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Aliases for INSC Gene

Aliases for INSC Gene

  • Inscuteable Homolog (Drosophila) 2 3
  • Inscuteable Spindle Orientation Adaptor Protein 2

External Ids for INSC Gene

Summaries for INSC Gene

Entrez Gene Summary for INSC Gene

  • In Drosophila, neuroblasts divide asymmetrically into another neuroblast at the apical side and a smaller ganglion mother cell on the basal side. Cell polarization is precisely regulated by 2 apically localized multiprotein signaling complexes that are tethered by Inscuteable, which regulates their apical localization (Izaki et al., 2006 [PubMed 16458856]).[supplied by OMIM, Mar 2008]

GeneCards Summary for INSC Gene

INSC (Inscuteable Homolog (Drosophila)) is a Protein Coding gene. Diseases associated with INSC include optic disk drusen.

UniProtKB/Swiss-Prot for INSC Gene

  • May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex. Involved in spindle orientation during mitosis it may regulate cell proliferation and differentiation in the developing nervous system. May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INSC Gene

Genomics for INSC Gene

Genomic Location for INSC Gene

Start:
15,112,424 bp from pter
End:
15,247,208 bp from pter
Size:
134,785 bases
Orientation:
Plus strand

Genomic View for INSC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for INSC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INSC Gene

Regulatory Elements for INSC Gene

Proteins for INSC Gene

  • Protein details for INSC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q1MX18-INSC_HUMAN
    Recommended name:
    Protein inscuteable homolog
    Protein Accession:
    Q1MX18
    Secondary Accessions:
    • A0PJX5
    • Q1MX19
    • Q3C1V6
    • Q4AC95
    • Q4AC96
    • Q4AC97
    • Q4AC98

    Protein attributes for INSC Gene

    Size:
    579 amino acids
    Molecular mass:
    63469 Da
    Quaternary structure:
    • Interacts with ALS2CR19/PAR3-beta, F2RL2/PAR3, GPSM1/AGS3 and GPSM2/LGN.

    Three dimensional structures from OCA and Proteopedia for INSC Gene

    Alternative splice isoforms for INSC Gene

neXtProt entry for INSC Gene

Proteomics data for INSC Gene at MOPED

Post-translational modifications for INSC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for INSC Gene

Domains for INSC Gene

Protein Domains for INSC Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with INSC: view

No data available for Gene Families and UniProtKB/Swiss-Prot for INSC Gene

Function for INSC Gene

Molecular function for INSC Gene

UniProtKB/Swiss-Prot Function: May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex. Involved in spindle orientation during mitosis it may regulate cell proliferation and differentiation in the developing nervous system. May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium.

Gene Ontology (GO) - Molecular Function for INSC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with INSC: view

Phenotypes for INSC Gene

genes like me logo Genes that share phenotypes with INSC: view

miRNA for INSC Gene

miRTarBase miRNAs that target INSC

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for INSC Gene

Localization for INSC Gene

Subcellular locations from UniProtKB/Swiss-Prot for INSC Gene

Cytoplasm. Note=Localizes to the apical cortex of mitotic epidermal cells and to the apical side of neuronal progenitor cells. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for INSC Gene COMPARTMENTS Subcellular localization image for INSC gene
Compartment Confidence
cytosol 2
cytoskeleton 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for INSC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0045177 apical part of cell IEA --
genes like me logo Genes that share ontologies with INSC: view

Pathways for INSC Gene

SuperPathways for INSC Gene

No Data Available

Gene Ontology (GO) - Biological Process for INSC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000132 establishment of mitotic spindle orientation IEA --
GO:0007399 nervous system development IEA --
GO:0060487 lung epithelial cell differentiation IEA --
genes like me logo Genes that share ontologies with INSC: view

No data available for Pathways by source for INSC Gene

Transcripts for INSC Gene

Unigene Clusters for INSC Gene

Inscuteable homolog (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for INSC Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: -
SP2: - -
SP3: - - -
SP4:

Relevant External Links for INSC Gene

GeneLoc Exon Structure for
INSC
ECgene alternative splicing isoforms for
INSC

Expression for INSC Gene

mRNA expression in normal human tissues for INSC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for INSC Gene

This gene is overexpressed in Nerve - Tibial (9.9) and Colon - Sigmoid (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for INSC Gene

SOURCE GeneReport for Unigene cluster for INSC Gene Hs.591997

mRNA Expression by UniProt/SwissProt for INSC Gene

Q1MX18-INSC_HUMAN
Tissue specificity: Isoform 1 is expressed in various tissues with stronger expression in liver, kidney and small intestine. Isoform 2 is abundantly expressed in small intestine and to a lower extent in lung and pancreas.
genes like me logo Genes that share expressions with INSC: view

Orthologs for INSC Gene

This gene was present in the common ancestor of animals.

Orthologs for INSC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INSC 36
  • 99.08 (n)
  • 98.96 (a)
INSC 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia INSC 36
  • 90.79 (n)
  • 95.34 (a)
INSC 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia INSC 36
  • 90.62 (n)
  • 95.68 (a)
INSC 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Insc 36
  • 88.41 (n)
  • 94.36 (a)
Insc 16
Insc 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia INSC 37
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 82 (a)
OneToMany
-- 37
  • 76 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Insc 36
  • 87.45 (n)
  • 92.75 (a)
chicken
(Gallus gallus)
Aves INSC 36
  • 69.3 (n)
  • 74.95 (a)
INSC 37
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 58 (a)
OneToMany
-- 37
  • 77 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia insc 36
  • 63.96 (n)
  • 58.43 (a)
zebrafish
(Danio rerio)
Actinopterygii INSC 37
  • 45 (a)
OneToOne
LOC101885356 36
  • 68.21 (n)
  • 71.92 (a)
worm
(Caenorhabditis elegans)
Secernentea insc-1 37
  • 15 (a)
OneToOne
Species with no ortholog for INSC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for INSC Gene

ENSEMBL:
Gene Tree for INSC (if available)
TreeFam:
Gene Tree for INSC (if available)

Paralogs for INSC Gene

No data available for Paralogs for INSC Gene

Variants for INSC Gene

Sequence variations from dbSNP and Humsavar for INSC Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs870642 -- 15,150,944(-) caggt(A/G)catag intron-variant
rs872172 -- 15,117,742(-) ATTTG(A/G)AATTG intron-variant
rs872689 -- 15,190,355(+) TAACT(A/G)ATGGT intron-variant
rs939048 -- 15,217,808(+) CATTA(A/G)GAAGT intron-variant
rs939049 -- 15,218,054(+) ctggc(A/G)gatgt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for INSC Gene

Variant ID Type Subtype PubMed ID
nsv897007 CNV Gain 21882294
nsv897009 CNV Gain 21882294
nsv897010 CNV Gain 21882294
nsv516403 CNV Loss 19592680
nsv832072 CNV Gain 17160897

Relevant External Links for INSC Gene

HapMap Linkage Disequilibrium report
INSC

Disorders for INSC Gene

(1) MalaCards Diseases for INSC Gene

Search for INSC Gene in MalaCards »

(1) University of Copenhagen DISEASES for INSC Gene

Relevant External Links for INSC

Genetic Association Database (GAD)
INSC
Human Genome Epidemiology (HuGE) Navigator
INSC
genes like me logo Genes that share disorders with INSC: view

No data available for UniProtKB/Swiss-Prot for INSC Gene

Publications for INSC Gene

  1. Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3. (PMID: 16458856) Izaki T. … Sumimoto H. (Biochem. Biophys. Res. Commun. 2006) 2 3 4
  2. Identification and characterization of human Inscuteable gene in silico. (PMID: 12469229) Katoh M. … Katoh M. (Int. J. Mol. Med. 2003) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  4. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PMID: 22219177) Tao S. … Sun J. (Carcinogenesis 2012) 3 49
  5. Proteomics strategy to identify substrates of LNX, a PDZ domain-containing E3 ubiquitin ligase. (PMID: 22889411) Guo Z. … Gao Y. (J. Proteome Res. 2012) 3

Products for INSC Gene

Sources for INSC Gene

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