Aliases for INPP5K Gene
External Ids for INPP5K Gene
Previous GeneCards Identifiers for INPP5K Gene
This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]
GeneCards Summary for INPP5K Gene
INPP5K (Inositol Polyphosphate-5-Phosphatase K) is a Protein Coding gene. Among its related pathways are Inositol phosphate metabolism (KEGG) and Notch signaling pathway (KEGG). GO annotations related to this gene include vasopressin receptor activity and lipid phosphatase activity. An important paralog of this gene is INPP5J.
UniProtKB/Swiss-Prot for INPP5K Gene
Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate. May negatively regulate assembly of the actin cytoskeleton.