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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

INTS3 Gene

protein-coding   GIFtS: 49
GCID: GC01P153700

Integrator Complex Subunit 3

(Previous name: chromosome 1 open reading frame 60)
(Previous symbol: C1orf60)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Integrator Complex Subunit 31 2     SOSS Complex Subunit A2 3
C1orf601 2 3     Chromosome 1 Open Reading Frame 601
Sensor Of Single-Strand DNA Complex Subunit A1 2 3     INT32
Sensor Of SsDNA Subunit A2 3     RP11-216N14.42
C1orf1932 3     Sensor Of SsDNA A2
SOSS-A2 3     Int33

External Ids:    HGNC: 261531   Entrez Gene: 651232   Ensembl: ENSG000001436247   OMIM: 6113475   UniProtKB: Q68E013   

Export aliases for INTS3 gene to outside databases

Previous GC identifers: GC01P151967 GC01P125063


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for INTS3 Gene:
INTS3 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II
large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM
180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 (PubMed 16239144)). INTS3 is also a subunit of
single-stranded DNA (ssDNA)-binding complexes involved in the maintenance of genome stability (Huang et al.,
2009) (PubMed 19683501).(supplied by OMIM, Feb 2010)

GeneCards Summary for INTS3 Gene: 
INTS3 (integrator complex subunit 3) is a protein-coding gene. Diseases associated with INTS3 include trigonitis, and epilepsies, partial. GO annotations related to this gene include protein binding.

UniProtKB/Swiss-Prot: INT3_HUMAN, Q68E01
Function: Component of the Integrator complex. The Integrator complex is involved in the small nuclear RNAs
(snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated
with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2
snRNAs genes
Function: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to
promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and
influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation,
recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient
homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. In
the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA
damage sites

Gene Wiki entry for INTS3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the INTS3 gene promoter:
         GR   E2F-4   E2F-3a   E2F-5   GR-beta   CUTL1   E2F-2   E2F   E2F-1   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidINTS3 promoter sequence
   Search SABiosciences Chromatin IP Primers for INTS3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INTS3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21.3

INTS3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INTS3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P153700:  view genomic region     (about GC identifiers)

Start:
153,700,543 bp from pter      End:
153,746,555 bp from pter
Size:
46,013 bases      Orientation:
plus strand

1 alternative location:
Chr1+,NW_003315905 44,792-90,780     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: INT3_HUMAN, Q68E01 (See protein sequence)
Recommended Name: Integrator complex subunit 3  
Size: 1043 amino acids; 118070 Da
Subunit: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5,
INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12. Component of the SOSS complex, composed of
SOSS-B (SOSS-B1/NABP2 or SOSS-B2/NABP1), SOSS-A/INTS3 and SOSS-C/INIP. SOSS complexes containing SOSS-B1/NABP2
are more abundant than complexes containing SOSS-B2/NABP1. Interacts with SOSS-B1/NABP2, SOSS-B2/NABP1 and
SOSS-C/INIP; the interaction is direct. Interacts with NBN/NBS1
Subcellular location: Nucleus. Note=Localizes to nuclear foci following DNA damage
Sequence caution: Sequence=AAH25254.1; Type=Erroneous initiation; Sequence=AAH54513.1; Type=Erroneous initiation;
Sequence=BAB15174.1; Type=Erroneous initiation; Sequence=BAC11329.1; Type=Erroneous initiation;
Sequence=CAH18229.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=CAH71415.1; Type=Erroneous
gene model prediction; Sequence=CAH71417.1; Type=Erroneous gene model prediction; Sequence=CAH71418.1;
Type=Erroneous gene model prediction;
Secondary accessions: A8K1W0 B4DQC8 B4E3U9 D3DV57 Q4G0E5 Q5VUQ5 Q5VUQ6 Q5VUR0 Q5VUR1 Q68DJ1
Q69YR5 Q6AI57 Q6DKG7 Q6MZQ4 Q6MZZ9 Q8NC46 Q8TB23 Q9H6S9
Alternative splicing: 4 isoforms:  Q68E01-1   Q68E01-2   Q68E01-3   Q68E01-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for INTS3: NX_Q68E01

Explore proteomics data for INTS3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q68E01

  • INTS3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    INTS3 Protein Expression
    REFSEQ proteins: NP_075391.3  
    ENSEMBL proteins: 
     ENSP00000318641   ENSP00000404290   ENSP00000425437   ENSP00000422616   ENSP00000398222  

    Human Recombinant Protein Products for INTS3: 
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    OriGene Custom MassSpec 
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    Novus Biologicals INTS3 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for INTS3 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA19683501
    GO:0032039integrator complex IDA16239144
    GO:0070876SOSS complex IDA18449195

    INTS3 for ontologies           About GeneDecksing



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    Novus Biologicals INTS3 Antibodies
    Abcam antibodies for INTS3
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    Search ThermoFisher Antibodies for INTS3
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    Assay Products for INTS3: 
    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for INTS3 
    Cloud-Clone Corp. CLIAs for INTS3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR019333 Int_cplx_su3

    Graphical View of Domain Structure for InterPro Entry Q68E01

    ProtoNet protein and cluster: Q68E01

    UniProtKB/Swiss-Prot: INT3_HUMAN, Q68E01
    Similarity: Belongs to the Integrator subunit 3 family


    INTS3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: INT3_HUMAN, Q68E01
    Function: Component of the Integrator complex. The Integrator complex is involved in the small nuclear RNAs
    (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated
    with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2
    snRNAs genes
    Function: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to
    promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and
    influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation,
    recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient
    homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. In
    the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA
    damage sites

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16239144
         
    INTS3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for INTS3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for INTS3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for INTS3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for INTS3 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat INTS3
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate INTS3 (see all 10):
    hsa-miR-548d-3p hsa-miR-548am hsa-miR-185* hsa-miR-455-3p hsa-miR-149 hsa-miR-548x hsa-miR-608 hsa-miR-3616-3p
    SwitchGear 3'UTR luciferase reporter plasmidINTS3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for INTS3
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    Gene Editing
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    Clone
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    Sino Biological Human cDNA Clone for INTS3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INTS3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INTS3
    Sirion Biotech Customized lentivirus for stable overexpression of INTS3 
                         Customized lentivirus expression plasmids for stable overexpression of INTS3 

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTS3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for INTS3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/810 Interacting proteins for INTS3 (Q68E012, 3 ENSP000003186414) via UniProtKB, MINT, STRING, and/or I2D (see all 810)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP2R1AP301532, 3, ENSP000003248044MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000324804
    INTS6Q9UL032, 3, ENSP000003102604MINT-7947479 I2D: score=1 STRING: ENSP00000310260
    INTS8Q75QN22, 3, ENSP000003432744MINT-7947479 I2D: score=1 STRING: ENSP00000343274
    POLR2EP193882, 3, ENSP000002155874MINT-7945693 I2D: score=1 STRING: ENSP00000215587
    INTS12Q96CB82, 3MINT-7945693 I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000075cell cycle checkpoint ----
    GO:0006281DNA repair IMP19605351
    GO:0006974response to DNA damage stimulus IMP19683501
    GO:0007093mitotic cell cycle checkpoint IMP19683501
    GO:0010212response to ionizing radiation IMP19605351

    INTS3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    INTS3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for INTS3 (INT3)

    10/67 Novoseek inferred chemical compound relationships for INTS3 gene (see all 67)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2-(hydroxymethyl)pyridine 89.7 1 16411688 (1)
    dppz 80.3 2 19050783 (1)
    2,2'-bipyridine 79.2 5 15934758 (1), 15149244 (1), 16363818 (1), 20199051 (1)
    acetonitrile 71.6 7 18648705 (1), 18841928 (1), 12184772 (1), 17173448 (1) (see all 7)
    1,10-phenanthroline 71.6 5 15356721 (1), 19254037 (1), 15149244 (1), 17058961 (1)
    carboxylate 68.2 6 11187465 (1), 17387398 (1), 17988122 (1), 16676952 (1) (see all 5)
    copper(i) 68.1 3 16097834 (1), 12691587 (1)
    pyridine 66.1 5 18648705 (1), 18975873 (1), 18844344 (1), 19234747 (1)
    dicyanamide 64.7 1 20141179 (1)
    hydride 63.1 5 18060114 (1), 20000856 (1), 17563789 (1), 11724599 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about INTS3 / INT3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for INTS3 gene: 
    NM_023015.3  

    Unigene Cluster for INTS3:

    Integrator complex subunit 3
    Hs.516522  [show with all ESTs]
    Unigene Representative Sequence: CR749376
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000318967(uc009wom.3 uc001fct.3) ENST00000435409 ENST00000481797(uc001fcu.3 uc001fcv.3)
    ENST00000512605 ENST00000476843(uc001fcw.3 uc010pec.2) ENST00000480659
    ENST00000503133 ENST00000491790 ENST00000368670(uc001fcx.3 uc001fcy.3)
    ENST00000368669 ENST00000456435(uc010peb.2)
    miRNA
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    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate INTS3 (see all 10):
    hsa-miR-548d-3p hsa-miR-548am hsa-miR-185* hsa-miR-455-3p hsa-miR-149 hsa-miR-548x hsa-miR-608 hsa-miR-3616-3p
    SwitchGear 3'UTR luciferase reporter plasmidINTS3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat INTS3
    Clone
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    OriGene clones in human, mouse for INTS3 (see all 6)
    OriGene ORF clones in mouse, rat for INTS3
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    GenScript: all cDNA clones in your preferred vector: INTS3 (NM_023015)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INTS3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INTS3
    Sirion Biotech Customized lentivirus for stable overexpression of INTS3 
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INTS3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INTS3

    Additional mRNA sequence: 

    AF130066.2 AK025572.1 AK055174.1 AK074979.1 AK091908.1 AK094402.1 AK126799.1 AK225294.1 
    AK290025.1 AK298746.1 AK304874.1 AL080172.1 AL832133.1 BC025254.1 BC054513.1 BC073985.1 
    BC098431.1 BC105092.1 BC105094.1 BC116458.1 BX640786.1 BX640950.1 CR627233.1 CR749212.1 
    CR749376.1 

    21 DOTS entries:

    DT.100713671  DT.95236436  DT.75173419  DT.91888334  DT.447918  DT.97791520  DT.100028537  DT.101983862 
    DT.121390581  DT.75155374  DT.100791259  DT.99932903  DT.101983861  DT.121390718  DT.92444285  DT.92444288 
    DT.121390725  DT.40248431  DT.91968365  DT.100811416  DT.95076529 

    24/393 AceView cDNA sequences (see all 393):

    BI820997 BC025254 BQ721318 BU552491 AK075377 BC073985 BC003041 BC029792 
    BM678297 BU145596 BG258327 BC009916 CA389249 BE397184 BM014385 CB156492 
    AW245381 BM722770 BP367886 BM473894 BG678348 BU542713 AL080172 NM_024330 

    GeneLoc Exon Structure

    5/16 Alternative Splicing Database (ASD) splice patterns (SP) for INTS3 (see all 16)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^
    SP1:                                      -                 -     -                       -     -     -     -     -     -                                       
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                      -                 -     -                                   -                                                         
    SP5:                                                                                                  -                                                         

    ExUns: 14 ^ 15a · 15b · 15c ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29 ^ 30
    SP1:                                                                                                                                          
    SP2:                                                                                      -           -                                       
    SP3:                                                                                      -           -                                       
    SP4:                                                                                                                                          
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for INTS3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    INTS3 expression in normal human tissues (normalized intensities)      INTS3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGCAGATGC
    INTS3 Expression
    About this image


    INTS3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Testis (Reproductive System)
             Testis Somatic Cells Primitive Gonad
     
     Kidney (Urinary System)
             renal vesicle e12.5   
     
     Gonad (Reproductive System)
             Testis Somatic Cells Primitive Gonad
     
     Oral Cavity (Gastrointestinal Tract)
             TONGUE   
     
     Larynx (Respiratory System)

    See INTS3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for INTS3

    SOURCE GeneReport for Unigene cluster: Hs.516522
        SABiosciences Custom PCR Arrays for INTS3
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for INTS3 gene from 9/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ints31 , 5 integrator complex subunit 31, 5 91.55(n)1
    98.75(a)1
      3 (39.22 cM)5
    2295431  NM_178876.31  NP_849207.21 
     903913805 
    chicken
    (Gallus gallus)
    Aves INTS31 integrator complex subunit 3 77.08(n)
    89.33(a)
      771890  XM_001235107.2  XP_001235108.2 
    lizard
    (Anolis carolinensis)
    Reptilia INTS36
    Uncharacterized protein
    92(a)
    1 ↔ 1
    AAWZ02040536(1804-6713)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.151602 Xenopus laevis transcribed sequence with moderate similarity more 83(n)    BX851918.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.151132 Transcribed sequences 74.19(n)    57066757 
    fruit fly
    (Drosophila melanogaster)
    Insecta IntS31 Integrator 3 48.66(n)
    40.58(a)
      3355010  NM_001042972.1  NP_001036437.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y92H12A.41 Protein Y92H12A.4 39.27(n)
    24.76(a)
      3565441  NM_058462.3  NP_490863.3 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons emb27391 integrator complex subunit 3 47.97(n)
    35.23(a)
      827107  NM_117539.1  NP_193195.1 
    rice
    (Oryza sativa)
    Liliopsida AK107165.12   -- 72.6(n)    AK107165.1 


    ENSEMBL Gene Tree for INTS3 (if available)
    TreeFam Gene Tree for INTS3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/923 SNPs in INTS3 are shown (see all 923)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs730137321,2
    C,F--153698580(+) ATTGCC/TTGTAG 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs569108711,2
    C,F--153698703(+) GTAAAA/CCAAGC 1 -- us2k16Minor allele frequency- C:0.26WA NA 246
    rs1114920881,2
    C,F--153698874(+) AGCGAA/GATTTG 1 -- us2k12Minor allele frequency- G:0.08NA 122
    rs730137341,2
    C,F--153698935(+) GACGGG/ACGTAT 1 -- us2k12Minor allele frequency- A:0.03WA 120
    rs618035651,2
    C,F--153699201(+) ACCGGG/ACGTGG 1 -- us2k14Minor allele frequency- A:0.13NA WA 242
    rs618035661,2
    C,F--153699235(+) TACTCG/AGGAGG 1 -- us2k13Minor allele frequency- A:0.50NA WA 6
    rs762182281,2
    C--153699268(+) ACCCGG/TGAGGT 1 -- us2k10--------
    rs1484038631,2
    C--153699445(+) ACACAG/TATGGA 1 -- us2k10--------
    rs1416611331,2
    --153699530(+) TGGGTA/GAAAGT 1 -- us2k10--------
    rs1120571691,2
    C--153699555(+) CCAGAC/TACTCA 1 -- us2k11Minor allele frequency- T:0.50CSA 2

    HapMap Linkage Disequilibrium report for INTS3 (153700543 - 153746555 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for INTS3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv464028CNV Gain19166990

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611347    OMIM disorders: --

    9 diseases for INTS3:    About MalaCards
    trigonitis    epilepsies, partial    respiratory failure    vaginitis
    myopathy    alcoholism    diabetes mellitus    hypertension
    hepatocellular carcinoma


    INTS3 for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for INTS3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 1.34 1 17459058 (1)
    tumors 0.443 3 18068530 (1), 19926362 (1), 16763798 (1)
    fistula 0 4 11948570 (1), 18392245 (1), 12695831 (1), 17586004 (1)
    epilepsies partial 0 1 1637133 (1)
    cancer 0 3 18350297 (1), 20102782 (1)

    Genetic Association Database (GAD): INTS3

    Export disorders for INTS3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for INTS3 gene, integrated from 9 sources (see all 247):
    (articles sorted by number of sources associating them with INTS3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PubMed id 16239144)1, 2, 3 Baillat D....Shiekhattar R. (2005)
    2. hSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response. (PubMed id 19605351)1, 2 Li Y.... Wang W. (2009)
    3. SOSS complexes participate in the maintenance of genomic stability. (PubMed id 19683501)1, 2 Huang J.... Chen J. (2009)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 65123 HGNC: 26153 AceView: FLJ21919andSLC27A3 Ensembl:ENSG00000143624 euGenes: HUgn65123
    ECgene: INTS3 H-InvDB: INTS3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for INTS3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for INTS3 gene:
    Search GeneIP for patents involving INTS3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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