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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

INSIG1 Gene

protein-coding   GIFtS: 57
GCID: GC07P155089

Insulin Induced Gene 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Insulin Induced Gene 11 2
INSIG-1 Membrane Protein1 2
CL-62
CL62
Insulin-Induced Gene 1 Protein2
INSIG-13

External Ids:    HGNC: 60831   Entrez Gene: 36382   Ensembl: ENSG000001864807   OMIM: 6020555   UniProtKB: O155033   

Export aliases for INSIG1 gene to outside databases

Previous GC identifers: GC07U990053 GC07P154481 GC07P154527 GC07P154720 GC07P148822


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for INSIG1 Gene:
Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory
element-binding protein (SREBP)-mediated signaling pathways. This gene is an insulin-induced gene. It encodes an
endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations
in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG
CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced
transcript variants encoding distinct isoforms have been observed. (provided by RefSeq, Jun 2009)

GeneCards Summary for INSIG1 Gene: 
INSIG1 (insulin induced gene 1) is a protein-coding gene. Diseases associated with INSIG1 include hcl-v, and coronary heart disease, and among its related super-pathways are Activation of Gene Expression by SREBP (SREBF) and Metabolic pathways. GO annotations related to this gene include protein binding. An important paralog of this gene is INSIG2.

UniProtKB/Swiss-Prot: INSI1_HUMAN, O15503
Function: Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking
the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2
complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated
ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase
to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in
metabolic control. May play a regulatory role during G0/G1 transition of cell growth

Gene Wiki entry for INSIG1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007741.14  NC_018918.2  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the INSIG1 gene promoter:
         Max1   SRF   SRF (504 AA)   IRF-1   LCR-F1   Egr-4   N-Myc   deltaCREB   SEF-1 (1)   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): INSIG1 promoter sequence
   Search SABiosciences Chromatin IP Primers for INSIG1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INSIG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q36   Ensembl cytogenetic band:  7q36.2   HGNC cytogenetic band: 7q36

INSIG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INSIG1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P155089:  view genomic region     (about GC identifiers)

Start:
155,089,486 bp from pter      End:
155,101,945 bp from pter
Size:
12,460 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 154,316,806-154,329,270     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: INSI1_HUMAN, O15503 (See protein sequence)
Recommended Name: Insulin-induced gene 1 protein  
Size: 277 amino acids; 29987 Da
Subunit: Binds to the SCAP-SREBF2 complex only in the presence of sterols. Interacts with RNF139. Interacts with
HMGCR (via its SSD); the interaction, accelerated by sterols, leads to the recruitment of HMGCR to AMFR/gp78 for
its ubiquitination by the sterol-mediated ERAD pathway. Interacts with AMFR/gp78 (via its membrane domain); the
interaction recruits HMCR at the ER membrane for its ubiquitination and degradation by the sterol-mediated ERAD
pathway
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Miscellaneous: Expressed at high levels when nuclear SREBP levels are high as a result of sterol deprivation
Secondary accessions: A4D2N1 A8K6L0 Q53XW8 Q9BUV5
Alternative splicing: 2 isoforms:  O15503-1   O15503-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for INSIG1: NX_O15503

Explore proteomics data for INSIG1 at MOPED 

Post-translational modifications:

  • UniProtKB: Ubiquitinated. Subsequent to sterol deprivation, the SCAP-SREBF2 complex becomes dissociated from INSIG1, is then
    ubiquitinated and degraded in proteasomes. Although ubiquitination is required for rapid INSIG1 degradation, it
    is not required for release of the SCAP-SREBP complex. Ubiquitinated by RNF139
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O15503

  • INSIG1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    INSIG1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_005533.2  NP_938150.2  NP_938151.1  

    ENSEMBL proteins: 
     ENSP00000344741   ENSP00000414691   ENSP00000344035   ENSP00000420198   ENSP00000340010  
    Reactome Protein details: O15503
    Human Recombinant Protein Products for INSIG1: 
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    Cloud-Clone Corp. Proteins for INSIG1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA12202038
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0032937SREBP-SCAP-Insig complex IDA15899885

    INSIG1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR009904 INSIG
     IPR025929 INSIG_fam

    Graphical View of Domain Structure for InterPro Entry O15503

    ProtoNet protein and cluster: O15503

    UniProtKB/Swiss-Prot: INSI1_HUMAN, O15503
    Similarity: Belongs to the INSIG family


    INSIG1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: INSI1_HUMAN, O15503
    Function: Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking
    the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2
    complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated
    ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase
    to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in
    metabolic control. May play a regulatory role during G0/G1 transition of cell growth
    Induction: By insulin

         Genatlas biochemistry entry for INSIG1:
    insulin induced gene 1,playing a role in growth and differention of tissues involved in metabolic control

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12202038
         
    INSIG1 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Insig1):
     homeostasis/metabolism  liver/biliary system  mortality/aging 

    INSIG1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Insig1tm1.1Mbjg for INSIG1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for INSIG1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for INSIG1

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    SwitchGear 3'UTR luciferase reporter plasmidINSIG1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for INSIG1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Regulation of Cholesterol Biosynthesis by SREBP (SREBF)
    Regulation of Cholesterol Biosynthesis by SREBP (SREBF)0.67
    SREBP signalling0.37
    2Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    3Chks in Checkpoint Regulation
    SREBP Proteolysis0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for INSIG1
        SREBP Proteolysis

    1 BioSystems Pathway for INSIG1
        SREBP signalling

    3        Reactome Pathways for INSIG1
        Metabolism
    Metabolism of lipids and lipoproteins
    Regulation of Cholesterol Biosynthesis by SREBP (SREBF)



    INSIG1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for INSIG1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/21 Interacting proteins for INSIG1 (O155031, 2, 3 ENSP000003447414) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AMFRQ9UKV53, ENSP000002906494I2D: score=1 STRING: ENSP00000290649
    PSMA7O148183, ENSP000003599104I2D: score=1 STRING: ENSP00000359910
    PSMC3P179803, ENSP000002988524I2D: score=1 STRING: ENSP00000298852
    VCPP550723, ENSP000003517774I2D: score=1 STRING: ENSP00000351777
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006641triglyceride metabolic process IEA--
    GO:0006695cholesterol biosynthetic process IEA--
    GO:0006991response to sterol depletion ----
    GO:0008152metabolic process TAS9268630
    GO:0008203cholesterol metabolic process ----

    INSIG1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    INSIG1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for INSIG1 (INSI1)

    3 Novoseek inferred chemical compound relationships for INSIG1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sterol 76.7 5 16399501 (2), 18319320 (1), 12242342 (1), 15073165 (1)
    cholesterol 49.2 12 16399501 (3), 12242342 (2), 12202038 (2), 18989534 (1) (see all 5)
    lipid 20.1 3 15073165 (2), 20064776 (1)

    Search CenterWatch for drugs/clinical trials and news about INSIG1 / INSI1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for INSIG1 gene (3 alternative transcripts): 
    NM_005542.4  NM_198336.2  NM_198337.2  

    Unigene Cluster for INSIG1:

    Insulin induced gene 1
    Hs.520819  [show with all ESTs]
    Unigene Representative Sequence: NM_005542
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000340368(uc003wly.3 uc003wlz.3) ENST00000425172 ENST00000342407
    ENST00000476756 ENST00000468307 ENST00000344756(uc011kvu.2)
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    SwitchGear 3'UTR luciferase reporter plasmidINSIG1 3' UTR sequence
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    Additional mRNA sequence: 

    AF086365.1 AK095977.1 AK291675.1 AY112745.1 BC001880.1 BT007227.1 

    23 DOTS entries:

    DT.100886430  DT.119206  DT.92058013  DT.97802062  DT.92460840  DT.100886435  DT.100886432  DT.40113830 
    DT.100037239  DT.86997566  DT.95365670  DT.95365683  DT.97848405  DT.99992459  DT.100886428  DT.100886438 
    DT.100886442  DT.100886441  DT.121125182  DT.40298043  DT.97848406  DT.95365667  DT.95365669 

    24/535 AceView cDNA sequences (see all 535):

    AI017392 BM763191 AI077546 BU857352 AA330124 CB146540 BG568530 AA723426 
    BQ070238 AA761137 BC001880 BG057282 BQ941600 AY112745 BG740701 BU615677 
    CD369759 AI380633 AI424827 CR596868 AA804438 BU860125 AW088876 BE268206 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for INSIG1 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d
    SP1:                                -                       -                       -                           
    SP2:                                                        -                                                   
    SP3:                                -           -     -     -                                                   
    SP4:                                -                 -     -     -     -           -                           
    SP5:                                                        -                                                   


    ECgene alternative splicing isoforms for INSIG1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    INSIG1 expression in normal human tissues (normalized intensities)      INSIG1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAAAAATTT
    INSIG1 Expression
    About this image


    INSIG1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Human Preadipocyte-subcutaneous (HPA-s)   
             Adipocyte   
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Peripheral blood-derived endothelial progenitor cells
             Human Umbilical Vein Smooth Muscle Cells (HUVSMC)   
     
     Smooth Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Human Umbillical Artery Smooth Muscle Cells (HUASMC)   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Human Umbillical Artery Smooth Muscle Cells (HUASMC)   
     
     Colon (Gastrointestinal Tract)
             Human Colonic Smooth Muscle Cells (HCoSMC)   

    See INSIG1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for INSIG1

    SOURCE GeneReport for Unigene cluster: Hs.520819

    UniProtKB/Swiss-Prot: INSI1_HUMAN, O15503
    Tissue specificity: Expressed in all tissues tested with highest expression in the liver

        SABiosciences Expression via Pathway-Focused PCR Arrays including INSIG1: 
              Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat
              Unfolded Protein Response in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for INSIG1 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Insig11 , 5 insulin induced gene 11, 5 81.21(n)1
    84.94(a)1
      5 (13.94 cM)5
    2310701  NM_153526.51  NP_705746.11 
     280713635 
    chicken
    (Gallus gallus)
    Aves INSIG11 insulin induced gene 1 78.49(n)
    84.68(a)
      420442  NM_001030966.1  NP_001026137.1 
    lizard
    (Anolis carolinensis)
    Reptilia INSIG16
    Uncharacterized protein
    79(a)
    1 ↔ 1
    6(5579862-5590325)
    zebrafish
    (Danio rerio)
    Actinopterygii wufi35b102 wufi35b10 74.82(n)   334189  AF527626.1 


    ENSEMBL Gene Tree for INSIG1 (if available)
    TreeFam Gene Tree for INSIG1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for INSIG1 gene
    INSIG22  
    1 SIMAP similar gene for INSIG1 using alignment to 5 protein entries:     INSI1_HUMAN (see all proteins):
    INSIG2

    INSIG1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/328 SNPs in INSIG1 are shown (see all 328)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0276834
    ----see VAR_0276832 A T mis40--------
    rs1414172911,2
    --155091249(+) CTCAAC/TTCTAT 3 -- int10--------
    rs1807564111,2
    --155091299(+) CCCCTA/GTCCTT 3 -- int10--------
    rs1145184841,2
    C,F--155091305(+) TCCTTA/GAGCAG 3 -- int11Minor allele frequency- G:0.05WA 118
    rs97678751,2
    C,F,H--155091406(+) CAGCTG/TACTGC 3 -- int125Minor allele frequency- T:0.18NA NS EA WA CSA 2532
    rs1849605641,2
    --155091546(+) AAGCCA/GTCGTT 3 -- int10--------
    rs97678871,2
    C,F--155091579(+) GTAGGT/CGTGTC 3 -- int17Minor allele frequency- C:0.18NA WA EA 366
    rs97711741,2
    C,F,A,H--155091671(+) GGGCTC/GCGTGT 3 -- int18Minor allele frequency- G:0.08NS NA WA EA 486
    rs97703591,2
    C,F,A--155091678(+) GTGTTG/CAAGAA 3 -- int16Minor allele frequency- C:0.15NA WA EA 246
    rs1910760881,2
    --155091717(+) AGTGGA/GTAGAA 3 -- int10--------

    HapMap Linkage Disequilibrium report for INSIG1 (155089486 - 155101945 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for INSIG1: --

    Human Gene Mutation Database (HGMD): INSIG1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing INSIG1
    DNA2.0 Custom Variant and Variant Library Synthesis for INSIG1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602055    OMIM disorders: --

    6 diseases for INSIG1:    About MalaCards
    hcl-v    coronary heart disease    atherosclerosis    obesity
    gastric cancer    hepatitis


    INSIG1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): INSIG1
    Human Genome Epidemiology (HuGE) Navigator: INSIG1 (13 documents)

    Export disorders for INSIG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for INSIG1 gene, integrated from 9 sources (see all 63):
    (articles sorted by number of sources associating them with INSIG1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, human chromosomal assignment, and adipose and hepatic expression of the CL-6/INSIG1 gene. (PubMed id 9268630)1, 2, 3 Peng Y.... Taub R. (1997)
    2. Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake. (PubMed id 16399501)1, 2, 9 Gong Y.... Ye J. (2006)
    3. The INSIG1 gene, not the INSIG2 gene, associated with coronary heart disease: tagSNPs and haplotype-based association study. The Beijing Atherosclerosis Study. (PubMed id 18989534)1, 4, 9 Liu X....Gu D. (2008)
    4. Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER. (PubMed id 12202038)1, 2, 9 Yang T.... Brown M.S. (2002)
    5. Interactions among genetic variants from SREBP2 activ ating-related pathway on risk of coronary heart disease in Chinese Han populati on. (PubMed id 19740467)1, 4, 9 Liu X....Gu D. (2010)
    6. Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase. (PubMed id 16168377)1, 2, 9 Song B.L....DeBose-Boyd R.A. (2005)
    7. No association between polymorphisms in the INSIG1 ge ne and the risk of type 2 diabetes and related traits. (PubMed id 20444954)1, 4 Szopa M....Loos R.J. (2010)
    8. INSIG1 influences obesity-related hypertriglyceridemi a in humans. (PubMed id 19965593)1, 4 Smith E.M....Olivier M. (2010)
    9. The TRC8 ubiquitin ligase is sterol regulated and int eracts with lipid and protein biosynthetic pathways. (PubMed id 20068067)1, 2 Lee J.P....Gemmill R.M. (2010)
    10. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3638 HGNC: 6083 AceView: INSIG1 Ensembl:ENSG00000186480 euGenes: HUgn3638
    ECgene: INSIG1 H-InvDB: INSIG1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for INSIG1 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Insig1

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for INSIG1 gene:
    Search GeneIP for patents involving INSIG1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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