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INTS4L1 Gene

pseudogene   GIFtS: 30
GCID: GC07P064601

Integrator Complex Subunit 4-Like 1

  Search for INTS4L1
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Integrator Complex Subunit 4-Like 11 2

External Ids:    HGNC: 219251   Entrez Gene: 2859052   Ensembl: ENSG000001646697   UniProtKB: Q96LV53   

Export aliases for INTS4L1 gene to outside databases

Previous GC identifers: GC07P064241 GC11M073903


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for INTS4L1 Gene:
INTS4L1 (integrator complex subunit 4-like 1) is a pseudogene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the INTS4L1 gene promoter:
         E2F-4   E2F-3a   E2F-5   IRF-1   E2F-2   POU3F2   CBF-B   E2F   E2F-1   CBF(2)   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat INTS4L1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.21   Ensembl cytogenetic band:  7q11.21   HGNC cytogenetic band: 7q11.21

INTS4L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INTS4L1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P064601:  view genomic region     (about GC identifiers)

Start:
64,601,603 bp from pter      End:
64,694,600 bp from pter
Size:
92,998 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 63,939,196-64,032,193     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IN4L1_HUMAN, Q96LV5 (See protein sequence)
Recommended Name: Integrator complex subunit 4-like protein 1  
Size: 439 amino acids; 48672 Da

Explore the universe of human proteins at neXtProt for INTS4L1: NX_Q96LV5

Explore proteomics data for INTS4L1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See INTS4L1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR011989 ARM-like
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q96LV5

    ProtoNet protein and cluster: Q96LV5

    1 Blocks protein domain: IPB000357 HEAT repeat

    UniProtKB/Swiss-Prot: IN4L1_HUMAN, Q96LV5
    Similarity: Belongs to the Integrator subunit 4 family
    Similarity: Contains 4 HEAT repeats


    INTS4L1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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      --

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for INTS4L1
    Interactions:

        Search GeneGlobe Interaction Network for INTS4L1

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for INTS4L1 (IN4L1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for INTS4L1 gene: 
    NM_182596.1  

    Unigene Cluster for INTS4L1:

    Integrator complex subunit 4-like 1
    Hs.567827  [show with all ESTs]
    Unigene Representative Sequence: XR_171688
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000587624 ENST00000438455 ENST00000297235(uc003ttw.3)
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    Additional mRNA sequence: 

    AK057766.1 XR_158834.2 XR_159091.2 XR_171688.1 

    5 DOTS entries:

    DT.40271105  DT.449744  DT.100784463  DT.102842922  DT.121127291 

    10 AceView cDNA sequences:

    AA322631 BE673512 Z21286 AK057766 BF221565 NM_182596 AW361819 AA360980 
    AV733217 BE694734 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    INTS4L1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    INTS4L1 Expression
    About this image

    INTS4L1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    INTS4L1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.567827
        Custom PCR Arrays for INTS4L1
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    ENSEMBL Gene Tree for INTS4L1 (if available)
    TreeFam Gene Tree for INTS4L1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for INTS4L1 gene
    2 SIMAP similar genes for INTS4L1 using alignment to 1 protein entry:     IN4L1_HUMAN:
    INTS4L2    INTS4

    INTS4L1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for INTS4L1 (see all 1617)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1118107551,2
    C--61265006(+) GCGCAC/GGCAAA 2 H Q mis10--------
    rs24194321,2
    --61377048(-) AGGCAA/TGTTGG 1 -- int10--------
    rs24194311,2
    --61377145(-) AGCAAC/GAGAAG 1 -- int10--------
    rs2003363611,2
    C--63938074(+) TATTC-/TGTT  
            
    TGTTT
    1 -- us2k10--------
    rs29433891,2
    C--63939577(+) GGGCGA/GGTGCT 1 -- int10--------
    rs2011436161,2
    C--63940464(+) TCAAA-/AACAACAA 1 -- int10--------
    rs1133137881,2
    F--63942286(+) GATGAA/G/TATGAG 1 -- int11CSA 2
    rs1464689241,2
    C--63942797(+) AAATG-/ATGAA 
            
    ATGAA
    1 -- int10--------
    rs2002001591,2
    C--63943903(+) ATGAA-/ATGATGAA 1 -- int10--------
    rs26719471,2
    --63956463(+) ctttgC/Tcatga 1 -- int10--------

    HapMap Linkage Disequilibrium report for INTS4L1 (64601603 - 64694600 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for INTS4L1 (see all 36):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1213e199CNV Deletion23128226
    nsv435849CNV Deletion17901297
    esv2422276CNV Deletion17116639
    esv2665525CNV Deletion23128226
    dgv1147e201CNV Deletion23290073
    esv2734586CNV Deletion23290073
    esv2422405CNV Duplication17116639
    nsv820581CNV Duplication20802225
    dgv818n27CNV Loss19166990
    dgv226e55CNV Loss17911159

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for INTS4L1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with INTS4L1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 285905 HGNC: 21925 AceView: FLJ25037 Ensembl:ENSG00000164669 euGenes: HUgn285905
    ECgene: INTS4L1 H-InvDB: INTS4L1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for INTS4L1 gene:
    Search GeneIP for patents involving INTS4L1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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