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Aliases for INTS5 Gene

Aliases for INTS5 Gene

  • Integrator Complex Subunit 5 2 3 5
  • KIAA1698 2 3 4
  • INT5 3 4

External Ids for INTS5 Gene

Previous HGNC Symbols for INTS5 Gene

  • KIAA1698

Previous GeneCards Identifiers for INTS5 Gene

  • GC11M062172
  • GC11M062431
  • GC11M058743
  • GC11M062484
  • GC11M062678
  • GC11M062700

Summaries for INTS5 Gene

Entrez Gene Summary for INTS5 Gene

  • INTS5 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]

GeneCards Summary for INTS5 Gene

INTS5 (Integrator Complex Subunit 5) is a Protein Coding gene. Diseases associated with INTS5 include leigh syndrome. Among its related pathways are Gene Expression and RNA Polymerase II Transcription Initiation And Promoter Clearance.

UniProtKB/Swiss-Prot for INTS5 Gene

  • Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INTS5 Gene

Genomics for INTS5 Gene

Regulatory Elements for INTS5 Gene

Promoters for INTS5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around INTS5 on UCSC Golden Path with GeneCards custom track

Genomic Location for INTS5 Gene

Chromosome:
11
Start:
62,646,848 bp from pter
End:
62,653,302 bp from pter
Size:
6,455 bases
Orientation:
Minus strand

Genomic View for INTS5 Gene

Genes around INTS5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INTS5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INTS5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INTS5 Gene

Proteins for INTS5 Gene

  • Protein details for INTS5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P9B9-INT5_HUMAN
    Recommended name:
    Integrator complex subunit 5
    Protein Accession:
    Q6P9B9
    Secondary Accessions:
    • Q8N6W5
    • Q9C0G5

    Protein attributes for INTS5 Gene

    Size:
    1019 amino acids
    Molecular mass:
    107995 Da
    Quaternary structure:
    • Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12.
    SequenceCaution:
    • Sequence=AAH28025.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for INTS5 Gene

Proteomics data for INTS5 Gene at MOPED

Post-translational modifications for INTS5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for INTS5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for INTS5

No data available for DME Specific Peptides for INTS5 Gene

Domains & Families for INTS5 Gene

Protein Domains for INTS5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for INTS5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with INTS5: view

No data available for Gene Families and UniProtKB/Swiss-Prot for INTS5 Gene

Function for INTS5 Gene

Molecular function for INTS5 Gene

UniProtKB/Swiss-Prot Function:
Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.
genes like me logo Genes that share phenotypes with INTS5: view

Animal Model Products

miRNA for INTS5 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for INTS5 Gene

Localization for INTS5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for INTS5 Gene

Nucleus. Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for INTS5 Gene COMPARTMENTS Subcellular localization image for INTS5 gene
Compartment Confidence
nucleus 4
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for INTS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with INTS5: view

Pathways & Interactions for INTS5 Gene

genes like me logo Genes that share pathways with INTS5: view

Pathways by source for INTS5 Gene

2 Reactome pathways for INTS5 Gene

Gene Ontology (GO) - Biological Process for INTS5 Gene

None

No data available for SIGNOR curated interactions for INTS5 Gene

Drugs & Compounds for INTS5 Gene

(6) Drugs for INTS5 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(25) Additional Compounds for INTS5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with INTS5: view

Transcripts for INTS5 Gene

mRNA/cDNA for INTS5 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(318) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for INTS5 Gene

Integrator complex subunit 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for INTS5 Gene

No ASD Table

Relevant External Links for INTS5 Gene

GeneLoc Exon Structure for
INTS5
ECgene alternative splicing isoforms for
INTS5

Expression for INTS5 Gene

mRNA expression in normal human tissues for INTS5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for INTS5 Gene

This gene is overexpressed in CD8 Tcells (13.0), Fetal gut (11.5), Placenta (10.9), and Lymph node (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for INTS5 Gene



SOURCE GeneReport for Unigene cluster for INTS5 Gene Hs.458390

genes like me logo Genes that share expression patterns with INTS5: view

Protein tissue co-expression partners for INTS5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for INTS5 Gene

Orthologs for INTS5 Gene

This gene was present in the common ancestor of animals.

Orthologs for INTS5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INTS5 35
  • 99.71 (n)
  • 99.8 (a)
INTS5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KIAA1698 36
  • 97 (a)
OneToOne
INTS5 35
  • 90.01 (n)
  • 96.76 (a)
dog
(Canis familiaris)
Mammalia INTS5 35
  • 91.27 (n)
  • 97.55 (a)
INTS5 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ints5 36
  • 95 (a)
OneToOne
Ints5 16
Ints5 35
  • 88.47 (n)
  • 95.38 (a)
oppossum
(Monodelphis domestica)
Mammalia INTS5 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ints5 35
  • 88.58 (n)
  • 95.29 (a)
chicken
(Gallus gallus)
Aves LOC101750875 35
  • 64.33 (n)
  • 65.91 (a)
lizard
(Anolis carolinensis)
Reptilia INTS5 36
  • 62 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1656 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ints5 35
  • 59.04 (n)
  • 61.12 (a)
Str.9132 35
zebrafish
(Danio rerio)
Actinopterygii INTS5 (1 of 2) 36
  • 53 (a)
OneToMany
INTS5 (2 of 2) 36
  • 54 (a)
OneToMany
Dr.17427 35
LOC564642 35
  • 57.35 (n)
  • 55.2 (a)
fruit fly
(Drosophila melanogaster)
Insecta omd 36
  • 23 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
OneToOne
Species with no ortholog for INTS5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for INTS5 Gene

ENSEMBL:
Gene Tree for INTS5 (if available)
TreeFam:
Gene Tree for INTS5 (if available)

Paralogs for INTS5 Gene

No data available for Paralogs for INTS5 Gene

Variants for INTS5 Gene

Sequence variations from dbSNP and Humsavar for INTS5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs2510074 -- 62,652,321(-) ttttt(G/T)ttttt intron-variant
rs2958232 -- 62,652,229(+) catga(A/G)aatcg intron-variant
rs9734446 -- 62,651,768(+) ttgag(G/T)cagaa intron-variant
rs11231173 -- 62,651,449(+) AATAA(A/T)ATCAG intron-variant
rs72927273 -- 62,653,875(-) TAAAA(C/T)ACCCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for INTS5 Gene

Variant ID Type Subtype PubMed ID
nsv832182 CNV Gain+Loss 17160897

Variation tolerance for INTS5 Gene

Residual Variation Intolerance Score: 2.25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.07; 37.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for INTS5 Gene

HapMap Linkage Disequilibrium report
INTS5
Human Gene Mutation Database (HGMD)
INTS5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INTS5 Gene

Disorders for INTS5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for INTS5 Gene - From: GeneCards

Disorder Aliases PubMed IDs
leigh syndrome
  • leigh syndrome due to mitochondrial complex i deficiency
- elite association - COSMIC cancer census association via MalaCards
Search INTS5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for INTS5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
INTS5
genes like me logo Genes that share disorders with INTS5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for INTS5 Gene

Publications for INTS5 Gene

  1. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PMID: 16239144) Baillat D. … Shiekhattar R. (Cell 2005) 2 3 4 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. Defining the membrane proteome of NK cells. (PMID: 19946888) Ghosh D. … Wilkins J.A. (J Mass Spectrom 2010) 3

Products for INTS5 Gene

Sources for INTS5 Gene

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