881,2
    --51937542(+) TGGAAG/TAGTTT 2 -- ut310--------
    rs1914428831,2
    --51937998(+) CAGAAA/GAATGT 2 -- ut310--------
    rs128705771,2
    H--51938009(+) ATTAAA/CGGTCA 2 -- ut314Minor allele frequency- C:0.00NS EA 420
    rs1512464801,2
    --51938101(+) GATACC/TCTTGT 2 -- ut310--------
    rs1404658791,2
    C--51938150(+) CTAGTA/GATTCC 2 -- ut310--------
    rs1829453691,2
    --51938253(+) CCTTAA/TCAATT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for INTS6 (51928213 - 52028400 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for INTS6:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv832611CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604331    OMIM disorders: --

    12 diseases for INTS6:    About MalaCards
    21-hydroxylase deficiency    endometrial carcinoma    abdominal aortic aneurysm    aortic aneurysm
    non-small cell lung carcinoma    esophageal squamous cell carcinoma    retinoblastoma    esophagitis
    squamous cell carcinoma    alcoholism    prostate cancer    prostatitis


    INTS6 for disorders           About GeneDecksing

    8 Novoseek inferred disease relationships for INTS6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma non-small cell lung 28.8 5 15254679 (2), 10467397 (2)
    endometrial carcinoma 26.6 1 12708483 (1)
    allelic loss 26 2 10467397 (1)
    retinoblastoma 6.57 1 9508208 (1)
    tumors 0 8 15254679 (2), 16007164 (2), 10467397 (1), 17085174 (1)
    carcinoma 0 7 16256201 (1), 9159337 (1), 10467397 (1)
    cancer 0 4 19906297 (1), 18293353 (1)
    hyperplasia 0 8 10652418 (1), 12708483 (1), 9159337 (1)


    Export disorders for INTS6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for INTS6 gene, integrated from 9 sources (see all 122):
    (articles sorted by number of sources associating them with INTS6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of DICE1: a gene frequently affected by LOH and downregulated in lung carcinomas. (PubMed id 10467397)1, 2, 3, 9 Wieland I.... Weidle U.H. (1999)
    2. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PubMed id 16239144)1, 2, 3 Baillat D....Shiekhattar R. (2005)
    3. Promoter CpG hypermethylation and downregulation of DICE1 expression in prostate cancer. (PubMed id 16007164)1, 2, 9 Roepke A....Wieacker P.F. (2005)
    4. Ectopic expression of DICE1 suppresses tumor cell growth. (PubMed id 15254679)1, 2, 9 Wieland I.... Wieacker P. (2004)
    5. Absence of mutations in DICE1/DDX26 gene in human cancer cell lines with frequent 13q14 deletions. (PubMed id 16271964)1, 2 Hernandez M.... Almeida T.A. (2005)
    6. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Molecular characterization of the DICE1 (DDX26) tumor suppressor gene in lung carcinoma cells. (PubMed id 11939413)1, 2 Wieland I.... Wieacker P.F. (2000)
    9. Targeting of DICE1 tumor suppressor by Epstein-Barr vi rus-encoded miR-BART3* microRNA in nasopharyngeal carcinoma. (PubMed id 23280823)1 Lei T....Jin D.Y. (2013)
    10. Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration. (PubMed id 22360420)1 Martins-de-Souza D....Bahn S. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26512 HGNC: 14879 AceView: DDX26 Ensembl:ENSG00000102786 euGenes: HUgn26512
    ECgene: INTS6 H-InvDB: INTS6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for INTS6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for INTS6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for INTS6 gene:
    Search GeneIP for patents involving INTS6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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