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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

INSC Gene

protein-coding   GIFtS: 48
GCID: GC11P015127

Inscuteable Homolog (Drosophila)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Inscuteable Homolog (Drosophila)1 2
Protein Inscuteable Homolog2

External Ids:    HGNC: 331161   Entrez Gene: 3877552   Ensembl: ENSG000001884877   OMIM: 6106685   UniProtKB: Q1MX183   

Export aliases for INSC gene to outside databases

Previous GC identifer: GC11P014817


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for INSC Gene:
In Drosophila, neuroblasts divide asymmetrically into another neuroblast at the apical side and a smaller ganglion
mother cell on the basal side. Cell polarization is precisely regulated by 2 apically localized multiprotein
signaling complexes that are tethered by Inscuteable, which regulates their apical localization (Izaki et al.,
2006 (PubMed 16458856)).(supplied by OMIM, Mar 2008)

GeneCards Summary for INSC Gene: 
INSC (inscuteable homolog (Drosophila)) is a protein-coding gene. Diseases associated with INSC include optic disk drusen, and protein c deficiency.

UniProtKB/Swiss-Prot: INSC_HUMAN, Q1MX18
Function: May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex. Involved in spindle
orientation during mitosis it may regulate cell proliferation and differentiation in the developing nervous
system. May play a role in the asymmetric division of fibroblasts and participate in the process of
stratification of the squamous epithelium




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_009237.18  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the INSC gene promoter:
         GR   Sox9   GR-alpha   LCR-F1   ATF   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidINSC promoter sequence
   Search SABiosciences Chromatin IP Primers for INSC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INSC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.2   Ensembl cytogenetic band:  11p15.2   HGNC cytogenetic band: 11p15.2

INSC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INSC gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P015127:  view genomic region     (about GC identifiers)

Start:
15,133,970 bp from pter      End:
15,268,754 bp from pter
Size:
134,785 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: INSC_HUMAN, Q1MX18 (See protein sequence)
Recommended Name: Protein inscuteable homolog  
Size: 579 amino acids; 63469 Da
Subunit: Interacts with ALS2CR19/PAR3-beta, F2RL2/PAR3, GPSM1/AGS3 and GPSM2/LGN
Subcellular location: Cytoplasm. Note=Localizes to the apical cortex of mitotic epidermal cells and to the apical
side of neuronal progenitor cells (By similarity)
Developmental stage: Expressed in fetal cochlea
1 PDB 3D structure from and Proteopedia for INSC:
3SF4 (3D)    
Secondary accessions: Q1MX19 Q3C1V6 Q4AC95 Q4AC96 Q4AC97 Q4AC98
Alternative splicing: 5 isoforms:  Q1MX18-1   Q1MX18-2   Q1MX18-3   Q1MX18-4   Q1MX18-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for INSC: NX_Q1MX18

Explore proteomics data for INSC at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q1MX18

  • INSC Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    INSC Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001027024.3  NP_001036001.1  NP_001265242.1  NP_001265243.1  NP_001265244.1  NP_001265245.1  

    ENSEMBL proteins: 
     ENSP00000368872   ENSP00000368874   ENSP00000435022   ENSP00000436194   ENSP00000436113  
     ENSP00000389161  

    Human Recombinant Protein Products for INSC: 
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    Cloud-Clone Corp. Proteins for INSC 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0045177apical part of cell IEA--

    INSC for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for INSC


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR011989 ARM-like
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q1MX18

    ProtoNet protein and cluster: Q1MX18


    INSC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: INSC_HUMAN, Q1MX18
    Function: May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex. Involved in spindle
    orientation during mitosis it may regulate cell proliferation and differentiation in the developing nervous
    system. May play a role in the asymmetric division of fibroblasts and participate in the process of
    stratification of the squamous epithelium

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding ----
         
    INSC for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Insc):
     cellular  nervous system 

    INSC for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for INSC 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for INSC

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for INSC 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for INSC 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat INSC
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate INSC:
    hsa-miR-31 hsa-miR-186 hsa-miR-3613-3p hsa-miR-3133 hsa-miR-570 hsa-miR-1305 hsa-miR-421
    SwitchGear 3'UTR luciferase reporter plasmidINSC 3' UTR sequence
    Inhib. RNA
    Products:
        
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    GenScript: all cDNA clones in your preferred vector (see all 2): INSC (NM_001031853)
    Browse Sino Biological Human cDNA Clones
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                         Customized lentivirus expression plasmids for stable overexpression of INSC 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INSC


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for INSC

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for INSC (Q1MX183 ENSP000003688724) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GPSM2P812743, ENSP000002641264I2D: score=1 STRING: ENSP00000264126
    PARD3Q8TEW03, ENSP000003639214I2D: score=1 STRING: ENSP00000363921
    PARD3BQ8TEW83, ENSP000003516184I2D: score=1 STRING: ENSP00000351618
    GPSM1Q86YR53, ENSP000003928284I2D: score=1 STRING: ENSP00000392828
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000132establishment of mitotic spindle orientation IEA--
    GO:0007399nervous system development IEA--
    GO:0060487lung epithelial cell differentiation IEA--

    INSC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for INSC

    Search CenterWatch for drugs/clinical trials and news about INSC

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for INSC gene (6 alternative transcripts): 
    NM_001031853.4  NM_001042536.2  NM_001278313.1  NM_001278314.1  NM_001278315.1  NM_001278316.1  

    Unigene Cluster for INSC:

    Inscuteable homolog (Drosophila)
    Hs.591997  [show with all ESTs]
    Unigene Representative Sequence: NM_001031853
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379554(uc001mly.3) ENST00000379556(uc001mlz.3 uc001mma.3 uc010rcs.2 uc001mmb.3 uc001mmc.3)
    ENST00000528567 ENST00000530161 ENST00000525218 ENST00000447214 ENST00000526102
    ENST00000424273
    miRNA
    Products:
         
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate INSC:
    hsa-miR-31 hsa-miR-186 hsa-miR-3613-3p hsa-miR-3133 hsa-miR-570 hsa-miR-1305 hsa-miR-421
    SwitchGear 3'UTR luciferase reporter plasmidINSC 3' UTR sequence
    Inhib. RNA
    Products:
         
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    OriGene RNAi products in human, mouse, rat for INSC
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INSC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INSC
    Sirion Biotech Customized lentivirus for stable overexpression of INSC 
                         Customized lentivirus expression plasmids for stable overexpression of INSC 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for INSC
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INSC
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INSC

    Additional mRNA sequence: 

    AB231744.1 AB231745.1 AB231746.1 AB231747.1 AB231748.1 AB231749.1 AB236158.1 AB236159.1 
    BC117561.1 BC127700.1 

    4 DOTS entries:

    DT.106217  DT.100018701  DT.120694181  DT.95255632 

    23 AceView cDNA sequences:

    BU147420 BQ675721 AI051065 BF432206 BQ009580 AA772140 AI075210 BQ669081 
    BQ670968 AI741816 AI453831 AW004862 BM673403 BF064282 BQ675769 H87971 
    AA379047 AA888796 BI495831 AI761457 AA843898 BX105707 BI495830 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for INSC    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
    SP1:                                                                    -               
    SP2:                    -                                               -               
    SP3:                    -           -                                   -               
    SP4:                                                                                    


    ECgene alternative splicing isoforms for INSC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    INSC expression in normal human tissues (normalized intensities)      INSC embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTATAATAA
    INSC Expression
    About this image


    INSC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Fibroblast
             Human Gingival Fibroblasts (HGF)   
     
     Peripheral Nervous System (Nervous System)
             dorsal root ganglia   
     
     Adipose (Muscoskeletal System)
             Human Preadipocyte-subcutaneous (HPA-s)   
     
     Skeletal Muscle (Muscoskeletal System)
             Human Skeletal Muscle Myoblast (HSkMM)   
     
     Brain (Nervous System)
             Myelinating Oligodendrocyte Cells Forebrain White Matter

    See INSC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for INSC

    SOURCE GeneReport for Unigene cluster: Hs.591997

    UniProtKB/Swiss-Prot: INSC_HUMAN, Q1MX18
    Tissue specificity: Isoform 1 is expressed in various tissues with stronger expression in liver, kidney and small
    intestine. Isoform 2 is abundantly expressed in small intestine and to a lower extent in lung and pancreas

        SABiosciences Custom PCR Arrays for INSC
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INSC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for INSC gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Insc1 , 5 inscuteable homolog (Drosophila)1, 5 88.35(n)1
    94.36(a)1
      7 (60.23 cM)5
    2337521  NM_173767.31  NP_776128.21 
     1147436945 
    chicken
    (Gallus gallus)
    Aves INSC1 inscuteable homolog (Drosophila) 69.72(n)
    75.44(a)
      423067  XM_420999.3  XP_420999.3 
    lizard
    (Anolis carolinensis)
    Reptilia INSC6
    --
    Uncharacterized protein
    77(a)
    57(a)
    many → 1
    many → 1
    1(65011660-65042902)
    1(64872869-64965641)
    zebrafish
    (Danio rerio)
    Actinopterygii CABZ01064327.16
    INSC (1 of 2)6
    inscuteable homolog (Drosophila)
    70(a)
    46(a)
    many → 1
    many → 1
    22(42208356-42209062)
    24(419484-421024)
    fruit fly
    (Drosophila melanogaster)
    Insecta insc6
    inscuteable
    12(a)
    1 ↔ 1
    2R(16708771-16723569)
    worm
    (Caenorhabditis elegans)
    Secernentea insc-16
    Protein INSC-1
    14(a)
    1 ↔ 1
    II(7359961-7363245)


    ENSEMBL Gene Tree for INSC (if available)
    TreeFam Gene Tree for INSC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2919 SNPs in INSC are shown (see all 2919)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1822417981,2
    --15132027(+) GGAACA/TTTTTA 1 -- us2k10--------
    rs343822421,2
    C,F--15132050(+) CTTCAG/ACTCAG 1 -- us2k14Minor allele frequency- A:0.08NA 126
    rs1874397211,2
    --15132220(+) GACAAC/TAGAAA 1 -- us2k10--------
    rs1889586081,2
    --15132234(+) TTGGGA/GAATTC 1 -- us2k10--------
    rs1816075061,2
    --15132417(+) CTGGCA/GGACTG 1 -- us2k10--------
    rs1416421261,2
    --15132443(+) TCCTGC/TATGTC 1 -- us2k10--------
    rs1855389111,2
    --15132531(+) GGCCAA/GTAAGC 1 -- us2k10--------
    rs110234381,2
    --15132588(+) CTGGCC/GCCAAT 1 -- us2k10--------
    rs107342311,2
    C,F,H--15132593(+) CCCAAC/TCCCTG 1 -- us2k118Minor allele frequency- T:0.02NS NA WA CSA EA 1165
    rs1481425931,2
    --15132600(+) CCTGTC/TTCCTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for INSC (15133970 - 15268754 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for INSC:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv516403CNV Loss19592680
    nsv897007CNV Gain21882294
    nsv832072CNV Gain17160897
    nsv897010CNV Gain21882294
    nsv897009CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing INSC
    DNA2.0 Custom Variant and Variant Library Synthesis for INSC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610668    OMIM disorders: --

    3 diseases for INSC:    About MalaCards
    optic disk drusen    protein c deficiency    neuronitis

    1 disease from the University of Copenhagen DISEASES database for INSC:
    Optic disk drusen

    INSC for disorders           About GeneDecksing

    Genetic Association Database (GAD): INSC
    Human Genome Epidemiology (HuGE) Navigator: INSC (6 documents)

    Export disorders for INSC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for INSC gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with INSC)
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    1. Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3. (PubMed id 16458856)1, 2, 3 Izaki T.... Sumimoto H. (2006)
    2. A genome-wide search for loci interacting with known p rostate cancer risk-associated genetic variants. (PubMed id 22219177)1, 4 Tao S....Sun J. (2012)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Identification and characterization of human Inscuteable gene in silico. (PubMed id 12469229)1, 2 Katoh M. and Katoh M. (2003)
    5. Genome wide association study of age at menarche in th e Japanese population. (PubMed id 23667675)1 Tanikawa C....Matsuda K. (2013)
    6. On the inscrutable role of Inscuteable: structural bas is and functional implications for the competitive binding of NuMA and Inscuteab le to LGN. (PubMed id 22977735)1 Mapelli M. and Gonzalez C. (2012)
    7. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)
    8. Proteomics strategy to identify substrates of LNX, a P DZ domain-containing E3 ubiquitin ligase. (PubMed id 22889411)1 Guo Z....Gao Y. (2012)
    9. Structural basis for interaction between the conserve d cell polarity proteins Inscuteable and Leu-Gly-Asn repeat-enriched protein (L GN). (PubMed id 22074847)1 Yuzawa S....Sumimoto H. (2011)
    10. Distribution of activator of G-protein signaling 3 wi thin the aggresomal pathway: role of specific residues in the tetratricopeptide repeat domain and differential regulation by the AGS3 binding partners Gi(alph a) and mammalian inscuteable. (PubMed id 20065032)1 Vural A....Lanier S.M. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 387755 HGNC: 33116 AceView: LOC387755 Ensembl:ENSG00000188487 euGenes: HUgn387755
    ECgene: INSC H-InvDB: INSC

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for INSC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for INSC gene:
    Search GeneIP for patents involving INSC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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