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Aliases for INTS10 Gene

Aliases for INTS10 Gene

  • Integrator Complex Subunit 10 2 3
  • INT10 3 4 6
  • C8orf35 3 4
  • Chromosome 8 Open Reading Frame 35 2

External Ids for INTS10 Gene

Previous HGNC Symbols for INTS10 Gene

  • C8orf35

Previous GeneCards Identifiers for INTS10 Gene

  • GC08P019674
  • GC08P018215

Summaries for INTS10 Gene

Entrez Gene Summary for INTS10 Gene

  • INTS10 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]

GeneCards Summary for INTS10 Gene

INTS10 (Integrator Complex Subunit 10) is a Protein Coding gene. Diseases associated with INTS10 include neonatal ovarian cyst.

UniProtKB/Swiss-Prot for INTS10 Gene

  • Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INTS10 Gene

Genomics for INTS10 Gene

Regulatory Elements for INTS10 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for INTS10 Gene

Start:
19,817,140 bp from pter
End:
19,852,083 bp from pter
Size:
34,944 bases
Orientation:
Plus strand

Genomic View for INTS10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for INTS10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INTS10 Gene

Proteins for INTS10 Gene

  • Protein details for INTS10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVR2-INT10_HUMAN
    Recommended name:
    Integrator complex subunit 10
    Protein Accession:
    Q9NVR2
    Secondary Accessions:
    • Q6IA93
    • Q7L538
    • Q7L8C8
    • Q9H3W8

    Protein attributes for INTS10 Gene

    Size:
    710 amino acids
    Molecular mass:
    82236 Da
    Quaternary structure:
    • Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12. Interacts with POLR2A.
    SequenceCaution:
    • Sequence=BAA91687.1; Type=Frameshift; Positions=90; Evidence={ECO:0000305}; Sequence=CAG33543.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for INTS10 Gene

Proteomics data for INTS10 Gene at MOPED

Post-translational modifications for INTS10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for INTS10 Gene

Domains for INTS10 Gene

Protein Domains for INTS10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for INTS10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NVR2

UniProtKB/Swiss-Prot:

INT10_HUMAN :
  • Q9NVR2
Family:
  • Belongs to the Integrator subunit 10 family.
genes like me logo Genes that share domains with INTS10: view

No data available for Gene Families for INTS10 Gene

Function for INTS10 Gene

Molecular function for INTS10 Gene

UniProtKB/Swiss-Prot Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes

Gene Ontology (GO) - Molecular Function for INTS10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 contributes_to protein binding IPI 16239144
genes like me logo Genes that share ontologies with INTS10: view

Animal Model Products

CRISPR Products

miRNA for INTS10 Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for INTS10 Gene

Localization for INTS10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for INTS10 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for INTS10 Gene COMPARTMENTS Subcellular localization image for INTS10 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for INTS10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032039 integrator complex IDA 16239144
genes like me logo Genes that share ontologies with INTS10: view

Pathways for INTS10 Gene

SuperPathways for INTS10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for INTS10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016180 snRNA processing IDA 16239144
genes like me logo Genes that share ontologies with INTS10: view

No data available for Pathways by source for INTS10 Gene

Compounds for INTS10 Gene

(1) Novoseek inferred chemical compound relationships for INTS10 Gene

Compound -log(P) Hits PubMed IDs
acetonitrile 18.1 1
genes like me logo Genes that share compounds with INTS10: view

Transcripts for INTS10 Gene

Unigene Clusters for INTS10 Gene

Integrator complex subunit 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for INTS10

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for INTS10

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for INTS10 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^
SP1: - - - - - -
SP2: - -
SP3: - - -
SP4:
SP5: - -
SP6:
SP7: - - - - - -
SP8: - -
SP9:
SP10: - -
SP11:
SP12:
SP13: -
SP14:
SP15: - - - -

ExUns: 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b · 19c
SP1: - - - -
SP2: - -
SP3:
SP4: -
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for INTS10 Gene

GeneLoc Exon Structure for
INTS10
ECgene alternative splicing isoforms for
INTS10

Expression for INTS10 Gene

mRNA expression in normal human tissues for INTS10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for INTS10 Gene

SOURCE GeneReport for Unigene cluster for INTS10 Gene Hs.512627

genes like me logo Genes that share expressions with INTS10: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for INTS10 Gene

Orthologs for INTS10 Gene

This gene was present in the common ancestor of animals.

Orthologs for INTS10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INTS10 35
  • 95.82 (n)
  • 95.16 (a)
cow
(Bos Taurus)
Mammalia INTS10 35
  • 88.54 (n)
  • 96.62 (a)
INTS10 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia INTS10 35
  • 92.44 (n)
  • 97.89 (a)
INTS10 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ints10 35
  • 87.32 (n)
  • 95.77 (a)
Ints10 16
Ints10 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia INTS10 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 95 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ints10 35
  • 87.28 (n)
  • 96.2 (a)
chicken
(Gallus gallus)
Aves INTS10 35
  • 81.55 (n)
  • 90.7 (a)
INTS10 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia INTS10 36
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15816 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ints10 35
  • 74.18 (n)
  • 81.97 (a)
Str.11986 35
zebrafish
(Danio rerio)
Actinopterygii Dr.28211 35
ints10 35
  • 66.01 (n)
  • 68.08 (a)
ints10 36
  • 67 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003262 35
  • 43.67 (n)
  • 28.71 (a)
fruit fly
(Drosophila melanogaster)
Insecta IntS10 35
  • 42.55 (n)
  • 29.8 (a)
IntS10 36
  • 25 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToMany
-- 36
  • 26 (a)
OneToMany
Species with no ortholog for INTS10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for INTS10 Gene

ENSEMBL:
Gene Tree for INTS10 (if available)
TreeFam:
Gene Tree for INTS10 (if available)

Paralogs for INTS10 Gene

No data available for Paralogs for INTS10 Gene

Variants for INTS10 Gene

Sequence variations from dbSNP and Humsavar for INTS10 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs2934 -- 19,834,515(+) TCTCA(A/C)GTAGA intron-variant
rs960724 -- 19,848,339(-) GCCCT(C/T)AGTGT intron-variant
rs1127115 -- 19,845,797(+) GATCA(A/G)GCACC reference, missense
rs1316738 -- 19,835,270(+) TTATA(A/G)TCGTT intron-variant
rs1561749 -- 19,833,629(+) TTCTG(C/T)TGTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for INTS10 Gene

Variant ID Type Subtype PubMed ID
nsv522185 CNV Gain 19592680
nsv890625 CNV Gain 21882294

Relevant External Links for INTS10 Gene

HapMap Linkage Disequilibrium report
INTS10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INTS10 Gene

Disorders for INTS10 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for INTS10 Gene including...

Search for INTS10 Gene in MalaCards »

Relevant External Links for INTS10

Genetic Association Database (GAD)
INTS10
genes like me logo Genes that share disorders with INTS10: view

No data available for UniProtKB/Swiss-Prot for INTS10 Gene

Publications for INTS10 Gene

  1. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PMID: 16239144) Baillat D. … Shiekhattar R. (Cell 2005) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  5. Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides. (PMID: 18193046) Kooner J.S. … Thompson J.F. (Nat. Genet. 2008) 3

Products for INTS10 Gene

Sources for INTS10 Gene

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