INSIG2 Gene
protein-coding GIFtS: 53
GCID: GC02P118846
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|
insulin induced gene 2
| |
Aliases
for INSIG2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Insulin Induced Gene 21 2 | | INSIG-22 3 | | INSIG2 Membrane Protein2 | | Insulin Induced Protein 22 | | Insulin-Induced Gene 2 Protein2 |
Export aliases for INSIG2 gene to outside databasesPrevious GC identifers: GC02P116766 GC02P118752 GC02P118949 GC02P118941 GC02P118562 GC02P111173 |
Summaries
for INSIG2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for INSIG2:
The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 proteinand this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element bindingproteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPsto the Golgi. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: INSI2_HUMAN, Q9Y5U4Function: Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking theprocessing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in theER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomaldegradation of HMGCR
Gene Wiki entry for INSIG2
|
Genomic Views
for INSIG2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022135.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the INSIG2 gene promoter:
E2F-3a E2F-4 RFX1 E2F-5 AML1a E2F-2 AREB6 PPAR-alpha E2F-1 E2F
Other transcription factors
Search SABiosciences Chromatin IP Primers for INSIG2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INSIG2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q14.2 Ensembl cytogenetic band: 2q14.2 HGNC cytogenetic band: 2q14.1INSIG2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P118846: view genomic region
(about GC identifiers)
Start:
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118,846,028 bp from pter |
End:
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118,868,573 bp from pter |
Size:
|
22,546 bases |
Orientation:
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plus strand |
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Proteins
for INSIG2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: INSI2_HUMAN, Q9Y5U4 (See
protein sequence)Recommended Name: Insulin-induced gene 2 protein Size: 225 amino acids; 24778 Da
Subunit: Binds to the SCAP-SREBF2 complex only in the presence of sterols. Interacts with RNF139
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Miscellaneous: Does not require nuclear SREBPs for its expression. When nuclear SREBP activity is low, is the only formof INSIG present in the cell
Sequence caution: Sequence=AAD43048.1; Type=Frameshift; Positions=221;
Secondary accessions: A8K5W8 Q8TBI8Explore the universe of human proteins at neXtProt for INSIG2: NX_Q9Y5U4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y5U4
INSIG2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057217.2
ENSEMBL proteins: ENSP00000400126 ENSP00000245787 Reactome Protein details: Q9Y5U4
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
INSIG2 for ontologies About GeneDecksing
INSIG2 Antibody Products:
Assay Products for INSIG2: |
Protein
Domains /
Families
for INSIG2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
INSIG2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y5U4ProtoNet protein and cluster: Q9Y5U4 UniProtKB/Swiss-Prot: INSI2_HUMAN, Q9Y5U4Similarity: Belongs to the INSIG family |
Function
for INSIG2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: INSI2_HUMAN, Q9Y5U4Function: Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking theprocessing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in theER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomaldegradation of HMGCR
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for INSIG2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INSIG2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
INSIG2 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Insig2tm1Mbjg for INSIG2
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Insig2):
INSIG2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for INSIG2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | SREBP1A/1C/2 is retained in the endoplasmic reticulum by SCAP:cholesterol:INSIG | | | 2 | Metabolism | | | 3 | Regulation of Cholesterol Biosynthesis by SREBP (SREBF) | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for INSIG2
5/7 
Reactome Pathways for INSIG2 (see all 7)
INSIG2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for INSIG2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/36 Interacting proteins for INSIG2 (Q9Y5U43 ENSP000002457874) via UniProtKB, MINT, STRING, and/or I2D (see all 36)About this table
Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006641 | triglyceride metabolic process |
IEA | -- | | GO:0006695 | cholesterol biosynthetic process |
IEA | -- | | GO:0006991 | response to sterol depletion |
-- | -- | | GO:0008203 | cholesterol metabolic process |
-- | -- | | GO:0010894 | negative regulation of steroid biosynthetic process |
IEA | -- |
INSIG2 for ontologies About GeneDecksing
|
Drugs & Compounds
for INSIG2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for INSIG2
Search CenterWatch for drugs/clinical trials and news about INSIG2 / INSI2
|
Transcripts
for INSIG2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for INSIG2 gene: NM_016133.2 Unigene Cluster for INSIG2: Insulin induced gene 2 Hs.7089 [show with all ESTs]Unigene Representative Sequence: BX6478057 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000411929 ENST00000471186 ENST00000245787(uc002tlk.3 uc010yye.2 uc002tll.3)
ENST00000485520 ENST00000467223 ENST00000488995 ENST00000479999
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for INSIG2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for INSIG2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: INSIG2 (NM_016133) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for INSIG2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INSIG2 |
Additional cDNA sequence: AF125392.1 AF527632.1 AK021692.1 AK291433.1 AK298599.1 AL080184.1 BC022475.1 BX647805.1 8 DOTS entries: DT.75113185 DT.448715 DT.95272239 DT.100651551 DT.95272243 DT.100837251 DT.99998325 DT.91745384 24/151 AceView cDNA sequences (see all 151): N93884 CK904498 CB161635 CA443247 BM699655 BX954158 AA701862 AI580316 CB156956 F03387 D79901 AA971573 BU627704 BQ446216 AA905619 AI027128 AI597696 CR595929 AI591315 AI248096 BX360862 AI478220 NM_016133 BX281443
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for INSIG2 (see all 6) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8 |
|---|
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| SP1: | | | | | | | - | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | - | | - | | - | | | | |
| SP4: | | | | | | | | | | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for INSIG2
|
Expression
for INSIG2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| INSIG2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTTCCTAGA
About this image
See INSIG2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for INSIG2
SOURCE GeneReport for Unigene cluster: Hs.7089
SABiosciences Expression via Pathway-Focused PCR Arrays including INSIG2:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for INSIG2
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INSIG2 |
Orthologs
for INSIG2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for INSIG2 gene from 4/13 species (see all 13) About this table
ENSEMBL Gene Tree for INSIG2 (if available)
TreeFam Gene Tree for INSIG2 (if available) |
Paralogs
for INSIG2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for INSIG2 gene
- INSIG12
1 SIMAP similar gene for INSIG2 using alignment to 2 protein entries: INSI2_HUMAN (see all proteins):INSIG1
INSIG2 for paralogs About GeneDecksing
|
Genomic Variants
for INSIG2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for INSIG2 (118846028 - 118868573 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for INSIG2
3 CNVs: 43996 74232 97951
2 Indels: 26418 26419
Human Gene Mutation Database (HGMD): INSIG2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing INSIG2 |
|
Disorders
/ Diseases
for INSIG2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
INSIG2 for disorders About GeneDecksing
OMIM gene information: 608660
OMIM disorders: --
20/21  diseases for INSIG2 (see all 21): About MalaCardssleep apnea esophageal squamous cell carcinoma squamous cell carcinoma coronary heart disease
morbid obesity apnea myocardial infarction obesity, association with
obesity esophagitis rabies esophageal cancer
pancreatic cancer breast cancer asthma pancreatitis
atherosclerosis carcinoma cholesterol hypoxia
Human Genome Epidemiology (HuGE) Navigator: INSIG2 (61 documents)
Export disorders for INSIG2 gene to outside databases
|
Publications
for INSIG2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for INSIG2 gene, integrated from 9 sources (see all 79):
(articles sorted by number of sources associating them with INSIG2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins. (PubMed id 12242332)1, 2, 3 Yabe D.... Goldstein J.L. (2002)
- Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasis. (PubMed id 16606821)1, 2 Gong Y.... Ye J. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Characterization of the human insulin-induced gene 2 (INSIG2) promoter: the role of Ets-binding motifs. (PubMed id 20145255)1, 9 FernA!ndez-Alvarez A....Casado M. (2010)
- Insulin-induced gene 2 involvement in human adipocyte metabolism and body weight regulation. (PubMed id 18319320)1, 9 Krapivner S....van't Hooft F.M. (2008)
- The INSIG1 gene, not the INSIG2 gene, associated with coronary heart disease: tagSNPs and haplotype-based association study. The Beijing Atherosclerosis Study. (PubMed id 18989534)1, 9 Liu X....Gu D. (2008)
- Association between the insulin-induced gene 2 (INSIG2) and weight gain in a German sample of antipsychotic-treated schizophrenic patients: perturbation of SREBP-controlled lipogenesis in drug-related metabolic adverse effects? (PubMed id 18195716)1, 9 Le Hellard S....Steen V.M. (2008)
- Association study of polymorphisms in Insulin Induced Gene 2 (INSIG2) with antipsychotic-induced weight gain in European and African -American schizophrenia patients. (PubMed id 20373477)1, 9 Tiwari A.K....Kennedy J.L. (2010)
- Interactions among genetic variants from SREBP2 activ ating-related pathway on risk of coronary heart disease in Chinese Han populati on. (PubMed id 19740467)1, 9 Liu X....Gu D. (2010)
- No association between INSIG2 Gene rs7566605 polymorphism and being overweight in Japanese population. (PubMed id 18223638)1, 9 Tabara Y....Kohara K. (2008)
|
External Searches for INSIG2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing INSIG2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing INSIG2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing INSIG2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for INSIG2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for INSIG2 gene:
Search GeneIP for patents involving INSIG2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for INSIG2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for INSIG2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for INSIG2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for INSIG2 | | | OriGene Protein Over-expression Lysate for INSIG2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for INSIG2 | | OriGene 3'-UTR Clone for INSIG2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for INSIG2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for INSIG2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for INSIG2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat INSIG2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing INSIG2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INSIG2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat INSIG2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INSIG2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INSIG2 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INSIG2 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INSIG2 |
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