Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

INPP5K Gene

protein-coding   GIFtS: 61
GCID: GC17M001397

Inositol Polyphosphate-5-Phosphatase K

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Inositol Polyphosphate-5-Phosphatase K1 2     EC 3.1.3.563 8
SKIP2 3 5     Skeletal Muscle And Kidney Enriched Inositol Phosphatase1
Skeletal Muscle And Kidney-Enriched Inositol Phosphatase2 3     Inositol Polyphosphate 5-Phosphatase K2
PPS2 3     EC 3.1.38

External Ids:    HGNC: 338821   Entrez Gene: 517632   Ensembl: ENSG000001323767   OMIM: 6078755   UniProtKB: Q9BT403   

Export aliases for INPP5K gene to outside databases

Previous GC identifer: GC17M001345


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for INPP5K Gene:
This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to
the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the
actin cytoskeleton. Alternatively spliced transcript variants encoding different isoforms have been identified.
(provided by RefSeq, Oct 2008)

GeneCards Summary for INPP5K Gene: 
INPP5K (inositol polyphosphate-5-phosphatase K) is a protein-coding gene. Diseases associated with INPP5K include oculocerebrorenal syndrome, and miller-dieker syndrome, and among its related super-pathways are Phosphatidylinositol signaling system and Metabolic pathways. GO annotations related to this gene include inositol-1,4,5-trisphosphate 5-phosphatase activity and inositol-polyphosphate 5-phosphatase activity. An important paralog of this gene is INPP5B.

UniProtKB/Swiss-Prot: INP5K_HUMAN, Q9BT40
Function: Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate,
phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has 6-fold higher affinity
for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate. May negatively regulate assembly
of the actin cytoskeleton

Gene Wiki entry for INPP5K (SKIP) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010718.16  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the INPP5K gene promoter:
         HOXA9B   HOXA9   MIF-1   E47   RORalpha2   FOXC1   Meis-1a   Pax-4a   ATF   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidINPP5K promoter sequence
   Search SABiosciences Chromatin IP Primers for INPP5K

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INPP5K


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.3   Ensembl cytogenetic band:  17p13.3   HGNC cytogenetic band: 17p13.3

INPP5K Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INPP5K gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M001397:  view genomic region     (about GC identifiers)

Start:
1,397,865 bp from pter      End:
1,420,182 bp from pter
Size:
22,318 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: INP5K_HUMAN, Q9BT40 (See protein sequence)
Recommended Name: Inositol polyphosphate 5-phosphatase K  
Size: 448 amino acids; 51090 Da
Subcellular location: Endoplasmic reticulum. Note=Following stimulation with EGF, translocates to membrane ruffles
Secondary accessions: B2R6I2 B2R750 D3DTH8 Q15733 Q9NPJ5 Q9P2R5
Alternative splicing: 2 isoforms:  Q9BT40-1   Q9BT40-2   

Explore the universe of human proteins at neXtProt for INPP5K: NX_Q9BT40

Explore proteomics data for INPP5K at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BT40

  • 4 DME Specific Peptides for INPP5K (Q9BT40)
     WDWIGLY  LWEKDQL  FPPTYKF  KKRKPAWTDRILW 

    INPP5K Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    INPP5K Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001129114.1  NP_057616.2  NP_570122.1  

    ENSEMBL proteins: 
     ENSP00000413937   ENSP00000385177   ENSP00000318476   ENSP00000254712   ENSP00000461105  
     ENSP00000413259   ENSP00000459758   ENSP00000466632   ENSP00000461846   ENSP00000458413  
     ENSP00000389334   ENSP00000467376   ENSP00000466929   ENSP00000459029   ENSP00000440147  
     ENSP00000380496  
    Reactome Protein details: Q9BT40
    Human Recombinant Protein Products for INPP5K: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for INPP5K
    OriGene Protein Over-expression Lysate for INPP5K
    OriGene MassSpec for INPP5K 
    OriGene Custom Protein Services for INPP5K
    GenScript Custom Purified and Recombinant Proteins Services for INPP5K
    Novus Biologicals INPP5K Proteins
    Novus Biologicals INPP5K Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for INPP5K 

    Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle IDA12536145
    GO:0005634nucleus IDA18774950
    GO:0005737cytoplasm ISS--
    GO:0005783endoplasmic reticulum IDA12536145
    GO:0005802trans-Golgi network IDA12556481

    INPP5K for ontologies           About GeneDecksing



    INPP5K Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for INPP5K
    GenScript Custom Superior Antibodies Services for INPP5K
    Novus Biologicals INPP5K Antibodies
    Abcam antibodies for INPP5K
    Cloud-Clone Corp. Antibodies for INPP5K 
    ThermoFisher Antibody for INPP5K
    LSBio Antibodies in human, mouse, rat for INPP5K 

    Assay Products for INPP5K: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for INPP5K
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for INPP5K
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for INPP5K 
    Cloud-Clone Corp. CLIAs for INPP5K


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: INPP5K 
    Inositol polyphosphate phosphatases

    2 InterPro protein domains:
     IPR000300 IPPc
     IPR005135 Endo/exonuclease/phosphatase

    Graphical View of Domain Structure for InterPro Entry Q9BT40

    ProtoNet protein and cluster: Q9BT40

    1 Blocks protein domain: IPB000300 Inositol polyphosphate related phosphatase family

    UniProtKB/Swiss-Prot: INP5K_HUMAN, Q9BT40
    Similarity: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family


    INPP5K for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: INP5K_HUMAN, Q9BT40
    Function: Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate,
    phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has 6-fold higher affinity
    for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate. May negatively regulate assembly
    of the actin cytoskeleton
    Catalytic activity: D-myo-inositol 1,4,5-trisphosphate + H(2)O = myo-inositol 1,4-bisphosphate + phosphate

         Enzyme Numbers (IUBMB): EC 3.1.3.561 2 EC 3.1.32

         Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004445inositol-polyphosphate 5-phosphatase activity IEA--
    GO:0005000vasopressin receptor activity ISS--
    GO:0005515protein binding IPI16002321
    GO:0016312inositol bisphosphate phosphatase activity IDA10753883
    GO:0034485phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity IDA--
         
    INPP5K for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for INPP5K:
     Decreased nuclei size in G2M  Decreased viability 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Inpp5k):
     growth/size  homeostasis/metabolism  mortality/aging  muscle 

    INPP5K for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for INPP5K 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for INPP5K

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for INPP5K 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for INPP5K 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat INPP5K
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate INPP5K (see all 13):
    hsa-miR-455-5p hsa-miR-550a hsa-miR-548d-3p hsa-miR-3675-5p hsa-miR-520a-5p hsa-miR-1227 hsa-miR-221* hsa-miR-4253
    SwitchGear 3'UTR luciferase reporter plasmidINPP5K 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for INPP5K
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat INPP5K

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for INPP5K
    Sirion Biotech Customized adenovirus for overexpression of INPP5K

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for INPP5K (see all 20)
    OriGene ORF clones in mouse, rat for INPP5K
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): INPP5K (NM_130766)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INPP5K
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INPP5K
    Sirion Biotech Customized lentivirus for stable overexpression of INPP5K 
                         Customized lentivirus expression plasmids for stable overexpression of INPP5K 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for INPP5K
    Search LifeMap BioReagents cell lines for INPP5K
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INPP5K


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for INPP5K About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Inositol phosphate metabolism
    Inositol phosphate metabolism0.61
    superpathway of inositol phosphate compounds0.60
    Phosphatidylinositol signaling system0.61
    2Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    Metabolic pathways0.40
    3D-myo-inositol (1,3,4)-trisphosphate biosynthesis
    D-myo-inositol (1,3,4)-trisphosphate biosynthesis0.76
    D-myo-inositol (1,4,5)-trisphosphate degradation0.65
    1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)0.76
    3-phosphoinositide degradation0.33
    superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism0.75
    4PI Metabolism
    PI Metabolism0.66
    Synthesis of PIPs at the plasma membrane0.66
    5Notch signaling pathway
    Notch Signaling Pathway0.84

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/7 BioSystems Pathways for INPP5K (see all 7)
        Notch Signaling Pathway
    D-myo-inositol (1,4,5)-trisphosphate degradation
    1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)
    D-myo-inositol (1,3,4)-trisphosphate biosynthesis
    superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism

    5        Reactome Pathways for INPP5K
        Metabolism
    Synthesis of PIPs at the plasma membrane
    Phospholipid metabolism
    Metabolism of lipids and lipoproteins
    PI Metabolism


    4         Kegg Pathways  (Kegg details for INPP5K):
        Inositol phosphate metabolism
    Metabolic pathways
    Phosphatidylinositol signaling system
    Insulin signaling pathway


    INPP5K for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for INPP5K

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/50 Interacting proteins for INPP5K (Q9BT401, 2, 3 ENSP000002547124) via UniProtKB, MINT, STRING, and/or I2D (see all 50)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARL6IP1Q150412, 3, ENSP000003067884MINT-67457 I2D: score=5 STRING: ENSP00000306788
    SMN1Q166372, 3MINT-8271234 I2D: score=2 
    SMN2Q166372, 3MINT-8271234 I2D: score=2 
    LNX1Q8TBB11, 3, ENSP000002639254EBI-749162,EBI-739832 I2D: score=1 STRING: ENSP00000263925
    ANXA7P200732, 3MINT-8248472 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/39 biological process terms (GO ID links to tree view) (see all 39):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0001933negative regulation of protein phosphorylation ISS--
    GO:0005979regulation of glycogen biosynthetic process ISS--
    GO:0006469negative regulation of protein kinase activity IDA12556481
    GO:0006644phospholipid metabolic process TAS--

    INPP5K for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    INPP5K for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for INPP5K (INP5K)

    6 HMDB Compounds for INPP5K    About this table
    CompoundSynonyms CAS #PubMed Ids
    1D-Myo-inositol 1,4-bisphosphate1D-Myo-inositol 1,4-bisphosphate (see all 5)47055-78-7--
    Inositol 1,3,4,5-tetraphosphate1,3,4,5-tetrakis(dihydrogen phosphate) myo-Inositol (see all 16)102850-29-3--
    Inositol 1,3,4-trisphosphate1,3,4-Itp (see all 8)98102-63-7--
    Inositol 1,4,5-trisphosphate1D-myo-Inositol 1,4,5-trisphosphate (see all 4)88269-39-0--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    6 Novoseek inferred chemical compound relationships for INPP5K gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphatidylinositol-3,4,5-trisphosphate 84.9 3 12536145 (1), 18573875 (1), 12556481 (1)
    inositol 81.6 17 10753883 (2), 16842857 (1), 12536145 (1), 16824732 (1) (see all 8)
    inositol 1,3,4,5-tetrakisphosphate 78.5 1 10753883 (1)
    phosphatidylinositol 46.5 6 10753883 (2), 18573875 (1)
    lipid 34.9 1 16842857 (1)
    glucose 28 5 16842857 (2), 19272022 (1), 12556481 (1)

    Search CenterWatch for drugs/clinical trials and news about INPP5K / INP5K

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for INPP5K gene (3 alternative transcripts): 
    NM_001135642.1  NM_016532.3  NM_130766.2  

    Unigene Cluster for INPP5K:

    Inositol polyphosphate-5-phosphatase K
    Hs.632238  [show with all ESTs]
    Unigene Representative Sequence: NM_001135642
    18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000421807(uc002fsr.3 uc010cjr.3 uc010vql.2 uc010vqm.2 uc010cjs.2)
    ENST00000406424(uc002fss.3 uc002fsq.3) ENST00000320345 ENST00000350761
    ENST00000487039 ENST00000574561 ENST00000461552 ENST00000495339 ENST00000449479
    ENST00000481867 ENST00000477115 ENST00000575172 ENST00000576646 ENST00000573790
    ENST00000460733 ENST00000571274 ENST00000445774 ENST00000477910
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat INPP5K
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate INPP5K (see all 13):
    hsa-miR-455-5p hsa-miR-550a hsa-miR-548d-3p hsa-miR-3675-5p hsa-miR-520a-5p hsa-miR-1227 hsa-miR-221* hsa-miR-4253
    SwitchGear 3'UTR luciferase reporter plasmidINPP5K 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for INPP5K
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat INPP5K
    Clone
    Products:
         
    OriGene clones in human, mouse for INPP5K (see all 20)
    OriGene ORF clones in mouse, rat for INPP5K
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): INPP5K (NM_130766)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INPP5K
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INPP5K
    Sirion Biotech Customized lentivirus for stable overexpression of INPP5K 
                         Customized lentivirus expression plasmids for stable overexpression of INPP5K 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for INPP5K
    OriGene qSTAR qPCR primer pairs in human, mouse for INPP5K
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat INPP5K
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INPP5K
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INPP5K

    Additional mRNA sequence: 

    AB036829.1 AB036830.1 AK297955.1 AK303907.1 AK312585.1 AK312844.1 BC004362.1 U45973.1 

    13 DOTS entries:

    DT.95185600  DT.418018  DT.40117980  DT.95185582  DT.92469550  DT.100794853  DT.91826905  DT.95185587 
    DT.100794855  DT.95185585  DT.120983345  DT.100706777  DT.91666722 

    24/280 AceView cDNA sequences (see all 280):

    AA283094 BQ061224 AW140051 BX118438 BU176741 BM669078 BQ057001 BM557111 
    BM672230 BC004362 CD107438 BU175381 BM710004 AA847653 CB154057 BU541287 
    AA747853 BM725656 BI824023 CR596159 AI143336 BM708936 AA282930 BM704724 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for INPP5K (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^
    SP1:                                                                                                                    -                                       
    SP2:                                                  -     -     -                 -                                   -                                       
    SP3:                                                  -     -     -           -     -                                   -                                       
    SP4:                                                              -                 -                                   -                                       
    SP5:                                                                                                                    -                                       

    ExUns: 12 ^ 13 ^ 14 ^ 15
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for INPP5K

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    INPP5K expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGGCTGTT
    INPP5K Expression
    About this image


    See INPP5K Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for INPP5K

    SOURCE GeneReport for Unigene cluster: Hs.632238

    UniProtKB/Swiss-Prot: INP5K_HUMAN, Q9BT40
    Tissue specificity: Ubiquitously expressed with highest levels in skeletal muscle, heart and kidney

        SABiosciences Custom PCR Arrays for INPP5K
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for INPP5K
    OriGene qSTAR qPCR primer pairs in human, mouse for INPP5K
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat INPP5K
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INPP5K
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INPP5K
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INPP5K

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for INPP5K gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Inpp5k1 , 5 inositol polyphosphate 5-phosphatase K1, 5 80.58(n)1
    75.89(a)1
      11 (45.92 cM)5
    190621  NM_008916.21  NP_032942.11 
     756309885 
    chicken
    (Gallus gallus)
    Aves INPP5K1 inositol polyphosphate-5-phosphatase K 62.55(n)
    57.96(a)
      771549  XM_001234812.2  XP_001234813.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    56(a)
    56(a)
    1 ↔ many
    1 ↔ many
    AAWZ02039565(1027-4608)
    AAWZ02039501(2203-5738)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.143382 Xenopus laevis transcribed sequence with weak similarity more 73.09(n)    CF287087.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1628831 zgc:162883 58.31(n)
    49.4(a)
      100037338  NM_001089493.1  NP_001082962.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG68051 CG6805 50.62(n)
    40.68(a)
      36911  NM_137334.3  NP_611178.1 


    ENSEMBL Gene Tree for INPP5K (if available)
    TreeFam Gene Tree for INPP5K (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for INPP5K gene
    INPP5B2  INPP5J2  SYNJ12  OCRL2  INPP5D2  INPP5E2  INPPL12  SYNJ22  
    2 SIMAP similar genes for INPP5K using alignment to 14 protein entries:     INP5K_HUMAN (see all proteins):
    INPP5J    SYNJ1

    INPP5K for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/661 SNPs in INPP5K are shown (see all 661)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0364974
    A breast cancer sample4--see VAR_0364972 S F mis40--------
    rs1414057611,2
    --1319446(+) CGATTA/GGCGTT 3 -- int1 ut510--------
    rs1470135281,2
    --1319475(+) GGCAAC/GAGACC 3 -- int1 ut510--------
    rs1168972171,2
    C,F--1319566(+) CCTGAT/AGTATG 3 -- int1 ut511Minor allele frequency- A:0.01NA 120
    rs1479768221,2
    --1319584(+) GAAAAA/GTAGGA 3 -- int10--------
    rs1407359911,2
    --1319597(+) AAGATG/TTCTAA 3 -- int10--------
    rs1828536101,2
    --1319874(+) TCCCCA/CCGAGC 3 -- int10--------
    rs1164510021,2
    C,F--1319900(+) GCCAGG/CGTGCC 3 -- int11Minor allele frequency- C:0.09WA 118
    rs2019648531,2
    C,F--1319958(+) ATGGCC/TGCCGT 3 -- ut511Minor allele frequency- T:0.01EU 155
    rs1995192791,2
    --1319983(+) GGTCCG/TGCAGG 3 -- ut510--------

    HapMap Linkage Disequilibrium report for INPP5K (1397865 - 1420182 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for INPP5K:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2715465CNV Deletion23290073
    esv2715466CNV Deletion23290073
    dgv3029n71CNV Loss21882294
    nsv907502CNV Loss21882294
    dgv3028n71CNV Loss21882294
    nsv907504CNV Loss21882294
    nsv833334CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing INPP5K
    DNA2.0 Custom Variant and Variant Library Synthesis for INPP5K

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607875    OMIM disorders: --

    7 diseases for INPP5K:    About MalaCards
    oculocerebrorenal syndrome    miller-dieker syndrome    lissencephaly    obesity
    hepatitis b    hepatitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for INPP5K:
    Oculocerebrorenal syndrome

    INPP5K for disorders           About GeneDecksing


    Export disorders for INPP5K gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for INPP5K gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with INPP5K)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel domain in two mammalian inositol- polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase SKIP localizes to the endoplasmic reticulum and translocates to membrane ruffles following epidermal growth factor stimulation. (PubMed id 12536145)1, 2, 3, 9 Gurung R.... Mitchell C.A. (2003)
    2. Identification and characterization of a novel inositol polyphosphate 5-phosphatase. (PubMed id 10753883)1, 2, 3, 9 Ijuin T.... Takenawa T. (2000)
    3. SKIP negatively regulates insulin-induced GLUT4 translocation and membrane ruffle formation. (PubMed id 12556481)1, 9 Ijuin T. and Takenawa T. (2003)
    4. Suppression of hepatitis B viral gene expression by phosphoinositide 5-phosphatase SKIP. (PubMed id 18774950)1, 9 Hung C.S....Ting L.P. (2009)
    5. Increased insulin action in SKIP heterozygous knockout mice. (PubMed id 18573875)1, 9 Ijuin T....Takenawa T. (2008)
    6. Role of phosphatidylinositol 3,4,5-trisphosphate (PIP3 ) 5-phosphatase skeletal muscle- and kidney-enriched inositol polyphosphate phos phatase (SKIP) in myoblast differentiation. (PubMed id 22815484)1 Ijuin T. and Takenawa T. (2012)
    7. Regulation of insulin signaling by the phosphatidylino sitol 3,4,5-triphosphate phosphatase SKIP through the scaffolding function of Pa k1. (PubMed id 22751929)1 Ijuin T. and Takenawa T. (2012)
    8. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S....Dorf M.E. (2011)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51763 HGNC: 33882 AceView: SKIP Ensembl:ENSG00000132376 euGenes: HUgn51763
    ECgene: INPP5K Kegg: 51763 H-InvDB: INPP5K

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for INPP5K Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for INPP5K gene:
    Search GeneIP for patents involving INPP5K

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for INPP5K  
     OriGene qPCR primer pairs and template standards for INPP5K   OriGene Protein Over-expression Lysate for INPP5K  
     OriGene MassSpec something-or-other for INPP5K   OriGene clones in human, mouse for INPP5K  
     OriGene qSTAR qPCR primer pairs in human, mouse for INPP5K   OriGene Purified Protein for INPP5K  
     OriGene ORF clones in mouse, rat for INPP5K   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for INPP5K   OriGene Custom Protein Services for INPP5K  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat INPP5K
     QIAGEN SeqTarget long-range PCR primers for resequencing INPP5K
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INPP5K
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat INPP5K
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INPP5K
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INPP5K
     GenScript Custom Purified and Recombinant Proteins Services for INPP5K GenScript cDNA clones with any tag delivered in your preferred vector for INPP5K
     GenScript Custom Assay Services for INPP5K GenScript Custom Superior Antibodies Services for INPP5K
     GenScript Custom overexpressing Cell Line Services for INPP5K CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in INPP5K promoter
     Search Chromatin IP Primers for INPP5K
     RT2 qPCR Primer Assay in human, mouse, rat INPP5K
     Search GNC Networks for INPP5K
     SABiosciences Custom PCR Arrays for INPP5K
     Search Tocris compounds for INPP5K (INP5K)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     INPP5K antibodies
     INPP5K proteins
     INPP5K lysates
     Antibodies for INPP5K
     See all of Abcam's Antibodies, Kits and Proteins for INPP5K
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for INPP5K
     Antibodies for INPP5K
     ELISAs for INPP5K
     CLIAs for INPP5K
     Search LifeMap BioReagents cell lines for INPP5K
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INPP5K
     SwitchGear 3'UTR luciferase reporter plasmids for INPP5K
     SwitchGear Promoter luciferase reporter plasmids for INPP5K
     ThermoFisher Antibody for INPP5K
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INPP5K
     inGenious Targeting Laboratory - Custom generated mouse model solutions for INPP5K
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for INPP5K
    Customized:
     lentivirus for stable overexpression of INPP5K
     lentivirus expression plasmids for stable overexpression of INPP5K
     adenovirus for overexpression of INPP5K
     LSBio Antibodies in human, mouse, rat for INPP5K
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      INPP5K gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4