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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

INSL5 Gene

protein-coding   GIFtS: 52
GCID: GC01M067223

Insulin-Like 5

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Insulin-Like 51 2
prepro-INSL51 2
Insulin-Like Peptide 52 3
PRO1822
UNQ1562
Insulin-Like Peptide INSL52

External Ids:    HGNC: 60881   Entrez Gene: 100222   Ensembl: ENSG000001724107   OMIM: 6064135   UniProtKB: Q9Y5Q63   

Export aliases for INSL5 gene to outside databases

Previous GC identifers: GC01M066194 GC01M066621 GC01M066633 GC01M066975 GC01M065371


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for INSL5 Gene:
The protein encoded by this gene contains a classical signature of the insulin superfamily and is highly similar
to relaxin 3 (RLN3/INSL7). (provided by RefSeq, Jul 2008)

GeneCards Summary for INSL5 Gene: 
INSL5 (insulin-like 5) is a protein-coding gene. Diseases associated with INSL5 include cryptorchidism, and among its related super-pathways are GPCR ligand binding and Signaling by GPCR. GO annotations related to this gene include hormone activity.

UniProtKB/Swiss-Prot: INSL5_HUMAN, Q9Y5Q6
Function: May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high
potency and appears to be the endogenous ligand for this receptor

Gene Wiki entry for INSL5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the INSL5 gene promoter:
         HOXA9B   HOXA9   CUTL1   Cdc5   Meis-1b   HNF-1A   Nkx6-1   HNF-1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidINSL5 promoter sequence
   Search SABiosciences Chromatin IP Primers for INSL5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INSL5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.3   Ensembl cytogenetic band:  1p31.3   HGNC cytogenetic band: 1p31.3

INSL5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INSL5 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M067223:  view genomic region     (about GC identifiers)

Start:
67,263,424 bp from pter      End:
67,266,942 bp from pter
Size:
3,519 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: INSL5_HUMAN, Q9Y5Q6 (See protein sequence)
Recommended Name: Insulin-like peptide INSL5 precursor  
Size: 135 amino acids; 15333 Da
Subunit: Heterodimer of a B chain and an A chain linked by two disulfide bonds
Subcellular location: Secreted
2 PDB 3D structures from and Proteopedia for INSL5:
2K1V (3D)        2KBC (3D)    
Secondary accessions: Q3MIY4 Q5VYD8

Explore the universe of human proteins at neXtProt for INSL5: NX_Q9Y5Q6

Explore proteomics data for INSL5 at MOPED 

INSL5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

INSL5 Protein Expression

REFSEQ proteins: NP_005469.2  
ENSEMBL proteins: 
 ENSP00000302724  
Reactome Protein details: Q9Y5Q6
Human Recombinant Protein Products for INSL5: 
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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005575cellular_component ND--
GO:0005576extracellular region TAS--

INSL5 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
ENDOLIG: Endogenous ligands

2 InterPro protein domains:
 IPR016179 Insulin-like
 IPR022353 Insulin_CS

Graphical View of Domain Structure for InterPro Entry Q9Y5Q6

ProtoNet protein and cluster: Q9Y5Q6

1 Blocks protein domain: IPB004825 Insulin/IGF/relaxin

UniProtKB/Swiss-Prot: INSL5_HUMAN, Q9Y5Q6
Similarity: Belongs to the insulin family


INSL5 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: INSL5_HUMAN, Q9Y5Q6
Function: May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high
potency and appears to be the endogenous ligand for this receptor

     Genatlas biochemistry entry for INSL5:
insulin-like 5,expressed in rectal,colon and uterine tissue

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005179hormone activity NAS--
     
INSL5 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for INSL5:
 Increased cell death HMECs cel 

     5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Insl5):
 endocrine/exocrine gland  homeostasis/metabolism  normal  renal/urinary system  reproductive system 

INSL5 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-outs for INSL5: Insl5tm1Dgen Insl5tm1Imad

   inGenious Targeting Laboratory - Custom generated mouse model solutions for INSL5 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for INSL5

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for INSL5 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for INSL5 

miRNA
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hsa-miR-137 hsa-miR-92a hsa-miR-25 hsa-miR-367 hsa-miR-32 hsa-miR-106a* hsa-miR-182 hsa-miR-363
SwitchGear 3'UTR luciferase reporter plasmidINSL5 3' UTR sequence
Inhib. RNA
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Gene Editing
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Clone
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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for INSL5 About                                                                                                See pathways by source

SuperPathContained pathways About
1Class A/1 (Rhodopsin-like receptors)
Class A/1 (Rhodopsin-like receptors)0.71
Peptide ligand-binding receptors0.60
GPCR ligand binding0.71
G alpha (i) signalling events0.46
2Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.55
GPCR downstream signaling0.90
3Relaxin receptors
Relaxin receptors

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


5/8        Reactome Pathways for INSL5 (see all 8)
    GPCR downstream signaling
Peptide ligand-binding receptors
Signal Transduction
Signaling by GPCR
G alpha (i) signalling events



INSL5 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for INSL5

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008150biological_process ND--

INSL5 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for INSL5

Search CenterWatch for drugs/clinical trials and news about INSL5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for INSL5 gene: 
NM_005478.4  

Unigene Cluster for INSL5:

Insulin-like 5
Hs.251380
Unigene Representative Sequence: AF133816
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000304526(uc001dcw.3)
miRNA
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SwitchGear 3'UTR luciferase reporter plasmidINSL5 3' UTR sequence
Inhib. RNA
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                     Customized lentivirus expression plasmids for stable overexpression of INSL5 
Primer
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SABiosciences RT2 qPCR Primer Assay in human, mouse, rat INSL5
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INSL5
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INSL5

Additional mRNA sequence: 

AF133816.2 AY359030.1 BC101646.1 BC101648.1 

1 DOTS entry:

DT.91750530 

3 AceView cDNA sequences:

NM_005478 AY359030 AF133816 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

INSL5 expression in normal human tissues (normalized intensities)      INSL5 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTTAATTACA
INSL5 Expression
About this image


INSL5 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/2 selected tissues (see all 2) fully expand
 
 Colon (Gastrointestinal Tract)    fully expand to see all 2 entries
         sigmoid colon mucosa   
 
 Eye (Sensory Organs)
         Mature Rod Cells Outer Nuclear Layer

See INSL5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for INSL5

SOURCE GeneReport for Unigene cluster: Hs.251380

UniProtKB/Swiss-Prot: INSL5_HUMAN, Q9Y5Q6
Tissue specificity: Highly expressed in rectum with lower levels in uterus and ascending and descending colon

    SABiosciences Custom PCR Arrays for INSL5
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INSL5
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INSL5

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for INSL5 gene from 1/3 species (see all 3)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Insl51 , 5 insulin-like 51, 5 69.14(n)1
57.78(a)1
  4 (47.27 cM)5
239191  NM_011831.21  NP_035961.11 
 1030178725 


ENSEMBL Gene Tree for INSL5 (if available)
TreeFam Gene Tree for INSL5 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/136 SNPs in INSL5 are shown (see all 136)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1481438501,2
--67263021(+) TCCAGA/GCTGGC 1 -- ds50010--------
rs1815913901,2
--67263026(+) ACTGGC/TGACAG 1 -- ds50010--------
rs113943711,2
C--67263047(+) AAAAAA/-GTTAT 1 -- ds50012Minor allele frequency- -:0.25NA CSA 4
rs1859087241,2
--67263155(+) GGTTCA/GCATCC 1 -- ds50010--------
rs1419865021,2
C--67263199(+) GAGAAC/TTGTCT 1 -- ds50010--------
rs1902864071,2
--67263439(+) CATTTC/TTATTG 1 -- ut310--------
rs1825600061,2
--67263453(+) TTTTGC/TGCAGC 1 -- ut310--------
rs1861807391,2
--67263466(+) TTGAAA/TTTTCA 1 -- ut310--------
rs1473271941,2
C--67263673(+) TGCCAA/CCCATT 1 -- ut310--------
rs2013751011,2
--67263815(+) CATCTA/GTCCAC 2 Q * stg10--------

HapMap Linkage Disequilibrium report for INSL5 (67263424 - 67266942 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for INSL5:    About this table     
Variant IDTypeSubtypePubMed ID
nsv830093CNV Gain17160897

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 606413    OMIM disorders: --

2 diseases for INSL5:    About MalaCards
cryptorchidism    

1 disease from the University of Copenhagen DISEASES database for INSL5:
Cryptorchidism

INSL5 for disorders           About GeneDecksing

Genetic Association Database (GAD): INSL5
Human Genome Epidemiology (HuGE) Navigator: INSL5 (1 document)

Export disorders for INSL5 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for INSL5 gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with INSL5)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of INSL5, a new member of the insulin superfamily. (PubMed id 10458910)1, 2, 3, 9 Conklin D.... Jaspers S. (1999)
  2. INSL5 is a high affinity specific agonist for GPCR142 (GPR100). (PubMed id 15525639)1, 2, 9 Liu C....Lovenberg T.W. (2005)
  3. Structure of human insulin-like peptide 5 and characterization of conserved hydrogen bonds and electrostatic interactions within the relaxin framework. (PubMed id 19178384)1, 2, 9 Haugaard-JAPnsson L.M....Rosengren K.J. (2009)
  4. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (2010)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  6. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
  7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
  8. Synthesis, conformation, and activity of human insulin-like peptide 5 (INSL5). (PubMed id 18576448)2, 9 Akhter Hossain M....Wade J.D. (2008)
  9. INSL5 may be a unique marker of colorectal endocrine c ells and neuroendocrine tumors. (PubMed id 23438439)1 Mashima H....Ohnishi H. (2013)
  10. Dissociation of heterotrimeric g proteins in cells. (PubMed id 18577758)1 Lambert N.A. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 10022 HGNC: 6088 AceView: INSL5 Ensembl:ENSG00000172410 euGenes: HUgn10022
ECgene: INSL5 H-InvDB: INSL5

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for INSL5 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for INSL5 gene:
Search GeneIP for patents involving INSL5

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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 Proteins for INSL5
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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(GIFtS: 73)
transforming growth factor, beta 1
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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