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Aliases for INTS5 Gene

Aliases for INTS5 Gene

  • Integrator Complex Subunit 5 2 3 5
  • KIAA1698 2 3 4
  • INT5 3 4

External Ids for INTS5 Gene

Previous HGNC Symbols for INTS5 Gene

  • KIAA1698

Previous GeneCards Identifiers for INTS5 Gene

  • GC11M062172
  • GC11M062431
  • GC11M058743
  • GC11M062484
  • GC11M062678
  • GC11M062700
  • GC11M062722
  • GC11M062734

Summaries for INTS5 Gene

Entrez Gene Summary for INTS5 Gene

  • The Integrator complex is a complex that associates with the C-terminal domain of RNA polymerase II large subunit. This complex is brought to U1 and U2 small nuclear RNA genes, where it is involved in the transcription and processing of their transcripts. The protein encoded by this gene represents a subunit of the Integrator complex. [provided by RefSeq, Aug 2016]

GeneCards Summary for INTS5 Gene

INTS5 (Integrator Complex Subunit 5) is a Protein Coding gene. Among its related pathways are Gene Expression and Formation of HIV elongation complex in the absence of HIV Tat.

UniProtKB/Swiss-Prot for INTS5 Gene

  • Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INTS5 Gene

Genomics for INTS5 Gene

Regulatory Elements for INTS5 Gene

Enhancers for INTS5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F062041 1.4 Ensembl ENCODE 64.4 +607.9 607875 8.1 MLX CREB3L1 ZFP64 DMAP1 FEZF1 YY1 ZNF143 SP3 NFYC MEF2D METTL12 INTS5 SNHG1 NXF1 TMEM138 LOC105369332 VPS37C EML3 MTA2 TAF6L
GH11F062852 1.3 FANTOM5 ENCODE 37.8 -202.5 -202536 5.9 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC METTL12 INTS5 NXF1 SNHG1 UBXN1 MTA2 EML3 MIR6748 LOC105369332 STX5
GH11F062838 0.2 ENCODE 32.7 -187.5 -187544 4.8 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 METTL12 UBXN1 LRRN4CL NXF1 TAF6L INTS5 IMMP1LP1 SNHG1 TTC9C STX5
GH11F061960 1.2 FANTOM5 ENCODE 32.7 +684.4 684379 16.4 CREB3L1 MLX ZFP64 YBX1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC INTS5 UBXN1 METTL12 NXF1 TTC9C MTA2 TMEM138 EML3 STX5 BEST1
GH11F062651 0.2 ENCODE 30 +0.5 472 2.3 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 EML3 METTL12 INTS5 MTA2 NXF1 STX5 SNHG1 TAF6L LOC105369332 MIR6748
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around INTS5 on UCSC Golden Path with GeneCards custom track

Promoters for INTS5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001052421 202 1801 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for INTS5 Gene

Chromosome:
11
Start:
62,646,848 bp from pter
End:
62,653,302 bp from pter
Size:
6,455 bases
Orientation:
Minus strand

Genomic View for INTS5 Gene

Genes around INTS5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INTS5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INTS5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INTS5 Gene

Proteins for INTS5 Gene

  • Protein details for INTS5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P9B9-INT5_HUMAN
    Recommended name:
    Integrator complex subunit 5
    Protein Accession:
    Q6P9B9
    Secondary Accessions:
    • Q8N6W5
    • Q9C0G5

    Protein attributes for INTS5 Gene

    Size:
    1019 amino acids
    Molecular mass:
    107995 Da
    Quaternary structure:
    • Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12.
    SequenceCaution:
    • Sequence=AAH28025.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for INTS5 Gene

Post-translational modifications for INTS5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for INTS5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for INTS5 Gene

Domains & Families for INTS5 Gene

Gene Families for INTS5 Gene

Protein Domains for INTS5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for INTS5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P9B9

UniProtKB/Swiss-Prot:

INT5_HUMAN :
  • Belongs to the Integrator subunit 5 family.
Family:
  • Belongs to the Integrator subunit 5 family.
genes like me logo Genes that share domains with INTS5: view

Function for INTS5 Gene

Molecular function for INTS5 Gene

UniProtKB/Swiss-Prot Function:
Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.

Gene Ontology (GO) - Molecular Function for INTS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16239144
genes like me logo Genes that share ontologies with INTS5: view
genes like me logo Genes that share phenotypes with INTS5: view

Animal Model Products

miRNA for INTS5 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for INTS5 Gene

Localization for INTS5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for INTS5 Gene

Nucleus membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for INTS5 Gene COMPARTMENTS Subcellular localization image for INTS5 gene
Compartment Confidence
nucleus 4
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for INTS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0016020 membrane IEA,IDA 19946888
GO:0016021 integral component of membrane IEA --
GO:0031965 nuclear membrane IEA --
genes like me logo Genes that share ontologies with INTS5: view

Pathways & Interactions for INTS5 Gene

genes like me logo Genes that share pathways with INTS5: view

Pathways by source for INTS5 Gene

2 Reactome pathways for INTS5 Gene

Gene Ontology (GO) - Biological Process for INTS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016180 snRNA processing IDA 16239144
GO:0042795 snRNA transcription from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with INTS5: view

No data available for SIGNOR curated interactions for INTS5 Gene

Drugs & Compounds for INTS5 Gene

(8) Drugs for INTS5 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(23) Additional Compounds for INTS5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with INTS5: view

Transcripts for INTS5 Gene

mRNA/cDNA for INTS5 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(318) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for INTS5 Gene

Integrator complex subunit 5:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for INTS5 Gene

No ASD Table

Relevant External Links for INTS5 Gene

GeneLoc Exon Structure for
INTS5
ECgene alternative splicing isoforms for
INTS5

Expression for INTS5 Gene

mRNA expression in normal human tissues for INTS5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for INTS5 Gene

This gene is overexpressed in CD8 Tcells (13.0), Fetal gut (11.5), Placenta (10.9), and Lymph node (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for INTS5 Gene



Protein tissue co-expression partners for INTS5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of INTS5 Gene:

INTS5

SOURCE GeneReport for Unigene cluster for INTS5 Gene:

Hs.458390
genes like me logo Genes that share expression patterns with INTS5: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for INTS5 Gene

Orthologs for INTS5 Gene

This gene was present in the common ancestor of animals.

Orthologs for INTS5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INTS5 34 35
  • 99.71 (n)
cow
(Bos Taurus)
Mammalia KIAA1698 35
  • 97 (a)
OneToOne
INTS5 34
  • 90.01 (n)
dog
(Canis familiaris)
Mammalia INTS5 34 35
  • 91.27 (n)
rat
(Rattus norvegicus)
Mammalia Ints5 34
  • 88.58 (n)
mouse
(Mus musculus)
Mammalia Ints5 34 16 35
  • 88.47 (n)
oppossum
(Monodelphis domestica)
Mammalia INTS5 35
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC101750875 34
  • 64.33 (n)
lizard
(Anolis carolinensis)
Reptilia INTS5 35
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ints5 34
  • 59.04 (n)
Str.9132 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.1656 34
zebrafish
(Danio rerio)
Actinopterygii LOC564642 34
  • 57.35 (n)
INTS5 (2 of 2) 35
  • 54 (a)
OneToMany
INTS5 (1 of 2) 35
  • 53 (a)
OneToMany
Dr.17427 34
fruit fly
(Drosophila melanogaster)
Insecta omd 35
  • 23 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 26 (a)
OneToOne
Species where no ortholog for INTS5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for INTS5 Gene

ENSEMBL:
Gene Tree for INTS5 (if available)
TreeFam:
Gene Tree for INTS5 (if available)

Paralogs for INTS5 Gene

No data available for Paralogs for INTS5 Gene

Variants for INTS5 Gene

Sequence variations from dbSNP and Humsavar for INTS5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs111328501 -- 62,653,704(+) GATTG(C/T)AGTGA upstream-variant-2KB
rs111588839 -- 62,646,650(+) CGCGC(A/G)CTCAG downstream-variant-500B, upstream-variant-2KB, utr-variant-5-prime
rs111683552 -- 62,648,273(+) TGAGG(C/T)AGATT upstream-variant-2KB, reference, missense
rs112186006 -- 62,655,255(+) AAAAG(A/G)AAAAC upstream-variant-2KB
rs11231173 -- 62,651,449(+) AATAA(A/T)ATCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for INTS5 Gene

Variant ID Type Subtype PubMed ID
nsv555174 CNV gain 21841781
nsv832182 CNV gain+loss 17160897

Variation tolerance for INTS5 Gene

Residual Variation Intolerance Score: 2.25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.07; 37.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for INTS5 Gene

Human Gene Mutation Database (HGMD)
INTS5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
INTS5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INTS5 Gene

Disorders for INTS5 Gene

Relevant External Links for INTS5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
INTS5

No disorders were found for INTS5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for INTS5 Gene

Publications for INTS5 Gene

  1. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PMID: 16239144) Baillat D. … Shiekhattar R. (Cell 2005) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 3 4 64
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for INTS5 Gene

Sources for INTS5 Gene

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