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Aliases for INSL5 Gene

Aliases for INSL5 Gene

  • Insulin-Like 5 2 3
  • Insulin-Like Peptide 5 3 4
  • Prepro-INSL5 2 3
  • Insulin-Like Peptide INSL5 3
  • PRO182 3
  • UNQ156 3

External Ids for INSL5 Gene

Previous GeneCards Identifiers for INSL5 Gene

  • GC01M067223
  • GC01M066194
  • GC01M066621
  • GC01M066633
  • GC01M066975
  • GC01M065371

Summaries for INSL5 Gene

Entrez Gene Summary for INSL5 Gene

  • The protein encoded by this gene contains a classical signature of the insulin superfamily and is highly similar to relaxin 3 (RLN3/INSL7). [provided by RefSeq, Jul 2008]

GeneCards Summary for INSL5 Gene

INSL5 (Insulin-Like 5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include hormone activity.

UniProtKB/Swiss-Prot for INSL5 Gene

  • May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor

Gene Wiki entry for INSL5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INSL5 Gene

Genomics for INSL5 Gene

Regulatory Elements for INSL5 Gene

Genomic Location for INSL5 Gene

66,797,741 bp from pter
66,801,259 bp from pter
3,519 bases
Minus strand

Genomic View for INSL5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for INSL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INSL5 Gene

Proteins for INSL5 Gene

  • Protein details for INSL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Insulin-like peptide INSL5
    Protein Accession:
    Secondary Accessions:
    • Q3MIY4
    • Q5VYD8

    Protein attributes for INSL5 Gene

    135 amino acids
    Molecular mass:
    15333 Da
    Quaternary structure:
    • Heterodimer of a B chain and an A chain linked by two disulfide bonds

    Three dimensional structures from OCA and Proteopedia for INSL5 Gene

neXtProt entry for INSL5 Gene

Proteomics data for INSL5 Gene at MOPED

Post-translational modifications for INSL5 Gene

No Post-translational modifications

Other Protein References for INSL5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for INSL5 Gene

Domains for INSL5 Gene

Gene Families for INSL5 Gene


Protein Domains for INSL5 Gene


Suggested Antigen Peptide Sequences for INSL5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9Y5Q6
  • Belongs to the insulin family.
genes like me logo Genes that share domains with INSL5: view

Function for INSL5 Gene

Molecular function for INSL5 Gene

GENATLAS Biochemistry: insulin-like 5,expressed in rectal,colon and uterine tissue
UniProtKB/Swiss-Prot Function: May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor

Gene Ontology (GO) - Molecular Function for INSL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity IEA --
genes like me logo Genes that share ontologies with INSL5: view
genes like me logo Genes that share phenotypes with INSL5: view

Animal Models for INSL5 Gene

MGI Knock Outs for INSL5:

Animal Model Products

CRISPR Products

miRNA for INSL5 Gene

miRTarBase miRNAs that target INSL5

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for INSL5 Gene

Localization for INSL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for INSL5 Gene


Subcellular locations from

Jensen Localization Image for INSL5 Gene COMPARTMENTS Subcellular localization image for INSL5 gene
Compartment Confidence
extracellular 5
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for INSL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with INSL5: view

Pathways for INSL5 Gene

genes like me logo Genes that share pathways with INSL5: view

Interacting Proteins for INSL5 Gene

Gene Ontology (GO) - Biological Process for INSL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with INSL5: view

Transcripts for INSL5 Gene

mRNA/cDNA for INSL5 Gene

(3) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for INSL5

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for INSL5
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for INSL5 Gene

No ASD Table

Relevant External Links for INSL5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for INSL5 Gene

mRNA expression in normal human tissues for INSL5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for INSL5 Gene

This gene is overexpressed in Colon - Sigmoid (14.6) and Colon - Transverse (10.7).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for INSL5 Gene

SOURCE GeneReport for Unigene cluster for INSL5 Gene Hs.251380

mRNA Expression by UniProt/SwissProt for INSL5 Gene

Tissue specificity: Highly expressed in rectum with lower levels in uterus and ascending and descending colon.
genes like me logo Genes that share expressions with INSL5: view

In Situ Assay Products

Orthologs for INSL5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for INSL5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia INSL5 35
  • 99.26 (n)
  • 98.52 (a)
INSL5 36
  • 99 (a)
(Bos Taurus)
Mammalia INSL5 35
  • 76.3 (n)
  • 68.15 (a)
INSL5 36
  • 55 (a)
(Mus musculus)
Mammalia Insl5 35
  • 69.14 (n)
  • 57.78 (a)
Insl5 16
Insl5 36
  • 58 (a)
Species with no ortholog for INSL5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for INSL5 Gene

Gene Tree for INSL5 (if available)
Gene Tree for INSL5 (if available)

Paralogs for INSL5 Gene

No data available for Paralogs for INSL5 Gene

Variants for INSL5 Gene

Sequence variations from dbSNP and Humsavar for INSL5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs471830 -- 66,799,725(-) aaaat(G/T)atata intron-variant
rs484287 -- 66,801,676(-) gctgg(G/T)cttga upstream-variant-2KB
rs496668 -- 66,799,383(+) tgata(C/T)gtgga intron-variant
rs497710 -- 66,799,248(+) CATAT(A/G)GTCGC intron-variant
rs502340 -- 66,798,721(+) GTTCA(C/T)ATATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for INSL5 Gene

Variant ID Type Subtype PubMed ID
nsv830093 CNV Gain 17160897

Relevant External Links for INSL5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INSL5 Gene

Disorders for INSL5 Gene

(1) University of Copenhagen DISEASES for INSL5 Gene

Relevant External Links for INSL5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with INSL5: view

No data available for UniProtKB/Swiss-Prot for INSL5 Gene

Publications for INSL5 Gene

  1. Identification of INSL5, a new member of the insulin superfamily. (PMID: 10458910) Conklin D. … Jaspers S. (Genomics 1999) 2 3 4 23
  2. INSL5 is a high affinity specific agonist for GPCR142 (GPR100). (PMID: 15525639) Liu C. … Lovenberg T.W. (J. Biol. Chem. 2005) 3 4 23
  3. Structure of human insulin-like peptide 5 and characterization of conserved hydrogen bonds and electrostatic interactions within the relaxin framework. (PMID: 19178384) Haugaard-Joensson L.M. … Rosengren K.J. (Biochem. J. 2009) 3 4 23
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4

Products for INSL5 Gene

Sources for INSL5 Gene

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