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INSRR Gene

protein-coding   GIFtS: 62
GCID: GC01M156809

Insulin Receptor-Related Receptor

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Insulin Receptor-Related Receptor1 2
IRR2 3 5
IR-Related Receptor2 3
EC 2.7.10.13 8
Insulin Receptor-Related Protein2
EC 2.7.108

External Ids:    HGNC: 60931   Entrez Gene: 36452   Ensembl: ENSG000000276447   OMIM: 1476715   UniProtKB: P146163   

Export aliases for INSRR gene to outside databases

Previous GC identifers: GC01M154679 GC01M152575 GC01M153588 GC01M154027 GC01M153623 GC01M155076 GC01M128169


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for INSRR Gene:
INSRR (insulin receptor-related receptor) is a protein-coding gene. Diseases associated with INSRR include neurofibrosarcoma, and vesicoureteral reflux. GO annotations related to this gene include insulin receptor substrate binding and transmembrane receptor protein tyrosine kinase activity. An important paralog of this gene is ROR1.

UniProtKB/Swiss-Prot: INSRR_HUMAN, P14616
Function: Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by
increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB

Gene Wiki entry for INSRR Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the INSRR gene promoter:
         GR   p53   Sp1   AP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidINSRR promoter sequence
   Search Chromatin IP Primers for INSRR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat INSRR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21-q23   Ensembl cytogenetic band:  1q23.1   HGNC cytogenetic band: 1q21-q23

INSRR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INSRR gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M156809:  view genomic region     (about GC identifiers)

Start:
156,809,855 bp from pter      End:
156,828,810 bp from pter
Size:
18,956 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: INSRR_HUMAN, P14616 (See protein sequence)
Recommended Name: Insulin receptor-related protein precursor  
Size: 1297 amino acids; 143720 Da
Subunit: Probable tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to
the formation of the ligand-binding domain, while the beta chains carry the kinase domain
Secondary accessions: O60724 Q5VZS3

Explore the universe of human proteins at neXtProt for INSRR: NX_P14616

Explore proteomics data for INSRR at MOPED

Post-translational modifications: 

  • Autophosphorylated on tyrosine residues between pH 7.9 and pH 10.51
  • Glycosylation2 at Asn47, Asn311, Asn411, Asn492, Asn528, Asn616, Asn634, Asn756, Asn885, Asn898
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for INSRR (P14616) (see all 26)
     PESLKDG  RDLAARN  GVVLWEI  FGMVYEG 


    See INSRR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055030.1  
    ENSEMBL proteins: 
     ENSP00000357178  

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    Novus Biologicals INSRR Protein
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for INSRR

    INSRR Antibody Products:

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    ThermoFisher Antibodies for INSRR
    LSBio Antibodies in human, mouse, rat for INSRR

    INSRR Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for INSRR
    Cloud-Clone Corp. CLIAs for INSRR


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FN3: Fibronectin type III domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: Insulin receptor-related receptor
    Insulin receptor (InsR) family
    Insulin receptor family

    Selected InterPro protein domains (see all 15):
     IPR017441 Protein_kinase_ATP_BS
     IPR006212 Furin_repeat
     IPR028792 INSRR
     IPR003961 Fibronectin_type3
     IPR011009 Kinase-like_dom

    Graphical View of Domain Structure for InterPro Entry P14616

    ProtoNet protein and cluster: P14616

    5 Blocks protein domains:
    IPB000494 Epidermal growth-factor receptor (EGFR)
    IPB002011 Receptor tyrosine kinase
    IPB006211 Furin-like cysteine rich region
    IPB006212 Furin-like repeat
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: INSRR_HUMAN, P14616
    Domain: The extracellular domain is required for sensing alterations in external pH
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily
    Similarity: Contains 3 fibronectin type-III domains
    Similarity: Contains 1 protein kinase domain


    INSRR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: INSRR_HUMAN, P14616
    Function: Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by
    increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Genatlas biochemistry entry for INSRR:
    insulin receptor,related receptor,expressed in subsets of neuron,renal distal tubules,enterochromaffin-like cells
    of the fundic stomach and in the islets of pancreas,mutated in a region,involved in the susceptibility to type II
    non insulin dependent diabetes

         Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity ----
    GO:0004714transmembrane receptor protein tyrosine kinase activity NAS10226785
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
         
    INSRR for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for INSRR:
     Increased mitotic index  Synthetic lethal/sick with VHL 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Insrr):
     homeostasis/metabolism  mortality/aging  normal  renal/urinary system  reproductive system 

    INSRR for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Insrrtm1Dac for INSRR

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for INSRR
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for INSRR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for INSRR
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for INSRR

    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat INSRR

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for INSRR (see all 7)
    OriGene ORF clones in mouse, rat for INSRR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: INSRR (NM_014215)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INSRR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INSRR

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INSRR


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    INSRR_HUMAN, P14616: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    cytosol1
    endoplasmic reticulum1
    lysosome1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane NAS10226785
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----
    GO:0043235receptor complex IDA--

    INSRR for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for INSRR About   (see all 12)  
    See pathways by source

    SuperPathContained pathways About
    1GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    P2Y Receptor Signaling0.38
    2ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    3Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    4Actin Nucleation by ARP-WASP Complex
    Actin Nucleation and Branching0.66
    CDC42 Pathway0.41
    Actin Nucleation by ARP-WASP Complex0.66
    5Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for INSRR
        Akt Signaling Pathway

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for INSRR (see all 28)
        MAPK Signaling
    Paxillin Interactions
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling


    2 Kegg Pathways  (Kegg details for INSRR):
        Regulation of actin cytoskeleton
    Prostate cancer


    INSRR for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for INSRR
    Interactions:

        GeneGlobe Interaction Network for INSRR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for INSRR (P146163 ENSP000003571784) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KRT27Q7Z3Y83, ENSP000003016564I2D: score=1 STRING: ENSP00000301656
    INSRP062133, ENSP000003038304I2D: score=2 STRING: ENSP00000303830
    EGFENSP000002651714STRING: ENSP00000265171
    GRB2ENSP000003390074STRING: ENSP00000339007
    IGF1ENSP000003026654STRING: ENSP00000302665
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway NAS10226785
    GO:0018108peptidyl-tyrosine phosphorylation NAS10226785
    GO:0030238male sex determination IEA--
    GO:0031532actin cytoskeleton reorganization IDA--

    INSRR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for INSRR

    2 HMDB Compounds for INSRR    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    3 Novoseek inferred chemical compound relationships for INSRR gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphotyrosine 60.1 2 8071374 (1), 8916919 (1)
    tyrosine 53.1 19 8071374 (3), 10535406 (3), 8621681 (1), 10226785 (1) (see all 10)
    glucose 20.8 2 9681510 (1), 19383820 (1)



    INSRR for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for INSRR gene: 
    NM_014215.2  

    Unigene Cluster for INSRR:

    Insulin receptor-related receptor
    Hs.248138  [show with all ESTs]
    Unigene Representative Sequence: NM_014215
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000368195(uc010pht.2 uc009wsj.2)
    miRNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat INSRR
      QuantiFast Probe-based Assays in human, mouse, rat INSRR

    Additional mRNA sequence: 

    AF064078.1 AK310760.1 J05046.1 JQ991924.1 

    1 DOTS entry:

    DT.40124245 

    5 AceView cDNA sequences:

    J05046 NM_014215 AA706212 AL134339 AF064078 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    INSRR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATGGCGGGG
    INSRR Expression
    About this image

    INSRR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    INSRR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.248138
        Custom PCR Arrays for INSRR
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INSRR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for INSRR gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Insrr1 , 5 insulin receptor-related receptor1, 5 85.43(n)1
    89.13(a)1
      3 (38.70 cM)5
    239201  NM_011832.21  NP_035962.21 
     877969515 
    chicken
    (Gallus gallus)
    Aves LOC1008578111 insulin receptor-related protein-like 74.69(n)
    74.56(a)
      100857811  XM_004948197.1  XP_004948254.1 
    lizard
    (Anolis carolinensis)
    Reptilia INSRR6
    insulin receptor-related receptor
    65(a)
    1 ↔ 1
    GL343640.1(174478-220161)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC685852 hypothetical protein MGC68585 76.24(n)    BC060457.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG38373 insulin-like growth factor receptor 31(a)
    (best of 2)
      88D7   --
    worm
    (Caenorhabditis elegans)
    Secernentea daf-26
    Protein DAF-2, isoform b (daf-2) mRNA, complete cd...
    21(a)
    1 → many
    III(2995763-3028800) WBGene00000898


    ENSEMBL Gene Tree for INSRR (if available)
    TreeFam Gene Tree for INSRR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for INSRR gene
    ROR12  INSR2  ROS12  NTRK22  LTK2  IGF1R2  DDR12  NTRK32  
    ROR22  DDR22  MUSK2  ALK2  NTRK12  
    2 SIMAP similar genes for INSRR using alignment to 2 protein entries:     INSRR_HUMAN (see all proteins):
    IGF1R    INSR

    INSRR for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    8 SNPs for INSRR    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0414384
    A lung adenocarcinoma sample4--see VAR_0414382 E Q mis40--------
    VAR_0414414
    A glioblastoma multiforme sample4--see VAR_0414412 G E mis40--------
    rs559719001,2,4
    ----see VAR_0414352 mis40--------
    rs563778251,2,4
    ----see VAR_0414372 mis40--------
    rs559518401,2,4
    ----see VAR_0414362 mis40--------
    rs562521491,2,4
    ----see VAR_0414402 mis40--------
    rs560689371,2,4
    ----see VAR_0414392 mis40--------
    rs557577061,2,4
    ----see VAR_0414342 mis40--------

    HapMap Linkage Disequilibrium report for INSRR (156809855 - 156828810 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for INSRR:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831659CNV Loss17160897
    nsv831648CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing INSRR
    DNA2.0 Custom Variant and Variant Library Synthesis for INSRR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 147671    OMIM disorders: --

    9 diseases for INSRR:    
    About MalaCards
    neurofibrosarcoma    vesicoureteral reflux    neuroblastoma    prostate cancer
    prostatitis    adenocarcinoma    neuronitis    pancreatitis
    breast cancer

    1 disease from the University of Copenhagen DISEASES database for INSRR:
    Neurofibrosarcoma

    INSRR for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for INSRR gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 7 10535406 (3)

    Genetic Association Database (GAD): INSRR
    Human Genome Epidemiology (HuGE) Navigator: INSRR (3 documents)

    Export disorders for INSRR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for INSRR gene, integrated from 10 sources (see all 53):
    (articles sorted by number of sources associating them with INSRR)
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    1. Primary structure of a putative receptor for a ligand of the insulin family. (PubMed id 2768234)1, 2, 3 Shier P. and Watt V.M. (J. Biol. Chem. 1989)
    2. Localization of the insulin receptor-related receptor gene to human chromosome 1. (PubMed id 2249481)1, 3, 9 Shier P....Watt V.M. (Cytogenet. Cell Genet. 1990)
    3. Cloning and sequencing of the complete cDNA encoding the human insulin receptor related receptor. (PubMed id 10226785)1, 2, 9 Haenze J.... Kiess W. (Horm. Metab. Res. 1999)
    4. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)
    5. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)1, 4 Lu Y....Boer J.M. (J. Lipid Res. 2008)
    6. Correlation of type I insulin-like growth factor receptor (IGF-I-R) and insulin receptor-related receptor (IRR) messenger RNA levels in tumor cell lines from pediatric tumors of neuronal origin. (PubMed id 10535406)1, 9 Elmlinger M.W....Kiess W. (Regul. Pept. 1999)
    7. Coexpression of insulin receptor-related receptor and insulin-like growth factor 1 receptor correlates with enhanced apoptosis and dedifferentiation in human neuroblastomas. (PubMed id 14654552)1, 9 Weber A....Christiansen H. (Clin. Cancer Res. 2003)
    8. Characterization of a hybrid receptor formed by dimerization of the insulin receptor-related receptor (IRR) with the insulin receptor (IR): coexpression of cDNAs encoding human IRR and human IR in NIH-3T3 cells. (PubMed id 8916919)1, 9 Jui H.Y....Taylor S.I. (Biochemistry 1996)
    9. Characterization of the endogenous insulin receptor-related receptor in neuroblastomas. (PubMed id 7829525)1, 9 Kovacina K.S. and Roth R.A. (J. Biol. Chem. 1995)
    10. The insulin receptor-related receptor. Tissue expression, ligand binding specificity, and signaling capabilities. (PubMed id 1326521)1, 9 Zhang B. and Roth R.A. (J. Biol. Chem. 1992)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3645 HGNC: 6093 AceView: INSRR Ensembl:ENSG00000027644 euGenes: HUgn3645
    ECgene: INSRR Kegg: 3645 H-InvDB: INSRR

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for INSRR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for INSRR gene:
    Search GeneIP for patents involving INSRR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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