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Aliases for INSL4 Gene

Aliases for INSL4 Gene

  • Insulin Like 4 2 3 5
  • Insulin-Like 4 (Placenta) 2 3
  • Insulin-Like Peptide 4 3 4
  • EPIL 3 4
  • Early Placenta Insulin-Like Peptide (EPIL) 3

External Ids for INSL4 Gene

Previous GeneCards Identifiers for INSL4 Gene

  • GC09P005385
  • GC09P005212
  • GC09P005221
  • GC09P005266

Summaries for INSL4 Gene

Entrez Gene Summary for INSL4 Gene

  • INSL4 encodes the insulin-like 4 protein, a member of the insulin superfamily. INSL4 encodes a precursor that undergoes post-translational cleavage to produce 3 polypeptide chains, A-C, that form tertiary structures composed of either all three chains, or just the A and B chains. Expression of INSL4 products occurs within the early placental cytotrophoblast and syncytiotrophoblast. [provided by RefSeq, Jul 2008]

GeneCards Summary for INSL4 Gene

INSL4 (Insulin Like 4) is a Protein Coding gene. GO annotations related to this gene include receptor binding and insulin-like growth factor receptor binding.

UniProtKB/Swiss-Prot for INSL4 Gene

  • May play an important role in trophoblast development and in the regulation of bone formation.

Gene Wiki entry for INSL4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INSL4 Gene

Genomics for INSL4 Gene

Regulatory Elements for INSL4 Gene

Enhancers for INSL4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around INSL4 on UCSC Golden Path with GeneCards custom track

Promoters for INSL4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around INSL4 on UCSC Golden Path with GeneCards custom track

Genomic Location for INSL4 Gene

5,231,419 bp from pter
5,235,304 bp from pter
3,886 bases
Plus strand

Genomic View for INSL4 Gene

Genes around INSL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INSL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INSL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INSL4 Gene

Proteins for INSL4 Gene

  • Protein details for INSL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Early placenta insulin-like peptide
    Protein Accession:
    Secondary Accessions:
    • A8K678
    • Q5W127

    Protein attributes for INSL4 Gene

    139 amino acids
    Molecular mass:
    15445 Da
    Quaternary structure:
    No Data Available

neXtProt entry for INSL4 Gene

Proteomics data for INSL4 Gene at MOPED

Post-translational modifications for INSL4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for INSL4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for INSL4 Gene

Domains & Families for INSL4 Gene

Protein Domains for INSL4 Gene


Suggested Antigen Peptide Sequences for INSL4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the insulin family.
  • Belongs to the insulin family.
genes like me logo Genes that share domains with INSL4: view

No data available for Gene Families for INSL4 Gene

Function for INSL4 Gene

Molecular function for INSL4 Gene

GENATLAS Biochemistry:
insulin-like 4,growth factor expressed in placenta and uterus
UniProtKB/Swiss-Prot Function:
May play an important role in trophoblast development and in the regulation of bone formation.
genes like me logo Genes that share phenotypes with INSL4: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for INSL4 Gene

Localization for INSL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for INSL4 Gene


Subcellular locations from

Jensen Localization Image for INSL4 Gene COMPARTMENTS Subcellular localization image for INSL4 gene
Compartment Confidence
extracellular 5

No data available for Gene Ontology (GO) - Cellular Components for INSL4 Gene

Pathways & Interactions for INSL4 Gene

SuperPathways for INSL4 Gene

No Data Available

Interacting Proteins for INSL4 Gene

Gene Ontology (GO) - Biological Process for INSL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development TAS 8702754
GO:0007565 female pregnancy TAS 8702754
GO:0008283 cell proliferation TAS 8702754
genes like me logo Genes that share ontologies with INSL4: view

No data available for Pathways by source and SIGNOR curated interactions for INSL4 Gene

Drugs & Compounds for INSL4 Gene

(1) Drugs for INSL4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with INSL4: view

Transcripts for INSL4 Gene

mRNA/cDNA for INSL4 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(47) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for INSL4 Gene

Insulin-like 4 (placenta):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for INSL4 Gene

No ASD Table

Relevant External Links for INSL4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for INSL4 Gene

mRNA expression in normal human tissues for INSL4 Gene

SOURCE GeneReport for Unigene cluster for INSL4 Gene Hs.418506

mRNA Expression by UniProt/SwissProt for INSL4 Gene

Tissue specificity: Expressed in placenta, uterus and in fetal perichondrium. Expression levels were increased in both early placentas and molar pregnancies and were reduced in choriocarcinoma cells.
genes like me logo Genes that share expression patterns with INSL4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for INSL4 Gene

Orthologs for INSL4 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for INSL4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia INSL4 35
  • 98.56 (n)
  • 97.84 (a)
INSL4 36
  • 98 (a)
Species with no ortholog for INSL4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for INSL4 Gene

Gene Tree for INSL4 (if available)
Gene Tree for INSL4 (if available)

Paralogs for INSL4 Gene Pseudogenes for INSL4 Gene

genes like me logo Genes that share paralogs with INSL4: view

No data available for Paralogs for INSL4 Gene

Variants for INSL4 Gene

Sequence variations from dbSNP and Humsavar for INSL4 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1128593 -- 5,234,202(+) taccc(C/T)gattt downstream-variant-500B
rs7852875 -- 5,231,583(+) CTCCT(C/G/T)AGAGA reference, synonymous-codon
rs1555476 -- 5,233,054(+) ATTTC(C/T)ATTTA intron-variant
rs1803824 -- 5,231,511(+) GGAGA(G/T)TTCAG utr-variant-5-prime
rs113543827 -- 5,230,933(+) CCTTG(A/G)TGTCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for INSL4 Gene

Variant ID Type Subtype PubMed ID
nsv892136 CNV Gain 21882294
nsv527495 CNV Gain 19592680
nsv466100 CNV Gain 19166990
dgv8017n71 CNV Loss 21882294
nsv892141 CNV Gain 21882294
nsv831495 CNV Loss 17160897
nsv525777 CNV Loss 19592680
nsv892144 CNV Gain 21882294
nsv892145 CNV Gain 21882294

Variation tolerance for INSL4 Gene

Residual Variation Intolerance Score: 78.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.43; 28.01% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for INSL4 Gene

Disorders for INSL4 Gene

Relevant External Links for INSL4

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for INSL4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for INSL4 Gene

Publications for INSL4 Gene

  1. Cloning of a new member of the insulin gene superfamily (INSL4) expressed in human placenta. (PMID: 8666396) Chassin D. … Bellet D. (Genomics 1995) 2 3 4 23 67
  2. The INSL4 gene maps close to WI-5527 at 9p24.1-->p23.3 clustered with two relaxin genes and outside the critical region for the monosomy 9p syndrome. (PMID: 9730618) Veitia R. … McElreavey K. (Cytogenet. Cell Genet. 1998) 2 3 23
  3. Early placental insulin-like protein (INSL4 or EPIL) in placental and fetal membrane growth. (PMID: 15958731) Millar L. … Bryant-Greenwood G. (Biol. Reprod. 2005) 3 23
  4. [Expression of early placenta insulin-like growth factor (EPIL) in breast cancer cells provides an autocrine loop with enhancement of predominantly HER-2-related invasivity]. (PMID: 18035692) BA1rger H. … Brandt B. (Verh Dtsch Ges Pathol 2005) 3 23
  5. Placenta-specific INSL4 expression is mediated by a human endogenous retrovirus element. (PMID: 12606452) BiA"che I. … Vidaud M. (Biol. Reprod. 2003) 3 23

Products for INSL4 Gene

Sources for INSL4 Gene