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INS-IGF2 Gene(Protein Coding)

INS-IGF2 Readthrough

GCID:
GC11M002133
GIFtS:
32
Genes Participants
UDN Logo

Aliases for INS-IGF2 Gene

Aliases for INS-IGF2 Gene

  • INS-IGF2 Readthrough 2 3 5
  • INS-IGF2 Readthrough Transcript Protein 3 4
  • Insulin- Insulin-Like Growth Factor 2 Read-Through Product 3
  • INSIGF 3

External Ids for INS-IGF2 Gene

Previous GeneCards Identifiers for INS-IGF2 Gene

  • GC11U900700
  • GC11M002124
  • GC11M002116
  • GC11M002119
  • GC11M002120
  • GC11M001940
  • GC11M002171
  • GC11M002131
  • GC11M002132

Summaries for INS-IGF2 Gene

Entrez Gene Summary for INS-IGF2 Gene

  • This locus includes two alternatively spliced read-through transcript variants which align to the INS gene in the 5' region and to the IGF2 gene in the 3' region. One transcript is predicted to encode a protein which shares the N-terminus with the INS protein but has a distinct and longer C-terminus, whereas the other transcript is a candidate for nonsense-mediated decay (NMD). The transcripts are imprinted and are paternally expressed in the limb and eye. [provided by RefSeq, Jul 2008]

GeneCards Summary for INS-IGF2 Gene

INS-IGF2 (INS-IGF2 Readthrough) is a Protein Coding gene. Among its related pathways are Type II diabetes mellitus and AMPK signaling pathway. GO annotations related to this gene include hormone activity. An important paralog of this gene is INS.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INS-IGF2 Gene

Genomics for INS-IGF2 Gene

Products:

  1. Regulatory Element

Regulatory Elements for INS-IGF2 Gene

Enhancers for INS-IGF2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around INS-IGF2 on UCSC Golden Path with GeneCards custom track

Genomic Location for INS-IGF2 Gene

Chromosome:
11
Start:
2,129,112 bp from pter
End:
2,161,209 bp from pter
Size:
32,098 bases
Orientation:
Minus strand

Genomic View for INS-IGF2 Gene

Genes around INS-IGF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INS-IGF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INS-IGF2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for INS-IGF2 Gene

Proteins for INS-IGF2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for INS-IGF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    F8WCM5-INSR2_HUMAN
    Recommended name:
    Insulin, isoform 2
    Protein Accession:
    F8WCM5
    Secondary Accessions:
    • Q1WM24

    Protein attributes for INS-IGF2 Gene

    Size:
    200 amino acids
    Molecular mass:
    21537 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for INS-IGF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for INS-IGF2 Gene

Proteomics data for INS-IGF2 Gene at MOPED

Post-translational modifications for INS-IGF2 Gene

No Post-translational modifications

Other Protein References for INS-IGF2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for INS-IGF2 Gene

Domains & Families for INS-IGF2 Gene

Protein Domains for INS-IGF2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with INS-IGF2: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for INS-IGF2 Gene

Function for INS-IGF2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Phenotypes for INS-IGF2 Gene

GenomeRNAi human phenotypes for INS-IGF2:
genes like me logo Genes that share phenotypes with INS-IGF2: view

Animal Model Products

CRISPR Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for INS-IGF2 Gene

Localization for INS-IGF2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for INS-IGF2 Gene COMPARTMENTS Subcellular localization image for INS-IGF2 gene
Compartment Confidence
extracellular 4

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for INS-IGF2 Gene

Pathways & Interactions for INS-IGF2 Gene

genes like me logo Genes that share pathways with INS-IGF2: view

Pathways by source for INS-IGF2 Gene

2 BioSystems pathways for INS-IGF2 Gene

Interacting Proteins for INS-IGF2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000348986%0d%0a9606.ENSP00000303830%0d%0a9606.ENSP00000265986%0d%0a
Selected Interacting proteins: ENSP00000348986 for INS-IGF2 Gene via STRING

Gene Ontology (GO) - Biological Process for INS-IGF2 Gene

None

No data available for SIGNOR curated interactions for INS-IGF2 Gene

Drugs & Compounds for INS-IGF2 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for INS-IGF2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for INS-IGF2 Gene

(1) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for INS-IGF2 Gene

No ASD Table

Relevant External Links for INS-IGF2 Gene

GeneLoc Exon Structure for
INS-IGF2
ECgene alternative splicing isoforms for
INS-IGF2

Expression for INS-IGF2 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for INS-IGF2 Gene

mRNA expression in normal human tissues for INS-IGF2 Gene
mRNA expression by BioGPS for INS-IGF2 GenemRNA expression by GTEx for INS-IGF2 Gene

mRNA differential expression in normal tissues according to GTEx for INS-IGF2 Gene

This gene is overexpressed in Liver (x45.9).

mRNA Expression by UniProt/SwissProt for INS-IGF2 Gene

F8WCM5-INSR2_HUMAN
Tissue specificity: Expressed in pancreas, eye and, to a lower extent, in limb.
genes like me logo Genes that share expression patterns with INS-IGF2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for INS-IGF2 Gene

Orthologs for INS-IGF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for INS-IGF2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
 Mammalia INS 36
  • 69 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves INS 36
  • 46 (a)
 OneToMany
lizard
(Anolis carolinensis)
 Reptilia -- 36
  • 44 (a)
 OneToMany
zebrafish
(Danio rerio)
 Actinopterygii ins 36
  • 33 (a)
 ManyToMany
insb 36
  • 23 (a)
 ManyToMany
Species with no ortholog for INS-IGF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for INS-IGF2 Gene

ENSEMBL:
Gene Tree for INS-IGF2 (if available)
TreeFam:
Gene Tree for INS-IGF2 (if available)

Paralogs for INS-IGF2 Gene

Paralogs for INS-IGF2 Gene

(1) SIMAP similar genes for INS-IGF2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with INS-IGF2: view

Variants for INS-IGF2 Gene

Sequence variations from dbSNP and Humsavar for INS-IGF2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs2000993 -- 2,157,386(-) CCACC(A/G)GGCTG intron-variant
rs7118040 -- 2,156,360(+) CTGCA(A/G)TGCCC intron-variant
rs11564722 -- 2,157,100(-) GGCAC(A/G)TGCTC intron-variant
rs11564723 -- 2,157,037(-) ATTGC(A/G)TCTGC intron-variant
rs11564724 -- 2,156,199(-) GCGAG(C/T)CCCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for INS-IGF2 Gene

Variant ID Type Subtype PubMed ID
nsv467645 CNV Gain 19166990
dgv992n71 CNV Loss 21882294
dgv993n71 CNV Loss 21882294
nsv896776 CNV Loss 21882294
dgv994n71 CNV Loss 21882294
dgv995n71 CNV Loss 21882294
nsv825707 CNV Gain 20364138
dgv996n71 CNV Loss 21882294
nsv896785 CNV Loss 21882294
esv2673506 CNV Deletion 23128226
dgv997n71 CNV Loss 21882294
dgv998n71 CNV Loss 21882294
nsv896793 CNV Gain 21882294
nsv896794 CNV Gain+Loss 21882294
nsv896796 CNV Loss 21882294
nsv896797 CNV Loss 21882294
nsv896798 CNV Loss 21882294

Variation tolerance for INS-IGF2 Gene

Residual Variation Intolerance Score: 72.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.00; 68.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for INS-IGF2 Gene

Human Gene Mutation Database (HGMD)
INS-IGF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INS-IGF2 Gene

Disorders for INS-IGF2 Gene

Relevant External Links for INS-IGF2

Genetic Association Database (GAD)
INS-IGF2
Human Genome Epidemiology (HuGE) Navigator
INS-IGF2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
INS-IGF2

No disorders were found for INS-IGF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for INS-IGF2 Gene

Publications for INS-IGF2 Gene

  1. Imprinting of IGF2 P0 transcript and novel alternatively spliced INS- IGF2 isoforms show differences between mouse and human. (PMID: 16531418) Monk D. … Moore G.E. (Hum. Mol. Genet. 2006) 2 3 4 67
  2. Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes. (PMID: 25102180) Ng M.C. … Bowden D.W. (PLoS Genet. 2014) 3
  3. Autoimmunity against INS-IGF2 protein expressed in human pancreatic islets. (PMID: 23935095) Kanatsuna N. … Lernmark A.8. (J. Biol. Chem. 2013) 3
  4. Periconception maternal smoking and low education are associated with methylation of INSIGF in children at the age of 17 months. (PMID: 25102259) Obermann-Borst S.A. … Steegers-Theunissen R.P. (J Dev Orig Health Dis 2012) 3
  5. Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. (PMID: 21829393) Plagnol V. … Todd J.A. (PLoS Genet. 2011) 3

Products for INS-IGF2 Gene

Sources for INS-IGF2 Gene

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