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INTS5 Gene

protein-coding   GIFtS: 48
GCID: GC11M062484

Integrator Complex Subunit 5

(Previous name: KIAA1698)
(Previous symbol: KIAA1698)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Integrator Complex Subunit 51 2
KIAA16981 2 3 5
INT52 5
Int53

External Ids:    HGNC: 293521   Entrez Gene: 807892   Ensembl: ENSG000001850857   OMIM: 6113495   UniProtKB: Q6P9B93   

Export aliases for INTS5 gene to outside databases

Previous GC identifers: GC11M062172 GC11M062431 GC11M058743


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for INTS5 Gene:
INTS5 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II
large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM
180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 (PubMed 16239144)).(supplied by OMIM, Mar 2008)

GeneCards Summary for INTS5 Gene:
INTS5 (integrator complex subunit 5) is a protein-coding gene. Diseases associated with INTS5 include sandhoff disease, and tay-sachs disease.

UniProtKB/Swiss-Prot: INT5_HUMAN, Q6P9B9
Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2
transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal
domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the INTS5 gene promoter:
         TBP   Max1   NF-1   Sp1   AP-4   POU6F1 (c2)   LUN-1   C/EBPalpha   PPAR-alpha   RORalpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidINTS5 promoter sequence
   Search Chromatin IP Primers for INTS5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat INTS5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.3   Ensembl cytogenetic band:  11q12.3   HGNC cytogenetic band: 11q12.3

INTS5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INTS5 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M062484:  view genomic region     (about GC identifiers)

Start:
62,414,320 bp from pter      End:
62,420,774 bp from pter
Size:
6,455 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: INT5_HUMAN, Q6P9B9 (See protein sequence)
Recommended Name: Integrator complex subunit 5  
Size: 1019 amino acids; 107995 Da
Subunit: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5,
INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12
Sequence caution: Sequence=AAH28025.1; Type=Erroneous initiation;
Secondary accessions: Q8N6W5 Q9C0G5

Explore the universe of human proteins at neXtProt for INTS5: NX_Q6P9B9

Explore proteomics data for INTS5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See INTS5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_085131.1  
    ENSEMBL proteins: 
     ENSP00000327889  

    INTS5 Human Recombinant Protein Products:

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    Novus Biologicals INTS5 Protein
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for INTS5

    INTS5 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for INTS5
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    LSBio Antibodies in human, mouse, rat for INTS5

    INTS5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for INTS5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for INTS5
    Cloud-Clone Corp. CLIAs for INTS5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q6P9B9


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: INT5_HUMAN, Q6P9B9
    Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2
    transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal
    domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16239144
         
    INTS5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for INTS5:
     Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for INTS5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for INTS5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for INTS5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for INTS5

    miRNA
    Products:
        
    miRTarBase miRNAs that target INTS5:
    hsa-let-7b-5p (MIRT032221), hsa-mir-484 (MIRT042227), hsa-mir-193b-3p (MIRT041343), hsa-mir-16-5p (MIRT031398)

    Block miRNA regulation of human, mouse, rat INTS5 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate INTS5:
    hsa-miR-548t hsa-miR-542-3p hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidINTS5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for INTS5
    Predesigned siRNA for gene silencing in human, mouse, rat INTS5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for INTS5

    Clone
    Products:
         
    OriGene clones in human, mouse for INTS5 (see all 6)
    OriGene ORF clones in mouse, rat for INTS5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: INTS5 (NM_030628)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INTS5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INTS5

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for INTS5
    Browse ESI BIO Cell Lines and PureStem Progenitors for INTS5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTS5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    INT5_HUMAN, Q6P9B9: Nucleus. Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--
    GO:0032039integrator complex IDA16239144

    INTS5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for INTS5
    Interactions:

        Search GeneGlobe Interaction Network for INTS5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for INTS5 (Q6P9B93 ENSP000003278894) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    INTS10Q9NVR23, ENSP000003810644I2D: score=1 STRING: ENSP00000381064
    INTS2Q9H0H03, ENSP000004142374I2D: score=1 STRING: ENSP00000414237
    INTS8Q75QN23, ENSP000003432744I2D: score=1 STRING: ENSP00000343274
    INTS9Q9NV883, ENSP000003982084I2D: score=1 STRING: ENSP00000398208
    NABP1Q96AH03, ENSP000004036834I2D: score=1 STRING: ENSP00000403683
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016180snRNA processing IDA16239144

    INTS5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for INTS5 (INT5)

    Selected Novoseek inferred chemical compound relationships for INTS5 gene (see all 31)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pyridine 64.7 2 12206686 (1), 20023986 (1)
    hydride 54.9 1 11209602 (1)
    acetonitrile 51.5 5 15558123 (1), 15106989 (1), 16296864 (1), 15907139 (1)
    platinum 49.9 2 18816563 (1)
    carboxylate 48.6 2 16999412 (1)
    methylene 45 2 12794902 (1), 19053350 (1)
    oxo 44.7 1 16999412 (1)
    bromide 42.5 2 15356752 (1), 12971786 (1)
    chromium(iii) 41.4 1 17371015 (1)
    cyanide 39.8 3 15356752 (1), 17375912 (1)



    INTS5 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for INTS5 gene: 
    NM_030628.1  

    Unigene Cluster for INTS5:

    Integrator complex subunit 5
    Hs.458390  [show with all ESTs]
    Unigene Representative Sequence: BC060841
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000330574(uc001nud.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat INTS5 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate INTS5:
    hsa-miR-548t hsa-miR-542-3p hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidINTS5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for INTS5
    Predesigned siRNA for gene silencing in human, mouse, rat INTS5
    Clone
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    OriGene clones in human, mouse for INTS5 (see all 6)
    OriGene ORF clones in mouse, rat for INTS5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: INTS5 (NM_030628)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INTS5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INTS5
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for INTS5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat INTS5
      QuantiTect SYBR Green Assays in human, mouse, rat INTS5
      QuantiFast Probe-based Assays in human, mouse, rat INTS5

    Additional mRNA sequence: 

    AB051485.1 AK074261.1 AK123587.1 BC028025.1 BC060841.1 

    8 DOTS entries:

    DT.99961798  DT.212683  DT.100710600  DT.100731848  DT.100834410  DT.120710040  DT.86847498  DT.100776083 

    Selected AceView cDNA sequences (see all 318):

    AA877970 AA729799 BC060841 AA451751 AA148434 BG481058 CR623757 AB051485 
    F37288 BX107288 AA257062 CA454134 AI683996 AW295294 BM710491 BX384138 
    BM670731 AI493877 BG288112 BQ277735 AA774707 AA598415 AA112415 BM803904 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    INTS5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCCCTTGCC
    INTS5 Expression
    About this image


    INTS5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
    INTS5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    INTS5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.458390
        Custom PCR Arrays for INTS5
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for INTS5
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTS5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for INTS5 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ints51 , 5 integrator complex subunit 51, 5 88.47(n)1
    95.38(a)1
      19 (5.95 cM)5
    1090771  NM_176843.31  NP_789813.11 
     88929875 
    chicken
    (Gallus gallus)
    Aves LOC1017508751 integrator complex subunit 5-like 64.33(n)
    65.91(a)
      101750875  XM_004950463.1  XP_004950520.1 
    lizard
    (Anolis carolinensis)
    Reptilia INTS56
    integrator complex subunit 5
    62(a)
    1 ↔ 1
    AAWZ02040098(2551-5379)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.16562 Xenopus laevis transcribed sequences 74.3(n)    CF286495.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.174272 Transcribed sequences 71.65(n)    BM889916.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta omd6
    oocyte maintenance defects
    23(a)
    1 ↔ 1
    3R(9505151-9512932)


    ENSEMBL Gene Tree for INTS5 (if available)
    TreeFam Gene Tree for INTS5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for INTS5 (see all 122)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1405310771,2
    C,F--62416228(+) CAGCAG/ACAGCT 2 /L syn11Minor allele frequency- A:0.00NA 4544
    rs2019984961,2
    --62416526(+) AGCTGA/CAGTAG 2 L syn10--------
    rs1433227691,2
    C--62416621(+) CTCCCA/GTCGGA 2 R W mis10--------
    rs1449714641,2
    C--62416641(+) CGTGGC/GGGGAG 2 P R mis11Minor allele frequency- G:0.00NA 4514
    rs1879403181,2
    C--62416751(+) TGAGAA/GGAGCT 2 S syn10--------
    rs1179918651,2
    C,F--62416859(+) GAGGAG/ACCAAT 2 /G syn13Minor allele frequency- A:0.01NA EU 5965
    rs2014404511,2
    --62416931(+) ACACAA/CGCATC 2 A syn10--------
    rs2002975461,2
    --62416936(+) CGCATC/GTGGGC 2 H D mis10--------
    rs37509891,2
    C,F,H--62417045(+) CCAGTA/TGCGTG 2 A syn1 ese39Minor allele frequency- T:0.01NS EA NA 5504
    rs1389167981,2
    C,F--62417215(+) ACCAGC/GAGGGA 2 P A mis12Minor allele frequency- G:0.00NA EU 5619

    HapMap Linkage Disequilibrium report for INTS5 (62414320 - 62420774 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for INTS5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832182CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing INTS5
    DNA2.0 Custom Variant and Variant Library Synthesis for INTS5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611349    OMIM disorders: --

    10 diseases for INTS5:    
    About MalaCards
    sandhoff disease    tay-sachs disease    beta thalassemia    thalassemia
    acute myocardial infarction    ovarian cancer    myocardial infarction    t-cell leukemia
    leukemia    prostatitis


    INTS5 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for INTS5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    congestion 6.18 1 16180887 (1)
    epilepsy 0 2 1320496 (1), 8748865 (1)
    ovarian cancer 0 2 16256352 (1), 19926362 (1)


    Export disorders for INTS5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for INTS5 gene, integrated from 10 sources (see all 131):
    (articles sorted by number of sources associating them with INTS5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PubMed id 16239144)1, 2, 3 Baillat D....Shiekhattar R. (Cell 2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    4. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    5. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)
    6. Streamlined analysis schema for high-throughput identification of endogenous protein complexes. (PubMed id 20133760)1 Malovannaya A....Qin J. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    7. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)
    8. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (Mol. Cell 2008)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)1 Beausoleil S.A.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80789 HGNC: 29352 AceView: MGC2477andKIAA1698 Ensembl:ENSG00000185085 euGenes: HUgn80789
    ECgene: INTS5 H-InvDB: INTS5

    (According to HUGE)
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    HUGE: KIAA1698

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for INTS5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for INTS5 gene:
    Search GeneIP for patents involving INTS5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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