Aliases for INS-IGF2 Gene
Aliases for INS-IGF2 Gene
External Ids for INS-IGF2 Gene
- HGNC: 33527
- Entrez Gene: 723961
- Ensembl: ENSG00000129965
- UniProtKB: F8WCM5
Previous GeneCards Identifiers for INS-IGF2 Gene
- GC11U900700
- GC11M002124
- GC11M002116
- GC11M002119
- GC11M002120
- GC11M001940
- GC11M002171
- GC11M002131
- GC11M002132
- GC11M002133
- GC11M002135
- GC11M002142
- GC11M002143
- GC11M002147
Summaries for INS-IGF2 Gene
-
This locus includes two alternatively spliced read-through transcript variants which align to the INS gene in the 5' region and to the IGF2 gene in the 3' region. One transcript is predicted to encode a protein which shares the N-terminus with the INS protein but has a distinct and longer C-terminus, whereas the other transcript is a candidate for nonsense-mediated decay (NMD). The transcripts are imprinted and are paternally expressed in the limb and eye. [provided by RefSeq, Jul 2008]
GeneCards Summary for INS-IGF2 Gene
INS-IGF2 (INS-IGF2 Readthrough) is a Protein Coding gene. Diseases associated with INS-IGF2 include Type 1 Diabetes Mellitus 2 and Beckwith-Wiedemann Syndrome. Among its related pathways are Type II diabetes mellitus and AMP-activated Protein Kinase (AMPK) Signaling. Gene Ontology (GO) annotations related to this gene include hormone activity. An important paralog of this gene is INS.
Additional gene information for INS-IGF2 Gene
- Monarch Initiative
- Search for INS-IGF2 at DataMed
- Search for INS-IGF2 at HumanCyc
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INS-IGF2 Gene
Genomics for INS-IGF2 Gene
GeneHancer (GH) Regulatory Elements for INS-IGF2 Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11I002161 | Promoter/Enhancer | 0.8 | EPDnew dbSUPER | 550.8 | 0.0 | -20 | 0.1 | GLIS1 | INS INS-IGF2 | |
GH11I002186 | Enhancer | 1.1 | Ensembl ENCODE dbSUPER | 11.6 | -25.6 | -25615 | 0.8 | CTCF USF1 ZNF473 ZSCAN4 MAX GLI4 CDC5L RAD21 ZNF776 ZBTB48 | INS INS-IGF2 IGF2 ENSG00000199550 CD81 RPL26P30 OSBPL5 TH MIR4686 GC11M002206 | |
GH11I002026 | Enhancer | 0.4 | ENCODE | 11.4 | +131.6 | 131598 | 6.4 | SCRT2 ZNF16 PRDM4 | ENSG00000240801 MIR483 TH IGF2-AS IGF2 INS INS-IGF2 KRTAP5-5 GC11P002011 GC11M002042 | |
GH11I002158 | Promoter/Enhancer | 1 | EPDnew dbSUPER | 0.8 | +2.8 | 2806 | 0.1 | RXRA MAX HNF4A REST GABPA YY1 | IGF2 INS-IGF2 | |
GH11I002139 | Promoter/Enhancer | 2 | EPDnew FANTOM5 Ensembl ENCODE dbSUPER | 0.4 | +15.1 | 15070 | 13 | ELF3 RB1 MZF1 BATF ZNF48 RAD21 ZEB1 ZNF335 GLIS2 SCRT2 | IGF2 TSSC4 ENSG00000199550 CD81 LSP1 LOC100505570 KRTAP5-6 FAM99B KRTAP5-5 TH |
Regulatory Element Products
Genomic Locations for INS-IGF2 Gene
- chr11:2,129,112-2,161,209
- (GRCh38/hg38)
- Size:
- 32,098 bases
- Orientation:
- Minus strand
- chr11:2,150,342-2,182,439
- (GRCh37/hg19)
Genomic View for INS-IGF2 Gene
- Cytogenetic band:
-
- 11p15.5 by Ensembl
- 11p15.5 by Entrez Gene
- 11p15.5 by HGNC


RefSeq DNA sequence for INS-IGF2 Gene
Proteins for INS-IGF2 Gene
-
Protein details for INS-IGF2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- F8WCM5-INSR2_HUMAN
- Recommended name:
- Insulin, isoform 2
- Protein Accession:
- F8WCM5
- Q1WM24
Protein attributes for INS-IGF2 Gene
- Size:
- 200 amino acids
- Molecular mass:
- 21537 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for INS-IGF2 Gene
Other Protein References for INS-IGF2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for INS-IGF2
- Search GeneTex for Antibodies for INS-IGF2
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for INS-IGF2
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Assay Products
No data available for DME Specific Peptides for INS-IGF2 Gene
Domains & Families for INS-IGF2 Gene
Gene Families for INS-IGF2 Gene
- Human Protein Atlas (HPA):
-
- Predicted secreted proteins
Protein Domains for INS-IGF2 Gene
- InterPro:
- ProtoNet:
Graphical View of Domain Structure for InterPro Entry
No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for INS-IGF2 Gene
Function for INS-IGF2 Gene
Phenotypes From GWAS Catalog for INS-IGF2 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005179 | hormone activity | IEA | -- |
Phenotypes for INS-IGF2 Gene
- GenomeRNAi human phenotypes for INS-IGF2:
Animal Model Products
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-
-
ViGene Biosciences ready-to-package AAV shRNAs for INS-IGF2 gene
- Search ViGene Biosciences for INS-IGF2
CRISPR Products
- Browse CRISPR knockouts for INS-IGF2
- genomics-online: gRNA clones - Search results for 23 available INS-IGF2 gene related products
- Overview of 23 available INS-IGF2 gene related products
- Applied Biological Materials CRISPR for INS-IGF2
-
Vectors and viruses for KO, Activation, Repression, and more
- GenScript: Design CRISPR guide RNA sequences for INS-IGF2
miRNA Products
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Inhibitory RNA Products
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- Overview of 23 available INS-IGF2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for INS-IGF2 gene
Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for INS-IGF2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for INS-IGF2
-
ViGene Biosciences adenoviral particle packaged cDNA for INS-IGF2 gene
-
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No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for INS-IGF2 Gene
Localization for INS-IGF2 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for INS-IGF2 Gene
Pathways & Interactions for INS-IGF2 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | AMP-activated Protein Kinase (AMPK) Signaling | ||
2 | Type II diabetes mellitus |
Pathways by source for INS-IGF2 Gene
2 BioSystems pathways for INS-IGF2 Gene
Interacting Proteins for INS-IGF2 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0010469 | regulation of receptor activity | IEA | -- |
No data available for SIGNOR curated interactions for INS-IGF2 Gene
Transcripts for INS-IGF2 Gene
mRNA/cDNA for INS-IGF2 Gene
- (1) REFSEQ mRNAs :
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for INS-IGF2
- genomics-online: gRNA clones - Search results for 23 available INS-IGF2 gene related products
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-
Vectors and viruses for KO, Activation, Repression, and more
- GenScript: Design CRISPR guide RNA sequences for INS-IGF2
miRNA Products
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Inhibitory RNA Products
- genomics-online: shRNA clones - Search results for 23 available INS-IGF2 gene related products
- Overview of 23 available INS-IGF2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for INS-IGF2 gene
Clone Products
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- VectorBuilder custom plasmid, inducible vectors for INS-IGF2
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for INS-IGF2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for INS-IGF2 Gene
mRNA differential expression in normal tissues according to GTEx for INS-IGF2 Gene
mRNA Expression by UniProt/SwissProt for INS-IGF2 Gene:
F8WCM5-INSR2_HUMANEvidence on tissue expression from TISSUES for INS-IGF2 Gene
- Pancreas(3)
Primer Products
- genomics-online: primer clones - Search results for 23 available INS-IGF2 gene related products
- Overview of 23 available INS-IGF2 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for INS-IGF2 Gene
Orthologs for INS-IGF2 Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
dog (Canis familiaris) |
Mammalia | INS 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | INS 34 |
|
OneToMany | |
lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
zebrafish (Danio rerio) |
Actinopterygii | ins 34 |
|
ManyToMany | |
insb 34 |
|
ManyToMany |
- Species where no ortholog for INS-IGF2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for INS-IGF2 Gene
(1) SIMAP similar genes for INS-IGF2 Gene using alignment to 1 proteins:
Variants for INS-IGF2 Gene
SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1005492220 | uncertain-significance, Transient Neonatal Diabetes, Dominant/Recessive, Maturity-onset diabetes of the young | 2,161,165(-) | G/C | intron_variant | |
rs1057524907 | likely-pathogenic, Monogenic diabetes | 2,159,907(-) | T/C | intron_variant | |
rs1064794050 | pathogenic, not provided, Russell-Silver syndrome | 2,135,446(-) | G/C | genic_downstream_transcript_variant, non_coding_transcript_variant | |
rs121908259 | not-provided, Maturity-onset diabetes of the young, type 10 | 2,160,955(-) | C/T | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
rs121908260 | pathogenic, Maturity-onset diabetes of the young, type 10 | 2,160,835(-) | C/T | coding_sequence_variant, missense_variant, non_coding_transcript_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1566n54 | CNV | loss | 21841781 |
dgv1567n54 | CNV | loss | 21841781 |
dgv551e59 | CNV | duplication | 20981092 |
esv2673506 | CNV | deletion | 23128226 |
nsv1070426 | CNV | deletion | 25765185 |
nsv1118203 | CNV | deletion | 24896259 |
nsv467645 | CNV | gain | 19166990 |
nsv553047 | CNV | gain | 21841781 |
nsv553068 | CNV | loss | 21841781 |
nsv553069 | CNV | loss | 21841781 |
nsv553070 | CNV | loss | 21841781 |
nsv553071 | CNV | gain | 21841781 |
nsv553076 | CNV | loss | 21841781 |
nsv553077 | CNV | loss | 21841781 |
nsv553078 | CNV | loss | 21841781 |
nsv825707 | CNV | gain | 20364138 |
nsv951284 | CNV | deletion | 24416366 |
Additional Variant Information for INS-IGF2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INS-IGF2 Gene
Disorders for INS-IGF2 Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
type 1 diabetes mellitus 2 |
|
|
beckwith-wiedemann syndrome |
|
|
Additional Disease Information for INS-IGF2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for INS-IGF2 Gene
Publications for INS-IGF2 Gene
- Imprinting of IGF2 P0 transcript and novel alternatively spliced INS-IGF2 isoforms show differences between mouse and human. (PMID: 16531418) Monk D … Moore GE (Human molecular genetics 2006) 2 3 4 58
- Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. (PMID: 21829393) Plagnol V … Todd JA (PLoS genetics 2011) 3 44 58
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
- A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene. (PMID: 17632545) Hakonarson H … Polychronakos C (Nature 2007) 3 44 58
- Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. (PMID: 17554260) Todd JA … Clayton DG (Nature genetics 2007) 3 44 58
Products for INS-IGF2 Gene
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for INS-IGF2
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- ViGene Biosciences adenoviral particle packaged cDNA for INS-IGF2 gene
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- Overview of 23 available INS-IGF2 gene related products
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- Overview of 23 available INS-IGF2 gene related products
- genomics-online: shRNA clones - Search results for 23 available INS-IGF2 gene related products
- Overview of 23 available INS-IGF2 gene related products
Sources for INS-IGF2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
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- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
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- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
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- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
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- (135) Horizon
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- (138) Cyagen
- (139) VectorBuilder
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- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew