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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

INTS1 Gene

protein-coding   GIFtS: 44
GCID: GC07M001477

Integrator Complex Subunit 1

  Search for INTS1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Integrator Complex Subunit 11 2
INT12
NET282
Int13
KIAA14403

External Ids:    HGNC: 245551   Entrez Gene: 261732   Ensembl: ENSG000001648807   OMIM: 6113455   UniProtKB: Q8N2013   

Export aliases for INTS1 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for INTS1 Gene:
INTS1 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II
large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM
180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 (PubMed 16239144)).(supplied by OMIM, Mar 2008)

GeneCards Summary for INTS1 Gene: 
INTS1 (integrator complex subunit 1) is a protein-coding gene.

UniProtKB/Swiss-Prot: INT1_HUMAN, Q8N201
Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2
transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal
domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the INTS1 gene promoter:
         GR   E2F-4   E2F-3a   E2F-5   E2F-2   CREB   E2F   E2F-1   deltaCREB   GR-alpha   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for INTS1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INTS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.3   Ensembl cytogenetic band:  7p22.3   HGNC cytogenetic band: 7p22.3

INTS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INTS1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M001477:  view genomic region     (about GC identifiers)

Start:
1,509,913 bp from pter      End:
1,545,489 bp from pter
Size:
35,577 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 1,562,263-1,596,426     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: INT1_HUMAN, Q8N201 (See protein sequence)
Recommended Name: Integrator complex subunit 1  
Size: 2190 amino acids; 244297 Da
Subunit: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5,
INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12
Subcellular location: Nucleus membrane; Single-pass membrane protein (Potential)
Sequence caution: Sequence=AAQ88846.1; Type=Erroneous initiation;
Secondary accessions: A6NJ44 Q6NT70 Q6UX74 Q8WV40 Q96D36 Q9NTD1 Q9P2A8 Q9Y3W8

Explore the universe of human proteins at neXtProt for INTS1: NX_Q8N201

Explore proteomics data for INTS1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N201

  • INTS1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    INTS1 Protein Expression
    REFSEQ proteins: NP_001073922.2  
    ENSEMBL proteins: 
     ENSP00000385722   ENSP00000419206   ENSP00000374121  

    Human Recombinant Protein Products for INTS1: 
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    OriGene Protein Over-expression Lysate for INTS1
    OriGene MassSpec for INTS1 
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    Novus Biologicals INTS1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for INTS1 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0016021integral to membrane IEA--
    GO:0031965nuclear membrane IEA--
    GO:0032039integrator complex IDA16239144

    INTS1 for ontologies           About GeneDecksing



    INTS1 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for INTS1 

    Assay Products for INTS1: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for INTS1 
    Cloud-Clone Corp. CLIAs for INTS1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR022145 DUF3677

    Graphical View of Domain Structure for InterPro Entry Q8N201

    ProtoNet protein and cluster: Q8N201

    UniProtKB/Swiss-Prot: INT1_HUMAN, Q8N201
    Similarity: Belongs to the Integrator subunit 1 family


    INTS1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: INT1_HUMAN, Q8N201
    Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2
    transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal
    domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
         
    INTS1 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for INTS1:
     Big cells  Decreased BPV1 E2 protein expr  Increased HPV18 LCR reporter a  Wnt reporter downregulated 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ints1):
     embryogenesis  mortality/aging 

    INTS1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ints1tm1Mnkm for INTS1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for INTS1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for INTS1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for INTS1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for INTS1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat INTS1
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for INTS1
    Sirion Biotech Customized adenovirus for overexpression of INTS1

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for INTS1 (see all 5)
    OriGene ORF clones in mouse, rat for INTS1
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    GenScript: all cDNA clones in your preferred vector: INTS1 (NM_001080453)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INTS1
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat INTS1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTS1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for INTS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/812 Interacting proteins for INTS1 (Q8N2012, 3 ENSP000003857224) via UniProtKB, MINT, STRING, and/or I2D (see all 812)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP2R1AP301532, 3, ENSP000003248044MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000324804
    DEAF1O753982, 3, ENSP000003718464MINT-65633 I2D: score=4 STRING: ENSP00000371846
    INTS6Q9UL032, 3, ENSP000003102604MINT-7947479 I2D: score=1 STRING: ENSP00000310260
    INTS8Q75QN22, 3, ENSP000003432744MINT-7947479 I2D: score=1 STRING: ENSP00000343274
    INTS12Q96CB82, 3MINT-7945693 I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001832blastocyst growth ----
    GO:0001833inner cell mass cell proliferation IEA--
    GO:0016180snRNA processing IDA16239144
    GO:0034474U2 snRNA 3'-end processing IEA--
    GO:0043066negative regulation of apoptotic process IEA--

    INTS1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for INTS1 (INT1)

    Search CenterWatch for drugs/clinical trials and news about INTS1 / INT1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for INTS1 gene: 
    NM_001080453.2  

    Unigene Cluster for INTS1:

    Integrator complex subunit 1
    Hs.532188  [show with all ESTs]
    Unigene Representative Sequence: NM_001080453
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000404767 ENST00000493446 ENST00000483196 ENST00000479671 ENST00000482994
    ENST00000468115(uc003skp.1) ENST00000496988 ENST00000493531 ENST00000389470(uc003skn.2 uc003skq.2)

    miRNA
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for INTS1
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    GenScript: all cDNA clones in your preferred vector: INTS1 (NM_001080453)
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat INTS1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for INTS1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INTS1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INTS1

    Additional mRNA sequence: 

    AB037861.1 AL050110.1 AL137358.1 AY358482.1 BC013367.2 BC018777.1 BC069262.1 

    14 DOTS entries:

    DT.99935062  DT.95315033  DT.101979732  DT.121065025  DT.115973  DT.100060153  DT.95340579  DT.100760073 
    DT.428925  DT.95102163  DT.95340578  DT.99963286  DT.115972  DT.91709838 

    24/378 AceView cDNA sequences (see all 378):

    AK128479 AI784139 AA329538 BX333425 CR600617 BG468191 BM796837 BF436031 
    AI470355 AI870620 BU844403 AW511078 BQ071036 BM974159 BQ940921 BC004286 
    AI146769 CA396632 AA305929 AW502462 BQ953580 BU149897 BU163632 AI192670 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for INTS1 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^
    SP1:                                                                          -                                                                                 
    SP2:                                                                          -                                         -     -                                 
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 23a · 23b ^ 24 ^ 25a · 25b ^ 26 ^ 27a · 27b · 27c ^ 28a · 28b ^ 29 ^ 30 ^ 31 ^ 32a · 32b · 32c
    SP1:  -                                                           -                       -               
    SP2:  -                                                           -                       -               
    SP3:                                                                                                      
    SP4:                                                              -                                       
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for INTS1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    INTS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    INTS1 Expression
    About this image


    See INTS1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for INTS1

    SOURCE GeneReport for Unigene cluster: Hs.532188
        SABiosciences Custom PCR Arrays for INTS1
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INTS1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTS1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for INTS1 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ints11 , 5 integrator complex subunit 11, 5 84.96(n)1
    90.32(a)1
      5 (78.80 cM)5
    685101  NM_026748.21  NP_081024.31 
     1397512825 
    chicken
    (Gallus gallus)
    Aves INTS11 integrator complex subunit 1 76.77(n)
    84.63(a)
      416461  XM_414768.3  XP_414768.3 
    lizard
    (Anolis carolinensis)
    Reptilia INTS16
    integrator complex subunit 1
    71(a)
    1 ↔ 1
    GL343327.1(954034-1035050)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.31032 Xenopus laevis transcribed sequence with moderate similarity more 74.1(n)    BX846214.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa55a062 Transcribed sequence with weak similarity to protein more 71.21(n)    57034902 
    fruit fly
    (Drosophila melanogaster)
    Insecta IntS11 Integrator 1 50.66(n)
    36.66(a)
      37840  NM_138031.2  NP_611875.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C06A5.16
    Protein C06A5.1
    18(a)
    1 ↔ 1
    I(6012058-6021983)


    ENSEMBL Gene Tree for INTS1 (if available)
    TreeFam Gene Tree for INTS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for INTS1 gene
    2 SIMAP similar genes for INTS1 using alignment to 2 protein entries:     INT1_HUMAN (see all proteins):
    INT1    DKFZP586J0619

    INTS1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1606 SNPs in INTS1 are shown (see all 1606)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs732658971,2
    C,F--1509618(+) AGGCCG/AGACTC 1 -- int12Minor allele frequency- A:0.08WA 120
    rs1495704061,2
    C--1509635(+) CAGAGA/GCCGAC 1 -- int10--------
    rs1842490561,2
    --1509638(+) AGGCCA/GACCCC 1 -- int10--------
    rs1170389951,2
    F--1509643(+) GACCCC/TGTGGG 1 -- int11Minor allele frequency- T:0.01NA 120
    rs1139437361,2
    C,F--1509665(+) AGGCCC/AGGCAG 1 -- int12Minor allele frequency- A:0.10WA 120
    rs1887173171,2
    --1509666(+) GGCCCA/GGCAGG 1 -- int10--------
    rs1433874361,2
    C--1509672(+) GCAGGA/GCCCAG 1 -- int10--------
    rs778421341,2
    C,F--1509688(+) GCACTC/AGACAG 1 -- int11Minor allele frequency- A:0.13WA 118
    rs286156041,2
    C,F--1509707(+) TGACGC/TGGGGC 1 -- int17Minor allele frequency- T:0.33WA NA CSA EA 365
    rs1811516211,2
    --1509708(+) GACGTA/GGGGCG 1 -- int10--------

    HapMap Linkage Disequilibrium report for INTS1 (1509913 - 1545489 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/35 variations for INTS1 (see all 35):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2733766CNV Deletion23290073
    esv2733767CNV Deletion23290073
    esv2733765CNV Deletion23290073
    esv2733764CNV Deletion23290073
    esv2733768CNV Deletion23290073
    esv1010068CNV Insertion20482838
    nsv366643CNV Insertion16902084
    esv1688140CNV Insertion17803354
    esv1005556CNV Insertion20482838
    nsv830880CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    INTS1 for disorders           About MalaCards
    OMIM gene information: 611345    OMIM disorders: --


    INTS1 for disorders           About GeneDecksing


    Export disorders for INTS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for INTS1 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with INTS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PubMed id 16239144)1, 2, 3 Baillat D....Shiekhattar R. (2005)
    2. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)1, 2 Nusbaum C....Lander E.S. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    5. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (2000)
    6. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (2013)
    7. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. Activity-based chemical proteomics accelerates inhibi tor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26173 HGNC: 24555 AceView: MGC11257.1 Ensembl:ENSG00000164880 euGenes: HUgn26173
    ECgene: INTS1 H-InvDB: INTS1

    (According to HUGE)
    About This Section
    HUGE: KIAA1440

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for INTS1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for INTS1 gene:
    Search GeneIP for patents involving INTS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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