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Aliases for INTS3 Gene

Aliases for INTS3 Gene

  • Integrator Complex Subunit 3 2 3
  • Sensor Of Single-Strand DNA Complex Subunit A 2 3 4
  • Sensor Of SsDNA Subunit A 3 4
  • SOSS Complex Subunit A 3 4
  • C1orf193 3 4
  • C1orf60 3 4
  • SOSS-A 3 4
  • INT3 3 4
  • Chromosome 1 Open Reading Frame 60 2
  • Sensor Of SsDNA A 3
  • SOSSA 3

External Ids for INTS3 Gene

Previous HGNC Symbols for INTS3 Gene

  • C1orf60

Previous GeneCards Identifiers for INTS3 Gene

  • GC01P151967
  • GC01P153700
  • GC01P125063

Summaries for INTS3 Gene

Entrez Gene Summary for INTS3 Gene

  • INTS3 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]). INTS3 is also a subunit of single-stranded DNA (ssDNA)-binding complexes involved in the maintenance of genome stability (Huang et al., 2009) [PubMed 19683501].[supplied by OMIM, Feb 2010]

GeneCards Summary for INTS3 Gene

INTS3 (Integrator Complex Subunit 3) is a Protein Coding gene.

UniProtKB/Swiss-Prot for INTS3 Gene

  • Component of the Integrator complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes

  • Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. In the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites

Gene Wiki entry for INTS3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INTS3 Gene

Genomics for INTS3 Gene

Regulatory Elements for INTS3 Gene

Genomic Location for INTS3 Gene

Chromosome:
1
Start:
153,728,050 bp from pter
End:
153,774,808 bp from pter
Size:
46,759 bases
Orientation:
Plus strand

Genomic View for INTS3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for INTS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INTS3 Gene

Proteins for INTS3 Gene

  • Protein details for INTS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68E01-INT3_HUMAN
    Recommended name:
    Integrator complex subunit 3
    Protein Accession:
    Q68E01
    Secondary Accessions:
    • A8K1W0
    • B4DQC8
    • B4E3U9
    • D3DV57
    • Q4G0E5
    • Q5VUQ5
    • Q5VUQ6
    • Q5VUR0
    • Q5VUR1
    • Q68DJ1
    • Q69YR5
    • Q6AI57
    • Q6DKG7
    • Q6MZQ4
    • Q6MZZ9
    • Q8NC46
    • Q8TB23
    • Q9H6S9

    Protein attributes for INTS3 Gene

    Size:
    1043 amino acids
    Molecular mass:
    118070 Da
    Quaternary structure:
    • Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12. Component of the SOSS complex, composed of SOSS-B (SOSS-B1/NABP2 or SOSS-B2/NABP1), SOSS-A/INTS3 and SOSS-C/INIP. SOSS complexes containing SOSS-B1/NABP2 are more abundant than complexes containing SOSS-B2/NABP1. Interacts with SOSS-B1/NABP2, SOSS-B2/NABP1 and SOSS-C/INIP; the interaction is direct. Interacts with NBN/NBS1.
    SequenceCaution:
    • Sequence=AAH25254.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH54513.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15174.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11329.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH18229.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=CAH71415.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH71417.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH71418.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for INTS3 Gene

    Alternative splice isoforms for INTS3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for INTS3 Gene

Proteomics data for INTS3 Gene at MOPED

Post-translational modifications for INTS3 Gene

  • Ubiquitination at Lys 859, Lys 898, and Lys 915
  • Modification sites at PhosphoSitePlus

Other Protein References for INTS3 Gene

No data available for DME Specific Peptides for INTS3 Gene

Domains & Families for INTS3 Gene

Protein Domains for INTS3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for INTS3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q68E01

UniProtKB/Swiss-Prot:

INT3_HUMAN :
  • Belongs to the Integrator subunit 3 family.
Family:
  • Belongs to the Integrator subunit 3 family.
genes like me logo Genes that share domains with INTS3: view

No data available for Gene Families for INTS3 Gene

Function for INTS3 Gene

Molecular function for INTS3 Gene

UniProtKB/Swiss-Prot Function:
Component of the Integrator complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes
UniProtKB/Swiss-Prot Function:
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. In the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites

Gene Ontology (GO) - Molecular Function for INTS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16239144
genes like me logo Genes that share ontologies with INTS3: view

Phenotypes for INTS3 Gene

GenomeRNAi human phenotypes for INTS3:
genes like me logo Genes that share phenotypes with INTS3: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for INTS3 Gene

Localization for INTS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for INTS3 Gene

Nucleus. Note=Localizes to nuclear foci following DNA damage.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for INTS3 Gene COMPARTMENTS Subcellular localization image for INTS3 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for INTS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19683501
GO:0032039 integrator complex IDA 16239144
GO:0070876 SOSS complex IDA 18449195
genes like me logo Genes that share ontologies with INTS3: view

Pathways & Interactions for INTS3 Gene

SuperPathways for INTS3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for INTS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IMP 19605351
GO:0006974 cellular response to DNA damage stimulus IMP 19683501
GO:0007093 mitotic cell cycle checkpoint IMP 19683501
GO:0010212 response to ionizing radiation IMP 19605351
GO:0016180 snRNA processing IDA 16239144
genes like me logo Genes that share ontologies with INTS3: view

No data available for Pathways by source and SIGNOR curated interactions for INTS3 Gene

Drugs & Compounds for INTS3 Gene

(19) Drugs for INTS3 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2437
Ethanol Approved Pharma 1708
Iron Approved Pharma 957
Zinc Approved Pharma 1404
acetic acid Approved Nutra Full agonist, Agonist 80

(48) Additional Compounds for INTS3 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-(Hydroxymethyl)pyridine
2,2-BIPYRIDINE
4,4-bipyridine
Acetonitrile
  • ACETONITRILE
  • CH3-C#N
  • Cyanomethane
  • Ethanenitrile
  • MeCN
75-05-8
agcl
genes like me logo Genes that share compounds with INTS3: view

Transcripts for INTS3 Gene

Unigene Clusters for INTS3 Gene

Integrator complex subunit 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for INTS3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^
SP1: - - - - - - - - -
SP2:
SP3:
SP4: - - - -
SP5: -
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12:
SP13: -
SP14:
SP15:
SP16:

ExUns: 14 ^ 15a · 15b · 15c ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29 ^ 30
SP1:
SP2: - -
SP3: - -
SP4:
SP5:
SP6: -
SP7: -
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for INTS3 Gene

GeneLoc Exon Structure for
INTS3
ECgene alternative splicing isoforms for
INTS3

Expression for INTS3 Gene

mRNA expression in normal human tissues for INTS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for INTS3 Gene

This gene is overexpressed in Pancreas (10.6) and Peripheral blood mononuclear cells (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for INTS3 Gene



SOURCE GeneReport for Unigene cluster for INTS3 Gene Hs.516522

genes like me logo Genes that share expression patterns with INTS3: view

Protein tissue co-expression partners for INTS3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for INTS3 Gene

Orthologs for INTS3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for INTS3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia INTS3 35
  • 92.89 (n)
  • 99.4 (a)
INTS3 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia INTS3 35
  • 88.77 (n)
  • 94.98 (a)
INTS3 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ints3 35
  • 91.57 (n)
  • 98.91 (a)
Ints3 16
Ints3 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia INTS3 35
  • 99.84 (n)
  • 100 (a)
INTS3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ints3 35
  • 91.73 (n)
  • 98.81 (a)
oppossum
(Monodelphis domestica)
Mammalia INTS3 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia INTS3 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves INTS3 35
  • 81 (n)
  • 95.2 (a)
INTS3 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia INTS3 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11354 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.15160 35
zebrafish
(Danio rerio)
Actinopterygii Dr.15113 35
ints3 35
  • 76.09 (n)
  • 85.77 (a)
ints3 36
  • 85 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta INT3_ANOGA 35
  • 53.32 (n)
  • 43.62 (a)
fruit fly
(Drosophila melanogaster)
Insecta IntS3 35
  • 50.94 (n)
  • 44.87 (a)
IntS3 36
  • 38 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y92H12A.4 35
  • 39.89 (n)
  • 25.88 (a)
Y92H12A.3 36
  • 28 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons emb2739 35
  • 48.11 (n)
  • 35.68 (a)
rice
(Oryza sativa)
Liliopsida Os11g0171400 35
  • 51.16 (n)
  • 41.4 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
OneToOne
Species with no ortholog for INTS3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for INTS3 Gene

ENSEMBL:
Gene Tree for INTS3 (if available)
TreeFam:
Gene Tree for INTS3 (if available)

Paralogs for INTS3 Gene

No data available for Paralogs for INTS3 Gene

Variants for INTS3 Gene

Sequence variations from dbSNP and Humsavar for INTS3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs3814002 -- 153,763,181(-) CAACA(A/G)AGACA intron-variant
rs3842687 -- 153,764,235(-) GAGGG(-/GG)AAAAT intron-variant
rs4073768 -- 153,755,156(+) CAGAC(C/T)TGACT intron-variant
rs4345834 -- 153,770,841(+) CTGTC(A/G)TTAAC intron-variant
rs4375302 -- 153,753,556(+) gtccc(A/C)aaaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for INTS3 Gene

Variant ID Type Subtype PubMed ID
nsv464028 CNV Gain 19166990

Variation tolerance for INTS3 Gene

Residual Variation Intolerance Score: 1.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.85; 17.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for INTS3 Gene

HapMap Linkage Disequilibrium report
INTS3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INTS3 Gene

Disorders for INTS3 Gene

Relevant External Links for INTS3

Genetic Association Database (GAD)
INTS3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
INTS3
genes like me logo Genes that share disorders with INTS3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for INTS3 Gene

Publications for INTS3 Gene

  1. Functionalized 1,2,3-triazoles as building blocks for photoluminescent POLOs (polymers of oligomers) of copper(I). (PMID: 20179857) Bai S.Q. … Hor T.S. (Dalton Trans 2010) 23 67
  2. Synthesis and characterization of a tin(II) bis(phosphinoyl)methanediide complex: a stannavinylidene derivative. (PMID: 20198256) Guo J. … So C.W. (Chem. Commun. (Camb.) 2010) 23 67
  3. Community exposure following a drip-application of chloropicrin. (PMID: 20390729) Barry T. … O'Malley M. (J Agromedicine 2010) 23 67
  4. Tetrahedral and square planar Ni[(SPR(2))(2)N](2) complexes, R = Ph & (i)Pr revisited: experimental and theoretical analysis of interconversion pathways, structural preferences, and spin delocalization. (PMID: 20462270) Maganas D. … Neese F. (Inorg Chem 2010) 23 67
  5. ESI-MS studies of palladium (II) complexes with 1-(p-toluenesulfonyl)cytosine/cytosinato ligands. (PMID: 19882593) KobetiA8 R. … Gabelica-MarkoviA8 V. (J Mass Spectrom 2010) 23 67

Products for INTS3 Gene

Sources for INTS3 Gene

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