INSL6 Gene
protein-coding GIFtS: 46
GCID: GC09M005163
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insulin-like 6
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Aliases
for INSL6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Insulin-Like 61 2 | | RIF11 2 3 | | Insulin-Like Peptide 62 3 | | Relaxin/Insulin-Like Factor 12 3 | | Insulin-Like Peptide 52 | | Insulin-Like Peptide INSL62 |
Export aliases for INSL6 gene to outside databasesPrevious GC identifers: GC09M005317 GC09M005145 GC09M005153 GC09M005119 |
Summaries
for INSL6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for INSL6:
The protein encoded by this gene contains a classical signature of the insulin superfamily and is significantly similarto relaxin and relaxin-like factor. This gene is preferentially expressed in testis. Its expression in testis isrestricted to interstitial cells surrounding seminiferous tubules, which suggests a role in sperm development andfertilization. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: INSL6_HUMAN, Q9Y581Function: May have a role in sperm development and fertilization
|
Genomic Views
for INSL6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008413.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the INSL6 gene promoter:
LHX3b/Lhx3b Pax-2 Pax-2a CUTL1 E2F-1 E2F Pax-2b LHX3a/Lhx3a IRF-7A Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for INSL6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INSL6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9p24 Ensembl cytogenetic band: 9p24.1 HGNC cytogenetic band: 9p24INSL6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M005163: view genomic region
(about GC identifiers)
Start:
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5,163,863 bp from pter |
End:
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5,185,668 bp from pter |
Size:
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21,806 bases |
Orientation:
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minus strand |
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Proteins
for INSL6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: INSL6_HUMAN, Q9Y581 (See
protein sequence)Recommended Name: Insulin-like peptide INSL6 precursor Size: 213 amino acids; 24860 Da
Subcellular location: Secreted (By similarity)
Secondary accessions: A0AVS0 Q9NS16Explore the universe of human proteins at neXtProt for INSL6: NX_Q9Y581
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y581
INSL6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_009110.2
ENSEMBL proteins: ENSP00000371054
Human Recombinant Protein Products for INSL6:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- | | GO:0005576 | extracellular region |
IEA | -- |
INSL6 for ontologies About GeneDecksing
INSL6 Antibody Products:
Assay Products for INSL6: |
Protein
Domains /
Families
for INSL6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
INSL6 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y581ProtoNet protein and cluster: Q9Y581 1 Blocks protein family: IPB004825 Insulin/IGF/relaxin
UniProtKB/Swiss-Prot: INSL6_HUMAN, Q9Y581Similarity: Belongs to the insulin family |
Function
for INSL6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: INSL6_HUMAN, Q9Y581Function: May have a role in sperm development and fertilization Genatlas biochemistry entry for INSL6:insulin-like 6,expressed in the testis
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
INSL6 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for INSL6:
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Insl6):
INSL6 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Insl6tm1Imad for INSL6
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for INSL6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for INSL6
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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Synthesis Service for INSL6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INSL6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INSL6 |
|
Pathways & Interactions
for INSL6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for INSL6
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table
INSL6 for ontologies About GeneDecksing
|
Drugs & Compounds
for INSL6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for INSL6
Search CenterWatch for drugs/clinical trials and news about INSL6
|
Transcripts
for INSL6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for INSL6 gene: NM_007179.2 Unigene Cluster for INSL6: Insulin-like 6 Hs.632648 [show with all ESTs]Unigene Representative Sequence: BQ4292911 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000381641(uc003zix.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for INSL6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for INSL6
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: INSL6 (NM_007179) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for INSL6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INSL6 |
Additional cDNA sequence: AF135824.1 AF156094.1 BC126473.1 BC126475.1 1 DOTS entry: DT.40287037 16 AceView cDNA sequences: AW663052 AI215096 AW188252 AF135824 BX098775 AF156094 AW628986 NM_007179 BX103932 AW117587 AI743479 AI553950 AW183490 AW269572 T19007 AA907071
GeneLoc Exon Structure
|
Expression
for INSL6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| INSL6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAATGCATT
About this image
See INSL6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for INSL6
SOURCE GeneReport for Unigene cluster: Hs.632648
UniProtKB/Swiss-Prot: INSL6_HUMAN, Q9Y581Tissue specificity: Testis specific
SABiosciences Custom PCR Arrays for INSL6
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for INSL6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat INSL6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INSL6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INSL6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INSL6 |
Orthologs
for INSL6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for INSL6 gene from 1/5 species (see all 5) About this table
ENSEMBL Gene Tree for INSL6 (if available)
TreeFam Gene Tree for INSL6 (if available) |
Paralogs
for INSL6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for INSL6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for INSL6 (5163863 - 5185668 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for INSL6: --
Human Gene Mutation Database (HGMD): INSL6
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing INSL6 |
|
Disorders
/ Diseases
for INSL6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
INSL6 for disorders About GeneDecksing
OMIM gene information: 606414
OMIM disorders: --
2  diseases for INSL6: About MalaCardsulcerative colitis cryptorchidism
1 disease from the University of Copenhagen DISEASES database for INSL6:Cryptorchidism Export disorders for INSL6 gene to outside databases
|
Publications
for INSL6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for INSL6 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with INSL6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of INSL6, a new member of the insulin family that is expressed in the testis of the human and Rat. (PubMed id 10819760)1, 2, 3, 9 Lok S....Jaspers S.R. (2000)
- Cloning of two novel mammalian paralogs of relaxin/insulin family proteins and their expression in testis and kidney. (PubMed id 10598589)1, 2, 9 Hsu S.Y. (1999)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
- A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population. (PubMed id 19915573)1 Asano K....Kubo M. (2009)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Insulin-like peptide 6: characterization of secretory status and posttranslational modifications. (PubMed id 16935843)9 Lu C....Menon R.K. (2006)
- A fat body-derived IGF-like peptide regulates postfee ding growth in Drosophila. (PubMed id 20059957)9 Okamoto N....Mizoguchi A. (2009)
- Levonorgestrel enhances spermatogenesis suppression by testosterone with greater alteration in testicular gene expression in men. (PubMed id 19074003)9 Lue Y....Swerdloff R.S. (2009)
- Evolution of the relaxin-like peptide family: from neuropeptide to reproduction. (PubMed id 15956756)9 Wilkinson T.N....Bathgate R.A. (2005)
|
External Searches for INSL6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing INSL6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing INSL6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing INSL6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for INSL6 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for INSL6 gene:
Search GeneIP for patents involving INSL6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for INSL6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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 | | | INSL6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INSL6 |
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