Free for academic non-profit institutions. Other users need a Commercial license

Aliases for INPP5K Gene

Aliases for INPP5K Gene

  • Inositol Polyphosphate-5-Phosphatase K 2 3 5
  • Skeletal Muscle And Kidney-Enriched Inositol Phosphatase 3 4
  • EC 3.1.3.56 4 61
  • SKIP 3 4
  • PPS 3 4
  • Skeletal Muscle And Kidney Enriched Inositol Phosphatase 2
  • Inositol Polyphosphate 5-Phosphatase K 3
  • EC 3.1.3 61

External Ids for INPP5K Gene

Previous GeneCards Identifiers for INPP5K Gene

  • GC17M001345
  • GC17M001397

Summaries for INPP5K Gene

Entrez Gene Summary for INPP5K Gene

  • This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]

GeneCards Summary for INPP5K Gene

INPP5K (Inositol Polyphosphate-5-Phosphatase K) is a Protein Coding gene. Among its related pathways are Metabolism and Inositol phosphate metabolism (KEGG). GO annotations related to this gene include vasopressin receptor activity and lipid phosphatase activity. An important paralog of this gene is INPP5J.

UniProtKB/Swiss-Prot for INPP5K Gene

  • Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate. May negatively regulate assembly of the actin cytoskeleton.

Gene Wiki entry for INPP5K Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INPP5K Gene

Genomics for INPP5K Gene

Regulatory Elements for INPP5K Gene

Enhancers for INPP5K Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F001554 1.1 FANTOM5 Ensembl ENCODE 19.2 -39.9 -39880 3.7 KLF17 RAD21 THRB YY1 RARA ZNF121 SCRT2 ETV6 FOS USF2 PITPNA INPP5K PITPNA-AS1 YWHAE SLC43A2 SCARF1 CRK WDR81 PIR42053
GH17F001473 1.2 Ensembl ENCODE 13.1 +42.7 42716 2.2 HDGF PKNOX1 SIN3A FEZF1 RAD21 ZNF121 ZNF366 EGR1 CREM EGR2 INPP5K PITPNA-AS1 YWHAE CRK LOC100294336 GC17M001459
GH17F001446 0.5 Ensembl ENCODE 12.1 +69.6 69590 1.8 ZBTB33 PRDM1 NR2F2 YWHAE INPP5K PITPNA-AS1 MYO1C CRK PITPNA LOC101929775
GH17F001437 0.5 Ensembl ENCODE 12 +77.9 77913 2.1 HDAC1 BMI1 ETV6 CREM ZNF362 CBFB JUNB TBX21 THRAP3 IKZF1 MYO1C CRK RPA1 SMYD4 YWHAE GEMIN4 INPP5K PITPNA-AS1 PITPNA LOC101929775
GH17F001379 1.4 Ensembl ENCODE 11.6 +136.8 136788 1.4 ZNF263 BCOR ZNF362 USF2 RELA ZNF664 ZNF121 ZNF707 RAD51 IKZF1 YWHAE INPP5K PITPNA-AS1 MYO1C CRK GC17P001386 ENSG00000280408
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around INPP5K on UCSC Golden Path with GeneCards custom track

Promoters for INPP5K Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001338799 188 2201 PKNOX1 MLX ZFP64 ARID4B SIN3A ZNF2 YY1 SLC30A9 ZNF143 KLF13

Genomic Location for INPP5K Gene

Chromosome:
17
Start:
1,494,571 bp from pter
End:
1,516,888 bp from pter
Size:
22,318 bases
Orientation:
Minus strand

Genomic View for INPP5K Gene

Genes around INPP5K on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INPP5K Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INPP5K Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INPP5K Gene

Proteins for INPP5K Gene

  • Protein details for INPP5K Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BT40-INP5K_HUMAN
    Recommended name:
    Inositol polyphosphate 5-phosphatase K
    Protein Accession:
    Q9BT40
    Secondary Accessions:
    • B2R6I2
    • B2R750
    • D3DTH8
    • Q15733
    • Q9NPJ5
    • Q9P2R5

    Protein attributes for INPP5K Gene

    Size:
    448 amino acids
    Molecular mass:
    51090 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for INPP5K Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for INPP5K Gene

Selected DME Specific Peptides for INPP5K Gene

Post-translational modifications for INPP5K Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for INPP5K Gene

Gene Families for INPP5K Gene

Protein Domains for INPP5K Gene

Graphical View of Domain Structure for InterPro Entry

Q9BT40

UniProtKB/Swiss-Prot:

INP5K_HUMAN :
  • Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.
Family:
  • Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.
genes like me logo Genes that share domains with INPP5K: view

Function for INPP5K Gene

Molecular function for INPP5K Gene

UniProtKB/Swiss-Prot CatalyticActivity:
D-myo-inositol 1,4,5-trisphosphate + H(2)O = myo-inositol 1,4-bisphosphate + phosphate.
UniProtKB/Swiss-Prot Function:
Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate. May negatively regulate assembly of the actin cytoskeleton.

Enzyme Numbers (IUBMB) for INPP5K Gene

Gene Ontology (GO) - Molecular Function for INPP5K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity TAS --
GO:0004445 inositol-polyphosphate 5-phosphatase activity IEA --
GO:0005000 vasopressin receptor activity ISS --
GO:0005515 protein binding IPI 16002321
GO:0016312 inositol bisphosphate phosphatase activity IDA 10753883
genes like me logo Genes that share ontologies with INPP5K: view
genes like me logo Genes that share phenotypes with INPP5K: view

Animal Models for INPP5K Gene

MGI Knock Outs for INPP5K:

Animal Model Products

  • Taconic Biosciences Mouse Models for INPP5K

miRNA for INPP5K Gene

miRTarBase miRNAs that target INPP5K

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for INPP5K Gene

Localization for INPP5K Gene

Subcellular locations from UniProtKB/Swiss-Prot for INPP5K Gene

Endoplasmic reticulum. Note=Following stimulation with EGF, translocates to membrane ruffles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for INPP5K Gene COMPARTMENTS Subcellular localization image for INPP5K gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
golgi apparatus 5
nucleus 5
plasma membrane 5
mitochondrion 2

Gene Ontology (GO) - Cellular Components for INPP5K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IDA 12536145
GO:0005634 nucleus IDA 18774950
GO:0005737 cytoplasm ISS --
GO:0005783 endoplasmic reticulum IEA,IDA 12536145
GO:0005802 trans-Golgi network IDA 12556481
genes like me logo Genes that share ontologies with INPP5K: view

Pathways & Interactions for INPP5K Gene

genes like me logo Genes that share pathways with INPP5K: view

Gene Ontology (GO) - Biological Process for INPP5K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0001933 negative regulation of protein phosphorylation ISS --
GO:0005979 regulation of glycogen biosynthetic process ISS --
GO:0006469 negative regulation of protein kinase activity IDA 12556481
GO:0006661 phosphatidylinositol biosynthetic process TAS --
genes like me logo Genes that share ontologies with INPP5K: view

No data available for SIGNOR curated interactions for INPP5K Gene

Drugs & Compounds for INPP5K Gene

(6) Drugs for INPP5K Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
D-Myo-Inositol-1,4-Bisphosphate Experimental Pharma 0

(7) Additional Compounds for INPP5K Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Inositol 1,3,4,5-tetraphosphate
  • 1,3,4,5-Tetrakis(dihydrogen phosphate) myo-Inositol
  • 1D-Myo-inositol 1,3,4,5-tetrakis(dihydrogen phosphate)
  • 1D-Myo-inositol 1,3,4,5-tetrakisphosphate
  • D-Myo-inositol 1,3,4,5-tetrakisphosphate
  • Inositol 1,3,4,5-tetrakis(phosphate)
102850-29-3
Inositol 1,3,4-trisphosphate
  • 1,3,4-Itp
  • 1D-Myo-Inositol 1,3,4-trisphosphate
  • D-Myo-Inositol 1,3,4-trisphosphate
  • I3S
  • Inositol 1,3,4-triphosphate
98102-63-7
Inositol 1,4,5-trisphosphate
  • 1D-Myo-Inositol 1,4,5-trisphosphate
  • D-Myo-Inositol 1,4,5-trisphosphate
  • Inositol 1,4,5-trisphosphate
88269-39-0
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
genes like me logo Genes that share compounds with INPP5K: view

Transcripts for INPP5K Gene

Unigene Clusters for INPP5K Gene

Inositol polyphosphate-5-phosphatase K:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for INPP5K Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^
SP1: -
SP2: - - - - -
SP3: - - - - - -
SP4: - - -
SP5: -
SP6: -
SP7: - - - - -
SP8: - -
SP9: - -
SP10: - - - - -
SP11: - - -
SP12: - - -
SP13: - - - - - - - - - - - - - - - -
SP14: -

ExUns: 12 ^ 13 ^ 14 ^ 15
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for INPP5K Gene

GeneLoc Exon Structure for
INPP5K
ECgene alternative splicing isoforms for
INPP5K

Expression for INPP5K Gene

mRNA expression in normal human tissues for INPP5K Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for INPP5K Gene

This gene is overexpressed in Breast (20.3), Bone (16.0), and Peripheral blood mononuclear cells (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for INPP5K Gene



Protein tissue co-expression partners for INPP5K Gene

NURSA nuclear receptor signaling pathways regulating expression of INPP5K Gene:

INPP5K

SOURCE GeneReport for Unigene cluster for INPP5K Gene:

Hs.632238

mRNA Expression by UniProt/SwissProt for INPP5K Gene:

Q9BT40-INP5K_HUMAN
Tissue specificity: Ubiquitously expressed with highest levels in skeletal muscle, heart and kidney.
genes like me logo Genes that share expression patterns with INPP5K: view

Primer Products

No data available for mRNA differential expression in normal tissues for INPP5K Gene

Orthologs for INPP5K Gene

This gene was present in the common ancestor of animals.

Orthologs for INPP5K Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INPP5K 34 35
  • 99.26 (n)
dog
(Canis familiaris)
Mammalia INPP5K 34 35
  • 85.14 (n)
cow
(Bos Taurus)
Mammalia INPP5K 34 35
  • 84.39 (n)
rat
(Rattus norvegicus)
Mammalia Inpp5k 34
  • 81.36 (n)
mouse
(Mus musculus)
Mammalia Inpp5k 34 16 35
  • 80.58 (n)
oppossum
(Monodelphis domestica)
Mammalia INPP5K 35
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia INPP5K 35
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves INPP5K 34 35
  • 62.4 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 56 (a)
OneToMany
-- 35
  • 55 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia inpp5k 34
  • 60.7 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14338 34
zebrafish
(Danio rerio)
Actinopterygii zgc:162883 34
  • 57.32 (n)
INPP5K (1 of 2) 35
  • 44 (a)
OneToMany
inpp5k 35
  • 40 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6805 35
  • 35 (a)
ManyToMany
CG9784 35
  • 27 (a)
ManyToMany
Species where no ortholog for INPP5K was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for INPP5K Gene

ENSEMBL:
Gene Tree for INPP5K (if available)
TreeFam:
Gene Tree for INPP5K (if available)

Paralogs for INPP5K Gene

Paralogs for INPP5K Gene

genes like me logo Genes that share paralogs with INPP5K: view

Variants for INPP5K Gene

Sequence variations from dbSNP and Humsavar for INPP5K Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_036497 A breast cancer sample
rs1059139 -- 1,494,976(-) AGGAG(C/T)CATTG downstream-variant-500B, utr-variant-3-prime
rs11078471 -- 1,513,164(+) GCAGC(A/G)GCCAG intron-variant
rs1109303 -- 1,500,183(+) TCAAG(G/T)GGCTC intron-variant
rs111236927 -- 1,495,112(+) CCAAC(A/C/G)GAAGC downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for INPP5K Gene

Variant ID Type Subtype PubMed ID
dgv877e212 CNV loss 25503493
esv2715465 CNV deletion 23290073
esv2715466 CNV deletion 23290073
esv3582474 CNV loss 25503493
nsv1057782 CNV gain 25217958
nsv833334 CNV loss 17160897
nsv952098 CNV deletion 24416366

Variation tolerance for INPP5K Gene

Residual Variation Intolerance Score: 71.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.81; 34.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for INPP5K Gene

Human Gene Mutation Database (HGMD)
INPP5K
SNPedia medical, phenotypic, and genealogical associations of SNPs for
INPP5K

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INPP5K Gene

Disorders for INPP5K Gene

Relevant External Links for INPP5K

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
INPP5K

No disorders were found for INPP5K Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for INPP5K Gene

Publications for INPP5K Gene

  1. Identification of a novel domain in two mammalian inositol- polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase SKIP localizes to the endoplasmic reticulum and translocates to membrane ruffles following epidermal growth factor stimulation. (PMID: 12536145) Gurung R. … Mitchell C.A. (J. Biol. Chem. 2003) 2 3 4 22 64
  2. Identification and characterization of a novel inositol polyphosphate 5-phosphatase. (PMID: 10753883) Ijuin T. … Takenawa T. (J. Biol. Chem. 2000) 2 3 4 22 64
  3. Suppression of hepatitis B viral gene expression by phosphoinositide 5-phosphatase SKIP. (PMID: 18774950) Hung C.S. … Ting L.P. (Cell. Microbiol. 2009) 3 22 64
  4. Increased insulin action in SKIP heterozygous knockout mice. (PMID: 18573875) Ijuin T. … Takenawa T. (Mol. Cell. Biol. 2008) 3 22 64
  5. SKIP negatively regulates insulin-induced GLUT4 translocation and membrane ruffle formation. (PMID: 12556481) Ijuin T. … Takenawa T. (Mol. Cell. Biol. 2003) 3 22 64

Products for INPP5K Gene

Sources for INPP5K Gene

Content
Loading form....