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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

INSM1 Gene

protein-coding   GIFtS: 54
GCID: GC20P020348

Insulinoma-Associated 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Insulinoma-Associated 11 2
IA12 3 5
Zinc Finger Protein IA-12 3
IA-12
Insulinoma-Associated Protein 12

External Ids:    HGNC: 60901   Entrez Gene: 36422   Ensembl: ENSG000001734047   OMIM: 6000105   UniProtKB: Q011013   

Export aliases for INSM1 gene to outside databases

Previous GC identifers: GC20P020336 GC20P020343 GC20P020296


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for INSM1 Gene:
Insulinoma-associated 1 (INSM1) gene is intronless and encodes a protein containing both a zinc finger DNA-binding
domain and a putative prohormone domain. This gene is a sensitive marker for neuroendocrine differentiation of
human lung tumors. (provided by RefSeq, Jul 2008)

GeneCards Summary for INSM1 Gene: 
INSM1 (insulinoma-associated 1) is a protein-coding gene. Diseases associated with INSM1 include cervix uteri carcinoma in situ, and insulinoma, and among its related super-pathways are Axon guidance and Maturity onset diabetes of the young. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is INSM2.

UniProtKB/Swiss-Prot: INSM1_HUMAN, Q01101
Function: May be associated with the transformation of neuroendocrine cells

Gene Wiki entry for INSM1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.2  NT_011387.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the INSM1 gene promoter:
         MEF-2A   Sp1   aMEF-2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidINSM1 promoter sequence
   Search SABiosciences Chromatin IP Primers for INSM1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INSM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p11.2   Ensembl cytogenetic band:  20p11.23   HGNC cytogenetic band: 20p11.2

INSM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INSM1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P020348:  view genomic region     (about GC identifiers)

Start:
20,348,765 bp from pter      End:
20,351,593 bp from pter
Size:
2,829 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: INSM1_HUMAN, Q01101 (See protein sequence)
Recommended Name: Insulinoma-associated protein 1  
Size: 510 amino acids; 52923 Da
Subcellular location: Nucleus (Potential)
2 PDB 3D structures from and Proteopedia for INSM1:
2LV2 (3D)        3ZMS (3D)    

Explore the universe of human proteins at neXtProt for INSM1: NX_Q01101

Explore proteomics data for INSM1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q01101

  • INSM1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    INSM1 Protein Expression
    REFSEQ proteins: NP_002187.1  
    ENSEMBL proteins: 
     ENSP00000312631  
    Reactome Protein details: Q01101
    Human Recombinant Protein Products for INSM1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for INSM1
    OriGene Protein Over-expression Lysate for INSM1
    OriGene MassSpec for INSM1 
    OriGene Custom Protein Services for INSM1
    GenScript Custom Purified and Recombinant Proteins Services for INSM1
    Novus Biologicals INSM1 Protein
    Novus Biologicals INSM1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for INSM1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--

    INSM1 for ontologies           About GeneDecksing



    INSM1 Antibody Products: 
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    Cloud-Clone Corp. Antibodies for INSM1 
    ThermoFisher Antibodies for INSM1
    LSBio Antibodies in human, mouse, rat for INSM1 

    Assay Products for INSM1: 
    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for INSM1 
    Cloud-Clone Corp. CLIAs for INSM1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q01101

    ProtoNet protein and cluster: Q01101

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: INSM1_HUMAN, Q01101
    Similarity: Contains 5 C2H2-type zinc fingers


    INSM1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: INSM1_HUMAN, Q01101
    Function: May be associated with the transformation of neuroendocrine cells

         Genatlas biochemistry entry for INSM1:
    insulinoma and other neuroendocrine tumor cell lines,intron less gene

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    INSM1 for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Insm1):
     cellular  craniofacial  digestive/alimentary  endocrine/exocrine gland  homeostasis/metabolism 
     mortality/aging  nervous system  no phenotypic analysis  respiratory system  taste/olfaction 

    INSM1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for INSM1: Insm1tm1.1Jga Insm1tm1Jga

       inGenious Targeting Laboratory - Custom generated mouse model solutions for INSM1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for INSM1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for INSM1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for INSM1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat INSM1
    8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate INSM1 (see all 38):
    hsa-miR-548j hsa-miR-128 hsa-miR-3653 hsa-miR-3658 hsa-miR-889 hsa-miR-186 hsa-miR-548d-5p hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidINSM1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for INSM1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat INSM1

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of INSM1

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for INSM1 (see all 5)
    OriGene ORF clones in mouse, rat for INSM1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: INSM1 (NM_002196)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INSM1
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat INSM1
    Sirion Biotech Customized lentivirus for stable overexpression of INSM1 
                         Customized lentivirus expression plasmids for stable overexpression of INSM1 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for INSM1
    Search LifeMap BioReagents cell lines for INSM1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INSM1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for INSM1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Axon guidance
    Developmental Biology0.69
    2Regulation of beta-cell development
    Regulation of beta-cell development0.56
    3Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells
    Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3        Reactome Pathways for INSM1
        Developmental Biology
    Regulation of beta-cell development
    Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells



    INSM1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for INSM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/12 Interacting proteins for INSM1 (Q011012, 3 ENSP000003126314) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MPP3Q133682, 3MINT-64787 I2D: score=4 
    SORBS1Q9BX663, ENSP000003551364I2D: score=2 STRING: ENSP00000360272 STRING: ENSP00000355136
    ENSG00000258947Q135093I2D: score=2 
    TUBB3Q135093I2D: score=2 
    HDAC3O153793, ENSP000003029674I2D: score=1 STRING: ENSP00000302967
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003323type B pancreatic cell development IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0030154cell differentiation ----
    GO:0031018endocrine pancreas development TAS--

    INSM1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    INSM1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for INSM1

    1 Novoseek inferred chemical compound relationship for INSM1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 34.9 4 12890672 (2), 8364910 (1)

    Search CenterWatch for drugs/clinical trials and news about INSM1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for INSM1 gene: 
    NM_002196.2  

    Unigene Cluster for INSM1:

    Insulinoma-associated 1
    Hs.89584  [show with all ESTs]
    Unigene Representative Sequence: NM_002196
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000310227(uc002wrx.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat INSM1
    8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate INSM1 (see all 38):
    hsa-miR-548j hsa-miR-128 hsa-miR-3653 hsa-miR-3658 hsa-miR-889 hsa-miR-186 hsa-miR-548d-5p hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidINSM1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for INSM1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat INSM1
    Clone
    Products:
         
    OriGene clones in human, mouse for INSM1 (see all 5)
    OriGene ORF clones in mouse, rat for INSM1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: INSM1 (NM_002196)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INSM1
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat INSM1
    Sirion Biotech Customized lentivirus for stable overexpression of INSM1 
                         Customized lentivirus expression plasmids for stable overexpression of INSM1 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for INSM1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INSM1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INSM1

    Additional mRNA sequence: M93119.1 

    1 DOTS entry:

    DT.311010 

    24/77 AceView cDNA sequences (see all 77):

    R39604 CA773550 BQ129933 CK819629 BU787491 AI797055 AI738960 AI634481 
    BE502873 BM129674 CB068045 AI298358 M93119 NM_002196 F10984 BU739149 
    BM717336 BM509966 BI964258 AI299451 BQ786762 F12813 CA775535 BI468405 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    INSM1 expression in normal human tissues (normalized intensities)      INSM1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCTAGAAAT
    INSM1 Expression
    About this image


    INSM1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 22 entries
             Endocrine Progenitor Cells Ventral Pancreatic Bud
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
     
     Brain (Nervous System)    fully expand to see all 17 entries
             Epithalamus
             Fetal Neuronal Stem Cells (NSC)   
             superior temporal gyrus   
     
     Neural Tube (Nervous System)    fully expand to see all 9 entries
             Telencephalon
             brain/forebrain/diencephalon   
     
     Nose (Sensory Organs)    fully expand to see all 5 entries
             sensory organ/nose   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 3 entries
             Muscle Progenitor Cells Mandibular Arch Muscles

    See INSM1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for INSM1

    SOURCE GeneReport for Unigene cluster: Hs.89584

    UniProtKB/Swiss-Prot: INSM1_HUMAN, Q01101
    Tissue specificity: Several tumor cell lines of neuroendocrine origin including pheochromocytoma, medullary
    thyroid carcinoma, insulinoma, pituitary tumor, and small cell lung carcinoma. Not found in any of the normal
    tissues tested

        SABiosciences Custom PCR Arrays for INSM1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INSM1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for INSM1 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Insm11 , 5 insulinoma-associated 11, 5 90.42(n)1
    93.31(a)1
      2 (71.33 cM)5
    536261  NM_016889.31  NP_058585.21 
     1462219215 
    lizard
    (Anolis carolinensis)
    Reptilia INSM16
    Uncharacterized protein
    54(a)
    1 ↔ 1
    4(80682945-80684096)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.147332 Xenopus laevis transcribed sequence with weak similarity to protein pirA42750 (H.sapiens) A42750 insulinoma-associated protein IA-1 - human less 81.7(n)    BG552346.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc13a092 wufc13a09 79.85(n)   323882  BC053119.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta nerfin-23   -- 37(a)   85F9   --
    worm
    (Caenorhabditis elegans)
    Secernentea egl-466
    Protein EGL-46
    26(a)
    1 → many
    V(6679329-6681575)


    ENSEMBL Gene Tree for INSM1 (if available)
    TreeFam Gene Tree for INSM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for INSM1 gene
    INSM22  

    INSM1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/76 SNPs in INSM1 are shown (see all 76)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs791262811,2
    C,F--20347054(+) TAAGCG/ATAAGT 1 -- us2k11Minor allele frequency- A:0.10WA 118
    rs1382596111,2
    C--20347329(+) GCGGA-/GGTGGG
            
    GGTGG
    1 -- us2k10--------
    rs1492037731,2
    C--20347441(+) GATTG-/CCCCCC 1 -- us2k10--------
    rs1435992391,2
    C--20347799(+) TGGGTA/CGGGCC 1 -- us2k10--------
    rs1166382301,2
    F--20348152(+) TTGTTT/GATTTC 1 -- us2k11Minor allele frequency- G:0.06WA 118
    rs1381462651,2
    --20348210(+) ACCGCC/TCCGGC 1 -- us2k10--------
    rs1931617001,2
    --20348241(+) TCAGCA/GCGCAC 1 -- us2k10--------
    rs81172591,2
    C,F,H--20348253(+) ACTTCC/TCCCTC 1 -- us2k1 trp317Minor allele frequency- T:0.14NS EA NA WA 2340
    rs1146843471,2
    F--20348335(+) GCGACC/TCGCGG 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs349174211,2
    C,F--20348536(+) GCGACG/CAGGGG 1 -- us2k11Minor allele frequency- C:0.00NA 2

    HapMap Linkage Disequilibrium report for INSM1 (20348765 - 20351593 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for INSM1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2666074CNV Deletion23128226

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing INSM1
    DNA2.0 Custom Variant and Variant Library Synthesis for INSM1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600010    OMIM disorders: --

    10 diseases for INSM1:    About MalaCards
    cervix uteri carcinoma in situ    insulinoma    neuroendocrine tumor    pituitary tumors
    lung cancer    herpes simplex    pheochromocytoma    thyroiditis
    pancreatitis    neuronitis


    INSM1 for disorders           About GeneDecksing

    6 Novoseek inferred disease relationships for INSM1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    insulinoma 72.1 7 1634555 (2), 11854618 (2), 11842116 (1), 8188699 (1)
    pituitary tumors 58.5 1 9245732 (1)
    neuroendocrine tumors 57.6 2 8188699 (1), 9245732 (1)
    lung tumor 49.3 2 8188699 (1), 8364910 (1)
    small cell lung cancer 44.9 1 8364910 (1)
    tumors 20.5 6 11842116 (1), 8188699 (1), 9245732 (1), 8364910 (1) (see all 5)


    Export disorders for INSM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for INSM1 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with INSM1)
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    1. Genomic organization, 5'-upstream sequence, and chromosomal localization of an insulinoma-associated intronless gene, IA-1. (PubMed id 8188699)1, 2, 3, 9 Lan M.S.... Notkins A.L. (1994)
    2. INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases. (PubMed id 16569215)1, 3, 9 Liu W.D....Lan M.S. (2006)
    3. A novel human insulinoma-associated cDNA, IA-1, encodes a protein with 'zinc-finger' DNA-binding motifs. (PubMed id 1634555)1, 2, 9 Goto Y....Lan M.S. (1992)
    4. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    5. Neuroendocrine differentiation factor, IA-1, is a transcriptional repressor and contains a specific DNA-binding domain: identification of consensus IA-1 binding sequence. (PubMed id 11842116)1, 9 Breslin M.B....Lan M.S. (2002)
    6. Expression of a novel zinc-finger cDNA, IA-1, is associated with rat AR42J cells differentiation into insulin-positive cells. (PubMed id 11854618)1, 9 Zhu M....Lan M.S. (2002)
    7. NeuroD1/E47 regulates the E-box element of a novel zinc finger transcription factor, IA-1, in developing nervous system. (PubMed id 12890672)1, 9 Breslin M.B....Lan M.S. (2003)
    8. Molecular characterization of the promoter region of a neuroendocrine tumor marker, IA-1. (PubMed id 9245732)1, 9 Li Q....Lan M.S. (1997)
    9. Functional role of an islet transcription factor, INSM 1/IA-1, on pancreatic acinar cell trans-differentiation. (PubMed id 21830214)1 Zhang T....Lan M.S. (2012)
    10. Herpes simplex virus induces the marked up-regulation of the zinc finger transcriptional factor INSM1, which modulates the expressio n and localization of the immediate early protein ICP0. (PubMed id 21609490)1 Kamakura M....Nishiyama Y. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3642 HGNC: 6090 AceView: INSM1 Ensembl:ENSG00000173404 euGenes: HUgn3642
    ECgene: INSM1 H-InvDB: INSM1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for INSM1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for INSM1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for INSM1 gene:
    Search GeneIP for patents involving INSM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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