Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

INTS5 Gene

protein-coding   GIFtS: 46
GCID: GC11M062431

Integrator Complex Subunit 5

(Previous name: KIAA1698)
(Previous symbol: KIAA1698)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Integrator Complex Subunit 51 2
KIAA16981 2 3
INT52
Int53

External Ids:    HGNC: 293521   Entrez Gene: 807892   Ensembl: ENSG000001850857   OMIM: 6113495   UniProtKB: Q6P9B93   

Export aliases for INTS5 gene to outside databases

Previous GC identifers: GC11M062172 GC11M058743


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for INTS5 Gene:
INTS5 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II
large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM
180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 (PubMed 16239144)).(supplied by OMIM, Mar 2008)

GeneCards Summary for INTS5 Gene: 
INTS5 (integrator complex subunit 5) is a protein-coding gene. Diseases associated with INTS5 include sandhoff disease, and tay-sachs disease. GO annotations related to this gene include protein binding.

UniProtKB/Swiss-Prot: INT5_HUMAN, Q6P9B9
Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2
transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal
domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the INTS5 gene promoter:
         TBP   Max1   NF-1   Sp1   AP-4   POU6F1 (c2)   LUN-1   C/EBPalpha   PPAR-alpha   RORalpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidINTS5 promoter sequence
   Search SABiosciences Chromatin IP Primers for INTS5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INTS5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.3   Ensembl cytogenetic band:  11q12.3   HGNC cytogenetic band: 11q12.3

INTS5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INTS5 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M062431:  view genomic region     (about GC identifiers)

Start:
62,414,320 bp from pter      End:
62,420,774 bp from pter
Size:
6,455 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: INT5_HUMAN, Q6P9B9 (See protein sequence)
Recommended Name: Integrator complex subunit 5  
Size: 1019 amino acids; 107995 Da
Subunit: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5,
INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12
Subcellular location: Nucleus. Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=AAH28025.1; Type=Erroneous initiation;
Secondary accessions: Q8N6W5 Q9C0G5

Explore the universe of human proteins at neXtProt for INTS5: NX_Q6P9B9

Explore proteomics data for INTS5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6P9B9

  • INTS5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    INTS5 Protein Expression
    REFSEQ proteins: NP_085131.1  
    ENSEMBL proteins: 
     ENSP00000327889  

    Human Recombinant Protein Products for INTS5: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for INTS5
    OriGene Protein Over-expression Lysate for INTS5
    OriGene MassSpec for INTS5 
    OriGene Custom Protein Services for INTS5
    GenScript Custom Purified and Recombinant Proteins Services for INTS5
    Novus Biologicals INTS5 Protein
    Novus Biologicals INTS5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for INTS5 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--
    GO:0032039integrator complex IDA16239144

    INTS5 for ontologies           About GeneDecksing



    INTS5 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for INTS5
    GenScript Custom Superior Antibodies Services for INTS5
    Novus Biologicals INTS5 Antibody
    Abcam antibodies for INTS5
    Cloud-Clone Corp. Antibodies for INTS5 
    ThermoFisher Antibodies for INTS5
    LSBio Antibodies in human, mouse, rat for INTS5 

    Assay Products for INTS5: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for INTS5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for INTS5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for INTS5 
    Cloud-Clone Corp. CLIAs for INTS5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q6P9B9


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: INT5_HUMAN, Q6P9B9
    Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2
    transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal
    domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16239144
         
    INTS5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for INTS5:
     Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for INTS5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for INTS5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for INTS5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for INTS5 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat INTS5
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate INTS5:
    hsa-miR-548t hsa-miR-542-3p hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidINTS5 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for INTS5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat INTS5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for INTS5
    Sirion Biotech Customized adenovirus for overexpression of INTS5

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for INTS5 (see all 7)
    OriGene ORF clones in mouse, rat for INTS5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: INTS5 (NM_030628)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INTS5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INTS5
    Sirion Biotech Customized lentivirus for stable overexpression of INTS5 
                         Customized lentivirus expression plasmids for stable overexpression of INTS5 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for INTS5
    Search LifeMap BioReagents cell lines for INTS5
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTS5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for INTS5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/38 Interacting proteins for INTS5 (Q6P9B93 ENSP000003278894) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    INTS10Q9NVR23, ENSP000003810644I2D: score=1 STRING: ENSP00000381064
    INTS2Q9H0H03, ENSP000004142374I2D: score=1 STRING: ENSP00000414237
    INTS8Q75QN23, ENSP000003432744I2D: score=1 STRING: ENSP00000343274
    INTS9Q9NV883, ENSP000003982084I2D: score=1 STRING: ENSP00000398208
    NABP1Q96AH03, ENSP000004036834I2D: score=1 STRING: ENSP00000403683
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016180snRNA processing IDA16239144

    INTS5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    INTS5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for INTS5 (INT5)

    10/31 Novoseek inferred chemical compound relationships for INTS5 gene (see all 31)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pyridine 64.7 2 12206686 (1), 20023986 (1)
    hydride 54.9 1 11209602 (1)
    acetonitrile 51.5 5 15558123 (1), 15106989 (1), 16296864 (1), 15907139 (1)
    platinum 49.9 2 18816563 (1)
    carboxylate 48.6 2 16999412 (1)
    methylene 45 2 12794902 (1), 19053350 (1)
    oxo 44.7 1 16999412 (1)
    bromide 42.5 2 15356752 (1), 12971786 (1)
    chromium(iii) 41.4 1 17371015 (1)
    cyanide 39.8 3 15356752 (1), 17375912 (1)

    Search CenterWatch for drugs/clinical trials and news about INTS5 / INT5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for INTS5 gene: 
    NM_030628.1  

    Unigene Cluster for INTS5:

    Integrator complex subunit 5
    Hs.458390  [show with all ESTs]
    Unigene Representative Sequence: BC060841
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000330574(uc001nud.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat INTS5
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate INTS5:
    hsa-miR-548t hsa-miR-542-3p hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidINTS5 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for INTS5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat INTS5
    Clone
    Products:
         
    OriGene clones in human, mouse for INTS5 (see all 7)
    OriGene ORF clones in mouse, rat for INTS5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: INTS5 (NM_030628)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INTS5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INTS5
    Sirion Biotech Customized lentivirus for stable overexpression of INTS5 
                         Customized lentivirus expression plasmids for stable overexpression of INTS5 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for INTS5
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat INTS5
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INTS5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INTS5

    Additional mRNA sequence: 

    AB051485.1 AK074261.1 AK123587.1 BC028025.1 BC060841.1 

    8 DOTS entries:

    DT.99961798  DT.212683  DT.100710600  DT.100731848  DT.100834410  DT.120710040  DT.86847498  DT.100776083 

    24/318 AceView cDNA sequences (see all 318):

    AA774707 BQ708359 AI088274 BM716337 AB051485 BX107288 AA451751 F37288 
    BM803904 AI683996 AA729799 BM707514 NM_030628 BQ233665 NM_024099 BE280823 
    BC060841 CA454134 AA598415 BU552979 AI811165 AI802787 CR623757 BC000271 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    INTS5 expression in normal human tissues (normalized intensities)      INTS5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCCCTTGCC
    INTS5 Expression
    About this image


    INTS5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles

    See INTS5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for INTS5

    SOURCE GeneReport for Unigene cluster: Hs.458390
        SABiosciences Custom PCR Arrays for INTS5
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for INTS5
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat INTS5
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INTS5
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INTS5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTS5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for INTS5 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ints51 , 5 integrator complex subunit 51, 5 88.74(n)1
    95.48(a)1
      19 (5.95 cM)5
    1090771  NM_176843.31  NP_789813.11 
     88929875 
    lizard
    (Anolis carolinensis)
    Reptilia INTS56
    Uncharacterized protein
    62(a)
    1 ↔ 1
    AAWZ02040098(2551-5379)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.16562 Xenopus laevis transcribed sequences 74.3(n)    CF286495.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.174272 Transcribed sequences 71.65(n)    BM889916.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta omd6
    oocyte maintenance defects
    22(a)
    1 ↔ 1
    3R(9505151-9512932)
    worm
    (Caenorhabditis elegans)
    Secernentea Y51A2D.76
    Protein Y51A2D.7, isoform b
    14(a)
    1 ↔ 1
    V(18533963-18549104)


    ENSEMBL Gene Tree for INTS5 (if available)
    TreeFam Gene Tree for INTS5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/122 SNPs in INTS5 are shown (see all 122)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1405310771,2
    C,F--62416228(+) CAGCAG/ACAGCT 2 /L syn11Minor allele frequency- A:0.00NA 4544
    rs2019984961,2
    --62416526(+) AGCTGA/CAGTAG 2 L syn10--------
    rs1433227691,2
    C--62416621(+) CTCCCA/GTCGGA 2 R W mis10--------
    rs1449714641,2
    C--62416641(+) CGTGGC/GGGGAG 2 P R mis11Minor allele frequency- G:0.00NA 4514
    rs1879403181,2
    C--62416751(+) TGAGAA/GGAGCT 2 S syn10--------
    rs1179918651,2
    C,F--62416859(+) GAGGAG/ACCAAT 2 /G syn13Minor allele frequency- A:0.01NA EU 5965
    rs2014404511,2
    --62416931(+) ACACAA/CGCATC 2 A syn10--------
    rs2002975461,2
    --62416936(+) CGCATC/GTGGGC 2 H D mis10--------
    rs37509891,2
    C,F,H--62417045(+) CCAGTA/TGCGTG 2 A syn1 ese39Minor allele frequency- T:0.01NS EA NA 5504
    rs1389167981,2
    C,F--62417215(+) ACCAGC/GAGGGA 2 P A mis12Minor allele frequency- G:0.00NA EU 5619

    HapMap Linkage Disequilibrium report for INTS5 (62414320 - 62420774 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for INTS5:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv832182CNV Gain+Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing INTS5
    DNA2.0 Custom Variant and Variant Library Synthesis for INTS5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611349    OMIM disorders: --

    11 diseases for INTS5:    About MalaCards
    sandhoff disease    tay-sachs disease    stem cell leukemia    beta thalassemia
    thalassemia    acute myocardial infarction    myocardial infarction    t-cell leukemia
    ovarian cancer    leukemia    prostatitis


    INTS5 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for INTS5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    congestion 6.18 1 16180887 (1)
    epilepsy 0 2 1320496 (1), 8748865 (1)
    ovarian cancer 0 2 16256352 (1), 19926362 (1)


    Export disorders for INTS5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for INTS5 gene, integrated from 9 sources (see all 130):
    (articles sorted by number of sources associating them with INTS5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PubMed id 16239144)1, 2, 3 Baillat D....Shiekhattar R. (2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2 Nagase T.... Ohara O. (2000)
    4. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
    5. Streamlined analysis schema for high-throughput ident ification of endogenous protein complexes. (PubMed id 20133760)1 Malovannaya A....Qin J. (2010)
    6. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
    7. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    9. Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)1 Beausoleil S.A....Gygi S.P. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80789 HGNC: 29352 AceView: MGC2477andKIAA1698 Ensembl:ENSG00000185085 euGenes: HUgn80789
    ECgene: INTS5 H-InvDB: INTS5

    (According to HUGE)
    About This Section
    HUGE: KIAA1698

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for INTS5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for INTS5 gene:
    Search GeneIP for patents involving INTS5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for INTS5  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for INTS5  
     OriGene MassSpec something-or-other for INTS5   OriGene clones in human, mouse for INTS5  
     OriGene qSTAR qPCR primer pairs in human, mouse for INTS5   OriGene Purified Protein for INTS5  
     OriGene ORF clones in mouse, rat for INTS5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for INTS5   OriGene Custom Protein Services for INTS5  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat INTS5
     QIAGEN SeqTarget long-range PCR primers for resequencing INTS5
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INTS5
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat INTS5
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INTS5
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INTS5
     GenScript Custom Purified and Recombinant Proteins Services for INTS5 GenScript cDNA clones with any tag delivered in your preferred vector for INTS5
     GenScript Custom Assay Services for INTS5 GenScript Custom Superior Antibodies Services for INTS5
     GenScript Custom overexpressing Cell Line Services for INTS5 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in INTS5 promoter
     Search Chromatin IP Primers for INTS5
     RT2 qPCR Primer Assay in human, mouse, rat INTS5
     Search GNC Networks for INTS5
     SABiosciences Custom PCR Arrays for INTS5
     Search Tocris compounds for INTS5 (INT5)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     INTS5 antibodies
     INTS5 proteins
     INTS5 lysates
     Antibodies for INTS5
     See all of Abcam's Antibodies, Kits and Proteins for INTS5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for INTS5
     Antibodies for INTS5
     ELISAs for INTS5
     CLIAs for INTS5
     Search LifeMap BioReagents cell lines for INTS5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTS5
     SwitchGear 3'UTR luciferase reporter plasmids for INTS5
     SwitchGear Promoter luciferase reporter plasmids for INTS5
     ThermoFisher Antibodies for INTS5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INTS5
     inGenious Targeting Laboratory - Custom generated mouse model solutions for INTS5
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for INTS5
    Customized:
     lentivirus for stable overexpression of INTS5
     lentivirus expression plasmids for stable overexpression of INTS5
     adenovirus for overexpression of INTS5
     LSBio Antibodies in human, mouse, rat for INTS5
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      INTS5 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4