INPPL1 Gene
protein-coding GIFtS: 67
GCID: GC11P071935
|
|
inositol polyphosphate phosphatase-like 1
| |
Aliases
for INPPL1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Inositol Polyphosphate Phosphatase-Like 11 2 | | Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatase 22 | | SHIP21 2 3 | | SH2 Domain-Containing Inositol-5'-Phosphatase 22 | | Protein 51C2 3 | | EC 3.1.3.863 | | INPPL-12 3 | | Inositol Polyphosphate Phosphatase-Like Protein 13 | | SHIP-22 3 | | SH2 Domain-Containing Inositol Phosphatase 23 | | SH2 Domain-Containing Inositol 5'-Phosphatase 22 3 | | EC 3.1.38 | | 51C Protein2 | | EC 3.1.3.N11 | | Phosphatidylinositol 3,4,5-Trisphosphate 5-Phosphatase 22 | | |
Export aliases for INPPL1 gene to outside databasesPrevious GC identifers: GC11P074268 GC11P073475 GC11P072157 GC11P071662 GC11P071613 GC11P071580 GC11P068230 |
Summaries
for INPPL1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for INPPL1:
The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation ofinsulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnoverand actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarkerfor breast cancer. (provided by RefSeq, Jan 2009)
UniProtKB/Swiss-Prot: SHIP2_HUMAN, O15357Function: Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate ofphosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating thePI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling,although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces bothinsulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking.Confers resistance to dietary obesity. May act by regulating AKT2, but not AKT1, phosphorylation at the plasmamembrane. Part of a signaling pathway that regulates actin cytoskeleton remodeling. Required for the maintenance anddynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFRinternalization and degradation. Participates in regulation of cortical and submembraneous actin by hydrolyzingPtdIns(3,4,5)P3 thereby regulating membrane ruffling. Regulates cell adhesion and cell spreading. Required forHGF-mediated lamellipodium formation, cell scattering and spreading. Acts as a negative regulator of EPHA2 receptorendocytosis by inhibiting via PI3K-dependent Rac1 activation. Acts as a regulator of neuritogenesis by regulatingPtdIns(3,4,5)P3 level and is required to form an initial protrusive pattern, and later, maintain proper neuriteoutgrowth. Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A). Mediates signaling from theFC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activatingimmune/hematopoietic cell receptor systems. Involved in EGF signaling pathway. Upon stimulation by EGF, it isrecruited by EGFR and dephosphorylates PtdIns(3,4,5)P3. Plays a negative role in regulating the PI3K-PKB pathway,possibly by inhibiting PKB activity. Down-regulates Fc-gamma-R-mediated phagocytosis in macrophages independently ofINPP5D/SHIP1. In macrophages, down-regulates NF-kappa-B-dependent gene transcription by regulating macrophagecolony-stimulating factor (M-CSF)-induced signaling. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect thelevels of the higher inositol polyphosphates like InsP6
Gene Wiki entry for INPPL1
|
Genomic Views
for INPPL1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the INPPL1 gene promoter:
Max1 Egr-3 GATA-3 AP-1 ATF-2 CRE-BP1 POU2F1 POU2F1a c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for INPPL1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INPPL1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q13.4 HGNC cytogenetic band: 11q23INPPL1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P071935: view genomic region
(about GC identifiers)
Start:
|
71,934,745 bp from pter |
End:
|
71,950,191 bp from pter |
Size:
|
15,447 bases |
Orientation:
|
plus strand |
|
Proteins
for INPPL1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SHIP2_HUMAN, O15357 (See
protein sequence)Recommended Name: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 Size: 1258 amino acids; 138599 Da
Subunit: Interacts with tyrosine phosphorylated form of SHC1, Interacts with EGFR. Upon stimulation by the EGFsignaling pathway, it forms a complex with SHC1 and EGFR. Interacts with cytoskeletal protein SORBS3/vinexin,promoting its localization to the periphery of cells. Forms a complex with filamin (FLNA or FLNB), actin, GPIb (GP1BAor GP1BB) that regulates cortical and submembraneous actin. Interacts with c-Met/MET, when c-Met/MET is phosphorylatedon 'Tyr-1356'. Interacts with p130Cas/BCAR1. Interacts with CENTD3/ARAP3 via its SAM domain. Interacts with c-Cbl/CBLand CAP/SORBS1. Interacts with activated EPHA2 receptor. Interacts with receptors FCGR2A and FCGR2B. Interacts withtyrosine kinases ABL1 and TEC. Interacts with CSF1R
Subcellular location: Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Cellprojection, filopodium. Cell projection, lamellipodium. Note=Translocates to membrane ruffles when activated,translocation is probably due to different mechanisms depending on the stimulus and cell type. Partly translocated viaits SH2 domain which mediates interaction with tyrosine phosphorylated receptors such as the FC-gamma-RIIB receptor(FCGR2B). Tyrosine phosphorylation may also participate in membrane localization. Insulin specifically stimulates itsredistribution from the cytosol to the plasma membrane. Recruited to the membrane following M-CSF stimulation. Inactivated spreading platelets, localizes with actin at filopodia, lamellipodia and the central actin ring
Miscellaneous: Its ability to confer resistance to dietary obesity suggests that it may serve as a possible therapeutictarget in cases of type 2 diabetes and obesity
Sequence caution: Sequence=AAA50503.1; Type=Frameshift; Positions=1153; Sequence=AAA96658.1; Type=Frameshift;Positions=Several;
4 PDB 3D structures from  and Proteopedia  for INPPL1:2K4P (3D)
2KSO (3D)
3NR8 (3D)
4A9C (3D)
Secondary accessions: B2RTX5 Q13577 Q13578Alternative splicing: 2 isoforms: O15357-1 O15357-2 Explore the universe of human proteins at neXtProt for INPPL1: NX_O15357
Post-translational modifications:
Tyrosine phosphorylated by the members of the SRC family after exposure to a diverse array of extracellular stimulisuch as insulin, growth factors such as EGF or PDGF, chemokines, integrin ligands and hypertonic and oxidative stress.May be phosphorylated upon IgG receptor FCGR2B-binding. Phosphorylated at Tyr-986 following cell attachment andspreading. Phosphorylated at Tyr-1162 following EGF signaling pathway stimulation. Phosphorylated at Thr-958 inresponse to PDGF1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O15357
4/29 DME Specific Peptides for INPPL1 (O15357) (see all 29)
INPPL1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001558.3
ENSEMBL proteins: ENSP00000440904 ENSP00000439160 ENSP00000440512 ENSP00000298229 ENSP00000444619 ENSP00000440018 ENSP00000444630 ENSP00000437852 ENSP00000441094 ENSP00000321775 ENSP00000446360 Reactome Protein details: O15357
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
INPPL1 for ontologies About GeneDecksing
INPPL1 Antibody Products:
Assay Products for INPPL1: |
Protein
Domains /
Families
for INPPL1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
INPPL1 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry O15357ProtoNet protein and cluster: O15357 3 Blocks protein families: IPB000300 Inositol polyphosphate related phosphatase family IPB000980 SH2 domain signature IPB001660 Sterile alpha motif SAM
UniProtKB/Swiss-Prot: SHIP2_HUMAN, O15357Domain: The SH2 domain interacts with tyrosine phosphorylated forms of proteins such as SHC1 or FCGR2A. It alsomediates the interaction with p130Cas/BCAR1Domain: The NPXY sequence motif found in many tyrosine-phosphorylated proteins is required for the specific binding ofthe PID domain (By similarity)Similarity: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase familySimilarity: Contains 1 SAM (sterile alpha motif) domainSimilarity: Contains 1 SH2 domain |
Function
for INPPL1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SHIP2_HUMAN, O15357Function: Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate ofphosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating thePI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling,although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces bothinsulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking.Confers resistance to dietary obesity. May act by regulating AKT2, but not AKT1, phosphorylation at the plasmamembrane. Part of a signaling pathway that regulates actin cytoskeleton remodeling. Required for the maintenance anddynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFRinternalization and degradation. Participates in regulation of cortical and submembraneous actin by hydrolyzingPtdIns(3,4,5)P3 thereby regulating membrane ruffling. Regulates cell adhesion and cell spreading. Required forHGF-mediated lamellipodium formation, cell scattering and spreading. Acts as a negative regulator of EPHA2 receptorendocytosis by inhibiting via PI3K-dependent Rac1 activation. Acts as a regulator of neuritogenesis by regulatingPtdIns(3,4,5)P3 level and is required to form an initial protrusive pattern, and later, maintain proper neuriteoutgrowth. Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A). Mediates signaling from theFC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activatingimmune/hematopoietic cell receptor systems. Involved in EGF signaling pathway. Upon stimulation by EGF, it isrecruited by EGFR and dephosphorylates PtdIns(3,4,5)P3. Plays a negative role in regulating the PI3K-PKB pathway,possibly by inhibiting PKB activity. Down-regulates Fc-gamma-R-mediated phagocytosis in macrophages independently ofINPP5D/SHIP1. In macrophages, down-regulates NF-kappa-B-dependent gene transcription by regulating macrophagecolony-stimulating factor (M-CSF)-induced signaling. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect thelevels of the higher inositol polyphosphates like InsP6Catalytic activity: 1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol3,4-diphosphate + phosphateEnzyme regulation: Activated upon translocation to the sites of synthesis of PtdIns(3,4,5)P3 in the membrane. Enzymaticactivity is enhanced in the presence of phosphatidylserineInduction: By bacterial lipopolysaccharides (LPS) Genatlas biochemistry entry for INPPL1:inositol polyphosphate phosphatase-like 1
Enzyme Numbers (IUBMB): EC 3.1.32 EC 3.1.3.n12 EC 3.1.3.861
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for INPPL1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for INPPL1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: INPPL1 (NM_001567) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for INPPL1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INPPL1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INPPL1 |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003779 | actin binding |
IEA | -- | | GO:0004445 | inositol-polyphosphate 5-phosphatase activity |
IEA | -- | | GO:0005515 | protein binding |
IPI | -- | | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding |
IEA | -- | | GO:0016787 | hydrolase activity |
-- | -- |
INPPL1 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Phox2a/Inppl1Phox2a/tm1Ssch for INPPL1
6 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Inppl1):
INPPL1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for INPPL1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/18 super-pathways (see all 18) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | D-myo-inositol (1,3,4)-trisphosphate biosynthesis | | | 2 | Interleukin receptor SHC signaling | | | 3 | Metabolism | | | 4 | Inositol phosphate metabolism | | | 5 | Synthesis of IP3 and IP4 in the cytosol | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 
Cell Signaling Technology (CST) Pathways for INPPL1
5/12  BioSystems Pathways for INPPL1 (see all 12)
5/13 
Reactome Pathways for INPPL1 (see all 13)
3 
Kegg Pathways (Kegg details for INPPL1):
INPPL1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for INPPL1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/67 Interacting proteins for INPPL1 (O153571, 2, 3 ENSP000002982294) via UniProtKB, MINT, STRING, and/or I2D (see all 67)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| ITSN1 | Q158112, ENSP000003707194 | MINT-6673475 MINT-6673513 MINT-6673386 MINT-6673604 MINT-6673447 MINT-6673542 MINT-6673557 MINT-6673462 MINT-6673572 MINT-6673429 STRING: ENSP00000370719 | | SORBS3 | O605042, 3, ENSP000002401234 | MINT-8078944 MINT-8078922 MINT-8078984 I2D:
score=3 STRING: ENSP00000240123 | | BCAR1 | P569451, 3, ENSP000001623304 | EBI-1384248,EBI-702093 I2D:
score=2 STRING: ENSP00000162330 | | ABI1 | Q8IZP02, 3, ENSP000003653124 | MINT-7908602 I2D:
score=1 STRING: ENSP00000365312 | | SORBS1 | Q9BX661, 3, ENSP000003551364 | EBI-1384248,EBI-433642 I2D:
score=3 STRING: ENSP00000355136 |
About this table
Gene Ontology (GO): 5/23 biological process terms (GO ID links to tree view) (see all 23): About this table
INPPL1 for ontologies About GeneDecksing
|
Drugs & Compounds
for INPPL1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
INPPL1 for compounds About GeneDecksing
 Browse Tocris compounds for INPPL1
10/509 HMDB Compounds for INPPL1 (see all 509) About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| 1D-Myo-inositol 1,4-bisphosphate | 1D-Myo-inositol 1,4-bisphosphate (see all 5) | 47055-78-7 | -- | | Inositol 1,3,4,5-tetraphosphate | 1,3,4,5-tetrakis(dihydrogen phosphate) myo-Inositol (see all 16) | 102850-29-3 | -- | | Inositol 1,3,4-trisphosphate | 1,3,4-Itp (see all 8) | 98102-63-7 | -- | | Inositol 1,4,5-trisphosphate | 1D-myo-Inositol 1,4,5-trisphosphate (see all 4) | 88269-39-0 | -- | | PI(16:0/16:0) | Phosphatidylinositol(32:0) (see all 8) | -- | -- | | PI(16:0/16:1(9Z)) | Phosphatidylinositol(32:1) (see all 14) | -- | -- | | PI(16:0/16:2(9Z,12Z)) | Phosphatidylinositol(16:0/16:2n4) (see all 18) | -- | -- | | PI(16:0/18:0) | Phosphatidylinositol(16:0/18:0) (see all 8) | -- | -- | | PI(16:0/18:1(11Z)) | Phosphatidylinositol(16:0/18:1w7) (see all 14) | -- | -- | | PI(16:0/18:1(9Z)) | Phosphatidylinositol(16:0/18:1) (see all 14) | -- | -- |
10 Novoseek chemical compound relationships for INPPL1 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| inositol |
85.4 |
31 |
10381377 (2), 15220217 (2), 16842857 (1), 16824732 (1) (see all 22) |
| phosphatidylinositol-3,4,5-trisphosphate |
83.8 |
11 |
12885297 (4), 15668240 (1), 17135240 (1), 15964236 (1) (see all 6) |
| phosphatidylinositol |
69.7 |
18 |
17135240 (3), 15668240 (1), 12351701 (1), 12676785 (1) (see all 11) |
| phosphoinositide |
67.7 |
6 |
17135240 (1), 12769675 (1), 15168016 (1), 15964236 (1) (see all 6) |
| inositol 1,3,4,5-tetrakisphosphate |
58.4 |
2 |
16824732 (1), 10610720 (1) |
| tyrosine |
55.2 |
46 |
10194451 (4), 10381377 (3), 12235291 (3), 18486448 (3) (see all 17) |
| phosphotyrosine |
46.1 |
4 |
10381377 (2), 17938406 (1) |
| lipid |
31.2 |
10 |
16842857 (1), 16824732 (1), 17672824 (1), 19001549 (1) (see all 10) |
| thymidine |
10.1 |
3 |
10381377 (1), 11359765 (1), 14502564 (1) |
| glucose |
3.48 |
4 |
17671700 (2), 16842857 (1) |
Search CenterWatch for drugs/clinical trials and news about INPPL1 / SHIP2
|
Transcripts
for INPPL1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for INPPL1 gene: NM_001567.3 Unigene Cluster for INPPL1: Inositol polyphosphate phosphatase-like 1 Hs.523875 [show with all ESTs]Unigene Representative Sequence: Y1438518 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000540973 ENST00000545256 ENST00000543234 ENST00000298229 ENST00000541544
ENST00000538751(uc001osg.3) ENST00000540329 ENST00000537656 ENST00000538339
ENST00000537755 ENST00000544806 ENST00000541303 ENST00000542295 ENST00000545355
ENST00000535985 ENST00000541752 ENST00000320683 ENST00000541756(uc001osf.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for INPPL1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for INPPL1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: INPPL1 (NM_001567) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for INPPL1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INPPL1 |
Additional cDNA sequence: BC140853.1 L24444.1 L36818.1 Y14385.1 20 DOTS entries: DT.446512 DT.91760060 DT.100792230 DT.97785656 DT.95190629 DT.120744872 DT.120744917 DT.100030826 DT.100792234 DT.317042 DT.70105392 DT.85100069 DT.95352215 DT.95370691 DT.120744923 DT.85100070 DT.95245728 DT.100045872 DT.91760053 DT.95188303 24/475 AceView cDNA sequences (see all 475): Y14385 AW029322 CA389602 AI915012 AW299539 BU159622 AW044313 AL135137 BF063347 BM975689 CO249481 CR591731 BE313364 BI062985 AI077424 AW044430 CD367913 AI475434 BM988739 CB321692 CA314841 AI341923 BE350880 BE797142
GeneLoc Exon Structure
5/21 Alternative Splicing Database (ASD) splice patterns (SP) for INPPL1 (see all 21) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14a | · | 14b | · | 14c | ^ | 15a | · | 15b | ^ | 16a | · | 16b | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | - | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | |
| ExUns: | 16c | ^ | 17a | · | 17b | ^ | 18 | ^ | 19a | · | 19b | ^ | 20a | · | 20b | ^ | 21a | · | 21b | ^ | 22 | ^ | 23a | · | 23b | ^ | 24a | · | 24b | · | 24c | ^ | 25 | ^ | 26a | · | 26b | ^ | 27a | · | 27b | · | 27c | · | 27d | · | 27e | ^ | 28a | · | 28b | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 29a | · | 29b | · | 29c |
|---|
|
| SP1: | | | | | | | |
| SP2: | | | | | | | |
| SP3: | | | | | | | |
| SP4: | | | | | | | |
| SP5: | | | | | | |
ECgene alternative splicing isoforms for INPPL1
|
Expression
for INPPL1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| INPPL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTACCGAGG
About this image
See INPPL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for INPPL1
SOURCE GeneReport for Unigene cluster: Hs.523875
UniProtKB/Swiss-Prot: SHIP2_HUMAN, O15357Tissue specificity: Widely expressed, most prominently in skeletal muscle, heart and brain. Present in platelets.Expressed in transformed myeloid cells and in primary macrophages, but not in peripheral blood monocytes
SABiosciences Expression via Pathway-Focused PCR Array including INPPL1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for INPPL1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat INPPL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INPPL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INPPL1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INPPL1 |
Orthologs
for INPPL1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for INPPL1 gene from 4/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
INPPL16 |
Uncharacterized protein |
58(a) |
1 ↔ 1 |
4(1211412-1218314) |
lizard
(Anolis carolinensis) |
Reptilia |
INPPL16 |
-- |
75(a) |
1 ↔ 1 |
GL344030.1(9126-81749) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.177262 |
Transcribed sequence with moderate similarity to protein more |
77.51(n) |
|
AL956024.2 |
zebrafish
(Danio rerio) |
Actinopterygii |
inppl1a1 |
inositol polyphosphate phosphatase-like 1a |
68.02(n)
70.61(a) |
|
325179 NM_001039804.2 NP_001034893.1 |
ENSEMBL Gene Tree for INPPL1 (if available)
TreeFam Gene Tree for INPPL1 (if available) |
Paralogs
for INPPL1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for INPPL1 gene
- INPP5B2 INPP5J2 SYNJ12 INPP5D2 OCRL2 INPP5K2 INPP5E2 SYNJ22
3 SIMAP similar genes for INPPL1 using alignment to 9 protein entries: SHIP2_HUMAN (see all proteins):SH2D1B SH2D1A INPP5D
INPPL1 for paralogs About GeneDecksing
|
Genomic Variants
for INPPL1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for INPPL1 (71934745 - 71950191 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for INPPL1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing INPPL1 |
|
Disorders
/ Diseases
for INPPL1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
INPPL1 for disorders About GeneDecksing
OMIM gene information: 600829
OMIM disorders: --
UniProtKB/Swiss-Prot: SHIP2_HUMAN, O15357
Defects in INPPL1 may be a cause of susceptibility to type 2 diabetes mellitus non-insulin dependent (NIDDM)[MIM:125853] Note=Genetic variations in INPPL1 may be a cause of susceptibility to metabolic syndrome. Metabolic syndromeis characterized by diabetes, insulin resistance, hypertension, and hypertriglyceridemia is absent
20/23  diseases for INPPL1 (see all 23): About MalaCardsbreast cancer type 2 diabetes mellitus glucose intolerance insulin resistance
oculocerebrorenal syndrome diabetes mellitus urticaria cellulitis
essential hypertension hypertriglyceridemia hyperglycemia obesity
hypertension hepatocellular carcinoma myeloma glioblastoma
esophagitis cholesterol adenocarcinoma carcinoma
1 disease from the University of Copenhagen DISEASES database for INPPL1:Oculocerebrorenal syndrome 6 Novoseek disease relationships for INPPL1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| insulin resistance |
49.7 |
15 |
15654601 (4), 16842857 (2), 14683460 (2), 19272022 (1) (see all 7) |
| insulin sensitivity |
34.9 |
7 |
14683460 (2), 16842857 (1), 15220217 (1) |
| obesity |
30.6 |
10 |
16842857 (2), 17557929 (1), 15964236 (1), 16973905 (1) (see all 5) |
| niddm |
11.8 |
2 |
14683460 (1), 15964236 (1) |
| breast cancer |
0 |
10 |
19082482 (4), 19065064 (3) |
| tumors |
0 |
3 |
14662322 (1), 19082482 (1), 12692707 (1) |
Human Genome Epidemiology (HuGE) Navigator: INPPL1 (5 documents)
Export disorders for INPPL1 gene to outside databases
|
Publications
for INPPL1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for INPPL1 gene, integrated from 9 sources (see all 131):
(articles sorted by number of sources associating them with INPPL1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and characterization of a human cDNA (INPPL1) sharing homology with inositol polyphosphate phosphatases. (PubMed id 8530088)1, 2, 3, 9 Hejna J.A.... Moses R.E. (1995)
- SHIP-2 inositol phosphatase is inducibly expressed in human monocytes and serves to regulate Fcgamma receptor-mediated signaling. (PubMed id 12690104)1, 2, 9 Pengal R.A....Tridandapani S. (2003)
- Genetic association analysis of inositol polyphosphate phosphatase- like 1 (INPPL1, SHIP2) variants with essential hypertension. (PubMed id 17557929)1, 2, 9 Braga Marcano A.C.... Munroe P.B. (2007)
- Src family tyrosine kinases regulate adhesion-dependent tyrosine phosphorylation of 5'-inositol phosphatase SHIP2 during cell attachment and spreading on collagen I. (PubMed id 12235291)1, 2, 9 Prasad N.... Decker S.J. (2002)
- A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5- phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells. (PubMed id 10194451)1, 2, 9 Wisniewski D.... Clarkson B. (1999)
- SH2-containing 5'-inositol phosphatase, SHIP2, regulates cytoskeleton organization and ligand-dependent down-regulation of the epidermal growth factor receptor. (PubMed id 15668240)1, 2, 9 Prasad N.K. and Decker S.J. (2005)
- SH2-containing inositol 5'-phosphatase SHIP2 associates with the p130(Cas) adapter protein and regulates cellular adhesion and spreading. (PubMed id 11158326)1, 2, 9 Prasad N.... Decker S.J. (2001)
- Polymorphisms in type II SH2 domain-containing inositol 5-phosphatase (INPPL1, SHIP2) are associated with physiological abnormalities of the metabolic syndrome. (PubMed id 15220217)1, 2, 9 Kaisaki P.J....Gauguier D. (2004)
- Regulation of PDGF-stimulated SHIP2 tyrosine phosphorylation and association with Shc in 3T3-L1 preadipocytes. (PubMed id 17219406)1, 2, 9 Artemenko Y.... Sorisky A. (2007)
- The Src homology 2 domain containing inositol 5-phosphatase SHIP2 is recruited to the epidermal growth factor (EGF) receptor and dephosphorylates phosphatidylinositol 3,4,5-trisphosphate in EGF- stimulated COS-7 cells. (PubMed id 11349134)1, 2, 9 Pesesse X.... Erneux C. (2001)
|
External Searches for INPPL1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing INPPL1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing INPPL1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing INPPL1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for INPPL1 gene:
Search GeneIP for patents involving INPPL1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for INPPL1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for INPPL1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for INPPL1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for INPPL1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for INPPL1 | | OriGene 3'-UTR Clone for INPPL1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for INPPL1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for INPPL1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat INPPL1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing INPPL1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INPPL1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat INPPL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INPPL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INPPL1 |
| |
 |  |  |  | |
| | Antibodies & Assays for INPPL1 (SHIP-2) |
| | | | Search Tocris compounds for INPPL1 |
| |  |  |  |  | | | | |
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 | | | INPPL1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INPPL1 |
|  |  |  | | | | ThermoFisher Antibody for INPPL1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INPPL1 |
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