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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

INTS2 Gene

protein-coding   GIFtS: 46
GCID: GC17M059942

integrator complex subunit 2

(Previous name: KIAA1287 )
(Previous symbol: KIAA1287)
 Explore 17 diseases affiliated with
INTS2 via our new
 Human Malady Compendium 
Biological research products
for INTS2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Integrator Complex Subunit 21 2
KIAA12871 2 3
INT21 2
Int23

External Ids:    HGNC: 292411   Entrez Gene: 575082   Ensembl: ENSG000001085067   OMIM: 6113465   UniProtKB: Q9H0H03   
ORGUL members:         
NONCODE:n407180    

Export aliases for INTS2 gene to outside databases

Previous GC identifers: GC17M057298 GC17M055308


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for INTS2:
INTS2 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large
subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2
(RNU2; MIM 180690) (Baillat et al., 2005 (PubMed 16239144)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: INT2_HUMAN, Q9H0H0
Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2
transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal
domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the INTS2 gene promoter:
         C/EBPbeta   STAT1   STAT4   STAT1beta   E47   STAT1alpha   POU2F1   POU2F1a   STAT2   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidINTS2 promoter sequence
   Search SABiosciences Chromatin IP Primers for INTS2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INTS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.2   Ensembl cytogenetic band:  17q23.2   HGNC cytogenetic band: 17q23.2

INTS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INTS2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M059942:  view genomic region     (about GC identifiers)

Start:
59,942,728 bp from pter      End:
60,005,377 bp from pter
Size:
62,650 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: INT2_HUMAN, Q9H0H0 (See protein sequence)
Recommended Name: Integrator complex subunit 2  
Size: 1204 amino acids; 134323 Da
Subunit: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6,
INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12
Subcellular location: Nucleus membrane; Single-pass membrane protein (Potential)
Caution: It is uncertain whether Met-1 or Met-9 is the initiator. Orthologous sequences (mouse and chicken) have
shorter N-terminus
Secondary accessions: Q9ULD3

Explore the universe of human proteins at neXtProt for INTS2: NX_Q9H0H0

Post-translational modifications:

  • Phosphorylated upon DNA damage, probably by ATM or ATR1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H0H0

  • INTS2 Protein expression data from MOPED and PaxDb:    About this image 
    INTS2 Protein Expression
    REFSEQ proteins: NP_065799.1  
    ENSEMBL proteins: 
     ENSP00000414237   ENSP00000251334   ENSP00000461996  

    Human Recombinant Protein Products for INTS2: 
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    OriGene Protein Over-expression Lysate: INTS2
    OriGene Custom Protein Services for INTS2 
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    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for INTS2

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--
    GO:0016021integral to membrane IEA--
    GO:0031965nuclear membrane IEA--
    GO:0032039integrator complex IDA16239144

    INTS2 for ontologies           About GeneDecksing



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    Search ThermoFisher Antibodies for INTS2

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    Uscn ELISAs and CLIAs for INTS2


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    INTS2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR026236 Int2

    Graphical View of Domain Structure for InterPro Entry Q9H0H0

    ProtoNet protein and cluster: Q9H0H0

    UniProtKB/Swiss-Prot: INT2_HUMAN, Q9H0H0
    Similarity: Belongs to the Integrator subunit 2 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: INT2_HUMAN, Q9H0H0
    Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2
    transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal
    domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16239144
         
    INTS2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for INTS2:
     Increased circadian period len  Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Ints2):
     mortality/aging 

    INTS2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for INTS2 

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: INTS2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat INTS2
    8/71 QIAGEN miScript miRNA Assays for microRNAs that regulate INTS2 (see all 71):
    hsa-miR-548j hsa-miR-640 hsa-miR-3607-3p hsa-miR-4272 hsa-miR-30d hsa-miR-10b* hsa-miR-30a hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidINTS2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for INTS2 (see all 7)
    OriGene shRNA RFP: INTS2
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    Sirion Biotech Custom design and validation of potent shRNA sequences against INTS2 

    Gene Editing
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    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    Sirion Biotech Customized inducible overexpressing cell line services for INTS2

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTS2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for INTS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/14 Interacting proteins for INTS2 (Q9H0H03 ENSP000004142374) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    INTS5Q6P9B93, ENSP000003278894I2D: score=1 STRING: ENSP00000327889
    INTS1Q8N2013, ENSP000003857224I2D: score=1 STRING: ENSP00000385722
    INTS3Q68E013, ENSP000003186414I2D: score=1 STRING: ENSP00000318641
    INTS6Q9UL033, ENSP000003102604I2D: score=1 STRING: ENSP00000310260
    CPSF3LENSP000004134934STRING: ENSP00000413493
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016180snRNA processing IDA16239144

    INTS2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    INTS2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for INTS2
    10/83 Novoseek chemical compound relationships for INTS2 gene (see all 83)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2-(hydroxymethyl)pyridine 88.3 1 16411688 (1)
    2,2'-bipyridine 77.8 3 16363818 (1), 20199051 (1), 16241145 (1)
    3,3-dimethyl-1-butanol 72.2 1 16411688 (1)
    4,4'-bipyridine 70.8 2 15252617 (1)
    trans-1,2-bis(4-pyridyl)ethylene 70.8 2 15252617 (1)
    copper(i) 69.7 3 16878922 (1), 18253464 (1), 14632530 (1)
    acetonitrile 68.9 15 18187198 (2), 18275066 (1), 19006294 (1), 15236555 (1) (see all 13)
    pyridine 68.2 8 19452073 (1), 16602768 (1), 17317290 (1), 2396015 (1) (see all 6)
    1,10-phenanthroline 67.2 4 19132936 (1), 19086049 (1), 16406550 (1), 18629409 (1)
    oxo 67.1 3 17566134 (1), 15554634 (1), 10499102 (1)

    Search CenterWatch for drugs/clinical trials and news about INTS2 / INT2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for INTS2 gene: 
    NM_020748.2  

    Unigene Cluster for INTS2:

    Integrator complex subunit 2
    Hs.279646  [show with all ESTs]
    Unigene Representative Sequence: NR_026641
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000444766(uc002izm.3 uc002izn.3) ENST00000251334 ENST00000583822
    ENST00000584967 ENST00000578805 ENST00000583076

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat INTS2
    8/71 QIAGEN miScript miRNA Assays for microRNAs that regulate INTS2 (see all 71):
    hsa-miR-548j hsa-miR-640 hsa-miR-3607-3p hsa-miR-4272 hsa-miR-30d hsa-miR-10b* hsa-miR-30a hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidINTS2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for INTS2 (see all 7)
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    OriGene siRNA: INTS2
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    Clone
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    GenScript: all cDNA clones in your preferred vector: INTS2 (NM_020748)
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat INTS2 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INTS2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INTS2

    Additional cDNA sequence: 

    AK308307.1 AL136800.1 CR533582.1 NR_026641.1 

    8 DOTS entries:

    DT.108729  DT.91946501  DT.75125078  DT.120905689  DT.120905693  DT.100647275  DT.40196972  DT.97772673 

    24/38 AceView cDNA sequences (see all 38):

    AW089398 AA745269 AB033113 NM_020748 AI873609 CR533582 AA665115 BX098692 
    AL136800 BP361236 BQ286160 BX395093 BI755440 BX349974 CD654771 AL708082 
    CB850983 BM469099 AI926383 BU190134 BG060032 BU607369 W00376 BP356796 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for INTS2 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a ·
    SP1:                                                                                                                          -                             -   
    SP2:                          -     -                                                                                                                           
    SP3:                    -     -     -                                                                                                                           
    SP4:                                                                                                                                                            
    SP5:                                -                                                                                                                           

    ExUns: 17b ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25
    SP1:                                                            
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for INTS2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    INTS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATTTTAAGT
    INTS2 Expression
    About this image
    See INTS2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for INTS2

    SOURCE GeneReport for Unigene cluster: Hs.279646
        SABiosciences Custom PCR Arrays for INTS2

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INTS2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for INTS2 gene from 7/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ints21 , 5 integrator complex subunit 21, 5 88.92(n)1
    96.23(a)1
      11 (51.71 cM)5
    704221  NM_027421.21  NP_081697.21 
     862106815 
    chicken
    (Gallus gallus)
    Aves INTS21 integrator complex subunit 2 79.83(n)
    91.34(a)
      417640  NM_001030722.1  NP_001025893.1 
    lizard
    (Anolis carolinensis)
    Reptilia INTS26
    --
    93(a)
    1 ↔ 1
    GL343470.1(2116-11474)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ032170.12   -- 78.43(n)    BJ032170.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BI867948.12   -- 70.3(n)    BI867948.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta IntS21 Integrator 2 48.82(n)
    41.92(a)
      32745  NM_133004.1  NP_573232.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ZC376.66
    Protein ZC376.6, isoform a
    16(a)
    1 ↔ 1
    V(14185770-14192143)


    ENSEMBL Gene Tree for INTS2 (if available)
    TreeFam Gene Tree for INTS2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/961 NCBI SNPs in INTS2 are shown (see all 961    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1872200671,2
    --59942301(+) CATCCA/TGGCTA 3 -- ds5001 us2k10--------
    rs1138603061,2
    C--59942321(+) AACCCC/TGTCTC 3 -- us2k1 ds50011Minor allele frequency- T:0.50WA 2
    rs1906876461,2
    --59942742(+) TAAAGA/GATATG 3 -- us2k1 ut31 nc-transcript-variant0--------
    rs743830271,2
    C--59943068(+) AGTTT-/AAAAAA 2 -- ut31 nc-transcript-variant0--------
    rs72134691,2
    C,F,A,H--59943288(+) TCATTC/TTCATA 2 -- ut31 nc-transcript-variant12Minor allele frequency- T:0.09NS EA NA WA 1310
    rs72150761,2
    C,F,A,H--59943532(+) ACCAGT/CCTGGG 2 -- nc-transcript-variantut31 ese37Minor allele frequency- C:0.34NA WA CSA 130
    rs116499391,2
    C,H--59943559(+) CGTCTC/TTACTA 2 -- nc-transcript-variantut31 ese310Minor allele frequency- T:0.01NA WA CSA EA 136
    rs1829271661,2
    --59943589(+) GGCGCA/GTGCCT 2 -- ut31 nc-transcript-variant0--------
    rs96307351,2
    C,A--59943704(+) CAGGGG/CAAGAC 2 -- nc-transcript-variantut31 ese35Minor allele frequency- C:0.22NA WA EA 362
    rs1116294581,2
    C--59943707(+) GGGAAA/GACTCC 2 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for INTS2 (59942728 - 60005377 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for INTS2: --

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    INTS2 for disorders           About GeneDecksing

    OMIM gene information: 611346    OMIM disorders: --

    17 diseases for INTS2:    About MalaCards
    temporal lobe epilepsy    abdominal aortic aneurysm    aortic aneurysm    tuberous sclerosis
    acute promyelocytic leukemia    appendicitis    gallbladder carcinoma    seizures
    acute leukemia    meningitis    leukemia    breast cancer
    cerebritis    cholesterol    hypoxia    carcinoma
    alcoholism

    8 Novoseek disease relationships for INTS2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    complex partial seizures 12 3 10390770 (1), 11022139 (1), 10768157 (1)
    oncocytoma 6.27 2 7631937 (1), 1721653 (1)
    tuberous sclerosis 2.62 3 16648488 (1), 15466161 (1), 16816403 (1)
    cervical cancer 0 1 19258961 (1)
    reflux 0 1 18844344 (1)
    tumors 0 7 15927264 (1), 16816403 (1), 19258506 (1), 1721653 (1) (see all 7)
    cancer 0 5 17542650 (1), 19258506 (1), 19860841 (1), 20023900 (1) (see all 5)
    cysts 0 3 7631937 (1), 1721653 (1), 7945904 (1)


    Export disorders for INTS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for INTS2 gene, integrated from 9 sources (see all 324):
    (articles sorted by number of sources associating them with INTS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PubMed id 16239144)1, 2, 3 Baillat D....Shiekhattar R. (2005)
    2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    3. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2 Nagase T.... Ohara O. (1999)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    5. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    6. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    7. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. Streamlined analysis schema for high-throughput ident ification of endogenous protein complexes. (PubMed id 20133760)1 Malovannaya A....Qin J. (2010)
    10. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57508 HGNC: 29241 AceView: KIAA1287 Ensembl:ENSG00000108506 euGenes: HUgn57508
    ECgene: INTS2 H-InvDB: INTS2

    (According to HUGE)
    About This Section
    HUGE: KIAA1287

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for INTS2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for INTS2 gene:
    Search GeneIP for patents involving INTS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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