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Aliases for INSL5 Gene

Aliases for INSL5 Gene

  • Insulin Like 5 2 3 5
  • Insulin-Like Peptide 5 3 4
  • Prepro-INSL5 2 3
  • Insulin-Like Peptide INSL5 3
  • Insulin-Like 5 2
  • PRO182 3
  • UNQ156 3

External Ids for INSL5 Gene

Previous GeneCards Identifiers for INSL5 Gene

  • GC01M067223
  • GC01M066194
  • GC01M066621
  • GC01M066633
  • GC01M066975
  • GC01M065371

Summaries for INSL5 Gene

Entrez Gene Summary for INSL5 Gene

  • The protein encoded by this gene contains a classical signature of the insulin superfamily and is highly similar to relaxin 3 (RLN3/INSL7). [provided by RefSeq, Jul 2008]

GeneCards Summary for INSL5 Gene

INSL5 (Insulin Like 5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include hormone activity.

UniProtKB/Swiss-Prot for INSL5 Gene

  • May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor.

Gene Wiki entry for INSL5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INSL5 Gene

Genomics for INSL5 Gene

Regulatory Elements for INSL5 Gene

Enhancers for INSL5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F067194 1.3 FANTOM5 ENCODE 1.3 -393.6 -393639 1.5 HDGF PKNOX1 ATF1 MXI1 TBL1XR1 TAL1 BMI1 YY1 NCOR1 NR2F6 C1orf141 IL23R SLC35D1 WDR78 IL12RB2 MIER1 INSL5 RNU6-586P GC01M067171
GH01F066788 0.5 Ensembl 0.4 +12.6 12559 0.6 EGR1 CBFB RELA INSL5 TCTEX1D1
GH01F066761 0.5 Ensembl 0.3 +39.8 39759 0.2 TCTEX1D1 INSL5
GH01F066769 0.9 Ensembl ENCODE 0.3 +31.4 31381 0.7 IRF2 IRF1 TCTEX1D1 INSL5
GH01F066757 1 FANTOM5 Ensembl ENCODE 0.2 +42.9 42926 1.8 TBP HDAC1 PKNOX1 CBX3 ATF1 ARNT TBL1XR1 CHAMP1 GATA2 CREM TCTEX1D1 SGIP1 MIER1 INSL5
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around INSL5 on UCSC Golden Path with GeneCards custom track

Genomic Location for INSL5 Gene

Chromosome:
1
Start:
66,797,741 bp from pter
End:
66,801,259 bp from pter
Size:
3,519 bases
Orientation:
Minus strand

Genomic View for INSL5 Gene

Genes around INSL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INSL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INSL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INSL5 Gene

Proteins for INSL5 Gene

  • Protein details for INSL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5Q6-INSL5_HUMAN
    Recommended name:
    Insulin-like peptide INSL5
    Protein Accession:
    Q9Y5Q6
    Secondary Accessions:
    • Q3MIY4
    • Q5VYD8

    Protein attributes for INSL5 Gene

    Size:
    135 amino acids
    Molecular mass:
    15333 Da
    Quaternary structure:
    • Heterodimer of a B chain and an A chain linked by two disulfide bonds.

    Three dimensional structures from OCA and Proteopedia for INSL5 Gene

neXtProt entry for INSL5 Gene

Post-translational modifications for INSL5 Gene

No Post-translational modifications

Other Protein References for INSL5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for INSL5
  • Santa Cruz Biotechnology (SCBT) Antibodies for INSL5

No data available for DME Specific Peptides for INSL5 Gene

Domains & Families for INSL5 Gene

Gene Families for INSL5 Gene

Protein Domains for INSL5 Gene

Suggested Antigen Peptide Sequences for INSL5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y5Q6

UniProtKB/Swiss-Prot:

INSL5_HUMAN :
  • Belongs to the insulin family.
Family:
  • Belongs to the insulin family.
genes like me logo Genes that share domains with INSL5: view

Function for INSL5 Gene

Molecular function for INSL5 Gene

GENATLAS Biochemistry:
insulin-like 5,expressed in rectal,colon and uterine tissue
UniProtKB/Swiss-Prot Function:
May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor.

Gene Ontology (GO) - Molecular Function for INSL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IBA --
GO:0005179 hormone activity IBA --
genes like me logo Genes that share ontologies with INSL5: view
genes like me logo Genes that share phenotypes with INSL5: view

Animal Models for INSL5 Gene

MGI Knock Outs for INSL5:

Animal Model Products

  • Taconic Biosciences Mouse Models for INSL5

miRNA for INSL5 Gene

miRTarBase miRNAs that target INSL5

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for INSL5 Gene

Localization for INSL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for INSL5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for INSL5 Gene COMPARTMENTS Subcellular localization image for INSL5 gene
Compartment Confidence
extracellular 5
nucleus 1

Gene Ontology (GO) - Cellular Components for INSL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with INSL5: view

Pathways & Interactions for INSL5 Gene

genes like me logo Genes that share pathways with INSL5: view

Interacting Proteins for INSL5 Gene

Selected Interacting proteins: Q9Y5Q6-INSL5_HUMAN for INSL5 Gene via IID

Symbol External ID(s) Details
LEP
RLN1

Gene Ontology (GO) - Biological Process for INSL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:2000253 positive regulation of feeding behavior IBA --
genes like me logo Genes that share ontologies with INSL5: view

No data available for SIGNOR curated interactions for INSL5 Gene

Transcripts for INSL5 Gene

mRNA/cDNA for INSL5 Gene

(1) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for INSL5 Gene

No ASD Table

Relevant External Links for INSL5 Gene

GeneLoc Exon Structure for
INSL5
ECgene alternative splicing isoforms for
INSL5

Expression for INSL5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for INSL5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for INSL5 Gene

This gene is overexpressed in Colon - Sigmoid (x14.6) and Colon - Transverse (x10.7).

Protein differential expression in normal tissues from HIPED for INSL5 Gene

This gene is overexpressed in Rectum (34.7) and Colon (34.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for INSL5 Gene



Protein tissue co-expression partners for INSL5 Gene

NURSA nuclear receptor signaling pathways regulating expression of INSL5 Gene:

INSL5

SOURCE GeneReport for Unigene cluster for INSL5 Gene:

Hs.251380

mRNA Expression by UniProt/SwissProt for INSL5 Gene:

Q9Y5Q6-INSL5_HUMAN
Tissue specificity: Highly expressed in rectum with lower levels in uterus and ascending and descending colon.
genes like me logo Genes that share expression patterns with INSL5: view

Primer Products

Orthologs for INSL5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for INSL5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INSL5 34 35
  • 99.26 (n)
cow
(Bos Taurus)
Mammalia INSL5 34 35
  • 76.3 (n)
mouse
(Mus musculus)
Mammalia Insl5 34 16 35
  • 69.14 (n)
Species where no ortholog for INSL5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for INSL5 Gene

ENSEMBL:
Gene Tree for INSL5 (if available)
TreeFam:
Gene Tree for INSL5 (if available)

Paralogs for INSL5 Gene

No data available for Paralogs for INSL5 Gene

Variants for INSL5 Gene

Sequence variations from dbSNP and Humsavar for INSL5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs111227114 -- 66,799,348(+) CAAGG(C/T)ACAGA intron-variant
rs112644946 -- 66,800,942(+) TCAAC(A/G)GTACT intron-variant
rs113340351 -- 66,801,753(+) CTTGA(A/G)CCCAG upstream-variant-2KB
rs113720094 -- 66,801,390(+) GTTTT(A/G)AAAAT upstream-variant-2KB
rs11394371 -- 66,797,364(+) AAAAA(-/A)GTTAT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for INSL5 Gene

Variant ID Type Subtype PubMed ID
esv3893623 CNV gain 25118596
nsv830093 CNV gain 17160897

Variation tolerance for INSL5 Gene

Residual Variation Intolerance Score: 83.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.44; 9.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for INSL5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
INSL5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INSL5 Gene

Disorders for INSL5 Gene

Relevant External Links for INSL5

Genetic Association Database (GAD)
INSL5
Human Genome Epidemiology (HuGE) Navigator
INSL5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
INSL5

No disorders were found for INSL5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for INSL5 Gene

Publications for INSL5 Gene

  1. Identification of INSL5, a new member of the insulin superfamily. (PMID: 10458910) Conklin D. … Jaspers S. (Genomics 1999) 2 3 4 22 64
  2. Structure of human insulin-like peptide 5 and characterization of conserved hydrogen bonds and electrostatic interactions within the relaxin framework. (PMID: 19178384) Haugaard-Joensson L.M. … Rosengren K.J. (Biochem. J. 2009) 3 4 22 64
  3. INSL5 is a high affinity specific agonist for GPCR142 (GPR100). (PMID: 15525639) Liu C. … Lovenberg T.W. (J. Biol. Chem. 2005) 3 4 22 64
  4. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 46 64
  5. Synthesis, conformation, and activity of human insulin-like peptide 5 (INSL5). (PMID: 18576448) Akhter Hossain M. … Wade J.D. (ChemBioChem 2008) 4 22 64

Products for INSL5 Gene

Sources for INSL5 Gene

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