Aliases for INS-IGF2 Gene
Aliases for INS-IGF2 Gene
External Ids for INS-IGF2 Gene
- HGNC: 33527
- Entrez Gene: 723961
- Ensembl: ENSG00000129965
- UniProtKB: F8WCM5
Previous GeneCards Identifiers for INS-IGF2 Gene
- GC11U900700
- GC11M002124
- GC11M002116
- GC11M002119
- GC11M002120
- GC11M001940
- GC11M002171
- GC11M002131
- GC11M002132
- GC11M002133
- GC11M002135
- GC11M002142
Summaries for INS-IGF2 Gene
-
This locus includes two alternatively spliced read-through transcript variants which align to the INS gene in the 5' region and to the IGF2 gene in the 3' region. One transcript is predicted to encode a protein which shares the N-terminus with the INS protein but has a distinct and longer C-terminus, whereas the other transcript is a candidate for nonsense-mediated decay (NMD). The transcripts are imprinted and are paternally expressed in the limb and eye. [provided by RefSeq, Jul 2008]
GeneCards Summary for INS-IGF2 Gene
INS-IGF2 (INS-IGF2 Readthrough) is a Protein Coding gene. Diseases associated with INS-IGF2 include Diabetes Mellitus, Insulin-Dependent, 2. Among its related pathways are AMP-activated Protein Kinase (AMPK) Signaling and Type II diabetes mellitus. GO annotations related to this gene include hormone activity. An important paralog of this gene is INS.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INS-IGF2 Gene
Genomics for INS-IGF2 Gene
Regulatory Elements for INS-IGF2 Gene
Enhancers for INS-IGF2 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH11G002186 | 1.3 | Ensembl ENCODE dbSUPER | 11.6 | -25.6 | -25616 | 0.8 | CTCF ZNF473 ZSCAN4 MAX GLI4 CDC5L THRB ZIC2 RAD21 ZNF776 | INS INS-IGF2 IGF2 ENSG00000199550 CD81 TH MIR4686 GC11M002206 |
| GH11G002026 | 0.5 | ENCODE | 11.4 | +131.6 | 131599 | 6.4 | SCRT2 ZNF16 PRDM4 HNRNPL | ENSG00000240801 MIR483 TH IGF2-AS IGF2 INS INS-IGF2 KRTAP5-5 GC11P002011 GC11M002042 |
| GH11G002156 | 1 | ENCODE dbSUPER | 0.7 | +4.6 | 4584 | 0.2 | GATAD2A CTCF ZNF654 RB1 MAX REST ZIC2 RAD21 YY1 RFX5 | INS-IGF2 IGF2 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around INS-IGF2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for INS-IGF2 Gene
- Chromosome:
- 11
- Start:
- 2,129,112 bp from pter
- End:
- 2,161,209 bp from pter
- Size:
- 32,098 bases
- Orientation:
- Minus strand
Genomic View for INS-IGF2 Gene
Genes around INS-IGF2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p15.5 by Ensembl
- 11p15.5 by Entrez Gene
- 11p15.5 by HGNC
INS-IGF2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for INS-IGF2 Gene
Proteins for INS-IGF2 Gene
-
Protein details for INS-IGF2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- F8WCM5-INSR2_HUMAN
- Recommended name:
- Insulin, isoform 2
- Protein Accession:
- F8WCM5
- Q1WM24
Protein attributes for INS-IGF2 Gene
- Size:
- 200 amino acids
- Molecular mass:
- 21537 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for INS-IGF2 Gene
No Post-translational modifications
Other Protein References for INS-IGF2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for INS-IGF2
- Search GeneTex for Antibodies for INS-IGF2
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for INS-IGF2
- Origene Custom Protein Services for INS-IGF2
- Search GeneTex for Proteins for INS-IGF2
Assay Products
No data available for DME Specific Peptides for INS-IGF2 Gene
Domains & Families for INS-IGF2 Gene
Protein Domains for INS-IGF2 Gene
- InterPro:
- ProtoNet:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for INS-IGF2 Gene
Function for INS-IGF2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005179 | hormone activity | IEA | -- |
Phenotypes for INS-IGF2 Gene
- GenomeRNAi human phenotypes for INS-IGF2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for INS-IGF2
-
-
ViGene Biosciences ready-to-package AAV shRNAs for INS-IGF2 gene
- Search ViGene Biosciences for INS-IGF2
CRISPR Products
- Browse CRISPR knockouts for INS-IGF2
- GenScript: Design CRISPR guide RNA sequences for INS-IGF2
miRNA Products
- Search ViGene Biosciences for INS-IGF2
Inhibitory RNA Products
-
ViGene Biosciences ready-to-package AAV shRNAs for INS-IGF2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for INS-IGF2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for INS-IGF2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for INS-IGF2
-
ViGene Biosciences adenoviral particle packaged cDNA for INS-IGF2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for INS-IGF2 gene
- Search ViGene Biosciences for INS-IGF2
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for INS-IGF2 Gene
Localization for INS-IGF2 Gene
| Compartment | Confidence |
|---|---|
| extracellular | 4 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for INS-IGF2 Gene
Pathways & Interactions for INS-IGF2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | AMP-activated Protein Kinase (AMPK) Signaling | ||
| 2 | Type II diabetes mellitus | ||
Pathways by source for INS-IGF2 Gene
2 BioSystems pathways for INS-IGF2 Gene
Interacting Proteins for INS-IGF2 Gene
No data available for SIGNOR curated interactions for INS-IGF2 Gene
Transcripts for INS-IGF2 Gene
mRNA/cDNA for INS-IGF2 Gene
- (1) REFSEQ mRNAs :
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for INS-IGF2
- GenScript: Design CRISPR guide RNA sequences for INS-IGF2
miRNA Products
- Search ViGene Biosciences for INS-IGF2
Inhibitory RNA Products
-
ViGene Biosciences ready-to-package AAV shRNAs for INS-IGF2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for INS-IGF2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for INS-IGF2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for INS-IGF2 Gene
mRNA differential expression in normal tissues according to GTEx for INS-IGF2 Gene
This gene is overexpressed in Liver (x45.9).
mRNA Expression by UniProt/SwissProt for INS-IGF2 Gene:
F8WCM5-INSR2_HUMAN
Tissue specificity:
Expressed in pancreas, eye and, to a lower extent, in limb.
Evidence on tissue expression from TISSUES for INS-IGF2 Gene
- Pancreas(2.9)
Primer Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for INS-IGF2 Gene
Orthologs for INS-IGF2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| dog (Canis familiaris) |
Mammalia | INS 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | INS 35 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | ins 35 |
|
ManyToMany | |
| insb 35 |
|
ManyToMany |
- Species where no ortholog for INS-IGF2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for INS-IGF2 Gene
(1) SIMAP similar genes for INS-IGF2 Gene using alignment to 1 proteins:
Variants for INS-IGF2 Gene
| SNP ID | Clin | Chr 11 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs121908260 | Pathogenic | 2,160,835(-) | GGAAC(A/G)AGGCT | nc-transcript-variant, reference, missense | |
| rs121908261 | Pathogenic | 2,160,809(-) | AGACC(C/T)GCCGG | nc-transcript-variant, reference, missense | |
| rs121908278 | Pathogenic | 2,160,956(-) | GGATG(C/G/T)GCCTC | nc-transcript-variant, reference, missense | |
| rs121918101 | Pathogenic | 2,160,872(-) | GCTCA(C/G)ACCTG | nc-transcript-variant, reference, missense | |
| rs121918102 | Pathogenic | 2,159,911(-) | GCATT(G/T)TGGAA | intron-variant, reference, missense |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1566n54 | CNV | loss | 21841781 |
| dgv1567n54 | CNV | loss | 21841781 |
| dgv551e59 | CNV | duplication | 20981092 |
| esv2673506 | CNV | deletion | 23128226 |
| nsv1070426 | CNV | deletion | 25765185 |
| nsv1118203 | CNV | deletion | 24896259 |
| nsv467645 | CNV | gain | 19166990 |
| nsv553047 | CNV | gain | 21841781 |
| nsv553068 | CNV | loss | 21841781 |
| nsv553069 | CNV | loss | 21841781 |
| nsv553070 | CNV | loss | 21841781 |
| nsv553071 | CNV | gain | 21841781 |
| nsv553076 | CNV | loss | 21841781 |
| nsv553077 | CNV | loss | 21841781 |
| nsv553078 | CNV | loss | 21841781 |
| nsv825707 | CNV | gain | 20364138 |
| nsv951284 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
72.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.00;
68.35% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for INS-IGF2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INS-IGF2 Gene
Disorders for INS-IGF2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| diabetes mellitus, insulin-dependent, 2 |
|
|
Search INS-IGF2 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for INS-IGF2
No data available for UniProtKB/Swiss-Prot and Genatlas for INS-IGF2 Gene
Publications for INS-IGF2 Gene
- Imprinting of IGF2 P0 transcript and novel alternatively spliced INS- IGF2 isoforms show differences between mouse and human. (PMID: 16531418) Monk D. … Moore G.E. (Hum. Mol. Genet. 2006) 2 3 4 64
- Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. (PMID: 21829393) Plagnol V. … Todd J.A. (PLoS Genet. 2011) 3 46 64
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
- Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. (PMID: 17554260) Todd J.A. … Clayton D.G. (Nat. Genet. 2007) 3 46 64
- A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene. (PMID: 17632545) Hakonarson H. … Polychronakos C. (Nature 2007) 3 46 64
Products for INS-IGF2 Gene
- Browse R&D Systems for Antibodies
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping cDNA ORF clone for INS-IGF2 in any vector
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- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for INS-IGF2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ViGene Biosciences adenoviral particle packaged cDNA for INS-IGF2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for INS-IGF2 gene
- Search ViGene Biosciences for INS-IGF2
- Horizon Cell Lines for INS-IGF2
- Cyagen custom Knockout/knockin (KOKI) mouse models for INS-IGF2
- VectorBuilder custom plasmid, inducible vectors for INS-IGF2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for INS-IGF2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for INS-IGF2 Gene
- (1) GeneCards
- (2) HGNC
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- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
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- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
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