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INSM2 Gene

protein-coding   GIFtS: 46
GCID: GC14P036003

Insulinoma-Associated 2

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disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Insulinoma-Associated 21 2     IA-62
IA62 3 5     Insulinoma-Associated Protein 22
Zinc Finger Protein IA-62 3     Insulinoma-Associated Protein IA-62
Mlt 11     mlt12

External Ids:    HGNC: 175391   Entrez Gene: 846842   Ensembl: ENSG000001683487   OMIM: 6140275   UniProtKB: Q96T923   

Export aliases for INSM2 gene to outside databases

Previous GC identifers: GC14P033381 GC14P029790 GC14P033993 GC14P035072 GC14P016117


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for INSM2 Gene:
INSM2 (insulinoma-associated 2) is a protein-coding gene. An important paralog of this gene is INSM1.

UniProtKB/Swiss-Prot: INSM2_HUMAN, Q96T92
Function: May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the INSM2 gene promoter:
         E2F-4   E2F-3a   E2F-5   NRSF form 1   E2F-2   Tal-1beta   NRSF form 2   E2F   E2F-1   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidINSM2 promoter sequence
   Search Chromatin IP Primers for INSM2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat INSM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q13.2   Ensembl cytogenetic band:  14q13.2   HGNC cytogenetic band: 14q13.1

INSM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INSM2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P036003:  view genomic region     (about GC identifiers)

Start:
36,003,248 bp from pter      End:
36,006,260 bp from pter
Size:
3,013 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: INSM2_HUMAN, Q96T92 (See protein sequence)
Recommended Name: Insulinoma-associated protein 2  
Size: 566 amino acids; 59491 Da
Developmental stage: Expressed in the islet-like cells of the developing pancreas and epithelial cells of the
duodenum from gestational weeks 8 to 20 (at protein level)
Sequence caution: Sequence=AAK49393.1; Type=Frameshift; Positions=123, 127;
Secondary accessions: A1L432 Q8N8K7 Q96Q84

Explore the universe of human proteins at neXtProt for INSM2: NX_Q96T92

Explore proteomics data for INSM2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See INSM2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115983.3  
    ENSEMBL proteins: 
     ENSP00000306523  

    INSM2 Human Recombinant Protein Products:

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    Novus Biologicals INSM2 Protein
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for INSM2

     
    Search eBioscience for Proteins for INSM2 

     
    antibodies-online proteins for INSM2 (2 products) 

     
    antibodies-online peptides for INSM2

    INSM2 Antibody Products:

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    antibodies-online antibodies for INSM2 (13 products) 

    INSM2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for INSM2
    Cloud-Clone Corp. CLIAs for INSM2
    Search eBioscience for ELISAs for INSM2 
    antibodies-online kits for INSM2 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q96T92

    ProtoNet protein and cluster: Q96T92

    UniProtKB/Swiss-Prot: INSM2_HUMAN, Q96T92
    Similarity: Contains 5 C2H2-type zinc fingers


    Find genes that share domains with INSM2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: INSM2_HUMAN, Q96T92
    Function: May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons (By
    similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with INSM2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for INSM2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for INSM2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for INSM2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for INSM2

    miRNA
    Products:
        
    miRTarBase miRNAs that target INSM2:
    hsa-mir-335-5p (MIRT018669)

    Block miRNA regulation of human, mouse, rat INSM2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate INSM2 (see all 11):
    hsa-miR-600 hsa-miR-520d-5p hsa-miR-513a-5p hsa-miR-27a hsa-miR-876-3p hsa-miR-587 hsa-miR-3681 hsa-miR-524-5p
    SwitchGear 3'UTR luciferase reporter plasmidINSM2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for INSM2
    Predesigned siRNA for gene silencing in human, mouse, rat INSM2

    Gene Editing
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: INSM2 (NM_032594)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INSM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INSM2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for INSM2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INSM2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    INSM2_HUMAN, Q96T92: Cytoplasm (By similarity). Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with INSM2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for INSM2
    Interactions:

        Search GeneGlobe Interaction Network for INSM2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for INSM2 (Q96T923 ENSP000003065234) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZSCAN1Q8NBB43, ENSP000002823264I2D: score=1 STRING: ENSP00000282326
    FARP1ENSP000003229264STRING: ENSP00000322926
    FARP2ENSP000002640424STRING: ENSP00000264042
    FRMD7ENSP000002985424STRING: ENSP00000298542
    BTRCENSP000003592064STRING: ENSP00000359206
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    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with INSM2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for INSM2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for INSM2 gene: 
    NM_032594.3  

    Unigene Cluster for INSM2:

    Insulinoma-associated 2
    Hs.62813  [show with all ESTs]
    Unigene Representative Sequence: AF260323
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000307169(uc001wth.1)
    miRNA
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    Block miRNA regulation of human, mouse, rat INSM2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate INSM2 (see all 11):
    hsa-miR-600 hsa-miR-520d-5p hsa-miR-513a-5p hsa-miR-27a hsa-miR-876-3p hsa-miR-587 hsa-miR-3681 hsa-miR-524-5p
    SwitchGear 3'UTR luciferase reporter plasmidINSM2 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat INSM2
    Clone
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    OriGene clones in human, mouse for INSM2 (see all 6)
    OriGene ORF clones in mouse, rat for INSM2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: INSM2 (NM_032594)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INSM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INSM2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for INSM2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat INSM2
      QuantiTect SYBR Green Assays in human, mouse, rat INSM2
      QuantiFast Probe-based Assays in human, mouse, rat INSM2

    Additional mRNA sequence: 

    AB037912.1 AF260323.1 AK096639.1 BC130377.1 BC130379.1 JX403968.1 

    1 DOTS entry:

    DT.40114524 

    16 AceView cDNA sequences:

    NM_032594 BX394847 BX388388 AW090573 AW090356 AK096639 AB037912 AF260323 
    AU252443 BE312386 BX351134 BG519620 AU252442 AW149262 AW148539 BF312968 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    INSM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCATTCTTA
    INSM2 Expression
    About this image


    INSM2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Neurons
             Midbrain dopaminergic-like neurons
     
     Eye (Sensory Organs)
             Retina
     
     Neural Tube (Nervous System)
             Metencephalon
     
     Brain (Nervous System)
             Midbrain dopaminergic-like neurons
    INSM2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    INSM2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.62813

    UniProtKB/Swiss-Prot: INSM2_HUMAN, Q96T92
    Tissue specificity: Expressed in heart, liver, skeletal muscle, kidney and pancreas, and, to a lesser extent, in
    brain, lung and spleen. In the pancreas, expressed in islet cells, including insulin- and glucagon-producing
    alpha- and beta-cells, but not in acinar cells (at protein level). Detected in adrenal glands, particularly in
    the deeper layer of the cortex (at protein level)

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INSM2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for INSM2 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Insm21 , 5 insulinoma-associated 21, 5 76.4(n)1
    75.25(a)1
      12 (24.05 cM)5
    568561  NM_020287.21  NP_064683.21 
     555989175 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7928911 insulinoma-associated protein 2-like 54.16(n)
    54.51(a)
      792891  XM_001332478.5  XP_001332514.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta nerfin-16
    nerfin-26
    nervous fingers 2
    22(a)
    16(a)
    many ↔ many
    many ↔ many
    3L(909112-912319)
    3R(5896839-5899483)
    worm
    (Caenorhabditis elegans)
    Secernentea egl-466
    Protein EGL-46 (egl-46) mRNA, complete cds
    29(a)
    1 → many
    V(6679329-6681573) WBGene00001210


    ENSEMBL Gene Tree for INSM2 (if available)
    TreeFam Gene Tree for INSM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for INSM2 gene
    INSM12  

    Find genes that share paralogs with INSM2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for INSM2 (see all 114)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1818412411,2
    --36001365(+) GCTGAC/TATGTC 1 -- us2k10--------
    rs745528081,2
    C--36001412(+) CTGCTA/CAAGGA 1 -- us2k10--------
    rs1448763751,2
    C--36001418(+) AAGGAC/TTCAAA 1 -- us2k10--------
    rs1490426261,2
    --36001602(+) ACAAAA/GTACAA 1 -- us2k10--------
    rs19582591,2
    C,H--36001610(+) CAATAG/CAATGA 1 -- us2k19Minor allele frequency- C:0.01NA WA CSA 135
    rs1431756111,2
    C--36001619(+) GAAAAA/CTATGA 1 -- us2k10--------
    rs2017011851,2
    C--36001623(+) AATAT-/GAGAATG 1 -- us2k10--------
    rs1482856731,2
    C--36001685(+) CCCACA/GGTATT 1 -- us2k10--------
    rs1404131271,2
    --36001866(+) TACCCA/TTTATC 1 -- us2k10--------
    rs1454008651,2
    --36001875(+) TCTAAC/TTAAAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for INSM2 (36003248 - 36006260 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for INSM2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv29225CNV Loss19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing INSM2
    DNA2.0 Custom Variant and Variant Library Synthesis for INSM2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614027    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for INSM2:
    Diabetes mellitus

    Find genes that share disorders with INSM2           About GenesLikeMe


    Export disorders for INSM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for INSM2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with INSM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of insulinoma-associated 2 (INSM2) in pancreatic islet cells is regulated by the transcription factors Ngn3 and NeuroD1. (PubMed id 21343251)1, 2 Cai T....Notkins A.L. (Endocrinology 2011)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Predictive power of screening for antibodies against insulinoma-associated protein 2 beta (IA-2beta) and zinc transporter-8 to select first-degree relatives of type 1 diabetic patients with risk of rapid progression to clinical onset of the disease: implications for prevention trials. (PubMed id 20091020)1 De Grijse J....Gorus F.K. (Diabetologia 2010)
    4. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (Cell 2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)2 Heilig R.... Weissenbach J. (Nature 2003)
    7. Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma. (PubMed id 12880961)2 Ohira M.... Nakagawara A. (Cancer Lett. 2003)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84684 HGNC: 17539 AceView: INSM2 Ensembl:ENSG00000168348 euGenes: HUgn84684
    ECgene: INSM2 H-InvDB: INSM2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for INSM2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for INSM2 gene:
    Search GeneIP for patents involving INSM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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