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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

INTS2 Gene

protein-coding   GIFtS: 49
GCID: GC17M059942

Integrator Complex Subunit 2

(Previous name: KIAA1287)
(Previous symbol: KIAA1287)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Integrator Complex Subunit 21 2
KIAA12871 2 3
INT22
Int23

External Ids:    HGNC: 292411   Entrez Gene: 575082   Ensembl: ENSG000001085067   OMIM: 6113465   UniProtKB: Q9H0H03   
ORGUL members:         
NONCODE14:n407180      

Export aliases for INTS2 gene to outside databases

Previous GC identifers: GC17M057298 GC17M055308


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for INTS2 Gene:
INTS2 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II
large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM
180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 (PubMed 16239144)).(supplied by OMIM, Mar 2008)

GeneCards Summary for INTS2 Gene: 
INTS2 (integrator complex subunit 2) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with INTS2 include appendicitis, and tuberous sclerosis. GO annotations related to this gene include protein binding.

UniProtKB/Swiss-Prot: INT2_HUMAN, Q9H0H0
Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2
transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal
domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the INTS2 gene promoter:
         C/EBPbeta   STAT1   STAT4   STAT1beta   E47   STAT1alpha   POU2F1   POU2F1a   STAT2   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidINTS2 promoter sequence
   Search SABiosciences Chromatin IP Primers for INTS2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INTS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.2   Ensembl cytogenetic band:  17q23.2   HGNC cytogenetic band: 17q23.2

INTS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INTS2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M059942:  view genomic region     (about GC identifiers)

Start:
59,942,728 bp from pter      End:
60,005,377 bp from pter
Size:
62,650 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: INT2_HUMAN, Q9H0H0 (See protein sequence)
Recommended Name: Integrator complex subunit 2  
Size: 1204 amino acids; 134323 Da
Subunit: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5,
INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12
Subcellular location: Nucleus membrane; Single-pass membrane protein (Potential)
Caution: It is uncertain whether Met-1 or Met-9 is the initiator. Orthologous sequences (mouse and chicken) have
shorter N-terminus
Secondary accessions: Q9ULD3

Explore the universe of human proteins at neXtProt for INTS2: NX_Q9H0H0

Explore proteomics data for INTS2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H0H0

  • INTS2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    INTS2 Protein Expression
    REFSEQ proteins: NP_065799.1  
    ENSEMBL proteins: 
     ENSP00000414237   ENSP00000251334   ENSP00000461996  

    Human Recombinant Protein Products for INTS2: 
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    OriGene Protein Over-expression Lysate for INTS2
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for INTS2 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--
    GO:0016021integral to membrane IEA--
    GO:0031965nuclear membrane IEA--
    GO:0032039integrator complex IDA16239144

    INTS2 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for INTS2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR026236 Int2

    Graphical View of Domain Structure for InterPro Entry Q9H0H0

    ProtoNet protein and cluster: Q9H0H0

    UniProtKB/Swiss-Prot: INT2_HUMAN, Q9H0H0
    Similarity: Belongs to the Integrator subunit 2 family


    INTS2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: INT2_HUMAN, Q9H0H0
    Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2
    transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal
    domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16239144
         
    INTS2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for INTS2:
     Increased circadian period len  Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Ints2):
     mortality/aging 

    INTS2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for INTS2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for INTS2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for INTS2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for INTS2 

    miRNA
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    8/71 QIAGEN miScript miRNA Assays for microRNAs that regulate INTS2 (see all 71):
    hsa-miR-548j hsa-miR-640 hsa-miR-3607-3p hsa-miR-4272 hsa-miR-30d hsa-miR-10b* hsa-miR-30a hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidINTS2 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTS2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for INTS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/14 Interacting proteins for INTS2 (Q9H0H03 ENSP000004142374) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    INTS5Q6P9B93, ENSP000003278894I2D: score=1 STRING: ENSP00000327889
    INTS1Q8N2013, ENSP000003857224I2D: score=1 STRING: ENSP00000385722
    INTS3Q68E013, ENSP000003186414I2D: score=1 STRING: ENSP00000318641
    INTS6Q9UL033, ENSP000003102604I2D: score=1 STRING: ENSP00000310260
    CPSF3LENSP000004134934STRING: ENSP00000413493
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016180snRNA processing IDA16239144

    INTS2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    INTS2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for INTS2 (INT2)

    10/83 Novoseek inferred chemical compound relationships for INTS2 gene (see all 83)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2-(hydroxymethyl)pyridine 88.3 1 16411688 (1)
    2,2'-bipyridine 77.8 3 16363818 (1), 20199051 (1), 16241145 (1)
    3,3-dimethyl-1-butanol 72.2 1 16411688 (1)
    4,4'-bipyridine 70.8 2 15252617 (1)
    trans-1,2-bis(4-pyridyl)ethylene 70.8 2 15252617 (1)
    copper(i) 69.7 3 16878922 (1), 18253464 (1), 14632530 (1)
    acetonitrile 68.9 15 18187198 (2), 18275066 (1), 19006294 (1), 15236555 (1) (see all 13)
    pyridine 68.2 8 19452073 (1), 16602768 (1), 17317290 (1), 2396015 (1) (see all 6)
    1,10-phenanthroline 67.2 4 19132936 (1), 19086049 (1), 16406550 (1), 18629409 (1)
    oxo 67.1 3 17566134 (1), 15554634 (1), 10499102 (1)

    Search CenterWatch for drugs/clinical trials and news about INTS2 / INT2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for INTS2 gene: 
    NM_020748.2  

    Unigene Cluster for INTS2:

    Integrator complex subunit 2
    Hs.279646  [show with all ESTs]
    Unigene Representative Sequence: NR_026641
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000444766(uc002izm.3 uc002izn.3) ENST00000251334 ENST00000583822
    ENST00000584967 ENST00000578805 ENST00000583076
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/71 QIAGEN miScript miRNA Assays for microRNAs that regulate INTS2 (see all 71):
    hsa-miR-548j hsa-miR-640 hsa-miR-3607-3p hsa-miR-4272 hsa-miR-30d hsa-miR-10b* hsa-miR-30a hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidINTS2 3' UTR sequence
    Inhib. RNA
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat INTS2
    Clone
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INTS2
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat INTS2
    Sirion Biotech Customized lentivirus for stable overexpression of INTS2 
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INTS2

    Additional mRNA sequence: 

    AK308307.1 AL136800.1 CR533582.1 NR_026641.1 

    8 DOTS entries:

    DT.108729  DT.91946501  DT.75125078  DT.120905689  DT.120905693  DT.100647275  DT.40196972  DT.97772673 

    24/38 AceView cDNA sequences (see all 38):

    AB033113 AA665115 AA745269 BP361236 AW089398 AL136800 CR533582 NM_020748 
    BX098692 BX395093 BQ286160 AI873609 CD654771 CA488094 BU190134 BG060032 
    BP356796 BU607369 BG258230 CD655209 BM469099 BX349974 BI755440 W00376 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for INTS2 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a ·
    SP1:                                                                                                                          -                             -   
    SP2:                          -     -                                                                                                                           
    SP3:                    -     -     -                                                                                                                           
    SP4:                                                                                                                                                            
    SP5:                                -                                                                                                                           

    ExUns: 17b ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25
    SP1:                                                            
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for INTS2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    INTS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTTTAAGT
    INTS2 Expression
    About this image


    See INTS2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for INTS2

    SOURCE GeneReport for Unigene cluster: Hs.279646
        SABiosciences Custom PCR Arrays for INTS2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for INTS2 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ints21 , 5 integrator complex subunit 21, 5 88.92(n)1
    96.23(a)1
      11 (51.71 cM)5
    704221  NM_027421.21  NP_081697.21 
     862106815 
    chicken
    (Gallus gallus)
    Aves INTS21 integrator complex subunit 2 79.83(n)
    91.34(a)
      417640  NM_001030722.1  NP_001025893.1 
    lizard
    (Anolis carolinensis)
    Reptilia INTS26
    Uncharacterized protein
    91(a)
    1 ↔ 1
    GL343470.1(931-12107)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ032170.12   -- 78.43(n)    BJ032170.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BI867948.12   -- 70.3(n)    BI867948.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta IntS21 Integrator 2 48.82(n)
    41.92(a)
      32745  NM_133004.1  NP_573232.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ZC376.66
    Protein ZC376.6, isoform b
    17(a)
    1 ↔ 1
    V(14185785-14192158)


    ENSEMBL Gene Tree for INTS2 (if available)
    TreeFam Gene Tree for INTS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1263 SNPs in INTS2 are shown (see all 1263)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs557518691,2
    C--55344748(+) TTTTT-/T/TT  
     TTTTTTT
    CTGAG
    2 -- int11NA 2
    rs743830271,2
    C--59943068(+) AGTTT-/AAAAAA 2 -- nc-transcript-variantut310--------
    rs72134691,2
    C,F,A,H--59943288(+) TCATTC/TTCATA 2 -- nc-transcript-variantut3112Minor allele frequency- T:0.09NS EA NA WA 1310
    rs72150761,2
    C,F,A,H--59943532(+) ACCAGT/CCTGGG 2 -- nc-transcript-variantut31 ese37Minor allele frequency- C:0.34NA WA CSA 130
    rs116499391,2
    C,H--59943559(+) CGTCTC/TTACTA 2 -- nc-transcript-variantut31 ese310Minor allele frequency- T:0.01NA WA CSA EA 136
    rs1829271661,2
    --59943589(+) GGCGCA/GTGCCT 2 -- nc-transcript-variantut310--------
    rs96307351,2
    C,A--59943704(+) CAGGGG/CAAGAC 2 -- nc-transcript-variantut31 ese35Minor allele frequency- C:0.22NA WA EA 362
    rs1116294581,2
    C--59943707(+) GGGAAA/GACTCC 2 -- nc-transcript-variantut310--------
    rs1150768261,2
    F--59943914(+) CCTTCG/AGCAAG 2 -- nc-transcript-variantut311Minor allele frequency- A:0.01WA 118
    rs1872642621,2
    --59944341(+) GCTACC/TTGCCT 2 -- nc-transcript-variantut310--------

    HapMap Linkage Disequilibrium report for INTS2 (59942728 - 60005377 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for INTS2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2673812CNV Deletion23128226
    esv269932CNV Insertion20981092

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611346    OMIM disorders: --

    14 diseases for INTS2:    About MalaCards
    appendicitis    tuberous sclerosis    abdominal aortic aneurysm    temporal lobe epilepsy
    aortic aneurysm    acute promyelocytic leukemia    meningitis    acute leukemia
    cytochrome p450    alcoholism    hypoxia    cerebritis
    leukemia    breast cancer


    INTS2 for disorders           About GeneDecksing

    8 Novoseek inferred disease relationships for INTS2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    complex partial seizures 12 3 10390770 (1), 11022139 (1), 10768157 (1)
    oncocytoma 6.27 2 7631937 (1), 1721653 (1)
    tuberous sclerosis 2.62 3 16648488 (1), 15466161 (1), 16816403 (1)
    cervical cancer 0 1 19258961 (1)
    reflux 0 1 18844344 (1)
    tumors 0 7 15927264 (1), 16816403 (1), 19258506 (1), 1721653 (1) (see all 7)
    cancer 0 5 17542650 (1), 19258506 (1), 19860841 (1), 20023900 (1) (see all 5)
    cysts 0 3 7631937 (1), 1721653 (1), 7945904 (1)


    Export disorders for INTS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for INTS2 gene, integrated from 9 sources (see all 327):
    (articles sorted by number of sources associating them with INTS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PubMed id 16239144)1, 2, 3 Baillat D....Shiekhattar R. (2005)
    2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    3. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2 Nagase T.... Ohara O. (1999)
    4. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (2013)
    5. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (2013)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    8. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    9. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57508 HGNC: 29241 AceView: KIAA1287 Ensembl:ENSG00000108506 euGenes: HUgn57508
    ECgene: INTS2 H-InvDB: INTS2

    (According to HUGE)
    About This Section
    HUGE: KIAA1287

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for INTS2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for INTS2 gene:
    Search GeneIP for patents involving INTS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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