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Aliases for INSL6 Gene

Aliases for INSL6 Gene

  • Insulin Like 6 2 3 5
  • Relaxin/Insulin-Like Factor 1 2 3 4
  • Insulin-Like Peptide 6 3 4
  • Insulin-Like 6 2 3
  • RIF1 3 4
  • Insulin-Like Peptide 5 3

External Ids for INSL6 Gene

Previous GeneCards Identifiers for INSL6 Gene

  • GC09M005317
  • GC09M005145
  • GC09M005153
  • GC09M005119
  • GC09M005163
  • GC09M005141

Summaries for INSL6 Gene

Entrez Gene Summary for INSL6 Gene

  • The protein encoded by this gene contains a classical signature of the insulin superfamily and is significantly similar to relaxin and relaxin-like factor. This gene is preferentially expressed in testis. Its expression in testis is restricted to interstitial cells surrounding seminiferous tubules, which suggests a role in sperm development and fertilization. [provided by RefSeq, Jul 2008]

GeneCards Summary for INSL6 Gene

INSL6 (Insulin Like 6) is a Protein Coding gene. GO annotations related to this gene include hormone activity.

UniProtKB/Swiss-Prot for INSL6 Gene

  • May have a role in sperm development and fertilization.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INSL6 Gene

Genomics for INSL6 Gene

Regulatory Elements for INSL6 Gene

Enhancers for INSL6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around INSL6 on UCSC Golden Path with GeneCards custom track

Genomic Location for INSL6 Gene

4,991,949 bp from pter
5,185,710 bp from pter
193,762 bases
Minus strand

Genomic View for INSL6 Gene

Genes around INSL6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INSL6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INSL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INSL6 Gene

Proteins for INSL6 Gene

  • Protein details for INSL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Insulin-like peptide INSL6
    Protein Accession:
    Secondary Accessions:
    • A0AVS0
    • Q9NS16

    Protein attributes for INSL6 Gene

    213 amino acids
    Molecular mass:
    24860 Da
    Quaternary structure:
    No Data Available

neXtProt entry for INSL6 Gene

Proteomics data for INSL6 Gene at MOPED

Post-translational modifications for INSL6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for INSL6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for INSL6 Gene

Domains & Families for INSL6 Gene

Protein Domains for INSL6 Gene

Suggested Antigen Peptide Sequences for INSL6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the insulin family.
  • Belongs to the insulin family.
genes like me logo Genes that share domains with INSL6: view

No data available for Gene Families for INSL6 Gene

Function for INSL6 Gene

Molecular function for INSL6 Gene

GENATLAS Biochemistry:
insulin-like 6,expressed in the testis
UniProtKB/Swiss-Prot Function:
May have a role in sperm development and fertilization.
genes like me logo Genes that share phenotypes with INSL6: view

Animal Models for INSL6 Gene

MGI Knock Outs for INSL6:

Animal Model Products

  • Taconic Biosciences Mouse Models for INSL6

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for INSL6 Gene

Localization for INSL6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for INSL6 Gene


Subcellular locations from

Jensen Localization Image for INSL6 Gene COMPARTMENTS Subcellular localization image for INSL6 gene
Compartment Confidence
extracellular 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for INSL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with INSL6: view

Pathways & Interactions for INSL6 Gene

SuperPathways for INSL6 Gene

No Data Available

Interacting Proteins for INSL6 Gene

Gene Ontology (GO) - Biological Process for INSL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007286 spermatid development IEA --
GO:0008150 biological_process ND --
GO:0008584 male gonad development IEA --
GO:0009566 fertilization IEA --
GO:0030317 sperm motility IEA --
genes like me logo Genes that share ontologies with INSL6: view

No data available for Pathways by source and SIGNOR curated interactions for INSL6 Gene

Drugs & Compounds for INSL6 Gene

No Compound Related Data Available

Transcripts for INSL6 Gene

mRNA/cDNA for INSL6 Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for INSL6 Gene

Insulin-like 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for INSL6 Gene

No ASD Table

Relevant External Links for INSL6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for INSL6 Gene

mRNA expression in normal human tissues for INSL6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for INSL6 Gene

This gene is overexpressed in Testis (x47.1).

Protein differential expression in normal tissues from HIPED for INSL6 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for INSL6 Gene

SOURCE GeneReport for Unigene cluster for INSL6 Gene Hs.632648

mRNA Expression by UniProt/SwissProt for INSL6 Gene

Tissue specificity: Testis specific.
genes like me logo Genes that share expression patterns with INSL6: view

Protein tissue co-expression partners for INSL6 Gene

- Elite partner

Primer Products

Orthologs for INSL6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for INSL6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia INSL6 35
  • 79.23 (n)
  • 66.12 (a)
INSL6 36
  • 62 (a)
(Canis familiaris)
Mammalia INSL6 35
  • 80.16 (n)
  • 67.14 (a)
INSL6 36
  • 66 (a)
(Mus musculus)
Mammalia Insl6 35
  • 67.64 (n)
  • 47.95 (a)
Insl6 16
Insl6 36
  • 46 (a)
(Pan troglodytes)
Mammalia INSL6 35
  • 99.06 (n)
  • 97.65 (a)
INSL6 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Insl6 35
  • 65.1 (n)
  • 48.24 (a)
Species with no ortholog for INSL6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for INSL6 Gene

Gene Tree for INSL6 (if available)
Gene Tree for INSL6 (if available)

Paralogs for INSL6 Gene

No data available for Paralogs for INSL6 Gene

Variants for INSL6 Gene

Sequence variations from dbSNP and Humsavar for INSL6 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs2149554 - 5,185,365(+) TTCGA(A/G)CTGGT nc-transcript-variant, reference, missense
rs1268767 -- 5,133,035(+) ATATT(C/T)TTTCT intron-variant
rs1328919 -- 5,166,548(+) GCTTA(C/T)ACATT intron-variant
rs7469563 -- 5,139,489(+) GTATT(A/G)GGTGA intron-variant
rs1360061 -- 5,147,956(+) TGGAT(A/G)CCTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for INSL6 Gene

Variant ID Type Subtype PubMed ID
nsv892136 CNV Gain 21882294
nsv527495 CNV Gain 19592680
nsv466100 CNV Gain 19166990
dgv8017n71 CNV Loss 21882294
dgv8018n71 CNV Loss 21882294
nsv892141 CNV Gain 21882294
nsv831495 CNV Loss 17160897
nsv892143 CNV Loss 21882294
nsv525777 CNV Loss 19592680
nsv892144 CNV Gain 21882294

Variation tolerance for INSL6 Gene

Residual Variation Intolerance Score: 79.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.98; 68.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for INSL6 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INSL6 Gene

Disorders for INSL6 Gene

Relevant External Links for INSL6

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for INSL6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for INSL6 Gene

Publications for INSL6 Gene

  1. Identification of INSL6, a new member of the insulin family that is expressed in the testis of the human and Rat. (PMID: 10819760) Lok S. … Jaspers S.R. (Biol. Reprod. 2000) 2 3 4 23 67
  2. Cloning of two novel mammalian paralogs of relaxin/insulin family proteins and their expression in testis and kidney. (PMID: 10598589) Hsu S.Y. (Mol. Endocrinol. 1999) 3 23
  3. A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population. (PMID: 19915573) Asano K. … Kubo M. (Nat. Genet. 2009) 3
  4. Levonorgestrel enhances spermatogenesis suppression by testosterone with greater alteration in testicular gene expression in men. (PMID: 19074003) Lue Y. … Swerdloff R.S. (Biol. Reprod. 2009) 23
  5. A fat body-derived IGF-like peptide regulates postfeeding growth in Drosophila. (PMID: 20059957) Okamoto N. … Mizoguchi A. (Dev. Cell 2009) 23

Products for INSL6 Gene

Sources for INSL6 Gene