Aliases for INSIG2 Gene
External Ids for INSIG2 Gene
Previous GeneCards Identifiers for INSIG2 Gene
The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi. [provided by RefSeq, Jul 2008]
GeneCards Summary for INSIG2 Gene
INSIG2 (Insulin Induced Gene 2) is a Protein Coding gene. Diseases associated with INSIG2 include morbid obesity. Among its related pathways are Metabolism and Regulation of cholesterol biosynthesis by SREBP (SREBF). GO annotations related to this gene include transcription factor binding. An important paralog of this gene is INSIG1.
UniProtKB/Swiss-Prot for INSIG2 Gene
Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR.