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INTS10 Gene

protein-coding   GIFtS: 50
GCID: GC08P019674

Integrator Complex Subunit 10

(Previous name: chromosome 8 open reading frame 35)
(Previous symbol: C8orf35)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Integrator Complex Subunit 101 2
C8orf351 2 3
INT102 5
Chromosome 8 Open Reading Frame 351
Int103

External Ids:    HGNC: 255481   Entrez Gene: 551742   Ensembl: ENSG000001046137   OMIM: 6113535   UniProtKB: Q9NVR23   

Export aliases for INTS10 gene to outside databases

Previous GC identifers: GC08P019721 GC08P018215


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for INTS10 Gene:
INTS10 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II
large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM
180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 (PubMed 16239144)).(supplied by OMIM, Mar 2008)

GeneCards Summary for INTS10 Gene:
INTS10 (integrator complex subunit 10) is a protein-coding gene. Diseases associated with INTS10 include neonatal ovarian cyst, and ovarian cyst.

UniProtKB/Swiss-Prot: INT10_HUMAN, Q9NVR2
Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2
transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal
domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NT_167187.2  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the INTS10 gene promoter:
         HTF   CUTL1   Evi-1   Roaz   HNF-1A   AREB6   HNF-1   FOXO1a   MRF-2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidINTS10 promoter sequence
   Search Chromatin IP Primers for INTS10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat INTS10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21.3   Ensembl cytogenetic band:  8p21.3   HGNC cytogenetic band: 8p21.3

INTS10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INTS10 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P019674:  view genomic region     (about GC identifiers)

Start:
19,674,651 bp from pter      End:
19,709,594 bp from pter
Size:
34,944 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: INT10_HUMAN, Q9NVR2 (See protein sequence)
Recommended Name: Integrator complex subunit 10  
Size: 710 amino acids; 82236 Da
Subunit: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5,
INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12. Interacts with POLR2A
Sequence caution: Sequence=BAA91687.1; Type=Frameshift; Positions=90; Sequence=CAG33543.1; Type=Erroneous
initiation;
Secondary accessions: Q6IA93 Q7L538 Q7L8C8 Q9H3W8

Explore the universe of human proteins at neXtProt for INTS10: NX_Q9NVR2

Explore proteomics data for INTS10 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See INTS10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060612.2  
    ENSEMBL proteins: 
     ENSP00000381064   ENSP00000429011   ENSP00000430877   ENSP00000428107   ENSP00000430446  
     ENSP00000430704   ENSP00000429534   ENSP00000429117   ENSP00000428300   ENSP00000428608  
     ENSP00000428671  

    INTS10 Human Recombinant Protein Products:

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    Novus Biologicals INTS10 Lysate
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    Cloud-Clone Corp. Proteins for INTS10

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    INTS10 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026164 Int_cplx_su10

    Graphical View of Domain Structure for InterPro Entry Q9NVR2

    ProtoNet protein and cluster: Q9NVR2

    UniProtKB/Swiss-Prot: INT10_HUMAN, Q9NVR2
    Similarity: Belongs to the Integrator subunit 10 family


    INTS10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: INT10_HUMAN, Q9NVR2
    Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2
    transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal
    domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515contributes to protein binding IPI16239144
         
    INTS10 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for INTS10
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for INTS10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for INTS10
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for INTS10

    miRNA
    Products:
        
    miRTarBase miRNAs that target INTS10:
    hsa-mir-1229-3p (MIRT036281), hsa-mir-155-5p (MIRT021023), hsa-mir-34a-5p (MIRT047370), hsa-mir-455-3p (MIRT037912)

    Block miRNA regulation of human, mouse, rat INTS10 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate INTS10:
    hsa-miR-520d-5p hsa-miR-3613-3p hsa-miR-651 hsa-miR-524-5p hsa-miR-3662 hsa-miR-3121-3p hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidINTS10 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for INTS10
    Predesigned siRNA for gene silencing in human, mouse, rat INTS10

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for INTS10

    Clone
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    GenScript: all cDNA clones in your preferred vector: INTS10 (NM_018142)
    Sino Biological Human cDNA Clone for INTS10
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INTS10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INTS10

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for INTS10 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTS10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    INT10_HUMAN, Q9NVR2: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0032039integrator complex IDA16239144

    INTS10 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for INTS10
    Interactions:

        Search GeneGlobe Interaction Network for INTS10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for INTS10 (Q9NVR23 ENSP000003810644) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    INTS5Q6P9B93, ENSP000003278894I2D: score=1 STRING: ENSP00000327889
    INTS1Q8N2013, ENSP000003857224I2D: score=1 STRING: ENSP00000385722
    INTS3Q68E013, ENSP000003186414I2D: score=1 STRING: ENSP00000318641
    INTS6Q9UL033, ENSP000003102604I2D: score=1 STRING: ENSP00000310260
    RAF1P040493, ENSP000002518494I2D: score=3 STRING: ENSP00000251849
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016180snRNA processing IDA16239144

    INTS10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for INTS10 (INT10)

    1 Novoseek inferred chemical compound relationship for INTS10 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acetonitrile 18.1 1 11446650 (1)



    INTS10 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for INTS10 gene: 
    NM_018142.2  

    Unigene Cluster for INTS10:

    Integrator complex subunit 10
    Hs.512627  [show with all ESTs]
    Unigene Representative Sequence: NM_018142
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000397977(uc003wzj.3 uc022asn.1) ENST00000518424 ENST00000522114
    ENST00000520985 ENST00000521758 ENST00000523869 ENST00000522081 ENST00000523846
    ENST00000522806 ENST00000523143 ENST00000521357 ENST00000518799 ENST00000519493
    ENST00000520670 ENST00000521008 ENST00000523772 ENST00000520827 ENST00000607660

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat INTS10 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate INTS10:
    hsa-miR-520d-5p hsa-miR-3613-3p hsa-miR-651 hsa-miR-524-5p hsa-miR-3662 hsa-miR-3121-3p hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidINTS10 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for INTS10
    Predesigned siRNA for gene silencing in human, mouse, rat INTS10
    Clone
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    OriGene clones in human, mouse for INTS10 (see all 7)
    OriGene ORF clones in mouse, rat for INTS10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: INTS10 (NM_018142)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INTS10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INTS10
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for INTS10
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat INTS10
      QuantiTect SYBR Green Assays in human, mouse, rat INTS10
      QuantiFast Probe-based Assays in human, mouse, rat INTS10

    Additional mRNA sequence: 

    AK001431.1 AK092931.1 AL442078.1 BC001915.1 BC006209.2 BC051282.1 CR457262.1 

    17 DOTS entries:

    DT.86853013  DT.121473255  DT.100790454  DT.40204495  DT.70103735  DT.87046885  DT.40294731  DT.86853012 
    DT.95107986  DT.100790452  DT.40301370  DT.121473237  DT.121473261  DT.100028254  DT.121473247  DT.100028255 
    DT.95228022 

    Selected AceView cDNA sequences (see all 339):

    T32719 AI274857 BC051282 BQ229298 AA553813 N59872 CA950715 BQ927028 
    Z40261 CF141609 AI085028 AI889255 BX114206 AW340620 AI889517 AI635612 
    BM817537 BM905641 BF475865 AI431248 AA702327 AI754213 BQ219032 AI917191 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for INTS10 (see all 15)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^
    SP1:              -           -     -                                   -                                         -     -                                       
    SP2:                                                                                                                                      -     -               
    SP3:                                                                                                        -     -     -                                       
    SP4:                                                                                                                                                            
    SP5:                                                                                                              -     -                                       

    ExUns: 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b · 19c
    SP1:                          -     -                             -     -                     
    SP2:                          -     -                                                         
    SP3:                                                                                          
    SP4:                          -                                                               
    SP5:                                                                                          


    ECgene alternative splicing isoforms for INTS10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    INTS10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCACAGAGCC
    INTS10 Expression
    About this image


    INTS10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Intermediate Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             Mesonephric cells Mesonephros
             Mesonephros
     
     Kidney (Urinary System)
             Metanephros
     
     Gonad
             Mesonephric cells Mesonephros
     
     Testis (Reproductive System)
    INTS10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    INTS10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.512627
        Custom PCR Arrays for INTS10
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for INTS10
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat INTS10
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    QuantiFast Probe-based Assays in human, mouse, rat INTS10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTS10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for INTS10 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ints101 , 5 integrator complex subunit 101, 5 87.32(n)1
    95.77(a)1
      8 (33.88 cM)5
    708851  NM_027590.31  NP_081866.11 
     687939295 
    chicken
    (Gallus gallus)
    Aves INTS101 integrator complex subunit 10 81.55(n)
    90.7(a)
      422489  NM_001039297.1  NP_001034386.1 
    lizard
    (Anolis carolinensis)
    Reptilia INTS106
    integrator complex subunit 10
    84(a)
    1 ↔ 1
    6(58912473-58940401)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.158162 Xenopus laevis transcribed sequence with moderate similarity more 76.69(n)    BX846187.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.282112 Danio rerio hypothetical protein FLJ10569-like protein more 76.16(n)    AY391424.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta IntS101 Integrator 10 42.55(n)
    29.8(a)
      38444  NM_139573.2  NP_647830.1 


    ENSEMBL Gene Tree for INTS10 (if available)
    TreeFam Gene Tree for INTS10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for INTS10 (see all 904)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1899596531,2
    --19672960(+) GTAAAA/CTCACT 1 -- us2k10--------
    rs1816761471,2
    --19672999(+) AGATGC/GCAGCA 1 -- us2k10--------
    rs1871378971,2
    --19673050(+) ATCAAG/TAAGCT 1 -- us2k10--------
    rs170915451,2
    C,F,H--19673125(+) TTGGCA/TTCTAA 1 -- us2k110Minor allele frequency- T:0.09NA NS EA WA 800
    rs1919580071,2
    --19673151(+) TGGGCA/GCAATG 1 -- us2k10--------
    rs1833780111,2
    --19673222(+) GAGTTA/CAAGAA 1 -- us2k10--------
    rs1115532241,2
    C,F--19673286(+) CAGATG/ATGGTG 1 -- us2k12Minor allele frequency- A:0.11NA WA 120
    rs1135676511,2
    C,F--19673346(+) CTTGAA/GCCTGG 1 -- us2k11Minor allele frequency- G:0.00CSA 1
    rs1422844451,2
    C--19673432(+) CTCAA-/AAAC  
            
    AAACA
    1 -- us2k10--------
    rs1425775481,2
    C--19673606(+) TTTACC/TATTTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for INTS10 (19674651 - 19709594 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for INTS10:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv890625CNV Gain21882294
    nsv522185CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611353    OMIM disorders: --

    9 diseases for INTS10:    
    About MalaCards
    neonatal ovarian cyst    ovarian cyst    attention deficit hyperactivity disorder    lymphoblastic leukemia
    schizophrenia    lupus erythematosus    leukemia    thyroiditis
    malaria


    INTS10 for disorders           About GeneDecksing

    Genetic Association Database (GAD): INTS10

    Export disorders for INTS10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for INTS10 gene, integrated from 10 sources (see all 60):
    (articles sorted by number of sources associating them with INTS10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PubMed id 16239144)1, 2, 3 Baillat D....Shiekhattar R. (Cell 2005)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci. (PubMed id 23505323)1 Weissglas-Volkov D....Pajukanta P. (J. Med. Genet. 2013)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia. (PubMed id 22076464)1 Ellinghaus E....Franke A. (Leukemia 2012)
    7. Interactome study suggests multiple cellular functions of hepatoma-derived growth factor (HDGF). (PubMed id 21907836)1 Zhao J....Yang P. (J Proteomics 2011)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    10. Streamlined analysis schema for high-throughput identification of endogenous protein complexes. (PubMed id 20133760)1 Malovannaya A....Qin J. (Proc. Natl. Acad. Sci. U.S.A. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55174 HGNC: 25548 AceView: FLJ10569 Ensembl:ENSG00000104613 euGenes: HUgn55174
    ECgene: INTS10 H-InvDB: INTS10

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for INTS10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for INTS10 gene:
    Search GeneIP for patents involving INTS10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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