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Aliases for INSRR Gene

Aliases for INSRR Gene

  • Insulin Receptor Related Receptor 2 3 5
  • IR-Related Receptor 3 4
  • EC 2.7.10.1 4 61
  • IRR 3 4
  • Insulin Receptor-Related Protein 3
  • EC 2.7.10 61

External Ids for INSRR Gene

Previous GeneCards Identifiers for INSRR Gene

  • GC01M154679
  • GC01M152575
  • GC01M153588
  • GC01M154027
  • GC01M153623
  • GC01M155076
  • GC01M128169

Summaries for INSRR Gene

GeneCards Summary for INSRR Gene

INSRR (Insulin Receptor Related Receptor) is a Protein Coding gene. Diseases associated with INSRR include Podoconiosis and Neurofibrosarcoma. Among its related pathways are Activation of cAMP-Dependent PKA and mTOR signaling pathway (KEGG). GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is IGF1R.

UniProtKB/Swiss-Prot for INSRR Gene

  • Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.

Gene Wiki entry for INSRR Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INSRR Gene

Genomics for INSRR Gene

Regulatory Elements for INSRR Gene

Enhancers for INSRR Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F156765 1.4 Ensembl ENCODE 10.8 +91.1 91073 4.5 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 RRNAD1 PEAR1 KIAA0907 MRPL24 ENSG00000229961 ENSG00000233712 LRRC71 TSACC LOC246784 HDGF
GH01F156836 1.1 FANTOM5 ENCODE 12.3 +22.8 22785 0.2 PKNOX1 TBL1XR1 FEZF1 EBF1 RELA EED ZNF143 ETV6 CREM MAZ INSRR NTRK1 PEAR1 LRRC71 SH2D2A TSACC GC01M156858
GH01F156797 1.1 ENCODE 11.7 +61.5 61535 0.2 PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF766 ZNF143 PEAR1 MRPL24 INSRR LRRC71 HDGF PRCC LOC105371454 RRNAD1 ISG20L2 GC01P156814
GH01F156805 1 Ensembl ENCODE 12.2 +52.7 52650 1.0 PKNOX1 ZNF140 FEZF1 ZNF121 ZNF23 SCRT2 ZMIZ1 PRDM10 TSHZ1 ZEB2 RRNAD1 KIAA0907 INSRR PEAR1 LRRC71 ISG20L2 HDGF MRPL24 MIR765 ARHGEF11
GH01F156804 1 FANTOM5 Ensembl 12.2 +54.3 54318 1.0 CTCF ZNF384 ZNF316 ZBTB48 NFE2 MAFK MAZ ZBTB11 MAFG CEBPB MRPL24 INSRR PEAR1 LRRC71 ISG20L2 RRNAD1 HDGF MIR765 ARHGEF11 C1orf61
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around INSRR on UCSC Golden Path with GeneCards custom track

Promoters for INSRR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001750561 -282 201 SUZ12 MYNN CBX2 ZBTB7A ZFX EZH2
ENSR00001750562 -1482 601 HDAC1 TBL1XR1 SIN3A ZNF2 RAD21 ZEB1 GLIS2 ZNF366 ZNF143 EGR2

Genomic Location for INSRR Gene

Chromosome:
1
Start:
156,840,063 bp from pter
End:
156,859,018 bp from pter
Size:
18,956 bases
Orientation:
Minus strand

Genomic View for INSRR Gene

Genes around INSRR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INSRR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INSRR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INSRR Gene

Proteins for INSRR Gene

  • Protein details for INSRR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14616-INSRR_HUMAN
    Recommended name:
    Insulin receptor-related protein
    Protein Accession:
    P14616
    Secondary Accessions:
    • O60724
    • Q5VZS3

    Protein attributes for INSRR Gene

    Size:
    1297 amino acids
    Molecular mass:
    143720 Da
    Quaternary structure:
    • Probable tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain.

neXtProt entry for INSRR Gene

Selected DME Specific Peptides for INSRR Gene

P14616:
  • PESLKDG
  • RDLAARN
  • YALVIFEM
  • FFKNLKLIRGD
  • YVPDEWEV
  • DEWEVPR
  • GVVSQGQPT
  • GLLPVRWM
  • GVVLWEI
  • FGMVYEG
  • LFPNLAVIRG
  • KFVHRDLAARNCMV
  • HVVRLLGV
  • EGHLQILLMF
  • ECLGGCS
  • GDLKSHLRSLRP
  • TDYLLLFRVYGLESL
  • VRVEKNQELCHLSTIDWGLLQP
  • LKPWTQYA
  • TDYRCWTSSHCQ
  • EIADGMAYL
  • SSIFCHKCEGLCPKECKVGTKTIDS
  • FVHRDLA
  • LAALGFFY
  • QPYQGLSNE
  • IVGNKLGEECADVCPG

Post-translational modifications for INSRR Gene

  • Autophosphorylated on tyrosine residues between pH 7.9 and pH 10.5.
  • Glycosylation at Asn 47, Asn 311, Asn 411, Asn 492, Asn 528, Asn 616, Asn 634, Asn 756, Asn 885, and Asn 898
  • Modification sites at PhosphoSitePlus

Other Protein References for INSRR Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cloud-Clone Corp. Antibodies for INSRR
  • Santa Cruz Biotechnology (SCBT) Antibodies for INSRR

Domains & Families for INSRR Gene

Suggested Antigen Peptide Sequences for INSRR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P14616

UniProtKB/Swiss-Prot:

INSRR_HUMAN :
  • The extracellular domain is required for sensing alterations in external pH.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
Domain:
  • The extracellular domain is required for sensing alterations in external pH.
  • Contains 3 fibronectin type-III domains.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
genes like me logo Genes that share domains with INSRR: view

Function for INSRR Gene

Molecular function for INSRR Gene

GENATLAS Biochemistry:
insulin receptor,related receptor,expressed in subsets of neuron,renal distal tubules,enterochromaffin-like cells of the fundic stomach and in the islets of pancreas,mutated in a region,involved in the susceptibility to type II non insulin dependent diabetes
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function:
Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.

Enzyme Numbers (IUBMB) for INSRR Gene

Gene Ontology (GO) - Molecular Function for INSRR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA --
GO:0004714 transmembrane receptor protein tyrosine kinase activity NAS 10226785
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with INSRR: view
genes like me logo Genes that share phenotypes with INSRR: view

Animal Models for INSRR Gene

MGI Knock Outs for INSRR:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for INSRR

Flow Cytometry Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for INSRR Gene

Localization for INSRR Gene

Subcellular locations from UniProtKB/Swiss-Prot for INSRR Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for INSRR gene
Compartment Confidence
plasma membrane 5
extracellular 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for INSRR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IEA,NAS 10226785
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043235 receptor complex IDA 23382219
genes like me logo Genes that share ontologies with INSRR: view

Pathways & Interactions for INSRR Gene

genes like me logo Genes that share pathways with INSRR: view

Gene Ontology (GO) - Biological Process for INSRR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA,NAS 10226785
GO:0016310 phosphorylation IEA --
GO:0018108 peptidyl-tyrosine phosphorylation IEA --
GO:0030238 male sex determination IEA --
genes like me logo Genes that share ontologies with INSRR: view

No data available for SIGNOR curated interactions for INSRR Gene

Drugs & Compounds for INSRR Gene

(4) Drugs for INSRR Gene - From: DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Linsitinib Pharma Inhibition, inhibitor IGF1R/IR inhibitor,potent and novel, IGF1R inhibitor, Kinase Inhibitors 0

(2) Additional Compounds for INSRR Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with INSRR: view

Transcripts for INSRR Gene

mRNA/cDNA for INSRR Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for INSRR Gene

Insulin receptor-related receptor:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for INSRR

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for INSRR Gene

No ASD Table

Relevant External Links for INSRR Gene

GeneLoc Exon Structure for
INSRR
ECgene alternative splicing isoforms for
INSRR

Expression for INSRR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for INSRR Gene

mRNA differential expression in normal tissues according to GTEx for INSRR Gene

This gene is overexpressed in Kidney - Cortex (x10.4), Testis (x6.3), and Stomach (x4.3).

Protein differential expression in normal tissues from HIPED for INSRR Gene

This gene is overexpressed in Adipocyte (59.2) and Liver, secretome (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for INSRR Gene



Protein tissue co-expression partners for INSRR Gene

NURSA nuclear receptor signaling pathways regulating expression of INSRR Gene:

INSRR

SOURCE GeneReport for Unigene cluster for INSRR Gene:

Hs.248138
genes like me logo Genes that share expression patterns with INSRR: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for INSRR Gene

Orthologs for INSRR Gene

This gene was present in the common ancestor of animals.

Orthologs for INSRR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INSRR 34 35
  • 99.59 (n)
cow
(Bos Taurus)
Mammalia INSRR 34 35
  • 90.26 (n)
dog
(Canis familiaris)
Mammalia INSRR 34 35
  • 89.35 (n)
rat
(Rattus norvegicus)
Mammalia Insrr 34
  • 85.48 (n)
mouse
(Mus musculus)
Mammalia Insrr 34 16 35
  • 85.43 (n)
oppossum
(Monodelphis domestica)
Mammalia INSRR 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100857811 34
  • 74.69 (n)
INSRR 35
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia INSRR 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia insrr 34
  • 65.69 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68585 34
fruit fly
(Drosophila melanogaster)
Insecta CG3837 36 35
  • 31 (a)
CG10702 36
  • 26 (a)
worm
(Caenorhabditis elegans)
Secernentea daf-2 35
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
OneToMany
Species where no ortholog for INSRR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for INSRR Gene

ENSEMBL:
Gene Tree for INSRR (if available)
TreeFam:
Gene Tree for INSRR (if available)

Paralogs for INSRR Gene

Paralogs for INSRR Gene

(2) SIMAP similar genes for INSRR Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with INSRR: view

Variants for INSRR Gene

Sequence variations from dbSNP and Humsavar for INSRR Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_041438 A lung adenocarcinoma sample
VAR_041441 A glioblastoma multiforme sample
rs1007210 -- 156,860,743(+) AGAGG(G/T)GGGGG intron-variant, upstream-variant-2KB
rs10908521 -- 156,843,858(+) TATTT(C/T)TCAGC intron-variant
rs10908523 -- 156,860,426(+) GAGAA(C/T)GTTCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for INSRR Gene

Variant ID Type Subtype PubMed ID
nsv831648 CNV loss 17160897
nsv831659 CNV loss 17160897
nsv998265 CNV gain 25217958

Variation tolerance for INSRR Gene

Residual Variation Intolerance Score: 21.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.86; 83.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for INSRR Gene

Human Gene Mutation Database (HGMD)
INSRR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
INSRR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INSRR Gene

Disorders for INSRR Gene

MalaCards: The human disease database

(2) MalaCards diseases for INSRR Gene - From: DISEASES

Disorder Aliases PubMed IDs
podoconiosis
  • podoconiosis, susceptibility to
neurofibrosarcoma
  • neurosarcoma [obs]
- elite association - COSMIC cancer census association via MalaCards
Search INSRR in MalaCards View complete list of genes associated with diseases

Relevant External Links for INSRR

Genetic Association Database (GAD)
INSRR
Human Genome Epidemiology (HuGE) Navigator
INSRR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
INSRR
genes like me logo Genes that share disorders with INSRR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for INSRR Gene

Publications for INSRR Gene

  1. Cloning and sequencing of the complete cDNA encoding the human insulin receptor related receptor. (PMID: 10226785) Haenze J. … Kiess W. (Horm. Metab. Res. 1999) 3 4 22 64
  2. Localization of the insulin receptor-related receptor gene to human chromosome 1. (PMID: 2249481) Shier P. … Watt V.M. (Cytogenet. Cell Genet. 1990) 2 3 22 64
  3. Primary structure of a putative receptor for a ligand of the insulin family. (PMID: 2768234) Shier P. … Watt V.M. (J. Biol. Chem. 1989) 2 3 4 64
  4. Insulin receptor-related receptor as an extracellular alkali sensor. (PMID: 21641549) Deyev I.E. … Petrenko A.G. (Cell Metab. 2011) 3 4 64
  5. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C. … Hunter D.J. (Hum. Genet. 2010) 3 46 64

Products for INSRR Gene

Sources for INSRR Gene

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