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INPPL1 Gene

protein-coding   GIFtS: 72
GCID: GC11P071935

Inositol Polyphosphate Phosphatase-Like 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Inositol Polyphosphate Phosphatase-Like 11 2     Phosphatidylinositol 3,4,5-Trisphosphate 5-Phosphatase 22
51C Protein1 2     Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatase 22
Protein 51C2 3     SH2 Domain-Containing Inositol-5'-Phosphatase 22
INPPL-12 3     EC 3.1.3.863
SHIP-22 3     Inositol Polyphosphate Phosphatase-Like Protein 13
SHIP22 3     SH2 Domain-Containing Inositol Phosphatase 23
SH2 Domain-Containing Inositol 5'-Phosphatase 22 3     EC 3.1.38
OPSMD2 5     EC 3.1.3.n18

External Ids:    HGNC: 60801   Entrez Gene: 36362   Ensembl: ENSG000001654587   OMIM: 6008295   UniProtKB: O153573   

Export aliases for INPPL1 gene to outside databases

Previous GC identifers: GC11P074268 GC11P073475 GC11P072157 GC11P071662 GC11P071613 GC11P071580 GC11P068230


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for INPPL1 Gene:
The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation
of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor
turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a
valuable biomarker for breast cancer. (provided by RefSeq, Jan 2009)

GeneCards Summary for INPPL1 Gene:
INPPL1 (inositol polyphosphate phosphatase-like 1) is a protein-coding gene. Diseases associated with INPPL1 include opsismodysplasia, and oculocerebrorenal syndrome. GO annotations related to this gene include actin binding and SH2 domain binding. An important paralog of this gene is INPP5E.

UniProtKB/Swiss-Prot: SHIP2_HUMAN, O15357
Function: Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of
phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively
regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent
insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While
overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin
signaling or GLUT4 trafficking. Confers resistance to dietary obesity. May act by regulating AKT2, but not AKT1,
phosphorylation at the plasma membrane. Part of a signaling pathway that regulates actin cytoskeleton remodeling.
Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major
impact on ligand-induced EGFR internalization and degradation. Participates in regulation of cortical and
submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 thereby regulating membrane ruffling. Regulates cell adhesion
and cell spreading. Required for HGF-mediated lamellipodium formation, cell scattering and spreading. Acts as a
negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation. Acts as a
regulator of neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial protrusive
pattern, and later, maintain proper neurite outgrowth. Acts as a negative regulator of the FC-gamma-RIIA receptor
(FCGR2A). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating
signal transduction from activating immune/hematopoietic cell receptor systems. Involved in EGF signaling
pathway. Upon stimulation by EGF, it is recruited by EGFR and dephosphorylates PtdIns(3,4,5)P3. Plays a negative
role in regulating the PI3K-PKB pathway, possibly by inhibiting PKB activity. Down-regulates Fc-gamma-R-mediated
phagocytosis in macrophages independently of INPP5D/SHIP1. In macrophages, down-regulates NF-kappa-B-dependent
gene transcription by regulating macrophage colony-stimulating factor (M-CSF)-induced signaling. May also
hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6.
Involved in endochondral ossification

Gene Wiki entry for INPPL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the INPPL1 gene promoter:
         Max1   Egr-3   GATA-3   AP-1   ATF-2   CRE-BP1   POU2F1   POU2F1a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): INPPL1 promoter sequence
   Search Chromatin IP Primers for INPPL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat INPPL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.4   HGNC cytogenetic band: 11q23

INPPL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INPPL1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P071935:  view genomic region     (about GC identifiers)

Start:
71,934,745 bp from pter      End:
71,950,191 bp from pter
Size:
15,447 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SHIP2_HUMAN, O15357 (See protein sequence)
Recommended Name: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2  
Size: 1258 amino acids; 138599 Da
Subunit: Interacts with tyrosine phosphorylated form of SHC1, Interacts with EGFR. Upon stimulation by the EGF
signaling pathway, it forms a complex with SHC1 and EGFR. Interacts with cytoskeletal protein SORBS3/vinexin,
promoting its localization to the periphery of cells. Forms a complex with filamin (FLNA or FLNB), actin, GPIb
(GP1BA or GP1BB) that regulates cortical and submembraneous actin. Interacts with c-Met/MET, when c-Met/MET is
phosphorylated on 'Tyr-1356'. Interacts with p130Cas/BCAR1. Interacts with CENTD3/ARAP3 via its SAM domain.
Interacts with c-Cbl/CBL and CAP/SORBS1. Interacts with activated EPHA2 receptor. Interacts with receptors FCGR2A
and FCGR2B. Interacts with tyrosine kinases ABL1 and TEC. Interacts with CSF1R
Miscellaneous: Its ability to confer resistance to dietary obesity suggests that it may serve as a possible
therapeutic target in cases of type 2 diabetes and obesity
Sequence caution: Sequence=AAA50503.1; Type=Frameshift; Positions=1153; Sequence=AAA96658.1; Type=Frameshift;
Positions=Several;
4 PDB 3D structures from and Proteopedia for INPPL1:
2K4P (3D)        2KSO (3D)        3NR8 (3D)        4A9C (3D)    
Secondary accessions: B2RTX5 Q13577 Q13578
Alternative splicing: 2 isoforms:  O15357-1   O15357-2   

Explore the universe of human proteins at neXtProt for INPPL1: NX_O15357

Explore proteomics data for INPPL1 at MOPED

Post-translational modifications: 

  • Tyrosine phosphorylated by the members of the SRC family after exposure to a diverse array of extracellular
    stimuli such as insulin, growth factors such as EGF or PDGF, chemokines, integrin ligands and hypertonic and
    oxidative stress. May be phosphorylated upon IgG receptor FCGR2B-binding. Phosphorylated at Tyr-986 following
    cell attachment and spreading. Phosphorylated at Tyr-1162 following EGF signaling pathway stimulation.
    Phosphorylated at Thr-958 in response to PDGF1
  • Ubiquitination2 at Lys224, Lys234, Lys331
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for INPPL1 (O15357) (see all 29)
     QAYIEFE  LPPRSGS  RFTHLFW  VHTYRIL 


    See INPPL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001558.3  
    ENSEMBL proteins: 
     ENSP00000440904   ENSP00000440512   ENSP00000298229   ENSP00000444619   ENSP00000440018  
     ENSP00000444630   ENSP00000437852   ENSP00000441094   ENSP00000321775   ENSP00000446360  
    Reactome Protein details: O15357

    INPPL1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Enzo Life Sciences proteins for INPPL1
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for INPPL1
    GenScript Custom Purified and Recombinant Proteins Services for INPPL1
    Novus Biologicals INPPL1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for INPPL1

    INPPL1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of INPPL1
    R&D Systems Antibodies for INPPL1 (SHIP2)
    Cell Signaling Technology (CST) Antibodies for INPPL1  (SHIP-2)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for INPPL1
    Novus Biologicals INPPL1 Antibodies
    Abcam antibodies for INPPL1
    Cloud-Clone Corp. Antibodies for INPPL1
    ThermoFisher Antibody for INPPL1
    LSBio Antibodies in human, mouse, rat for INPPL1

    INPPL1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for INPPL1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for INPPL1
    Cloud-Clone Corp. CLIAs for INPPL1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SH2D: SH2 domain containing
    SAMD: Sterile alpha motif (SAM) domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: INPPL1
    Inositol polyphosphate phosphatases

    Selected InterPro protein domains (see all 6):
     IPR021129 SAM_type1
     IPR000300 IPPc
     IPR013761 SAM/pointed
     IPR001660 SAM
     IPR005135 Endo/exonuclease/phosphatase

    Graphical View of Domain Structure for InterPro Entry O15357

    ProtoNet protein and cluster: O15357

    3 Blocks protein domains:
    IPB000300 Inositol polyphosphate related phosphatase family
    IPB000980 SH2 domain signature
    IPB001660 Sterile alpha motif SAM


    UniProtKB/Swiss-Prot: SHIP2_HUMAN, O15357
    Domain: The SH2 domain interacts with tyrosine phosphorylated forms of proteins such as SHC1 or FCGR2A. It also
    mediates the interaction with p130Cas/BCAR1
    Domain: The NPXY sequence motif found in many tyrosine-phosphorylated proteins is required for the specific
    binding of the PID domain (By similarity)
    Similarity: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family
    Similarity: Contains 1 SAM (sterile alpha motif) domain
    Similarity: Contains 1 SH2 domain


    INPPL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SHIP2_HUMAN, O15357
    Function: Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of
    phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively
    regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent
    insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While
    overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin
    signaling or GLUT4 trafficking. Confers resistance to dietary obesity. May act by regulating AKT2, but not AKT1,
    phosphorylation at the plasma membrane. Part of a signaling pathway that regulates actin cytoskeleton remodeling.
    Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major
    impact on ligand-induced EGFR internalization and degradation. Participates in regulation of cortical and
    submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 thereby regulating membrane ruffling. Regulates cell adhesion
    and cell spreading. Required for HGF-mediated lamellipodium formation, cell scattering and spreading. Acts as a
    negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation. Acts as a
    regulator of neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial protrusive
    pattern, and later, maintain proper neurite outgrowth. Acts as a negative regulator of the FC-gamma-RIIA receptor
    (FCGR2A). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating
    signal transduction from activating immune/hematopoietic cell receptor systems. Involved in EGF signaling
    pathway. Upon stimulation by EGF, it is recruited by EGFR and dephosphorylates PtdIns(3,4,5)P3. Plays a negative
    role in regulating the PI3K-PKB pathway, possibly by inhibiting PKB activity. Down-regulates Fc-gamma-R-mediated
    phagocytosis in macrophages independently of INPP5D/SHIP1. In macrophages, down-regulates NF-kappa-B-dependent
    gene transcription by regulating macrophage colony-stimulating factor (M-CSF)-induced signaling. May also
    hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6.
    Involved in endochondral ossification
    Catalytic activity: 1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol
    3,4-diphosphate + phosphate
    Enzyme regulation: Activated upon translocation to the sites of synthesis of PtdIns(3,4,5)P3 in the membrane.
    Enzymatic activity is enhanced in the presence of phosphatidylserine
    Induction: By bacterial lipopolysaccharides (LPS)

         Genatlas biochemistry entry for INPPL1:
    inositol polyphosphate phosphatase-like 1

         Enzyme Numbers (IUBMB): EC 3.1.32 EC 3.1.3.n12 EC 3.1.3.861

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0004445inositol-polyphosphate 5-phosphatase activity ----
    GO:0005515protein binding IPI11158326
    GO:0005547phosphatidylinositol-3,4,5-trisphosphate binding ----
    GO:0016787hydrolase activity IEA--
         
    INPPL1 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Inppl1):
     behavior/neurological  craniofacial  growth/size/body  homeostasis/metabolism  mortality/aging 
     respiratory system 

    INPPL1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Phox2a/Inppl1Phox2a/tm1Ssch for INPPL1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for INPPL1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for INPPL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for INPPL1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for INPPL1

    miRNA
    Products:
        
    miRTarBase miRNAs that target INPPL1:
    hsa-mir-335-5p (MIRT018943), hsa-mir-326 (MIRT043623), hsa-let-7b-5p (MIRT032460), hsa-mir-184 (MIRT004354), hsa-mir-205-5p (MIRT003238), hsa-mir-671-5p (MIRT039295), hsa-mir-27b-3p (MIRT046205)

    Block miRNA regulation of human, mouse, rat INPPL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate INPPL1 (see all 19):
    hsa-miR-579 hsa-miR-34b* hsa-miR-185* hsa-miR-1180 hsa-miR-548a-3p hsa-miR-3687 hsa-miR-641 hsa-miR-548x
    SwitchGear 3'UTR luciferase reporter plasmidINPPL1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for INPPL1
    Predesigned siRNA for gene silencing in human, mouse, rat INPPL1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for INPPL1

    Clone
    Products:
         
    OriGene clones in human, mouse for INPPL1 (see all 8)
    OriGene ORF clones in mouse, rat for INPPL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: INPPL1 (NM_001567)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INPPL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INPPL1

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INPPL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SHIP2_HUMAN, O15357: Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Cell
    projection, filopodium. Cell projection, lamellipodium. Note=Translocates to membrane ruffles when activated,
    translocation is probably due to different mechanisms depending on the stimulus and cell type. Partly
    translocated via its SH2 domain which mediates interaction with tyrosine phosphorylated receptors such as the
    FC-gamma-RIIB receptor (FCGR2B). Tyrosine phosphorylation may also participate in membrane localization. Insulin
    specifically stimulates its redistribution from the cytosol to the plasma membrane. Recruited to the membrane
    following M-CSF stimulation. In activated spreading platelets, localizes with actin at filopodia, lamellipodia
    and the central actin ring
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol5
    golgi apparatus4
    nucleus2
    plasma membrane2

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton IEA--
    GO:0005886plasma membrane IEA--

    INPPL1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for INPPL1 About   (see all 20)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Inositol phosphate metabolism (KEGG)
    Inositol phosphate metabolism0.61
    D-myo-inositol (1,3,4)-trisphosphate biosynthesis0.00
    Phosphatidylinositol signaling system0.61
    D-myo-inositol (1,4,5)-trisphosphate degradation0.00
    superpathway of inositol phosphate compounds0.60
    1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)0.00
    superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism0.00
    2Signaling by Interleukins
    Interleukin receptor SHC signaling0.67
    Interleukin-3, 5 and GM-CSF signaling0.59
    Interleukin-2 signaling0.67
    Signaling by Interleukins0.42
    3PI Metabolism
    PI Metabolism0.65
    Synthesis of PIPs at the plasma membrane0.65
    4Inositol phosphate metabolism (REACTOME)
    Inositol phosphate metabolism0.59
    Synthesis of IP3 and IP4 in the cytosol0.59
    5Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Cell Signaling Technology (CST) Pathways for INPPL1
        Phosphatases
    Lymphocyte Signaling
    PI3K / Akt Signaling

    Selected BioSystems Pathways for INPPL1 (see all 12)
        EGFR1 Signaling Pathway
    Insulin Signaling
    IL-6 Signaling Pathway
    1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)
    D-myo-inositol (1,3,4)-trisphosphate biosynthesis

    3 Reactome Pathways for INPPL1
        Interleukin receptor SHC signaling
    Synthesis of PIPs at the plasma membrane
    Synthesis of IP3 and IP4 in the cytosol


    5 Kegg Pathways  (Kegg details for INPPL1):
        Inositol phosphate metabolism
    Phosphatidylinositol signaling system
    B cell receptor signaling pathway
    Fc gamma R-mediated phagocytosis
    Insulin signaling pathway


    INPPL1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including INPPL1: 
              Diabetes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for INPPL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for INPPL1 (O153571, 2, 3 ENSP000002982294) via UniProtKB, MINT, STRING, and/or I2D (see all 89)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITSN1Q158112, ENSP000003707194MINT-6673475 MINT-6673513 MINT-6673386 MINT-6673604 MINT-6673447 MINT-6673542 MINT-6673557 MINT-6673462 MINT-6673572 MINT-6673429 STRING: ENSP00000370719
    SORBS3O605042, 3, ENSP000002401234MINT-8078944 MINT-8078922 MINT-8078984 I2D: score=3 STRING: ENSP00000240123
    BCAR1P569451, 3, ENSP000001623304EBI-1384248,EBI-702093 I2D: score=2 STRING: ENSP00000162330
    ABI1Q8IZP02, 3, ENSP000003653124MINT-7908602 I2D: score=1 STRING: ENSP00000365312
    SORBS1Q9BX661, 3, ENSP000003602724EBI-1384248,EBI-433642 I2D: score=3 STRING: ENSP00000360272 STRING: ENSP00000355136
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001958endochondral ossification IMP--
    GO:0002376immune system process IEA--
    GO:0006006glucose metabolic process IEA--
    GO:0006644phospholipid metabolic process TAS--
    GO:0006661phosphatidylinositol biosynthetic process TAS--

    INPPL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for INPPL1 (SHIP2)

    Selected HMDB Compounds for INPPL1 (see all 509)    About this table
    CompoundSynonyms CAS #PubMed Ids
    1D-Myo-inositol 1,4-bisphosphate1D-Myo-inositol 1,4-bisphosphate (see all 5)47055-78-7--
    Inositol 1,3,4,5-tetraphosphate1,3,4,5-tetrakis(dihydrogen phosphate) myo-Inositol (see all 16)102850-29-3--
    Inositol 1,3,4-trisphosphate1,3,4-Itp (see all 8)98102-63-7--
    Inositol 1,4,5-trisphosphate1D-myo-Inositol 1,4,5-trisphosphate (see all 4)88269-39-0--
    PI(16:0/16:0)Phosphatidylinositol(32:0) (see all 8)----
    PI(16:0/16:1(9Z))Phosphatidylinositol(32:1) (see all 14)----
    PI(16:0/16:2(9Z,12Z))Phosphatidylinositol(16:0/16:2n4) (see all 18)----
    PI(16:0/18:0)Phosphatidylinositol(16:0/18:0) (see all 8)----
    PI(16:0/18:1(11Z))Phosphatidylinositol(16:0/18:1w7) (see all 14)----
    PI(16:0/18:1(9Z))Phosphatidylinositol(16:0/18:1) (see all 14)----

    10 Novoseek inferred chemical compound relationships for INPPL1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inositol 85.4 31 10381377 (2), 15220217 (2), 16842857 (1), 16824732 (1) (see all 22)
    phosphatidylinositol-3,4,5-trisphosphate 83.8 11 12885297 (4), 15668240 (1), 17135240 (1), 15964236 (1) (see all 6)
    phosphatidylinositol 69.7 18 17135240 (3), 15668240 (1), 12351701 (1), 12676785 (1) (see all 11)
    phosphoinositide 67.7 6 17135240 (1), 12769675 (1), 15168016 (1), 15964236 (1) (see all 6)
    inositol 1,3,4,5-tetrakisphosphate 58.4 2 16824732 (1), 10610720 (1)
    tyrosine 55.2 46 10194451 (4), 10381377 (3), 12235291 (3), 18486448 (3) (see all 17)
    phosphotyrosine 46.1 4 10381377 (2), 17938406 (1)
    lipid 31.2 10 16842857 (1), 16824732 (1), 17672824 (1), 19001549 (1) (see all 10)
    thymidine 10.1 3 10381377 (1), 11359765 (1), 14502564 (1)
    glucose 3.48 4 17671700 (2), 16842857 (1)



    INPPL1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for INPPL1 gene: 
    NM_001567.3  

    Unigene Cluster for INPPL1:

    Inositol polyphosphate phosphatase-like 1
    Hs.523875  [show with all ESTs]
    Unigene Representative Sequence: Y14385
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000540973 ENST00000543234 ENST00000298229 ENST00000541544 ENST00000538751(uc001osg.3)
    ENST00000540329 ENST00000537656 ENST00000538339 ENST00000537755 ENST00000544806
    ENST00000541303 ENST00000542295 ENST00000545355 ENST00000535985 ENST00000541752
    ENST00000320683 ENST00000541756(uc001osf.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat INPPL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate INPPL1 (see all 19):
    hsa-miR-579 hsa-miR-34b* hsa-miR-185* hsa-miR-1180 hsa-miR-548a-3p hsa-miR-3687 hsa-miR-641 hsa-miR-548x
    SwitchGear 3'UTR luciferase reporter plasmidINPPL1 3' UTR sequence
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    Predesigned siRNA for gene silencing in human, mouse, rat INPPL1
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    GenScript: all cDNA clones in your preferred vector: INPPL1 (NM_001567)
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      QuantiFast Probe-based Assays in human, mouse, rat INPPL1

    Additional mRNA sequence: 

    BC140853.1 L24444.1 L36818.1 Y14385.1 

    20 DOTS entries:

    DT.446512  DT.91760060  DT.100792230  DT.97785656  DT.95190629  DT.120744872  DT.120744917  DT.100030826 
    DT.100792234  DT.317042  DT.85100069  DT.95352215  DT.95370691  DT.120744923  DT.85100070  DT.95245728 
    DT.100045872  DT.70105392  DT.91760053  DT.95188303 

    Selected AceView cDNA sequences (see all 475):

    BF111505 AI356171 AW044313 AI077424 AW044430 CA444995 BM711421 AI475434 
    BM719193 BU159622 BM988739 BQ953040 AI370821 AA988088 CD612022 AI612753 
    BQ932403 BM769439 BI523616 CA389602 BE504271 CO400828 AU134190 AI393907 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for INPPL1 (see all 21)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c ^ 15a · 15b ^ 16a · 16b ·
    SP1:                                                                                                                                            -     -         
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                    -                       -     -         
    SP5:                                                                                                                                            -     -         

    ExUns: 16c ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24a · 24b · 24c ^ 25 ^ 26a · 26b ^ 27a · 27b · 27c · 27d · 27e ^ 28a · 28b ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 29a · 29b · 29c
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for INPPL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    INPPL1 expression in normal human tissues (normalized intensities)      INPPL1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTACCGAGG
    INPPL1 Expression
    About this image


    INPPL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Bone (Muscoskeletal System)
             Membranous Facial Bones
     
     Thyroid (Endocrine System)
    INPPL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    INPPL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.523875

    UniProtKB/Swiss-Prot: SHIP2_HUMAN, O15357
    Tissue specificity: Widely expressed, most prominently in skeletal muscle, heart and brain. Present in platelets.
    Expressed in transformed myeloid cells and in primary macrophages, but not in peripheral blood monocytes

        Pathway & Disease-focused RT2 Profiler PCR Array including INPPL1: 
              Diabetes in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INPPL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for INPPL1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Inppl11 , 5 inositol polyphosphate phosphatase-like 11, 5 88.99(n)1
    96.02(a)1
      7 (54.67 cM)5
    163321  NM_001122739.11  NP_001116211.11 
     1018226335 
    chicken
    (Gallus gallus)
    Aves INPPL16
    inositol polyphosphate phosphatase-like 1
    58(a)
    1 ↔ 1
    4(1207065-1216117) ENSGALG00000004336
    lizard
    (Anolis carolinensis)
    Reptilia INPPL16
    inositol polyphosphate phosphatase-like 1
    76(a)
    1 ↔ 1
    GL344030.1(9126-86018)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.177262 Transcribed sequence with moderate similarity to protein more 77.51(n)    AL956024.2 
    zebrafish
    (Danio rerio)
    Actinopterygii inppl1a1 inositol polyphosphate phosphatase-like 1a 71.51(n)
    76.74(a)
      325179  NM_001039804.2  NP_001034893.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ocrl6
    Oculocerebrorenal syndrome of Lowe 1 ortholog
    16(a)
    1 → many
    X(1817014-1821557)
    worm
    (Caenorhabditis elegans)
    Secernentea ocrl-16
    Protein OCRL-1, isoform a
    19(a)
    1 → many
    I(9715322-9728108) WBGene00007620


    ENSEMBL Gene Tree for INPPL1 (if available)
    TreeFam Gene Tree for INPPL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for INPPL1 gene
    INPP5E2  INPP5B2  INPP5J2  SYNJ12  OCRL2  INPP5D2  INPP5K2  SYNJ22  
    3 SIMAP similar genes for INPPL1 using alignment to 8 protein entries:     SHIP2_HUMAN (see all proteins):
    SH2D1B    SH2D1A    INPP5D

    INPPL1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for INPPL1 (see all 488)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0695874
    Opsismodysplasia (OPSMD)4--see VAR_0695872 P S mis40--------
    VAR_0695894
    Opsismodysplasia (OPSMD)4--see VAR_0695892 F I mis40--------
    VAR_0695884
    Opsismodysplasia (OPSMD)4--see VAR_0695882 W C mis40--------
    VAR_0695864
    Opsismodysplasia (OPSMD)4--see VAR_0695862 R W mis40--------
    rs1146653981,2
    F--71797533(+) GGATTC/ACCCTC 1 -- us2k11Minor allele frequency- A:0.07WA 118
    rs773480831,2
    C--71797584(+) GAGAAC/AGGTGG 1 -- us2k13Minor allele frequency- A:0.12CSA WA NA 240
    rs1428163191,2
    --71797656(+) TTAGTA/TATTAT 1 -- us2k10--------
    rs781767491,2
    --71798040(+) CCCTCG/TGCTGG 1 -- us2k10--------
    rs746357291,2
    C,F--71798045(+) GGCTGG/AAGGGG 1 -- us2k12Minor allele frequency- A:0.11WA EA 238
    rs1480670521,2
    --71798284(+) CCAGGC/TCCGGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for INPPL1 (71934745 - 71950191 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for INPPL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1221n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): INPPL1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing INPPL1
    DNA2.0 Custom Variant and Variant Library Synthesis for INPPL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600829   
    OMIM disorders: 258480  
    UniProtKB/Swiss-Prot: SHIP2_HUMAN, O15357
  • Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose
    homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese
    body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance,
    hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes,
    kidneys, nerves, and blood vessels. Note=Disease susceptibility may be associated with variations affecting the
    gene represented in this entry
  • Note=Genetic variations in INPPL1 may be a cause of susceptibility to metabolic syndrome. Metabolic
    syndrome is characterized by diabetes, insulin resistance, hypertension, and hypertriglyceridemia is absent
  • Opsismodysplasia (OPSMD) [MIM:258480]: A rare skeletal dysplasia involving delayed bone maturation.
    Clinical signs observed at birth include short limbs, small hands and feet, relative macrocephaly with a large
    anterior fontanel, and characteristic craniofacial abnormalities including a prominent brow, depressed nasal
    bridge, a small anteverted nose, and a relatively long philtrum. Death secondary to respiratory failure during
    the first few years of life has been reported, but there can be long-term survival. Typical radiographic findings
    include shortened long bones with very delayed epiphyseal ossification, severe platyspondyly, metaphyseal
    cupping, and characteristic abnormalities of the metacarpals and phalanges. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • Selected diseases for INPPL1 (see all 26):    About MalaCards
    opsismodysplasia    oculocerebrorenal syndrome    cellulitis    glucose intolerance
    urticaria    breast cancer    hypertriglyceridemia    insulin resistance
    hyperglycemia    essential hypertension    laryngeal squamous cell carcinoma    obesity
    hypertension    laryngitis    diabetes mellitus    esophagitis
    psoriasis    myeloma    hepatocellular carcinoma    adenocarcinoma

    1 disease from the University of Copenhagen DISEASES database for INPPL1:
    Oculocerebrorenal syndrome

    INPPL1 for disorders           About GeneDecksing

    6 Novoseek inferred disease relationships for INPPL1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    insulin resistance 49.7 15 15654601 (4), 16842857 (2), 14683460 (2), 19272022 (1) (see all 7)
    insulin sensitivity 34.9 7 14683460 (2), 16842857 (1), 15220217 (1)
    obesity 30.6 10 16842857 (2), 17557929 (1), 15964236 (1), 16973905 (1) (see all 5)
    niddm 11.8 2 14683460 (1), 15964236 (1)
    breast cancer 0 10 19082482 (4), 19065064 (3)
    tumors 0 3 14662322 (1), 19082482 (1), 12692707 (1)

    Genetic Association Database (GAD): INPPL1
    Human Genome Epidemiology (HuGE) Navigator: INPPL1 (5 documents)

    Export disorders for INPPL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for INPPL1 gene, integrated from 10 sources (see all 140):
    (articles sorted by number of sources associating them with INPPL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic association analysis of inositol polyphosphate phosphatase- like 1 (INPPL1, SHIP2) variants with essential hypertension. (PubMed id 17557929)1, 2, 4, 9 Braga Marcano A.C.... Munroe P.B. (J. Med. Genet. 2007)
    2. Cloning and characterization of a human cDNA (INPPL1) sharing homology with inositol polyphosphate phosphatases. (PubMed id 8530088)1, 2, 3, 9 Hejna J.A.... Moses R.E. (Genomics 1995)
    3. SHIP-2 inositol phosphatase is inducibly expressed in human monocytes and serves to regulate Fcgamma receptor-mediated signaling. (PubMed id 12690104)1, 2, 9 Pengal R.A....Tridandapani S. (J. Biol. Chem. 2003)
    4. Src family tyrosine kinases regulate adhesion-dependent tyrosine phosphorylation of 5'-inositol phosphatase SHIP2 during cell attachment and spreading on collagen I. (PubMed id 12235291)1, 2, 9 Prasad N.... Decker S.J. (J. Cell Sci. 2002)
    5. A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5- phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells. (PubMed id 10194451)1, 2, 9 Wisniewski D.... Clarkson B. (Blood 1999)
    6. SH2-containing 5'-inositol phosphatase, SHIP2, regulates cytoskeleton organization and ligand-dependent down-regulation of the epidermal growth factor receptor. (PubMed id 15668240)1, 2, 9 Prasad N.K. and Decker S.J. (J. Biol. Chem. 2005)
    7. SH2-containing inositol 5'-phosphatase SHIP2 associates with the p130(Cas) adapter protein and regulates cellular adhesion and spreading. (PubMed id 11158326)1, 2, 9 Prasad N.... Decker S.J. (Mol. Cell. Biol. 2001)
    8. Polymorphisms in type II SH2 domain-containing inositol 5-phosphatase (INPPL1, SHIP2) are associated with physiological abnormalities of the metabolic syndrome. (PubMed id 15220217)1, 2, 9 Kaisaki P.J....Gauguier D. (Diabetes 2004)
    9. Regulation of PDGF-stimulated SHIP2 tyrosine phosphorylation and association with Shc in 3T3-L1 preadipocytes. (PubMed id 17219406)1, 2, 9 Artemenko Y.... Sorisky A. (J. Cell. Physiol. 2007)
    10. The Src homology 2 domain containing inositol 5-phosphatase SHIP2 is recruited to the epidermal growth factor (EGF) receptor and dephosphorylates phosphatidylinositol 3,4,5-trisphosphate in EGF- stimulated COS-7 cells. (PubMed id 11349134)1, 2, 9 Pesesse X.... Erneux C. (J. Biol. Chem. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3636 HGNC: 6080 AceView: INPPL1 Ensembl:ENSG00000165458 euGenes: HUgn3636
    ECgene: INPPL1 Kegg: 3636 H-InvDB: INPPL1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for INPPL1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for INPPL1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for INPPL1 gene:
    Search GeneIP for patents involving INPPL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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