Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

INSC Gene

protein-coding   GIFtS: 49
GCID: GC11P015127

inscuteable homolog (Drosophila)
 Explore 3 diseases affiliated with
INSC via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for INSC    

Aliases
for INSC gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Inscuteable Homolog (Drosophila)1 2
Protein Inscuteable Homolog2

External Ids:    HGNC: 331161   Entrez Gene: 3877552   Ensembl: ENSG000001884877   OMIM: 6106685   UniProtKB: Q1MX183   

Export aliases for INSC gene to outside databases

Previous GC identifer: GC11P014817


Summaries
for INSC gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for INSC:
In Drosophila, neuroblasts divide asymmetrically into another neuroblast at the apical side and a smaller ganglion
mother cell on the basal side. Cell polarization is precisely regulated by 2 apically localized multiprotein signaling
complexes that are tethered by Inscuteable, which regulates their apical localization (Izaki et al., 2006 (PubMed
16458856)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: INSC_HUMAN, Q1MX18
Function: May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex. Involved in spindle
orientation during mitosis it may regulate cell proliferation and differentiation in the developing nervous system.
May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the
squamous epithelium




Genomic Views
for INSC gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the INSC gene promoter:
         GR   Sox9   GR-alpha   LCR-F1   ATF   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: INSC promoter sequence
   Search SABiosciences Chromatin IP Primers for INSC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INSC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.2   Ensembl cytogenetic band:  11p15.2   HGNC cytogenetic band: 11p15.2

INSC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INSC gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P015127:  view genomic region     (about GC identifiers)

Start:
 15,133,970 bp from pter      End:
 15,268,754 bp from pter
Size:
 134,785 bases      Orientation:
 plus strand

Proteins
for INSC gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: INSC_HUMAN, Q1MX18 (See protein sequence)
Recommended Name: Protein inscuteable homolog  
Size: 579 amino acids; 63469 Da
Subunit: Interacts with ALS2CR19/PAR3-beta, F2RL2/PAR3, GPSM1/AGS3 and GPSM2/LGN
Subcellular location: Cytoplasm. Note=Localizes to the apical cortex of mitotic epidermal cells and to the apical side
of neuronal progenitor cells (By similarity)
Developmental stage: Expressed in fetal cochlea
1 PDB 3D structure from and Proteopedia for INSC:
3SF4 (3D)    
Secondary accessions: Q1MX19 Q3C1V6 Q4AC95 Q4AC96 Q4AC97 Q4AC98
Alternative splicing: 5 isoforms:  Q1MX18-1   Q1MX18-2   Q1MX18-3   Q1MX18-4   Q1MX18-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for INSC: NX_Q1MX18

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q1MX18

    • INSC Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001027024.3  NP_001036001.1  

    ENSEMBL proteins: 
     ENSP00000368872   ENSP00000368874   ENSP00000435022   ENSP00000436194   ENSP00000436113  
     ENSP00000389161  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for INSC 
    GenScript Custom Purified and Recombinant Proteins Services for INSC
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for INSC

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0045177apical part of cell IEA--


    INSC for ontologies           About GeneDecksing



    INSC Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of INSC
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for INSC 
    GenScript Custom Superior Antibodies Services for INSC
    Novus Biologicals INSC Antibody
    Search for Antibodies for INSC at Abcam  
    Uscn Antibodies for INSC
    ThermoFisher Antibodies for INSC

    Assay Products for INSC: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for INSC
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for INSC

    Protein Domains /
    Families
    for INSC gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    INSC for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR011989 ARM-like
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q1MX18

    ProtoNet protein and cluster: Q1MX18


    Function
    for INSC gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: INSC_HUMAN, Q1MX18
    Function: May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex. Involved in spindle
    orientation during mitosis it may regulate cell proliferation and differentiation in the developing nervous system.
    May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the
    squamous epithelium

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): INSC
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat INSC
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate INSC:
    hsa-miR-31 hsa-miR-186 hsa-miR-3613-3p hsa-miR-3133 hsa-miR-570 hsa-miR-1305 hsa-miR-421
    SwitchGear 3'UTR luciferase reporter plasmid: INSC 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for INSC (see all 7)
    OriGene shRNA RFP: INSC
    OriGene siRNA: INSC
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat INSC

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for INSC

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for INSC (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for INSC (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): INSC (NM_001031853)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INSC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INSC 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for INSC
    Search LifeMap BioReagents cell lines for INSC

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INSC

    Animal Models:
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Insc):
     cellular  nervous system 

    INSC for phenotypes           About GeneDecksing


    Pathways & Interactions
    for INSC gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for INSC

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for INSC (Q1MX183 ENSP000003688724) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GPSM2P812743, ENSP000002641264I2D: score=1 STRING: ENSP00000264126
    PARD3Q8TEW03, ENSP000003639214I2D: score=1 STRING: ENSP00000363921
    PARD3BQ8TEW83, ENSP000003516184I2D: score=1 STRING: ENSP00000351618
    GPSM1Q86YR53, ENSP000003928284I2D: score=1 STRING: ENSP00000392828
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000132establishment of mitotic spindle orientation IEA--
    GO:0007399nervous system development IEA--
    GO:0060487lung epithelial cell differentiation IEA--


    INSC for ontologies           About GeneDecksing



    Drugs & Compounds
    for INSC gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for INSC
    Search CenterWatch for drugs/clinical trials and news about INSC 

    Transcripts
    for INSC gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for INSC gene (2 alternative transcripts): 
    NM_001031853.3  NM_001042536.1  

    Unigene Cluster for INSC:

    Inscuteable homolog (Drosophila)
    Hs.591997  [show with all ESTs]
    Unigene Representative Sequence: NM_001031853
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379554(uc001mly.3) ENST00000379556(uc001mlz.3 uc001mma.3 uc010rcs.2 uc001mmb.3 uc001mmc.3)
    ENST00000528567 ENST00000530161 ENST00000525218 ENST00000447214 ENST00000526102
    ENST00000424273

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): INSC
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat INSC
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate INSC:
    hsa-miR-31 hsa-miR-186 hsa-miR-3613-3p hsa-miR-3133 hsa-miR-570 hsa-miR-1305 hsa-miR-421
    SwitchGear 3'UTR luciferase reporter plasmid: INSC 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for INSC (see all 7)
    OriGene shRNA RFP: INSC
    OriGene siRNA: INSC
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat INSC
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for INSC (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for INSC (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): INSC (NM_001031853)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INSC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INSC 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for INSC
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat INSC
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INSC
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INSC

    Additional cDNA sequence: 

    AB231744.1 AB231745.1 AB231746.1 AB231747.1 AB231748.1 AB231749.1 AB236158.1 AB236159.1 
    BC117561.1 BC127700.1 

    4 DOTS entries:

    DT.106217  DT.100018701  DT.120694181  DT.95255632 

    23 AceView cDNA sequences:

    BU147420 BQ669081 AI075210 BF064282 BQ675769 AI051065 BQ670968 AA772140 
    AW004862 BM673403 AI453831 BF432206 BQ675721 AI741816 BQ009580 AA379047 
    BI495831 AA843898 H87971 AA888796 BX105707 AI761457 BI495830 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for INSC    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
    SP1:                                                                    -               
    SP2:                    -                                               -               
    SP3:                    -           -                                   -               
    SP4:                                                                                    


    ECgene alternative splicing isoforms for INSC

    Expression
    for INSC gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    INSC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATTATAATAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    INSC expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor W8 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See INSC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for INSC

    SOURCE GeneReport for Unigene cluster: Hs.591997

    UniProtKB/Swiss-Prot: INSC_HUMAN, Q1MX18
    Tissue specificity: Isoform 1 is expressed in various tissues with stronger expression in liver, kidney and small
    intestine. Isoform 2 is abundantly expressed in small intestine and to a lower extent in lung and pancreas

        SABiosciences Custom PCR Arrays for INSC
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for INSC
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat INSC
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INSC
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INSC
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INSC

    Orthologs
    for INSC gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for INSC gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Insc1 , 5 inscuteable homolog (Drosophila)1, 5 88.35(n)1
    94.36(a)1    		   7 (60.23 cM)5
    2337521  NM_173767.31  NP_776128.21 
     1147436945 
    chicken
    (Gallus gallus)    		 Aves INSC1 inscuteable homolog (Drosophila) 69.72(n)
    75.44(a)    		   423067  XM_420999.3  XP_420999.3 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 77(a)
    55(a)
    		 many → 1
    many → 1
    		 1(65011660-65042901)
    1(64964506-64965641)
    zebrafish
    (Danio rerio)    		 Actinopterygii CABZ01064327.16
    CABZ01092148.16
    		 --
    		 70(a)
    46(a)
    		 many → 1
    many → 1
    		 22(42208356-42209062)
    24(419484-421024)
    fruit fly
    (Drosophila melanogaster)    		 Insecta insc6
    		 inscuteable
    		 12(a)
    		 1 ↔ 1
    		 2R(16708771-16723569)
    worm
    (Caenorhabditis elegans)    		 Secernentea insc-16
    		 INSCuteable (Drosphila asymmetric cell division pr...
    		 17(a)
    		 1 ↔ 1
    		 II(7359918-7363202)


    ENSEMBL Gene Tree for INSC (if available)
    TreeFam Gene Tree for INSC (if available) 

    Paralogs
    for INSC gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for INSC gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2553 NCBI SNPs in INSC are shown (see all 2553)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1822417981,2
    		--15132027(+) GGAACA/TTTTTA 1 -- us2k10--------
    rs343822421,2
    		C,F,--15132050(+) NNNNAG/ACTCAG 1 -- us2k14Minor allele frequency- A:0.08NA 126
    rs1874397211,2
    		--15132220(+) GACAAC/TAGAAA 1 -- us2k10--------
    rs1889586081,2
    		--15132234(+) TTGGGA/GAATTC 1 -- us2k10--------
    rs1816075061,2
    		--15132417(+) CTGGCA/GGACTG 1 -- us2k10--------
    rs1416421261,2
    		--15132443(+) TCCTGC/TATGTC 1 -- us2k10--------
    rs1855389111,2
    		--15132531(+) GGCCAA/GTAAGC 1 -- us2k10--------
    rs110234381,2
    		--15132588(+) CTGGCC/GCCAAT 1 -- us2k10--------
    rs107342311,2
    		C,F,H,--15132593(+) CCCAAC/TCCCTG 1 -- us2k118Minor allele frequency- T:0.02NS NA WA CSA EA 1165
    rs1481425931,2
    		--15132600(+) CCTGTC/TTCCTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for INSC (15133970 - 15268754 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for INSC
         1 CNV: 48751

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing INSC
    DNA2.0 Custom Variant and Variant Library Synthesis for INSC

    Disorders / Diseases
    for INSC gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    INSC for disorders           About GeneDecksing

    OMIM gene information: 610668    OMIM disorders: --

    3 diseases for INSC:    About MalaCards
    optic disk drusen    protein c deficiency    neuronitis

    1 disease from the University of Copenhagen DISEASES database for INSC:
    Optic disk drusen
    Human Genome Epidemiology (HuGE) Navigator: INSC (6 documents)

    Export disorders for INSC gene to outside databases

    Publications
    for INSC gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for INSC gene integrated from 9 sources:
    (articles sorted by number of sources associating them with INSC)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3. (PubMed id 16458856)1, 2, 3 Izaki T.... Sumimoto H. (2006)
    2. Identification and characterization of human Inscuteable gene in silico. (PubMed id 12469229)1, 2 Katoh M. and Katoh M. (2003)
    3. A genome-wide search for loci interacting with known p rostate cancer risk-associated genetic variants. (PubMed id 22219177)1 Tao S....Sun J. (2012)
    4. Proteomics strategy to identify substrates of LNX, a P DZ domain-containing E3 ubiquitin ligase. (PubMed id 22889411)1 Guo Z....Gao Y. (2012)
    5. Structural basis for interaction between the conserve d cell polarity proteins Inscuteable and Leu-Gly-Asn repeat-enriched protein (L GN). (PubMed id 22074847)1 Yuzawa S....Sumimoto H. (2011)
    6. Distribution of activator of G-protein signaling 3 wi thin the aggresomal pathway: role of specific residues in the tetratricopeptide repeat domain and differential regulation by the AGS3 binding partners Gi(alph a) and mammalian inscuteable. (PubMed id 20065032)1 Vural A....Lanier S.M. (2010)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for INSC gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing INSC gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 387755 HGNC: 33116 AceView: LOC387755 Ensembl:ENSG00000188487 euGenes: HUgn387755
    ECgene: INSC H-InvDB: INSC

    Other Databases showing INSC gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing INSC gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for INSC Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for INSC gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for INSC gene:
    Search GeneIP for patents involving INSC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for INSC gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of INSC
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for INSC  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for INSC   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for INSC  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for INSC   OriGene 3'-UTR Clone for INSC  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for INSC   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for INSC  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for INSC   OriGene Custom Protein Services for INSC  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat INSC
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing INSC
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INSC
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat INSC
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INSC
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INSC
     GenScript Custom Purified and Recombinant Proteins Services for INSC GenScript cDNA clones with any tag delivered in your preferred vector for INSC
     GenScript Custom Assay Services for INSC GenScript Custom Superior Antibodies Services for INSC
     GenScript Custom overexpressing Cell Line Services for INSC CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in INSC promoter
     Search Chromatin IP Primers for INSC
     RT2 qPCR Primer Assay in human, mouse, rat INSC
     Search GNC Networks for INSC
     SABiosciences Custom PCR Arrays for INSC
     Search Tocris compounds for INSC
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     INSC antibodies
     Search for Antibodies for INSC at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for INSC
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     INSC Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for INSC
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INSC
     SwitchGear 3'UTR luciferase reporter plasmids for INSC
     SwitchGear Promoter luciferase reporter plasmids for INSC
     ThermoFisher Antibodies for INSC
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INSC
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      INSC gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4