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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

INSL6 Gene

protein-coding   GIFtS: 49
GCID: GC09M005163

Insulin-Like 6

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Insulin-Like 61 2
Relaxin/Insulin-Like Factor 11 2 3
Insulin-Like Peptide 62 3
RIF12 3
Insulin-Like Peptide 52
Insulin-Like Peptide INSL62

External Ids:    HGNC: 60891   Entrez Gene: 111722   Ensembl: ENSG000001202107   OMIM: 6064145   UniProtKB: Q9Y5813   

Export aliases for INSL6 gene to outside databases

Previous GC identifers: GC09M005317 GC09M005145 GC09M005153 GC09M005119


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for INSL6 Gene:
The protein encoded by this gene contains a classical signature of the insulin superfamily and is significantly
similar to relaxin and relaxin-like factor. This gene is preferentially expressed in testis. Its expression in
testis is restricted to interstitial cells surrounding seminiferous tubules, which suggests a role in sperm
development and fertilization. (provided by RefSeq, Jul 2008)

GeneCards Summary for INSL6 Gene: 
INSL6 (insulin-like 6) is a protein-coding gene. Diseases associated with INSL6 include cryptorchidism, and ulcerative colitis. GO annotations related to this gene include hormone activity.

UniProtKB/Swiss-Prot: INSL6_HUMAN, Q9Y581
Function: May have a role in sperm development and fertilization




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008413.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the INSL6 gene promoter:
         LHX3b/Lhx3b   Pax-2   Pax-2a   CUTL1   E2F-1   E2F   Pax-2b   LHX3a/Lhx3a   IRF-7A   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidINSL6 promoter sequence
   Search SABiosciences Chromatin IP Primers for INSL6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INSL6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p24   Ensembl cytogenetic band:  9p24.1   HGNC cytogenetic band: 9p24

INSL6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INSL6 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M005163:  view genomic region     (about GC identifiers)

Start:
5,131,979 bp from pter      End:
5,185,668 bp from pter
Size:
53,690 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: INSL6_HUMAN, Q9Y581 (See protein sequence)
Recommended Name: Insulin-like peptide INSL6 precursor  
Size: 213 amino acids; 24860 Da
Subcellular location: Secreted (By similarity)
Secondary accessions: A0AVS0 Q9NS16

Explore the universe of human proteins at neXtProt for INSL6: NX_Q9Y581

Explore proteomics data for INSL6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y581

  • INSL6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    INSL6 Protein Expression
    REFSEQ proteins: NP_009110.2  
    ENSEMBL proteins: 
     ENSP00000371054  

    Human Recombinant Protein Products for INSL6: 
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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005576extracellular region IEA--

    INSL6 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR016179 Insulin-like
     IPR022353 Insulin_CS
     IPR017100 Insulin-like_pep_6

    Graphical View of Domain Structure for InterPro Entry Q9Y581

    ProtoNet protein and cluster: Q9Y581

    1 Blocks protein domain: IPB004825 Insulin/IGF/relaxin

    UniProtKB/Swiss-Prot: INSL6_HUMAN, Q9Y581
    Similarity: Belongs to the insulin family


    INSL6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: INSL6_HUMAN, Q9Y581
    Function: May have a role in sperm development and fertilization

         Genatlas biochemistry entry for INSL6:
    insulin-like 6,expressed in the testis

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005179hormone activity NAS10598589
         
    INSL6 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for INSL6:
     Increased G1 DNA content 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Insl6):
     cellular  endocrine/exocrine gland  reproductive system 

    INSL6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Insl6tm1Imad for INSL6

       inGenious Targeting Laboratory - Custom generated mouse model solutions for INSL6 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for INSL6

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for INSL6

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0007283spermatogenesis ----
    GO:0007286spermatid development IEA--
    GO:0008150biological_process ND--
    GO:0008584male gonad development IEA--

    INSL6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for INSL6

    Search CenterWatch for drugs/clinical trials and news about INSL6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for INSL6 gene: 
    NM_007179.2  

    Unigene Cluster for INSL6:

    Insulin-like 6
    Hs.632648  [show with all ESTs]
    Unigene Representative Sequence: BQ429291
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000510407 ENST00000381641(uc003zix.3)
    miRNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INSL6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INSL6

    Additional mRNA sequence: 

    AF135824.1 AF156094.1 BC126473.1 BC126475.1 

    1 DOTS entry:

    DT.40287037 

    16 AceView cDNA sequences:

    AW188252 BX103932 AW663052 AW117587 NM_007179 BX098775 AF156094 AF135824 
    AW628986 AI215096 AW183490 AW269572 AI553950 AI743479 T19007 AA907071 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    INSL6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAATGCATT
    INSL6 Expression
    About this image


    See INSL6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for INSL6

    SOURCE GeneReport for Unigene cluster: Hs.632648

    UniProtKB/Swiss-Prot: INSL6_HUMAN, Q9Y581
    Tissue specificity: Testis specific

        SABiosciences Custom PCR Arrays for INSL6
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INSL6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for INSL6 gene from 1/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Insl61 , 5 insulin-like 61, 5 67.55(n)1
    48.68(a)1
      19 (23.82 cM)5
    273561  NM_013754.11  NP_038782.11 
     293213445 


    ENSEMBL Gene Tree for INSL6 (if available)
    TreeFam Gene Tree for INSL6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/734 SNPs in INSL6 are shown (see all 734)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1891081581,2
    --5163414(+) AAACTA/GACTAC 1 -- ds50010--------
    rs123533711,2
    C,F,H--5163459(+) CTATTA/GCAGCA 1 -- ds50014Minor allele frequency- G:0.00NS EA 418
    rs768143691,2
    C,F--5163520(+) GGACAG/CATGGG 1 -- ds50011Minor allele frequency- C:0.03WA 118
    rs1810822091,2
    --5163524(+) AGATGG/TGTCGA 1 -- ds50010--------
    rs1848678111,2
    --5163558(+) AACAGC/TCATGG 1 -- ds50010--------
    rs347723391,2
    C--5163633(+) TAAGACTT/-GAGTT 1 -- cds11Minor allele frequency- -:0.00CSA 2
    rs107586741,2
    C,F,A,H--5163645(+) CAACCA/C/GTAATG 1 -- ds500123NS EA NA WA CSA 2351
    rs1433244191,2
    C--5163750(+) CCAAAG/TAAAAT 1 -- ds50010--------
    rs776522611,2
    C--5163778(+) CACTAA/TAAGGT 1 -- ds50010--------
    rs1897452941,2
    --5163798(+) TGCTTG/TCAAGT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for INSL6 (5131979 - 5185668 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for INSL6:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv831495CNV Loss17160897
    dgv8017n71CNV Loss21882294
    nsv525777CNV Loss19592680
    nsv892143CNV Loss21882294
    dgv8018n71CNV Loss21882294
    nsv892136CNV Gain21882294
    nsv466100CNV Gain19166990
    nsv527495CNV Gain19592680
    nsv892144CNV Gain21882294
    nsv892141CNV Gain21882294


    Human Gene Mutation Database (HGMD): INSL6
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for INSL6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606414    OMIM disorders: --

    2 diseases for INSL6:    About MalaCards
    cryptorchidism    ulcerative colitis

    1 disease from the University of Copenhagen DISEASES database for INSL6:
    Cryptorchidism

    INSL6 for disorders           About GeneDecksing

    Genetic Association Database (GAD): INSL6

    Export disorders for INSL6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for INSL6 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with INSL6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of INSL6, a new member of the insulin family that is expressed in the testis of the human and Rat. (PubMed id 10819760)1, 2, 3, 9 Lok S....Jaspers S.R. (2000)
    2. Cloning of two novel mammalian paralogs of relaxin/insulin family proteins and their expression in testis and kidney. (PubMed id 10598589)1, 2, 9 Hsu S.Y. (1999)
    3. A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population. (PubMed id 19915573)1, 4 Asano K....Kubo M. (2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    7. Insulin-like peptide 6: characterization of secretory status and posttranslational modifications. (PubMed id 16935843)9 Lu C....Menon R.K. (2006)
    8. A fat body-derived IGF-like peptide regulates postfee ding growth in Drosophila. (PubMed id 20059957)9 Okamoto N....Mizoguchi A. (2009)
    9. Levonorgestrel enhances spermatogenesis suppression by testosterone with greater alteration in testicular gene expression in men. (PubMed id 19074003)9 Lue Y....Swerdloff R.S. (2009)
    10. Evolution of the relaxin-like peptide family: from neuropeptide to reproduction. (PubMed id 15956756)9 Wilkinson T.N....Bathgate R.A. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11172 HGNC: 6089 AceView: INSL6 Ensembl:ENSG00000120210 euGenes: HUgn11172
    ECgene: INSL6 H-InvDB: INSL6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for INSL6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for INSL6 gene:
    Search GeneIP for patents involving INSL6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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