INTS12 Gene
protein-coding GIFtS: 48
GCID: GC04M106603
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integrator complex subunit 12(Previous name: PHD finger protein 22 )
(Previous symbol: PHF22)
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Aliases
for INTS12 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Integrator Complex Subunit 121 2 | | SBBI221 | | PHF221 2 3 | | Hypothetical Nuclear Factor SBBI222 | | PHD Finger Protein 221 2 3 | | Int123 | | INT121 2 | | |
Export aliases for INTS12 gene to outside databasesPrevious GC identifers: GC04M106823 GC04M102338 |
Summaries
for INTS12 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for INTS12:
INTS12 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II largesubunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2(RNU2; MIM 180690) (Baillat et al., 2005 (PubMed 16239144)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: INT12_HUMAN, Q96CB8Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminaldomain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes
Gene Wiki entry for INTS12
|
Genomic Views
for INTS12 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the INTS12 gene promoter:
HSF1 (long) XBP-1 Cdc5 LCR-F1 S8 POU2F1 POU2F1a FOXO4 HSF1short Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for INTS12
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INTS12 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q24 Ensembl cytogenetic band: 4q24 HGNC cytogenetic band: 4q24INTS12 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M106603: view genomic region
(about GC identifiers)
Start:
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106,603,784 bp from pter |
End:
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106,817,143 bp from pter |
Size:
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213,360 bases |
Orientation:
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minus strand |
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Proteins
for INTS12 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: INT12_HUMAN, Q96CB8 (See
protein sequence)Recommended Name: Integrator complex subunit 12 Size: 462 amino acids; 48808 Da
Subunit: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6,INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAF99604.1; Type=Frameshift; Positions=439;
Secondary accessions: B2RC48 Q3B6Z3 Q9HD71Explore the universe of human proteins at neXtProt for INTS12: NX_Q96CB8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96CB8
INTS12 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001135943.1 NP_065128.2
ENSEMBL proteins: ENSP00000378221 ENSP00000340737 ENSP00000415433 ENSP00000423618 ENSP00000412317 ENSP00000396309 ENSP00000396729 ENSP00000422856 ENSP00000422048
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
INTS12 for ontologies About GeneDecksing
INTS12 Antibody Products:
Assay Products for INTS12: |
Protein
Domains /
Families
for INTS12 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
INTS12 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96CB8ProtoNet protein and cluster: Q96CB8 1 Blocks protein family: IPB001965 Zn-finger-like
UniProtKB/Swiss-Prot: INT12_HUMAN, Q96CB8Similarity: Contains 1 PHD-type zinc finger |
Function
for INTS12 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: INT12_HUMAN, Q96CB8Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminaldomain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for INTS12 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for INTS12 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for INTS12 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INTS12 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTS12 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
INTS12 for ontologies About GeneDecksing
Animal Models:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Ints12):
INTS12 for phenotypes About GeneDecksing
|
Pathways & Interactions
for INTS12 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for INTS12
5/589 Interacting proteins for INTS12 (Q96CB82, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 589)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
INTS12 for ontologies About GeneDecksing
|
Drugs & Compounds
for INTS12 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for INTS12
Search CenterWatch for drugs/clinical trials and news about INTS12 / INT12
|
Transcripts
for INTS12 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for INTS12 gene (2 alternative transcripts): NM_001142471.1 NM_020395.3 Unigene Cluster for INTS12: Integrator complex subunit 12 Hs.480454 [show with all ESTs]Unigene Representative Sequence: NM_02039510 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000394735 ENST00000340139(uc003hxw.3) ENST00000451321(uc010ilr.3)
ENST00000493425 ENST00000503746 ENST00000420368 ENST00000416543 ENST00000433009
ENST00000510876 ENST00000515819
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for INTS12 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for INTS12 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): INTS12 (NM_001142471) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for INTS12 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INTS12 |
Additional cDNA sequence: AF242524.1 AK314939.1 BC014442.1 9 DOTS entries: DT.100809930 DT.317035 DT.95268072 DT.75117298 DT.121240650 DT.92429662 DT.100809928 DT.86836954 DT.92429661 24/169 AceView cDNA sequences (see all 169): AA128558 CD743230 AI278012 Z44438 AA421978 AI373175 BI255383 AI311669 CD368462 BX106664 AL519775 CR596020 CA448208 BM716899 F05502 AA128559 CD366144 AA634213 AI335324 AA903217 CB156058 AA327849 AA459210 BM805289
GeneLoc Exon Structure
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Expression
for INTS12 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| INTS12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGATGGGAT
About this image
See INTS12 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for INTS12
SOURCE GeneReport for Unigene cluster: Hs.480454
SABiosciences Custom PCR Arrays for INTS12
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for INTS12
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat INTS12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INTS12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INTS12 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTS12 |
Orthologs
for INTS12 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for INTS12 gene from 6/18 species (see all 18) About this table
ENSEMBL Gene Tree for INTS12 (if available)
TreeFam Gene Tree for INTS12 (if available) |
Paralogs
for INTS12 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for INTS12 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing INTS12 |
|
Disorders
/ Diseases
for INTS12 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
INTS12 for disorders About GeneDecksing
OMIM gene information: 611355
OMIM disorders: --
6  diseases for INTS12: About MalaCardstrigonitis pulmonary function alcohol dependence urethritis
scoliosis alcoholism
1 Novoseek disease relationship for INTS12 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| adenocarcinoma |
9.61 |
3 |
9352443 (1), 9553811 (1) |
Human Genome Epidemiology (HuGE) Navigator: INTS12 (2 documents)
Export disorders for INTS12 gene to outside databases
|
Publications
for INTS12 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for INTS12 gene, integrated from 9 sources (see all 36):
(articles sorted by number of sources associating them with INTS12) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PubMed id 16239144)1, 2, 3 Baillat D....Shiekhattar R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (2011)
- Purification and identification of endogenous polySUMO conjugates. (PubMed id 21252943)1 Bruderer R....Hay R.T. (2011)
- Streamlined analysis schema for high-throughput ident ification of endogenous protein complexes. (PubMed id 20133760)1 Malovannaya A....Qin J. (2010)
- A systematic gene-based screen of chr4q22-q32 identif ies association of a novel susceptibility gene, DKK2, with the quantitative tra it of alcohol dependence symptom counts. (PubMed id 20332099)1 Kalsi G....Riley B.P. (2010)
- Meta-analyses of genome-wide association studies iden tify multiple loci associated with pulmonary function. (PubMed id 20010835)1 Hancock D.B....London S.J. (2010)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
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External Searches for INTS12 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing INTS12 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing INTS12 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing INTS12 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for INTS12 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for INTS12 gene:
Search GeneIP for patents involving INTS12
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for INTS12 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for INTS12 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for INTS12 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for INTS12 | | | OriGene Protein Over-expression Lysate for INTS12 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for INTS12 | | OriGene 3'-UTR Clone for INTS12 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for INTS12 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for INTS12 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for INTS12 | | OriGene Custom Protein Services for INTS12 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat INTS12 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing INTS12 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INTS12 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat INTS12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INTS12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INTS12 |
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| | | | Search Tocris compounds for INTS12 |
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 | | | INTS12 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTS12 |
|  |  |  | | | | ThermoFisher Antibodies for INTS12 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INTS12 |
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