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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

INSRR Gene

protein-coding   GIFtS: 63
GCID: GC01M156809

Insulin Receptor-Related Receptor

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Insulin Receptor-Related Receptor1 2
IRR2 3 5
IR-Related Receptor2 3
EC 2.7.10.13 8
Insulin Receptor-Related Protein2
EC 2.7.108

External Ids:    HGNC: 60931   Entrez Gene: 36452   Ensembl: ENSG000000276447   OMIM: 1476715   UniProtKB: P146163   

Export aliases for INSRR gene to outside databases

Previous GC identifers: GC01M154679 GC01M152575 GC01M153588 GC01M154027 GC01M153623 GC01M155076 GC01M128169


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for INSRR Gene: 
INSRR (insulin receptor-related receptor) is a protein-coding gene. Diseases associated with INSRR include neurofibrosarcoma, and vesicoureteral reflux, and among its related super-pathways are Ras Pathway and MAPK Signaling. GO annotations related to this gene include insulin receptor substrate binding and transmembrane receptor protein tyrosine kinase activity. An important paralog of this gene is ROR1.

UniProtKB/Swiss-Prot: INSRR_HUMAN, P14616
Function: Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by
increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB

Gene Wiki entry for INSRR Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the INSRR gene promoter:
         GR   p53   Sp1   AP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidINSRR promoter sequence
   Search SABiosciences Chromatin IP Primers for INSRR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INSRR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21-q23   Ensembl cytogenetic band:  1q23.1   HGNC cytogenetic band: 1q21-q23

INSRR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INSRR gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M156809:  view genomic region     (about GC identifiers)

Start:
156,809,855 bp from pter      End:
156,828,810 bp from pter
Size:
18,956 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: INSRR_HUMAN, P14616 (See protein sequence)
Recommended Name: Insulin receptor-related protein precursor  
Size: 1297 amino acids; 143720 Da
Subunit: Probable tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to
the formation of the ligand-binding domain, while the beta chains carry the kinase domain
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O60724 Q5VZS3

Explore the universe of human proteins at neXtProt for INSRR: NX_P14616

Explore proteomics data for INSRR at MOPED 

Post-translational modifications:

  • UniProtKB: Autophosphorylated on tyrosine residues between pH 7.9 and pH 10.5
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P14616

  • 4/26 DME Specific Peptides for INSRR (P14616) (see all 26)
     PESLKDG  RDLAARN  GVVLWEI  FGMVYEG 

    INSRR Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    INSRR Protein Expression
    REFSEQ proteins: NP_055030.1  
    ENSEMBL proteins: 
     ENSP00000357178  

    Human Recombinant Protein Products for INSRR: 
    EMD Millipore Purified and/or Recombinant INSRR Protein
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    GenScript Custom Purified and Recombinant Proteins Services for INSRR
    Novus Biologicals INSRR Protein
    Novus Biologicals INSRR Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for INSRR 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane NAS10226785
    GO:0016020membrane ----
    GO:0016021integral to membrane ----

    INSRR for ontologies           About GeneDecksing



    INSRR Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of INSRR
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    Cloud-Clone Corp. Antibodies for INSRR 
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    LSBio Antibodies in human, mouse, rat for INSRR 

    Assay Products for INSRR: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for INSRR 
    Cloud-Clone Corp. CLIAs for INSRR


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FN3: Fibronectin type III domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: Insulin receptor-related receptor 
    Insulin receptor (InsR) family
    Insulin receptor family

    5/14 InterPro protein domains (see all 14):
     IPR017441 Protein_kinase_ATP_BS
     IPR006212 Furin_repeat
     IPR003961 Fibronectin_type3
     IPR011009 Kinase-like_dom
     IPR002011 Tyr_kinase_rcpt_2_CS

    Graphical View of Domain Structure for InterPro Entry P14616

    ProtoNet protein and cluster: P14616

    5 Blocks protein domains:
    IPB000494 Epidermal growth-factor receptor (EGFR)
    IPB002011 Receptor tyrosine kinase
    IPB006211 Furin-like cysteine rich region
    IPB006212 Furin-like repeat
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: INSRR_HUMAN, P14616
    Domain: The extracellular domain is required for sensing alterations in external pH
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily
    Similarity: Contains 3 fibronectin type-III domains
    Similarity: Contains 1 protein kinase domain


    INSRR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: INSRR_HUMAN, P14616
    Function: Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by
    increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Genatlas biochemistry entry for INSRR:
    insulin receptor,related receptor,expressed in subsets of neuron,renal distal tubules,enterochromaffin-like cells
    of the fundic stomach and in the islets of pancreas,mutated in a region,involved in the susceptibility to type II
    non insulin dependent diabetes

         Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity ----
    GO:0004714transmembrane receptor protein tyrosine kinase activity NAS10226785
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
         
    INSRR for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for INSRR:
     Increased mitotic index  Synthetic lethal/sick with VHL 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Insrr):
     homeostasis/metabolism  mortality/aging  normal  renal/urinary system  reproductive system 

    INSRR for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Insrrtm1Dac for INSRR

       inGenious Targeting Laboratory - Custom generated mouse model solutions for INSRR 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for INSRR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for INSRR 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for INSRR 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat INSRR
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    Inhib. RNA
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: INSRR (NM_014215)
    Browse Sino Biological Human cDNA Clones
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                         Customized lentivirus expression plasmids for stable overexpression of INSRR 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INSRR


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for INSRR About   (see all 12)                                                                                              See pathways by source

    SuperPathContained pathways About
    1GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    P2Y Receptor Signaling0.38
    2Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    3Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    4Actin Nucleation by ARP-WASP Complex
    Actin Nucleation by ARP-WASP Complex0.66
    CDC42 Pathway0.41
    Actin Nucleation and Branching0.66
    5Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for INSRR
        Akt Signaling Pathway

    5/28 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for INSRR (see all 28)
        MAPK Signaling
    Paxillin Interactions
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling


    2         Kegg Pathways  (Kegg details for INSRR):
        Regulation of actin cytoskeleton
    Prostate cancer


    INSRR for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for INSRR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/20 Interacting proteins for INSRR (P146163 ENSP000003571784) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KRT27Q7Z3Y83, ENSP000003016564I2D: score=1 STRING: ENSP00000301656
    INSRP062133, ENSP000003038304I2D: score=2 STRING: ENSP00000303830
    EGFENSP000002651714STRING: ENSP00000265171
    GRB2ENSP000003390074STRING: ENSP00000339007
    IGF1ENSP000003026654STRING: ENSP00000302665
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway NAS10226785
    GO:0030238male sex determination IEA--
    GO:0031532actin cytoskeleton reorganization IDA--
    GO:0046777protein autophosphorylation IMP--

    INSRR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    INSRR for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for INSRR

    2 HMDB Compounds for INSRR    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    3 Novoseek inferred chemical compound relationships for INSRR gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphotyrosine 60.1 2 8071374 (1), 8916919 (1)
    tyrosine 53.1 19 8071374 (3), 10535406 (3), 8621681 (1), 10226785 (1) (see all 10)
    glucose 20.8 2 9681510 (1), 19383820 (1)

    Search CenterWatch for drugs/clinical trials and news about INSRR

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for INSRR gene: 
    NM_014215.2  

    Unigene Cluster for INSRR:

    Insulin receptor-related receptor
    Hs.248138  [show with all ESTs]
    Unigene Representative Sequence: NM_014215
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000368195(uc010pht.2 uc009wsj.2)
    miRNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INSRR

    Additional mRNA sequence: 

    AF064078.1 AK310760.1 J05046.1 JQ991924.1 

    1 DOTS entry:

    DT.40124245 

    5 AceView cDNA sequences:

    J05046 NM_014215 AL134339 AA706212 AF064078 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    INSRR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATGGCGGGG
    INSRR Expression
    About this image


    See INSRR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for INSRR

    SOURCE GeneReport for Unigene cluster: Hs.248138
        SABiosciences Custom PCR Arrays for INSRR
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INSRR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for INSRR gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Insrr1 , 5 insulin receptor-related receptor1, 5 85.43(n)1
    89.13(a)1
      3 (38.70 cM)5
    239201  NM_011832.21  NP_035962.21 
     877969515 
    chicken
    (Gallus gallus)
    Aves INSRR6
    Insulin receptor related tyrosine kinase; Uncharac...
    68(a)
    1 ↔ 1
    25(424856-433292)
    lizard
    (Anolis carolinensis)
    Reptilia INSRR6
    insulin receptor-related receptor
    62(a)
    1 ↔ 1
    GL343640.1(174478-220161)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC685852 hypothetical protein MGC68585 76.24(n)    BC060457.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG38373 insulin-like growth factor receptor 31(a)
    (best of 2)
      88D7   --
    worm
    (Caenorhabditis elegans)
    Secernentea daf-26
    Insulin-like receptor Insulin-like receptor subuni...
    21(a)
    1 → many
    III(2995763-3028800)


    ENSEMBL Gene Tree for INSRR (if available)
    TreeFam Gene Tree for INSRR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for INSRR gene
    ROR12  INSR2  ROS12  NTRK22  LTK2  IGF1R2  PTK72  DDR12  
    NTRK32  ROR22  DDR22  MUSK2  ALK2  NTRK12  
    2 SIMAP similar genes for INSRR using alignment to 2 protein entries:     INSRR_HUMAN (see all proteins):
    IGF1R    INSR

    INSRR for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    8 SNPs in INSRR are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0414384
    A lung adenocarcinoma sample4--see VAR_0414382 E Q mis40--------
    VAR_0414414
    A glioblastoma multiforme sample4--see VAR_0414412 G E mis40--------
    VAR_0414354
    ----see VAR_0414352 A V mis40--------
    VAR_0414374
    ----see VAR_0414372 C R mis40--------
    VAR_0414364
    ----see VAR_0414362 R H mis40--------
    VAR_0414404
    ----see VAR_0414402 P L mis40--------
    VAR_0414394
    ----see VAR_0414392 R C mis40--------
    VAR_0414344
    ----see VAR_0414342 A E mis40--------

    HapMap Linkage Disequilibrium report for INSRR (156809855 - 156828810 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for INSRR:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv831659CNV Loss17160897
    nsv831648CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing INSRR
    DNA2.0 Custom Variant and Variant Library Synthesis for INSRR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 147671    OMIM disorders: --

    9 diseases for INSRR:    About MalaCards
    neurofibrosarcoma    vesicoureteral reflux    neuroblastoma    prostate cancer
    prostatitis    adenocarcinoma    pancreatitis    neuronitis
    breast cancer

    1 disease from the University of Copenhagen DISEASES database for INSRR:
    Neurofibrosarcoma

    INSRR for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for INSRR gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 7 10535406 (3)

    Genetic Association Database (GAD): INSRR
    Human Genome Epidemiology (HuGE) Navigator: INSRR (3 documents)

    Export disorders for INSRR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for INSRR gene, integrated from 9 sources (see all 51):
    (articles sorted by number of sources associating them with INSRR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Primary structure of a putative receptor for a ligand of the insulin family. (PubMed id 2768234)1, 2, 3 Shier P. and Watt V.M. (1989)
    2. Localization of the insulin receptor-related receptor gene to human chromosome 1. (PubMed id 2249481)1, 3, 9 Shier P....Watt V.M. (1990)
    3. Cloning and sequencing of the complete cDNA encoding the human insulin receptor related receptor. (PubMed id 10226785)1, 2, 9 Haenze J.... Kiess W. (1999)
    4. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (2010)
    5. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)1, 4 Lu Y....Boer J.M. (2008)
    6. Correlation of type I insulin-like growth factor receptor (IGF-I-R) and insulin receptor-related receptor (IRR) messenger RNA levels in tumor cell lines from pediatric tumors of neuronal origin. (PubMed id 10535406)1, 9 Elmlinger M.W....Kiess W. (1999)
    7. Coexpression of insulin receptor-related receptor and insulin-like growth factor 1 receptor correlates with enhanced apoptosis and dedifferentiation in human neuroblastomas. (PubMed id 14654552)1, 9 Weber A....Christiansen H. (2003)
    8. Characterization of a hybrid receptor formed by dimerization of the insulin receptor-related receptor (IRR) with the insulin receptor (IR): coexpression of cDNAs encoding human IRR and human IR in NIH-3T3 cells. (PubMed id 8916919)1, 9 Jui H.Y....Taylor S.I. (1996)
    9. Characterization of the endogenous insulin receptor-related receptor in neuroblastomas. (PubMed id 7829525)1, 9 Kovacina K.S. and Roth R.A. (1995)
    10. The insulin receptor-related receptor. Tissue expression, ligand binding specificity, and signaling capabilities. (PubMed id 1326521)1, 9 Zhang B. and Roth R.A. (1992)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3645 HGNC: 6093 AceView: INSRR Ensembl:ENSG00000027644 euGenes: HUgn3645
    ECgene: INSRR Kegg: 3645 H-InvDB: INSRR

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for INSRR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for INSRR gene:
    Search GeneIP for patents involving INSRR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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