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Aliases for INTS5 Gene

Aliases for INTS5 Gene

  • Integrator Complex Subunit 5 2 3
  • KIAA1698 2 3 4 6
  • INT5 3 4 6

External Ids for INTS5 Gene

Previous Symbols for INTS5 Gene

  • KIAA1698

Summaries for INTS5 Gene

Entrez Gene Summary for INTS5 Gene

  • INTS5 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]

GeneCards Summary for INTS5 Gene

INTS5 (Integrator Complex Subunit 5) is a Protein Coding gene.

UniProtKB/Swiss-Prot for INTS5 Gene

  • Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INTS5 Gene

Genomics for INTS5 Gene

Genomic Location for INTS5 Gene

Start:
62,646,848 bp from pter
End:
62,653,302 bp from pter
Size:
6,455 bases
Orientation:
Minus strand

Genomic View for INTS5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for INTS5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INTS5 Gene

Regulatory Elements for INTS5 Gene

Proteins for INTS5 Gene

  • Protein details for INTS5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P9B9-INT5_HUMAN
    Recommended name:
    Integrator complex subunit 5
    Protein Accession:
    Q6P9B9
    Secondary Accessions:
    • Q8N6W5
    • Q9C0G5

    Protein attributes for INTS5 Gene

    Size:
    1019 amino acids
    Molecular mass:
    107995 Da
    Quaternary structure:
    • Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12.
    SequenceCaution:
    • Sequence=AAH28025.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for INTS5 Gene

Proteomics data for INTS5 Gene at MOPED

Post-translational modifications for INTS5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for INTS5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for INTS5 Gene

Domains for INTS5 Gene

Protein Domains for INTS5 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with INTS5: view

No data available for Gene Families and UniProtKB/Swiss-Prot for INTS5 Gene

Function for INTS5 Gene

Molecular function for INTS5 Gene

UniProtKB/Swiss-Prot Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes

Gene Ontology (GO) - Molecular Function for INTS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16239144
genes like me logo Genes that share ontologies with INTS5: view

Phenotypes for INTS5 Gene

GenomeRNAi human phenotypes for INTS5:
genes like me logo Genes that share phenotypes with INTS5: view

miRNA for INTS5 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for INTS5 Gene

Localization for INTS5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for INTS5 Gene

Nucleus. Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for INTS5 Gene COMPARTMENTS Subcellular localization image for INTS5 gene
Compartment Confidence
nucleus 5
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for INTS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
GO:0032039 integrator complex IDA 16239144
genes like me logo Genes that share ontologies with INTS5: view

Pathways for INTS5 Gene

SuperPathways for INTS5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for INTS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016180 snRNA processing IDA 16239144
genes like me logo Genes that share ontologies with INTS5: view

No data available for Pathways by source for INTS5 Gene

Compounds for INTS5 Gene

(31) Novoseek inferred chemical compound relationships for INTS5 Gene

Compound -log(P) Hits PubMed IDs
pyridine 64.7 2
hydride 54.9 1
acetonitrile 51.5 4
platinum 49.9 1
carboxylate 48.6 1
genes like me logo Genes that share compounds with INTS5: view

Transcripts for INTS5 Gene

mRNA/cDNA for INTS5 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(318) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for INTS5 Gene

Integrator complex subunit 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for INTS5 Gene

No ASD Table

Relevant External Links for INTS5 Gene

GeneLoc Exon Structure for
INTS5
ECgene alternative splicing isoforms for
INTS5

Expression for INTS5 Gene

mRNA expression in normal human tissues for INTS5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for INTS5 Gene

SOURCE GeneReport for Unigene cluster for INTS5 Gene Hs.458390

genes like me logo Genes that share expressions with INTS5: view

Orthologs for INTS5 Gene

This gene was present in the common ancestor of animals.

Orthologs for INTS5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INTS5 36
  • 99.71 (n)
  • 99.8 (a)
INTS5 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia INTS5 36
  • 90.01 (n)
  • 96.76 (a)
KIAA1698 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia INTS5 36
  • 91.27 (n)
  • 97.55 (a)
INTS5 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ints5 36
  • 88.47 (n)
  • 95.38 (a)
Ints5 16
Ints5 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia INTS5 37
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ints5 36
  • 88.58 (n)
  • 95.29 (a)
chicken
(Gallus gallus)
Aves LOC101750875 36
  • 64.33 (n)
  • 65.91 (a)
lizard
(Anolis carolinensis)
Reptilia INTS5 37
  • 62 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1656 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ints5 36
  • 59.04 (n)
  • 61.12 (a)
Str.9132 36
zebrafish
(Danio rerio)
Actinopterygii Dr.17427 36
INTS5 (1 of 2) 37
  • 53 (a)
OneToMany
INTS5 (2 of 2) 37
  • 54 (a)
OneToMany
LOC564642 36
  • 57.35 (n)
  • 55.2 (a)
fruit fly
(Drosophila melanogaster)
Insecta omd 37
  • 23 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 26 (a)
OneToOne
Species with no ortholog for INTS5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for INTS5 Gene

ENSEMBL:
Gene Tree for INTS5 (if available)
TreeFam:
Gene Tree for INTS5 (if available)

Paralogs for INTS5 Gene

No data available for Paralogs for INTS5 Gene

Variants for INTS5 Gene

Sequence variations from dbSNP and Humsavar for INTS5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs2510074 -- 62,652,321(-) ttttt(G/T)ttttt intron-variant
rs2958232 -- 62,652,229(+) catga(A/G)aatcg intron-variant
rs3750989 -- 62,649,573(+) CCAGT(A/T)GCGTG synonymous-codon, reference
rs7926862 -- 62,653,398(+) CGCAC(C/G)CTGTC upstream-variant-2KB
rs9734446 -- 62,651,768(+) ttgag(G/T)cagaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for INTS5 Gene

Variant ID Type Subtype PubMed ID
nsv832182 CNV Gain+Loss 17160897

Relevant External Links for INTS5 Gene

HapMap Linkage Disequilibrium report
INTS5
Human Gene Mutation Database (HGMD)
INTS5

Disorders for INTS5 Gene

(3) Novoseek inferred disease relationships for INTS5 Gene

Disease -log(P) Hits PubMed IDs
congestion 6.18 1
epilepsy 0 2
ovarian cancer 0 2
genes like me logo Genes that share disorders with INTS5: view

No data available for UniProtKB/Swiss-Prot for INTS5 Gene

Publications for INTS5 Gene

  1. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PMID: 16239144) Baillat D. … Shiekhattar R. (Cell 2005) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for INTS5 Gene

Sources for INTS5 Gene

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