INS-IGF2 Gene

Aliases
for INS-IGF2 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC11U900700 GC11M002124 GC11M002116 GC11M002119 GC11M002120 GC11M001940

Summaries
for INS-IGF2 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for INS-IGF2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Browse SwitchGear Promoter luciferase reporter plasmids

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat INS-IGF2

INS-IGF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M002171:  view genomic region     (about GC identifiers)

Proteins
for INS-IGF2 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for INS-IGF2: NX_F8WCM5

Explore proteomics data for INS-IGF2 at MOPED


See INS-IGF2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

INS-IGF2 Human Recombinant Protein Products:

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	antibodies-online antibodies for INS-IGF2

INS-IGF2 Assay Products:

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	Search antibodies-online for kits for INS-IGF2

Domains /
Families
for INS-IGF2 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: F8WCM5

Function
for INS-IGF2 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 1 molecular function term:    About this table

genOway: Develop your customized and physiologically relevant rodent model for INS-IGF2

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		Predesigned siRNA for gene silencing in human, mouse, rat INS-IGF2

Gene Editing Products:

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INS-IGF2

Localization
for INS-IGF2 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): 1 cellular component term:    About this table

Pathways & Interactions
for INS-IGF2 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Drugs & Compounds
for INS-IGF2 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for INS-IGF2 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for INS-IGF2 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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INS-IGF2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for INS-IGF2
		Pre-validated RT2 qPCR Primer Assay in human, mouse / rat INS-IGF2
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INS-IGF2

Orthologs
for INS-IGF2 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for INS-IGF2 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for INS-IGF2 gene

INS²  

1 SIMAP similar gene for INS-IGF2 using alignment to 1 protein entry:     INSR2_HUMAN:

INS

Find genes that share paralogs with INS-IGF2           About GenesLikeMe

Genomic Variants
for INS-IGF2 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for INS-IGF2 (see all 131)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs178831311,2	C,F	--	2173086(+)	GGGCTG/ATGGCC	2	--	int1		3		NS WA	204
rs1511449231,2		--	2173121(+)	CCTAAA/GCCACA	2	--	int1		0	--	--	--	--
rs1402627291,2		--	2173325(+)	CACCCA/GGCTCC	2	--	int1		0	--	--	--	--
rs1485445311,2	C	--	2173411(+)	TTCAG-/AAAAAAGC	2	--	cds1 int1		0	--	--	--	--
rs79243161,2	C,F,A,H	--	2173447(+)	GACCGT/GAGCTA	2	--	int1		37		NS EA NA WA CSA	4441
rs792518841,2	F	--	2173537(+)	TGGCCC/ACAGAG	2	--	int1		1		WA	118
rs1926300131,2		--	2173627(+)	CAGCCC/TGAGGG	2	--	int1		0	--	--	--	--
rs766414801,2	C	--	2173907(+)	CCACAG/TGTCCA	2	--	int1		0	--	--	--	--
rs797619711,2	C	--	2173908(+)	CACAGC/GTCCAC	2	--	int1		0	--	--	--	--
rs1854621541,2		--	2174090(+)	CAAGAC/GTCTCA	2	--	int1		0	--	--	--	--

HapMap Linkage Disequilibrium report for INS-IGF2 (2150342 - 2182439 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for INS-IGF2 (see all 17):    About this table    

Variant ID	Type	Subtype	PubMed ID
esv2673506	CNV	Deletion	23128226
dgv996n71	CNV	Loss	21882294
nsv896776	CNV	Loss	21882294
nsv896785	CNV	Loss	21882294
dgv994n71	CNV	Loss	21882294
nsv896796	CNV	Loss	21882294
dgv998n71	CNV	Loss	21882294
dgv995n71	CNV	Loss	21882294
nsv896798	CNV	Loss	21882294
nsv896797	CNV	Loss	21882294

Site Specific Mutation Identification with PCR Assays

Search QIAGEN SeqTarget long-range PCR primers for resequencing INS-IGF2

DNA2.0 Custom Variant and Variant Library Synthesis for INS-IGF2

Disorders / Diseases
for INS-IGF2 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for INS-IGF2 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Imprinting of IGF2 P0 transcript and novel alternatively spliced INS- IGF2 isoforms show differences between mouse and human. (PubMed id 16531418)^{1, 2, 3} Monk D.... Moore G.E. (Hum. Mol. Genet. 2006)
2. Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. (PubMed id 21829393)^{1, 4} Plagnol V....Todd J.A. (PLoS Genet. 2011)
3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (Diabetes Care 2010)
4. A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene. (PubMed id 17632545)^{1, 4} Hakonarson H.... Polychronakos C. (Nature 2007)
5. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. (PubMed id 17554260)^{1, 4} Todd J.A.... Clayton D.G. (Nat. Genet. 2007)
6. Autoimmunity against INS-IGF2 protein expressed in human pancreatic islets. (PubMed id 23935095)¹ Kanatsuna N....Lernmark A.8. (J. Biol. Chem. 2013)
7. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)¹ Prakash T....Taylor T.D. (PLoS ONE 2010)
8. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)¹ Talmud P.J.... . (Am. J. Hum. Genet. 2009)
9. Association between small for gestational age and paternally inherited 5' insulin haplotypes. (PubMed id 17700581)¹ Adkins R.M....Somes G. (Int J Obes (Lond) 2008)
10. Association between paternally inherited haplotypes upstream of the insulin gene and umbilical cord IGF-II levels. (PubMed id 17667841)¹ Adkins R.M....Morrison J.C. (Pediatr. Res. 2007)

External Searches for INS-IGF2 gene

Genome Databases showing INS-IGF2 gene

Other Databases showing INS-IGF2 gene

Specialized Databases showing INS-IGF2 gene

Products
for INS-IGF2 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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