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INTS4 Gene

protein-coding   GIFtS: 51
GCID: GC11M077589

Integrator Complex Subunit 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Integrator Complex Subunit 41 2
INT42 5
MST0932
MSTP0932
Int43

External Ids:    HGNC: 250481   Entrez Gene: 921052   Ensembl: ENSG000001492627   OMIM: 6113485   UniProtKB: Q96HW73   

Export aliases for INTS4 gene to outside databases

Previous GC identifers: GC11M077269 GC07P064459


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for INTS4 Gene:
INTS4 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II
large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM
180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 (PubMed 16239144)).(supplied by OMIM, Mar 2008)

GeneCards Summary for INTS4 Gene:
INTS4 (integrator complex subunit 4) is a protein-coding gene. Diseases associated with INTS4 include down syndrome, and alzheimer's disease.

UniProtKB/Swiss-Prot: INT4_HUMAN, Q96HW7
Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2
transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal
domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the INTS4 gene promoter:
         STAT5A   Tal-1beta   E4BP4   RORalpha2   MEF-2A   AREB6   POU2F1   POU2F1a   aMEF-2   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidINTS4 promoter sequence
   Search Chromatin IP Primers for INTS4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat INTS4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q14.1   Ensembl cytogenetic band:  11q14.1   HGNC cytogenetic band: 11q14.1

INTS4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INTS4 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M077589:  view genomic region     (about GC identifiers)

Start:
77,589,766 bp from pter      End:
77,705,724 bp from pter
Size:
115,959 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: INT4_HUMAN, Q96HW7 (See protein sequence)
Recommended Name: Integrator complex subunit 4  
Size: 963 amino acids; 108171 Da
Subunit: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5,
INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12
Secondary accessions: Q2YD62 Q6PJG4 Q7Z4E7 Q96G32 Q96GA1 Q9BRC0
Alternative splicing: 4 isoforms:  Q96HW7-1   Q96HW7-2   Q96HW7-3   Q96HW7-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for INTS4: NX_Q96HW7

Explore proteomics data for INTS4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys593
  • Modification sites at PhosphoSitePlus

  • See INTS4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_291025.3  
    ENSEMBL proteins: 
     ENSP00000407787   ENSP00000434466   ENSP00000433644   ENSP00000432776   ENSP00000436248  
     ENSP00000435758   ENSP00000441084  

    INTS4 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for INTS4
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    Novus Biologicals INTS4 Protein
    Novus Biologicals INTS4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for INTS4

    INTS4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for INTS4
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    ThermoFisher Antibodies for INTS4
    LSBio Antibodies in human, mouse, rat for INTS4

    INTS4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for INTS4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for INTS4
    Cloud-Clone Corp. CLIAs for INTS4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR011989 ARM-like
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q96HW7

    ProtoNet protein and cluster: Q96HW7

    1 Blocks protein domain: IPB000357 HEAT repeat

    UniProtKB/Swiss-Prot: INT4_HUMAN, Q96HW7
    Similarity: Belongs to the Integrator subunit 4 family
    Similarity: Contains 8 HEAT repeats


    INTS4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: INT4_HUMAN, Q96HW7
    Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2
    transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal
    domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI16239144
         
    INTS4 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for INTS4:
     Increased circadian period len  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for INTS4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for INTS4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for INTS4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for INTS4

    miRNA
    Products:
        
    miRTarBase miRNAs that target INTS4:
    hsa-mir-197-3p (MIRT048141), hsa-mir-155-5p (MIRT020869), hsa-mir-455-3p (MIRT037855)

    Block miRNA regulation of human, mouse, rat INTS4 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate INTS4:
    hsa-miR-125a-3p hsa-miR-513c hsa-miR-514b-5p
    SwitchGear 3'UTR luciferase reporter plasmidINTS4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for INTS4
    Predesigned siRNA for gene silencing in human, mouse, rat INTS4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for INTS4

    Clone
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    OriGene clones in human, mouse for INTS4 (see all 7)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: INTS4 (NM_033547)
    Sino Biological Human cDNA Clone for INTS4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INTS4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INTS4

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for INTS4
    Browse ESI BIO Cell Lines and PureStem Progenitors for INTS4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTS4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    INT4_HUMAN, Q96HW7: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032039integrator complex IDA16239144

    INTS4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for INTS4
    Interactions:

        Search GeneGlobe Interaction Network for INTS4

    Selected Interacting proteins for INTS4 (Q96HW73) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    INTS1Q8N2013I2D: score=1 
    INTS3Q68E013I2D: score=1 
    INTS5Q6P9B93I2D: score=1 
    INTS6Q9UL033I2D: score=1 
    KIAA0513O602683I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016180snRNA processing IDA16239144

    INTS4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for INTS4 (INT4)

    Selected Novoseek inferred chemical compound relationships for INTS4 gene (see all 45)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2-(hydroxymethyl)pyridine 83 1 16411688 (1)
    dimethyl acetylenedicarboxylate 71.7 2 19199302 (1)
    2,2'-bipyridine 67.5 2 18618562 (1), 20199051 (1)
    carborane 66.9 1 17712445 (1)
    acetonitrile 66 4 19489554 (1), 12425637 (1), 11196963 (1), 20025254 (1)
    2-methyltetrahydrofuran 64.8 1 16390078 (1)
    pyridine 61.4 1 19308980 (1)
    carboxylate 60.3 1 15252563 (1)
    tetrahydrofuran 58.1 1 16390078 (1)
    rhenium 57.7 1 11575768 (1)



    INTS4 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for INTS4 gene: 
    NM_033547.3  

    Unigene Cluster for INTS4:

    Integrator complex subunit 4
    Hs.533723  [show with all ESTs]
    Unigene Representative Sequence: BC015664
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000433818(uc001oyt.3) ENST00000534064(uc001oys.3) ENST00000533180
    ENST00000525268 ENST00000531059 ENST00000525931 ENST00000529807(uc001oyu.1)
    ENST00000534408(uc001oyv.1) ENST00000524766 ENST00000527522 ENST00000535943

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat INTS4 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate INTS4:
    hsa-miR-125a-3p hsa-miR-513c hsa-miR-514b-5p
    SwitchGear 3'UTR luciferase reporter plasmidINTS4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for INTS4
    Predesigned siRNA for gene silencing in human, mouse, rat INTS4
    Clone
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    OriGene clones in human, mouse for INTS4 (see all 7)
    OriGene ORF clones in mouse, rat for INTS4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: INTS4 (NM_033547)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INTS4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INTS4
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for INTS4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat INTS4
      QuantiTect SYBR Green Assays in human, mouse, rat INTS4
      QuantiFast Probe-based Assays in human, mouse, rat INTS4

    Additional mRNA sequence: 

    AF172822.1 AK000455.1 AK096604.1 AK290866.1 AL834171.1 BC006369.1 BC008013.1 BC009859.2 
    BC009995.2 BC015664.2 BC018672.1 

    10 DOTS entries:

    DT.449744  DT.100784463  DT.91767154  DT.95376424  DT.120714327  DT.40237509  DT.86846922  DT.100661709 
    DT.40270646  DT.86857872 

    Selected AceView cDNA sequences (see all 192):

    BC009859 AI002913 NM_033547 T93283 BU932126 BM705496 AW467450 AA322631 
    AI096821 BU844612 AI523929 AA708631 BC008013 AA908729 BU170247 AA765511 
    C17892 BQ216049 BE207815 R42990 BC015664 AK000455 AA443913 BM824605 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    INTS4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAGGTGGAA
    INTS4 Expression
    About this image

    INTS4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    INTS4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.533723
        Custom PCR Arrays for INTS4
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for INTS4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat INTS4
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    QuantiFast Probe-based Assays in human, mouse, rat INTS4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTS4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for INTS4 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ints41 , 5 integrator complex subunit 41, 5 90.27(n)1
    96.88(a)1
      7 (53.52 cM)5
    1018611  NM_027256.21  NP_081532.11 
     974809565 
    chicken
    (Gallus gallus)
    Aves INTS41 integrator complex subunit 4 79.96(n)
    90.45(a)
      419028  XM_417220.4  XP_417220.3 
    lizard
    (Anolis carolinensis)
    Reptilia INTS46
    integrator complex subunit 4
    87(a)
    1 ↔ 1
    GL343337.1(595295-628486)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.297292 Xenopus laevis transcribed sequences 76.1(n)    BJ039676.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch73-39g20.41 si:ch73-39g20.4 70.3(n)
    79.23(a)
      564681  XM_001923684.2  XP_001923719.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta IntS41 Integrator 4 48.08(n)
    39.66(a)
      31793  NM_132260.2  NP_572488.1 
    worm
    (Caenorhabditis elegans)
    Secernentea W04A4.56
    Protein W04A4.5 (W04A4.5) mRNA, complete cds
    20(a)
    1 ↔ 1
    I(13663485-13674964) WBGene00012234


    ENSEMBL Gene Tree for INTS4 (if available)
    TreeFam Gene Tree for INTS4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for INTS4 gene
    2 SIMAP similar genes for INTS4 using alignment to 3 protein entries:     INT4_HUMAN (see all proteins):
    INTS4L1    INTS4L2

    INTS4 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for INTS4
    PGOHUM00000232837 PGOHUM00000258280 PGOHUM00000260355 PGOHUM00000258281 PGOHUM00000260358


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for INTS4 (see all 2249)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs347675921,2
    C--77566332(+) AAAAA-/A/AA  
            
    TGTAT
    1 -- int11NA 2
    rs1827388931,2
    --77589352(+) GCAGTA/GAGCCA 1 -- ds50010--------
    rs1872642401,2
    --77589387(+) TGAGCA/GACACA 1 -- ds50010--------
    rs1917186871,2
    --77589391(+) CGACAA/CAGCAA 1 -- ds50010--------
    rs1173990701,2
    F--77589560(+) AAAAAA/GAAAGT 1 -- ds50011Minor allele frequency- G:0.02EA 120
    rs1846337171,2
    --77589580(+) AAAGCA/GGCCTT 1 -- ds50010--------
    rs729394391,2
    C--77589649(+) CAGTTA/GTCAGG 1 -- ds50015Minor allele frequency- G:0.18NA CSA WA EA 362
    rs1512093431,2
    --77589897(+) CCTTAA/GGCCTA 1 -- ut310--------
    rs1891494091,2
    --77589906(+) TACACA/GTCAAT 1 -- ut310--------
    rs1932560961,2
    --77589911(+) ATCAAC/TTCCAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for INTS4 (77589766 - 77705724 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for INTS4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv507601CNV Insertion20534489
    nsv400CNV Insertion18451855
    nsv8841CNV Loss18304495
    nsv524537CNV Loss19592680
    nsv526268CNV Gain19592680
    nsv520740CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing INTS4
    DNA2.0 Custom Variant and Variant Library Synthesis for INTS4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611348    OMIM disorders: --

    6 diseases for INTS4:    
    About MalaCards
    down syndrome    alzheimer's disease    retinoblastoma    amyotrophic lateral sclerosis
    lateral sclerosis    malaria


    INTS4 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for INTS4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alzheimers disease 0 2 7748461 (1), 1321237 (1)

    Genetic Association Database (GAD): INTS4

    Export disorders for INTS4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for INTS4 gene, integrated from 10 sources (see all 168):
    (articles sorted by number of sources associating them with INTS4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PubMed id 16239144)1, 2, 3 Baillat D....Shiekhattar R. (Cell 2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PubMed id 24163370)1 Lu L....Zhang L. (J. Biol. Chem. 2013)
    4. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    6. The integrator complex is required for integrity of Cajal bodies. (PubMed id 22250197)1 Takata H....Shibahara K. (J. Cell. Sci. 2012)
    7. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    8. Comparative proteomic analysis identifies a role for SUMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (Sci Signal 2011)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 92105 HGNC: 25048 AceView: MGC16733 Ensembl:ENSG00000149262 euGenes: HUgn92105
    ECgene: INTS4 H-InvDB: INTS4

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for INTS4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for INTS4 gene:
    Search GeneIP for patents involving INTS4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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