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Aliases for INSM2 Gene

Aliases for INSM2 Gene

  • Insulinoma-Associated 2 2 3 5
  • Zinc Finger Protein IA-6 3 4
  • IA6 3 4
  • Insulinoma-Associated Protein IA-6 3
  • INSM2 Variant 1 3
  • Mlt 1 2
  • IA-6 3
  • Mlt1 3

External Ids for INSM2 Gene

Previous GeneCards Identifiers for INSM2 Gene

  • GC14P033381
  • GC14P029790
  • GC14P033993
  • GC14P035072
  • GC14P036003
  • GC14P016117

Summaries for INSM2 Gene

GeneCards Summary for INSM2 Gene

INSM2 (Insulinoma-Associated 2) is a Protein Coding gene. Diseases associated with INSM2 include Insulinoma. An important paralog of this gene is INSM1.

UniProtKB/Swiss-Prot for INSM2 Gene

  • May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INSM2 Gene

Genomics for INSM2 Gene

Regulatory Elements for INSM2 Gene

Enhancers for INSM2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around INSM2 on UCSC Golden Path with GeneCards custom track

Genomic Location for INSM2 Gene

35,534,042 bp from pter
35,537,054 bp from pter
3,013 bases
Plus strand

Genomic View for INSM2 Gene

Genes around INSM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INSM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INSM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INSM2 Gene

Proteins for INSM2 Gene

  • Protein details for INSM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Insulinoma-associated protein 2
    Protein Accession:
    Secondary Accessions:
    • A1L432
    • J9Y024
    • Q8N8K7
    • Q96Q84

    Protein attributes for INSM2 Gene

    566 amino acids
    Molecular mass:
    59491 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAK49393.1; Type=Frameshift; Positions=123, 127; Evidence={ECO:0000305};

neXtProt entry for INSM2 Gene

Proteomics data for INSM2 Gene at MOPED

Post-translational modifications for INSM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for INSM2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for INSM2
  • Santa Cruz Biotechnology (SCBT) Antibodies for INSM2

No data available for DME Specific Peptides for INSM2 Gene

Domains & Families for INSM2 Gene

Protein Domains for INSM2 Gene

Suggested Antigen Peptide Sequences for INSM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 5 C2H2-type zinc fingers.
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with INSM2: view

Function for INSM2 Gene

Molecular function for INSM2 Gene

UniProtKB/Swiss-Prot Function:
May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons.
genes like me logo Genes that share phenotypes with INSM2: view

Animal Model Products

miRNA for INSM2 Gene

miRTarBase miRNAs that target INSM2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for INSM2 Gene

Localization for INSM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for INSM2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Jensen Localization Image for INSM2 Gene COMPARTMENTS Subcellular localization image for INSM2 gene
Compartment Confidence
nucleus 5
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for INSM2 Gene

Pathways & Interactions for INSM2 Gene

SuperPathways for INSM2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for INSM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with INSM2: view

No data available for Pathways by source and SIGNOR curated interactions for INSM2 Gene

Drugs & Compounds for INSM2 Gene

No Compound Related Data Available

Transcripts for INSM2 Gene

mRNA/cDNA for INSM2 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for INSM2 Gene

Insulinoma-associated 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for INSM2 Gene

No ASD Table

Relevant External Links for INSM2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for INSM2 Gene

mRNA expression in normal human tissues for INSM2 Gene

mRNA differential expression in normal tissues according to GTEx for INSM2 Gene

This gene is overexpressed in Brain - Hypothalamus (x8.0), Brain - Frontal Cortex (BA9) (x6.8), Brain - Cortex (x5.5), Brain - Anterior cingulate cortex (BA24) (x5.2), Brain - Putamen (basal ganglia) (x5.1), and Brain - Nucleus accumbens (basal ganglia) (x4.5).

Protein differential expression in normal tissues from HIPED for INSM2 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for INSM2 Gene

SOURCE GeneReport for Unigene cluster for INSM2 Gene Hs.62813

mRNA Expression by UniProt/SwissProt for INSM2 Gene

Tissue specificity: Expressed in heart, liver, skeletal muscle, kidney and pancreas, and, to a lesser extent, in brain, lung and spleen. In the pancreas, expressed in islet cells, including insulin- and glucagon-producing alpha- and beta-cells, but not in acinar cells (at protein level). Detected in adrenal glands, particularly in the deeper layer of the cortex (at protein level).
genes like me logo Genes that share expression patterns with INSM2: view

Protein tissue co-expression partners for INSM2 Gene

- Elite partner

Primer Products

Orthologs for INSM2 Gene

This gene was present in the common ancestor of animals.

Orthologs for INSM2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia INSM2 35
  • 85.59 (n)
  • 85.9 (a)
(Canis familiaris)
Mammalia INSM2 35
  • 86.45 (n)
  • 85.97 (a)
INSM2 36
  • 85 (a)
(Mus musculus)
Mammalia Insm2 35
  • 76.4 (n)
  • 75.25 (a)
Insm2 16
Insm2 36
  • 73 (a)
(Pan troglodytes)
Mammalia INSM2 35
  • 99.53 (n)
  • 99.12 (a)
INSM2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Insm2 35
  • 76.36 (n)
  • 75 (a)
(Danio rerio)
Actinopterygii LOC792891 35
  • 54.16 (n)
  • 54.51 (a)
INSM2 36
  • 49 (a)
fruit fly
(Drosophila melanogaster)
Insecta nerfin-1 36
  • 22 (a)
nerfin-2 36
  • 16 (a)
(Caenorhabditis elegans)
Secernentea egl-46 36
  • 29 (a)
Species with no ortholog for INSM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for INSM2 Gene

Gene Tree for INSM2 (if available)
Gene Tree for INSM2 (if available)

Paralogs for INSM2 Gene

Paralogs for INSM2 Gene

genes like me logo Genes that share paralogs with INSM2: view

Variants for INSM2 Gene

Sequence variations from dbSNP and Humsavar for INSM2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1958260 - 35,534,869(+) CACGG(A/G)CTGCG reference, missense
rs1952391 -- 35,534,103(+) CGGGG(A/C)GGCCC utr-variant-5-prime
rs1952392 -- 35,534,163(+) AGCCG(C/T)GGCGA utr-variant-5-prime
rs3809445 -- 35,535,333(-) AGTCC(G/T)CTCTA reference, synonymous-codon
rs8012243 -- 35,533,509(+) AGATG(A/G)ACTCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for INSM2 Gene

Variant ID Type Subtype PubMed ID
esv29225 CNV Loss 19812545

Variation tolerance for INSM2 Gene

Residual Variation Intolerance Score: 60.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.59; 44.87% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for INSM2 Gene

Disorders for INSM2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for INSM2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
  • islet cell tumor
- elite association - COSMIC cancer census association via MalaCards
Search INSM2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for INSM2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with INSM2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for INSM2 Gene

Publications for INSM2 Gene

  1. Expression of insulinoma-associated 2 (INSM2) in pancreatic islet cells is regulated by the transcription factors Ngn3 and NeuroD1. (PMID: 21343251) Cai T. … Notkins A.L. (Endocrinology 2011) 3 4 67
  2. Predictive power of screening for antibodies against insulinoma-associated protein 2 beta (IA-2beta) and zinc transporter-8 to select first-degree relatives of type 1 diabetic patients with risk of rapid progression to clinical onset of the disease: implications for prevention trials. (PMID: 20091020) De Grijse J. … Gorus F.K. (Diabetologia 2010) 3
  3. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T. … Hayashizaki Y. (Cell 2010) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for INSM2 Gene

Sources for INSM2 Gene