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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

INSL3 Gene

protein-coding   GIFtS: 55
GCID: GC19M017928

insulin-like 3 (Leydig cell)

(Previous name: relaxin-like factor )
(Previous symbol: RLNL)
 Explore 31 diseases affiliated with
INSL3 via our new
 Human Malady Compendium 
Biological research products
for INSL3
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Insulin-Like 3 (Leydig Cell)1 2     MGC1198191
RLF1 2 3     Insulin-Like 32
RLNL1 2 3     Ley-I-L3
Relaxin-Like Factor1 3     Leydig Insulin -Like Hormone2
Leydig Insulin-Like Peptide2 3     Relaxin-Like Factor B2
MGC1198181     Ley-I-L3

External Ids:    HGNC: 60861   Entrez Gene: 36402   Ensembl: ENSG000002480997   OMIM: 1467385   UniProtKB: P514603   

Export aliases for INSL3 gene to outside databases

Previous GC identifers: GC19M018421 GC19M018319 GC19M017772 GC19M017788 GC19M017492


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for INSL3:
This gene encodes a member of the insulin-like hormone superfamily. The encoded protein is mainly produced in gonadal
tissues. Studies of the mouse counterpart suggest that this gene may be involved in the development of urogenital
tract and female fertility. This protein may also act as a hormone to regulate growth and differentiation of
gubernaculum, and thus mediating intra-abdominal testicular descent. Mutations in this gene may lead to
cryptorchidism. Alternate splicing results in multiple transcript variants. (provided by RefSeq, May 2012)

UniProtKB/Swiss-Prot: INSL3_HUMAN, P51460
Function: Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in
fetal life. Is a ligand for LGR8 receptor

Gene Wiki entry for INSL3


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the INSL3 gene promoter:
         c-Fos   STAT5B   RP58   AP-1   JunB   Fra-1   FosB   HNF-4alpha2   HNF-4alpha1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidINSL3 promoter sequence
   Search SABiosciences Chromatin IP Primers for INSL3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INSL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2-p12   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.2-p12

INSL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INSL3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M017928:  view genomic region     (about GC identifiers)

Start:
17,927,322 bp from pter      End:
17,932,383 bp from pter
Size:
5,062 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: INSL3_HUMAN, P51460 (See protein sequence)
Recommended Name: Insulin-like 3 precursor  
Size: 131 amino acids; 14502 Da
Subunit: Heterodimer of a B chain and an A chain linked by two disulfide bonds
Subcellular location: Secreted
Sequence caution: Sequence=CAA52017.1; Type=Erroneous gene model prediction;
3 PDB 3D structures from and Proteopedia for INSL3:
2H8B (3D)        2K6T (3D)        2K6U (3D)    
Secondary accessions: B4DZ72 G3XAG0 Q3KPI5 Q3KPI6 Q6YNB5 Q9UEA2 Q9UPH6
Alternative splicing: 2 isoforms:  P51460-1   P51460-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for INSL3: NX_P51460

INSL3 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins (2 alternative transcripts): 
NP_001252516.1  NP_005534.2  

ENSEMBL proteins: 
 ENSP00000321724   ENSP00000369017  
Reactome Protein details: P51460
Human Recombinant Protein Products: 
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OriGene Protein Over-expression Lysate: INSL3
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Novus Biologicals INSL3 Lysate
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Uscn Proteins for INSL3

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005615extracellular space IEA--
GO:0005625soluble fraction ----
GO:0048471perinuclear region of cytoplasm IEA--


INSL3 for ontologies           About GeneDecksing



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Uscn ELISAs and CLIAs for INSL3


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

INSL3 for domains           About GeneDecksing

2 InterPro domains/families:
 IPR016179 Insulin-like
 IPR022353 Insulin_CS

Graphical View of Domain Structure for InterPro Entry P51460

ProtoNet protein and cluster: P51460

1 Blocks protein family: IPB004825 Insulin/IGF/relaxin

UniProtKB/Swiss-Prot: INSL3_HUMAN, P51460
Similarity: Belongs to the insulin family


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

     UniProtKB/Swiss-Prot: INSL3_HUMAN, P51460
Function: Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in
fetal life. Is a ligand for LGR8 receptor

     Genatlas biochemistry entry for INSL3:
Leydig insulin-like protein 3,member of the insulin-like superfamily

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat INSL3
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SwitchGear 3'UTR luciferase reporter plasmidINSL3 3' UTR sequence
Inhib. RNA
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INSL3

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001664G-protein coupled receptor binding IEA--
GO:0002020protease binding IPI--
GO:0005102receptor binding TAS8020942
GO:0005158insulin receptor binding TAS8253799
GO:0005179hormone activity IEA--


INSL3 for ontologies           About GeneDecksing


Animal Models:
     Mouse knock-out Insl3tm1Imad for INSL3
     4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Insl3):
 behavior/neurological  endocrine/exocrine gland  reproductive system  skeleton 

INSL3 for phenotypes           About GeneDecksing


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways  About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Class A/1 (Rhodopsin-like receptors)
Class A/1 (Rhodopsin-like receptors)1.00
Peptide ligand-binding receptors0.61
GPCR ligand binding0.75
2Signaling by GPCR
Signaling by GPCR1.00
Signal Transduction0.56
GPCR downstream signaling0.89
3Relaxin receptors
Relaxin receptors1.00
4G beta:gamma signalling through PLC beta
G alpha (s) signalling events0.14

Pathway sources
See GeneCards unified pathways
Show all pathways


5/8        Reactome Pathways for INSL3 (see all 8)
    GPCR downstream signaling
Peptide ligand-binding receptors
Signaling by GPCR
GPCR ligand binding
Class A/1 (Rhodopsin-like receptors)



INSL3 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for INSL3

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for INSL3 (P514603 ENSP000003217244) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
RXFP2Q8WXD03, ENSP000002983864I2D: score=2 STRING: ENSP00000298386
INSRENSP000003038304STRING: ENSP00000303830
CCNB1IP1ENSP000003373964STRING: ENSP00000337396
About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001556oocyte maturation IEA--
GO:0001701in utero embryonic development IEA--
GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA--
GO:0007267cell-cell signaling TAS8253799
GO:0007283spermatogenesis TAS8253799


INSL3 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

INSL3 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for INSL3
10/12 Novoseek chemical compound relationships for INSL3 gene (see all 12)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
phthalate esters 65.1 1 18949836 (1)
testosterone 64.6 72 18499751 (6), 16804040 (4), 19226271 (4), 19416189 (3) (see all 28)
phthalate 46.4 1 17258888 (1)
3beta-hydroxysteroid 26.7 2 9239733 (1), 10519633 (1)
diethylstilbestrol 21.4 2 12684664 (1)
alanine 16.8 1 11380919 (1)
threonine 9.93 1 11380919 (1)
valine 2.93 1 12464361 (1)
lysine 0 1 15209497 (1)
steroid 0 1 14687758 (1)

Search CenterWatch for drugs/clinical trials and news about INSL3 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for INSL3 gene (2 alternative transcripts): 
NM_001265587.1  NM_005543.3  

Unigene Cluster for INSL3:

Insulin-like 3 (Leydig cell)
Hs.37062  [show with all ESTs]
Unigene Representative Sequence: BM560108
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000317306(uc002nhm.1) ENST00000379695(uc010ebf.1)

miRNA
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Inhib. RNA
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Clone
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INSL3
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INSL3

Additional cDNA sequence: 

AK302780.1 AY082014.1 BC032810.1 BC040435.1 BC053345.1 BC061886.1 BC071706.1 BC106721.1 
BC106722.1 BC107045.2 S72482.1 

4 DOTS entries:

DT.105201  DT.97798826  DT.91751496  DT.95082839 

24/48 AceView cDNA sequences (see all 48):

BI829405 NM_005543 U31602 BC040435 CR608936 BC053345 BX386607 BI831421 
BI825465 BC061886 BI828132 S72482 BI826252 BI828546 AI825066 BI520239 
BM560108 BI828079 BI825332 BI831038 BC032810 BI826480 BG718760 BC071706 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

INSL3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTAACACCC

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)

About this image
See INSL3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for INSL3

SOURCE GeneReport for Unigene cluster: Hs.37062

UniProtKB/Swiss-Prot: INSL3_HUMAN, P51460
Tissue specificity: Expressed in prenatal and postnatal Leydig cells. Found as well in the corpus luteum, trophoblast,
fetal membranes and breast

    SABiosciences Expression via Pathway-Focused PCR Array including INSL3: 
          Insulin Signaling Pathway in human mouse rat

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INSL3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for INSL3 gene from 1/6 species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Insl31 , 5 insulin-like 31, 5 68.64(n)1
61.02(a)1
  8 (34.43 cM)5
163361  NM_013564.71  NP_038592.31 
 716892145 


ENSEMBL Gene Tree for INSL3 (if available)
TreeFam Gene Tree for INSL3 (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/177 NCBI SNPs in INSL3 are shown (see all 177    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1219125561,2
Cpathogenic17493188(-) TCACCA/GCCACC 4 T A H R mis10--------
rs1048946981,2
Cpathogenic17493189(-) ATCACC/TGCCAC 4 T R C syn1 mis10--------
rs746306511,2
--17492643(+) CAATGC/TCTCTC 2 -- ds50012Minor allele frequency- T:0.04CSA WA 120
rs601332821,2
F,--17492674(+) GTGCCG/CGTGGG 2 -- ds50011Minor allele frequency- C:0.05WA 118
rs1135446461,2
C--17492753(+) GCAGGT/AAGCTG 2 -- ds50011Minor allele frequency- A:0.00CSA 1
rs1167728341,2
C,F,--17492816(+) GGGAGC/TGGAGC 2 -- ut311Minor allele frequency- T:0.03WA 118
rs177506421,2
C,F,H,--17492996(+) CAAAGG/TCCTGT 2 -- ut3120Minor allele frequency- T:0.02NA NS EA 1936
rs754171991,2
C,--17493191(+) GGCGGG/TGATGG 4 T P H mis10--------
rs1048946971,2
C,--17493215(-) GCAGCC/TCCTGC 4 P S L mis12Minor allele frequency- T:0.00NA 4726
rs1114838121,2
C--17493303(+) CTCACG/CTGGGG 2 -- spa11Minor allele frequency- C:0.00CSA 1

HapMap Linkage Disequilibrium report for INSL3 (17927322 - 17932383 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for INSL3
     1 CNV: 5091
Human Gene Mutation Database (HGMD): INSL3

SABiosciences Cancer Mutation PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

INSL3 for disorders           About GeneDecksing

OMIM gene information: 146738   
OMIM disorders: 219050  
UniProtKB/Swiss-Prot: INSL3_HUMAN, P51460
  • Defects in INSL3 seems to be a cause of cryptorchidism (CRYPTO) [MIM:219050]; also known as impaired
  • testicular descent. It is one of the most frequent congenital abnormalities in humans, involving 2-5% of male births.
    Cryptorchidism is associated with increased risk of infertility and testicular cancer. The frequency of INSL3 gene
    mutations as a cause of cryptorchidism is low

    20/31 diseases for INSL3 (see all 31):    About MalaCards
    cryptorchidism    sertoli-leydig cell tumor    cryptorchidism, idiopathic    leydig cell tumor
    type 2 diabetes mellitus    severe combined immunodeficiency    anorchia    combined immunodeficiency
    polycystic ovary syndrome    testicular neoplasm    hyperandrogenism    diabetes mellitus
    male infertility    testicular disease    goiter    testicular cancer
    klinefelter's syndrome    azoospermia    infertility    hypospadias

    5 diseases from the University of Copenhagen DISEASES database for INSL3:
    Cryptorchidism     Testicular cancer     Infertility     Hypospadias
    Male infertility

    10/15 Novoseek disease relationships for INSL3 gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cryptorchidism 90.4 84 11992081 (5), 15533513 (4), 11383919 (4), 11380919 (4) (see all 39)
    testicular dysgenesis 84.1 3 16687567 (1), 19329805 (1)
    testicular cancer 66.5 4 16687567 (2), 15755855 (1)
    testicular diseases 59.8 1 15755855 (1)
    azoospermia 43.9 2 17314233 (2)
    infertility 42.6 5 16687567 (2), 15956751 (1), 15579743 (1)
    thyroid carcinoma 30.5 9 12684664 (3), 19416220 (1), 16010410 (1), 19950223 (1)
    hyperandrogenism 25.5 4 16926256 (2), 17356050 (2)
    hyperplasia 7.81 6 10202675 (3), 10065864 (2), 15956746 (1)
    goiter 6.98 1 12684664 (1)

    Genetic Association Database (GAD): INSL3
    Human Genome Epidemiology (HuGE) Navigator: INSL3 (19 documents)

    Export disorders for INSL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for INSL3 gene, integrated from 9 sources (see all 200):
    (articles sorted by number of sources associating them with INSL3)
        Utopia: connect your pdf to the dynamic
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    1. Ala/Thr60 variant of the Leydig insulin-like hormone is not associated with cryptorchidism in the Japanese population. (PubMed id 11380919)1, 2, 4, 9 Takahashi I.... Takada G. (2001)
    2. Different insulin-like 3 (INSL3) gene mutations not associated with human cryptorchidism. (PubMed id 11383919)1, 2, 4, 9 Marin P.... Foresta C. (2001)
    3. Insulin-like 3/relaxin-like factor gene mutations are associated with cryptorchidism. (PubMed id 11095425)1, 2, 4, 9 Tomboc M....Witchel S.F. (2000)
    4. Genetic analysis of the INSL3 gene in patients with maldescent of the testis. (PubMed id 11182749)1, 2, 4, 9 Lim H.N....Hughes I.A. (2001)
    5. Structural organization of the porcine and human genes coding for a Leydig cell-specific insulin-like peptide (LEY I-L) and chromosomal localization of the human gene (INSL3). (PubMed id 8020942)1, 2, 3, 9 Burkhardt E....Engel W. (1994)
    6. Solution structure of a conformationally restricted fully active derivative of the human relaxin-like factor. (PubMed id 19086273)1, 2, 9 BA1llesbach E.E....Led J.J. (2008)
    7. A common polymorphism in the human relaxin-like factor (RLF) gene: no relationship with cryptorchidism. (PubMed id 10759163)1, 2, 9 Koskimies P.... Toppari J. (2000)
    8. Solution structure and characterization of the LGR8 receptor binding surface of insulin-like peptide 3. (PubMed id 16867980)1, 2, 9 Rosengren K.J....Wade J.D. (2006)
    9. A novel mutation of the insulin-like 3 gene in patients with cryptorchidism. (PubMed id 12601553)1, 2, 9 Canto P.... Mendez J.P. (2003)
    10. Absence of mutations involving the INSL3 gene in human idiopathic cryptorchidism. (PubMed id 10729310)1, 2, 9 Krausz C.... McElreavey K. (2000)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3640 HGNC: 6086 AceView: INSL3 Ensembl:ENSG00000248099 euGenes: HUgn3640
    ECgene: INSL3 H-InvDB: INSL3

    (According to HUGE)
    About This Section
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    PharmGKB entry for INSL3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for INSL3 gene:
    Search GeneIP for patents involving INSL3

    GeneCards and IP:
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