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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

INSM1 Gene

protein-coding   GIFtS: 54
GCID: GC20P020348

insulinoma-associated 1
 Explore 13 diseases affiliated with
INSM1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for INSM1    

Aliases
for INSM1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Insulinoma-Associated 11 2
IA11 2 3 5
IA-11 2
Zinc Finger Protein IA-12 3
Insulinoma-Associated Protein 12

External Ids:    HGNC: 60901   Entrez Gene: 36422   Ensembl: ENSG000001734047   OMIM: 6000105   UniProtKB: Q011013   

Export aliases for INSM1 gene to outside databases

Previous GC identifers: GC20P020336 GC20P020343 GC20P020296


Summaries
for INSM1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for INSM1:
Insulinoma-associated 1 (INSM1) gene is intronless and encodes a protein containing both a zinc finger DNA-binding
domain and a putative prohormone domain. This gene is a sensitive marker for neuroendocrine differentiation of human
lung tumors. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: INSM1_HUMAN, Q01101
Function: May be associated with the transformation of neuroendocrine cells

Gene Wiki entry for INSM1


Genomic Views
for INSM1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011387.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the INSM1 gene promoter:
         MEF-2A   Sp1   aMEF-2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: INSM1 promoter sequence
   Search SABiosciences Chromatin IP Primers for INSM1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INSM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p11.2   Ensembl cytogenetic band:  20p11.23   HGNC cytogenetic band: 20p11.2

INSM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INSM1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P020348:  view genomic region     (about GC identifiers)

Start:
 20,348,765 bp from pter      End:
 20,351,593 bp from pter
Size:
 2,829 bases      Orientation:
 plus strand

Proteins
for INSM1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: INSM1_HUMAN, Q01101 (See protein sequence)
Recommended Name: Insulinoma-associated protein 1  
Size: 510 amino acids; 52923 Da
Subcellular location: Nucleus (Potential)
1 PDB 3D structure from and Proteopedia for INSM1:
2LV2 (3D)    

Explore the universe of human proteins at neXtProt for INSM1: NX_Q01101

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q01101

    • INSM1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002187.1  
    ENSEMBL proteins: 
     ENSP00000312631  
    Reactome Protein details: Q01101
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate: INSM1
    OriGene Custom Protein Services for INSM1 
    GenScript Custom Purified and Recombinant Proteins Services for INSM1
    Novus Biologicals INSM1 Protein
    Novus Biologicals INSM1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for INSM1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--


    INSM1 for ontologies           About GeneDecksing



    INSM1 Antibody Products: 
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    OriGene Antibodies: INSM1
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    Novus Biologicals INSM1 Antibody
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    Uscn Antibodies for INSM1
    ThermoFisher Antibodies for INSM1

    Assay Products for INSM1: 
    Browse Kits and Assays available from EMD Millipore
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    Uscn ELISAs and CLIAs for INSM1

    Protein Domains /
    Families
    for INSM1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    INSM1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q01101

    ProtoNet protein and cluster: Q01101

    1 Blocks protein family: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: INSM1_HUMAN, Q01101
    Similarity: Contains 5 C2H2-type zinc fingers


    Function
    for INSM1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: INSM1_HUMAN, Q01101
    Function: May be associated with the transformation of neuroendocrine cells

         Genatlas biochemistry entry for INSM1:
    insulinoma and other neuroendocrine tumor cell lines,intron less gene

    miRNA
    Products:            		 OriGene 3'-UTR Clone: INSM1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat INSM1
    8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate INSM1 (see all 38):
    hsa-miR-548j hsa-miR-128 hsa-miR-3653 hsa-miR-3658 hsa-miR-889 hsa-miR-186 hsa-miR-548d-5p hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmid: INSM1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for INSM1 (see all 4)
    OriGene shRNA RFP: INSM1
    OriGene siRNA: INSM1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat INSM1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for INSM1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for INSM1 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for INSM1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: INSM1 (NM_002196)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INSM1
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat INSM1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for INSM1
    Search LifeMap BioReagents cell lines for INSM1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INSM1

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding IEA--


    INSM1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for INSM1: Insm1tm1.1Jga Insm1tm1Jga
         10 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Insm1):
     cellular  craniofacial  digestive/alimentary  endocrine/exocrine gland  homeostasis/metabolism 
     mortality/aging  nervous system  no phenotypic analysis  respiratory system  taste/olfaction 

    INSM1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for INSM1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1NEUROG3-dependent synthesis of INSM1
    		NEUROG3-dependent synthesis of INSM11.00
    2Regulation of beta-cell development
    		Regulation of beta-cell development1.00
    3Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells
    		Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells1.00
    4Axon guidance
    		Developmental Biology0.69

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4        Reactome Pathways for INSM1
        Developmental Biology
    Regulation of beta-cell development
    NEUROG3-dependent synthesis of INSM1
    Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells



    INSM1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for INSM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/13 Interacting proteins for INSM1 (Q011012, 3 ENSP000003126314) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MPP3Q133682, 3MINT-64787 I2D: score=4 
    ENSG00000258947Q135093I2D: score=2 
    TUBB3Q135093I2D: score=2 
    HDAC3O153793, ENSP000003029674I2D: score=1 STRING: ENSP00000302967
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003323type B pancreatic cell development IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0030154cell differentiation ----
    GO:0031018endocrine pancreas development TAS--


    INSM1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for INSM1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    INSM1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for INSM1
    1 Novoseek chemical compound relationship for INSM1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 34.9 4 12890672 (2), 8364910 (1)

    Search CenterWatch for drugs/clinical trials and news about INSM1 

    Transcripts
    for INSM1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for INSM1 gene: 
    NM_002196.2  

    Unigene Cluster for INSM1:

    Insulinoma-associated 1
    Hs.89584  [show with all ESTs]
    Unigene Representative Sequence: NM_002196
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000310227(uc002wrx.3)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: INSM1
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat INSM1
    8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate INSM1 (see all 38):
    hsa-miR-548j hsa-miR-128 hsa-miR-3653 hsa-miR-3658 hsa-miR-889 hsa-miR-186 hsa-miR-548d-5p hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmid: INSM1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for INSM1 (see all 4)
    OriGene shRNA RFP: INSM1
    OriGene siRNA: INSM1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat INSM1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for INSM1 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for INSM1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: INSM1 (NM_002196)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INSM1
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat INSM1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for INSM1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat INSM1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INSM1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INSM1

    Additional cDNA sequence: M93119.1 

    1 DOTS entry:

    DT.311010 

    24/77 AceView cDNA sequences (see all 77):

    F10984 R39604 AI738960 BE502873 BU739149 CB068045 AI797055 CA773550 
    BU787491 BM129674 M93119 BQ129933 NM_002196 AI634481 CK819629 AI298358 
    BM717336 BE551212 AI459295 BM509966 BE791729 BM504775 AI299451 F13396 

    GeneLoc Exon Structure


    Expression
    for INSM1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    INSM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTCTAGAAAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    INSM1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/26 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 26) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    PancreasDorsal Pancreatic BudAlpha Progenitor CellsPancreas
    PancreasDorsal Pancreatic BudBeta/Delta Progenitor CellsPancreas
    PancreasDorsal Pancreatic BudEarly Beta Progenitor CellsPancreas
    PancreasDorsal Pancreatic BudEndocrine Progenitor CellsPancreas
    PancreasDorsal Pancreatic BudImmature Beta Progenitor CellsPancreas
    PancreasDorsal Pancreatic BudIntermediate Beta Progenitor CellsPancreas
    PancreasDorsal Pancreatic BudPancreatic Progenitor CellsPancreas
    PancreasIslets of LangerhansAlpha CellsPancreas
    PancreasIslets of LangerhansDelta CellsPancreas
    PancreasIslets of LangerhansMature Beta CellsPancreas
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)
    Posterior foregut-like cells (A scalable, suspensi...)
    Epiblast-like cells (Reconstitution of mo...)

    See INSM1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for INSM1

    SOURCE GeneReport for Unigene cluster: Hs.89584

    UniProtKB/Swiss-Prot: INSM1_HUMAN, Q01101
    Tissue specificity: Several tumor cell lines of neuroendocrine origin including pheochromocytoma, medullary thyroid
    carcinoma, insulinoma, pituitary tumor, and small cell lung carcinoma. Not found in any of the normal tissues tested

        SABiosciences Custom PCR Arrays for INSM1
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INSM1

    Orthologs
    for INSM1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for INSM1 gene from 6/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Insm11 , 5 insulinoma-associated 11, 5 90.42(n)1
    93.31(a)1    		   2 (71.33 cM)5
    536261  NM_016889.31  NP_058585.21 
     1462219215 
    lizard
    (Anolis carolinensis)    		 Reptilia INSM16
    		 --
    		 58(a)
    		 1 ↔ 1
    		 4(80682945-80684096)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.147332 Xenopus laevis transcribed sequence with weak similarity more 81.7(n)    BG552346.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufc13a092 wufc13a09 79.85(n)   323882  BC053119.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta nerfin-23   -- 37(a)   85F9   --
    worm
    (Caenorhabditis elegans)    		 Secernentea egl-466
    		 EGg Laying defective family member (egl-46)
    		 31(a)
    		 1 → many
    		 V(6679312-6681558)


    ENSEMBL Gene Tree for INSM1 (if available)
    TreeFam Gene Tree for INSM1 (if available) 

    Paralogs
    for INSM1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for INSM1 gene
    INSM22  

    INSM1 for paralogs           About GeneDecksing



    Genomic Variants
    for INSM1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/56 NCBI SNPs in INSM1 are shown (see all 56)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 20 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs791262811,2
    		C,F,--20347054(+) TAAGCG/ATAAGT 1 -- us2k11Minor allele frequency- A:0.10WA 118
    rs1382596111,2
    		--20347329(+) GCGGA-/GGTGGG
                GGTGG     		1 -- us2k10--------
    rs1492037731,2
    		--20347441(+) GATTG-/CCCCCC 1 -- us2k10--------
    rs1435992391,2
    		--20347799(+) TGGGTA/CGGGCC 1 -- us2k10--------
    rs1166382301,2
    		F,--20348152(+) TTGTTT/GATTTC 1 -- us2k11Minor allele frequency- G:0.06WA 118
    rs1381462651,2
    		--20348210(+) ACCGCC/TCCGGC 1 -- us2k10--------
    rs1931617001,2
    		--20348241(+) TCAGCA/GCGCAC 1 -- us2k10--------
    rs81172591,2
    		C,F,H,--20348253(+) ACTTCC/TCCCTC 1 -- us2k1 trp317Minor allele frequency- T:0.14NS EA NA WA 2340
    rs1146843471,2
    		F,--20348335(+) GCGACC/TCGCGG 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs349174211,2
    		--20348536(+) GCGACG/CAGGGG 1 -- us2k11Minor allele frequency- C:0.00NA 2

    HapMap Linkage Disequilibrium report for INSM1 (20348765 - 20351593 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for INSM1: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing INSM1
    DNA2.0 Custom Variant and Variant Library Synthesis for INSM1

    Disorders / Diseases
    for INSM1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    INSM1 for disorders           About GeneDecksing

    OMIM gene information: 600010    OMIM disorders: --

    13 diseases for INSM1:    About MalaCards
    insulinoma    cervix uteri carcinoma in situ    neuroendocrine tumor    pituitary tumor
    herpes simplex    lung cancer    pheochromocytoma    thyroid carcinoma
    lung carcinoma    thyroiditis    carcinoma    pancreatitis
    neuronitis

    6 Novoseek disease relationships for INSM1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    insulinoma 72.1 7 1634555 (2), 11854618 (2), 11842116 (1), 8188699 (1)
    pituitary tumors 58.5 1 9245732 (1)
    neuroendocrine tumors 57.6 2 8188699 (1), 9245732 (1)
    lung tumor 49.3 2 8188699 (1), 8364910 (1)
    small cell lung cancer 44.9 1 8364910 (1)
    tumors 20.5 6 11842116 (1), 8188699 (1), 9245732 (1), 8364910 (1) (see all 5)


    Export disorders for INSM1 gene to outside databases

    Publications
    for INSM1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for INSM1 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with INSM1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization, 5'-upstream sequence, and chromosomal localization of an insulinoma-associated intronless gene, IA-1. (PubMed id 8188699)1, 2, 3, 9 Lan M.S.... Notkins A.L. (1994)
    2. INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases. (PubMed id 16569215)1, 3, 9 Liu W.D....Lan M.S. (2006)
    3. A novel human insulinoma-associated cDNA, IA-1, encodes a protein with 'zinc-finger' DNA-binding motifs. (PubMed id 1634555)1, 2, 9 Goto Y....Lan M.S. (1992)
    4. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    5. Neuroendocrine differentiation factor, IA-1, is a transcriptional repressor and contains a specific DNA-binding domain: identification of consensus IA-1 binding sequence. (PubMed id 11842116)1, 9 Breslin M.B....Lan M.S. (2002)
    6. Expression of a novel zinc-finger cDNA, IA-1, is associated with rat AR42J cells differentiation into insulin-positive cells. (PubMed id 11854618)1, 9 Zhu M....Lan M.S. (2002)
    7. NeuroD1/E47 regulates the E-box element of a novel zinc finger transcription factor, IA-1, in developing nervous system. (PubMed id 12890672)1, 9 Breslin M.B....Lan M.S. (2003)
    8. Molecular characterization of the promoter region of a neuroendocrine tumor marker, IA-1. (PubMed id 9245732)1, 9 Li Q....Lan M.S. (1997)
    9. Functional role of an islet transcription factor, INSM 1/IA-1, on pancreatic acinar cell trans-differentiation. (PubMed id 21830214)1 Zhang T....Lan M.S. (2012)
    10. Herpes simplex virus induces the marked up-regulation of the zinc finger transcriptional factor INSM1, which modulates the expressio n and localization of the immediate early protein ICP0. (PubMed id 21609490)1 Kamakura M....Nishiyama Y. (2011)

    External Searches for INSM1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing INSM1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3642 HGNC: 6090 AceView: INSM1 Ensembl:ENSG00000173404 euGenes: HUgn3642
    ECgene: INSM1 H-InvDB: INSM1

    Other Databases showing INSM1 gene

    (According to HUGE)
    About This Section
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    Specialized Databases showing INSM1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for INSM1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for INSM1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for INSM1 gene

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    IP news from LifeMap Sciences, Inc.)
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    		Patent Information for INSM1 gene:
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