Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



INS Gene

protein-coding   GIFtS: 62
GCID: GC11M002181

Insulin

(Previous name: insulin-dependent diabetes mellitus 2)
(Previous symbols: IDDM2, IDDM1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
insulin1 2     ILPR2
IDDM21 2 5     IRDN2
IDDM11 2     preproinsulin2
Insulin-Dependent Diabetes Mellitus 21 2     proinsulin2
MODY102 5     

External Ids:    HGNC: 60811   Entrez Gene: 36302   Ensembl: ENSG000002546477   OMIM: 1767305   UniProtKB: P013083   

Export aliases for INS gene to outside databases

Previous GC identifers: GC11U990070 GC11M002268 GC11M002140 GC11M002145 GC11M002137 GC11M002106 GC11M002125 GC11M002153 GC11M001971


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for INS Gene:
After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the
B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide.
Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with
phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at
the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript
variants. (provided by RefSeq, Jun 2010)

GeneCards Summary for INS Gene:
INS (insulin) is a protein-coding gene. Diseases associated with INS include insulin autoimmune syndrome, and diabetes mellitus, insulin-dependent, 2. GO annotations related to this gene include protease binding and identical protein binding. An important paralog of this gene is INS-IGF2.

UniProtKB/Swiss-Prot: INS_HUMAN, P01308
Function: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino
acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver

Gene Wiki entry for INS (Insulin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the INS gene promoter:
         GR   CREB   AP-1   deltaCREB   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): INS promoter sequence
   Search Chromatin IP Primers for INS

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat INS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

INS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INS gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M002181:  view genomic region     (about GC identifiers)

Start:
2,181,009 bp from pter      End:
2,182,571 bp from pter
Size:
1,563 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: INS_HUMAN, P01308 (See protein sequence)
Recommended Name: Insulin precursor  
Size: 110 amino acids; 11981 Da
Subunit: Heterodimer of a B chain and an A chain linked by two disulfide bonds
Sequence caution: Sequence=AAA59179.1; Type=Erroneous gene model prediction;
Selected PDB 3D structures from and Proteopedia for INS (see all 192):
1A7F (3D)        1AI0 (3D)        1AIY (3D)        1B9E (3D)        1BEN (3D)        1EFE (3D)    
Secondary accessions: Q5EEX2
Alternative splicing: 2 isoforms:  P01308-1   F8WCM5-1   (Based on a readthrough transcript which may produce an INS-IGF2 fusion protein)

Explore the universe of human proteins at neXtProt for INS: NX_P01308

REFSEQ proteins (3 alternative transcripts): 
NP_000198.1  NP_001172026.1  NP_001172027.1  

ENSEMBL proteins: 
 ENSP00000380432   ENSP00000250971   ENSP00000370731   ENSP00000408400   ENSP00000424008  
Reactome Protein details: P01308

INS Human Recombinant Protein Products:

EMD Millipore Purified and/or Recombinant INS Protein
R&D Systems Recombinant & Natural Proteins for INS (Proinsulin)
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein for INS
OriGene Protein Over-expression Lysate for INS
OriGene MassSpec for INS
OriGene Custom Protein Services for INS
GenScript Custom Purified and Recombinant Proteins Services for INS
Novus Biologicals INS Proteins
Novus Biologicals INS Lysate
Sino Biological Recombinant Protein for INS
Browse Sino Biological Cell Lysates
ProSpec Recombinant Protein for INS
Cloud-Clone Corp. Proteins for INS

INS Antibody Products:

EMD Millipore Mono- and Polyclonal Antibodies for the study of INS
R&D Systems Antibodies for INS (Proinsulin, Insulin)
Cell Signaling Technology (CST) Antibodies for INS  (insulin)
OriGene Antibodies for INS
OriGene Custom Antibody Services for INS
Novus Biologicals INS Antibodies
Abcam antibodies for INS
Cloud-Clone Corp. Antibodies for INS
ThermoFisher Antibody for INS
LSBio Antibodies in human, mouse, rat for INS

INS Assay Products:

EMD Millipore Kits and Assays for the Analysis of INS
OriGene Custom Assay Services for INS
R&D Systems ELISAs for INS (Proinsulin, Insulin)         (see all)
GenScript Custom Assay Services for INS
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for INS
Cloud-Clone Corp. CLIAs for INS


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
4 InterPro protein domains:
 IPR016179 Insulin-like
 IPR022352 Insulin_family
 IPR022353 Insulin_CS
 IPR004825 Insulin

Graphical View of Domain Structure for InterPro Entry P01308

ProtoNet protein and cluster: P01308

1 Blocks protein domain: IPB004825 Insulin/IGF/relaxin

UniProtKB/Swiss-Prot: INS_HUMAN, P01308
Similarity: Belongs to the insulin family


INS for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: INS_HUMAN, P01308
Function: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino
acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver

     Genatlas biochemistry entry for INS:
insulin

     Summary: 
During embryonic development, INS as signaling molecule affects the following cells:
Adipose: Subcutaneous White Preadipocytes (Body Subcutaneous White Adipose)

INS as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
      selected tissues (see all 9)      fully expand
Adipose: Adipocyte-like cells (Mm), Brown adipocyte-like cells      fully expand to see all 4 cells
Spinal Cord: Motor neuron progenitor cells, Oligodendrocyte progenitor-like cells      fully expand to see all 2 cells

     Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0002020protease binding IPI--
GO:0005158insulin receptor binding IPI8452530
GO:0005159insulin-like growth factor receptor binding IPI8452530
GO:0005179hormone activity NAS14986111
GO:0005515protein binding IPI9388210
     
INS for ontologies           About GeneDecksing


Phenotypes:
     2 GenomeRNAi human phenotypes for INS:
 Increased cell death in HCC-19  Increased cell death in breast 

     Selected MGI mutant phenotypes (inferred from 13 alleles(MGI details for Ins2) (see all 22):
 adipose tissue  behavior/neurological  cardiovascular system  cellular  digestive/alimentary 
 embryogenesis  endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism 
 immune system  integument  liver/biliary system  mortality/aging  muscle 

INS for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-outs for INS: Ins2tm2Jja Ins2tm1.1Mnt

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for INS
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for INS

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for INS
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for INS

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat INS using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate INS
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for INS
Predesigned siRNA for gene silencing in human, mouse, rat INS

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for INS

Clone
Products:
     
OriGene clones in human, mouse for INS (see all 8)
OriGene ORF clones in mouse, rat for INS
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 3): INS (NM_000207)
Sino Biological Human cDNA Clone for INS
DNA2.0 Custom Codon Optimized Gene Synthesis Service for INS
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INS

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for INS
Browse ESI BIO Cell Lines and PureStem Progenitors for INS 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INS


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot
INS_HUMAN, P01308: Secreted
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
endoplasmic reticulum4
endosome4
golgi apparatus4
plasma membrane4
cytoskeleton3
cytosol3
mitochondrion3
nucleus3
peroxisome3
lysosome2
vacuole2

Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005615extracellular space IDA9667398
GO:0005788endoplasmic reticulum lumen TAS--
GO:0005796Golgi lumen TAS--
GO:0031904endosome lumen TAS--

INS for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for INS About   (see all 55)  
See pathways by source

SuperPathContained pathways About
1Translation Insulin regulation of translation
Translation Insulin regulation of translation0.59
Translation Regulation activity of EIF20.47
Regulation of lipid metabolism Insulin signaling generic cascades0.59
mTOR signaling pathway0.34
Transcription Receptor mediated HIF regulation0.51
Insulin signaling pathway0.32
2Regulation of beta-cell development
Regulation of beta-cell development0.64
Maturity onset diabetes of the young0.61
Regulation of gene expression in beta cells0.64
3Type II diabetes mellitus
Type II diabetes mellitus0.38
Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics0.38
4Insulin receptor signalling cascade
Insulin receptor signalling cascade0.94
IRS activation0.00
IRS-related events0.94
SHC activation0.00
Signaling by Insulin receptor0.80
Signal attenuation0.00
SHC-related events0.00
5Peptide hormone metabolism
Peptide hormone metabolism0.30
Synthesis, Secretion, and Deacylation of Ghrelin0.00
Insulin Processing0.30

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 R&D Systems Pathway for INS
    Adipocytokines & Insulin Signaling

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for INS (see all 9)
    eIF2 Pathway
mTOR Pathway
SOCS Pathway
AMPK Enzyme Complex Pathway
p70S6K Signaling

1 Cell Signaling Technology (CST) Pathway for INS
    Glucose / Energy Metabolism

5 GeneGo (Thomson Reuters) Pathways for INS
    Translation Insulin regulation of translation
Transcription Receptor-mediated HIF regulation
Transcription Transcription factor Tubby signaling pathways
Regulation of lipid metabolism Insulin signaling-generic cascades
Translation Regulation of EIF2 activity

Selected BioSystems Pathways for INS (see all 16)
    Senescence and Autophagy
Adipogenesis
SREBP signalling
AGE/RAGE pathway
Cardiac Progenitor Differentiation


Selected Reactome Pathways for INS (see all 9)
    Insulin receptor recycling
Regulation of insulin secretion
Insulin processing
Regulation of gene expression in beta cells
Synthesis, secretion, and deacylation of Ghrelin

1 PharmGKB Pathway for INS
    Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics

Selected Kegg Pathways  (Kegg details for INS) (see all 20):
    Ras signaling pathway
Rap1 signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Oocyte meiosis


INS for pathways           About GeneDecksing

    Pathway & Disease-focused RT2 Profiler PCR Arrays including INS (see all 17): 
          Insulin Signaling Pathway in human mouse rat
          Nitric Oxide Signaling Pathway in human mouse rat
          Autophagy in human mouse rat
          Alzheimer's Disease in human mouse rat
          Cell Lineage Identification in human mouse rat

Interactions:

    GeneGlobe Interaction Network for INS

Selected Interacting proteins for INS (P013081, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
InteractantInteraction Details
GeneCardExternal ID(s)
INSP013081, 2EBI-7090529,EBI-7090529 MINT-25025 MINT-8400034 MINT-8400062 MINT-8413743 MINT-8400091 MINT-8400115 MINT-8413680 MINT-8400105 MINT-8400130 MINT-8400074 MINT-8400048 MINT-25072
MAPK6Q166592, 3MINT-8261296 I2D: score=2 
ENSG00000204276P019063I2D: score=1 
ENSG00000206301P019063I2D: score=1 
ENSG00000223793P019063I2D: score=1 
About this table

Gene Ontology (GO): Selected biological process terms (see all 61):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000165MAPK cascade IDA11278339
GO:0002674negative regulation of acute inflammatory response IDA11443198
GO:0006006glucose metabolic process IEA--
GO:0006112energy reserve metabolic process TAS--
GO:0006355regulation of transcription, DNA-templated NAS12881524

INS for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for INS

UniProtKB/Swiss-Prot: INS_HUMAN, P01308
Pharmaceutical: Available under the names Humulin or Humalog (Eli Lilly) and Novolin (Novo Nordisk). Used in the
treatment of diabetes. Humalog is an insulin analog with 52-Lys-Pro-53 instead of 52-Pro-Lys-53

2 DrugBank Compounds for INS    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
M-Cresol-- 108-39-4target--17139284 17016423 10592235
MYRISTIC ACID-- --target--10592235

Selected Novoseek inferred chemical compound relationships for INS gene (see all 128)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
glucose 98.1 72789 14694215 (12), 8243832 (10), 17224332 (10), 8156098 (10) (see all 99)
c-peptide 96 6299 15375153 (9), 15640407 (8), 16510765 (8), 12831633 (7) (see all 99)
metformin 93.1 3189 16294070 (9), 10928231 (9), 9101010 (8), 18463376 (8) (see all 99)
cholesterol 90.1 6187 14636288 (8), 14657199 (8), 8243874 (8), 10673252 (7) (see all 99)
sulfonylurea 88.7 1046 1828656 (7), 8591697 (6), 2209344 (5), 9454524 (5) (see all 99)
lipid 88.3 5811 15759111 (7), 19897010 (7), 18460913 (6), 15985488 (6) (see all 99)
incretin 87.5 377 16478775 (4), 11522713 (3), 19375579 (3), 12788877 (3) (see all 99)
pioglitazone 86.5 1015 15531002 (9), 19889003 (8), 17587394 (7), 20407626 (7) (see all 99)
rosiglitazone 86 1042 18074413 (7), 16183427 (7), 15504990 (6), 12466369 (5) (see all 99)
fatty acid 83.6 2038 16788709 (6), 1843205 (6), 19782765 (6), 15767857 (5) (see all 99)



INS for compounds           About GeneDecksing



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for INS gene (3 alternative transcripts): 
NM_000207.2  NM_001185097.1  NM_001185098.1  

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000397262(uc021qcd.1) ENST00000250971(uc009ydg.1 uc001lvn.2)
ENST00000381330(uc001lvo.1) ENST00000421783 ENST00000512523
Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
Products:
     
Block miRNA regulation of human, mouse, rat INS using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate INS
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for INS
Predesigned siRNA for gene silencing in human, mouse, rat INS
Clone
Products:
     
OriGene clones in human, mouse for INS (see all 8)
OriGene ORF clones in mouse, rat for INS
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 3): INS (NM_000207)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for INS
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INS
Primer
Products:
    
OriGene qPCR primer pairs and template standards for INS
OriGene qSTAR qPCR primer pairs in human, mouse for INS
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat INS
  QuantiTect SYBR Green Assays in human, mouse, rat INS
  QuantiFast Probe-based Assays in human, mouse, rat INS

Selected AceView cDNA sequences (see all 90):

BU788191 BM565484 BQ549803 BM313837 BU077500 BM313968 BM310184 BQ267325 
BM505453 BM565510 BM505647 BQ478503 BU781809 BQ267331 BQ549793 BM894193 
BM310280 BM509200 BM310128 BU782939 BM313776 BM509210 BT006808 BM313727 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

INS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
INS Expression
About this image


INS expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Pancreas (Endocrine System)    fully expand to see all 20 entries
         Immature Beta Progenitor Cells Ventral Pancreatic Bud
         Islets of Langerhans
         Islet-like cell clusters
         Pancreatic Islet   
 
 NULL (Uncategorized)
         Definitive endoderm-like cells
INS Protein expression data from MOPED1, PaxDb2 and MaxQB3 --
    Pathway & Disease-focused RT2 Profiler PCR Arrays including INS (see all 17): 
          Insulin Signaling Pathway in human mouse rat
          Nitric Oxide Signaling Pathway in human mouse rat
          Autophagy in human mouse rat
          Alzheimer's Disease in human mouse rat
          Cell Lineage Identification in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for INS
OriGene qSTAR qPCR primer pairs in human, mouse for INS
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat INS
QuantiTect SYBR Green Assays in human, mouse, rat INS
QuantiFast Probe-based Assays in human, mouse, rat INS
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INS

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of chordates.

Orthologs for INS gene from Selected species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ins21 , 5 insulin II1, 5 82.42(n)1
81.82(a)1
  7 (88.00 cM)5
163341  NM_008387.41  NP_032413.11 
 1426786565 
chicken
(Gallus gallus)
Aves INS1 insulin 65.42(n)
65.42(a)
  396145  NM_205222.2  NP_990553.1 
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
55(a)
1 → many
1(69965277-69969077)
African clawed frog
(Xenopus laevis)
Amphibia M24442.12   -- 79.94(n)    M24442.1 
zebrafish
(Danio rerio)
Actinopterygii ins2 preproinsulin 74.94(n)   30262  AF036326.1 


ENSEMBL Gene Tree for INS (if available)
TreeFam Gene Tree for INS (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
Paralogs for INS gene
INS-IGF22  
3 SIMAP similar genes for INS using alignment to 5 protein entries:     INS_HUMAN (see all proteins):
INS-IGF2    IGF-I    IGF1

INS for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for INS (see all 27)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1219082731,2,4
Diabetes mellitus, permanent neonatal (PNDM)4--see VAR_0637272 mis40--------
rs1219082611,2,4
Diabetes mellitus, insulin-dependent, 2 (IDDM2)4--see VAR_0637322 mis40--------
rs1219082601,2,4
Maturity-onset diabetes of the young 10 (MODY10)4--see VAR_0637292 mis40--------
VAR_0039754
Hyperproinsulinemia, familial (FHPRI)4--see VAR_0039752 R L mis40--------
rs803566691,2,4
Diabetes mellitus, permanent neonatal (PNDM)4--see VAR_0637352 mis40--------
rs1219082781,2,4
Maturity-onset diabetes of the young 10 (MODY10)4--see VAR_0637212 mis40--------
VAR_0039714
Hyperproinsulinemia, familial (FHPRI)4--see VAR_0039712 H D mis40--------
rs803566671,2,4
Diabetes mellitus, permanent neonatal (PNDM)4--see VAR_0637302 mis40--------
rs803566681,2,4
Diabetes mellitus, permanent neonatal (PNDM)4--see VAR_0637312 mis40--------
rs1219082761,2,4
Diabetes mellitus, permanent neonatal (PNDM)4--see VAR_0637392 mis40--------

HapMap Linkage Disequilibrium report for INS (2181009 - 2182571 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10 variations for INS:    About this table    
Variant IDTypeSubtypePubMed ID
dgv994n71CNV Loss21882294
nsv896796CNV Loss21882294
nsv896776CNV Loss21882294
dgv995n71CNV Loss21882294
nsv896798CNV Loss21882294
nsv896797CNV Loss21882294
dgv992n71CNV Loss21882294
dgv997n71CNV Loss21882294
nsv896793CNV Gain21882294
nsv467645CNV Gain19166990

Human Gene Mutation Database (HGMD): INS
Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing INS
DNA2.0 Custom Variant and Variant Library Synthesis for INS

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
OMIM gene information: 176730   
OMIM disorders: 613370  606176  125852  
UniProtKB/Swiss-Prot: INS_HUMAN, P01308
  • Hyperproinsulinemia, familial (FHPRI) [MIM:176730]: An autosomal dominant condition characterized by
    elevated levels of serum proinsulin-like material. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Diabetes mellitus, insulin-dependent, 2 (IDDM2) [MIM:125852]: A multifactorial disorder of glucose
    homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical
    features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and
    secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and
    blood vessels. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Diabetes mellitus, permanent neonatal (PNDM) [MIM:606176]: A rare form of diabetes distinct from
    childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that
    is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy. Note=The
    disease is caused by mutations affecting the gene represented in this entry
  • Maturity-onset diabetes of the young 10 (MODY10) [MIM:613370]: A form of diabetes that is characterized
    by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of
    age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.
    Note=The disease is caused by mutations affecting the gene represented in this entry

  • Selected diseases for INS (see all 416):    
    About MalaCards
    insulin autoimmune syndrome    diabetes mellitus, insulin-dependent, 2    silent myocardial infarction    carbohydrate metabolic disorder
    hyperproinsulinemia, familial    neurogenic hypertension    maturity-onset diabetes of the young, type 10    ins-related permanent neonatal diabetes mellitus
    autoimmune polyendocrine syndrome type 2    hyperproinsulinemia, familial, with or without diabetes    fibrocalculous pancreatopathy    maturity-onset diabetes of the young type10
    brittle diabetes    diabetic ketoacidosis    ipex syndrome    autoimmune polyglandular syndrome type 2
    immunodysregulation, polyendocrinopathy and enteropathy x-linked    hypoglycemic coma    hair-an syndrome    rabson-mendenhall syndrome

    Selected diseases from the University of Copenhagen DISEASES database for INS (see all 59):
    Diabetes mellitus     Hypoglycemia     Hyperglycemia     Hyperinsulinism
    Hypertension     Polycystic ovary syndrome     Heart disease     Atherosclerosis
    Hyperandrogenism     Pancreatic cancer     Acanthosis nigricans     Diabetic retinopathy
    Adenoma     Hyperinsulinemic hypoglycemia     Kidney failure     Fatty liver disease
    Neuropathy     Autonomic neuropathy     Lipodystrophy     Hypoglycemic coma

    INS for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for INS gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    insulin resistance 99 64976 15209435 (13), 16489319 (13), 17588192 (12), 20419831 (12) (see all 99)
    insulin sensitivity 98 30603 20093961 (11), 8174845 (11), 9797852 (11), 11079822 (10) (see all 99)
    diabetes mellitus insulin-dependent 97.1 9678 2004172 (7), 9551692 (7), 1756017 (7), 7970366 (7) (see all 99)
    niddm 96.3 8629 10996359 (9), 9538982 (9), 9715376 (9), 10421979 (8) (see all 99)
    hyperinsulinemia 96.1 4397 16489319 (10), 7700881 (7), 8576790 (6), 2202884 (6) (see all 99)
    obesity 95.2 9985 14694215 (8), 18457598 (7), 9869004 (7), 16353333 (7) (see all 99)
    hypoglycemia 95.2 5243 10975210 (8), 9162611 (8), 18484562 (8), 11544612 (8) (see all 99)
    hyperglycemia 94.8 4252 1452531 (6), 2272633 (5), 18596634 (5), 19487929 (5) (see all 99)
    diabetes mellitus 93.7 3996 1357169 (6), 9509457 (5), 8913409 (5), 1966582 (4) (see all 99)
    impaired glucose tolerance 93.7 1378 8462385 (6), 8609839 (5), 2075783 (4), 1838062 (4) (see all 99)

    Genatlas disease: INS
    diabetes,with hyperproinsulinemia,putative susceptibility factor for obesity in association with IgF2 in British
    population

    GeneTests: INS
    GeneReviews: INS
    Genetic Association Database (GAD): INS
    Human Genome Epidemiology (HuGE) Navigator: INS (430 documents)

    Export disorders for INS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for INS gene, integrated from 10 sources (see all 15302):
    (articles sorted by number of sources associating them with INS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Insulin mutation screening in 1,044 patients with diabetes: mutations in the INS gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood. (PubMed id 18162506)1, 2, 4, 9 Edghill E.L.... Ellard S. (Diabetes 2008)
    2. Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR. (PubMed id 8358440)1, 2, 4 Lucassen A.M.... Bell J.I. (Nat. Genet. 1993)
    3. A mutation in the B chain coding region is associated with impaired proinsulin conversion in a family with hyperproinsulinemia. (PubMed id 3470784)1, 2, 4 Chan S.J.... Steiner D.F. (Proc. Natl. Acad. Sci. U.S.A. 1987)
    4. Sequence of the human insulin gene. (PubMed id 6243748)1, 2, 3 Bell G.I....Goodman H.M. (Nature 1980)
    5. Insulinomas and expression of an insulin splice variant. (PubMed id 15070567)1, 2, 9 Minn A.H.... Shalev A. (Lancet 2004)
    6. Genotypic and phenotypic differences between Arabian and Scandinavian women with gestational diabetes mellitus. (PubMed id 15095040)1, 4, 9 Shaat N....Groop L. (Diabetologia 2004)
    7. Insulin resistance-related genes and advanced left-sided colorectal adenoma. (PubMed id 17416760)1, 4, 9 Gunter M.J....Peters U. (amp 2007)
    8. Prostate cancer risk and IRS1, IRS2, IGF1, and INS polymorphisms: strong association of IRS1 G972R variant and cancer risk. (PubMed id 15678496)1, 4, 9 Neuhausen S.L....Brothman A.R. (Prostate 2005)
    9. No association of INS-VNTR genotype and IAA autoantibodies. (PubMed id 15699505)1, 4, 9 PAcrez de Nanclares G....Castano L. (Ann. N. Y. Acad. Sci. 2004)
    10. Polymorphisms in candidate genes for type 2 diabetes mellitus in a Mexican population with metabolic syndrome findings. (PubMed id 14693412)1, 4, 9 SA!nchez-Corona J....Hanson R.L. (Diabetes Res. Clin. Pract. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 3630 HGNC: 6081 AceView: INS Ensembl:ENSG00000254647 euGenes: HUgn3630
    ECgene: INS Kegg: 3630 H-InvDB: INS

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for INS Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=INS[genesymbol]
    Insulin at Eli Lillyhttp://www.lillyDiabetes.com/Products/PatientInfo.cfm
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/009
    Wikipedia http://en.wikipedia.org/wiki/Insulin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for INS gene:
    Search GeneIP for patents involving INS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     EMD Millipore Purified and/or Recombinant INS Protein
     EMD Millipore Mono- and Polyclonal Antibodies for the study of INS
     Browse Small Molecules at EMD Millipore
     EMD Millipore Kits and Assays for the Analysis of INS
     
     EMD Millipore genomic analysis products

      
     Antibodies for INS (Proinsulin)   Browse Cell Culture Products  
     ELISAs for INS (Proinsulin)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Luminex Assays for INS (Insulin)  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for INS (Proinsulin)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for INS   OriGene RNAi products in human, mouse, rat for INS  
     OriGene qPCR primer pairs and template standards for INS   OriGene Protein Over-expression Lysate for INS  
     OriGene MassSpec something-or-other for INS   OriGene clones in human, mouse for INS  
     OriGene qSTAR qPCR primer pairs in human, mouse for INS   OriGene Purified Protein for INS  
     OriGene ORF clones in mouse, rat for INS   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for INS   OriGene Custom Protein Services for INS  

     
     
     Block miRNA regulation of human, mouse, rat INS using miScript Target Protectors SeqTarget long-range PCR primers for resequencing INS
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat INS Predesigned siRNA for gene silencing in human, mouse, rat INS
     QuantiFast Probe-based Assays in human, mouse, rat INS QuantiTect SYBR Green Assays in human, mouse, rat INS
     PCR Arrays including human, mouse, rat INS Search Chromatin IP Primers for INS
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat INS  GeneGlobe Interaction Network for INS
     Regulatory tfbs in INS promoter
     GenScript Custom Purified and Recombinant Proteins Services for INS GenScript cDNA clones with any tag delivered in your preferred vector for INS
     GenScript Custom Assay Services for INS GenScript Custom overexpressing Cell Line Services for INS
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for INS  (insulin)

     Search Tocris compounds for INS
     Proteins for INS
     Browse Sino Biological Cell Lysates
     cDNA Clones for INS
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     INS antibodies
     INS proteins
     INS lysates
     Antibodies for INS
     See all of Abcam's Antibodies, Kits and Proteins for INS
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for INS
     Proteins for INS
     Antibodies for INS
     ELISAs for INS
     CLIAs for INS



     Browse ESI BIO Cell Lines and PureStem Progenitors for INS
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INS
     Browse SwitchGear 3'UTR luciferase reporter plasmids for INS
     SwitchGear Promoter luciferase reporter plasmids for INS
     ThermoFisher Antibody for INS
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INS
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for INS
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for INS
     LSBio Antibodies in human, mouse, rat for INS
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      INS gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4