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Aliases for INTS4 Gene

Aliases for INTS4 Gene

  • Integrator Complex Subunit 4 2 3 5
  • INT4 3 4
  • MSTP093 3
  • MST093 3

External Ids for INTS4 Gene

Previous GeneCards Identifiers for INTS4 Gene

  • GC11M077269
  • GC11M077589
  • GC07P064459

Summaries for INTS4 Gene

Entrez Gene Summary for INTS4 Gene

  • INTS4 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]

GeneCards Summary for INTS4 Gene

INTS4 (Integrator Complex Subunit 4) is a Protein Coding gene. Diseases associated with INTS4 include leigh syndrome. Among its related pathways are Gene Expression and RNA Polymerase II Transcription Initiation And Promoter Clearance. GO annotations related to this gene include binding.

UniProtKB/Swiss-Prot for INTS4 Gene

  • Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INTS4 Gene

Genomics for INTS4 Gene

Regulatory Elements for INTS4 Gene

Promoters for INTS4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around INTS4 on UCSC Golden Path with GeneCards custom track

Genomic Location for INTS4 Gene

Chromosome:
11
Start:
77,878,720 bp from pter
End:
77,994,842 bp from pter
Size:
116,123 bases
Orientation:
Minus strand

Genomic View for INTS4 Gene

Genes around INTS4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INTS4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INTS4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INTS4 Gene

Proteins for INTS4 Gene

  • Protein details for INTS4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96HW7-INT4_HUMAN
    Recommended name:
    Integrator complex subunit 4
    Protein Accession:
    Q96HW7
    Secondary Accessions:
    • Q2YD62
    • Q6PJG4
    • Q7Z4E7
    • Q96G32
    • Q96GA1
    • Q9BRC0

    Protein attributes for INTS4 Gene

    Size:
    963 amino acids
    Molecular mass:
    108171 Da
    Quaternary structure:
    • Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12.

    Alternative splice isoforms for INTS4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for INTS4 Gene

Proteomics data for INTS4 Gene at MOPED

Post-translational modifications for INTS4 Gene

  • Ubiquitination at Lys 593
  • Modification sites at PhosphoSitePlus

Other Protein References for INTS4 Gene

No data available for DME Specific Peptides for INTS4 Gene

Domains & Families for INTS4 Gene

Protein Domains for INTS4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for INTS4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96HW7

UniProtKB/Swiss-Prot:

INT4_HUMAN :
  • Belongs to the Integrator subunit 4 family.
  • Contains 8 HEAT repeats.
Family:
  • Belongs to the Integrator subunit 4 family.
Similarity:
  • Contains 8 HEAT repeats.
genes like me logo Genes that share domains with INTS4: view

No data available for Gene Families for INTS4 Gene

Function for INTS4 Gene

Molecular function for INTS4 Gene

UniProtKB/Swiss-Prot Function:
Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.
genes like me logo Genes that share phenotypes with INTS4: view

Animal Model Products

miRNA for INTS4 Gene

miRTarBase miRNAs that target INTS4

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for INTS4 Gene

Localization for INTS4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for INTS4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for INTS4 Gene COMPARTMENTS Subcellular localization image for INTS4 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for INTS4 Gene

Pathways & Interactions for INTS4 Gene

genes like me logo Genes that share pathways with INTS4: view

Pathways by source for INTS4 Gene

2 Reactome pathways for INTS4 Gene

Gene Ontology (GO) - Biological Process for INTS4 Gene

None

No data available for SIGNOR curated interactions for INTS4 Gene

Drugs & Compounds for INTS4 Gene

(12) Drugs for INTS4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(33) Additional Compounds for INTS4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with INTS4: view

Transcripts for INTS4 Gene

Unigene Clusters for INTS4 Gene

Integrator complex subunit 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for INTS4 Gene

No ASD Table

Relevant External Links for INTS4 Gene

GeneLoc Exon Structure for
INTS4
ECgene alternative splicing isoforms for
INTS4

Expression for INTS4 Gene

mRNA expression in normal human tissues for INTS4 Gene

Protein differential expression in normal tissues from HIPED for INTS4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.1), Lymph node (9.8), and CD8 Tcells (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for INTS4 Gene



SOURCE GeneReport for Unigene cluster for INTS4 Gene Hs.533723

genes like me logo Genes that share expression patterns with INTS4: view

Protein tissue co-expression partners for INTS4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for INTS4 Gene

Orthologs for INTS4 Gene

This gene was present in the common ancestor of animals.

Orthologs for INTS4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia INTS4 35
  • 92.52 (n)
  • 97.09 (a)
INTS4 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia INTS4 35
  • 92.42 (n)
  • 97.72 (a)
-- 36
  • 98 (a)
OneToMany
-- 36
  • 87 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ints4 35
  • 90.27 (n)
  • 96.88 (a)
Ints4 16
Ints4 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia INTS4 35
  • 99.69 (n)
  • 100 (a)
INTS4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ints4 35
  • 89.93 (n)
  • 96.78 (a)
oppossum
(Monodelphis domestica)
Mammalia INTS4 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves INTS4 35
  • 79.96 (n)
  • 90.45 (a)
INTS4 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia INTS4 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ints4 35
  • 75.08 (n)
  • 84.57 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.29729 35
zebrafish
(Danio rerio)
Actinopterygii si:ch73-39g20.4 35
  • 70.3 (n)
  • 79.23 (a)
INTS4 36
  • 78 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001286 35
  • 47.79 (n)
  • 39.1 (a)
fruit fly
(Drosophila melanogaster)
Insecta IntS4 35
  • 48.08 (n)
  • 39.66 (a)
IntS4 36
  • 33 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea W04A4.5 36
  • 20 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
OneToOne
Species with no ortholog for INTS4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for INTS4 Gene

ENSEMBL:
Gene Tree for INTS4 (if available)
TreeFam:
Gene Tree for INTS4 (if available)

Paralogs for INTS4 Gene

(2) SIMAP similar genes for INTS4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with INTS4: view

No data available for Paralogs for INTS4 Gene

Variants for INTS4 Gene

Sequence variations from dbSNP and Humsavar for INTS4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs108843 -- 77,886,440(+) AGGCC(C/T)GCGGC intron-variant
rs608389 -- 77,884,596(-) ATATT(C/T)ACATA intron-variant
rs619142 -- 77,936,986(-) TGTTG(C/T)CGAGG intron-variant
rs658398 -- 77,884,671(+) AACTG(C/T)GGAAG intron-variant
rs611906 -- 77,881,150(+) ACTCA(A/T)GCAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for INTS4 Gene

Variant ID Type Subtype PubMed ID
nsv520740 CNV Gain 19592680
nsv524537 CNV Loss 19592680
nsv507601 CNV Insertion 20534489
nsv8841 CNV Loss 18304495
nsv400 CNV Insertion 18451855
nsv526268 CNV Gain 19592680

Variation tolerance for INTS4 Gene

Residual Variation Intolerance Score: 10.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.53; 55.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for INTS4 Gene

HapMap Linkage Disequilibrium report
INTS4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INTS4 Gene

Disorders for INTS4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for INTS4 Gene - From: GeneCards

Disorder Aliases PubMed IDs
leigh syndrome
  • leigh syndrome due to mitochondrial complex i deficiency
- elite association - COSMIC cancer census association via MalaCards
Search INTS4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for INTS4

Genetic Association Database (GAD)
INTS4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
INTS4
genes like me logo Genes that share disorders with INTS4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for INTS4 Gene

Publications for INTS4 Gene

  1. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PMID: 16239144) Baillat D. … Shiekhattar R. (Cell 2005) 2 3 4 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for INTS4 Gene

Sources for INTS4 Gene

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