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INS Gene

protein-coding GIFtS: 66

GC11M002125

insulin
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ILPR ^²
IRDN ^²
OTTHUMP00000011161 ^²
OTTHUMP00000011162 ^²
OTTHUMP00000196038 ^²
insulin ^²
proinsulin ^²

External Ids
HGNC: 6081¹
Entrez Gene: 3630²
UniProtKB: P01308³
Ensembl: ENSG00000129965⁷

Search outside databases for aliases for INS gene

Previous GC identifers: GC11U990070 GC11M002268 GC11M002140 GC11M002145 GC11M002137 GC11M002106

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for INS:

After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into two

chains (peptide A and peptide B) that are covalently linked via two disulfide bonds. Binding of

this mature form of insulin to the insulin receptor (INSR) stimulates glucose uptake. A variety of

mutant alleles with changes in the coding region have been identified. There is a read-through

gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the

3' region. [provided by RefSeq]

UniProtKB/Swiss-Prot: INS_HUMAN, P01308

Function: Insulin decreases blood glucose concentration. It increases cell permeability to

monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate

cycle, and glycogen synthesis in liver

Gene Wiki entry for INS (Insulin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the INS gene

Entrez Gene cytogenetic band: 11p15.5 Ensembl cytogenetic band: 11p15.5 HGNC cytogenetic band: 11p15.5

INS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M002125: (about GC identifiers)

Start:	2,124,432 bp from pter
End:	2,139,027 bp from pter
Size:	14,596 bases
Orientation:	minus strand

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: INS_HUMAN, P01308 (See protein sequence)

Recommended Name: Insulin precursor

Size: 110 amino acids; 11981 Da

Subunit: Heterodimer of a B chain and an A chain linked by two disulfide bonds

Subcellular location: Secreted

Sequence caution: Sequence=AAA59179.1; Type=Erroneous gene model prediction;

PDB structures from and Proteopedia :

1A7F (3D)

1AI0 (3D)

1AIY (3D)

1B9E (3D)

1BEN (3D)

1EFE (3D)

1EV3 (3D)

1EV6 (3D)

1EVR (3D)

1FU2 (3D)

1FUB (3D)

1G7A (3D)

1G7B (3D)

1GUJ (3D)

1HIQ (3D)

1HIS (3D)

1HIT (3D)

1HLS (3D)

1HTV (3D)

1HUI (3D)

1IOG (3D)

1IOH (3D)

1J73 (3D)

1JCA (3D)

1JCO (3D)

1K3M (3D)

1KMF (3D)

1LKQ (3D)

1LPH (3D)

1MHI (3D)

1MHJ (3D)

1MSO (3D)

1OS3 (3D)

1OS4 (3D)

1Q4V (3D)

1QIY (3D)

1QIZ (3D)

1QJ0 (3D)

1RWE (3D)

1SF1 (3D)

1SJT (3D)

1SJU (3D)

1T0C (3D)

1T1K (3D)

1T1P (3D)

1T1Q (3D)

1TRZ (3D)

1TYL (3D)

1TYM (3D)

1UZ9 (3D)

1VKT (3D)

1W8P (3D)

1XDA (3D)

1XGL (3D)

1XW7 (3D)

1ZEG (3D)

1ZEH (3D)

1ZNJ (3D)

2AIY (3D)

2C8Q (3D)

2C8R (3D)

2CEU (3D)

2G54 (3D)

2H67 (3D)

2HH4 (3D)

2HHO (3D)

2HIU (3D)

2JMN (3D)

2JUM (3D)

2JUU (3D)

2JUV (3D)

2JV1 (3D)

2JZQ (3D)

2K91 (3D)

2K9R (3D)

2OLY (3D)

2OLZ (3D)

2OM0 (3D)

2OM1 (3D)

2OMG (3D)

2OMH (3D)

2OMI (3D)

2QIU (3D)

2R34 (3D)

2R35 (3D)

2R36 (3D)

2RN5 (3D)

2VJZ (3D)

2VK0 (3D)

2WBY (3D)

2WC0 (3D)

3AIY (3D)

3BRR (3D)

3BXQ (3D)

3E7Y (3D)

3E7Z (3D)

4AIY (3D)

5AIY (3D)

Secondary accessions: Q5EEX2

REFSEQ proteins: NP_000198.1

ENSEMBL proteins:

ENSP00000380432 ENSP00000250971 ENSP00000370720 ENSP00000380440 ENSP00000370731

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant INS Protein
	Sigma-Aldrich Proteins for INS
	R&D Systems Recombinant & Natural Proteins for INS (Proinsulin)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Insulin + Proinsulin, Insulin, C Peptide, Proinsulin)
	Human Recombinant Proteins from Abnova (proinsulin / INS)

OriGene Purified Recombinant Human Protein: INS

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IC	7556975
GO:0005615	extracellular space	IDA	9667398
GO:0005813	centrosome	IDA	18029348

About this table

Antibodies for INS:

	Invitrogen Antibodies for INS
	Millipore Mono- and Polyclonal Antibodies for the study of INS
	Sigma-Aldrich Antibodies for INS
	R&D Systems Antibodies for INS (Proinsulin, Insulin)
	Cell Signaling Technology (CST) Antibodies for INS (Insulin, C-Peptide)
	Antibodies from Abcam (Insulin + Proinsulin, Insulin, C Peptide, Proinsulin), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (proinsulin / INS)
	Novus Biologicals Antibodies for INS

Assays for INS:

	Invitrogen Assays for INS
	Millipore Kits and Assays for the Analysis of INS
	R&D Systems ELISAs for INS (Proinsulin) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P01308

ProtoNet protein and cluster: P01308

1 Blocks protein family: IPB004825 Insulin/IGF/relaxin

UniProtKB/Swiss-Prot: INS_HUMAN, P01308

Similarity: Belongs to the insulin family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (INS)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000207

Applied Biosystems Silencer® siRNAs for INS

Sigma-Aldrich siRNA for INS

Sigma-Aldrich shRNA Panels and shRNA for INS

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for INS
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000207
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000207
untagged cDNA clones in CMV expression vector (see all 2): BC005255

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: BC005255

UniProtKB/Swiss-Prot: INS_HUMAN, P01308

Function: Insulin decreases blood glucose concentration. It increases cell permeability to

monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate

cycle, and glycogen synthesis in liver

Genatlas biochemistry entry for INS:

insulin

15/21 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Ins2) (see all 21 ):

	adipose tissue	behavior/neurological	cellular	digestive/alimentary
embryogenesis	endocrine/exocrine gland	growth/size	hematopoietic system	homeostasis/metabolism
immune system	lethality-postnatal	life span-post-weaning/aging	liver/biliary system	nervous system

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005158	insulin receptor binding	IDA	7556975
GO:0005159	insulin-like growth factor receptor binding	IPI	8452530
GO:0005179	hormone activity	NAS	14986111
GO:0005515	protein binding	IPI	9773776
GO:0005520	insulin-like growth factor binding	IPI	9388210

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/14 Sigma-Aldrich "Your Favorite Gene" Pathways for INS (Your Favorite Gene powered by Ingenuity) (see all 14 )

Type I Diabetes Mellitus Signaling
Hepatic Cholestasis
PPAR&alpha
PPAR Signaling
Insulin Receptor Signaling

GeneDecks INS for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for INS

5/542 Interacting proteins for INS (ENSP00000370731³ P01308²) via UniProtKB, MINT, and/or STRING (see all 542 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
INS	P01308²	MINT-25025 MINT-25072
AKT1	ENSP00000270202³	STRING (score=.999)
IGF1R	ENSP00000268035³	STRING (score=.999)
INSR	ENSP00000303830³	STRING (score=.999)
IRS1	ENSP00000304895³	STRING (score=.999)

About this table

5/45 Gene Ontology (GO) biological process terms (links to tree view) (see all 45 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000165	MAPKKK cascade	IDA	11278339
GO:0005975	carbohydrate metabolic process	IEA	--
GO:0006006	glucose metabolic process	TAS	381941
GO:0006469	negative regulation of protein kinase activity	TAS	8524413
GO:0006521	regulation of amino acid metabolic process	IMP	3553851

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for INS

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for INS
UniProtKB/Swiss-Prot: INS_HUMAN, P01308

Pharmaceutical: Available under the names Humulin or Humalog (Eli Lilly) and Novolin (Novo

Nordisk). Used in the treatment of diabetes. Humalog is an insulin analog with 52-Lys-Pro-53

instead of 52-Pro-Lys-53

10/28 Novoseek chemical compound relationships for INS gene (see all 28 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
glucose	98.08	66619	14694215 (12), 8243832 (10), 17224332 (10), 8156098 (10) (see all 99)
c-peptide	96.00	5861	15375153 (9), 15640407 (8), 16510765 (8), 12831633 (7) (see all 99)
cholesterol	89.67	5500	14636288 (8), 14657199 (8), 8243874 (8), 10673252 (7) (see all 99)
sulfonylurea	88.65	992	1828656 (7), 8591697 (6), 2209344 (5), 8077888 (5) (see all 99)
lipid	87.70	5188	15759111 (7), 18460913 (6), 10491752 (6), 15985488 (6) (see all 99)
incretin	86.43	297	16478775 (4), 11522713 (3), 19375579 (3), 12788877 (3) (see all 99)
fatty acid	83.26	1873	16788709 (6), 1843205 (6), 15767857 (5), 8405699 (5) (see all 99)
glycogen	81.40	1563	11055555 (9), 12823547 (9), 10488084 (8), 8168540 (7) (see all 99)
fructosamine	78.45	168	2256715 (4), 19011281 (3), 7989622 (3), 9088767 (2) (see all 99)
nash	76.62	210	18459024 (6), 15106708 (5), 16198620 (4), 11266382 (4) (see all 99)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (INS)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000207

Sigma-Aldrich siRNA for INS

Sigma-Aldrich shRNA Panels and shRNA for INS

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000207

REFSEQ mRNAs for INS gene:

NM_000207.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000207

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000207
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000207
                                 untagged cDNA clones in CMV expression vector (see all 2): BC005255

24/90 AceView cDNA sequences (see all 90 ):

BQ267595 BQ614588 BM314026 BQ128023 BM565484 BQ267265 BM505656 AW583768

BQ267325 BQ128309 BI710887 BM310312 BQ267174 BM309996 BU788191 BU070644

BM310121 BM894193 BM505453 BM313817 BM565510 BU077500 BM504254 BQ272154

highest scoring ESTs for INS:

BI834604 AW583476 AW583977 BM272195 BM312177 BM312258 BM312616 BM509310 BM894193 BQ272071

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for INS (see all 6 )

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4a	·	4b	·	4c	·	4d
SP1:
SP2:							-
SP3:							-				-
SP4:							-				-		-
SP5:

About this scheme

ECgene alternative splicing isoforms for INS

5 Ensembl transcripts including schematic representations:

ENST00000397262 ENST00000250971 ENST00000381319 ENST00000397270 ENST00000381330

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

INS expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for INS

¹ / ² / ³

3 probe-sets matching INS gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
160038_s_at²^{, 3}	U95-A	2	1.00	0.66	1.00	1.00	J00268	0.20	1.00	0.72	1
206598_at²^{, 3}	U133-A	2	1.00	0.77	--	--	NM_000207	0.40	0.67	0.55	1
206598_at²	U133Plus2	2	1.00	0.77	--	--	--	--	--	--	--

GeneDecks INS for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTTGGGTTTT
Expression variation in blood from EXPOLDB for INS

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for INS gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	INS¹	--	insulin	86.06(n) 88.18(a)	483665 XM_540786.2 XP_540786.1
chimpanzee (Pan troglodytes)	INS¹	--	insulin	98.18(n) 98.18(a)	449570 NM_001008996.1 NP_001008996.1
cow (Bos taurus)	INS¹	--	insulin	83.17(n) 83.81(a)	280829 NM_173926.1 NP_776351.1
rat (Rattus norvegicus)	Ins2¹	--	insulin 2	80.91(n) 82.73(a)	24506 NM_019130.1 NP_062003.1
mouse (Mus musculus)	Ins2^{1, 5}	7 (69.10 cM)⁵	insulin II^{1, 5}	82.42(n)¹ 81.82(a)¹	16334¹ NM_008387.3¹ NP_032413.1¹ AA986540⁵ AK007612⁵ (see all 14)

About this table Species with no ortholog for INS

ENSEMBL Gene Tree for INS

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 176730

UniProtKB/Swiss-Prot: INS_HUMAN, P01308

Defects in INS are the cause of familial hyperproinsulinemia [MIM:176730]

10/95 Novoseek disease relationships for INS gene (see all 95 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
insulin resistance	98.95	57490	15209435 (13), 16489319 (13), 17588192 (12), 17259468 (12) (see all 99)
insulin sensitivity	97.92	27655	8174845 (11), 9797852 (11), 11079822 (10), 14506625 (10) (see all 99)
diabetes mellitus insulin-dependent	97.16	9460	2004172 (7), 9551692 (7), 1756017 (7), 7970366 (7) (see all 99)
niddm	96.28	8134	10996359 (9), 9538982 (9), 9715376 (9), 10421979 (8) (see all 99)
hyperinsulinemia	96.08	4169	16489319 (10), 7700881 (7), 8576790 (6), 18060751 (6) (see all 99)
obesity	95.04	8916	14694215 (8), 18457598 (7), 9869004 (7), 16353333 (7) (see all 99)
hypoglycemia	94.94	4722	10975210 (8), 9162611 (8), 18484562 (8), 11544612 (8) (see all 99)
hyperglycemia	94.62	3862	1452531 (6), 2272633 (5), 18596634 (5), 1727733 (5) (see all 99)
diabetes mellitus	93.65	3787	1357169 (6), 9509457 (5), 8913409 (5), 1966582 (4) (see all 99)
impaired glucose tolerance	93.58	1300	8462385 (6), 8609839 (5), 2075783 (4), 8088119 (4) (see all 99)

About this table

Genatlas disease: INS

diabetes,with hyperproinsulinemia,putative susceptibility factor for obesity in association with

IgF2 in British population

GeneTests: INS

Permanent Neonatal Diabetes Mellitus

Human Gene Mutation Database: INS
Genetic Association Database: INS
Human Genome Epidemiology Navigator: INS (316 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/10681 PubMed articles for INS gene (see all 10681 ):

Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR. (PubMed id 8358440)^{3, 4, 6} Lucassen A.M.... Bell J.I. (1993)
A mutation in the B chain coding region is associated with impaired proinsulin conversion in a family with hyperproinsulinemia. (PubMed id 3470784)^{3, 4, 6} Chan S.J.... Steiner D.F. (1987)
Sequence of the human insulin gene. (PubMed id 6243748)^{2, 3, 4} Bell G.I....Goodman H.M. (1980)
Insulinomas and expression of an insulin splice variant. (PubMed id 15070567)^{1, 3, 4} Minn A.H.... Shalev A. (2004)
Genotypic and phenotypic differences between Arabian and Scandinavian women with gestational diabetes mellitus. (PubMed id 15095040)^{1, 3, 6} Shaat N....Groop L. (2004)
Prostate cancer risk and IRS1, IRS2, IGF1, and INS polymorphisms: strong association of IRS1 G972R variant and cancer risk. (PubMed id 15678496)^{1, 3, 6} Neuhausen S.L....Brothman A.R. (2005)
Polymorphisms in candidate genes for type 2 diabetes mellitus in a Mexican population with metabolic syndrome findings. (PubMed id 14693412)^{1, 3, 6} Sanchez-Corona J....Hanson R.L. (2004)
Polymorphism of the insulin gene is associated with increased prostate cancer risk. (PubMed id 12610512)^{1, 3, 6} Ho G.Y....Chua S.C. (2003)
Genetic effects on age-dependent onset and islet cell autoantibody markers in type 1 diabetes. (PubMed id 11978629)^{1, 3, 6} Graham J.... . (2002)
Replication of IGF2-INS-TH*5 haplotype effect on obesity in older men and study of related phenotypes. (PubMed id 16251897)^{3, 6} Rodriguez S....Day I.N. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3630	HGNC: 6081	AceView: INS	Ensembl:ENSG00000129965	euGenes: HUgn3630
ECgene: INS	H-InvDB: INS

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
GeneReviews	http://www.genetests.org/query?gene=INS
Insulin at Eli Lilly	http://www.lillyDiabetes.com/Products/PatientInfo.cfm
Protein Spotlight	http://www.expasy.org/spotlight/back_issues/sptlt009.shtml
Wikipedia	http://en.wikipedia.org/wiki/Insulin

Licensable Technologies for INS
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for INS:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for INS-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for INS		Antibodies for INS
	Explore super-pooled esiRNAs		Proteins for INS
	Lentivirus-delivered shRNAs for INS		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (proinsulin / INS)
	Antibodies (proinsulin / INS)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for INS (Insulin, C-Peptide)

	Recombinant Proteins (Insulin + Proinsulin, Insulin, C Peptide, Proinsulin)
	Antibodies (Insulin + Proinsulin, Insulin, C Peptide, Proinsulin)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for INS

	Drugs for INS
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for INS

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
INS Gene at Home site.
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INS Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for INS

Summaries
for INS

Genomic Location
for INS

Proteins
for INS

Protein Domains/
Families
for INS

Gene Function
for INS

Pathways & Interactions
for INS

Drugs & Compounds
for INS

Transcripts
for INS

Expression
for INS

Orthologs
for INS

Paralogs
for INS

SNPs/Variants
for INS

Disorders & Mutations
for INS

Medical News
for INS

Publications
for INS

Search for INS

Genome Databases showing INS

Other Databases showing INS

Specialized Databases showing INS

Licensable Technologies
for INS

Services
for INS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

INS Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor INS

Summariesfor INS

Genomic Locationfor INS

Proteinsfor INS

Protein Domains/Familiesfor INS

Gene Functionfor INS

Pathways & Interactionsfor INS

Drugs & Compoundsfor INS

Transcriptsfor INS

Expression for INS

Orthologsfor INS

Paralogsfor INS

SNPs/Variantsfor INS

Disorders & Mutationsfor INS

Medical Newsfor INS

Publicationsfor INS

Search for INS

Genome Databases showing INS

Other Databases showing INS

Specialized Databases showing INS

Licensable Technologiesfor INS

Servicesfor INS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for INS

Summaries
for INS

Genomic Location
for INS

Proteins
for INS

Protein Domains/
Families
for INS

Gene Function
for INS

Pathways & Interactions
for INS

Drugs & Compounds
for INS

Transcripts
for INS

Expression
for INS

Orthologs
for INS

Paralogs
for INS

SNPs/Variants
for INS

Disorders & Mutations
for INS

Medical News
for INS

Publications
for INS

Licensable Technologies
for INS

Services
for INS