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Aliases for INTS14 Gene

Aliases for INTS14 Gene

  • Integrator Complex Subunit 14 2 3 5
  • Von Willebrand Factor A Domain-Containing Protein 9 3 4
  • Von Willebrand Factor A Domain Containing 9 2 3
  • C15orf44 3 4
  • Chromosome 15 Open Reading Frame 44 2
  • UPF0464 Protein C15orf44 3
  • VWA9 3

External Ids for INTS14 Gene

Previous HGNC Symbols for INTS14 Gene

  • C15orf44
  • VWA9

Summaries for INTS14 Gene

GeneCards Summary for INTS14 Gene

INTS14 (Integrator Complex Subunit 14) is a Protein Coding gene. Among its related pathways are RNA polymerase II transcribes snRNA genes and Gene Expression.

UniProtKB/Swiss-Prot for INTS14 Gene

  • Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing.

Additional gene information for INTS14 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INTS14 Gene

Genomics for INTS14 Gene

Regulatory Elements for INTS14 Gene

Enhancers for INTS14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15H065609 1.2 ENCODE 128.3 -0.1 -124 3 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 SP3 INTS14 PARP16 ENSG00000260773 SNORD16 PDCD7 RPL35AP32 ENSG00000264937 ENSG00000259635 SLC24A1 TIPIN
GH15H065295 1.7 FANTOM5 ENCODE dbSUPER 77.1 +313.9 313923 4 HNRNPUL1 PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 PARP16 INTS14 ZNF609 TRIP4 ENSG00000264937 PDCD7 ENSG00000259635 MTFMT ENSG00000265967 CSNK1G1
GH15H065303 1.8 FANTOM5 ENCODE dbSUPER 63 +306.8 306818 2 MLX FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC ZFP41 MEF2D SSRP1 PARP16 ZNF609 PDCD7 INTS14 TRIP4 SLC24A1 CILP CSNK1G1 ENSG00000264937 ENSG00000259635
GH15H066459 1.1 Ensembl ENCODE 66.1 -850.1 -850072 4 ZFP64 KLF17 ZNF138 FOS EGR2 ZNF202 ZNF654 ZNF680 ZC3H11A CEBPB INTS14 TIPIN ENSG00000260773 SNORD16 SNAPC5 SLC24A1 ZWILCH RPL35AP32 DIS3L LOC646358
GH15H066502 1.4 ENCODE dbSUPER 46.2 -892.9 -892929 4 PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B INTS14 TIPIN ENSG00000260773 SNAPC5 SNORD16 DIS3L RPL35AP32 ZWILCH RPL4 HACD3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around INTS14 on UCSC Golden Path with GeneCards custom track

Promoters for INTS14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000078101 189 1401 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 SP3

Genomic Location for INTS14 Gene

Chromosome:
15
Start:
65,578,753 bp from pter
End:
65,611,289 bp from pter
Size:
32,537 bases
Orientation:
Minus strand

Genomic View for INTS14 Gene

Genes around INTS14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INTS14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INTS14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INTS14 Gene

Proteins for INTS14 Gene

  • Protein details for INTS14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96SY0-INT14_HUMAN
    Recommended name:
    Integrator complex subunit 14
    Protein Accession:
    Q96SY0
    Secondary Accessions:
    • B4DDI6
    • B4DVD5
    • Q49AH8
    • Q96HX5
    • Q9H0S5

    Protein attributes for INTS14 Gene

    Size:
    518 amino acids
    Molecular mass:
    57471 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for INTS14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for INTS14 Gene

Post-translational modifications for INTS14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for INTS14 Gene

Domains & Families for INTS14 Gene

Gene Families for INTS14 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for INTS14 Gene

Suggested Antigen Peptide Sequences for INTS14 Gene

Graphical View of Domain Structure for InterPro Entry

Q96SY0

UniProtKB/Swiss-Prot:

INT14_HUMAN :
  • Belongs to the INTS14 family.
Family:
  • Belongs to the INTS14 family.
genes like me logo Genes that share domains with INTS14: view

Function for INTS14 Gene

Molecular function for INTS14 Gene

UniProtKB/Swiss-Prot Function:
Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing.

Phenotypes From GWAS Catalog for INTS14 Gene

genes like me logo Genes that share phenotypes with INTS14: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for INTS14
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for INTS14 Gene

Localization for INTS14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for INTS14 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for INTS14 gene
Compartment Confidence
nucleus 5
plasma membrane 2
mitochondrion 2
cytosol 2
extracellular 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nuclear bodies (2)
  • Nuclear membrane (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for INTS14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with INTS14: view

Pathways & Interactions for INTS14 Gene

genes like me logo Genes that share pathways with INTS14: view

Pathways by source for INTS14 Gene

2 Reactome pathways for INTS14 Gene

Gene Ontology (GO) - Biological Process for INTS14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042795 snRNA transcription from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with INTS14: view

No data available for SIGNOR curated interactions for INTS14 Gene

Drugs & Compounds for INTS14 Gene

No Compound Related Data Available

Transcripts for INTS14 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for INTS14
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for INTS14 Gene

No ASD Table

Relevant External Links for INTS14 Gene

GeneLoc Exon Structure for
INTS14
ECgene alternative splicing isoforms for
INTS14

Expression for INTS14 Gene

NURSA nuclear receptor signaling pathways regulating expression of INTS14 Gene:

INTS14

mRNA Expression by UniProt/SwissProt for INTS14 Gene:

Q96SY0-INT14_HUMAN
Tissue specificity: Strongly expressed in numerous cancer cells compared with their non-cancerous counterparts (lung, prostate, colon, stomach and skin).

Evidence on tissue expression from TISSUES for INTS14 Gene

  • Nervous system(4.8)
  • Adrenal gland(4.2)
  • Lung(2.1)

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for INTS14 Gene

Orthologs for INTS14 Gene

This gene was present in the common ancestor of animals.

Orthologs for INTS14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VWA9 33 34
  • 99.79 (n)
dog
(Canis familiaris)
Mammalia VWA9 33 34
  • 93.95 (n)
cow
(Bos Taurus)
Mammalia VWA9 33 34
  • 92.52 (n)
mouse
(Mus musculus)
Mammalia Vwa9 33 34
  • 90.97 (n)
Ints14 16
rat
(Rattus norvegicus)
Mammalia Vwa9 33
  • 90.75 (n)
oppossum
(Monodelphis domestica)
Mammalia VWA9 34
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia VWA9 34
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves VWA9 34
  • 82 (a)
OneToOne
C10H15ORF44 33
  • 81.41 (n)
lizard
(Anolis carolinensis)
Reptilia VWA9 34
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vwa9 33
  • 77.78 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.3805 33
zebrafish
(Danio rerio)
Actinopterygii vwa9 33 34
  • 71.63 (n)
wufi19c12 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007540 33
  • 49.79 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4785 33 34
  • 47.17 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7256 34
  • 36 (a)
OneToOne
Species where no ortholog for INTS14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for INTS14 Gene

ENSEMBL:
Gene Tree for INTS14 (if available)
TreeFam:
Gene Tree for INTS14 (if available)

Paralogs for INTS14 Gene

No data available for Paralogs for INTS14 Gene

Variants for INTS14 Gene

Sequence variations from dbSNP and Humsavar for INTS14 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000033434 -- 65,584,256(+) GCTAT(-/G)GGCTT intron-variant
rs1000090751 -- 65,588,539(+) GGCTT(C/G)TGCCT intron-variant
rs1000169288 -- 65,603,520(+) GGTCC(A/C)GGCTG intron-variant
rs1000256554 -- 65,590,978(+) ATATC(C/T)AGGTG intron-variant
rs1000270552 -- 65,596,430(+) AAAGA(A/G)GAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for INTS14 Gene

Variant ID Type Subtype PubMed ID
esv2669017 CNV deletion 23128226
esv3552577 CNV deletion 23714750
nsv1150102 CNV deletion 26484159
nsv833042 CNV loss 17160897
nsv94754 CNV deletion 16902084

Variation tolerance for INTS14 Gene

Residual Variation Intolerance Score: 27.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.91; 18.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for INTS14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
INTS14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INTS14 Gene

Disorders for INTS14 Gene

Relevant External Links for INTS14

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
INTS14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
INTS14

No disorders were found for INTS14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for INTS14 Gene

Publications for INTS14 Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 60
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 60

Products for INTS14 Gene

Sources for INTS14 Gene

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