INSL5 Gene
protein-coding GIFtS : 49
GCID: GC01 M067223
insulin-like 5
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Aliasesfor INSL5 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Insulin-Like 5 1 2 Insulin-Like Peptide 52 3 PRO1822 UNQ1562 Insulin-Like Peptide INSL52
Export aliases for INSL5 gene to outside databases Previous GC identifers: GC01M066194 GC01M066621 GC01M066633 GC01M066975 GC01M065371
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Summariesfor INSL5 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for INSL5 : The protein encoded by this gene contains a classical signature of the insulin superfamily and is highly similar to relaxin 3 (RLN3/INSL7). (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: INSL5_HUMAN, Q9Y5Q6 Function : May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with highpotency and appears to be the endogenous ligand for this receptor Gene Wiki entry for INSL5
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Genomic Viewsfor INSL5 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000001.10 NC_018912.1 NT_032977.9 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the INSL5 gene promoter: HOXA9B HOXA9 CUTL1 Cdc5 Meis-1b HNF-1A Nkx6-1 HNF-1 Meis-1 Other transcription factors Search SABiosciences Chromatin IP Primers for INSL5 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INSL5
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1p31.3 Ensembl cytogenetic band: 1p31.3 HGNC cytogenetic band: 1p31.3 INSL5 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01M067223: view genomic region
(about GC identifiers )
Start:
67,263,424 bp from pter
End:
67,266,939 bp from pter
Size:
3,516 bases
Orientation:
minus strand
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Proteinsfor INSL5 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: INSL5_HUMAN, Q9Y5Q6 (See
protein sequence )Recommended Name: Insulin-like peptide INSL5 precursor Size : 135 amino acids; 15333 Da
Subunit : Heterodimer of a B chain and an A chain linked by two disulfide bonds
Subcellular location : Secreted
2 PDB 3D structures from and Proteopedia for INSL5 :2K1V (3D)
  2KBC (3D)
 
Secondary accessions : Q3MIY4 Q5VYD8Explore the universe of human proteins at neXtProt for INSL5: NX_Q9Y5Q6 INSL5 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_005469.2 ENSEMBL proteins: ENSP00000302724 Reactome Protein details: Q9Y5Q6 Human Recombinant Protein Products for INSL5: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005575 cellular_component
ND -- GO:0005576 extracellular region
TAS --
INSL5 for ontologies About GeneDecksing INSL5 Antibody Products: Assay Products for INSL5:
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Protein
Domains / Familiesfor INSL5 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
INSL5 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q9Y5Q6 ProtoNet protein and cluster: Q9Y5Q6
1 Blocks protein family : IPB004825 Insulin/IGF/relaxin UniProtKB/Swiss-Prot: INSL5_HUMAN, Q9Y5Q6 Similarity : Belongs to the insulin family
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Functionfor INSL5 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: INSL5_HUMAN, Q9Y5Q6 Function : May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with highpotency and appears to be the endogenous ligand for this receptor
Genatlas biochemistry entry for INSL5 : insulin-like 5,expressed in rectal,colon and uterine tissue Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005179 hormone activity
NAS --
INSL5 for ontologies About GeneDecksing Phenotypes: 1 GenomeRNAi human phenotype for INSL5 : 5 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Insl5) :
INSL5 for phenotypes About GeneDecksing Animal Models: Mouse knock-outs for INSL5: Insl5 tm1Dgen Insl5 tm1Imad Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for INSL5 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for INSL5OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: INSL5 (NM_005478 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for INSL5 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat INSL5
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INSL5
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Pathways & Interactionsfor INSL5 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Class A/1 (Rhodopsin-like receptors) 2 Signaling by GPCR 3 Relaxin receptors
Pathway sources See GeneCards unified pathways Show all pathways 5/8
Reactome Pathways for INSL5 (see all 8 )
INSL5 for pathways About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for INSL5 Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0008150 biological_process
ND --
INSL5 for ontologies About GeneDecksing
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Drugs & Compoundsfor INSL5 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for INSL5 Search CenterWatch for drugs/clinical trials and news about INSL5
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Transcriptsfor INSL5 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for INSL5 gene: NM_005478.4 Unigene Cluster for INSL5:
Insulin-like 5 Hs.251380 Unigene Representative Sequence: AF133816 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000304526 (uc001dcw.3 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for INSL5 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for INSL5OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: INSL5 (NM_005478 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for INSL5 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat INSL5
Additional cDNA sequence: AF133816.2 AY359030.1 BC101646.1 BC101648.1
1 DOTS entry : DT.91750530
3 AceView cDNA sequences :
NM_005478 AY359030 AF133816 GeneLoc Exon Structure
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Expression for INSL5 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section INSL5 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TTTAATTACAAbout this image INSL5 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Eye Outer Nuclear Layer Mature Rod Cells Photoreceptors, Retina Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See INSL5 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for INSL5 SOURCE GeneReport for Unigene cluster: Hs.251380 UniProtKB/Swiss-Prot: INSL5_HUMAN, Q9Y5Q6 Tissue specificity : Highly expressed in rectum with lower levels in uterus and ascending and descending colon SABiosciences Custom PCR Arrays for INSL5 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for INSL5Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat INSL5 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat INSL5 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat INSL5 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INSL5
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Orthologsfor INSL5 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of human and mouse.
Orthologs for INSL5 gene from 1/3 species (see all 3 ) About this table
ENSEMBL Gene Tree for INSL5 (if available)TreeFam Gene Tree for INSL5 (if available)
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Paralogsfor INSL5 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor INSL5 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 1 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for INSL5 (67263424 - 67266939 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for INSL5: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing INSL5
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Disorders
/ Diseasesfor INSL5 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
INSL5 for disorders About GeneDecksing
OMIM gene information: 606413
OMIM disorders : --1 disease for INSL5 : About MalaCards cryptorchidism Human Genome Epidemiology (HuGE) Navigator: INSL5 (1 document)Export disorders for INSL5 gene to outside databases
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Publicationsfor INSL5 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for INSL5 gene, integrated from 9 sources (see all 24 ): (articles sorted by number of sources associating them with INSL5) Utopia : connect your pdf to the dynamic world of online information
Identification of INSL5, a new member of the insulin superfamily. (PubMed id 10458910) 1 , 2 , 3, 9 Conklin D.... Jaspers S. (1999) INSL5 is a high affinity specific agonist for GPCR142 (GPR100). (PubMed id 15525639) 1 , 2 , 9 Liu C....Lovenberg T.W. (2005) Structure of human insulin-like peptide 5 and characterization of conserved hydrogen bonds and electrostatic interactions within the relaxin framework. (PubMed id 19178384) 1 , 2 , 9 Haugaard-JAPnsson L.M....Rosengren K.J. (2009) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161) 1 , 2 Zhang Z. and Henzel W.J. (2004) The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309) 1 , 2 Clark H.F.... Gray A.M. (2003) Synthesis, conformation, and activity of human insulin-like peptide 5 (INSL5). (PubMed id 18576448) 2 , 9 Akhter Hossain M....Wade J.D. (2008) Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603) 1 Flachsbart F....Nebel A. (2010) Dissociation of heterotrimeric g proteins in cells. (PubMed id 18577758) 1 Lambert N.A. (2008) The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 2 Gregory S.G.... Bentley D.R. (2006)
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External Searches for INSL5 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing INSL5 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing INSL5 gene
(According to HUGE )
About This Section --
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Specialized Databases showing INSL5 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for INSL5 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for INSL5 gene: Search GeneIP for patents involving INSL5 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor INSL5 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for INSL5 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for INSL5 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for INSL5 OriGene Protein Over-expression Lysate for INSL5 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for INSL5 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for INSL5 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for INSL5 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for INSL5 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for INSL5 OriGene Custom Protein Services for INSL5 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat INSL5 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing INSL5 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INSL5 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat INSL5 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat INSL5 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat INSL5
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INSL5
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat INSL5
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