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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

INTS4 Gene

protein-coding   GIFtS: 50
GCID: GC11M077589

Integrator Complex Subunit 4

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Integrator Complex Subunit 41 2
INT42
MST0932
MSTP0932
Int43

External Ids:    HGNC: 250481   Entrez Gene: 921052   Ensembl: ENSG000001492627   OMIM: 6113485   UniProtKB: Q96HW73   

Export aliases for INTS4 gene to outside databases

Previous GC identifers: GC11M077269 GC07P064459


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for INTS4 Gene:
INTS4 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II
large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM
180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 (PubMed 16239144)).(supplied by OMIM, Mar 2008)

GeneCards Summary for INTS4 Gene: 
INTS4 (integrator complex subunit 4) is a protein-coding gene. Diseases associated with INTS4 include down syndrome, and retinoblastoma. GO annotations related to this gene include protein binding.

UniProtKB/Swiss-Prot: INT4_HUMAN, Q96HW7
Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2
transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal
domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the INTS4 gene promoter:
         STAT5A   Tal-1beta   E4BP4   RORalpha2   MEF-2A   AREB6   POU2F1   POU2F1a   aMEF-2   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidINTS4 promoter sequence
   Search SABiosciences Chromatin IP Primers for INTS4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INTS4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q14.1   Ensembl cytogenetic band:  11q14.1   HGNC cytogenetic band: 11q14.1

INTS4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INTS4 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M077589:  view genomic region     (about GC identifiers)

Start:
77,589,766 bp from pter      End:
77,705,724 bp from pter
Size:
115,959 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: INT4_HUMAN, Q96HW7 (See protein sequence)
Recommended Name: Integrator complex subunit 4  
Size: 963 amino acids; 108171 Da
Subunit: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5,
INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12
Subcellular location: Nucleus (Probable)
Secondary accessions: Q2YD62 Q6PJG4 Q7Z4E7 Q96G32 Q96GA1 Q9BRC0
Alternative splicing: 4 isoforms:  Q96HW7-1   Q96HW7-2   Q96HW7-3   Q96HW7-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for INTS4: NX_Q96HW7

Explore proteomics data for INTS4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96HW7

  • INTS4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    INTS4 Protein Expression
    REFSEQ proteins: NP_291025.3  
    ENSEMBL proteins: 
     ENSP00000407787   ENSP00000434466   ENSP00000433644   ENSP00000432776   ENSP00000436248  
     ENSP00000435758   ENSP00000441084  

    Human Recombinant Protein Products for INTS4: 
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    Novus Biologicals INTS4 Protein
    Novus Biologicals INTS4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for INTS4 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032039integrator complex IDA16239144

    INTS4 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for INTS4 
    Cloud-Clone Corp. CLIAs for INTS4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR011989 ARM-like
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q96HW7

    ProtoNet protein and cluster: Q96HW7

    1 Blocks protein domain: IPB000357 HEAT repeat

    UniProtKB/Swiss-Prot: INT4_HUMAN, Q96HW7
    Similarity: Belongs to the Integrator subunit 4 family
    Similarity: Contains 8 HEAT repeats


    INTS4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: INT4_HUMAN, Q96HW7
    Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2
    transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal
    domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI16239144
         
    INTS4 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for INTS4:
     Increased circadian period len  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for INTS4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for INTS4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for INTS4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for INTS4 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat INTS4
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate INTS4:
    hsa-miR-125a-3p hsa-miR-513c hsa-miR-514b-5p
    SwitchGear 3'UTR luciferase reporter plasmidINTS4 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTS4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for INTS4

    5/6 Interacting proteins for INTS4 (Q96HW73) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    INTS1Q8N2013I2D: score=1 
    INTS3Q68E013I2D: score=1 
    INTS5Q6P9B93I2D: score=1 
    INTS6Q9UL033I2D: score=1 
    KIAA0513O602683I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016180snRNA processing IDA16239144

    INTS4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    INTS4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for INTS4 (INT4)

    10/45 Novoseek inferred chemical compound relationships for INTS4 gene (see all 45)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2-(hydroxymethyl)pyridine 83 1 16411688 (1)
    dimethyl acetylenedicarboxylate 71.7 2 19199302 (1)
    2,2'-bipyridine 67.5 2 18618562 (1), 20199051 (1)
    carborane 66.9 1 17712445 (1)
    acetonitrile 66 4 19489554 (1), 12425637 (1), 11196963 (1), 20025254 (1)
    2-methyltetrahydrofuran 64.8 1 16390078 (1)
    pyridine 61.4 1 19308980 (1)
    carboxylate 60.3 1 15252563 (1)
    tetrahydrofuran 58.1 1 16390078 (1)
    rhenium 57.7 1 11575768 (1)

    Search CenterWatch for drugs/clinical trials and news about INTS4 / INT4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for INTS4 gene: 
    NM_033547.3  

    Unigene Cluster for INTS4:

    Integrator complex subunit 4
    Hs.533723  [show with all ESTs]
    Unigene Representative Sequence: BC015664
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000433818(uc001oyt.3) ENST00000534064(uc001oys.3) ENST00000533180
    ENST00000525268 ENST00000531059 ENST00000525931 ENST00000529807(uc001oyu.1)
    ENST00000534408(uc001oyv.1) ENST00000524766 ENST00000527522 ENST00000535943


    miRNA
    Products:
         
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate INTS4:
    hsa-miR-125a-3p hsa-miR-513c hsa-miR-514b-5p
    SwitchGear 3'UTR luciferase reporter plasmidINTS4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for INTS4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat INTS4
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INTS4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INTS4

    Additional mRNA sequence: 

    AF172822.1 AK000455.1 AK096604.1 AK290866.1 AL834171.1 BC006369.1 BC008013.1 BC009859.2 
    BC009995.2 BC015664.2 BC018672.1 

    10 DOTS entries:

    DT.449744  DT.100784463  DT.91767154  DT.95376424  DT.120714327  DT.40237509  DT.86846922  DT.100661709 
    DT.40270646  DT.86857872 

    24/192 AceView cDNA sequences (see all 192):

    AI921466 AA708631 AA322631 BE207815 BX402388 BU170247 AA908729 BQ216049 
    AW467450 CA427438 BC015664 BC009995 T93283 BG271683 BM705496 BU844612 
    AK000455 AI002913 AI523929 C17892 BM972671 BM824605 BU932126 AA765511 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    INTS4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAGGTGGAA
    INTS4 Expression
    About this image


    See INTS4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for INTS4

    SOURCE GeneReport for Unigene cluster: Hs.533723
        SABiosciences Custom PCR Arrays for INTS4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTS4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for INTS4 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ints41 , 5 integrator complex subunit 41, 5 90.27(n)1
    96.88(a)1
      7 (53.52 cM)5
    1018611  NM_027256.21  NP_081532.11 
     974809565 
    chicken
    (Gallus gallus)
    Aves INTS41 integrator complex subunit 4 79.96(n)
    90.45(a)
      419028  XM_417220.3  XP_417220.3 
    lizard
    (Anolis carolinensis)
    Reptilia INTS46
    Uncharacterized protein
    87(a)
    1 ↔ 1
    GL343337.1(595295-628486)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.297292 Xenopus laevis transcribed sequences 76.1(n)    BJ039676.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ints41 integrator complex subunit 4 70.3(n)
    79.23(a)
      564681  XM_001923684.1  XP_001923719.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta IntS41 Integrator 4 47.59(n)
    38.78(a)
      31793  NM_132260.2  NP_572488.1 
    worm
    (Caenorhabditis elegans)
    Secernentea W04A4.51 Protein W04A4.5 41.78(n)
    29.01(a)
      173238  NM_060995.6  NP_493396.1 


    ENSEMBL Gene Tree for INTS4 (if available)
    TreeFam Gene Tree for INTS4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for INTS4 gene
    2 SIMAP similar genes for INTS4 using alignment to 3 protein entries:     INT4_HUMAN (see all proteins):
    INTS4L1    INTS4L2

    INTS4 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for INTS4
    PGOHUM00000232837 PGOHUM00000258280 PGOHUM00000260355 PGOHUM00000258281 PGOHUM00000260358


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2249 SNPs in INTS4 are shown (see all 2249)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs347675921,2
    C--77566332(+) AAAAA-/A/AA  
            
    TGTAT
    1 -- int11NA 2
    rs1827388931,2
    --77589352(+) GCAGTA/GAGCCA 1 -- ds50010--------
    rs1872642401,2
    --77589387(+) TGAGCA/GACACA 1 -- ds50010--------
    rs1917186871,2
    --77589391(+) CGACAA/CAGCAA 1 -- ds50010--------
    rs1173990701,2
    F--77589560(+) AAAAAA/GAAAGT 1 -- ds50011Minor allele frequency- G:0.02EA 120
    rs1846337171,2
    --77589580(+) AAAGCA/GGCCTT 1 -- ds50010--------
    rs729394391,2
    C--77589649(+) CAGTTA/GTCAGG 1 -- ds50015Minor allele frequency- G:0.18NA CSA WA EA 362
    rs1512093431,2
    --77589897(+) CCTTAA/GGCCTA 1 -- ut310--------
    rs1891494091,2
    --77589906(+) TACACA/GTCAAT 1 -- ut310--------
    rs1932560961,2
    --77589911(+) ATCAAC/TTCCAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for INTS4 (77589766 - 77705724 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for INTS4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv507601CNV Insertion20534489
    nsv400CNV Insertion18451855
    nsv8841CNV Loss18304495
    nsv524537CNV Loss19592680
    nsv526268CNV Gain19592680
    nsv520740CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing INTS4
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611348    OMIM disorders: --

    4 diseases for INTS4:    About MalaCards
    down syndrome    retinoblastoma    alzheimer's disease    alcoholism


    INTS4 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    1 Novoseek inferred disease relationship for INTS4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alzheimers disease 0 2 7748461 (1), 1321237 (1)

    Genetic Association Database (GAD): INTS4

    Export disorders for INTS4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for INTS4 gene, integrated from 9 sources (see all 167):
    (articles sorted by number of sources associating them with INTS4)
        Utopia: connect your pdf to the dynamic
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    1. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PubMed id 16239144)1, 2, 3 Baillat D....Shiekhattar R. (2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    5. The integrator complex is required for integrity of Ca jal bodies. (PubMed id 22250197)1 Takata H....Shibahara K. (2012)
    6. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    7. Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (2011)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. Streamlined analysis schema for high-throughput ident ification of endogenous protein complexes. (PubMed id 20133760)1 Malovannaya A....Qin J. (2010)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 92105 HGNC: 25048 AceView: MGC16733 Ensembl:ENSG00000149262 euGenes: HUgn92105
    ECgene: INTS4 H-InvDB: INTS4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for INTS4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for INTS4 gene:
    Search GeneIP for patents involving INTS4

    GeneCards and IP:
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