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Aliases for INSC Gene

Aliases for INSC Gene

  • Inscuteable Homolog (Drosophila) 2 3 5
  • Inscuteable Spindle Orientation Adaptor Protein 2

External Ids for INSC Gene

Previous GeneCards Identifiers for INSC Gene

  • GC11P014817

Summaries for INSC Gene

Entrez Gene Summary for INSC Gene

  • In Drosophila, neuroblasts divide asymmetrically into another neuroblast at the apical side and a smaller ganglion mother cell on the basal side. Cell polarization is precisely regulated by 2 apically localized multiprotein signaling complexes that are tethered by Inscuteable, which regulates their apical localization (Izaki et al., 2006 [PubMed 16458856]).[supplied by OMIM, Mar 2008]

GeneCards Summary for INSC Gene

INSC (Inscuteable Homolog (Drosophila)) is a Protein Coding gene. Diseases associated with INSC include optic disk drusen. GO annotations related to this gene include binding.

UniProtKB/Swiss-Prot for INSC Gene

  • May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex (PubMed:16458856). Involved in spindle orientation during mitosis. May regulate cell proliferation and differentiation in the developing nervous system. May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INSC Gene

Genomics for INSC Gene

Regulatory Elements for INSC Gene

Genomic Location for INSC Gene

Chromosome:
11
Start:
15,111,430 bp from pter
End:
15,247,208 bp from pter
Size:
135,779 bases
Orientation:
Plus strand

Genomic View for INSC Gene

Genes around INSC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INSC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INSC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INSC Gene

Proteins for INSC Gene

  • Protein details for INSC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q1MX18-INSC_HUMAN
    Recommended name:
    Protein inscuteable homolog
    Protein Accession:
    Q1MX18
    Secondary Accessions:
    • A0PJX5
    • Q1MX19
    • Q3C1V6
    • Q4AC95
    • Q4AC96
    • Q4AC97
    • Q4AC98

    Protein attributes for INSC Gene

    Size:
    579 amino acids
    Molecular mass:
    63469 Da
    Quaternary structure:
    • Interacts with ALS2CR19/PAR3-beta and F2RL2/PAR3 (PubMed:16458856). Interacts with GPSM1/AGS3 and GPSM2/LGN (via TPR repeat region) (PubMed:16458856, PubMed:22074847). Identified in a complex with GPSM2 and F2RL2 (PubMed:16458856).

    Three dimensional structures from OCA and Proteopedia for INSC Gene

    Alternative splice isoforms for INSC Gene

neXtProt entry for INSC Gene

Proteomics data for INSC Gene at MOPED

Post-translational modifications for INSC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for INSC Gene

Domains & Families for INSC Gene

Protein Domains for INSC Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for INSC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with INSC: view

No data available for Gene Families and UniProtKB/Swiss-Prot for INSC Gene

Function for INSC Gene

Molecular function for INSC Gene

UniProtKB/Swiss-Prot Function:
May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex (PubMed:16458856). Involved in spindle orientation during mitosis. May regulate cell proliferation and differentiation in the developing nervous system. May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium (By similarity).

Phenotypes for INSC Gene

genes like me logo Genes that share phenotypes with INSC: view

Animal Models for INSC Gene

MGI Knock Outs for INSC:

Animal Model Products

miRNA for INSC Gene

miRTarBase miRNAs that target INSC

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for INSC Gene

Localization for INSC Gene

Subcellular locations from UniProtKB/Swiss-Prot for INSC Gene

Cytoplasm. Cytoplasm, cell cortex. Note=Uniformly distributed in the cytoplasm during interphase. During metaphase, detected in the cell cortex, adjacent to the mitotic spindle poles. {ECO:0000269 PubMed:22074847}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for INSC Gene COMPARTMENTS Subcellular localization image for INSC gene
Compartment Confidence
cytosol 2
mitochondrion 2
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for INSC Gene

Pathways & Interactions for INSC Gene

SuperPathways for INSC Gene

No Data Available

Gene Ontology (GO) - Biological Process for INSC Gene

None

No data available for Pathways by source and SIGNOR curated interactions for INSC Gene

Drugs & Compounds for INSC Gene

No Compound Related Data Available

Transcripts for INSC Gene

Unigene Clusters for INSC Gene

Inscuteable homolog (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for INSC Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: -
SP2: - -
SP3: - - -
SP4:

Relevant External Links for INSC Gene

GeneLoc Exon Structure for
INSC
ECgene alternative splicing isoforms for
INSC

Expression for INSC Gene

mRNA expression in normal human tissues for INSC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for INSC Gene

This gene is overexpressed in Nerve - Tibial (x9.9) and Colon - Sigmoid (x4.4).

Protein differential expression in normal tissues from HIPED for INSC Gene

This gene is overexpressed in Gallbladder (34.6), Pancreatic juice (18.4), and Platelet (15.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for INSC Gene



SOURCE GeneReport for Unigene cluster for INSC Gene Hs.591997

mRNA Expression by UniProt/SwissProt for INSC Gene

Q1MX18-INSC_HUMAN
Tissue specificity: Isoform 1 is expressed in various tissues with stronger expression in liver, kidney and small intestine. Isoform 2 is abundantly expressed in small intestine and to a lower extent in lung and pancreas.
genes like me logo Genes that share expression patterns with INSC: view

Protein tissue co-expression partners for INSC Gene

Primer Products

In Situ Assay Products

Orthologs for INSC Gene

This gene was present in the common ancestor of animals.

Orthologs for INSC Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia INSC 35
  • 90.62 (n)
  • 95.68 (a)
INSC 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Insc 35
  • 88.41 (n)
  • 94.36 (a)
Insc 16
Insc 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia INSC 35
  • 99.08 (n)
  • 98.96 (a)
INSC 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Insc 35
  • 87.45 (n)
  • 92.75 (a)
cow
(Bos Taurus)
Mammalia INSC 36
  • 95 (a)
OneToOne
INSC 35
  • 90.79 (n)
  • 95.34 (a)
oppossum
(Monodelphis domestica)
Mammalia INSC 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 82 (a)
OneToMany
-- 36
  • 76 (a)
OneToMany
chicken
(Gallus gallus)
Aves INSC 35
  • 69.3 (n)
  • 74.95 (a)
INSC 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 58 (a)
OneToMany
-- 36
  • 77 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia insc 35
  • 63.96 (n)
  • 58.43 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101885356 35
  • 68.21 (n)
  • 71.92 (a)
INSC 36
  • 45 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea insc-1 36
  • 15 (a)
OneToOne
Species with no ortholog for INSC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for INSC Gene

ENSEMBL:
Gene Tree for INSC (if available)
TreeFam:
Gene Tree for INSC (if available)

Paralogs for INSC Gene

No data available for Paralogs for INSC Gene

Variants for INSC Gene

Sequence variations from dbSNP and Humsavar for INSC Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs7123855 - 15,238,925(+) GGTCC(A/G)GCTTA nc-transcript-variant, reference, missense
rs17507577 - 15,221,513(+) TGACC(A/G)ACAAC nc-transcript-variant, reference, missense
rs870642 -- 15,150,944(-) caggt(A/G)catag intron-variant
rs872172 -- 15,117,742(-) ATTTG(A/G)AATTG intron-variant
rs872689 -- 15,190,355(+) TAACT(A/G)ATGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for INSC Gene

Variant ID Type Subtype PubMed ID
nsv897007 CNV Gain 21882294
nsv897009 CNV Gain 21882294
nsv897010 CNV Gain 21882294
nsv516403 CNV Loss 19592680
nsv832072 CNV Gain 17160897

Variation tolerance for INSC Gene

Residual Variation Intolerance Score: 95% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.82; 79.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for INSC Gene

HapMap Linkage Disequilibrium report
INSC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INSC Gene

Disorders for INSC Gene

MalaCards: The human disease database

(1) MalaCards diseases for INSC Gene - From: DISEASES

Disorder Aliases PubMed IDs
optic disk drusen
  • drusen of optic disc
- elite association - COSMIC cancer census association via MalaCards
Search INSC in MalaCards View complete list of genes associated with diseases

Relevant External Links for INSC

Genetic Association Database (GAD)
INSC
Human Genome Epidemiology (HuGE) Navigator
INSC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
INSC
genes like me logo Genes that share disorders with INSC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for INSC Gene

Publications for INSC Gene

  1. Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3. (PMID: 16458856) Izaki T. … Sumimoto H. (Biochem. Biophys. Res. Commun. 2006) 2 3 4 67
  2. Common variation near ROBO2 is associated with expressive vocabulary in infancy. (PMID: 25226531) St Pourcain B. … Davey Smith G. (Nat Commun 2014) 3
  3. Genome wide association study of age at menarche in the Japanese population. (PMID: 23667675) Tanikawa C. … Matsuda K. (PLoS ONE 2013) 3
  4. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PMID: 22219177) Tao S. … Sun J. (Carcinogenesis 2012) 3
  5. Proteomics strategy to identify substrates of LNX, a PDZ domain-containing E3 ubiquitin ligase. (PMID: 22889411) Guo Z. … Gao Y. (J. Proteome Res. 2012) 3

Products for INSC Gene

Sources for INSC Gene

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