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Aliases for INPP5K Gene

Aliases for INPP5K Gene

  • Inositol Polyphosphate-5-Phosphatase K 2 3
  • SKIP 3 4 6
  • Skeletal Muscle And Kidney-Enriched Inositol Phosphatase 3 4
  • EC 3.1.3.56 4 63
  • PPS 3 4
  • Skeletal Muscle And Kidney Enriched Inositol Phosphatase 2
  • Inositol Polyphosphate 5-Phosphatase K 3
  • EC 3.1.3 63

External Ids for INPP5K Gene

Summaries for INPP5K Gene

Entrez Gene Summary for INPP5K Gene

  • This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]

GeneCards Summary for INPP5K Gene

INPP5K (Inositol Polyphosphate-5-Phosphatase K) is a Protein Coding gene. Diseases associated with INPP5K include oculocerebrorenal syndrome and miller-dieker syndrome. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include inositol-polyphosphate 5-phosphatase activity and inositol-1,4,5-trisphosphate 5-phosphatase activity. An important paralog of this gene is SYNJ2.

UniProtKB/Swiss-Prot for INPP5K Gene

  • Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate. May negatively regulate assembly of the actin cytoskeleton.

Gene Wiki entry for INPP5K Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INPP5K Gene

Genomics for INPP5K Gene

Genomic Location for INPP5K Gene

Start:
1,494,571 bp from pter
End:
1,516,888 bp from pter
Size:
22,318 bases
Orientation:
Minus strand

Genomic View for INPP5K Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for INPP5K Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INPP5K Gene

Regulatory Elements for INPP5K Gene

Proteins for INPP5K Gene

  • Protein details for INPP5K Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BT40-INP5K_HUMAN
    Recommended name:
    Inositol polyphosphate 5-phosphatase K
    Protein Accession:
    Q9BT40
    Secondary Accessions:
    • B2R6I2
    • B2R750
    • D3DTH8
    • Q15733
    • Q9NPJ5
    • Q9P2R5

    Protein attributes for INPP5K Gene

    Size:
    448 amino acids
    Molecular mass:
    51090 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for INPP5K Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for INPP5K Gene

Proteomics data for INPP5K Gene at MOPED

Selected DME Specific Peptides for INPP5K Gene

Post-translational modifications for INPP5K Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for INPP5K Gene

Gene Families for INPP5K Gene

Protein Domains for INPP5K Gene

Graphical View of Domain Structure for InterPro Entry

Q9BT40

UniProtKB/Swiss-Prot:

INP5K_HUMAN
Family:
  • Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.:
    • Q9BT40
genes like me logo Genes that share domains with INPP5K: view

Function for INPP5K Gene

Molecular function for INPP5K Gene

UniProtKB/Swiss-Prot CatalyticActivity: D-myo-inositol 1,4,5-trisphosphate + H(2)O = myo-inositol 1,4-bisphosphate + phosphate.
UniProtKB/Swiss-Prot Function: Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate. May negatively regulate assembly of the actin cytoskeleton.

Enzyme Numbers (IUBMB) for INPP5K Gene

Gene Ontology (GO) - Molecular Function for INPP5K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004445 inositol-polyphosphate 5-phosphatase activity IEA --
GO:0005000 vasopressin receptor activity ISS --
GO:0005515 protein binding IPI 16002321
GO:0016312 inositol bisphosphate phosphatase activity IDA 10753883
GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity IDA 21712384
genes like me logo Genes that share ontologies with INPP5K: view

Phenotypes for INPP5K Gene

genes like me logo Genes that share phenotypes with INPP5K: view

miRNA for INPP5K Gene

miRTarBase miRNAs that target INPP5K

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for INPP5K Gene

Localization for INPP5K Gene

Subcellular locations from UniProtKB/Swiss-Prot for INPP5K Gene

Endoplasmic reticulum. Note=Following stimulation with EGF, translocates to membrane ruffles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for INPP5K Gene COMPARTMENTS Subcellular localization image for INPP5K gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
nucleus 5
plasma membrane 5
mitochondrion 2

Gene Ontology (GO) - Cellular Components for INPP5K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IDA 12536145
GO:0005634 nucleus IDA 18774950
GO:0005737 cytoplasm ISS --
GO:0005783 endoplasmic reticulum IDA 12536145
GO:0005802 trans-Golgi network IDA 12556481
genes like me logo Genes that share ontologies with INPP5K: view

Pathways for INPP5K Gene

genes like me logo Genes that share pathways with INPP5K: view

Gene Ontology (GO) - Biological Process for INPP5K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0001933 negative regulation of protein phosphorylation ISS --
GO:0005979 regulation of glycogen biosynthetic process ISS --
GO:0006469 negative regulation of protein kinase activity IDA 12556481
GO:0006644 phospholipid metabolic process TAS --
genes like me logo Genes that share ontologies with INPP5K: view

Compounds for INPP5K Gene

(6) HMDB Compounds for INPP5K Gene

Compound Synonyms Cas Number PubMed IDs
1D-Myo-inositol 1,4-bisphosphate
  • 1D-Myo-inositol 1,4-bisphosphate
47055-78-7
Inositol 1,3,4,5-tetraphosphate
  • 1,3,4,5-tetrakis(dihydrogen phosphate) myo-Inositol
102850-29-3
Inositol 1,3,4-trisphosphate
  • 1,3,4-Itp
98102-63-7
Inositol 1,4,5-trisphosphate
  • 1D-myo-Inositol 1,4,5-trisphosphate
88269-39-0
Phosphate
  • NFB Orthophosphate
14265-44-2

(6) Novoseek inferred chemical compound relationships for INPP5K Gene

Compound -log(P) Hits PubMed IDs
phosphatidylinositol-3,4,5-trisphosphate 84.9 3
inositol 81.6 9
inositol 1,3,4,5-tetrakisphosphate 78.5 1
phosphatidylinositol 46.5 3
lipid 34.9 1
genes like me logo Genes that share compounds with INPP5K: view

Transcripts for INPP5K Gene

Unigene Clusters for INPP5K Gene

Inositol polyphosphate-5-phosphatase K:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for INPP5K Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^
SP1: -
SP2: - - - - -
SP3: - - - - - -
SP4: - - -
SP5: -
SP6: -
SP7: - - - - -
SP8: - -
SP9: - -
SP10: - - - - -
SP11: - - -
SP12: - - -
SP13: - - - - - - - - - - - - - - - -
SP14: -

ExUns: 12 ^ 13 ^ 14 ^ 15
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for INPP5K Gene

GeneLoc Exon Structure for
INPP5K
ECgene alternative splicing isoforms for
INPP5K

Expression for INPP5K Gene

mRNA expression in normal human tissues for INPP5K Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for INPP5K Gene

SOURCE GeneReport for Unigene cluster for INPP5K Gene Hs.632238

mRNA Expression by UniProt/SwissProt for INPP5K Gene

Q9BT40-INP5K_HUMAN
Tissue specificity: Ubiquitously expressed with highest levels in skeletal muscle, heart and kidney.
genes like me logo Genes that share expressions with INPP5K: view

No data available for mRNA differential expression in normal tissues for INPP5K Gene

Orthologs for INPP5K Gene

This gene was present in the common ancestor of animals.

Orthologs for INPP5K Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INPP5K 35
  • 99.26 (n)
  • 98.88 (a)
INPP5K 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia INPP5K 35
  • 84.39 (n)
  • 78.4 (a)
INPP5K 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia INPP5K 35
  • 85.14 (n)
  • 79.05 (a)
INPP5K 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Inpp5k 35
  • 80.58 (n)
  • 75.89 (a)
Inpp5k 16
Inpp5k 36
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia INPP5K 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia INPP5K 36
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Inpp5k 35
  • 81.36 (n)
  • 76.14 (a)
chicken
(Gallus gallus)
Aves INPP5K 35
  • 62.4 (n)
  • 57.58 (a)
INPP5K 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 56 (a)
OneToMany
-- 36
  • 55 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.14338 35
tropical clawed frog
(Silurana tropicalis)
Amphibia inpp5k 35
  • 60.7 (n)
  • 56.2 (a)
zebrafish
(Danio rerio)
Actinopterygii inpp5k 36
  • 40 (a)
OneToMany
INPP5K (1 of 2) 36
  • 44 (a)
OneToMany
zgc:162883 35
  • 57.32 (n)
  • 48.22 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6805 36
  • 35 (a)
ManyToMany
CG9784 36
  • 27 (a)
ManyToMany
Species with no ortholog for INPP5K:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for INPP5K Gene

ENSEMBL:
Gene Tree for INPP5K (if available)
TreeFam:
Gene Tree for INPP5K (if available)

Paralogs for INPP5K Gene

Paralogs for INPP5K Gene

genes like me logo Genes that share paralogs with INPP5K: view

Variants for INPP5K Gene

Sequence variations from dbSNP and Humsavar for INPP5K Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs14391 -- 1,495,006(-) CAGGT(G/T)AGGTG utr-variant-3-prime
rs873179 -- 1,506,593(-) AAGGA(C/T)GCCTG intron-variant
rs939562 -- 1,497,598(+) GGAGC(A/G)CCCGT intron-variant
rs939563 -- 1,512,616(+) TTTCA(A/T)TCCTC intron-variant
rs1059139 -- 1,494,976(-) AGGAG(A/C/G/T)CATTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for INPP5K Gene

Variant ID Type Subtype PubMed ID
nsv833334 CNV Loss 17160897
dgv3028n71 CNV Loss 21882294
nsv907502 CNV Loss 21882294
dgv3029n71 CNV Loss 21882294
nsv907504 CNV Loss 21882294
esv2715465 CNV Deletion 23290073
esv2715466 CNV Deletion 23290073

Relevant External Links for INPP5K Gene

HapMap Linkage Disequilibrium report
INPP5K
Human Gene Mutation Database (HGMD)
INPP5K

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INPP5K Gene

Disorders for INPP5K Gene

(1) University of Copenhagen DISEASES for INPP5K Gene

genes like me logo Genes that share disorders with INPP5K: view

No data available for UniProtKB/Swiss-Prot for INPP5K Gene

Publications for INPP5K Gene

  1. Identification and characterization of a novel inositol polyphosphate 5-phosphatase. (PMID: 10753883) Ijuin T. … Takenawa T. (J. Biol. Chem. 2000) 2 3 4 23
  2. Identification of a novel domain in two mammalian inositol- polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase SKIP localizes to the endoplasmic reticulum and translocates to membrane ruffles following epidermal growth factor stimulation. (PMID: 12536145) Gurung R. … Mitchell C.A. (J. Biol. Chem. 2003) 2 3 4 23
  3. SKIP negatively regulates insulin-induced GLUT4 translocation and membrane ruffle formation. (PMID: 12556481) Ijuin T. … Takenawa T. (Mol. Cell. Biol. 2003) 3 23
  4. Increased insulin action in SKIP heterozygous knockout mice. (PMID: 18573875) Ijuin T. … Takenawa T. (Mol. Cell. Biol. 2008) 3 23
  5. Suppression of hepatitis B viral gene expression by phosphoinositide 5-phosphatase SKIP. (PMID: 18774950) Hung C.S. … Ting L.P. (Cell. Microbiol. 2009) 3 23

Products for INPP5K Gene

Sources for INPP5K Gene

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