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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

INSL3 Gene

protein-coding   GIFtS: 55
GCID: GC19M017928

Insulin-Like 3 (Leydig Cell)

(Previous name: relaxin-like factor)
(Previous symbol: RLNL)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Insulin-Like 3 (Leydig Cell)1 2     Insulin-Like 32
RLNL1 2 3     ley-I-L2
Relaxin-Like Factor1 3     Leydig Insulin -Like Hormone2
prepro-INSL31 2     Relaxin-Like Factor B2
Leydig Insulin-Like Peptide2 3     Ley-I-L3
RLF2 3     

External Ids:    HGNC: 60861   Entrez Gene: 36402   Ensembl: ENSG000002480997   OMIM: 1467385   UniProtKB: P514603   

Export aliases for INSL3 gene to outside databases

Previous GC identifers: GC19M018421 GC19M018319 GC19M017772 GC19M017788 GC19M017492


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for INSL3 Gene:
This gene encodes a member of the insulin-like hormone superfamily. The encoded protein is mainly produced in
gonadal tissues. Studies of the mouse counterpart suggest that this gene may be involved in the development of
urogenital tract and female fertility. This protein may also act as a hormone to regulate growth and
differentiation of gubernaculum, and thus mediating intra-abdominal testicular descent. Mutations in this gene
may lead to cryptorchidism. Alternate splicing results in multiple transcript variants. (provided by RefSeq, May
2012)

GeneCards Summary for INSL3 Gene: 
INSL3 (insulin-like 3 (Leydig cell)) is a protein-coding gene. Diseases associated with INSL3 include cryptorchidism, and cryptorchidism, idiopathic, and among its related super-pathways are Signaling by GPCR and GPCR ligand binding. GO annotations related to this gene include protease binding and receptor binding.

UniProtKB/Swiss-Prot: INSL3_HUMAN, P51460
Function: Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent
in fetal life. Is a ligand for LGR8 receptor

Gene Wiki entry for INSL3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the INSL3 gene promoter:
         c-Fos   STAT5B   RP58   AP-1   JunB   Fra-1   FosB   HNF-4alpha2   HNF-4alpha1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidINSL3 promoter sequence
   Search SABiosciences Chromatin IP Primers for INSL3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INSL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2-p12   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.2-p12

INSL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INSL3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M017928:  view genomic region     (about GC identifiers)

Start:
17,927,321 bp from pter      End:
17,932,383 bp from pter
Size:
5,063 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: INSL3_HUMAN, P51460 (See protein sequence)
Recommended Name: Insulin-like 3 precursor  
Size: 131 amino acids; 14502 Da
Subunit: Heterodimer of a B chain and an A chain linked by two disulfide bonds
Subcellular location: Secreted
Sequence caution: Sequence=CAA52017.1; Type=Erroneous gene model prediction;
3 PDB 3D structures from and Proteopedia for INSL3:
2H8B (3D)        2K6T (3D)        2K6U (3D)    
Secondary accessions: B4DZ72 G3XAG0 Q3KPI5 Q3KPI6 Q6YNB5 Q9UEA2 Q9UPH6
Alternative splicing: 2 isoforms:  P51460-1   P51460-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for INSL3: NX_P51460

Explore proteomics data for INSL3 at MOPED 

INSL3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

INSL3 Protein Expression

REFSEQ proteins (2 alternative transcripts): 
NP_001252516.1  NP_005534.2  

ENSEMBL proteins: 
 ENSP00000321724   ENSP00000469309   ENSP00000369017  
Reactome Protein details: P51460
Human Recombinant Protein Products for INSL3: 
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Novus Biologicals INSL3 Lysate
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Cloud-Clone Corp. Proteins for INSL3 

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005615extracellular space IEA--
GO:0048471perinuclear region of cytoplasm IEA--

INSL3 for ontologies           About GeneDecksing



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LSBio Antibodies in human, mouse, rat for INSL3 

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Cloud-Clone Corp. ELISAs for INSL3 
Cloud-Clone Corp. CLIAs for INSL3


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
ENDOLIG: Endogenous ligands

2 InterPro protein domains:
 IPR016179 Insulin-like
 IPR022353 Insulin_CS

Graphical View of Domain Structure for InterPro Entry P51460

ProtoNet protein and cluster: P51460

1 Blocks protein domain: IPB004825 Insulin/IGF/relaxin

UniProtKB/Swiss-Prot: INSL3_HUMAN, P51460
Similarity: Belongs to the insulin family


INSL3 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: INSL3_HUMAN, P51460
Function: Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent
in fetal life. Is a ligand for LGR8 receptor

     Genatlas biochemistry entry for INSL3:
Leydig insulin-like protein 3,member of the insulin-like superfamily

     Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001664G-protein coupled receptor binding IEA--
GO:0002020protease binding IPI--
GO:0005102receptor binding TAS8020942
GO:0005158insulin receptor binding TAS8253799
GO:0005179hormone activity IEA--
     
INSL3 for ontologies           About GeneDecksing


Phenotypes:
     4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Insl3):
 behavior/neurological  endocrine/exocrine gland  reproductive system  skeleton 

INSL3 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Insl3tm1Imad for INSL3

   inGenious Targeting Laboratory - Custom generated mouse model solutions for INSL3 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for INSL3

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for INSL3 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for INSL3 

miRNA
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Inhib. RNA
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Gene Editing
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Clone
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GenScript: all cDNA clones in your preferred vector: INSL3 (NM_005543)
Sino Biological Human cDNA Clone for INSL3
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INSL3
Sirion Biotech Customized lentivirus for stable overexpression of INSL3 
                     Customized lentivirus expression plasmids for stable overexpression of INSL3 

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INSL3


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for INSL3 About                                                                                                See pathways by source

SuperPathContained pathways About
1Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.55
GPCR downstream signaling0.90
2Class A/1 (Rhodopsin-like receptors)
Class A/1 (Rhodopsin-like receptors)0.71
Peptide ligand-binding receptors0.60
GPCR ligand binding0.71
3Prostacyclin signalling through prostacyclin receptor
G alpha (s) signalling events0.31
4Relaxin receptors
Relaxin receptors

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



5/8        Reactome Pathways for INSL3 (see all 8)
    GPCR downstream signaling
Peptide ligand-binding receptors
Signaling by GPCR
GPCR ligand binding
Class A/1 (Rhodopsin-like receptors)



INSL3 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for INSL3

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for INSL3 (P514603 ENSP000003217244) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
RXFP2Q8WXD03, ENSP000002983864I2D: score=2 STRING: ENSP00000298386
INSRENSP000003038304STRING: ENSP00000303830
CCNB1IP1ENSP000003373964STRING: ENSP00000337396
About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001556oocyte maturation IEA--
GO:0001701in utero embryonic development IEA--
GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA--
GO:0007267cell-cell signaling TAS8253799
GO:0007283spermatogenesis TAS8253799

INSL3 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

INSL3 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for INSL3

10/12 Novoseek inferred chemical compound relationships for INSL3 gene (see all 12)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
phthalate esters 65.1 1 18949836 (1)
testosterone 64.6 72 18499751 (6), 16804040 (4), 19226271 (4), 19416189 (3) (see all 28)
phthalate 46.4 1 17258888 (1)
3beta-hydroxysteroid 26.7 2 9239733 (1), 10519633 (1)
diethylstilbestrol 21.4 2 12684664 (1)
alanine 16.8 1 11380919 (1)
threonine 9.93 1 11380919 (1)
valine 2.93 1 12464361 (1)
lysine 0 1 15209497 (1)
steroid 0 1 14687758 (1)

Search CenterWatch for drugs/clinical trials and news about INSL3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for INSL3 gene (2 alternative transcripts): 
NM_001265587.1  NM_005543.3  

Unigene Cluster for INSL3:

Insulin-like 3 (Leydig cell)
Hs.37062  [show with all ESTs]
Unigene Representative Sequence: BM560108
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000317306(uc002nhm.1) ENST00000598577 ENST00000379695(uc010ebf.1)

miRNA
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SwitchGear 3'UTR luciferase reporter plasmidINSL3 3' UTR sequence
Inhib. RNA
Products:
     
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for INSL3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INSL3
Sirion Biotech Customized lentivirus for stable overexpression of INSL3 
                     Customized lentivirus expression plasmids for stable overexpression of INSL3 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for INSL3
OriGene qSTAR qPCR primer pairs in human, mouse for INSL3
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat INSL3
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INSL3
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INSL3

Additional mRNA sequence: 

AK302780.1 AY082014.1 BC032810.1 BC040435.1 BC053345.1 BC061886.1 BC071706.1 BC106721.1 
BC106722.1 BC107045.2 S72482.1 

4 DOTS entries:

DT.105201  DT.97798826  DT.91751496  DT.95082839 

24/48 AceView cDNA sequences (see all 48):

NM_005543 U31602 BC040435 BI829405 CR608936 BC053345 AY082014 BI831038 
BI827691 BI828132 BC061886 BI825830 BX386607 AI825066 BM560108 BI831421 
BI827219 BI826252 BM553309 BX108627 BI520101 BI828079 BC032810 S72482 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

INSL3 expression in normal human tissues (normalized intensities)      INSL3 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TGTAACACCC
INSL3 Expression
About this image


INSL3 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/4 selected tissues (see all 4) fully expand
 
 Testis (Reproductive System)    fully expand to see all 3 entries
         XY Germ Cells Testis Cord
         Testis Interstitium
 
 Gonad
         XY Germ Cells Testis Cord
 
 Ovary (Reproductive System)
 
 Brain (Nervous System)

See INSL3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for INSL3

SOURCE GeneReport for Unigene cluster: Hs.37062

UniProtKB/Swiss-Prot: INSL3_HUMAN, P51460
Tissue specificity: Expressed in prenatal and postnatal Leydig cells. Found as well in the corpus luteum,
trophoblast, fetal membranes and breast

    SABiosciences Expression via Pathway-Focused PCR Array including INSL3: 
          Insulin Signaling Pathway in human mouse rat

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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INSL3
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INSL3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for INSL3 gene from 1/6 species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Insl31 , 5 insulin-like 31, 5 68.64(n)1
61.02(a)1
  8 (34.43 cM)5
163361  NM_013564.71  NP_038592.31 
 716892145 


ENSEMBL Gene Tree for INSL3 (if available)
TreeFam Gene Tree for INSL3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/225 SNPs in INSL3 are shown (see all 225)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0171224
Cryptorchidism (CRYPTO)4--see VAR_0171222 N K mis40--------
VAR_0132364
Cryptorchidism (CRYPTO)4--see VAR_0132362 R C mis40--------
rs1048946971,2,4
CCryptorchidism (CRYPTO)4 pathogenic117859062(-) GCAGCC/TCCTGC 4 P S L mis12Minor allele frequency- T:0.00NA 4726
rs1219125561,2
Cpathogenic117859035(-) TCACCA/GCCACC 4 T A H R mis10--------
rs1048946981,2
Cpathogenic117859036(-) ATCACC/TGCCAC 4 T R C syn1 mis10--------
VAR_0132374
----see VAR_0132372 R H mis40--------
VAR_0132324
----see VAR_0132322 V L mis40--------
VAR_0132334
----see VAR_0132332 P S mis40--------
rs110860801,2
C,F,A,H--17858322(+) TTTTCC/TGACAT 2 -- ds500130Minor allele frequency- N:0.00EA NA NS WA CSA 2986
rs1509125221,2
C--17858362(+) AGTCCG/TCAATG 2 -- ds50010--------

HapMap Linkage Disequilibrium report for INSL3 (17927321 - 17932383 bp)

Structural Variations
     Database of Genomic Variants (DGV) 8 variations for INSL3:    About this table     
Variant IDTypeSubtypePubMed ID
dgv3764n71CNV Loss21882294
dgv50n68CNV Loss17160897
nsv911220CNV Loss21882294
nsv911214CNV Loss21882294
nsv911219CNV Loss21882294
dgv3766n71CNV Loss21882294
nsv911209CNV Loss21882294
nsv911221CNV Loss21882294


Human Gene Mutation Database (HGMD): INSL3
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing INSL3
DNA2.0 Custom Variant and Variant Library Synthesis for INSL3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 146738   
OMIM disorders: 219050  
UniProtKB/Swiss-Prot: INSL3_HUMAN, P51460
  • Cryptorchidism (CRYPTO) [MIM:219050]: One of the most frequent congenital abnormalities in humans,
    involving 2-5% of male births. Cryptorchidism is associated with increased risk of infertility and testicular
    cancer. Note=The disease may be caused by mutations affecting the gene represented in this entry

  • 20/25 diseases for INSL3 (see all 25):    About MalaCards
    cryptorchidism    cryptorchidism, idiopathic    testicular disease    anorchia
    hyperandrogenism    testicular cancer    sertoli-leydig cell tumor    leydig cell tumor
    klinefelter's syndrome    goiter    azoospermia    hypospadias
    severe combined immunodeficiency    male infertility    infertility    polycystic ovary syndrome
    thyroid cancer    obesity    meningioma    thyroiditis

    4 diseases from the University of Copenhagen DISEASES database for INSL3:
    Cryptorchidism     Testicular cancer     Infertility     Hypospadias

    INSL3 for disorders           About GeneDecksing

    10/15 Novoseek inferred disease relationships for INSL3 gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cryptorchidism 90.4 84 11992081 (5), 15533513 (4), 11383919 (4), 11380919 (4) (see all 39)
    testicular dysgenesis 84.1 3 16687567 (1), 19329805 (1)
    testicular cancer 66.5 4 16687567 (2), 15755855 (1)
    testicular diseases 59.8 1 15755855 (1)
    azoospermia 43.9 2 17314233 (2)
    infertility 42.6 5 16687567 (2), 15956751 (1), 15579743 (1)
    thyroid carcinoma 30.5 9 12684664 (3), 19416220 (1), 16010410 (1), 19950223 (1)
    hyperandrogenism 25.5 4 16926256 (2), 17356050 (2)
    hyperplasia 7.81 6 10202675 (3), 10065864 (2), 15956746 (1)
    goiter 6.98 1 12684664 (1)

    Genetic Association Database (GAD): INSL3
    Human Genome Epidemiology (HuGE) Navigator: INSL3 (19 documents)

    Export disorders for INSL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for INSL3 gene, integrated from 9 sources (see all 203):
    (articles sorted by number of sources associating them with INSL3)
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    1. Ala/Thr60 variant of the Leydig insulin-like hormone is not associated with cryptorchidism in the Japanese population. (PubMed id 11380919)1, 2, 4, 9 Takahashi I.... Takada G. (2001)
    2. Different insulin-like 3 (INSL3) gene mutations not associated with human cryptorchidism. (PubMed id 11383919)1, 2, 4, 9 Marin P.... Foresta C. (2001)
    3. Insulin-like 3/relaxin-like factor gene mutations are associated with cryptorchidism. (PubMed id 11095425)1, 2, 4, 9 Tomboc M....Witchel S.F. (2000)
    4. Genetic analysis of the INSL3 gene in patients with maldescent of the testis. (PubMed id 11182749)1, 2, 4, 9 Lim H.N....Hughes I.A. (2001)
    5. Structural organization of the porcine and human genes coding for a Leydig cell-specific insulin-like peptide (LEY I-L) and chromosomal localization of the human gene (INSL3). (PubMed id 8020942)1, 2, 3, 9 Burkhardt E....Engel W. (1994)
    6. Mutation and polymorphism analyses of INSL3 and LGR8/GREAT in 62 Japanese patients with cryptorchidism. (PubMed id 17028442)1, 4, 9 Yamazawa K....Ogata T. (2007)
    7. Solution structure of a conformationally restricted fully active derivative of the human relaxin-like factor. (PubMed id 19086273)1, 2, 9 BA1llesbach E.E....Led J.J. (2008)
    8. Insulin-like factor 3 gene mutations in testicular dysgenesis syndrome: clinical and functional characterization. (PubMed id 16687567)1, 4, 9 Ferlin A....Foresta C. (2006)
    9. A common polymorphism in the human relaxin-like factor (RLF) gene: no relationship with cryptorchidism. (PubMed id 10759163)1, 2, 9 Koskimies P.... Toppari J. (2000)
    10. Mutations in INSL3 and RXFP2 genes in cryptorchid boys. (PubMed id 19416190)1, 4, 9 Ferlin A....Foresta C. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3640 HGNC: 6086 AceView: INSL3 Ensembl:ENSG00000248099 euGenes: HUgn3640
    ECgene: INSL3 H-InvDB: INSL3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for INSL3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for INSL3 gene:
    Search GeneIP for patents involving INSL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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