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Aliases for INTS1 Gene

Aliases for INTS1 Gene

  • Integrator Complex Subunit 1 2 3
  • INT1 3 4 6
  • KIAA1440 4 6
  • NET28 3

External Ids for INTS1 Gene

Previous GeneCards Identifiers for INTS1 Gene

  • GC07M001477
  • GC07M001509

Summaries for INTS1 Gene

Entrez Gene Summary for INTS1 Gene

  • INTS1 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]

GeneCards Summary for INTS1 Gene

INTS1 (Integrator Complex Subunit 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for INTS1 Gene

  • Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INTS1 Gene

Genomics for INTS1 Gene

Regulatory Elements for INTS1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for INTS1 Gene

Start:
1,470,277 bp from pter
End:
1,504,382 bp from pter
Size:
34,106 bases
Orientation:
Minus strand

Genomic View for INTS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for INTS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INTS1 Gene

Proteins for INTS1 Gene

  • Protein details for INTS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N201-INT1_HUMAN
    Recommended name:
    Integrator complex subunit 1
    Protein Accession:
    Q8N201
    Secondary Accessions:
    • A6NJ44
    • Q6NT70
    • Q6UX74
    • Q8WV40
    • Q96D36
    • Q9NTD1
    • Q9P2A8
    • Q9Y3W8

    Protein attributes for INTS1 Gene

    Size:
    2190 amino acids
    Molecular mass:
    244297 Da
    Quaternary structure:
    • Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12.
    SequenceCaution:
    • Sequence=AAQ88846.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for INTS1 Gene

Proteomics data for INTS1 Gene at MOPED

Post-translational modifications for INTS1 Gene

  • Ubiquitination at Lys1868
  • Modification sites at PhosphoSitePlus

Other Protein References for INTS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for INTS1 Gene

Domains for INTS1 Gene

Protein Domains for INTS1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for INTS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N201

UniProtKB/Swiss-Prot:

INT1_HUMAN :
  • Q8N201
Family:
  • Belongs to the Integrator subunit 1 family.
genes like me logo Genes that share domains with INTS1: view

No data available for Gene Families for INTS1 Gene

Function for INTS1 Gene

Molecular function for INTS1 Gene

UniProtKB/Swiss-Prot Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes

Gene Ontology (GO) - Molecular Function for INTS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
genes like me logo Genes that share ontologies with INTS1: view
genes like me logo Genes that share phenotypes with INTS1: view

Animal Models for INTS1 Gene

MGI Knock Outs for INTS1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for INTS1 Gene

Localization for INTS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for INTS1 Gene

Nucleus membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for INTS1 Gene COMPARTMENTS Subcellular localization image for INTS1 gene
Compartment Confidence
nucleus 5
plasma membrane 3
cytosol 2

Gene Ontology (GO) - Cellular Components for INTS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
GO:0031965 nuclear membrane IEA --
GO:0032039 integrator complex IDA 16239144
genes like me logo Genes that share ontologies with INTS1: view

Pathways for INTS1 Gene

SuperPathways for INTS1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for INTS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001832 blastocyst growth --
GO:0001833 inner cell mass cell proliferation IEA --
GO:0016180 snRNA processing IDA 16239144
GO:0034474 U2 snRNA 3-end processing IEA --
GO:0043066 negative regulation of apoptotic process --
genes like me logo Genes that share ontologies with INTS1: view

No data available for Pathways by source for INTS1 Gene

Transcripts for INTS1 Gene

Unigene Clusters for INTS1 Gene

Integrator complex subunit 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for INTS1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for INTS1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for INTS1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^
SP1: -
SP2: - - -
SP3:
SP4:
SP5:
SP6:

ExUns: 23a · 23b ^ 24 ^ 25a · 25b ^ 26 ^ 27a · 27b · 27c ^ 28a · 28b ^ 29 ^ 30 ^ 31 ^ 32a · 32b · 32c
SP1: - - -
SP2: - - -
SP3:
SP4: -
SP5:
SP6:

Relevant External Links for INTS1 Gene

GeneLoc Exon Structure for
INTS1
ECgene alternative splicing isoforms for
INTS1

Expression for INTS1 Gene

mRNA expression in normal human tissues for INTS1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for INTS1 Gene

SOURCE GeneReport for Unigene cluster for INTS1 Gene Hs.532188

genes like me logo Genes that share expressions with INTS1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for INTS1 Gene

Orthologs for INTS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for INTS1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia INTS1 35
  • 86.56 (n)
  • 88.84 (a)
INTS1 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia INTS1 35
  • 86.51 (n)
  • 90.67 (a)
INTS1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ints1 35
  • 84.99 (n)
  • 90.32 (a)
Ints1 16
Ints1 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia INTS1 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia INTS1 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ints1 35
  • 84.59 (n)
  • 89.77 (a)
chicken
(Gallus gallus)
Aves INTS1 35
  • 76.75 (n)
  • 84.5 (a)
INTS1 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia INTS1 36
  • 71 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3103 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ints1 35
  • 71.33 (n)
  • 80.65 (a)
Str.9190 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12772 35
zebrafish
(Danio rerio)
Actinopterygii ints1 35
  • 71.27 (n)
  • 74.54 (a)
ints1 36
  • 74 (a)
OneToOne
wufa55a06 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008047 35
  • 51.66 (n)
  • 38.46 (a)
fruit fly
(Drosophila melanogaster)
Insecta IntS1 35
  • 50.41 (n)
  • 36.77 (a)
IntS1 36
  • 32 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C06A5.1 36
  • 18 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
OneToOne
Species with no ortholog for INTS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for INTS1 Gene

ENSEMBL:
Gene Tree for INTS1 (if available)
TreeFam:
Gene Tree for INTS1 (if available)

Paralogs for INTS1 Gene

Selected SIMAP similar genes for INTS1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with INTS1: view

No data available for Paralogs for INTS1 Gene

Variants for INTS1 Gene

Sequence variations from dbSNP and Humsavar for INTS1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs11774 -- 1,473,591(-) CCTTC(C/T)TGCAG reference, synonymous-codon
rs732491 -- 1,494,409(-) GCCCC(A/G)TGGGT intron-variant
rs732492 -- 1,494,230(-) TGAGG(A/G)CAAGA intron-variant
rs745563 -- 1,506,218(+) GGCGC(A/G)GATCC upstream-variant-2KB
rs750005 -- 1,499,241(+) CGGGC(A/G)GGCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for INTS1 Gene

Variant ID Type Subtype PubMed ID
nsv887128 CNV Loss 21882294
nsv471182 CNV Loss 18288195
dgv2045e1 CNV Complex 17122850
dgv7088n71 CNV Loss 21882294
dgv7090n71 CNV Loss 21882294
dgv7092n71 CNV Loss 21882294
dgv7093n71 CNV Loss 21882294
nsv830878 CNV Loss 17160897
dgv7095n71 CNV Loss 21882294
dgv7096n71 CNV Loss 21882294
nsv521100 CNV Loss 19592680
nsv464247 CNV Loss 19166990
dgv7097n71 CNV Loss 21882294
dgv7098n71 CNV Loss 21882294
nsv823970 CNV Gain 20364138
nsv8029 CNV Gain+Loss 18304495
nsv887215 CNV Gain+Loss 21882294
dgv7099n71 CNV Loss 21882294
nsv887218 CNV Gain+Loss 21882294
nsv887219 CNV Loss 21882294
dgv7100n71 CNV Loss 21882294
esv2733764 CNV Deletion 23290073
nsv887221 CNV Gain 21882294
esv1010068 CNV Insertion 20482838
nsv366643 CNV Insertion 16902084
esv1005556 CNV Insertion 20482838
esv1688140 CNV Insertion 17803354
nsv830879 CNV Gain+Loss 17160897
nsv830880 CNV Loss 17160897
esv2733765 CNV Deletion 23290073
esv2733766 CNV Deletion 23290073
esv2733767 CNV Deletion 23290073
esv2733768 CNV Deletion 23290073
nsv887223 CNV Loss 21882294
nsv887224 CNV Loss 21882294

Relevant External Links for INTS1 Gene

HapMap Linkage Disequilibrium report
INTS1
Human Gene Mutation Database (HGMD)
INTS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INTS1 Gene

Disorders for INTS1 Gene

No disorders were found for INTS1 Gene.

No data available for UniProtKB/Swiss-Prot for INTS1 Gene

Publications for INTS1 Gene

  1. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PMID: 16239144) Baillat D. … Shiekhattar R. (Cell 2005) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  5. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 3 4

Products for INTS1 Gene

Sources for INTS1 Gene

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