INTS4 Gene
protein-coding GIFtS: 47
GCID: GC11M077589
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integrator complex subunit 4
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Aliases
for INTS4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Integrator Complex Subunit 41 2 | | INT41 2 | | MST0931 2 | | MGC167331 | | MSTP0932 | | Int43 |
Export aliases for INTS4 gene to outside databasesPrevious GC identifers: GC11M077269 GC07P064459 |
Summaries
for INTS4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for INTS4:
INTS4 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II largesubunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2(RNU2; MIM 180690) (Baillat et al., 2005 (PubMed 16239144)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: INT4_HUMAN, Q96HW7Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminaldomain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes
|
Genomic Views
for INTS4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the INTS4 gene promoter:
STAT5A Tal-1beta E4BP4 RORalpha2 MEF-2A AREB6 POU2F1 POU2F1a aMEF-2 ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for INTS4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INTS4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q14.1 Ensembl cytogenetic band: 11q14.1 HGNC cytogenetic band: 11q14.1INTS4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M077589: view genomic region
(about GC identifiers)
Start:
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77,589,766 bp from pter |
End:
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77,705,724 bp from pter |
Size:
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115,959 bases |
Orientation:
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minus strand |
1 alternative location:
| Chr7+,CRA_TCAG 64,459,439-64,521,195 |
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Proteins
for INTS4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: INT4_HUMAN, Q96HW7 (See
protein sequence)Recommended Name: Integrator complex subunit 4 Size: 963 amino acids; 108171 Da
Subunit: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6,INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12
Subcellular location: Nucleus (Probable)
Secondary accessions: Q2YD62 Q6PJG4 Q7Z4E7 Q96G32 Q96GA1 Q9BRC0Alternative splicing: 4 isoforms: Q96HW7-1 Q96HW7-2 Q96HW7-3 Q96HW7-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for INTS4: NX_Q96HW7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96HW7
INTS4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_291025.3
ENSEMBL proteins: ENSP00000407787 ENSP00000434466 ENSP00000433644 ENSP00000432776 ENSP00000436248 ENSP00000435758 ENSP00000441084
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
INTS4 for ontologies About GeneDecksing
INTS4 Antibody Products:
Assay Products for INTS4: |
Protein
Domains /
Families
for INTS4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
INTS4 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96HW7ProtoNet protein and cluster: Q96HW7 1 Blocks protein family: IPB000357 HEAT repeat
UniProtKB/Swiss-Prot: INT4_HUMAN, Q96HW7Similarity: Belongs to the Integrator subunit 4 familySimilarity: Contains 8 HEAT repeats |
Function
for INTS4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: INT4_HUMAN, Q96HW7Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminaldomain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for INTS4 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for INTS4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: INTS4 (NM_033547) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for INTS4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INTS4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTS4 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
INTS4 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for INTS4:
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Pathways & Interactions
for INTS4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for INTS4
5/6 Interacting proteins for INTS4 (Q96HW73) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
INTS4 for ontologies About GeneDecksing
|
Drugs & Compounds
for INTS4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
INTS4 for compounds About GeneDecksing
 Browse Tocris compounds for INTS4
10/45 Novoseek chemical compound relationships for INTS4 gene (see all 45) About this table
Search CenterWatch for drugs/clinical trials and news about INTS4 / INT4
|
Transcripts
for INTS4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for INTS4 gene: NM_033547.3 Unigene Cluster for INTS4: Integrator complex subunit 4 Hs.533723 [show with all ESTs]Unigene Representative Sequence: BC01566411 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000433818(uc001oyt.3) ENST00000534064(uc001oys.3) ENST00000533180
ENST00000531059 ENST00000525268 ENST00000525931 ENST00000529807(uc001oyu.1)
ENST00000534408(uc001oyv.1) ENST00000524766 ENST00000527522 ENST00000535943
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for INTS4 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for INTS4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: INTS4 (NM_033547) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for INTS4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INTS4 |
Additional cDNA sequence: AF172822.1 AK000455.1 AK096604.1 AK290866.1 AL834171.1 BC006369.1 BC008013.1 BC009859.2 BC009995.2 BC015664.2 BC018672.1 10 DOTS entries: DT.449744 DT.100784463 DT.91767154 DT.95376424 DT.120714327 DT.40237509 DT.86846922 DT.100661709 DT.40270646 DT.86857872 24/192 AceView cDNA sequences (see all 192): BE207815 BX402388 BM972671 AI921466 BC015664 R42990 BM705496 BU932126 T93283 BU170247 BC009995 AA908729 AI002913 AI523929 BQ216049 AI096821 BC009859 BM754780 BC006369 BU844612 NM_033547 AA322631 AA443913 AA765511
GeneLoc Exon Structure
|
Expression
for INTS4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| INTS4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCAGGTGGAA
About this image
See INTS4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for INTS4
SOURCE GeneReport for Unigene cluster: Hs.533723
SABiosciences Custom PCR Arrays for INTS4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for INTS4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat INTS4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INTS4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INTS4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTS4 |
Orthologs
for INTS4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for INTS4 gene from 9/22 species (see all 22) About this table
ENSEMBL Gene Tree for INTS4 (if available)
TreeFam Gene Tree for INTS4 (if available) |
Paralogs
for INTS4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for INTS4 gene
2 SIMAP similar genes for INTS4 using alignment to 3 protein entries: INT4_HUMAN (see all proteins):INTS4L1 INTS4L2
INTS4 for paralogs About GeneDecksing
5 Pseudogenes.org Pseudogenes for INTS4
PGOHUM00000232837 PGOHUM00000258280 PGOHUM00000260355 PGOHUM00000258281 PGOHUM00000260358
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Genomic Variants
for INTS4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for INTS4 (77589766 - 77705724 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for INTS4
3 CNVs: 31830 85864 75711 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing INTS4 |
|
Disorders
/ Diseases
for INTS4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
INTS4 for disorders About GeneDecksing
OMIM gene information: 611348
OMIM disorders: --
5  diseases for INTS4: About MalaCardsalzheimer's disease down syndrome seizures retinoblastoma
alcoholism
1 Novoseek disease relationship for INTS4 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| alzheimers disease |
0 |
2 |
7748461 (1), 1321237 (1) |
Export disorders for INTS4 gene to outside databases
|
Publications
for INTS4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for INTS4 gene, integrated from 9 sources (see all 165):
(articles sorted by number of sources associating them with INTS4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PubMed id 16239144)1, 2, 3 Baillat D....Shiekhattar R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Streamlined analysis schema for high-throughput ident ification of endogenous protein complexes. (PubMed id 20133760)1 Malovannaya A....Qin J. (2010)
- System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)1 Golebiowski F....Hay R.T. (2009)
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External Searches for INTS4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing INTS4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing INTS4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing INTS4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for INTS4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for INTS4 gene:
Search GeneIP for patents involving INTS4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for INTS4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for INTS4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for INTS4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for INTS4 | | | OriGene Protein Over-expression Lysate for INTS4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for INTS4 | | OriGene 3'-UTR Clone for INTS4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for INTS4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for INTS4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for INTS4 | | OriGene Custom Protein Services for INTS4 | | | OriGene Custom Immunoassay Development | | |
| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat INTS4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing INTS4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INTS4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat INTS4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INTS4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INTS4 |
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| | | | Search Tocris compounds for INTS4 |
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 | | | INTS4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTS4 |
|  |  |  | | | | ThermoFisher Antibodies for INTS4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INTS4 |
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