Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



INSC Gene

protein-coding   GIFtS: 50
GCID: GC11P015127

Inscuteable Homolog (Drosophila)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Inscuteable Homolog (Drosophila)1 2
Inscuteable Spindle Orientation Adaptor Protein1 2
Protein Inscuteable Homolog2

External Ids:    HGNC: 331161   Entrez Gene: 3877552   Ensembl: ENSG000001884877   OMIM: 6106685   UniProtKB: Q1MX183   

Export aliases for INSC gene to outside databases

Previous GC identifer: GC11P014817


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for INSC Gene:
In Drosophila, neuroblasts divide asymmetrically into another neuroblast at the apical side and a smaller ganglion
mother cell on the basal side. Cell polarization is precisely regulated by 2 apically localized multiprotein
signaling complexes that are tethered by Inscuteable, which regulates their apical localization (Izaki et al.,
2006 (PubMed 16458856)).(supplied by OMIM, Mar 2008)

GeneCards Summary for INSC Gene:
INSC (inscuteable homolog (Drosophila)) is a protein-coding gene. Diseases associated with INSC include optic disk drusen, and protein c deficiency.

UniProtKB/Swiss-Prot: INSC_HUMAN, Q1MX18
Function: May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex. Involved in spindle
orientation during mitosis it may regulate cell proliferation and differentiation in the developing nervous
system. May play a role in the asymmetric division of fibroblasts and participate in the process of
stratification of the squamous epithelium




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000011.10  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the INSC gene promoter:
         GR   Sox9   GR-alpha   LCR-F1   ATF   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidINSC promoter sequence
   Search Chromatin IP Primers for INSC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat INSC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.2   Ensembl cytogenetic band:  11p15.2   HGNC cytogenetic band: 11p15.2

INSC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INSC gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P015127:  view genomic region     (about GC identifiers)

Start:
15,133,970 bp from pter      End:
15,268,754 bp from pter
Size:
134,785 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: INSC_HUMAN, Q1MX18 (See protein sequence)
Recommended Name: Protein inscuteable homolog  
Size: 579 amino acids; 63469 Da
Subunit: Interacts with ALS2CR19/PAR3-beta, F2RL2/PAR3, GPSM1/AGS3 and GPSM2/LGN
Developmental stage: Expressed in fetal cochlea
1 PDB 3D structure from and Proteopedia for INSC:
3SF4 (3D)    
Secondary accessions: Q1MX19 Q3C1V6 Q4AC95 Q4AC96 Q4AC97 Q4AC98
Alternative splicing: 5 isoforms:  Q1MX18-1   Q1MX18-2   Q1MX18-3   Q1MX18-4   Q1MX18-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for INSC: NX_Q1MX18

Explore proteomics data for INSC at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See INSC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001027024.3  NP_001036001.1  NP_001265242.1  NP_001265243.1  NP_001265244.1  NP_001265245.1  

    ENSEMBL proteins: 
     ENSP00000368872   ENSP00000368874   ENSP00000435022   ENSP00000436194   ENSP00000436113  
     ENSP00000389161  

    INSC Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for INSC
    GenScript Custom Purified and Recombinant Proteins Services for INSC
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for INSC

    INSC Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of INSC
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for INSC
    Novus Biologicals INSC Antibody
    Abcam antibodies for INSC
    Cloud-Clone Corp. Antibodies for INSC
    Search ThermoFisher Antibodies for INSC
    LSBio Antibodies in human, mouse, rat for INSC

    INSC Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for INSC
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for INSC
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for INSC
    Cloud-Clone Corp. CLIAs for INSC


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR011989 ARM-like
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q1MX18

    ProtoNet protein and cluster: Q1MX18


    INSC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: INSC_HUMAN, Q1MX18
    Function: May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex. Involved in spindle
    orientation during mitosis it may regulate cell proliferation and differentiation in the developing nervous
    system. May play a role in the asymmetric division of fibroblasts and participate in the process of
    stratification of the squamous epithelium

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding ----
         
    INSC for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Insc):
     cellular  nervous system 

    INSC for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for INSC
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for INSC

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for INSC
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for INSC

    miRNA
    Products:
        
    miRTarBase miRNAs that target INSC:
    hsa-mir-335-5p (MIRT018388)

    Block miRNA regulation of human, mouse, rat INSC using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate INSC:
    hsa-miR-31 hsa-miR-186 hsa-miR-3613-3p hsa-miR-3133 hsa-miR-570 hsa-miR-1305 hsa-miR-421
    SwitchGear 3'UTR luciferase reporter plasmidINSC 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for INSC
    Predesigned siRNA for gene silencing in human, mouse, rat INSC

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for INSC

    Clone
    Products:
         
    OriGene clones in human, mouse for INSC (see all 13)
    OriGene ORF clones in mouse, rat for INSC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): INSC (NM_001031853)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INSC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INSC

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for INSC
    Browse ESI BIO Cell Lines and PureStem Progenitors for INSC 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INSC


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    INSC_HUMAN, Q1MX18: Cytoplasm. Note=Localizes to the apical cortex of mitotic epidermal cells and to the apical
    side of neuronal progenitor cells (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    cytoskeleton1
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0045177apical part of cell IEA--

    INSC for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for INSC
    Interactions:

        Search GeneGlobe Interaction Network for INSC

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for INSC (Q1MX183 ENSP000003688724) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GPSM2P812743, ENSP000002641264I2D: score=1 STRING: ENSP00000264126
    PARD3Q8TEW03, ENSP000003639214I2D: score=1 STRING: ENSP00000363921
    PARD3BQ8TEW83, ENSP000003516184I2D: score=1 STRING: ENSP00000351618
    GPSM1Q86YR53, ENSP000003928284I2D: score=1 STRING: ENSP00000392828
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000132establishment of mitotic spindle orientation IEA--
    GO:0007399nervous system development IEA--
    GO:0060487lung epithelial cell differentiation IEA--

    INSC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for INSC



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for INSC gene (6 alternative transcripts): 
    NM_001031853.4  NM_001042536.2  NM_001278313.1  NM_001278314.1  NM_001278315.1  NM_001278316.1  

    Unigene Cluster for INSC:

    Inscuteable homolog (Drosophila)
    Hs.591997  [show with all ESTs]
    Unigene Representative Sequence: NM_001031853
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379554(uc001mly.3) ENST00000379556(uc001mlz.3 uc001mma.3 uc010rcs.2 uc001mmb.3 uc001mmc.3)
    ENST00000528567 ENST00000530161 ENST00000525218 ENST00000447214 ENST00000526102
    ENST00000424273
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat INSC using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate INSC:
    hsa-miR-31 hsa-miR-186 hsa-miR-3613-3p hsa-miR-3133 hsa-miR-570 hsa-miR-1305 hsa-miR-421
    SwitchGear 3'UTR luciferase reporter plasmidINSC 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for INSC
    Predesigned siRNA for gene silencing in human, mouse, rat INSC
    Clone
    Products:
         
    OriGene clones in human, mouse for INSC (see all 13)
    OriGene ORF clones in mouse, rat for INSC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): INSC (NM_001031853)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INSC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INSC
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for INSC
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat INSC
      QuantiTect SYBR Green Assays in human, mouse, rat INSC
      QuantiFast Probe-based Assays in human, mouse, rat INSC

    Additional mRNA sequence: 

    AB231744.1 AB231745.1 AB231746.1 AB231747.1 AB231748.1 AB231749.1 AB236158.1 AB236159.1 
    BC117561.1 BC127700.1 

    4 DOTS entries:

    DT.106217  DT.100018701  DT.120694181  DT.95255632 

    23 AceView cDNA sequences:

    BU147420 AI741816 AI453831 BM673403 BQ670968 AW004862 BF064282 BQ675721 
    AI075210 BQ669081 BF432206 BQ009580 AI051065 AA772140 BQ675769 AA888796 
    AA843898 H87971 AI761457 BX105707 AA379047 BI495831 BI495830 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for INSC    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
    SP1:                                                                    -               
    SP2:                    -                                               -               
    SP3:                    -           -                                   -               
    SP4:                                                                                    


    ECgene alternative splicing isoforms for INSC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    INSC expression in normal human tissues (normalized intensities)      INSC embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTATAATAA
    INSC Expression
    About this image


    INSC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)
             Myelinating Oligodendrocyte Cells Forebrain White Matter
    INSC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    INSC Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591997

    UniProtKB/Swiss-Prot: INSC_HUMAN, Q1MX18
    Tissue specificity: Isoform 1 is expressed in various tissues with stronger expression in liver, kidney and small
    intestine. Isoform 2 is abundantly expressed in small intestine and to a lower extent in lung and pancreas

        Custom PCR Arrays for INSC
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for INSC
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat INSC
    QuantiTect SYBR Green Assays in human, mouse, rat INSC
    QuantiFast Probe-based Assays in human, mouse, rat INSC
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INSC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for INSC gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Insc1 , 5 inscuteable homolog (Drosophila)1, 5 88.41(n)1
    94.36(a)1
      7 (60.23 cM)5
    2337521  NM_173767.31  NP_776128.21 
     1147436945 
    chicken
    (Gallus gallus)
    Aves INSC1 inscuteable homolog (Drosophila) 69.3(n)
    74.95(a)
      423067  XM_004941396.1  XP_004941453.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    77(a)
    58(a)
    many → 1
    many → 1
    1(65011660-65042902)
    1(64872869-64965641)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia insc1 inscuteable homolog (Drosophila) 63.96(n)
    58.43(a)
      101731111  XM_004914198.1  XP_004914255.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018853561 protein inscuteable homolog 68.21(n)
    71.92(a)
      101885356  XM_005174077.1  XP_005174134.1 
    worm
    (Caenorhabditis elegans)
    Secernentea insc-16
    Protein INSC-1 (insc-1) mRNA, complete cds
    15(a)
    1 ↔ 1
    II(7359961-7363245) WBGene00018392


    ENSEMBL Gene Tree for INSC (if available)
    TreeFam Gene Tree for INSC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for INSC (see all 2919)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1822417981,2
    --15132027(+) GGAACA/TTTTTA 1 -- us2k10--------
    rs343822421,2
    C,F--15132050(+) CTTCAG/ACTCAG 1 -- us2k14Minor allele frequency- A:0.08NA 126
    rs1874397211,2
    --15132220(+) GACAAC/TAGAAA 1 -- us2k10--------
    rs1889586081,2
    --15132234(+) TTGGGA/GAATTC 1 -- us2k10--------
    rs1816075061,2
    --15132417(+) CTGGCA/GGACTG 1 -- us2k10--------
    rs1416421261,2
    --15132443(+) TCCTGC/TATGTC 1 -- us2k10--------
    rs1855389111,2
    --15132531(+) GGCCAA/GTAAGC 1 -- us2k10--------
    rs110234381,2
    --15132588(+) CTGGCC/GCCAAT 1 -- us2k10--------
    rs107342311,2
    C,F,H--15132593(+) CCCAAC/TCCCTG 1 -- us2k118Minor allele frequency- T:0.02NS NA WA CSA EA 1165
    rs1481425931,2
    --15132600(+) CCTGTC/TTCCTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for INSC (15133970 - 15268754 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for INSC:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv516403CNV Loss19592680
    nsv897007CNV Gain21882294
    nsv832072CNV Gain17160897
    nsv897010CNV Gain21882294
    nsv897009CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing INSC
    DNA2.0 Custom Variant and Variant Library Synthesis for INSC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 610668    OMIM disorders: --

    6 diseases for INSC:    About MalaCards
    optic disk drusen    protein c deficiency    obesity    prostate cancer
    neuronitis    prostatitis

    1 disease from the University of Copenhagen DISEASES database for INSC:
    Optic disk drusen

    INSC for disorders           About GeneDecksing

    Genetic Association Database (GAD): INSC
    Human Genome Epidemiology (HuGE) Navigator: INSC (6 documents)

    Export disorders for INSC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for INSC gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with INSC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3. (PubMed id 16458856)1, 2, 3 Izaki T.... Sumimoto H. (Biochem. Biophys. Res. Commun. 2006)
    2. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PubMed id 22219177)1, 4 Tao S....Sun J. (Carcinogenesis 2012)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Identification and characterization of human Inscuteable gene in silico. (PubMed id 12469229)1, 2 Katoh M. and Katoh M. (Int. J. Mol. Med. 2003)
    5. Genome wide association study of age at menarche in the Japanese population. (PubMed id 23667675)1 Tanikawa C....Matsuda K. (PLoS ONE 2013)
    6. On the inscrutable role of Inscuteable: structural basis and functional implications for the competitive binding of NuMA and Inscuteable to LGN. (PubMed id 22977735)1 Mapelli M. and Gonzalez C. (Open Biol 2012)
    7. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    8. Proteomics strategy to identify substrates of LNX, a PDZ domain-containing E3 ubiquitin ligase. (PubMed id 22889411)1 Guo Z....Gao Y. (J. Proteome Res. 2012)
    9. Structural basis for interaction between the conserved cell polarity proteins Inscuteable and Leu-Gly-Asn repeat-enriched protein (LGN). (PubMed id 22074847)1 Yuzawa S....Sumimoto H. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    10. Distribution of activator of G-protein signaling 3 within the aggresomal pathway: role of specific residues in the tetratricopeptide repeat domain and differential regulation by the AGS3 binding partners Gi(alpha) and mammalian inscuteable. (PubMed id 20065032)1 Vural A....Lanier S.M. (Mol. Cell. Biol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 387755 HGNC: 33116 AceView: LOC387755 Ensembl:ENSG00000188487 euGenes: HUgn387755
    ECgene: INSC H-InvDB: INSC

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for INSC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for INSC gene:
    Search GeneIP for patents involving INSC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of INSC
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for INSC  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for INSC  
     OriGene qSTAR qPCR primer pairs in human, mouse for INSC   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for INSC   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for INSC   OriGene Custom Protein Services for INSC  

     
     
     Block miRNA regulation of human, mouse, rat INSC using miScript Target Protectors SeqTarget long-range PCR primers for resequencing INSC
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat INSC Predesigned siRNA for gene silencing in human, mouse, rat INSC
     QuantiFast Probe-based Assays in human, mouse, rat INSC QuantiTect SYBR Green Assays in human, mouse, rat INSC
     Custom PCR Arrays for INSC Search Chromatin IP Primers for INSC
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat INSC  Search GeneGlobe Interaction Network for INSC
     Regulatory tfbs in INSC promoter
     GenScript Custom Purified and Recombinant Proteins Services for INSC GenScript cDNA clones with any tag delivered in your preferred vector for INSC
     GenScript Custom Assay Services for INSC GenScript Custom overexpressing Cell Line Services for INSC
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for INSC
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     INSC antibodies
     Antibodies for INSC
     See all of Abcam's Antibodies, Kits and Proteins for INSC
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for INSC
     Antibodies for INSC
     ELISAs for INSC
     CLIAs for INSC



     Browse ESI BIO Cell Lines and PureStem Progenitors for INSC
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INSC
     SwitchGear 3'UTR luciferase reporter plasmids for INSC
     SwitchGear Promoter luciferase reporter plasmids for INSC
     Search ThermoFisher Antibodies for INSC
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INSC
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for INSC
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for INSC
     LSBio Antibodies in human, mouse, rat for INSC
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      INSC gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4