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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

INSIG1 Gene

protein-coding GIFtS: 55
GCID: GC07P155089

insulin induced gene 1

Explore 7 diseases affiliated with
INSIG1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Insulin Induced Gene 1¹ ²		INSIG-1 Membrane Protein²
CL-6¹ ²		Insulin-Induced Gene 1 Protein²
MGC1405¹		INSIG-1³
CL6²

External Ids:	HGNC: 6083¹	Entrez Gene: 3638²	Ensembl: ENSG00000186480⁷	OMIM: 602055⁵	UniProtKB: O15503³

Export aliases for INSIG1 gene to outside databases

Previous GC identifers: GC07U990053 GC07P154481 GC07P154527 GC07P154720 GC07P148822

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for INSIG1:

Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding

protein (SREBP)-mediated signaling pathways. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum

(ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds

to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for

the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct

isoforms have been observed. (provided by RefSeq, Jun 2009)

UniProtKB/Swiss-Prot: INSI1_HUMAN, O15503

Function: Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the

processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the

ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic

reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78.

May play a role in growth and differentiation of tissues involved in metabolic control. May play a regulatory role

during G0/G1 transition of cell growth

Gene Wiki entry for INSIG1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007741.14 NT_079596.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the INSIG1 gene promoter:
Max1 SRF SRF (504 AA) IRF-1 LCR-F1 Egr-4 N-Myc deltaCREB SEF-1 (1) c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): INSIG1 promoter sequence

Search SABiosciences Chromatin IP Primers for INSIG1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INSIG1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q36 Ensembl cytogenetic band: 7q36.2 HGNC cytogenetic band: 7q36

INSIG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INSIG1 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P155089: view genomic region (about GC identifiers)

Start:	155,089,486 bp from pter	End:	155,101,945 bp from pter
Size:	12,460 bases	Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 154,316,806-154,329,270

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: INSI1_HUMAN, O15503 (See protein sequence)

Recommended Name: Insulin-induced gene 1 protein

Size: 277 amino acids; 29987 Da

Subunit: Binds to the SCAP-SREBF2 complex only in the presence of sterols. Interacts with RNF139. Interacts with HMGCR

(via its SSD); the interaction, accelerated by sterols, leads to the recruitment of HMGCR to AMFR/gp78 for its

ubiquitination by the sterol-mediated ERAD pathway. Interacts with AMFR/gp78 (via its membrane domain); the

interaction recruits HMCR at the ER membrane for its ubiquitination and degradation by the sterol-mediated ERAD

pathway

Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein

Miscellaneous: Expressed at high levels when nuclear SREBP levels are high as a result of sterol deprivation

Secondary accessions: A4D2N1 A8K6L0 Q53XW8 Q9BUV5

Alternative splicing: 2 isoforms: O15503-1 O15503-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for INSIG1: NX_O15503

Post-translational modifications:

Ubiquitinated. Subsequent to sterol deprivation, the SCAP-SREBF2 complex becomes dissociated from INSIG1, is then

ubiquitinated and degraded in proteasomes. Although ubiquitination is required for rapid INSIG1 degradation, it is not

required for release of the SCAP-SREBP complex. Ubiquitinated by RNF139¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O15503

INSIG1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_005533.2 NP_938150.2 NP_938151.1

ENSEMBL proteins:

ENSP00000344741 ENSP00000414691 ENSP00000344035 ENSP00000420198 ENSP00000340010

Reactome Protein details: O15503
Human Recombinant Protein Products:

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	Uscn Proteins for INSIG1

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	IDA	12202038
GO:0005789	endoplasmic reticulum membrane	--	--
GO:0016021	integral to membrane	--	--
GO:0032937	SREBP-SCAP-Insig complex	IDA	15899885

INSIG1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for INSIG1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

INSIG1 for domains About GeneDecksing

2 InterPro domains/families:

IPR009904 INSIG

IPR025929 INSIG_fam

Graphical View of Domain Structure for InterPro Entry O15503

ProtoNet protein and cluster: O15503

UniProtKB/Swiss-Prot: INSI1_HUMAN, O15503

Similarity: Belongs to the INSIG family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: INSI1_HUMAN, O15503

Function: Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the

processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the

ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic

reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78.

May play a role in growth and differentiation of tissues involved in metabolic control. May play a regulatory role

during G0/G1 transition of cell growth

Induction: By insulin

Genatlas biochemistry entry for INSIG1:

insulin induced gene 1,playing a role in growth and differention of tissues involved in metabolic control

miRNA Products:		OriGene 3'-UTR Clone (see all 2): INSIG1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat INSIG1
		8/57 QIAGEN miScript miRNA Assays for microRNAs that regulate INSIG1 (see all 57):
		hsa-miR-21* hsa-miR-26a-2* hsa-miR-607 hsa-miR-300 hsa-miR-218-1* hsa-miR-25 hsa-miR-29a hsa-miR-301a

		SwitchGear 3'UTR luciferase reporter plasmid: INSIG1 3' UTR sequence

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Gene Editing
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for INSIG1
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INSIG1

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--

INSIG1 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Insig1^tm1.1Mbjg for INSIG1
     3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Insig1):

homeostasis/metabolism

liver/biliary system

mortality/aging

INSIG1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

SREBP1A/1C/2 is retained in the endoplasmic reticulum by SCAP:cholesterol:INSIG

	SREBP1A/1C/2 is retained in the endoplasmic reticulum by SCAP:cholesterol:INSIG	1.00			SREBP1A/1C/2 is retained in the endoplasmic reticulum by SCAP:INSIG:oxysterol	0.80
	SREBP1A/1C/2 is retained in the endoplasmic reticulum by SCAP:cholesterol:INSIG	0.80

Metabolism

Metabolism

1.00

Metabolism of lipids and lipoproteins

0.34

Regulation of Cholesterol Biosynthesis by SREBP (SREBF)

Regulation of Cholesterol Biosynthesis by SREBP (SREBF)

1.00

SREBP signalling

0.46

Ubiquitinated Orc1 is degraded by the proteasome

SREBP Proteolysis

0.40

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for INSIG1

SREBP Proteolysis

1 BioSystems Pathway for INSIG1

SREBP signalling

5/6 Reactome Pathways for INSIG1 (see all 6)

	SREBP1A/1C/2 is retained in the endoplasmic reticulum by SCAP:cholesterol:INSIG
	SREBP1A/1C/2 is retained in the endoplasmic reticulum by SCAP:cholesterol:INSIG
	Metabolism
	Metabolism of lipids and lipoproteins
	Regulation of Cholesterol Biosynthesis by SREBP (SREBF)

INSIG1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for INSIG1

STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

5/18 Interacting proteins for INSIG1 (O15503^{1, 3} ENSP00000344741⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 18)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AMFR	Q9UKV5³, ENSP00000290649⁴	I2D: score=1 STRING: ENSP00000290649
PSMA7	O14818³, ENSP00000359910⁴	I2D: score=1 STRING: ENSP00000359910
PSMC3	P17980³, ENSP00000298852⁴	I2D: score=1 STRING: ENSP00000298852
VCP	P55072³, ENSP00000351777⁴	I2D: score=1 STRING: ENSP00000351777
UBC	P0CG48³, ENSP00000344818⁴	I2D: score=1 STRING: ENSP00000344818

About this table

Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006641	triglyceride metabolic process	IEA	--
GO:0006695	cholesterol biosynthetic process	IEA	--
GO:0006991	response to sterol depletion	--	--
GO:0008152	metabolic process	TAS	9268630
GO:0008203	cholesterol metabolic process	--	--

INSIG1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

INSIG1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for INSIG1
3 Novoseek chemical compound relationships for INSIG1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
sterol	76.7	5	16399501 (2), 18319320 (1), 12242342 (1), 15073165 (1)
cholesterol	49.2	12	16399501 (3), 12242342 (2), 12202038 (2), 18989534 (1) (see all 5)
lipid	20.1	3	15073165 (2), 20064776 (1)

Search CenterWatch for drugs/clinical trials and news about INSIG1 / INSI1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for INSIG1 gene (3 alternative transcripts):

NM_005542.4 NM_198336.2 NM_198337.2

Unigene Cluster for INSIG1:

Insulin induced gene 1

Hs.520819 [show with all ESTs]

Unigene Representative Sequence: NM_005542

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000340368(uc003wly.3 uc003wlz.3) ENST00000425172 ENST00000342407

ENST00000476756 ENST00000468307 ENST00000344756(uc011kvu.2)

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		8/57 QIAGEN miScript miRNA Assays for microRNAs that regulate INSIG1 (see all 57):
		hsa-miR-21* hsa-miR-26a-2* hsa-miR-607 hsa-miR-300 hsa-miR-218-1* hsa-miR-25 hsa-miR-29a hsa-miR-301a

		SwitchGear 3'UTR luciferase reporter plasmid: INSIG1 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INSIG1

Additional cDNA sequence:

AF086365.1 AK095977.1 AK291675.1 AY112745.1 BC001880.1 BT007227.1

23 DOTS entries:

DT.100886430 DT.119206 DT.92058013 DT.97802062 DT.92460840 DT.100886435 DT.100886432 DT.40113830

DT.100037239 DT.86997566 DT.95365670 DT.95365683 DT.97848405 DT.100886441 DT.99992459 DT.100886428

DT.100886438 DT.100886442 DT.121125182 DT.40298043 DT.97848406 DT.95365667 DT.95365669

24/535 AceView cDNA sequences (see all 535):

NM_198336 AI280737 NM_005542 AA766318 BG248834 AI077546 BU857352 AA330124

CB146540 BG568530 AA723426 BQ070238 BG057282 BC001880 AA761137 BQ941600

AY112745 BG740701 BU615677 AI380633 CD369759 AI424827 CR596868 BU860125

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for INSIG1 (see all 6) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	^	2	^	3	^	4a	·	4b	^	5a	·	5b	^	6	^	7	^	8a	·	8b	·	8c	·	8d
SP1:											-								-								-
SP2:																			-
SP3:											-				-		-		-
SP4:											-						-		-		-		-				-
SP5:																			-

ECgene alternative splicing isoforms for INSIG1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

INSIG1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAAAAATTT

About this image

INSIG1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor SK17 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See INSIG1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for INSIG1

SOURCE GeneReport for Unigene cluster: Hs.520819

UniProtKB/Swiss-Prot: INSI1_HUMAN, O15503

Tissue specificity: Expressed in all tissues tested with highest expression in the liver

SABiosciences Expression via Pathway-Focused PCR Arrays including INSIG1:

Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

Unfolded Protein Response in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INSIG1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INSIG1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for INSIG1 gene from 3/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	INSIG1¹	insulin induced gene 1	78.49(n) 84.68(a)		420442 NM_001030966.1 NP_001026137.1
lizard (Anolis carolinensis)	Reptilia	INSIG1⁶	--	80(a)	1 ↔ 1	6(5584933-5590325)
zebrafish (Danio rerio)	Actinopterygii	wufi35b10²	wufi35b10	74.82(n)		334189 AF527626.1

ENSEMBL Gene Tree for INSIG1 (if available)
TreeFam Gene Tree for INSIG1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for INSIG1 gene

INSIG2²

1 SIMAP similar gene for INSIG1 using alignment to 5 protein entries: INSI1_HUMAN (see all proteins):

INSIG2

INSIG1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs9690258^1,2	C,F,A,H,	--	148820074(+)	`CAACCT/CTCCCA`	1	--	ds500¹		21	NS EA NA WA CSA	2059
rs1128640^1,2	C,	--	148820406(-)	`CAGACT/CACCCC`	1	--	nc-transcript-variant		3	MN NA	306
rs12154226^1,2	C,F,A,	--	148820681(+)	`GGGCTC/GCCGTG`	1	--	nc-transcript-variant		10	WA NA CSA	253
rs75800593^1,2	F,	--	148820701(+)	`CTCCAT/CGAGGT`	1	--	nc-transcript-variant		1	WA	118
rs12154352^1,2	C,F,A,	--	148820703(+)	`CCATGA/GGGTTA`	1	--	nc-transcript-variant		8	NA WA CSA	250
rs12154437^1,2	C,F,	--	148820706(+)	`TGAGGT/CTAGCA`	1	--	nc-transcript-variant		8	NA CSA WA	250
rs57116026^1,2	C,F,	--	148820758(+)	`GGGTCG/AAGGAG`	1	--	nc-transcript-variant		7	WA NA CSA	248
rs57297668^1,2	C,F,	--	148820784(+)	`CTGAAA/GGGTGC`	1	--	nc-transcript-variant		8	WA NA CSA	249
rs56780081^1,2	C,F,	--	148820841(+)	`CTCACT/CAGTTT`	1	--	nc-transcript-variant		9	WA NA CSA	251
rs14334^1,2	C,F,	--	148820866(+)	`GTGGGT/CAGCTT`	1	--	nc-transcript-variant		7	MN NA CSA	382

HapMap Linkage Disequilibrium report for INSIG1 (155089486 - 155101945 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for INSIG1: --
Human Gene Mutation Database (HGMD): INSIG1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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INSIG1 for disorders           About GeneDecksing

OMIM gene information: 602055    OMIM disorders: --

7 diseases for INSIG1:    About MalaCards

hcl-v cholesterol coronary heart disease gastric cancer

atherosclerosis obesity hepatitis

Human Genome Epidemiology (HuGE) Navigator: INSIG1 (13 documents)

Export disorders for INSIG1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for INSIG1 gene, integrated from 9 sources (see all 59):
(articles sorted by number of sources associating them with INSIG1)

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Cloning, human chromosomal assignment, and adipose and hepatic expression of the CL-6/INSIG1 gene. (PubMed id 9268630)^{1, 2, 3} Peng Y.... Taub R. (1997)
Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake. (PubMed id 16399501)^{1, 2, 9} Gong Y.... Ye J. (2006)
Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER. (PubMed id 12202038)^{1, 2, 9} Yang T.... Brown M.S. (2002)
Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase. (PubMed id 16168377)^{1, 2, 9} Song B.L....DeBose-Boyd R.A. (2005)
The TRC8 ubiquitin ligase is sterol regulated and int eracts with lipid and protein biosynthetic pathways. (PubMed id 20068067)^{1, 2} Lee J.P....Gemmill R.M. (2010)
Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasis. (PubMed id 16606821)^{1, 2} Gong Y.... Ye J. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Membrane topology of human insig-1, a protein regulator of lipid synthesis. (PubMed id 14660594)^{1, 2} Feramisco J.D.... Brown M.S. (2004)
Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain. (PubMed id 12535518)^{1, 2} Sever N.... DeBose-Boyd R.A. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3638	HGNC: 6083	AceView: INSIG1	Ensembl:ENSG00000186480	euGenes: HUgn3638
ECgene: INSIG1	H-InvDB: INSIG1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for INSIG1	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/Insig1

Intellectual Property for INSIG1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for INSIG1 gene:
Search GeneIP for patents involving INSIG1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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