INTS4L1 Gene
pseudogene GIFtS: 32
GCID: GC07P064601
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integrator complex subunit 4-like 1
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Aliases
for INTS4L1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
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| Integrator Complex Subunit 4-Like 11 2 | | FLJ250371 |
| External Ids: | HGNC: 219251 | Entrez Gene: 2859052 | Ensembl: ENSG000001646697 | UniProtKB: Q96LV53 | | ORGUL members: | |
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| NONCODE:n385192 | |
Export aliases for INTS4L1 gene to outside databasesPrevious GC identifers: GC07P064241 GC11M073903
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Summaries
for INTS4L1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
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Genomic Views
for INTS4L1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NT_007933.15 NT_079593.2 NC_018918.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the INTS4L1 gene promoter:
E2F-4 E2F-3a E2F-5 IRF-1 E2F-2 POU3F2 CBF-B E2F E2F-1 CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for INTS4L1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INTS4L1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q11.21 Ensembl cytogenetic band: 7q11.21 HGNC cytogenetic band: 7q11.21INTS4L1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P064601: view genomic region
(about GC identifiers)
Start:
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64,601,603 bp from pter |
End:
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64,694,600 bp from pter |
Size:
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92,998 bases |
Orientation:
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plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 63,939,196-64,032,193 |
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Proteins
for INTS4L1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IN4L1_HUMAN, Q96LV5 (See
protein sequence)Recommended Name: Integrator complex subunit 4-like protein 1 Size: 439 amino acids; 48672 DaExplore the universe of human proteins at neXtProt for INTS4L1: NX_Q96LV5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96LV5
INTS4L1 Protein expression data from MOPED and PaxDb: About this image 
Human Recombinant Protein Products:
INTS4L1 Antibody Products:
Assay Products for INTS4L1: |
Protein
Domains /
Families
for INTS4L1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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INTS4L1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96LV5ProtoNet protein and cluster: Q96LV5 1 Blocks protein family: IPB000357 HEAT repeat
UniProtKB/Swiss-Prot: IN4L1_HUMAN, Q96LV5Similarity: Belongs to the Integrator subunit 4 familySimilarity: Contains 4 HEAT repeats |
Function
for INTS4L1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTS4L1 |
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Pathways & Interactions
for INTS4L1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for INTS4L1
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Drugs & Compounds
for INTS4L1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for INTS4L1
Search CenterWatch for drugs/clinical trials and news about INTS4L1 
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Transcripts
for INTS4L1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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REFSEQ mRNAs for INTS4L1 gene: NM_182596.1 Unigene Cluster for INTS4L1: Integrator complex subunit 4-like 1 Hs.567827 [show with all ESTs]Unigene Representative Sequence: XR_1716883 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000587624 ENST00000438455 ENST00000297235(uc003ttw.3)
Additional cDNA sequence: AK057766.1 XR_158834.2 XR_159091.2 XR_171688.1 5 DOTS entries: DT.40271105 DT.449744 DT.100784463 DT.102842922 DT.121127291 10 AceView cDNA sequences: AA322631 BE673512 NM_182596 BF221565 AK057766 Z21286 AW361819 AA360980 AV733217 BE694734
GeneLoc Exon Structure
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Expression
for INTS4L1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| INTS4L1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See INTS4L1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for INTS4L1
SOURCE GeneReport for Unigene cluster: Hs.567827
SABiosciences Custom PCR Arrays for INTS4L1
Primer
Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for INTS4L1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat INTS4L1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INTS4L1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INTS4L1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTS4L1 |
Orthologs
for INTS4L1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for INTS4L1 (if available)
TreeFam Gene Tree for INTS4L1 (if available) |
Paralogs
for INTS4L1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for INTS4L1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for INTS4L1 (64601603 - 64694600 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 22 variations for INTS4L1
15/21 CNVs (see all 21): 52268 52269 5239 7636 69932 53749 69935 9058 53866 5398 64839 3682 8564 32909 52270
1 Inversion: 37292 | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for INTS4L1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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Publications
for INTS4L1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for INTS4L1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with INTS4L1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for INTS4L1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing INTS4L1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing INTS4L1 gene
(According to HUGE)
About This Section
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Specialized Databases showing INTS4L1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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About This Section
| Patent Information for INTS4L1 gene:
Search GeneIP for patents involving INTS4L1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for INTS4L1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat INTS4L1 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing INTS4L1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INTS4L1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat INTS4L1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INTS4L1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INTS4L1 |
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 |  |  |  | |
| | | | Search Tocris compounds for INTS4L1 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTS4L1 |
|  |  |  | | | | Search ThermoFisher Antibodies for INTS4L1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INTS4L1 |
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GeneCards Homepage -
Last full update: 18 Mar 2013 -
Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013
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