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Aliases for INTS5 Gene

Aliases for INTS5 Gene

  • Integrator Complex Subunit 5 2 3 5
  • KIAA1698 2 3 4
  • INT5 3 4

External Ids for INTS5 Gene

Previous HGNC Symbols for INTS5 Gene

  • KIAA1698

Previous GeneCards Identifiers for INTS5 Gene

  • GC11M062172
  • GC11M062431
  • GC11M058743
  • GC11M062484
  • GC11M062678
  • GC11M062700
  • GC11M062722
  • GC11M062734
  • GC11M062746
  • GC11M062765

Summaries for INTS5 Gene

Entrez Gene Summary for INTS5 Gene

  • The Integrator complex is a complex that associates with the C-terminal domain of RNA polymerase II large subunit. This complex is brought to U1 and U2 small nuclear RNA genes, where it is involved in the transcription and processing of their transcripts. The protein encoded by this gene represents a subunit of the Integrator complex. [provided by RefSeq, Aug 2016]

GeneCards Summary for INTS5 Gene

INTS5 (Integrator Complex Subunit 5) is a Protein Coding gene. Diseases associated with INTS5 include Leigh Syndrome. Among its related pathways are RNA polymerase II transcribes snRNA genes and Gene Expression.

UniProtKB/Swiss-Prot for INTS5 Gene

  • Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).

Additional gene information for INTS5 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INTS5 Gene

Genomics for INTS5 Gene

Regulatory Elements for INTS5 Gene

Enhancers for INTS5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H062838 1.5 ENCODE dbSUPER 66.1 -187.5 -187544 4 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 ZC3H11A NFYC UBXN1 METTL12 WDR74 NXF1 SNHG1 INTS5 LOC105369332 STX5 MTA2 GANAB
GH11H062852 1.7 FANTOM5 ENCODE dbSUPER 48.7 -202.5 -202536 5 HNRNPUL1 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 SNHG1 METTL12 NXF1 MTA2 GANAB INTS5 UBXN1 EML3 STX5 LOC105369332
GH11H061960 1.8 FANTOM5 ENCODE dbSUPER 42.3 +684.4 684379 16 MLX ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D UBXN1 LOC105369332 WDR74 INTS5 MTA2 CPSF7 TMEM138 NXF1 EML3 STX5
GH11H062041 1.4 ENCODE dbSUPER 51.8 +607.9 607875 8 PKNOX1 ARNT ZFP64 FEZF1 ZNF766 FOS SP3 ZC3H11A REST SREBF1 METTL12 CPSF7 SNHG1 GANAB LOC105369332 NXF1 TMEM138 TUT1 INTS5 MTA2
GH11H062669 1.1 ENCODE 52 -18.2 -18187 4 HNRNPUL1 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF766 EML3 WDR74 LOC105369332 GANAB MTA2 STX5 INTS5 METTL12 NXF1 SNHG1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around INTS5 on UCSC Golden Path with GeneCards custom track

Promoters for INTS5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000040456 102 1601 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for INTS5 Gene

Chromosome:
11
Start:
62,646,848 bp from pter
End:
62,653,302 bp from pter
Size:
6,455 bases
Orientation:
Minus strand

Genomic View for INTS5 Gene

Genes around INTS5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INTS5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INTS5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INTS5 Gene

Proteins for INTS5 Gene

  • Protein details for INTS5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P9B9-INT5_HUMAN
    Recommended name:
    Integrator complex subunit 5
    Protein Accession:
    Q6P9B9
    Secondary Accessions:
    • Q8N6W5
    • Q9C0G5

    Protein attributes for INTS5 Gene

    Size:
    1019 amino acids
    Molecular mass:
    107995 Da
    Quaternary structure:
    • Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.
    SequenceCaution:
    • Sequence=AAH28025.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for INTS5 Gene

Post-translational modifications for INTS5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for INTS5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for INTS5 Gene

Domains & Families for INTS5 Gene

Gene Families for INTS5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for INTS5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for INTS5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P9B9

UniProtKB/Swiss-Prot:

INT5_HUMAN :
  • Belongs to the Integrator subunit 5 family.
Family:
  • Belongs to the Integrator subunit 5 family.
genes like me logo Genes that share domains with INTS5: view

Function for INTS5 Gene

Molecular function for INTS5 Gene

UniProtKB/Swiss-Prot Function:
Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).

Phenotypes From GWAS Catalog for INTS5 Gene

Gene Ontology (GO) - Molecular Function for INTS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16239144
genes like me logo Genes that share ontologies with INTS5: view
genes like me logo Genes that share phenotypes with INTS5: view

Animal Model Products

CRISPR Products

miRNA for INTS5 Gene

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for INTS5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for INTS5 Gene

Localization for INTS5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for INTS5 Gene

Nucleus membrane; Multi-pass membrane protein. Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for INTS5 gene
Compartment Confidence
nucleus 5
plasma membrane 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for INTS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 23904267
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA,IEA 23904267
GO:0016020 membrane IEA,IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with INTS5: view

Pathways & Interactions for INTS5 Gene

genes like me logo Genes that share pathways with INTS5: view

Pathways by source for INTS5 Gene

2 Reactome pathways for INTS5 Gene

Gene Ontology (GO) - Biological Process for INTS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016180 snRNA processing IDA 16239144
GO:0042795 snRNA transcription from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with INTS5: view

No data available for SIGNOR curated interactions for INTS5 Gene

Drugs & Compounds for INTS5 Gene

(8) Drugs for INTS5 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(23) Additional Compounds for INTS5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with INTS5: view

Transcripts for INTS5 Gene

mRNA/cDNA for INTS5 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(318) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for INTS5 Gene

Integrator complex subunit 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for INTS5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for INTS5 Gene

No ASD Table

Relevant External Links for INTS5 Gene

GeneLoc Exon Structure for
INTS5
ECgene alternative splicing isoforms for
INTS5

Expression for INTS5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for INTS5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for INTS5 Gene

This gene is overexpressed in CD8 Tcells (13.0), Fetal gut (11.5), Placenta (10.9), and Lymph node (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for INTS5 Gene



Protein tissue co-expression partners for INTS5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of INTS5 Gene:

INTS5

SOURCE GeneReport for Unigene cluster for INTS5 Gene:

Hs.458390

Evidence on tissue expression from TISSUES for INTS5 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with INTS5: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for INTS5 Gene

Orthologs for INTS5 Gene

This gene was present in the common ancestor of animals.

Orthologs for INTS5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INTS5 33 34
  • 99.71 (n)
cow
(Bos Taurus)
Mammalia KIAA1698 34
  • 97 (a)
OneToOne
INTS5 33
  • 90.01 (n)
dog
(Canis familiaris)
Mammalia INTS5 33 34
  • 91.27 (n)
rat
(Rattus norvegicus)
Mammalia Ints5 33
  • 88.58 (n)
mouse
(Mus musculus)
Mammalia Ints5 33 16 34
  • 88.47 (n)
oppossum
(Monodelphis domestica)
Mammalia INTS5 34
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC101750875 33
  • 64.33 (n)
lizard
(Anolis carolinensis)
Reptilia INTS5 34
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ints5 33
  • 59.04 (n)
Str.9132 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.1656 33
zebrafish
(Danio rerio)
Actinopterygii LOC564642 33
  • 57.35 (n)
INTS5 (2 of 2) 34
  • 54 (a)
OneToMany
INTS5 (1 of 2) 34
  • 53 (a)
OneToMany
Dr.17427 33
fruit fly
(Drosophila melanogaster)
Insecta omd 34
  • 23 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 26 (a)
OneToOne
Species where no ortholog for INTS5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for INTS5 Gene

ENSEMBL:
Gene Tree for INTS5 (if available)
TreeFam:
Gene Tree for INTS5 (if available)

Paralogs for INTS5 Gene

No data available for Paralogs for INTS5 Gene

Variants for INTS5 Gene

Sequence variations from dbSNP and Humsavar for INTS5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000024694 -- 62,653,844(+) AGAGA(A/G)AGAGA upstream-variant-2KB
rs1000067995 -- 62,651,445(+) AGTAA(-/T)TAATA intron-variant
rs1000121409 -- 62,651,128(+) CGCCC(C/G)GAGAG intron-variant
rs1000824171 -- 62,649,076(+) TGGCC(A/T)GAAGG reference, missense
rs1001084191 -- 62,649,782(+) AGGTG(A/G)ACCAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for INTS5 Gene

Variant ID Type Subtype PubMed ID
nsv555174 CNV gain 21841781
nsv832182 CNV gain+loss 17160897

Variation tolerance for INTS5 Gene

Residual Variation Intolerance Score: 2.25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.07; 37.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for INTS5 Gene

Human Gene Mutation Database (HGMD)
INTS5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
INTS5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INTS5 Gene

Disorders for INTS5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for INTS5 Gene - From: GeneCards

Disorder Aliases PubMed IDs
leigh syndrome
  • leigh syndrome due to mitochondrial complex i deficiency
- elite association - COSMIC cancer census association via MalaCards
Search INTS5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for INTS5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
INTS5
genes like me logo Genes that share disorders with INTS5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for INTS5 Gene

Publications for INTS5 Gene

  1. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PMID: 16239144) Baillat D … Shiekhattar R (Cell 2005) 2 3 4 60
  2. Nuclear-localized Asunder regulates cytoplasmic dynein localization via its role in the integrator complex. (PMID: 23904267) Jodoin JN … Lee LA (Molecular biology of the cell 2013) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for INTS5 Gene

Sources for INTS5 Gene

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