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Aliases for INTS14 Gene

Aliases for INTS14 Gene

  • Integrator Complex Subunit 14 2 3
  • Von Willebrand Factor A Domain Containing 9 2 3 5
  • VWA9 3 4 5
  • C15orf44 3 4
  • Von Willebrand Factor A Domain-Containing Protein 9 3
  • Chromosome 15 Open Reading Frame 44 2
  • UPF0464 Protein C15orf44 3

External Ids for INTS14 Gene

Previous HGNC Symbols for INTS14 Gene

  • C15orf44
  • VWA9

Summaries for INTS14 Gene

GeneCards Summary for INTS14 Gene

INTS14 (Integrator Complex Subunit 14) is a Protein Coding gene. Among its related pathways are Gene Expression and Formation of HIV elongation complex in the absence of HIV Tat.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INTS14 Gene

Genomics for INTS14 Gene

Regulatory Elements for INTS14 Gene

Enhancers for INTS14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F065576 1.2 ENCODE 15.5 +34.3 34260 1.9 HDGF PKNOX1 MLX ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC24A1 ENSG00000259635 MTFMT HNRNPA1P44 RNU5A-1 ENSG00000259346 RNU5B-1 ENSG00000239465 INTS14 SNORD16
GH15F065830 1.4 Ensembl ENCODE 10.6 -223.3 -223312 7.6 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC24A1 ENSG00000260773 DENND4A LOC646358 RAB11A INTS14 HACD3 IGDCC4 DPP8 ENSG00000283249
GH15F065578 0.9 ENCODE 15.7 +31.2 31247 2.3 PKNOX1 FEZF1 ZBTB40 ZNF2 ZEB1 YY1 FOS ZNF263 ZNF362 ZNF280D SLC24A1 INTS14 RNU6-19P IGDCC4 GC15P066907 GC15P067908
GH15F065638 1.1 Ensembl ENCODE 10.7 -27.5 -27512 0.8 HDGF ELF3 CBX3 PKNOX1 ARNT WRNIP1 NFXL1 ZNF2 RAD21 ZNF366 SLC24A1 MTFMT INTS14 ENSG00000238311 DIS3L GC15P067953 ENSG00000275638
GH15F065560 0.7 ENCODE 15.9 +49.3 49346 2.2 MAZ ZNF687 ZNF362 PKNOX1 SIN3A MNT DPF2 E2F1 GATA3 KLF9 SLC24A1 INTS14 GC15P067908 GC15P067942
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around INTS14 on UCSC Golden Path with GeneCards custom track

Promoters for INTS14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000409806 389 1801 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548

Genomic Location for INTS14 Gene

65,578,753 bp from pter
65,611,289 bp from pter
32,537 bases
Minus strand

Genomic View for INTS14 Gene

Genes around INTS14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INTS14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INTS14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INTS14 Gene

Proteins for INTS14 Gene

  • Protein details for INTS14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    von Willebrand factor A domain-containing protein 9
    Protein Accession:
    Secondary Accessions:
    • B4DDI6
    • B4DVD5
    • Q49AH8
    • Q96HX5
    • Q9H0S5

    Protein attributes for INTS14 Gene

    518 amino acids
    Molecular mass:
    57471 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for INTS14 Gene


neXtProt entry for INTS14 Gene

Post-translational modifications for INTS14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for INTS14 Gene

Domains & Families for INTS14 Gene

Gene Families for INTS14 Gene

Protein Domains for INTS14 Gene

Suggested Antigen Peptide Sequences for INTS14 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 VWFA domain.
  • Belongs to the VWA9 family.
  • Contains 1 VWFA domain.
  • Belongs to the VWA9 family.
genes like me logo Genes that share domains with INTS14: view

Function for INTS14 Gene

genes like me logo Genes that share phenotypes with INTS14: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for INTS14 Gene

Localization for INTS14 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for INTS14 gene
Compartment Confidence
nucleus 5
plasma membrane 2
mitochondrion 2
cytosol 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for INTS14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with INTS14: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for INTS14 Gene

Pathways & Interactions for INTS14 Gene

genes like me logo Genes that share pathways with INTS14: view

Pathways by source for INTS14 Gene

2 Reactome pathways for INTS14 Gene

Gene Ontology (GO) - Biological Process for INTS14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042795 snRNA transcription from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with INTS14: view

No data available for SIGNOR curated interactions for INTS14 Gene

Transcripts for INTS14 Gene

Unigene Clusters for INTS14 Gene

Von Willebrand factor A domain containing 9:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for INTS14 Gene

No ASD Table

Relevant External Links for INTS14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for INTS14 Gene

NURSA nuclear receptor signaling pathways regulating expression of INTS14 Gene:


SOURCE GeneReport for Unigene cluster for INTS14 Gene:


mRNA Expression by UniProt/SwissProt for INTS14 Gene:

Tissue specificity: Strongly expressed in numerous cancer cells compared with their non-cancerous counterparts (lung, prostate, colon, stomach and skin).

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for INTS14 Gene

Orthologs for INTS14 Gene

This gene was present in the common ancestor of animals.

Orthologs for INTS14 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia VWA9 34 35
  • 99.79 (n)
(Canis familiaris)
Mammalia VWA9 34 35
  • 93.95 (n)
(Bos Taurus)
Mammalia VWA9 34 35
  • 92.52 (n)
(Mus musculus)
Mammalia Vwa9 34 16 35
  • 90.97 (n)
(Rattus norvegicus)
Mammalia Vwa9 34
  • 90.75 (n)
(Monodelphis domestica)
Mammalia VWA9 35
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia VWA9 35
  • 77 (a)
(Gallus gallus)
Aves VWA9 35
  • 82 (a)
C10H15ORF44 34
  • 81.41 (n)
(Anolis carolinensis)
Reptilia VWA9 35
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia vwa9 34
  • 77.78 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.3805 34
(Danio rerio)
Actinopterygii vwa9 34 35
  • 71.63 (n)
wufi19c12 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007540 34
  • 49.79 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4785 34 35
  • 47.17 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7256 35
  • 36 (a)
Species where no ortholog for INTS14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for INTS14 Gene

Gene Tree for INTS14 (if available)
Gene Tree for INTS14 (if available)

Paralogs for INTS14 Gene

No data available for Paralogs for INTS14 Gene

Variants for INTS14 Gene

Sequence variations from dbSNP and Humsavar for INTS14 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1061301 -- 65,578,267(+) GTATT(C/T)TTAGT intron-variant, downstream-variant-500B, utr-variant-3-prime
rs10914 -- 65,579,082(+) GAGCC(C/T)CTGCC nc-transcript-variant, utr-variant-3-prime
rs111308290 -- 65,607,817(+) TATTT(A/G)ACAAA intron-variant
rs111464857 -- 65,599,980(+) TTTAA(A/C/T)GCAGT intron-variant
rs111475676 -- 65,612,182(+) TCTAA(C/T)CATGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for INTS14 Gene

Variant ID Type Subtype PubMed ID
nsv94754 CNV deletion 16902084
nsv833042 CNV loss 17160897
nsv1150102 CNV deletion 26484159
esv3552577 CNV deletion 23714750
esv2669017 CNV deletion 23128226

Variation tolerance for INTS14 Gene

Residual Variation Intolerance Score: 27.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.91; 18.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for INTS14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INTS14 Gene

Disorders for INTS14 Gene

Relevant External Links for INTS14

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for INTS14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for INTS14 Gene

Publications for INTS14 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  5. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PMID: 23667531) Cox J.L. … Rizzino A. (PLoS ONE 2013) 3 64

Products for INTS14 Gene

Sources for INTS14 Gene

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