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Aliases for INSL5 Gene

Aliases for INSL5 Gene

  • Insulin Like 5 2 3 5
  • Insulin-Like Peptide 5 3 4
  • Insulin-Like 5 2 3
  • Prepro-INSL5 2 3
  • PRO182 3
  • UNQ156 3

External Ids for INSL5 Gene

Previous GeneCards Identifiers for INSL5 Gene

  • GC01M067223
  • GC01M066194
  • GC01M066621
  • GC01M066633
  • GC01M066975
  • GC01M065371

Summaries for INSL5 Gene

Entrez Gene Summary for INSL5 Gene

  • The protein encoded by this gene contains a classical signature of the insulin superfamily and is highly similar to relaxin 3 (RLN3/INSL7). [provided by RefSeq, Jul 2008]

GeneCards Summary for INSL5 Gene

INSL5 (Insulin Like 5) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. GO annotations related to this gene include hormone activity.

UniProtKB/Swiss-Prot for INSL5 Gene

  • May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor.

Gene Wiki entry for INSL5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INSL5 Gene

Genomics for INSL5 Gene

Regulatory Elements for INSL5 Gene

Enhancers for INSL5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around INSL5 on UCSC Golden Path with GeneCards custom track

Genomic Location for INSL5 Gene

66,797,741 bp from pter
66,801,259 bp from pter
3,519 bases
Minus strand

Genomic View for INSL5 Gene

Genes around INSL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INSL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INSL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INSL5 Gene

Proteins for INSL5 Gene

  • Protein details for INSL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Insulin-like peptide INSL5
    Protein Accession:
    Secondary Accessions:
    • Q3MIY4
    • Q5VYD8

    Protein attributes for INSL5 Gene

    135 amino acids
    Molecular mass:
    15333 Da
    Quaternary structure:
    • Heterodimer of a B chain and an A chain linked by two disulfide bonds.

    Three dimensional structures from OCA and Proteopedia for INSL5 Gene

neXtProt entry for INSL5 Gene

Proteomics data for INSL5 Gene at MOPED

Post-translational modifications for INSL5 Gene

No Post-translational modifications

Other Protein References for INSL5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for INSL5

No data available for DME Specific Peptides for INSL5 Gene

Domains & Families for INSL5 Gene

Gene Families for INSL5 Gene

Protein Domains for INSL5 Gene


Suggested Antigen Peptide Sequences for INSL5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the insulin family.
  • Belongs to the insulin family.
genes like me logo Genes that share domains with INSL5: view

Function for INSL5 Gene

Molecular function for INSL5 Gene

GENATLAS Biochemistry:
insulin-like 5,expressed in rectal,colon and uterine tissue
UniProtKB/Swiss-Prot Function:
May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor.
genes like me logo Genes that share phenotypes with INSL5: view

Animal Models for INSL5 Gene

MGI Knock Outs for INSL5:

Animal Model Products

  • Taconic Biosciences Mouse Models for INSL5

miRNA for INSL5 Gene

miRTarBase miRNAs that target INSL5

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for INSL5 Gene

Localization for INSL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for INSL5 Gene


Subcellular locations from

Jensen Localization Image for INSL5 Gene COMPARTMENTS Subcellular localization image for INSL5 gene
Compartment Confidence
extracellular 5
nucleus 1

Gene Ontology (GO) - Cellular Components for INSL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
genes like me logo Genes that share ontologies with INSL5: view

Pathways & Interactions for INSL5 Gene

genes like me logo Genes that share pathways with INSL5: view

Interacting Proteins for INSL5 Gene

Gene Ontology (GO) - Biological Process for INSL5 Gene


No data available for SIGNOR curated interactions for INSL5 Gene

Drugs & Compounds for INSL5 Gene

No Compound Related Data Available

Transcripts for INSL5 Gene

mRNA/cDNA for INSL5 Gene

(1) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for INSL5 Gene

No ASD Table

Relevant External Links for INSL5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for INSL5 Gene

mRNA expression in normal human tissues for INSL5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for INSL5 Gene

This gene is overexpressed in Colon - Sigmoid (x14.6) and Colon - Transverse (x10.7).

Protein differential expression in normal tissues from HIPED for INSL5 Gene

This gene is overexpressed in Rectum (34.7) and Colon (34.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for INSL5 Gene

SOURCE GeneReport for Unigene cluster for INSL5 Gene Hs.251380

mRNA Expression by UniProt/SwissProt for INSL5 Gene

Tissue specificity: Highly expressed in rectum with lower levels in uterus and ascending and descending colon.
genes like me logo Genes that share expression patterns with INSL5: view

Protein tissue co-expression partners for INSL5 Gene

Primer Products

Orthologs for INSL5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for INSL5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia INSL5 35
  • 76.3 (n)
  • 68.15 (a)
INSL5 36
  • 55 (a)
(Mus musculus)
Mammalia Insl5 35
  • 69.14 (n)
  • 57.78 (a)
Insl5 16
Insl5 36
  • 58 (a)
(Pan troglodytes)
Mammalia INSL5 35
  • 99.26 (n)
  • 98.52 (a)
INSL5 36
  • 99 (a)
Species with no ortholog for INSL5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for INSL5 Gene

Gene Tree for INSL5 (if available)
Gene Tree for INSL5 (if available)

Paralogs for INSL5 Gene

No data available for Paralogs for INSL5 Gene

Variants for INSL5 Gene

Sequence variations from dbSNP and Humsavar for INSL5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs549148 - 66,801,073(+) CCTCC(A/T)GATGC reference, missense
rs471830 -- 66,799,725(-) aaaat(G/T)atata intron-variant
rs484287 -- 66,801,676(-) gctgg(G/T)cttga upstream-variant-2KB
rs530538 -- 66,801,664(+) gaggc(A/G)aggag upstream-variant-2KB
rs496668 -- 66,799,383(+) tgata(C/T)gtgga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for INSL5 Gene

Variant ID Type Subtype PubMed ID
nsv830093 CNV Gain 17160897

Variation tolerance for INSL5 Gene

Residual Variation Intolerance Score: 83.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.44; 9.73% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for INSL5 Gene

Disorders for INSL5 Gene

Relevant External Links for INSL5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for INSL5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for INSL5 Gene

Publications for INSL5 Gene

  1. Identification of INSL5, a new member of the insulin superfamily. (PMID: 10458910) Conklin D. … Jaspers S. (Genomics 1999) 2 3 4 23 67
  2. Structure of human insulin-like peptide 5 and characterization of conserved hydrogen bonds and electrostatic interactions within the relaxin framework. (PMID: 19178384) Haugaard-Joensson L.M. … Rosengren K.J. (Biochem. J. 2009) 3 23
  3. INSL5 is a high affinity specific agonist for GPCR142 (GPR100). (PMID: 15525639) Liu C. … Lovenberg T.W. (J. Biol. Chem. 2005) 3 23
  4. Insulin-like peptide 5 is an orexigenic gastrointestinal hormone. (PMID: 25028498) Grosse J. … Gribble F.M. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3
  5. Identification of important residues of insulin-like peptide 5 and its receptor RXFP4 for ligand-receptor interactions. (PMID: 25043977) Wang X.Y. … Guo Z.Y. (Arch. Biochem. Biophys. 2014) 3

Products for INSL5 Gene

Sources for INSL5 Gene