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Aliases for INSL5 Gene

Aliases for INSL5 Gene

  • Insulin Like 5 2 3 5
  • Insulin-Like Peptide 5 3 4
  • Prepro-INSL5 2 3
  • Insulin-Like Peptide INSL5 3
  • Insulin-Like 5 2
  • PRO182 3
  • UNQ156 3

External Ids for INSL5 Gene

Previous GeneCards Identifiers for INSL5 Gene

  • GC01M067223
  • GC01M066194
  • GC01M066621
  • GC01M066633
  • GC01M066975
  • GC01M065371

Summaries for INSL5 Gene

Entrez Gene Summary for INSL5 Gene

  • The protein encoded by this gene contains a classical signature of the insulin superfamily and is highly similar to relaxin 3 (RLN3/INSL7). [provided by RefSeq, Jul 2008]

GeneCards Summary for INSL5 Gene

INSL5 (Insulin Like 5) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Relaxin signaling pathway. Gene Ontology (GO) annotations related to this gene include hormone activity.

UniProtKB/Swiss-Prot for INSL5 Gene

  • May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor.

Gene Wiki entry for INSL5 Gene

Additional gene information for INSL5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INSL5 Gene

Genomics for INSL5 Gene

GeneHancer (GH) Regulatory Elements for INSL5 Gene

Promoters and enhancers for INSL5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I066801 Promoter 0.5 EPDnew 550.8 0.0 -37 0.1 INSL5 ENSG00000231080
GH01I067194 Enhancer 1 FANTOM5 ENCODE 1.3 -393.6 -393638 1.5 HDGF PKNOX1 SMAD1 BACH1 EBF1 BMI1 NFATC1 ATF7 IKZF2 RUNX3 RNU6-586P C1orf141 IL23R SLC35D1 WDR78 IL12RB2 MIER1 INSL5 GC01M067171
GH01I066757 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 0.3 +42.9 42925 1.8 PKNOX1 ATF1 ARNT IRF4 TCF12 GATA2 ATF7 RUNX3 NCOA1 REST TCTEX1D1 SGIP1 MIER1 INSL5
GH01I066777 Enhancer 0.8 dbSUPER 0.3 +22.5 22473 3 PKNOX1 ZSCAN4 INSM2 ZNF76 FEZF1 ZNF335 ZNF213 ZNF366 ZSCAN5C ZNF391 TCTEX1D1 SGIP1 INSL5
GH01I066764 Enhancer 0.6 dbSUPER 0.3 +36.3 36314 1 CTCF ZNF654 ZNF362 TRIM22 MNT REST RAD21 ZNF664 FOXK2 ARID2 TCTEX1D1 INSL5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around INSL5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the INSL5 gene promoter:

Genomic Locations for INSL5 Gene

Genomic Locations for INSL5 Gene
chr1:66,797,741-66,801,259
(GRCh38/hg38)
Size:
3,519 bases
Orientation:
Minus strand
chr1:67,263,424-67,266,942
(GRCh37/hg19)

Genomic View for INSL5 Gene

Genes around INSL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INSL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INSL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INSL5 Gene

Proteins for INSL5 Gene

  • Protein details for INSL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5Q6-INSL5_HUMAN
    Recommended name:
    Insulin-like peptide INSL5
    Protein Accession:
    Q9Y5Q6
    Secondary Accessions:
    • Q3MIY4
    • Q5VYD8

    Protein attributes for INSL5 Gene

    Size:
    135 amino acids
    Molecular mass:
    15333 Da
    Quaternary structure:
    • Heterodimer of a B chain and an A chain linked by two disulfide bonds.

    Three dimensional structures from OCA and Proteopedia for INSL5 Gene

neXtProt entry for INSL5 Gene

Post-translational modifications for INSL5 Gene

No Post-translational modifications

Other Protein References for INSL5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for INSL5 Gene

Domains & Families for INSL5 Gene

Gene Families for INSL5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for INSL5 Gene

Suggested Antigen Peptide Sequences for INSL5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y5Q6

UniProtKB/Swiss-Prot:

INSL5_HUMAN :
  • Belongs to the insulin family.
Family:
  • Belongs to the insulin family.
genes like me logo Genes that share domains with INSL5: view

Function for INSL5 Gene

Molecular function for INSL5 Gene

GENATLAS Biochemistry:
insulin-like 5,expressed in rectal,colon and uterine tissue
UniProtKB/Swiss-Prot Function:
May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor.

Gene Ontology (GO) - Molecular Function for INSL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IBA --
GO:0005179 hormone activity IBA --
genes like me logo Genes that share ontologies with INSL5: view
genes like me logo Genes that share phenotypes with INSL5: view

Animal Models for INSL5 Gene

MGI Knock Outs for INSL5:

miRNA for INSL5 Gene

miRTarBase miRNAs that target INSL5

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for INSL5 Gene

Localization for INSL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for INSL5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for INSL5 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for INSL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IBA,TAS --
genes like me logo Genes that share ontologies with INSL5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for INSL5 Gene

Pathways & Interactions for INSL5 Gene

genes like me logo Genes that share pathways with INSL5: view

Interacting Proteins for INSL5 Gene

Gene Ontology (GO) - Biological Process for INSL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0008150 biological_process ND --
GO:0010469 regulation of receptor activity IEA --
GO:2000253 positive regulation of feeding behavior IBA --
genes like me logo Genes that share ontologies with INSL5: view

No data available for SIGNOR curated interactions for INSL5 Gene

Drugs & Compounds for INSL5 Gene

No Compound Related Data Available

Transcripts for INSL5 Gene

mRNA/cDNA for INSL5 Gene

(1) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for INSL5 Gene

No ASD Table

Relevant External Links for INSL5 Gene

GeneLoc Exon Structure for
INSL5
ECgene alternative splicing isoforms for
INSL5

Expression for INSL5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for INSL5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for INSL5 Gene

This gene is overexpressed in Colon - Sigmoid (x14.6) and Colon - Transverse (x10.7).

Protein differential expression in normal tissues from HIPED for INSL5 Gene

This gene is overexpressed in Rectum (34.7) and Colon (34.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for INSL5 Gene



Protein tissue co-expression partners for INSL5 Gene

NURSA nuclear receptor signaling pathways regulating expression of INSL5 Gene:

INSL5

SOURCE GeneReport for Unigene cluster for INSL5 Gene:

Hs.251380

mRNA Expression by UniProt/SwissProt for INSL5 Gene:

Q9Y5Q6-INSL5_HUMAN
Tissue specificity: Highly expressed in rectum with lower levels in uterus and ascending and descending colon.

Evidence on tissue expression from TISSUES for INSL5 Gene

  • Intestine(4.5)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with INSL5: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for INSL5 Gene

Orthologs for INSL5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for INSL5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INSL5 33 34
  • 99.26 (n)
cow
(Bos Taurus)
Mammalia INSL5 33 34
  • 76.3 (n)
mouse
(Mus musculus)
Mammalia Insl5 33 16 34
  • 69.14 (n)
Species where no ortholog for INSL5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for INSL5 Gene

ENSEMBL:
Gene Tree for INSL5 (if available)
TreeFam:
Gene Tree for INSL5 (if available)

Paralogs for INSL5 Gene

No data available for Paralogs for INSL5 Gene

Variants for INSL5 Gene

Sequence variations from dbSNP and Humsavar for INSL5 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000508800 -- 66,801,013(-) A/C intron_variant
rs1001043163 -- 66,802,091(-) T/A upstream_transcript_variant
rs1001202243 -- 66,800,186(-) C/T intron_variant
rs1001254372 -- 66,800,469(-) G/T intron_variant
rs1002880552 -- 66,798,818(-) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for INSL5 Gene

Variant ID Type Subtype PubMed ID
esv3893623 CNV gain 25118596
nsv830093 CNV gain 17160897

Variation tolerance for INSL5 Gene

Residual Variation Intolerance Score: 83.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.44; 9.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for INSL5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
INSL5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INSL5 Gene

Disorders for INSL5 Gene

Additional Disease Information for INSL5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for INSL5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for INSL5 Gene

Publications for INSL5 Gene

  1. Identification of INSL5, a new member of the insulin superfamily. (PMID: 10458910) Conklin D … Jaspers S (Genomics 1999) 2 3 4 22 58
  2. Structure of human insulin-like peptide 5 and characterization of conserved hydrogen bonds and electrostatic interactions within the relaxin framework. (PMID: 19178384) Haugaard-Jönsson LM … Rosengren KJ (The Biochemical journal 2009) 3 4 22 58
  3. INSL5 is a high affinity specific agonist for GPCR142 (GPR100). (PMID: 15525639) Liu C … Lovenberg TW (The Journal of biological chemistry 2005) 3 4 22 58
  4. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 44 58
  5. Synthesis, conformation, and activity of human insulin-like peptide 5 (INSL5). (PMID: 18576448) Akhter Hossain M … Wade JD (Chembiochem : a European journal of chemical biology 2008) 4 22 58

Products for INSL5 Gene

Sources for INSL5 Gene

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