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Aliases for INSIG2 Gene

Aliases for INSIG2 Gene

  • Insulin Induced Gene 2 2 3
  • INSIG-2 3 4
  • Insulin-Induced Gene 2 Protein 3
  • Insulin Induced Protein 2 3
  • INSIG2 Membrane Protein 3

External Ids for INSIG2 Gene

Previous GeneCards Identifiers for INSIG2 Gene

  • GC02P116766
  • GC02P118752
  • GC02P118949
  • GC02P118941
  • GC02P118562
  • GC02P111173
  • GC02P118846

Summaries for INSIG2 Gene

Entrez Gene Summary for INSIG2 Gene

  • The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi. [provided by RefSeq, Jul 2008]

GeneCards Summary for INSIG2 Gene

INSIG2 (Insulin Induced Gene 2) is a Protein Coding gene. Diseases associated with INSIG2 include obesity. Among its related pathways are Regulation of Cholesterol Biosynthesis by SREBP (SREBF) and Metabolism. GO annotations related to this gene include transcription factor binding. An important paralog of this gene is INSIG1.

UniProtKB/Swiss-Prot for INSIG2 Gene

  • Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR.

Gene Wiki entry for INSIG2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INSIG2 Gene

Genomics for INSIG2 Gene

Regulatory Elements for INSIG2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for INSIG2 Gene

Start:
118,088,452 bp from pter
End:
118,110,997 bp from pter
Size:
22,546 bases
Orientation:
Plus strand

Genomic View for INSIG2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for INSIG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INSIG2 Gene

Proteins for INSIG2 Gene

  • Protein details for INSIG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5U4-INSI2_HUMAN
    Recommended name:
    Insulin-induced gene 2 protein
    Protein Accession:
    Q9Y5U4
    Secondary Accessions:
    • A8K5W8
    • Q8TBI8

    Protein attributes for INSIG2 Gene

    Size:
    225 amino acids
    Molecular mass:
    24778 Da
    Quaternary structure:
    • Binds to the SCAP-SREBF2 complex only in the presence of sterols. Interacts with RNF139.
    Miscellaneous:
    • Does not require nuclear SREBPs for its expression. When nuclear SREBP activity is low, is the only form of INSIG present in the cell
    SequenceCaution:
    • Sequence=AAD43048.1; Type=Frameshift; Positions=221; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for INSIG2 Gene

neXtProt entry for INSIG2 Gene

Proteomics data for INSIG2 Gene at MOPED

Post-translational modifications for INSIG2 Gene

  • Ubiquitination at Lys216
  • Modification sites at PhosphoSitePlus

Other Protein References for INSIG2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for INSIG2 Gene

Domains for INSIG2 Gene

Protein Domains for INSIG2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for INSIG2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y5U4

UniProtKB/Swiss-Prot:

INSI2_HUMAN :
  • Q9Y5U4
Family:
  • Belongs to the INSIG family.
genes like me logo Genes that share domains with INSIG2: view

No data available for Gene Families for INSIG2 Gene

Function for INSIG2 Gene

Molecular function for INSIG2 Gene

UniProtKB/Swiss-Prot Function: Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR.

Gene Ontology (GO) - Molecular Function for INSIG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12242332
GO:0008134 transcription factor binding IEA --
genes like me logo Genes that share ontologies with INSIG2: view
genes like me logo Genes that share phenotypes with INSIG2: view

Animal Models for INSIG2 Gene

MGI Knock Outs for INSIG2:

Animal Model Products

CRISPR Products

miRNA for INSIG2 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for INSIG2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for INSIG2 Gene

Localization for INSIG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for INSIG2 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for INSIG2 Gene COMPARTMENTS Subcellular localization image for INSIG2 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for INSIG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0032937 SREBP-SCAP-Insig complex IDA 12242332
genes like me logo Genes that share ontologies with INSIG2: view

Pathways for INSIG2 Gene

genes like me logo Genes that share pathways with INSIG2: view

Pathways by source for INSIG2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for INSIG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006641 triglyceride metabolic process IEA --
GO:0006695 cholesterol biosynthetic process IEA --
GO:0006991 response to sterol depletion --
GO:0008203 cholesterol metabolic process --
GO:0010894 negative regulation of steroid biosynthetic process IEA --
genes like me logo Genes that share ontologies with INSIG2: view

Transcripts for INSIG2 Gene

Unigene Clusters for INSIG2 Gene

Insulin induced gene 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for INSIG2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for INSIG2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8
SP1: - -
SP2: -
SP3: - - - -
SP4: -
SP5:
SP6:

Relevant External Links for INSIG2 Gene

GeneLoc Exon Structure for
INSIG2
ECgene alternative splicing isoforms for
INSIG2

Expression for INSIG2 Gene

mRNA expression in normal human tissues for INSIG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for INSIG2 Gene

SOURCE GeneReport for Unigene cluster for INSIG2 Gene Hs.7089

genes like me logo Genes that share expressions with INSIG2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for INSIG2 Gene

Orthologs for INSIG2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for INSIG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INSIG2 35
  • 99.7 (n)
  • 100 (a)
INSIG2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia INSIG2 35
  • 96 (n)
  • 99.11 (a)
INSIG2 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia INSIG2 35
  • 94.52 (n)
  • 97.78 (a)
INSIG2 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Insig2 35
  • 87.41 (n)
  • 96.89 (a)
Insig2 16
Insig2 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia INSIG2 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Insig2 35
  • 86.07 (n)
  • 96.44 (a)
chicken
(Gallus gallus)
Aves INSIG2 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia INSIG2 36
  • 84 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii insig2 35
  • 67.58 (n)
  • 80.91 (a)
insig2 36
  • 78 (a)
OneToOne
Species with no ortholog for INSIG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for INSIG2 Gene

ENSEMBL:
Gene Tree for INSIG2 (if available)
TreeFam:
Gene Tree for INSIG2 (if available)

Paralogs for INSIG2 Gene

Paralogs for INSIG2 Gene

Selected SIMAP similar genes for INSIG2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with INSIG2: view

Variants for INSIG2 Gene

Sequence variations from dbSNP and Humsavar for INSIG2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs889903 -- 118,102,985(-) TATTG(C/T)AAATG intron-variant
rs889904 -- 118,102,895(-) GATTC(A/G)TGCTA intron-variant
rs929912 -- 118,100,217(-) CTTCA(C/T)GGAAA intron-variant
rs929913 -- 118,100,130(-) GGACA(A/T)TCATG intron-variant
rs1352083 -- 118,090,265(-) TTAGC(C/T)GTAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for INSIG2 Gene

Variant ID Type Subtype PubMed ID
esv2596819 CNV Deletion 19546169
esv21565 CNV Loss 19812545
nsv820793 CNV Deletion 20802225
esv2720611 CNV Deletion 23290073
esv2269282 CNV Deletion 18987734
esv1042101 CNV Deletion 17803354
esv1527073 CNV Deletion 17803354
esv1244468 CNV Deletion 17803354
esv1675960 CNV Deletion 17803354

Relevant External Links for INSIG2 Gene

HapMap Linkage Disequilibrium report
INSIG2
Human Gene Mutation Database (HGMD)
INSIG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INSIG2 Gene

Disorders for INSIG2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for INSIG2 Gene including...

Search for INSIG2 Gene in MalaCards »

Relevant External Links for INSIG2

Genetic Association Database (GAD)
INSIG2
Human Genome Epidemiology (HuGE) Navigator
INSIG2
genes like me logo Genes that share disorders with INSIG2: view

No data available for UniProtKB/Swiss-Prot for INSIG2 Gene

Publications for INSIG2 Gene

  1. Association between the insulin-induced gene 2 (INSIG2) and weight gain in a German sample of antipsychotic-treated schizophrenic patients: perturbation of SREBP-controlled lipogenesis in drug-related metabolic adverse effects? (PMID: 18195716) Le Hellard S. … Steen V.M. (Mol. Psychiatry 2009) 3 23 48
  2. No association between INSIG2 Gene rs7566605 polymorphism and being overweight in Japanese population. (PMID: 18223638) Tabara Y. … Kohara K. (Obesity (Silver Spring) 2008) 3 23 48
  3. Insulin-induced gene 2 involvement in human adipocyte metabolism and body weight regulation. (PMID: 18319320) Krapivner S. … van't Hooft F.M. (J. Clin. Endocrinol. Metab. 2008) 3 23 48
  4. Association of morbid obesity with FTO and INSIG2 allelic variants. (PMID: 18347269) Chu X. … Gerhard G.S. (Arch Surg 2008) 3 23 48
  5. The INSIG1 gene, not the INSIG2 gene, associated with coronary heart disease: tagSNPs and haplotype-based association study. The Beijing Atherosclerosis Study. (PMID: 18989534) Liu X. … Gu D. (Thromb. Haemost. 2008) 3 23 48

Products for INSIG2 Gene

Sources for INSIG2 Gene

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