INTS6 Gene
protein-coding GIFtS: 48
GCID: GC13M051928
|
|
integrator complex subunit 6(Previous name: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26 )
(Previous symbol: DDX26)
| |
Aliases
for INTS6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Integrator Complex Subunit 61 2 | | DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 261 2 | | DDX261 2 3 5 | | Protein Deleted In Cancer 12 3 | | DICE11 2 3 5 | | DEAD Box Protein2 | | DBI-11 2 3 | | RNA Helicase HDB2 | | DDX26A1 2 3 | | DBI13 | | HDB1 2 | | Int63 | | INT61 2 | | Protein DDX263 | | Notchl21 2 | | |
Export aliases for INTS6 gene to outside databasesPrevious GC identifers: GC13M050833 GC13M032724 |
Summaries
for INTS6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for INTS6:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The proteinencoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNApolymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressorand located in the critical region of loss of heterozygosity (LOH). Three transcript variants encoding two differentisoforms have been found for this gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: INT6_HUMAN, Q9UL03Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminaldomain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. May have atumor suppressor role; an ectopic expression suppressing tumor cell growth
Gene Wiki entry for INTS6
|
Genomic Views
for INTS6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_024524.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the INTS6 gene promoter:
NF-1 AML1a p53 CUTL1 GATA-1 Egr-2 FAC1 S8 FOXO1a FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for INTS6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INTS6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q14.3 Ensembl cytogenetic band: 13q14.3 HGNC cytogenetic band: 13q14.3INTS6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13M051928: view genomic region
(about GC identifiers)
Start:
|
51,928,213 bp from pter |
End:
|
52,028,400 bp from pter |
Size:
|
100,188 bases |
Orientation:
|
minus strand |
|
Proteins
for INTS6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: INT6_HUMAN, Q9UL03 (See
protein sequence)Recommended Name: Integrator complex subunit 6 Size: 887 amino acids; 100390 Da
Subunit: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6,INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12
Subcellular location: Nucleus
Sequence caution: Sequence=AAH13358.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-Asequence; Sequence=AL833524; Type=Erroneous termination; Positions=796; Note=Translated as Gly; Sequence=CAB56020.1;Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q0P664 Q6PJP4 Q9UFK0 Q9Y5M9Alternative splicing: 3 isoforms: Q9UL03-1 Q9UL03-2 Q9UL03-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for INTS6: NX_Q9UL03
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UL03
INTS6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001035026.1 NP_001035027.1 NP_036273.1
ENSEMBL proteins: ENSP00000417442 ENSP00000310260 ENSP00000381187 ENSP00000419871 ENSP00000419984 ENSP00000420431 ENSP00000418026 ENSP00000419287 ENSP00000418080 ENSP00000419144 ENSP00000419569 ENSP00000417707 ENSP00000406915 ENSP00000388585 ENSP00000411245
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
INTS6 for ontologies About GeneDecksing
INTS6 Antibody Products:
Assay Products for INTS6: |
Protein
Domains /
Families
for INTS6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
INTS6 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9UL03ProtoNet protein and cluster: Q9UL03 2 Blocks protein families: IPB000629 ATP-dependent helicase IPB002035 Von Willebrand factor type A domain signature
UniProtKB/Swiss-Prot: INT6_HUMAN, Q9UL03Similarity: Belongs to the Integrator subunit 6 familySimilarity: Contains 1 VWFA domain |
Function
for INTS6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: INT6_HUMAN, Q9UL03Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminaldomain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. May have atumor suppressor role; an ectopic expression suppressing tumor cell growthInduction: Frequently down-regulated in nonsmall cell lung carcinomas and prostate cancers. Down-regulation in prostatecancer is due to CpG hypermethylation of its promoter. However, some involvement in cancer is unclear
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for INTS6 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for INTS6 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): INTS6 (NM_012141) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for INTS6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INTS6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTS6 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
INTS6 for ontologies About GeneDecksing
5 GenomeRNAi human phenotypes for INTS6:
Animal Models:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Ints6):
INTS6 for phenotypes About GeneDecksing
|
Pathways & Interactions
for INTS6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for INTS6
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/569 Interacting proteins for INTS6 (Q9UL031, 2, 3 ENSP000003102604) via UniProtKB, MINT, STRING, and/or I2D (see all 569)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| UPF2 | Q9HAU52, 3, ENSP000003487084 | MINT-4791485 MINT-7947479 I2D:
score=1 STRING: ENSP00000348708 | | INTS8 | Q75QN22, 3, ENSP000003432744 | MINT-7947479 I2D:
score=1 STRING: ENSP00000343274 | | PPP2R1A | P301532, 3, ENSP000003248044 | MINT-7947479 I2D:
score=1 STRING: ENSP00000324804 | | UPF1 | Q929002, 3, ENSP000002628034 | MINT-7947479 MINT-4791471 I2D:
score=1 STRING: ENSP00000262803 | | MCM7 | P339931, 3, ENSP000003072884 | EBI-1381827,EBI-355924 I2D:
score=1 STRING: ENSP00000307288 |
About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
INTS6 for ontologies About GeneDecksing
|
Drugs & Compounds
for INTS6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
INTS6 for compounds About GeneDecksing
 Browse Tocris compounds for INTS6
10/18 Novoseek chemical compound relationships for INTS6 gene (see all 18) About this table
Search CenterWatch for drugs/clinical trials and news about INTS6 / INT6
|
Transcripts
for INTS6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for INTS6 gene (3 alternative transcripts): NM_001039937.1 NM_001039938.1 NM_012141.2 Unigene Cluster for INTS6: Integrator complex subunit 6 Hs.439440 [show with all ESTs]Unigene Representative Sequence: NM_01214118/24 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24): ENST00000476666 ENST00000469430(uc001vfl.3) ENST00000311234(uc001vfk.3)
ENST00000398119(uc001vfj.3) ENST00000497989 ENST00000483441(uc001vfi.3)
ENST00000490542 ENST00000463928 ENST00000493153 ENST00000483746 ENST00000460868
ENST00000486195 ENST00000491189 ENST00000466784 ENST00000491723 ENST00000461515
ENST00000491997 ENST00000488009
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for INTS6 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for INTS6 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): INTS6 (NM_012141) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for INTS6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INTS6 |
Additional cDNA sequence: AF086440.1 AF097645.1 AF141326.1 AK074946.1 AK094036.1 AK096696.1 AK128795.1 AK296801.1 AK303869.1 AK304218.1 AL117626.1 AL833524.1 BC013358.2 BC018725.1 BC032386.1 BC039829.1 BC040581.1 BC094745.1 21 DOTS entries: DT.101983296 DT.100773965 DT.65284315 DT.413698 DT.120779846 DT.413699 DT.101968427 DT.95338085 DT.91755039 DT.120779872 DT.95337789 DT.425233 DT.40213822 DT.100026059 DT.86859408 DT.91755041 DT.91856684 DT.95164018 DT.40130833 DT.91922519 DT.99944745 24/190 AceView cDNA sequences (see all 190): AI253593 AK074946 AL833524 BM473498 BU740446 BC032386 AK096696 AW504624 AI708074 AW502252 CD359043 AA960908 BM787810 AL117626 CA436828 BX644282 AL596988 AK094036 CB134637 CA389942 BM699545 BM552659 BC039829 BU621361
GeneLoc Exon Structure
5/16 Alternative Splicing Database (ASD) splice patterns (SP) for INTS6 (see all 16) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b | · | 12c | ^ | 13 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | - | | - | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | - | | - | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | - | | - | | - | | | | - | | - | | - | | - | | - | | | | - | | - | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19 | ^ | 20a | · | 20b | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 |
|---|
|
| SP1: | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for INTS6
|
Expression
for INTS6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| INTS6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See INTS6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for INTS6
SOURCE GeneReport for Unigene cluster: Hs.439440
UniProtKB/Swiss-Prot: INT6_HUMAN, Q9UL03Tissue specificity: Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney andpancreas
SABiosciences Custom PCR Arrays for INTS6
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for INTS6
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat INTS6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INTS6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INTS6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTS6 |
Orthologs
for INTS6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for INTS6 gene from 5/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
INTS61 |
integrator complex subunit 6 |
82.39(n)
86.09(a) |
|
418876 XM_417071.3 XP_417071.3 |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.107942 |
Transcribed sequence with moderate similarity to protein more |
78.94(n) |
|
BX741028.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.114872 |
Danio rerio cDNA clone IMAGE3817882, containing frame-shift more |
75.82(n) |
|
BC059197.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
IntS66 |
Integrator 6 |
25(a) |
1 → many |
X(5632696-5641287) |
worm
(Caenorhabditis elegans) |
Secernentea |
dic-16 |
-- |
24(a) |
1 → many |
IV(8692086-8696443) |
ENSEMBL Gene Tree for INTS6 (if available)
TreeFam Gene Tree for INTS6 (if available) |
Paralogs
for INTS6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for INTS6 gene
- CT45A22 CT45A52 CT45A12 SAGE12 CT45A42 CT45A62 DDX26B2 CT45A32
1 SIMAP similar gene for INTS6 using alignment to 13 protein entries: INT6_HUMAN (see all proteins):DDX26B
INTS6 for paralogs About GeneDecksing
4 Pseudogenes.org Pseudogenes for INTS6
PGOHUM00000259976 PGOHUM00000259977 PGOHUM00000235198 PGOHUM00000242032
|
Genomic Variants
for INTS6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for INTS6 (51928213 - 52028400 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for INTS6: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing INTS6 |
|
Disorders
/ Diseases
for INTS6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
INTS6 for disorders About GeneDecksing
OMIM gene information: 604331
OMIM disorders: --
14  diseases for INTS6: About MalaCards21-hydroxylase deficiency non-small cell lung carcinoma abdominal aortic aneurysm aortic aneurysm
esophageal squamous cell carcinoma squamous cell carcinoma endometrial carcinoma lung carcinoma
carcinoma seizures esophagitis prostate cancer
prostatitis alcoholism
8 Novoseek disease relationships for INTS6 gene About this table
Export disorders for INTS6 gene to outside databases
|
Publications
for INTS6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for INTS6 gene, integrated from 9 sources (see all 120):
(articles sorted by number of sources associating them with INTS6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Isolation of DICE1: a gene frequently affected by LOH and downregulated in lung carcinomas. (PubMed id 10467397)1, 2, 3, 9 Wieland I.... Weidle U.H. (1999)
- Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PubMed id 16239144)1, 2, 3 Baillat D....Shiekhattar R. (2005)
- Promoter CpG hypermethylation and downregulation of DICE1 expression in prostate cancer. (PubMed id 16007164)1, 2, 9 Roepke A....Wieacker P.F. (2005)
- Ectopic expression of DICE1 suppresses tumor cell growth. (PubMed id 15254679)1, 2, 9 Wieland I.... Wieacker P. (2004)
- Absence of mutations in DICE1/DDX26 gene in human cancer cell lines with frequent 13q14 deletions. (PubMed id 16271964)1, 2 Hernandez M.... Almeida T.A. (2005)
- The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Molecular characterization of the DICE1 (DDX26) tumor suppressor gene in lung carcinoma cells. (PubMed id 11939413)1, 2 Wieland I.... Wieacker P.F. (2000)
- Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration. (PubMed id 22360420)1 Martins-de-Souza D....Bahn S. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
|
External Searches for INTS6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing INTS6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing INTS6 gene
(According to HUGE)
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Specialized Databases showing INTS6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for INTS6 gene:
Search GeneIP for patents involving INTS6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for INTS6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for INTS6 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for INTS6 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for INTS6 | | | OriGene Protein Over-expression Lysate for INTS6 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for INTS6 | | OriGene 3'-UTR Clone for INTS6 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for INTS6 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for INTS6 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for INTS6 | | OriGene Custom Protein Services for INTS6 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat INTS6 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing INTS6 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INTS6 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat INTS6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INTS6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INTS6 |
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| | | | Search Tocris compounds for INTS6 |
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 | | | INTS6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTS6 |
|  |  |  | | | | Search ThermoFisher Antibodies for INTS6 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INTS6 |
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