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Aliasesfor INS-IGF2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
10 fRNAdb ,
12 H-InvDB ,
13 NCBI ,
14 NONCODE ,
and/or 15 RNAdb )About This Section Subcategory (RNA class): lncRNAQuality score for the ORGUL clustered with this gene is 4 Aliases INS-IGF2 Readthrough 1 2 INS-IGF2 Readthrough Transcript Protein2 3 INSIGF2 insulin2 Insulin- Insulin-Like Growth Factor 2 Read-Through Product2
External Ids: HGNC: 33527 1 Entrez Gene: 723961 2 Ensembl: ENSG00000129965 7 UniProtKB: F8WCM5 3 Export aliases for INS-IGF2 gene to outside databases Previous GC identifers: GC11U900700 GC11M002124 GC11M002116 GC11M002119 GC11M001940
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Summariesfor INS-IGF2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for INS-IGF2 Gene: This locus includes two alternatively spliced read-through transcript variants which align to the INS gene in the5' region and to the IGF2 gene in the 3' region. One transcript is predicted to encode a protein which shares theN-terminus with the INS protein but has a distinct and longer C-terminus, whereas the other transcript is acandidate for nonsense-mediated decay (NMD). The transcripts are imprinted and are paternally expressed in thelimb and eye. (provided by RefSeq, Jul 2008) GeneCards Summary for INS-IGF2 Gene: INS-IGF2 (INS-IGF2 readthrough) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with INS-IGF2 include beckwith-wiedemann syndrome type 1 diabetes related super-pathways are Type II diabetes mellitus . An important paralog of this gene is INS . fRNAdb sequence ontology for INS-IGF2: ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.View fRNAdb secondary structures for INS-IGF2
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Genomic Viewsfor INS-IGF2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 73) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for INS-IGF2 Other transcription factors Search SABiosciences Chromatin IP Primers for INS-IGF2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INS-IGF2
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 11p15.5 Ensembl cytogenetic band: 11p15.5 HGNC cytogenetic band: 11p15.5 INS-IGF2 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 11 GeneLoc Exon Structure
GeneLoc location for GC11M002120: view genomic region
(about GC identifiers )
Start: 2,150,342 bp from pter End:
2,182,439 bp from pter
Size: 32,098 bases Orientation:
minus strand
ORGUL member locations:Legend (see complete legend)
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Proteinsfor INS-IGF2 gene
(According to
UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE 1 MOPED ,
2 PaxDb , and 3 MAXQB
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Cloud-Clone Corp. ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Cloud-Clone Corp. ,
Ontologies according to Gene
Ontology Consortium 01 Oct 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
LSBio ,
Abcam , and/or
Cloud-Clone Corp. )
About This Section UniProtKB/Swiss-Prot: INSR2_HUMAN, F8WCM5 See
protein sequence )Recommended Name: Size : 200 amino acids; 21537 DaSecondary accessions : Q1WM24Alternative splicing : 2 isoforms : F8WCM5-1 P01308-1 (Based on a readthrough transcript which may produce an INS-IGF2 fusion protein)Explore the universe of human proteins at neXtProt for INS-IGF2: NX_F8WCM5 Explore proteomics data for INS-IGF2 at MOPED INS-IGF2 Protein expression data from MOPED1 2 3 : About this image
REFSEQ proteins: NP_001035835.1 ENSEMBL proteins: ENSP00000348986 ENSP00000380440 Human Recombinant Protein Products for INS-IGF2: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005576 extracellular region
IEA --
About GeneDecksing INS-IGF2 Antibody Products: Assay Products for INS-IGF2:
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Protein
Domains /for INS-IGF2 gene (According to HGNC , IUPHAR , InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section 2 InterPro protein domains :
Graphical View of Domain Structure for InterPro Entry F8WCM5 ProtoNet protein and cluster: F8WCM5
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Functionfor INS-IGF2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
genOway ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
Vector BioLabs ,
and Sirion Biotech ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene .)
About This Section Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005179 hormone activity
IEA --
About GeneDecksing Animal Models: Cell Line GenScript Custom overexpressing Cell Line Services for INS-IGF2 Search LifeMap BioReagents cell lines for INS-IGF2 In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INS-IGF2
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Pathways & Interactionsfor INS-IGF2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Sino Biological ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene) .
About This Section SuperPaths for INS-IGF2 About See pathways by source SuperPath Contained pathways About 1 Type II diabetes mellitus 2 AMPK signaling
2 Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for INS-IGF2 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/164 Interacting proteins for INS-IGF2 (ENSP00000348986 4 via UniProtKB, MINT, STRING , and/or I2D (see all 164 )About this table
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Drugs & Compoundsfor INS-IGF2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek ,
Ligands according to IUPHAR ,
and Drugs according to DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for INS-IGF2 (INSR2) INS-IGF2 / INSR2
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Transcriptsfor INS-IGF2 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , KenesGroup ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Sirion Biotech ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section 2 fRNAdb Secondary structures: REFSEQ mRNAs for INS-IGF2 gene: NM_001042376.2 4 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000356578 ENST00000481781 ENST00000397270 (uc001lvm.3 ) ENST00000476874 Primer human mouse SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat
GeneLoc Exon Structure 5/6 Alternative Splicing Database (ASD) splice patterns (SP) for INS-IGF2 (see all 6 ) About this scheme ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d SP1 : SP2 : - SP3 : - - SP4 : - - - SP5 :
ECgene alternative splicing isoforms for INS-IGF2
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Expression for INS-IGF2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section INS-IGF2 expression in normal human tissues
(normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS 2/3 CGAP TAG: -- About this image
See INS-IGF2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for INS-IGF2 UniProtKB/Swiss-Prot: INSR2_HUMAN, F8WCM5 Tissue specificity : Expressed in pancreas, eye and, to a lower extent, in limbSABiosciences Custom PCR Arrays for INS-IGF2 Primer human mouse SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INS-IGF2
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Orthologsfor INS-IGF2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for INS-IGF2 gene from 3/7 species (see all 7 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
chicken Aves INS6
Insulin Insulin B chain Insulin A chain
44(a)
1 → many
5(13125200-13129792)
lizard Reptilia --
--
42(a)
1 → many
1(69965277-69969077)
zebrafish Actinopterygii ins6 6
preproinsulin b
30(a) 20(a)
many ↔ manymany ↔ many
5(39454959-39457905) 14(29583203-29588274)
Species with no ortholog for INS-IGF2 ENSEMBL Gene Tree for INS-IGF2 (if available)TreeFam Gene Tree for INS-IGF2 (if available)
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Paralogsfor INS-IGF2 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for INS-IGF2 gene INS 2 1 SIMAP similar gene for INS-IGF2 using alignment to 1 protein entry: INSR2_HUMAN :INS About GeneDecksing
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Genomic Variantsfor INS-IGF2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
4 UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 11 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for INS-IGF2 (2150342 - 2182439 bp)
Structural Variations Database of Genomic Variants (DGV) 10/17 variations for INS-IGF2 (see all 17 ): About this table SABiosciences Cancer Mutation PCR Assays
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Disorders
/ Diseasesfor INS-IGF2 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Conferences by KenesGroup ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section OMIM information: 147470 194071 604499 607967 609270 609470 3 : About MalaCards beckwith-wiedemann syndrome type 1 diabetes diabetes mellitus About GeneDecksing Genetic Association Database (GAD): INS-IGF2 Human Genome Epidemiology (HuGE) Navigator: INS-IGF2 (4 documents) Export disorders for INS-IGF2 gene to outside databases
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Publicationsfor INS-IGF2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for INS-IGF2 gene, integrated from 9 sources (see all 24 ):(articles sorted by number of sources associating them with INS-IGF2) Utopia : connect your pdf to the dynamic
Imprinting of IGF2 P0 transcript and novel alternatively spliced INS- IGF2 isoforms show differences between mouse and human. (PubMed id 16531418) 1 , 2 , 3(2006) Genome-wide association analysis of autoantibody posit ivity in type 1 diabetes cases. (PubMed id 21829393) 1 , 4(2011) Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086) 1 , 4(2010) A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene. (PubMed id 17632545) 1 , 4(2007) Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. (PubMed id 17554260) 1 , 4(2007) Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262) 1 (2010) Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121) 1 (2009) Association between small for gestational age and paternally inherited 5' insulin haplotypes. (PubMed id 17700581) 1 (2008) Association between paternally inherited haplotypes upstream of the insulin gene and umbilical cord IGF-II levels. (PubMed id 17667841) 1 (2007) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 (2006)
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External Searches for INS-IGF2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing INS-IGF2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing INS-IGF2 gene
(According to HUGE )
About This Section --
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Specialized Databases showing INS-IGF2 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for INS-IGF2 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for INS-IGF2 gene: INS-IGF2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor INS-IGF2 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Cloud-Clone Corp. , Thermo Fisher Scientific , LSBio , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Sirion Biotech , Cell lines from GenScript , and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory ,
genOway )About This Section
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat INS-IGF2 Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing INS-IGF2 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INS-IGF2 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INS-IGF2
Search ThermoFisher Antibodies for INS-IGF2
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse rat INS-IGF2
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