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Aliases for INTS4 Gene

Aliases for INTS4 Gene

  • Integrator Complex Subunit 4 2 3
  • INT4 3 4 6
  • MSTP093 3
  • MST093 3

External Ids for INTS4 Gene

Summaries for INTS4 Gene

Entrez Gene Summary for INTS4 Gene

  • INTS4 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]

GeneCards Summary for INTS4 Gene

INTS4 (Integrator Complex Subunit 4) is a Protein Coding gene.

UniProtKB/Swiss-Prot for INTS4 Gene

  • Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INTS4 Gene

Genomics for INTS4 Gene

Genomic Location for INTS4 Gene

Start:
77,878,720 bp from pter
End:
77,994,718 bp from pter
Size:
115,999 bases
Orientation:
Minus strand

Genomic View for INTS4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for INTS4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INTS4 Gene

Regulatory Elements for INTS4 Gene

Proteins for INTS4 Gene

  • Protein details for INTS4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96HW7-INT4_HUMAN
    Recommended name:
    Integrator complex subunit 4
    Protein Accession:
    Q96HW7
    Secondary Accessions:
    • Q2YD62
    • Q6PJG4
    • Q7Z4E7
    • Q96G32
    • Q96GA1
    • Q9BRC0

    Protein attributes for INTS4 Gene

    Size:
    963 amino acids
    Molecular mass:
    108171 Da
    Quaternary structure:
    • Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12.

    Alternative splice isoforms for INTS4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for INTS4 Gene

Proteomics data for INTS4 Gene at MOPED

Post-translational modifications for INTS4 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys593

Other Protein References for INTS4 Gene

No data available for DME Specific Peptides for INTS4 Gene

Domains for INTS4 Gene

Protein Domains for INTS4 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

INT4_HUMAN
Family:
  • Belongs to the Integrator subunit 4 family.:
    • Q96HW7
Similarity:
  • Contains 8 HEAT repeats.:
    • Q96HW7
genes like me logo Genes that share domains with INTS4: view

No data available for Gene Families for INTS4 Gene

Function for INTS4 Gene

Molecular function for INTS4 Gene

UniProtKB/Swiss-Prot Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes

Gene Ontology (GO) - Molecular Function for INTS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 16239144
genes like me logo Genes that share ontologies with INTS4: view

Phenotypes for INTS4 Gene

genes like me logo Genes that share phenotypes with INTS4: view

miRNA for INTS4 Gene

miRTarBase miRNAs that target INTS4

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for INTS4 Gene

Localization for INTS4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for INTS4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for INTS4 Gene COMPARTMENTS Subcellular localization image for INTS4 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for INTS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032039 integrator complex IDA 16239144
genes like me logo Genes that share ontologies with INTS4: view

Pathways for INTS4 Gene

SuperPathways for INTS4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for INTS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016180 snRNA processing IDA 16239144
genes like me logo Genes that share ontologies with INTS4: view

No data available for Pathways by source for INTS4 Gene

Compounds for INTS4 Gene

(45) Novoseek inferred chemical compound relationships for INTS4 Gene

Compound -log(P) Hits PubMed IDs
2-(hydroxymethyl)pyridine 83 1
dimethyl acetylenedicarboxylate 71.7 1
2,2-bipyridine 67.5 2
carborane 66.9 1
acetonitrile 66 4
genes like me logo Genes that share compounds with INTS4: view

Transcripts for INTS4 Gene

Unigene Clusters for INTS4 Gene

Integrator complex subunit 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for INTS4 Gene

No ASD Table

Relevant External Links for INTS4 Gene

GeneLoc Exon Structure for
INTS4
ECgene alternative splicing isoforms for
INTS4

Expression for INTS4 Gene

mRNA expression in normal human tissues for INTS4 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for INTS4 Gene

SOURCE GeneReport for Unigene cluster for INTS4 Gene Hs.533723

genes like me logo Genes that share expressions with INTS4: view

Orthologs for INTS4 Gene

This gene was present in the common ancestor of animals.

Orthologs for INTS4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INTS4 36
  • 99.69 (n)
  • 100 (a)
INTS4 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia INTS4 36
  • 92.52 (n)
  • 97.09 (a)
INTS4 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 98 (a)
OneToMany
-- 37
  • 87 (a)
OneToMany
INTS4 36
  • 92.42 (n)
  • 97.72 (a)
mouse
(Mus musculus)
Mammalia Ints4 36
  • 90.27 (n)
  • 96.88 (a)
Ints4 16
Ints4 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia INTS4 37
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ints4 36
  • 89.93 (n)
  • 96.78 (a)
chicken
(Gallus gallus)
Aves INTS4 36
  • 79.96 (n)
  • 90.45 (a)
INTS4 37
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia INTS4 37
  • 87 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.29729 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ints4 36
  • 75.08 (n)
  • 84.57 (a)
zebrafish
(Danio rerio)
Actinopterygii INTS4 37
  • 78 (a)
OneToOne
si:ch73-39g20.4 36
  • 70.3 (n)
  • 79.23 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001286 36
  • 47.79 (n)
  • 39.1 (a)
fruit fly
(Drosophila melanogaster)
Insecta IntS4 36
  • 48.08 (n)
  • 39.66 (a)
IntS4 37
  • 33 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea W04A4.5 37
  • 20 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 39 (a)
OneToOne
Species with no ortholog for INTS4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for INTS4 Gene

ENSEMBL:
Gene Tree for INTS4 (if available)
TreeFam:
Gene Tree for INTS4 (if available)

Paralogs for INTS4 Gene

Selected SIMAP similar genes for INTS4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with INTS4: view

No data available for Paralogs for INTS4 Gene

Variants for INTS4 Gene

Sequence variations from dbSNP and Humsavar for INTS4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs108843 -- 77,886,440(+) AGGCC(C/T)GCGGC intron-variant
rs581807 -- 77,885,727(+) AGCAG(A/G)AGAAT intron-variant
rs581906 -- 77,936,836(-) ATTAC(A/G)CATGC intron-variant
rs582582 -- 77,954,848(-) cccca(C/G/T)gctgt intron-variant
rs582866 -- 77,886,521(+) GTAAA(C/T)GGCGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for INTS4 Gene

Variant ID Type Subtype PubMed ID
nsv520740 CNV Gain 19592680
nsv524537 CNV Loss 19592680
nsv507601 CNV Insertion 20534489
nsv8841 CNV Loss 18304495
nsv400 CNV Insertion 18451855
nsv526268 CNV Gain 19592680

Relevant External Links for INTS4 Gene

HapMap Linkage Disequilibrium report
INTS4

Disorders for INTS4 Gene

(1) Novoseek inferred disease relationships for INTS4 Gene

Disease -log(P) Hits PubMed IDs
alzheimers disease 0 2

Relevant External Links for INTS4

Genetic Association Database (GAD)
INTS4
genes like me logo Genes that share disorders with INTS4: view

No data available for UniProtKB/Swiss-Prot for INTS4 Gene

Publications for INTS4 Gene

  1. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PMID: 16239144) Baillat D. … Shiekhattar R. (Cell 2005) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. A germline-specific class of small RNAs binds mammalian Piwi proteins. (PMID: 16751776) Girard A. … Carmell M.A. (Nature 2006) 3
  4. Characterization of KIAA0513, a novel signaling molecule that interacts with modulators of neuroplasticity, apoptosis, and the cytoskeleton. (PMID: 17010949) Lauriat T.L. … McInnes L.A. (Brain Res. 2006) 3
  5. Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PMID: 17643375) Jeronimo C. … Coulombe B. (Mol. Cell 2007) 3

Products for INTS4 Gene

Sources for INTS4 Gene

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