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INTS2 Gene

protein-coding   GIFtS: 50
GCID: GC17M059942

Integrator Complex Subunit 2

(Previous name: KIAA1287)
(Previous symbol: KIAA1287)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Integrator Complex Subunit 21 2
KIAA12871 2 3 5
INT22 5
Int23

External Ids:    HGNC: 292411   Entrez Gene: 575082   Ensembl: ENSG000001085067   OMIM: 6113465   UniProtKB: Q9H0H03   

Export aliases for INTS2 gene to outside databases

Previous GC identifers: GC17M057298 GC17M055308


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for INTS2 Gene:
INTS2 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II
large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM
180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 (PubMed 16239144)).(supplied by OMIM, Mar 2008)

GeneCards Summary for INTS2 Gene:
INTS2 (integrator complex subunit 2) is a protein-coding gene.

UniProtKB/Swiss-Prot: INT2_HUMAN, Q9H0H0
Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2
transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal
domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the INTS2 gene promoter:
         C/EBPbeta   STAT1   STAT4   STAT1beta   E47   STAT1alpha   POU2F1   POU2F1a   STAT2   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidINTS2 promoter sequence
   Search Chromatin IP Primers for INTS2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat INTS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.2   Ensembl cytogenetic band:  17q23.2   HGNC cytogenetic band: 17q23.2

INTS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INTS2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M059942:  view genomic region     (about GC identifiers)

Start:
59,942,728 bp from pter      End:
60,005,377 bp from pter
Size:
62,650 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: INT2_HUMAN, Q9H0H0 (See protein sequence)
Recommended Name: Integrator complex subunit 2  
Size: 1204 amino acids; 134323 Da
Subunit: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5,
INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12
Caution: It is uncertain whether Met-1 or Met-9 is the initiator. Orthologous sequences (mouse and chicken) have
shorter N-terminus
Secondary accessions: Q9ULD3

Explore the universe of human proteins at neXtProt for INTS2: NX_Q9H0H0

Explore proteomics data for INTS2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys108, Lys255, Lys263, Lys1156
  • Modification sites at PhosphoSitePlus

  • See INTS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065799.1  
    ENSEMBL proteins: 
     ENSP00000414237   ENSP00000251334   ENSP00000461996  

    INTS2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for INTS2

     
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    Search antibodies-online for proteins for INTS2 

     
    Search antibodies-online for peptides for INTS2

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    antibodies-online antibodies for INTS2 (9 products) 

    INTS2 Assay Products:

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    Cloud-Clone Corp. ELISAs for INTS2
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    antibodies-online kits for INTS2 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026236 Int2

    Graphical View of Domain Structure for InterPro Entry Q9H0H0

    ProtoNet protein and cluster: Q9H0H0

    UniProtKB/Swiss-Prot: INT2_HUMAN, Q9H0H0
    Similarity: Belongs to the Integrator subunit 2 family


    Find genes that share domains with INTS2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: INT2_HUMAN, Q9H0H0
    Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2
    transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal
    domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16239144
         
    Find genes that share ontologies with INTS2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for INTS2:
     Increased circadian period len  Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Ints2):
     mortality/aging 

    Find genes that share phenotypes with INTS2           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for INTS2

    miRNA
    Products:
        
    miRTarBase miRNAs that target INTS2:
    hsa-mir-10a-5p (MIRT047608), hsa-mir-28-3p (MIRT038945), hsa-mir-128-3p (MIRT021883)

    Block miRNA regulation of human, mouse, rat INTS2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate INTS2 (see all 71):
    hsa-miR-548j hsa-miR-640 hsa-miR-3607-3p hsa-miR-4272 hsa-miR-30d hsa-miR-10b* hsa-miR-30a hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidINTS2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat INTS2

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: INTS2 (NM_020748)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INTS2
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat INTS2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTS2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    INT2_HUMAN, Q9H0H0: Nucleus membrane; Single-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane2
    cytosol1
    endoplasmic reticulum1
    extracellular1
    golgi apparatus1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--
    GO:0016021integral component of membrane IEA--
    GO:0031965nuclear membrane IEA--
    GO:0032039integrator complex IDA16239144

    Find genes that share ontologies with INTS2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for INTS2
    Interactions:

        Search GeneGlobe Interaction Network for INTS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for INTS2 (Q9H0H03 ENSP000004142374) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    INTS5Q6P9B93, ENSP000003278894I2D: score=1 STRING: ENSP00000327889
    INTS1Q8N2013, ENSP000003857224I2D: score=1 STRING: ENSP00000385722
    INTS3Q68E013, ENSP000003186414I2D: score=1 STRING: ENSP00000318641
    INTS6Q9UL033, ENSP000003102604I2D: score=1 STRING: ENSP00000310260
    CPSF3LENSP000004134934STRING: ENSP00000413493
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016180snRNA processing IDA16239144

    Find genes that share ontologies with INTS2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for INTS2 (INT2)

    Selected Novoseek inferred chemical compound relationships for INTS2 gene (see all 83)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2-(hydroxymethyl)pyridine 88.3 1 16411688 (1)
    2,2'-bipyridine 77.8 3 16363818 (1), 20199051 (1), 16241145 (1)
    3,3-dimethyl-1-butanol 72.2 1 16411688 (1)
    4,4'-bipyridine 70.8 2 15252617 (1)
    trans-1,2-bis(4-pyridyl)ethylene 70.8 2 15252617 (1)
    copper(i) 69.7 3 16878922 (1), 18253464 (1), 14632530 (1)
    acetonitrile 68.9 15 18187198 (2), 18275066 (1), 19006294 (1), 15236555 (1) (see all 13)
    pyridine 68.2 8 19452073 (1), 16602768 (1), 17317290 (1), 2396015 (1) (see all 6)
    1,10-phenanthroline 67.2 4 19132936 (1), 19086049 (1), 16406550 (1), 18629409 (1)
    oxo 67.1 3 17566134 (1), 15554634 (1), 10499102 (1)



    Find genes that share compounds with INTS2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for INTS2 gene: 
    NM_020748.2  

    Unigene Cluster for INTS2:

    Integrator complex subunit 2
    Hs.279646  [show with all ESTs]
    Unigene Representative Sequence: NR_026641
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000444766(uc002izm.3 uc002izn.3) ENST00000251334 ENST00000583822
    ENST00000584967 ENST00000578805 ENST00000583076
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat INTS2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate INTS2 (see all 71):
    hsa-miR-548j hsa-miR-640 hsa-miR-3607-3p hsa-miR-4272 hsa-miR-30d hsa-miR-10b* hsa-miR-30a hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidINTS2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat INTS2
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: INTS2 (NM_020748)
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      QuantiTect SYBR Green Assays in human, mouse, rat INTS2
      QuantiFast Probe-based Assays in human, mouse, rat INTS2

    Additional mRNA sequence: 

    AK308307.1 AL136800.1 CR533582.1 NR_026641.1 

    8 DOTS entries:

    DT.108729  DT.91946501  DT.75125078  DT.120905689  DT.120905693  DT.100647275  DT.40196972  DT.97772673 

    Selected AceView cDNA sequences (see all 38):

    AB033113 AL136800 BX395093 BP361236 AW089398 NM_020748 AI873609 AA745269 
    CR533582 BX098692 BQ286160 AA665115 CD654771 BG060032 AL708082 BG258230 
    BI755440 W00376 BU190134 BU607369 CB850983 CD655209 BP353820 BP356796 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for INTS2 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a ·
    SP1:                                                                                                                          -                             -   
    SP2:                          -     -                                                                                                                           
    SP3:                    -     -     -                                                                                                                           
    SP4:                                                                                                                                                            
    SP5:                                -                                                                                                                           

    ExUns: 17b ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25
    SP1:                                                            
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for INTS2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    INTS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTTTAAGT
    INTS2 Expression
    About this image

    INTS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    INTS2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.279646
        Custom PCR Arrays for INTS2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for INTS2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ints21 , 5 integrator complex subunit 21, 5 88.92(n)1
    96.23(a)1
      11 (51.71 cM)5
    704221  NM_027421.21  NP_081697.21 
     862106815 
    chicken
    (Gallus gallus)
    Aves INTS21 integrator complex subunit 2 79.83(n)
    91.34(a)
      417640  NM_001030722.1  NP_001025893.1 
    lizard
    (Anolis carolinensis)
    Reptilia INTS26
    integrator complex subunit 2
    92(a)
    1 ↔ 1
    GL343470.1(931-12107)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ032170.12   -- 78.43(n)    BJ032170.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BI867948.12   -- 70.3(n)    BI867948.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta IntS21 Integrator 2 49.27(n)
    42.39(a)
      32745  NM_133004.2  NP_573232.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ZC376.66
    Protein ZC376.6, isoform b (ZC376.6) mRNA, complet...
    18(a)
    1 ↔ 1
    V(14185785-14192158) WBGene00013877


    ENSEMBL Gene Tree for INTS2 (if available)
    TreeFam Gene Tree for INTS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for INTS2 (see all 1263)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs557518691,2
    C--55344748(+) TTTTT-/T/TT  
     TTTTTTT
    CTGAG
    2 -- int11NA 2
    rs743830271,2
    C--59943068(+) AGTTT-/AAAAAA 2 -- nc-transcript-variantut310--------
    rs72134691,2
    C,F,A,H--59943288(+) TCATTC/TTCATA 2 -- nc-transcript-variantut3112Minor allele frequency- T:0.09NS EA NA WA 1310
    rs72150761,2
    C,F,A,H--59943532(+) ACCAGT/CCTGGG 2 -- nc-transcript-variantut31 ese37Minor allele frequency- C:0.34NA WA CSA 130
    rs116499391,2
    C,H--59943559(+) CGTCTC/TTACTA 2 -- nc-transcript-variantut31 ese310Minor allele frequency- T:0.01NA WA CSA EA 136
    rs1829271661,2
    --59943589(+) GGCGCA/GTGCCT 2 -- nc-transcript-variantut310--------
    rs96307351,2
    C,A--59943704(+) CAGGGG/CAAGAC 2 -- nc-transcript-variantut31 ese35Minor allele frequency- C:0.22NA WA EA 362
    rs1116294581,2
    C--59943707(+) GGGAAA/GACTCC 2 -- nc-transcript-variantut310--------
    rs1150768261,2
    F--59943914(+) CCTTCG/AGCAAG 2 -- nc-transcript-variantut311Minor allele frequency- A:0.01WA 118
    rs1872642621,2
    --59944341(+) GCTACC/TTGCCT 2 -- nc-transcript-variantut310--------

    HapMap Linkage Disequilibrium report for INTS2 (59942728 - 60005377 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for INTS2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2673812CNV Deletion23128226
    esv269932CNV Insertion20981092

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing INTS2
    DNA2.0 Custom Variant and Variant Library Synthesis for INTS2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611346    OMIM disorders: --


    Find genes that share disorders with INTS2           About GenesLikeMe

    8 Novoseek inferred disease relationships for INTS2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    complex partial seizures 12 3 10390770 (1), 11022139 (1), 10768157 (1)
    oncocytoma 6.27 2 7631937 (1), 1721653 (1)
    tuberous sclerosis 2.62 3 16648488 (1), 15466161 (1), 16816403 (1)
    cervical cancer 0 1 19258961 (1)
    reflux 0 1 18844344 (1)
    tumors 0 7 15927264 (1), 16816403 (1), 19258506 (1), 1721653 (1) (see all 7)
    cancer 0 5 17542650 (1), 19258506 (1), 19860841 (1), 20023900 (1) (see all 5)
    cysts 0 3 7631937 (1), 1721653 (1), 7945904 (1)


    Export disorders for INTS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for INTS2 gene, integrated from 10 sources (see all 328):
    (articles sorted by number of sources associating them with INTS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PubMed id 16239144)1, 2, 3 Baillat D....Shiekhattar R. (Cell 2005)
    2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    3. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2 Nagase T.... Ohara O. (DNA Res. 1999)
    4. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    5. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    6. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)
    10. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57508 HGNC: 29241 AceView: KIAA1287 Ensembl:ENSG00000108506 euGenes: HUgn57508
    ECgene: INTS2 H-InvDB: INTS2

    (According to HUGE)
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    HUGE: KIAA1287

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for INTS2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for INTS2 gene:
    Search GeneIP for patents involving INTS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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