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INTS1 Gene

protein-coding   GIFtS: 49
GCID: GC07M001509

Integrator Complex Subunit 1

  Search for INTS1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Integrator Complex Subunit 11 2
INT12 5
KIAA14403 5
NET282
Int13

External Ids:    HGNC: 245551   Entrez Gene: 261732   Ensembl: ENSG000001648807   OMIM: 6113455   UniProtKB: Q8N2013   

Export aliases for INTS1 gene to outside databases

Previous GC identifer: GC07M001477


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for INTS1 Gene:
INTS1 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II
large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM
180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 (PubMed 16239144)).(supplied by OMIM, Mar 2008)

GeneCards Summary for INTS1 Gene:
INTS1 (integrator complex subunit 1) is a protein-coding gene.

UniProtKB/Swiss-Prot: INT1_HUMAN, Q8N201
Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2
transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal
domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007819.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the INTS1 gene promoter:
         GR   E2F-4   E2F-3a   E2F-5   E2F-2   CREB   E2F   E2F-1   deltaCREB   GR-alpha   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for INTS1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat INTS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.3   Ensembl cytogenetic band:  7p22.3   HGNC cytogenetic band: 7p22.3

INTS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INTS1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M001509:  view genomic region     (about GC identifiers)

Start:
1,509,913 bp from pter      End:
1,545,489 bp from pter
Size:
35,577 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 1,562,263-1,596,426     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: INT1_HUMAN, Q8N201 (See protein sequence)
Recommended Name: Integrator complex subunit 1  
Size: 2190 amino acids; 244297 Da
Subunit: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5,
INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12
Sequence caution: Sequence=AAQ88846.1; Type=Erroneous initiation;
Secondary accessions: A6NJ44 Q6NT70 Q6UX74 Q8WV40 Q96D36 Q9NTD1 Q9P2A8 Q9Y3W8

Explore the universe of human proteins at neXtProt for INTS1: NX_Q8N201

Explore proteomics data for INTS1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys1868
  • Modification sites at PhosphoSitePlus

  • See INTS1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001073922.2  
    ENSEMBL proteins: 
     ENSP00000385722   ENSP00000419206   ENSP00000374121  

    INTS1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for INTS1

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR016024 ARM-type_fold
     IPR022145 DUF3677

    Graphical View of Domain Structure for InterPro Entry Q8N201

    ProtoNet protein and cluster: Q8N201

    UniProtKB/Swiss-Prot: INT1_HUMAN, Q8N201
    Similarity: Belongs to the Integrator subunit 1 family


    Find genes that share domains with INTS1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: INT1_HUMAN, Q8N201
    Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2
    transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal
    domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
         
    Find genes that share ontologies with INTS1           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for INTS1:
     Big cells  Decreased BPV1 E2 protein expr  Increased HPV18 LCR reporter a  Wnt reporter downregulated 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ints1):
     embryogenesis  mortality/aging 

    Find genes that share phenotypes with INTS1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ints1tm1Mnkm for INTS1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for INTS1
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for INTS1

    miRNA
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    miRTarBase miRNAs that target INTS1:
    hsa-mir-769-5p (MIRT039214), hsa-mir-769-3p (MIRT039110), hsa-let-7b-5p (MIRT052201), hsa-mir-877-5p (MIRT037241), hsa-mir-615-3p (MIRT039713)

    Block miRNA regulation of human, mouse, rat INTS1 using miScript Target Protectors
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    INT1_HUMAN, Q8N201: Nucleus membrane; Single-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane3
    cytosol2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0016021integral component of membrane IEA--
    GO:0031965nuclear membrane IEA--
    GO:0032039integrator complex IDA16239144

    Find genes that share ontologies with INTS1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for INTS1
    Interactions:

        Search GeneGlobe Interaction Network for INTS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for INTS1 (Q8N2012, 3 ENSP000003857224) via UniProtKB, MINT, STRING, and/or I2D (see all 813)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP2R1AP301532, 3, ENSP000003248044MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000324804
    DEAF1O753982, 3, ENSP000003718464MINT-65633 I2D: score=4 STRING: ENSP00000371846
    INTS6Q9UL032, 3, ENSP000003102604MINT-7947479 I2D: score=1 STRING: ENSP00000310260
    INTS8Q75QN22, 3, ENSP000003432744MINT-7947479 I2D: score=1 STRING: ENSP00000343274
    INTS12Q96CB82, 3MINT-7945693 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001832blastocyst growth ----
    GO:0001833inner cell mass cell proliferation IEA--
    GO:0016180snRNA processing IDA16239144
    GO:0034474U2 snRNA 3'-end processing IEA--
    GO:0043066negative regulation of apoptotic process IEA--

    Find genes that share ontologies with INTS1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for INTS1 (INT1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for INTS1 gene: 
    NM_001080453.2  

    Unigene Cluster for INTS1:

    Integrator complex subunit 1
    Hs.532188  [show with all ESTs]
    Unigene Representative Sequence: NM_001080453
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000404767 ENST00000493446 ENST00000483196 ENST00000479671 ENST00000482994
    ENST00000468115(uc003skp.1) ENST00000496988 ENST00000493531 ENST00000389470(uc003skn.2 uc003skq.2)

    miRNA
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    GenScript: all cDNA clones in your preferred vector: INTS1 (NM_001080453)
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat INTS1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for INTS1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat INTS1
      QuantiTect SYBR Green Assays in human, mouse, rat INTS1
      QuantiFast Probe-based Assays in human, mouse, rat INTS1

    Additional mRNA sequence: 

    AB037861.1 AL050110.1 AL137358.1 AY358482.1 BC013367.2 BC018777.1 BC069262.1 

    14 DOTS entries:

    DT.99935062  DT.95315033  DT.101979732  DT.121065025  DT.115973  DT.100060153  DT.95340579  DT.100760073 
    DT.428925  DT.95102163  DT.95340578  DT.99963286  DT.115972  DT.91709838 

    Selected AceView cDNA sequences (see all 378):

    BU163632 BQ068727 AK128479 CA396632 AB037861 AW517360 BF511965 AI784139 
    BQ071036 AL042192 BU149897 AA329538 BM796837 BE222788 AA305929 BQ009201 
    BU844403 CR590499 AW026176 BM974159 AI870620 BF346658 BG468191 BU729456 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for INTS1 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^
    SP1:                                                                          -                                                                                 
    SP2:                                                                          -                                         -     -                                 
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 23a · 23b ^ 24 ^ 25a · 25b ^ 26 ^ 27a · 27b · 27c ^ 28a · 28b ^ 29 ^ 30 ^ 31 ^ 32a · 32b · 32c
    SP1:  -                                                           -                       -               
    SP2:  -                                                           -                       -               
    SP3:                                                                                                      
    SP4:                                                              -                                       
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for INTS1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    INTS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    INTS1 Expression
    About this image

    INTS1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    INTS1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.532188
        Custom PCR Arrays for INTS1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTS1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for INTS1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ints11 , 5 integrator complex subunit 11, 5 84.99(n)1
    90.32(a)1
      5 (78.80 cM)5
    685101  NM_026748.21  NP_081024.31 
     1397512825 
    chicken
    (Gallus gallus)
    Aves INTS11 integrator complex subunit 1 76.75(n)
    84.5(a)
      416461  XM_414768.4  XP_414768.4 
    lizard
    (Anolis carolinensis)
    Reptilia INTS16
    integrator complex subunit 1
    71(a)
    1 ↔ 1
    GL343327.1(954034-1035050)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.31032 Xenopus laevis transcribed sequence with moderate similarity more 74.1(n)    BX846214.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa55a062 Transcribed sequence with weak similarity to protein more 71.21(n)    57034902 
    fruit fly
    (Drosophila melanogaster)
    Insecta IntS11 Integrator 1 50.41(n)
    36.77(a)
      37840  NM_138031.2  NP_611875.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C06A5.16
    Protein C06A5.1 (C06A5.1) mRNA, complete cds
    18(a)
    1 ↔ 1
    I(6012058-6021983) WBGene00015499


    ENSEMBL Gene Tree for INTS1 (if available)
    TreeFam Gene Tree for INTS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for INTS1 gene
    2 SIMAP similar genes for INTS1 using alignment to 2 protein entries:     INT1_HUMAN (see all proteins):
    INT1    DKFZP586J0619

    Find genes that share paralogs with INTS1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for INTS1 (see all 1606)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs732658971,2
    C,F--1509618(+) AGGCCG/AGACTC 1 -- int12Minor allele frequency- A:0.08WA 120
    rs1495704061,2
    C--1509635(+) CAGAGA/GCCGAC 1 -- int10--------
    rs1842490561,2
    --1509638(+) AGGCCA/GACCCC 1 -- int10--------
    rs1170389951,2
    F--1509643(+) GACCCC/TGTGGG 1 -- int11Minor allele frequency- T:0.01NA 120
    rs1139437361,2
    C,F--1509665(+) AGGCCC/AGGCAG 1 -- int12Minor allele frequency- A:0.10WA 120
    rs1887173171,2
    --1509666(+) GGCCCA/GGCAGG 1 -- int10--------
    rs1433874361,2
    C--1509672(+) GCAGGA/GCCCAG 1 -- int10--------
    rs778421341,2
    C,F--1509688(+) GCACTC/AGACAG 1 -- int11Minor allele frequency- A:0.13WA 118
    rs286156041,2
    C,F--1509707(+) TGACGC/TGGGGC 1 -- int17Minor allele frequency- T:0.33WA NA CSA EA 365
    rs1811516211,2
    --1509708(+) GACGTA/GGGGCG 1 -- int10--------

    HapMap Linkage Disequilibrium report for INTS1 (1509913 - 1545489 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for INTS1 (see all 35):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2733766CNV Deletion23290073
    esv2733767CNV Deletion23290073
    esv2733765CNV Deletion23290073
    esv2733764CNV Deletion23290073
    esv2733768CNV Deletion23290073
    esv1010068CNV Insertion20482838
    nsv366643CNV Insertion16902084
    esv1688140CNV Insertion17803354
    esv1005556CNV Insertion20482838
    nsv830880CNV Loss17160897

    Human Gene Mutation Database (HGMD): INTS1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing INTS1
    DNA2.0 Custom Variant and Variant Library Synthesis for INTS1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611345    OMIM disorders: --


    Find genes that share disorders with INTS1           About GenesLikeMe


    Export disorders for INTS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for INTS1 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with INTS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PubMed id 16239144)1, 2, 3 Baillat D....Shiekhattar R. (Cell 2005)
    2. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)1, 2 Nusbaum C....Lander E.S. (Nature 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    5. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    6. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    7. Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C.... Cristea I.M. (Mol. Cell. Proteomics 2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (amp 2011)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26173 HGNC: 24555 AceView: MGC11257.1 Ensembl:ENSG00000164880 euGenes: HUgn26173
    ECgene: INTS1 H-InvDB: INTS1

    (According to HUGE)
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    HUGE: KIAA1440

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for INTS1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for INTS1 gene:
    Search GeneIP for patents involving INTS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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