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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

INS-IGF2 Gene

protein-coding   GIFtS: 36
GCID: GC11M002120

INS-IGF2 Readthrough

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 4

Aliases
INS-IGF2 Readthrough1 2
INS-IGF2 Readthrough Transcript Protein2 3
INSIGF2
insulin2
Insulin- Insulin-Like Growth Factor 2 Read-Through Product2

External Ids:    HGNC: 335271   Entrez Gene: 7239612   Ensembl: ENSG000001299657   UniProtKB: F8WCM53   
ORGUL members:    fRNAdb10:FR407519 FR279901      
H-InvDB12:HIT000089232 HIT000215693    
NCBI13:BC017277 S51971    
NONCODE14:n335752 n406123      
RNAdb15:HIV2512    

Export aliases for INS-IGF2 gene to outside databases

Previous GC identifers: GC11U900700 GC11M002124 GC11M002116 GC11M002119 GC11M001940


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for INS-IGF2 Gene:
This locus includes two alternatively spliced read-through transcript variants which align to the INS gene in the
5' region and to the IGF2 gene in the 3' region. One transcript is predicted to encode a protein which shares the
N-terminus with the INS protein but has a distinct and longer C-terminus, whereas the other transcript is a
candidate for nonsense-mediated decay (NMD). The transcripts are imprinted and are paternally expressed in the
limb and eye. (provided by RefSeq, Jul 2008)

GeneCards Summary for INS-IGF2 Gene: 
INS-IGF2 (INS-IGF2 readthrough) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with INS-IGF2 include beckwith-wiedemann syndrome, and type 1 diabetes, and among its related super-pathways are Type II diabetes mellitus. An important paralog of this gene is INS.



fRNAdb sequence ontology for INS-IGF2:
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

View fRNAdb secondary structures for INS-IGF2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for INS-IGF2
         Other transcription factors

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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INS-IGF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

INS-IGF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INS-IGF2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M002120:  view genomic region     (about GC identifiers)

Start:
2,150,342 bp from pter      End:
2,182,439 bp from pter
Size:
32,098 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for INS-IGF2

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: INSR2_HUMAN, F8WCM5 (See protein sequence)
Recommended Name: Insulin, isoform 2  
Size: 200 amino acids; 21537 Da
Secondary accessions: Q1WM24
Alternative splicing: 2 isoforms:  F8WCM5-1   P01308-1   (Based on a readthrough transcript which may produce an INS-IGF2 fusion protein)

Explore the universe of human proteins at neXtProt for INS-IGF2: NX_F8WCM5

Explore proteomics data for INS-IGF2 at MOPED 

INS-IGF2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

INS-IGF2 Protein Expression

REFSEQ proteins: NP_001035835.1  
ENSEMBL proteins: 
 ENSP00000348986   ENSP00000380440  

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--

INS-IGF2 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
2 InterPro protein domains:
 IPR016179 Insulin-like
 IPR004825 Insulin

Graphical View of Domain Structure for InterPro Entry F8WCM5

ProtoNet protein and cluster: F8WCM5


INS-IGF2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005179hormone activity IEA--
     
INS-IGF2 for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for INS-IGF2 About                                                                                                See pathways by source

SuperPathContained pathways About
1Type II diabetes mellitus
Type II diabetes mellitus0.35
2AMPK signaling
AMPK signaling


2 BioSystems Pathways for INS-IGF2
    AMPK signaling
Type II diabetes mellitus


Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for INS-IGF2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/164 Interacting proteins for INS-IGF2 (ENSP000003489864) via UniProtKB, MINT, STRING, and/or I2D (see all 164)
InteractantInteraction Details
GeneCardExternal ID(s)
IDEENSP000002659864STRING: ENSP00000265986
AKT1ENSP000002702024STRING: ENSP00000270202
AKT2ENSP000003758924STRING: ENSP00000375892
ALAS1ENSP000003092594STRING: ENSP00000309259
ATP6V0A1ENSP000002646494STRING: ENSP00000264649
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for INS-IGF2 (INSR2)

Search CenterWatch for drugs/clinical trials and news about INS-IGF2 / INSR2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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About This Section
2 fRNAdb Secondary structures:


REFSEQ mRNAs for INS-IGF2 gene: 
NM_001042376.2  

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000356578 ENST00000481781 ENST00000397270(uc001lvm.3) ENST00000476874

miRNA
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GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for INS-IGF2 (see all 6)    About this scheme

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d
SP1:                                                      
SP2:                    -                                 
SP3:                    -           -                     
SP4:                    -           -     -               
SP5:                                                      


ECgene alternative splicing isoforms for INS-IGF2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

INS-IGF2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
INS-IGF2 Expression
About this image


See INS-IGF2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for INS-IGF2

UniProtKB/Swiss-Prot: INSR2_HUMAN, F8WCM5
Tissue specificity: Expressed in pancreas, eye and, to a lower extent, in limb

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INS-IGF2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for INS-IGF2 gene from 3/7 species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves INS6
Insulin Insulin B chain Insulin A chain
44(a)
1 → many
5(13125200-13129792)
lizard
(Anolis carolinensis)
Reptilia --
--
42(a)
1 → many
1(69965277-69969077)
zebrafish
(Danio rerio)
Actinopterygii ins6
insb6
preproinsulin b
30(a)
20(a)
many ↔ many
many ↔ many
5(39454959-39457905)
14(29583203-29588274)
        Species with no ortholog for INS-IGF2

ENSEMBL Gene Tree for INS-IGF2 (if available)
TreeFam Gene Tree for INS-IGF2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for INS-IGF2 gene
INS2  
1 SIMAP similar gene for INS-IGF2 using alignment to 1 protein entry:     INSR2_HUMAN:
INS

INS-IGF2 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/131 SNPs in INS-IGF2 are shown (see all 131)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs178831311,2
C,F--2173086(+) GGGCTG/ATGGCC 2 -- int13Minor allele frequency- A:0.02NS WA 204
rs1511449231,2
--2173121(+) CCTAAA/GCCACA 2 -- int10--------
rs1402627291,2
--2173325(+) CACCCA/GGCTCC 2 -- int10--------
rs1485445311,2
C--2173411(+) TTCAG-/AAAAAAGC 2 -- cds1 int10--------
rs79243161,2
C,F,A,H--2173447(+) GACCGT/GAGCTA 2 -- int137Minor allele frequency- G:0.44NS EA NA WA CSA 4441
rs792518841,2
F--2173537(+) TGGCCC/ACAGAG 2 -- int11Minor allele frequency- A:0.02WA 118
rs1926300131,2
--2173627(+) CAGCCC/TGAGGG 2 -- int10--------
rs766414801,2
C--2173907(+) CCACAG/TGTCCA 2 -- int10--------
rs797619711,2
C--2173908(+) CACAGC/GTCCAC 2 -- int10--------
rs1854621541,2
--2174090(+) CAAGAC/GTCTCA 2 -- int10--------

HapMap Linkage Disequilibrium report for INS-IGF2 (2150342 - 2182439 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/17 variations for INS-IGF2 (see all 17):    About this table     
Variant IDTypeSubtypePubMed ID
esv2673506CNV Deletion23128226
dgv996n71CNV Loss21882294
nsv896776CNV Loss21882294
nsv896785CNV Loss21882294
dgv994n71CNV Loss21882294
nsv896796CNV Loss21882294
dgv998n71CNV Loss21882294
dgv995n71CNV Loss21882294
nsv896798CNV Loss21882294
nsv896797CNV Loss21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM information: 147470 194071 604499 607967 609270 609470    
3 diseases for INS-IGF2:    About MalaCards
beckwith-wiedemann syndrome    type 1 diabetes    diabetes mellitus


INS-IGF2 for disorders           About GeneDecksing

Genetic Association Database (GAD): INS-IGF2
Human Genome Epidemiology (HuGE) Navigator: INS-IGF2 (4 documents)

Export disorders for INS-IGF2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for INS-IGF2 gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with INS-IGF2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Imprinting of IGF2 P0 transcript and novel alternatively spliced INS- IGF2 isoforms show differences between mouse and human. (PubMed id 16531418)1, 2, 3 Monk D.... Moore G.E. (2006)
  2. Genome-wide association analysis of autoantibody posit ivity in type 1 diabetes cases. (PubMed id 21829393)1, 4 Plagnol V....Todd J.A. (2011)
  3. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
  4. A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene. (PubMed id 17632545)1, 4 Hakonarson H....Polychronakos C. (2007)
  5. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. (PubMed id 17554260)1, 4 Todd J.A.... Clayton D.G. (2007)
  6. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)1 Prakash T....Taylor T.D. (2010)
  7. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
  8. Association between small for gestational age and paternally inherited 5' insulin haplotypes. (PubMed id 17700581)1 Adkins R.M....Somes G. (2008)
  9. Association between paternally inherited haplotypes upstream of the insulin gene and umbilical cord IGF-II levels. (PubMed id 17667841)1 Adkins R.M....Morrison J.C. (2007)
  10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 723961 HGNC: 33527 Ensembl:ENSG00000129965 euGenes: HUgn723961 ECgene: INS-IGF2
H-InvDB: INS-IGF2

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for INS-IGF2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for INS-IGF2 gene:
Search GeneIP for patents involving INS-IGF2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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About This Section

 
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 Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
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 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat INS-IGF2
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 inGenious Targeting Laboratory - Custom generated mouse model solutions for INS-IGF2
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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