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Aliases for INSL6 Gene

Aliases for INSL6 Gene

  • Insulin-Like 6 2 3
  • Relaxin/Insulin-Like Factor 1 2 3 4
  • Insulin-Like Peptide 6 3 4
  • RIF1 3 4
  • Insulin-Like Peptide INSL6 3
  • Insulin-Like Peptide 5 3

External Ids for INSL6 Gene

Previous GeneCards Identifiers for INSL6 Gene

  • GC09M005317
  • GC09M005145
  • GC09M005153
  • GC09M005119
  • GC09M005163

Summaries for INSL6 Gene

Entrez Gene Summary for INSL6 Gene

  • The protein encoded by this gene contains a classical signature of the insulin superfamily and is significantly similar to relaxin and relaxin-like factor. This gene is preferentially expressed in testis. Its expression in testis is restricted to interstitial cells surrounding seminiferous tubules, which suggests a role in sperm development and fertilization. [provided by RefSeq, Jul 2008]

GeneCards Summary for INSL6 Gene

INSL6 (Insulin-Like 6) is a Protein Coding gene. Among its related pathways are Transcriptional Regulatory Network in Embryonic Stem Cell. GO annotations related to this gene include hormone activity.

UniProtKB/Swiss-Prot for INSL6 Gene

  • May have a role in sperm development and fertilization

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INSL6 Gene

Genomics for INSL6 Gene

Regulatory Elements for INSL6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for INSL6 Gene

Start:
5,131,979 bp from pter
End:
5,185,668 bp from pter
Size:
53,690 bases
Orientation:
Minus strand

Genomic View for INSL6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for INSL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INSL6 Gene

Proteins for INSL6 Gene

  • Protein details for INSL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y581-INSL6_HUMAN
    Recommended name:
    Insulin-like peptide INSL6
    Protein Accession:
    Q9Y581
    Secondary Accessions:
    • A0AVS0
    • Q9NS16

    Protein attributes for INSL6 Gene

    Size:
    213 amino acids
    Molecular mass:
    24860 Da
    Quaternary structure:
    No Data Available

neXtProt entry for INSL6 Gene

Proteomics data for INSL6 Gene at MOPED

Post-translational modifications for INSL6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for INSL6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for INSL6 Gene

Domains for INSL6 Gene

Protein Domains for INSL6 Gene

Suggested Antigen Peptide Sequences for INSL6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y581

UniProtKB/Swiss-Prot:

INSL6_HUMAN :
  • Q9Y581
Family:
  • Belongs to the insulin family.
genes like me logo Genes that share domains with INSL6: view

No data available for Gene Families for INSL6 Gene

Function for INSL6 Gene

Molecular function for INSL6 Gene

GENATLAS Biochemistry: insulin-like 6,expressed in the testis
UniProtKB/Swiss-Prot Function: May have a role in sperm development and fertilization

Gene Ontology (GO) - Molecular Function for INSL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity NAS 10598589
genes like me logo Genes that share ontologies with INSL6: view

Phenotypes for INSL6 Gene

genes like me logo Genes that share phenotypes with INSL6: view

Animal Models for INSL6 Gene

MGI Knock Outs for INSL6:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for INSL6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for INSL6 Gene

Localization for INSL6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for INSL6 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for INSL6 Gene COMPARTMENTS Subcellular localization image for INSL6 gene
Compartment Confidence
extracellular 3
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for INSL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with INSL6: view

Pathways for INSL6 Gene

genes like me logo Genes that share pathways with INSL6: view

Pathways by source for INSL6 Gene

Interacting Proteins for INSL6 Gene

Gene Ontology (GO) - Biological Process for INSL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis --
GO:0007286 spermatid development IEA --
GO:0008150 biological_process ND --
GO:0008584 male gonad development IEA --
GO:0009566 fertilization IEA --
genes like me logo Genes that share ontologies with INSL6: view

Transcripts for INSL6 Gene

mRNA/cDNA for INSL6 Gene

(4) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(3) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for INSL6 Gene

Insulin-like 6:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for INSL6

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for INSL6 Gene

No ASD Table

Relevant External Links for INSL6 Gene

GeneLoc Exon Structure for
INSL6
ECgene alternative splicing isoforms for
INSL6

Expression for INSL6 Gene

mRNA expression in normal human tissues for INSL6 Gene

mRNA differential expression in normal tissues according to GTEx for INSL6 Gene

This gene is overexpressed in Testis (47.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for INSL6 Gene

SOURCE GeneReport for Unigene cluster for INSL6 Gene Hs.632648

mRNA Expression by UniProt/SwissProt for INSL6 Gene

Q9Y581-INSL6_HUMAN
Tissue specificity: Testis specific
genes like me logo Genes that share expressions with INSL6: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for INSL6 Gene

Orthologs for INSL6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for INSL6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INSL6 35
  • 99.06 (n)
  • 97.65 (a)
INSL6 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia INSL6 35
  • 79.23 (n)
  • 66.12 (a)
INSL6 36
  • 62 (a)
OneToOne
dog
(Canis familiaris)
Mammalia INSL6 35
  • 80.16 (n)
  • 67.14 (a)
INSL6 36
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Insl6 35
  • 67.64 (n)
  • 47.95 (a)
Insl6 16
Insl6 36
  • 46 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Insl6 35
  • 65.1 (n)
  • 48.24 (a)
Species with no ortholog for INSL6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for INSL6 Gene

ENSEMBL:
Gene Tree for INSL6 (if available)
TreeFam:
Gene Tree for INSL6 (if available)

Paralogs for INSL6 Gene

No data available for Paralogs for INSL6 Gene

Variants for INSL6 Gene

Sequence variations from dbSNP and Humsavar for INSL6 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1328919 -- 5,166,548(+) GCTTA(C/T)ACATT intron-variant
rs1360062 -- 5,167,196(+) gtgag(A/G)gattg intron-variant
rs1360063 -- 5,167,649(+) TGGCC(A/G)CGCTA intron-variant
rs1581927 -- 5,177,462(+) ttcga(C/T)acaca intron-variant
rs1590803 -- 5,177,533(+) acaga(C/T)tctgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for INSL6 Gene

Variant ID Type Subtype PubMed ID
nsv892136 CNV Gain 21882294
nsv527495 CNV Gain 19592680
nsv466100 CNV Gain 19166990
dgv8017n71 CNV Loss 21882294
dgv8018n71 CNV Loss 21882294
nsv892141 CNV Gain 21882294
nsv831495 CNV Loss 17160897
nsv892143 CNV Loss 21882294
nsv525777 CNV Loss 19592680
nsv892144 CNV Gain 21882294

Relevant External Links for INSL6 Gene

HapMap Linkage Disequilibrium report
INSL6
Human Gene Mutation Database (HGMD)
INSL6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INSL6 Gene

Disorders for INSL6 Gene

(1) University of Copenhagen DISEASES for INSL6 Gene

Relevant External Links for INSL6

Genetic Association Database (GAD)
INSL6
genes like me logo Genes that share disorders with INSL6: view

No data available for UniProtKB/Swiss-Prot for INSL6 Gene

Publications for INSL6 Gene

  1. Identification of INSL6, a new member of the insulin family that is expressed in the testis of the human and Rat. (PMID: 10819760) Lok S. … Jaspers S.R. (Biol. Reprod. 2000) 2 3 4 23
  2. Cloning of two novel mammalian paralogs of relaxin/insulin family proteins and their expression in testis and kidney. (PMID: 10598589) Hsu S.Y. (Mol. Endocrinol. 1999) 3 4 23
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population. (PMID: 19915573) Asano K. … Kubo M. (Nat. Genet. 2009) 3 48

Products for INSL6 Gene

Sources for INSL6 Gene

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