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INTS12 Gene

protein-coding   GIFtS: 50
GCID: GC04M106603

Integrator Complex Subunit 12

(Previous name: PHD finger protein 22)
(Previous symbol: PHF22)
  Search for INTS12
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Integrator Complex Subunit 121 2
PHF221 2 3
PHD Finger Protein 221 2 3
Hypothetical Nuclear Factor SBBI221 2
INT122 5
Int123

External Ids:    HGNC: 250671   Entrez Gene: 571172   Ensembl: ENSG000001387857   OMIM: 6113555   UniProtKB: Q96CB83   

Export aliases for INTS12 gene to outside databases

Previous GC identifers: GC04M106823 GC04M102338


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for INTS12 Gene:
INTS12 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II
large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM
180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 (PubMed 16239144)).(supplied by OMIM, Mar 2008)

GeneCards Summary for INTS12 Gene:
INTS12 (integrator complex subunit 12) is a protein-coding gene.

UniProtKB/Swiss-Prot: INT12_HUMAN, Q96CB8
Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2
transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal
domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes

Gene Wiki entry for INTS12 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the INTS12 gene promoter:
         HSF1 (long)   XBP-1   Cdc5   LCR-F1   S8   POU2F1   POU2F1a   FOXO4   HSF1short   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidINTS12 promoter sequence
   Search Chromatin IP Primers for INTS12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat INTS12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q24   Ensembl cytogenetic band:  4q24   HGNC cytogenetic band: 4q24

INTS12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INTS12 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M106603:  view genomic region     (about GC identifiers)

Start:
106,603,784 bp from pter      End:
106,817,143 bp from pter
Size:
213,360 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: INT12_HUMAN, Q96CB8 (See protein sequence)
Recommended Name: Integrator complex subunit 12  
Size: 462 amino acids; 48808 Da
Subunit: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5,
INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12
Sequence caution: Sequence=AAF99604.1; Type=Frameshift; Positions=439;
Secondary accessions: B2RC48 Q3B6Z3 Q9HD71

Explore the universe of human proteins at neXtProt for INTS12: NX_Q96CB8

Explore proteomics data for INTS12 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See INTS12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001135943.1  NP_065128.2  

    ENSEMBL proteins: 
     ENSP00000378221   ENSP00000340737   ENSP00000415433   ENSP00000423618   ENSP00000412317  
     ENSP00000396309   ENSP00000396729   ENSP00000422856   ENSP00000422048  

    INTS12 Human Recombinant Protein Products:

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    Novus Biologicals INTS12 Lysates
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    Cloud-Clone Corp. Proteins for INTS12

     
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    Cloud-Clone Corp. ELISAs for INTS12
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    Search eBioscience for ELISAs for INTS12 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PHF: Zinc fingers, PHD-type

    5 InterPro protein domains:
     IPR001965 Znf_PHD
     IPR013083 Znf_RING/FYVE/PHD
     IPR019786 Zinc_finger_PHD-type_CS
     IPR011011 Znf_FYVE_PHD
     IPR019787 Znf_PHD-finger

    Graphical View of Domain Structure for InterPro Entry Q96CB8

    ProtoNet protein and cluster: Q96CB8

    1 Blocks protein domain: IPB001965 Zn-finger-like

    UniProtKB/Swiss-Prot: INT12_HUMAN, Q96CB8
    Similarity: Contains 1 PHD-type zinc finger


    Find genes that share domains with INTS12           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: INT12_HUMAN, Q96CB8
    Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2
    transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal
    domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16239144
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with INTS12           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Ints12):
     mortality/aging 

    Find genes that share phenotypes with INTS12           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for INTS12
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    miRNA
    Products:
        
    miRTarBase miRNAs that target INTS12:
    hsa-let-7a-5p (MIRT052640)

    Block miRNA regulation of human, mouse, rat INTS12 using miScript Target Protectors
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    GenScript: all cDNA clones in your preferred vector (see all 2): INTS12 (NM_001142471)
    Sino Biological Human cDNA Clone for INTS12
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INTS12

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTS12


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    INT12_HUMAN, Q96CB8: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032039integrator complex IDA16239144

    Find genes that share ontologies with INTS12           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for INTS12
    Interactions:

        Search GeneGlobe Interaction Network for INTS12

    Selected Interacting proteins for INTS12 (Q96CB82, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 618)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    INTS1Q8N2012, 3MINT-7945693 I2D: score=1 
    INTS3Q68E012, 3MINT-7945693 I2D: score=1 
    GATAD2BQ8WXI92MINT-7945693 MINT-8173832
    PRPF6O949062MINT-7945693 MINT-8173832
    AXIN1O151693I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016180snRNA processing IDA16239144

    Find genes that share ontologies with INTS12           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for INTS12 (INT12)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for INTS12 gene (2 alternative transcripts): 
    NM_001142471.1  NM_020395.3  

    Unigene Cluster for INTS12:

    Integrator complex subunit 12
    Hs.480454  [show with all ESTs]
    Unigene Representative Sequence: NM_020395
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394735 ENST00000340139(uc003hxw.3) ENST00000451321(uc010ilr.3)
    ENST00000493425 ENST00000503746 ENST00000420368 ENST00000416543 ENST00000433009
    ENST00000510876 ENST00000515819
    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat INTS12
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): INTS12 (NM_001142471)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INTS12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INTS12
    Primer
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    OriGene qPCR primer pairs and template standards for INTS12
    OriGene qSTAR qPCR primer pairs in human, mouse for INTS12
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat INTS12
      QuantiTect SYBR Green Assays in human, mouse, rat INTS12
      QuantiFast Probe-based Assays in human, mouse, rat INTS12

    Additional mRNA sequence: 

    AF242524.1 AK314939.1 BC014442.1 

    9 DOTS entries:

    DT.100809930  DT.317035  DT.95268072  DT.75117298  DT.121240650  DT.92429662  DT.100809928  DT.86836954 
    DT.92429661 

    Selected AceView cDNA sequences (see all 169):

    CA448208 AL519775 BM716769 CB156058 BM716899 AI298343 CD368462 CA489117 
    AI248038 BI255383 AI311669 BU607470 AA128559 Z42635 AI350653 AA459210 
    AA406286 NM_020395 BX106664 AA814728 BM681396 CA414663 AI278012 BU738485 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    INTS12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGATGGGAT
    INTS12 Expression
    About this image

    INTS12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    INTS12 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.480454
        Custom PCR Arrays for INTS12
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTS12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for INTS12 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ints121 , 5 integrator complex subunit 121, 5 88.15(n)1
    91.33(a)1
      3 (61.56 cM)5
    717931  NM_027927.31  NP_082203.11 
     1330918405 
    chicken
    (Gallus gallus)
    Aves INTS121 integrator complex subunit 12 74.31(n)
    77.9(a)
      422537  XM_420500.4  XP_420500.3 
    lizard
    (Anolis carolinensis)
    Reptilia INTS126
    integrator complex subunit 12
    79(a)
    1 ↔ 1
    GL343375.1(272083-284287)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.136192 Xenopus laevis transcribed sequence with weak similarity more 74.94(n)    BJ618403.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003347131 integrator complex subunit 12-like 59.7(n)
    63.6(a)
      100334713  XM_005159904.1  XP_005159961.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta IntS126
    Integrator 12
    27(a)
    1 ↔ 1
    3R(22689120-22690289)


    ENSEMBL Gene Tree for INTS12 (if available)
    TreeFam Gene Tree for INTS12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for INTS12 (see all 474)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1477797651,2
    --106603539(+) GCCACA/GTAAGG 2 -- int10--------
    rs766124851,2
    C,F--106603753(+) TAATAT/CTTAGC 2 -- int12Minor allele frequency- C:0.12WA NA 238
    rs798665481,2
    C--106603861(+) AGGCTA/GATATG 2 -- ut310--------
    rs342345811,2
    C,F--106603935(+) ATCTGT/CAATCG 4 /L syn13Minor allele frequency- C:0.01NA WA 4730
    rs1451748071,2
    C,F--106604070(+) CCATTC/TCCACT 4 G syn12Minor allele frequency- T:0.00NA EU 5875
    rs1153026481,2
    C,F--106604164(+) TAAGGC/ACAGTT 4 /G /V mis13Minor allele frequency- A:0.00NA EU 5993
    rs353707431,2
    C,F--106604190(+) GGTGGA/GGGTGG 4 P syn15Minor allele frequency- G:0.05NA EU 6073
    rs100081581,2
    C,H--106604223(+) GTGCTG/ATTATT 4 /N syn1 ese36Minor allele frequency- A:0.00NS EA NA 424
    rs1849868131,2
    C--106604227(+) TGTTAC/TTGGAA 4 N S mis10--------
    rs1476141651,2
    C--106604308(+) CTGACA/GAAGTA 4 S L mis10--------

    HapMap Linkage Disequilibrium report for INTS12 (106603784 - 106817143 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for INTS12:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv879699CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing INTS12
    DNA2.0 Custom Variant and Variant Library Synthesis for INTS12

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611355    OMIM disorders: --


    Find genes that share disorders with INTS12           About GenesLikeMe

    1 Novoseek inferred disease relationship for INTS12 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenocarcinoma 9.61 3 9352443 (1), 9553811 (1)

    Genetic Association Database (GAD): INTS12
    Human Genome Epidemiology (HuGE) Navigator: INTS12 (2 documents)

    Export disorders for INTS12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for INTS12 gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with INTS12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PubMed id 16239144)1, 2, 3 Baillat D....Shiekhattar R. (Cell 2005)
    2. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PubMed id 20332099)1, 4 Kalsi G....Riley B.P. (Hum. Mol. Genet. 2010)
    3. Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. (PubMed id 20010835)1, 4 Hancock D.B....London S.J. (Nat. Genet. 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Gene network analysis in a pediatric cohort identifies novel lung function genes. (PubMed id 24023788)1 Ong B.A....Hakonarson H. (PLoS ONE 2013)
    6. Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. (PubMed id 23284291)1 Hancock D.B....London S.J. (PLoS Genet. 2012)
    7. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    8. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    9. Comparative proteomic analysis identifies a role for SUMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (Sci Signal 2011)
    10. Purification and identification of endogenous polySUMO conjugates. (PubMed id 21252943)1 Bruderer R....Hay R.T. (EMBO Rep. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57117 HGNC: 25067 AceView: LOC57117 Ensembl:ENSG00000138785 euGenes: HUgn57117
    ECgene: INTS12 H-InvDB: INTS12

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for INTS12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for INTS12 gene:
    Search GeneIP for patents involving INTS12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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