Free for academic non-profit institutions. Other users need a Commercial license

Aliases for INTS6 Gene

Aliases for INTS6 Gene

  • Integrator Complex Subunit 6 2 3
  • DDX26 3 4 6
  • DICE1 3 4 6
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 26 2 3
  • Protein Deleted In Cancer 1 3 4
  • DDX26A 3 4
  • DBI-1 3 4
  • INT6 3 4
  • DEAD Box Protein 3
  • RNA Helicase HDB 3
  • Protein DDX26 4
  • Notchl2 3
  • DBI1 4
  • HDB 3

External Ids for INTS6 Gene

Previous HGNC Symbols for INTS6 Gene

  • DDX26

Previous GeneCards Identifiers for INTS6 Gene

  • GC13M050833
  • GC13M051928
  • GC13M032724

Summaries for INTS6 Gene

Entrez Gene Summary for INTS6 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and located in the critical region of loss of heterozygosity (LOH). Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for INTS6 Gene

INTS6 (Integrator Complex Subunit 6) is a Protein Coding gene. GO annotations related to this gene include transmembrane signaling receptor activity. An important paralog of this gene is DDX26B.

UniProtKB/Swiss-Prot for INTS6 Gene

  • Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. May have a tumor suppressor role; an ectopic expression suppressing tumor cell growth.

Gene Wiki entry for INTS6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INTS6 Gene

Genomics for INTS6 Gene

Regulatory Elements for INTS6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for INTS6 Gene

Start:
51,354,077 bp from pter
End:
51,454,264 bp from pter
Size:
100,188 bases
Orientation:
Minus strand

Genomic View for INTS6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for INTS6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INTS6 Gene

Proteins for INTS6 Gene

  • Protein details for INTS6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UL03-INT6_HUMAN
    Recommended name:
    Integrator complex subunit 6
    Protein Accession:
    Q9UL03
    Secondary Accessions:
    • Q0P664
    • Q6PJP4
    • Q9UFK0
    • Q9Y5M9

    Protein attributes for INTS6 Gene

    Size:
    887 amino acids
    Molecular mass:
    100390 Da
    Quaternary structure:
    • Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12.
    SequenceCaution:
    • Sequence=AAH13358.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AL833524; Type=Erroneous termination; Positions=796; Note=Translated as Gly.; Evidence={ECO:0000305}; Sequence=CAB56020.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for INTS6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for INTS6 Gene

Proteomics data for INTS6 Gene at MOPED

Post-translational modifications for INTS6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for INTS6 Gene

Domains for INTS6 Gene

Gene Families for INTS6 Gene

HGNC:
  • DDX :DEAD-boxes

Graphical View of Domain Structure for InterPro Entry

Q9UL03

UniProtKB/Swiss-Prot:

INT6_HUMAN :
  • Q9UL03
Domain:
  • Contains 1 VWFA domain.
Family:
  • Belongs to the Integrator subunit 6 family.
genes like me logo Genes that share domains with INTS6: view

Function for INTS6 Gene

Molecular function for INTS6 Gene

UniProtKB/Swiss-Prot Function:
Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. May have a tumor suppressor role; an ectopic expression suppressing tumor cell growth.
UniProtKB/Swiss-Prot Induction:
Frequently down-regulated in nonsmall cell lung carcinomas and prostate cancers. Down-regulation in prostate cancer is due to CpG hypermethylation of its promoter. However, some involvement in cancer is unclear.

Gene Ontology (GO) - Molecular Function for INTS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 10467397
GO:0005515 protein binding IPI 16239144
genes like me logo Genes that share ontologies with INTS6: view
genes like me logo Genes that share phenotypes with INTS6: view

Animal Model Products

miRNA for INTS6 Gene

miRTarBase miRNAs that target INTS6

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for INTS6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for INTS6 Gene

Localization for INTS6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for INTS6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for INTS6 Gene COMPARTMENTS Subcellular localization image for INTS6 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 2

Gene Ontology (GO) - Cellular Components for INTS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0015629 actin cytoskeleton IDA --
GO:0032039 integrator complex IDA 16239144
genes like me logo Genes that share ontologies with INTS6: view

Pathways for INTS6 Gene

SuperPathways for INTS6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for INTS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 10467397
GO:0016180 snRNA processing IDA 16239144
genes like me logo Genes that share ontologies with INTS6: view

No data available for Pathways by source for INTS6 Gene

Compounds for INTS6 Gene

(18) Novoseek inferred chemical compound relationships for INTS6 Gene

Compound -log(P) Hits PubMed IDs
2-methyltetrahydrofuran 73 1
pyridine 63.6 2
fe3+ 57.1 1
toluene 53 1
carboxylate 49.5 1
genes like me logo Genes that share compounds with INTS6: view

Transcripts for INTS6 Gene

Unigene Clusters for INTS6 Gene

Integrator complex subunit 6:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for INTS6

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for INTS6 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13 ^
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3:
SP4: - - - - - - - - - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - - - - -
SP7: - - - - - - - - - - - - - - -
SP8: - - - -
SP9: - - - - - - - - - -
SP10: - -
SP11: - - - - - - -
SP12: - - - - - -
SP13:
SP14:
SP15:
SP16:

ExUns: 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27
SP1: - -
SP2: - -
SP3: - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: -
SP16:

Relevant External Links for INTS6 Gene

GeneLoc Exon Structure for
INTS6
ECgene alternative splicing isoforms for
INTS6

Expression for INTS6 Gene

mRNA expression in normal human tissues for INTS6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for INTS6 Gene

This gene is overexpressed in Testis (10.6), Placenta (10.6), Peripheral blood mononuclear cells (10.3), Pancreas (9.4), and CD8 Tcells (6.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for INTS6 Gene

SOURCE GeneReport for Unigene cluster for INTS6 Gene Hs.439440

mRNA Expression by UniProt/SwissProt for INTS6 Gene

Q9UL03-INT6_HUMAN
Tissue specificity: Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expressions with INTS6: view

Expression partners for INTS6 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for INTS6 Gene

Orthologs for INTS6 Gene

This gene was present in the common ancestor of animals.

Orthologs for INTS6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia INTS6 35
  • 93.94 (n)
  • 97.14 (a)
INTS6 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia INTS6 35
  • 95.64 (n)
  • 97.78 (a)
INTS6 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ints6 35
  • 92.68 (n)
  • 96.38 (a)
Ints6 16
Ints6 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia INTS6 35
  • 98.65 (n)
  • 98.18 (a)
INTS6 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ints6 35
  • 92.11 (n)
  • 96.26 (a)
oppossum
(Monodelphis domestica)
Mammalia INTS6 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia INTS6 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves INTS6 35
  • 82.39 (n)
  • 86.09 (a)
INTS6 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10794 35
zebrafish
(Danio rerio)
Actinopterygii Dr.11487 35
ints6 35
  • 67.31 (n)
  • 73.16 (a)
ints6 36
  • 68 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000631 35
  • 48.89 (n)
  • 46.53 (a)
fruit fly
(Drosophila melanogaster)
Insecta IntS6 36
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dic-1 36
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToMany
Species with no ortholog for INTS6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for INTS6 Gene

ENSEMBL:
Gene Tree for INTS6 (if available)
TreeFam:
Gene Tree for INTS6 (if available)

Paralogs for INTS6 Gene

Paralogs for INTS6 Gene

Pseudogenes.org Pseudogenes for INTS6 Gene

genes like me logo Genes that share paralogs with INTS6: view

Variants for INTS6 Gene

Sequence variations from dbSNP and Humsavar for INTS6 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs944869 -- 51,429,125(-) ATCTA(C/G)TTTCT intron-variant
rs1062150 -- 51,407,044(-) AACTG(A/G)AAGAA intron-variant
rs1413103 -- 51,425,945(-) ACTGG(G/T)TGTAG intron-variant
rs1547710 -- 51,427,849(-) CAGAG(A/T)TTTTA intron-variant
rs1970132 -- 51,428,608(-) ggtgg(C/T)tcaca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for INTS6 Gene

Variant ID Type Subtype PubMed ID
nsv832611 CNV Loss 17160897

Relevant External Links for INTS6 Gene

HapMap Linkage Disequilibrium report
INTS6
Human Gene Mutation Database (HGMD)
INTS6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INTS6 Gene

Disorders for INTS6 Gene

(8) Novoseek inferred disease relationships for INTS6 Gene

Disease -log(P) Hits PubMed IDs
carcinoma non-small cell lung 28.8 4
endometrial carcinoma 26.6 1
allelic loss 26 1
retinoblastoma 6.57 1
tumors 0 6
genes like me logo Genes that share disorders with INTS6: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Genatlas and External Links for INTS6 Gene

Publications for INTS6 Gene

  1. Isolation of DICE1: a gene frequently affected by LOH and downregulated in lung carcinomas. (PMID: 10467397) Wieland I. … Weidle U.H. (Oncogene 1999) 2 3 4 23
  2. Promoter CpG hypermethylation and downregulation of DICE1 expression in prostate cancer. (PMID: 16007164) Roepke A. … Wieacker P.F. (Oncogene 2005) 3 4 23
  3. Ectopic expression of DICE1 suppresses tumor cell growth. (PMID: 15254679) Wieland I. … Wieacker P. (Oncol. Rep. 2004) 3 4 23
  4. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PMID: 16239144) Baillat D. … Shiekhattar R. (Cell 2005) 2 3 4
  5. Absence of mutations in DICE1/DDX26 gene in human cancer cell lines with frequent 13q14 deletions. (PMID: 16271964) Hernandez M. … Almeida T.A. (Cancer Genet. Cytogenet. 2005) 3 4

Products for INTS6 Gene

Sources for INTS6 Gene

Back to Top

Content