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Aliases for INTS10 Gene

Aliases for INTS10 Gene

  • Integrator Complex Subunit 10 2 3 5
  • C8orf35 3 4
  • INT10 3 4
  • Chromosome 8 Open Reading Frame 35 2

External Ids for INTS10 Gene

Previous HGNC Symbols for INTS10 Gene

  • C8orf35

Previous GeneCards Identifiers for INTS10 Gene

  • GC08P019674
  • GC08P018215

Summaries for INTS10 Gene

Entrez Gene Summary for INTS10 Gene

  • INTS10 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]

GeneCards Summary for INTS10 Gene

INTS10 (Integrator Complex Subunit 10) is a Protein Coding gene. Among its related pathways are RNA polymerase II transcribes snRNA genes and Gene Expression.

UniProtKB/Swiss-Prot for INTS10 Gene

  • Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex (PubMed:23904267).

Additional gene information for INTS10 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INTS10 Gene

Genomics for INTS10 Gene

Regulatory Elements for INTS10 Gene

Enhancers for INTS10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H020196 1.7 FANTOM5 ENCODE dbSUPER 11.6 +380.8 380820 2 HDGF MLX ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF207 ZNF143 SP3 ATP6V1B2 INTS10 GC08P020230
GH08H020310 0.9 ENCODE 20.2 +493.9 493860 1 ZSCAN4 INSM2 KLF17 GLI4 ZNF2 ZEB1 ZNF366 ZSCAN5C ZNF391 ATF7 INTS10 LOC105379314 LZTS1-AS1 ENSG00000254026 LOC101929172 RNU6-892P LZTS1
GH08H020276 1.3 Ensembl ENCODE dbSUPER 11.6 +460.2 460214 1 ZNF766 ELK1 CAVIN1 ZBTB11 USF2 HDAC8 MEF2D ZNF589 NR2C1 KLF1 LZTS1 INTS10 RNU6-892P LZTS1-AS1 RNA5SP257
GH08H019455 1.4 FANTOM5 Ensembl ENCODE 10.3 -358.0 -357962 7 ELF3 FOXA2 ATF1 MLX RARA ATF7 CREM THAP11 KLF11 HMG20B CSGALNACT1 INTS10 LOC102724881 LOC105379308
GH08H019408 1.4 FANTOM5 Ensembl ENCODE 10.3 -408.0 -408029 2 CTCF ATF1 NFIB ZSCAN4 ZNF384 RAD21 ZFHX2 ZBTB48 SMC3 ZNF600 CSGALNACT1 INTS10 SH2D4A LOC102724881 LOC105379308
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around INTS10 on UCSC Golden Path with GeneCards custom track

Promoters for INTS10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000221857 360 2201 HDGF FOXA2 PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1

Genomic Location for INTS10 Gene

Chromosome:
8
Start:
19,817,140 bp from pter
End:
19,852,083 bp from pter
Size:
34,944 bases
Orientation:
Plus strand

Genomic View for INTS10 Gene

Genes around INTS10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INTS10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INTS10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INTS10 Gene

Proteins for INTS10 Gene

  • Protein details for INTS10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVR2-INT10_HUMAN
    Recommended name:
    Integrator complex subunit 10
    Protein Accession:
    Q9NVR2
    Secondary Accessions:
    • Q6IA93
    • Q7L538
    • Q7L8C8
    • Q9H3W8

    Protein attributes for INTS10 Gene

    Size:
    710 amino acids
    Molecular mass:
    82236 Da
    Quaternary structure:
    • Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12. Interacts with POLR2A.
    SequenceCaution:
    • Sequence=BAA91687.1; Type=Frameshift; Positions=90; Evidence={ECO:0000305};

neXtProt entry for INTS10 Gene

Post-translational modifications for INTS10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for INTS10 Gene

Domains & Families for INTS10 Gene

Gene Families for INTS10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for INTS10 Gene

Suggested Antigen Peptide Sequences for INTS10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NVR2

UniProtKB/Swiss-Prot:

INT10_HUMAN :
  • Belongs to the Integrator subunit 10 family.
Family:
  • Belongs to the Integrator subunit 10 family.
genes like me logo Genes that share domains with INTS10: view

Function for INTS10 Gene

Molecular function for INTS10 Gene

UniProtKB/Swiss-Prot Function:
Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex (PubMed:23904267).

Phenotypes From GWAS Catalog for INTS10 Gene

Gene Ontology (GO) - Molecular Function for INTS10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 contributes_to protein binding IPI 16239144
genes like me logo Genes that share ontologies with INTS10: view

Phenotypes for INTS10 Gene

GenomeRNAi human phenotypes for INTS10:
genes like me logo Genes that share phenotypes with INTS10: view

Animal Model Products

CRISPR Products

miRNA for INTS10 Gene

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for INTS10
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for INTS10 Gene

Localization for INTS10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for INTS10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for INTS10 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for INTS10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 23904267
GO:0005654 nucleoplasm TAS --
GO:0032039 integrator complex IEA,IDA 16239144
genes like me logo Genes that share ontologies with INTS10: view

Pathways & Interactions for INTS10 Gene

genes like me logo Genes that share pathways with INTS10: view

Pathways by source for INTS10 Gene

2 Reactome pathways for INTS10 Gene

Gene Ontology (GO) - Biological Process for INTS10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016180 snRNA processing IEA,IDA 16239144
GO:0042795 snRNA transcription from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with INTS10: view

No data available for SIGNOR curated interactions for INTS10 Gene

Drugs & Compounds for INTS10 Gene

(1) Additional Compounds for INTS10 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with INTS10: view

Transcripts for INTS10 Gene

Unigene Clusters for INTS10 Gene

Integrator complex subunit 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for INTS10
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for INTS10 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^
SP1: - - - - - -
SP2: - -
SP3: - - -
SP4:
SP5: - -
SP6:
SP7: - - - - - -
SP8: - -
SP9:
SP10: - -
SP11:
SP12:
SP13: -
SP14:
SP15: - - - -

ExUns: 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b · 19c
SP1: - - - -
SP2: - -
SP3:
SP4: -
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for INTS10 Gene

GeneLoc Exon Structure for
INTS10
ECgene alternative splicing isoforms for
INTS10

Expression for INTS10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for INTS10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for INTS10 Gene

This gene is overexpressed in Cervix (44.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for INTS10 Gene



Protein tissue co-expression partners for INTS10 Gene

NURSA nuclear receptor signaling pathways regulating expression of INTS10 Gene:

INTS10

SOURCE GeneReport for Unigene cluster for INTS10 Gene:

Hs.512627

Evidence on tissue expression from TISSUES for INTS10 Gene

  • Lung(4.3)
  • Lymph node(4.3)
  • Nervous system(3.9)
genes like me logo Genes that share expression patterns with INTS10: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for INTS10 Gene

Orthologs for INTS10 Gene

This gene was present in the common ancestor of animals.

Orthologs for INTS10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INTS10 33
  • 95.82 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 95 (a)
OneToMany
-- 34
  • 91 (a)
OneToMany
dog
(Canis familiaris)
Mammalia INTS10 33 34
  • 92.44 (n)
oppossum
(Monodelphis domestica)
Mammalia INTS10 34
  • 90 (a)
OneToOne
cow
(Bos Taurus)
Mammalia INTS10 33 34
  • 88.54 (n)
mouse
(Mus musculus)
Mammalia Ints10 33 16 34
  • 87.32 (n)
rat
(Rattus norvegicus)
Mammalia Ints10 33
  • 87.28 (n)
chicken
(Gallus gallus)
Aves INTS10 33 34
  • 81.55 (n)
lizard
(Anolis carolinensis)
Reptilia INTS10 34
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ints10 33
  • 74.18 (n)
Str.11986 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.15816 33
zebrafish
(Danio rerio)
Actinopterygii ints10 33 34
  • 66.01 (n)
Dr.28211 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003262 33
  • 43.67 (n)
fruit fly
(Drosophila melanogaster)
Insecta IntS10 33 34
  • 42.55 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 30 (a)
OneToMany
-- 34
  • 26 (a)
OneToMany
Species where no ortholog for INTS10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for INTS10 Gene

ENSEMBL:
Gene Tree for INTS10 (if available)
TreeFam:
Gene Tree for INTS10 (if available)

Paralogs for INTS10 Gene

No data available for Paralogs for INTS10 Gene

Variants for INTS10 Gene

Sequence variations from dbSNP and Humsavar for INTS10 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000262678 -- 19,833,410(+) AGTGC(A/C)CGTTT intron-variant
rs1000281593 -- 19,851,589(+) AGCAG(C/T)GATCA intron-variant
rs1000312488 -- 19,839,710(+) AACAA(-/AAAC)AAAAA intron-variant
rs1000411547 -- 19,845,868(+) TTGTA(A/G)ATGTC intron-variant, downstream-variant-500B
rs1000504130 -- 19,824,498(+) AAAAA(-/AG)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for INTS10 Gene

Variant ID Type Subtype PubMed ID
esv3891372 CNV gain 25118596
nsv522185 CNV gain 19592680
nsv610759 CNV gain 21841781

Variation tolerance for INTS10 Gene

Residual Variation Intolerance Score: 9.02% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.69; 32.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for INTS10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
INTS10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INTS10 Gene

Disorders for INTS10 Gene

Relevant External Links for INTS10

Genetic Association Database (GAD)
INTS10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
INTS10

No disorders were found for INTS10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for INTS10 Gene

Publications for INTS10 Gene

  1. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PMID: 16239144) Baillat D … Shiekhattar R (Cell 2005) 2 3 4 60
  2. Nuclear-localized Asunder regulates cytoplasmic dynein localization via its role in the integrator complex. (PMID: 23904267) Jodoin JN … Lee LA (Molecular biology of the cell 2013) 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60

Products for INTS10 Gene

Sources for INTS10 Gene

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