Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



INPP5K Gene

protein-coding   GIFtS: 63
GCID: GC17M001397

Inositol Polyphosphate-5-Phosphatase K

  See INPP5K-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Inositol Polyphosphate-5-Phosphatase K1 2     EC 3.1.3.563 8
SKIP2 3 5     Skeletal Muscle And Kidney Enriched Inositol Phosphatase1
Skeletal Muscle And Kidney-Enriched Inositol Phosphatase2 3     Inositol Polyphosphate 5-Phosphatase K2
PPS2 3     EC 3.1.38

External Ids:    HGNC: 338821   Entrez Gene: 517632   Ensembl: ENSG000001323767   OMIM: 6078755   UniProtKB: Q9BT403   

Export aliases for INPP5K gene to outside databases

Previous GC identifer: GC17M001345


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for INPP5K Gene:
This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to
the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the
actin cytoskeleton. Alternatively spliced transcript variants encoding different isoforms have been identified.
(provided by RefSeq, Oct 2008)

GeneCards Summary for INPP5K Gene:
INPP5K (inositol polyphosphate-5-phosphatase K) is a protein-coding gene. Diseases associated with INPP5K include oculocerebrorenal syndrome, and miller-dieker syndrome. GO annotations related to this gene include inositol-1,4,5-trisphosphate 5-phosphatase activity and inositol-polyphosphate 5-phosphatase activity. An important paralog of this gene is INPP5E.

UniProtKB/Swiss-Prot: INP5K_HUMAN, Q9BT40
Function: Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate,
phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has 6-fold higher affinity
for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate. May negatively regulate assembly
of the actin cytoskeleton

Gene Wiki entry for INPP5K (SKIP) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the INPP5K gene promoter:
         HOXA9B   HOXA9   MIF-1   E47   RORalpha2   FOXC1   Meis-1a   Pax-4a   ATF   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidINPP5K promoter sequence
   Search Chromatin IP Primers for INPP5K

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat INPP5K


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.3   Ensembl cytogenetic band:  17p13.3   HGNC cytogenetic band: 17p13.3

INPP5K Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INPP5K gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M001397:  view genomic region     (about GC identifiers)

Start:
1,397,865 bp from pter      End:
1,420,182 bp from pter
Size:
22,318 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: INP5K_HUMAN, Q9BT40 (See protein sequence)
Recommended Name: Inositol polyphosphate 5-phosphatase K  
Size: 448 amino acids; 51090 Da
Secondary accessions: B2R6I2 B2R750 D3DTH8 Q15733 Q9NPJ5 Q9P2R5
Alternative splicing: 2 isoforms:  Q9BT40-1   Q9BT40-2   

Explore the universe of human proteins at neXtProt for INPP5K: NX_Q9BT40

Explore proteomics data for INPP5K at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for INPP5K (Q9BT40)
     WDWIGLY  LWEKDQL  FPPTYKF  KKRKPAWTDRILW 


    See INPP5K Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001129114.1  NP_057616.2  NP_570122.1  

    ENSEMBL proteins: 
     ENSP00000413937   ENSP00000385177   ENSP00000318476   ENSP00000254712   ENSP00000461105  
     ENSP00000413259   ENSP00000459758   ENSP00000466632   ENSP00000461846   ENSP00000458413  
     ENSP00000389334   ENSP00000467376   ENSP00000466929   ENSP00000459029   ENSP00000440147  
     ENSP00000380496  
    Reactome Protein details: Q9BT40

    INPP5K Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for INPP5K
    OriGene Protein Over-expression Lysate for INPP5K
    OriGene MassSpec for INPP5K
    OriGene Custom Protein Services for INPP5K
    GenScript Custom Purified and Recombinant Proteins Services for INPP5K
    Novus Biologicals INPP5K Proteins
    Novus Biologicals INPP5K Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for INPP5K

     
    Search eBioscience for Proteins for INPP5K 

     
    antibodies-online proteins for INPP5K (7 products) 

     
    antibodies-online peptides for INPP5K

    INPP5K Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for INPP5K
    Novus Biologicals INPP5K Antibodies
    Abcam antibodies for INPP5K
    Cloud-Clone Corp. Antibodies for INPP5K
    ThermoFisher Antibody for INPP5K
    antibodies-online antibodies for INPP5K (15 products) 

    INPP5K Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for INPP5K
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for INPP5K
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for INPP5K
    Cloud-Clone Corp. CLIAs for INPP5K
    Search eBioscience for ELISAs for INPP5K 
    antibodies-online kits for INPP5K (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    IUPHAR Guide to PHARMACOLOGY protein family classification: INPP5K
    Inositol polyphosphate phosphatases

    2 InterPro protein domains:
     IPR000300 IPPc
     IPR005135 Endo/exonuclease/phosphatase

    Graphical View of Domain Structure for InterPro Entry Q9BT40

    ProtoNet protein and cluster: Q9BT40

    1 Blocks protein domain: IPB000300 Inositol polyphosphate related phosphatase family

    UniProtKB/Swiss-Prot: INP5K_HUMAN, Q9BT40
    Similarity: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family


    Find genes that share domains with INPP5K           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: INP5K_HUMAN, Q9BT40
    Function: Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate,
    phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has 6-fold higher affinity
    for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate. May negatively regulate assembly
    of the actin cytoskeleton
    Catalytic activity: D-myo-inositol 1,4,5-trisphosphate + H(2)O = myo-inositol 1,4-bisphosphate + phosphate

         Enzyme Numbers (IUBMB): EC 3.1.3.561 2 EC 3.1.32

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004445inositol-polyphosphate 5-phosphatase activity IEA--
    GO:0005000vasopressin receptor activity ISS--
    GO:0005515protein binding IPI16002321
    GO:0016312inositol bisphosphate phosphatase activity IDA10753883
    GO:0034485phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity IDA--
         
    Find genes that share ontologies with INPP5K           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for INPP5K:
     Decreased nuclei size in G2M  Decreased viability 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Inpp5k):
     growth/size/body  homeostasis/metabolism  mortality/aging  muscle 

    Find genes that share phenotypes with INPP5K           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for INPP5K

    miRNA
    Products:
        
    miRTarBase miRNAs that target INPP5K:
    hsa-mir-26b-5p (MIRT029506)

    Block miRNA regulation of human, mouse, rat INPP5K using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate INPP5K (see all 13):
    hsa-miR-455-5p hsa-miR-550a hsa-miR-548d-3p hsa-miR-3675-5p hsa-miR-520a-5p hsa-miR-1227 hsa-miR-221* hsa-miR-4253
    SwitchGear 3'UTR luciferase reporter plasmidINPP5K 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for INPP5K
    Predesigned siRNA for gene silencing in human, mouse, rat INPP5K

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for INPP5K

    Clone
    Products:
         
    OriGene clones in human, mouse for INPP5K (see all 19)
    OriGene ORF clones in mouse, rat for INPP5K
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): INPP5K (NM_130766)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INPP5K
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INPP5K

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for INPP5K
    Browse ESI BIO Cell Lines and PureStem Progenitors for INPP5K 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INPP5K


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    INP5K_HUMAN, Q9BT40: Endoplasmic reticulum. Note=Following stimulation with EGF, translocates to membrane ruffles
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    endoplasmic reticulum5
    nucleus5
    plasma membrane5
    mitochondrion2

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle IDA12536145
    GO:0005634nucleus IDA18774950
    GO:0005737cytoplasm ISS--
    GO:0005783endoplasmic reticulum IDA12536145
    GO:0005802trans-Golgi network IDA12556481

    Find genes that share ontologies with INPP5K           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for INPP5K About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Inositol phosphate metabolism (KEGG)
    Inositol phosphate metabolism0.61
    D-myo-inositol (1,3,4)-trisphosphate biosynthesis0.00
    Phosphatidylinositol signaling system0.61
    D-myo-inositol (1,4,5)-trisphosphate degradation0.00
    superpathway of inositol phosphate compounds0.60
    1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)0.00
    superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism0.00
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38
    3PI Metabolism
    PI Metabolism0.65
    Synthesis of PIPs at the plasma membrane0.65
    4Notch signaling pathway (KEGG)
    Notch Signaling Pathway0.84
    5Glycerophospholipid biosynthesis
    Phospholipid metabolism0.64


    Find genes that share SuperPaths with INPP5K           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected BioSystems Pathways for INPP5K (see all 7)
        Notch Signaling Pathway
    1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)
    D-myo-inositol (1,3,4)-trisphosphate biosynthesis
    D-myo-inositol (1,4,5)-trisphosphate degradation
    3-phosphoinositide degradation

    1 Reactome Pathway for INPP5K
        Synthesis of PIPs at the plasma membrane


    4 Kegg Pathways  (Kegg details for INPP5K):
        Inositol phosphate metabolism
    Metabolic pathways
    Phosphatidylinositol signaling system
    Insulin signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for INPP5K
    Interactions:

        Search GeneGlobe Interaction Network for INPP5K

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for INPP5K (Q9BT401, 2, 3 ENSP000002547124) via UniProtKB, MINT, STRING, and/or I2D (see all 65)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARL6IP1Q150412, 3, ENSP000003067884MINT-67457 I2D: score=5 STRING: ENSP00000306788
    SMN1Q166372, 3MINT-8271234 I2D: score=2 
    SMN2Q166372, 3MINT-8271234 I2D: score=2 
    LNX1Q8TBB11, 3, ENSP000002639254EBI-749162,EBI-739832 I2D: score=1 STRING: ENSP00000263925
    ANXA7P200732, 3MINT-8248472 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 39):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0001933negative regulation of protein phosphorylation ISS--
    GO:0005979regulation of glycogen biosynthetic process ISS--
    GO:0006469negative regulation of protein kinase activity IDA12556481
    GO:0006644phospholipid metabolic process TAS--

    Find genes that share ontologies with INPP5K           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for INPP5K (INP5K)

    6 HMDB Compounds for INPP5K    About this table
    CompoundSynonyms CAS #PubMed Ids
    1D-Myo-inositol 1,4-bisphosphate1D-Myo-inositol 1,4-bisphosphate (see all 5)47055-78-7--
    Inositol 1,3,4,5-tetraphosphate1,3,4,5-tetrakis(dihydrogen phosphate) myo-Inositol (see all 16)102850-29-3--
    Inositol 1,3,4-trisphosphate1,3,4-Itp (see all 8)98102-63-7--
    Inositol 1,4,5-trisphosphate1D-myo-Inositol 1,4,5-trisphosphate (see all 4)88269-39-0--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    6 Novoseek inferred chemical compound relationships for INPP5K gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphatidylinositol-3,4,5-trisphosphate 84.9 3 12536145 (1), 18573875 (1), 12556481 (1)
    inositol 81.6 17 10753883 (2), 16842857 (1), 12536145 (1), 16824732 (1) (see all 8)
    inositol 1,3,4,5-tetrakisphosphate 78.5 1 10753883 (1)
    phosphatidylinositol 46.5 6 10753883 (2), 18573875 (1)
    lipid 34.9 1 16842857 (1)
    glucose 28 5 16842857 (2), 19272022 (1), 12556481 (1)



    Find genes that share compounds with INPP5K           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for INPP5K gene (3 alternative transcripts): 
    NM_001135642.1  NM_016532.3  NM_130766.2  

    Unigene Cluster for INPP5K:

    Inositol polyphosphate-5-phosphatase K
    Hs.632238  [show with all ESTs]
    Unigene Representative Sequence: NM_001135642
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000421807(uc002fsr.3 uc010cjr.3 uc010vql.2 uc010vqm.2 uc010cjs.2)
    ENST00000406424(uc002fss.3 uc002fsq.3) ENST00000320345 ENST00000350761
    ENST00000487039 ENST00000574561 ENST00000461552 ENST00000495339 ENST00000449479
    ENST00000481867 ENST00000477115 ENST00000575172 ENST00000576646 ENST00000573790
    ENST00000460733 ENST00000571274 ENST00000445774 ENST00000477910
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat INPP5K using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate INPP5K (see all 13):
    hsa-miR-455-5p hsa-miR-550a hsa-miR-548d-3p hsa-miR-3675-5p hsa-miR-520a-5p hsa-miR-1227 hsa-miR-221* hsa-miR-4253
    SwitchGear 3'UTR luciferase reporter plasmidINPP5K 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for INPP5K
    Predesigned siRNA for gene silencing in human, mouse, rat INPP5K
    Clone
    Products:
         
    OriGene clones in human, mouse for INPP5K (see all 19)
    OriGene ORF clones in mouse, rat for INPP5K
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): INPP5K (NM_130766)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INPP5K
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INPP5K
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for INPP5K
    OriGene qSTAR qPCR primer pairs in human, mouse for INPP5K
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat INPP5K
      QuantiTect SYBR Green Assays in human, mouse, rat INPP5K
      QuantiFast Probe-based Assays in human, mouse, rat INPP5K

    Additional mRNA sequence: 

    AB036829.1 AB036830.1 AK297955.1 AK303907.1 AK312585.1 AK312844.1 BC004362.1 U45973.1 

    13 DOTS entries:

    DT.95185600  DT.418018  DT.40117980  DT.95185582  DT.92469550  DT.100794853  DT.91826905  DT.95185587 
    DT.100794855  DT.95185585  DT.120983345  DT.100706777  DT.91666722 

    Selected AceView cDNA sequences (see all 280):

    AA847653 BM725656 BM691562 BM665218 AA283094 BU678153 CR590219 AW140051 
    BG477012 BX118438 AI143336 BM669078 BU179138 BM672997 BC004362 BQ011982 
    CD107438 BM704724 BI824023 AA747853 CB153053 AA282930 AL541095 BU175381 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for INPP5K (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^
    SP1:                                                                                                                    -                                       
    SP2:                                                  -     -     -                 -                                   -                                       
    SP3:                                                  -     -     -           -     -                                   -                                       
    SP4:                                                              -                 -                                   -                                       
    SP5:                                                                                                                    -                                       

    ExUns: 12 ^ 13 ^ 14 ^ 15
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for INPP5K

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    INPP5K expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGGCTGTT
    INPP5K Expression
    About this image


    INPP5K expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Epithelial Cells
             Fetal Matrix Cells Hair Follicle
     
     Hair (Integumentary System)
             Fetal Matrix Cells Hair Follicle
    INPP5K Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    INPP5K Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632238

    UniProtKB/Swiss-Prot: INP5K_HUMAN, Q9BT40
    Tissue specificity: Ubiquitously expressed with highest levels in skeletal muscle, heart and kidney

        Custom PCR Arrays for INPP5K
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for INPP5K
    OriGene qSTAR qPCR primer pairs in human, mouse for INPP5K
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat INPP5K
    QuantiTect SYBR Green Assays in human, mouse, rat INPP5K
    QuantiFast Probe-based Assays in human, mouse, rat INPP5K
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INPP5K

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for INPP5K gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Inpp5k1 , 5 inositol polyphosphate 5-phosphatase K1, 5 80.58(n)1
    75.89(a)1
      11 (45.92 cM)5
    190621  NM_008916.21  NP_032942.11 
     756309885 
    chicken
    (Gallus gallus)
    Aves INPP5K1 inositol polyphosphate-5-phosphatase K 62.4(n)
    57.58(a)
      771549  XM_004946527.1  XP_004946584.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    56(a)
    55(a)
    1 ↔ many
    1 ↔ many
    AAWZ02039501(2203-5738)
    AAWZ02039565(1027-4608)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.143382 Xenopus laevis transcribed sequence with weak similarity more 73.09(n)    CF287087.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1628831 zgc:162883 57.32(n)
    48.22(a)
      100037338  NM_001089493.1  NP_001082962.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG68056
    CG97846
    --
    35(a)
    27(a)
    many ↔ many
    many ↔ many
    2R(12892958-12895006)
    X(16490559-16493254)


    ENSEMBL Gene Tree for INPP5K (if available)
    TreeFam Gene Tree for INPP5K (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for INPP5K gene
    INPP5E2  INPPL12  INPP5B2  INPP5J2  SYNJ12  OCRL2  INPP5D2  SYNJ22  
    2 SIMAP similar genes for INPP5K using alignment to 14 protein entries:     INP5K_HUMAN (see all proteins):
    INPP5J    SYNJ1

    Find genes that share paralogs with INPP5K           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for INPP5K (see all 661)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0364974
    A breast cancer sample4--see VAR_0364972 S F mis40--------
    rs1414057611,2
    --1319446(+) CGATTA/GGCGTT 3 -- int1 ut510--------
    rs1470135281,2
    --1319475(+) GGCAAC/GAGACC 3 -- int1 ut510--------
    rs1168972171,2
    C,F--1319566(+) CCTGAT/AGTATG 3 -- int1 ut511Minor allele frequency- A:0.01NA 120
    rs1479768221,2
    --1319584(+) GAAAAA/GTAGGA 3 -- int10--------
    rs1407359911,2
    --1319597(+) AAGATG/TTCTAA 3 -- int10--------
    rs1828536101,2
    --1319874(+) TCCCCA/CCGAGC 3 -- int10--------
    rs1164510021,2
    C,F--1319900(+) GCCAGG/CGTGCC 3 -- int11Minor allele frequency- C:0.09WA 118
    rs2019648531,2
    C,F--1319958(+) ATGGCC/TGCCGT 3 -- ut511Minor allele frequency- T:0.01EU 155
    rs1995192791,2
    --1319983(+) GGTCCG/TGCAGG 3 -- ut510--------

    HapMap Linkage Disequilibrium report for INPP5K (1397865 - 1420182 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for INPP5K:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2715465CNV Deletion23290073
    esv2715466CNV Deletion23290073
    dgv3029n71CNV Loss21882294
    nsv907502CNV Loss21882294
    dgv3028n71CNV Loss21882294
    nsv907504CNV Loss21882294
    nsv833334CNV Loss17160897

    Human Gene Mutation Database (HGMD): INPP5K
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing INPP5K
    DNA2.0 Custom Variant and Variant Library Synthesis for INPP5K

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 607875    OMIM disorders: --

    2 diseases for INPP5K:    
    About MalaCards
    oculocerebrorenal syndrome    miller-dieker syndrome

    1 disease from the University of Copenhagen DISEASES database for INPP5K:
    Oculocerebrorenal syndrome

    Find genes that share disorders with INPP5K           About GenesLikeMe


    Export disorders for INPP5K gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for INPP5K gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with INPP5K)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel domain in two mammalian inositol- polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase SKIP localizes to the endoplasmic reticulum and translocates to membrane ruffles following epidermal growth factor stimulation. (PubMed id 12536145)1, 2, 3, 9 Gurung R.... Mitchell C.A. (J. Biol. Chem. 2003)
    2. Identification and characterization of a novel inositol polyphosphate 5-phosphatase. (PubMed id 10753883)1, 2, 3, 9 Ijuin T.... Takenawa T. (J. Biol. Chem. 2000)
    3. SKIP negatively regulates insulin-induced GLUT4 translocation and membrane ruffle formation. (PubMed id 12556481)1, 9 Ijuin T. and Takenawa T. (Mol. Cell. Biol. 2003)
    4. Suppression of hepatitis B viral gene expression by phosphoinositide 5-phosphatase SKIP. (PubMed id 18774950)1, 9 Hung C.S....Ting L.P. (Cell. Microbiol. 2009)
    5. Increased insulin action in SKIP heterozygous knockout mice. (PubMed id 18573875)1, 9 Ijuin T....Takenawa T. (Mol. Cell. Biol. 2008)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. Role of phosphatidylinositol 3,4,5-trisphosphate (PIP3) 5-phosphatase skeletal muscle- and kidney-enriched inositol polyphosphate phosphatase (SKIP) in myoblast differentiation. (PubMed id 22815484)1 Ijuin T. and Takenawa T. (J. Biol. Chem. 2012)
    8. Regulation of insulin signaling by the phosphatidylinositol 3,4,5-triphosphate phosphatase SKIP through the scaffolding function of Pak1. (PubMed id 22751929)1 Ijuin T. and Takenawa T. (Mol. Cell. Biol. 2012)
    9. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S.... Dorf M.E. (Immunity 2011)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 51763 HGNC: 33882 AceView: SKIP Ensembl:ENSG00000132376 euGenes: HUgn51763
    ECgene: INPP5K Kegg: 51763 H-InvDB: INPP5K

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for INPP5K Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for INPP5K gene:
    Search GeneIP for patents involving INPP5K

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for INPP5K  
     OriGene qPCR primer pairs and template standards for INPP5K   OriGene Protein Over-expression Lysate for INPP5K  
     OriGene MassSpec for INPP5K   OriGene clones in human, mouse for INPP5K  
     OriGene qSTAR qPCR primer pairs in human, mouse for INPP5K   OriGene Purified Protein for INPP5K  
     OriGene ORF clones in mouse, rat for INPP5K   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for INPP5K   OriGene Custom Protein Services for INPP5K  

     
     
     Block miRNA regulation of human, mouse, rat INPP5K using miScript Target Protectors SeqTarget long-range PCR primers for resequencing INPP5K
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat INPP5K Predesigned siRNA for gene silencing in human, mouse, rat INPP5K
     QuantiFast Probe-based Assays in human, mouse, rat INPP5K QuantiTect SYBR Green Assays in human, mouse, rat INPP5K
     Custom PCR Arrays for INPP5K Search Chromatin IP Primers for INPP5K
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat INPP5K  Search GeneGlobe Interaction Network for INPP5K
     Regulatory tfbs in INPP5K promoter
     GenScript Custom Purified and Recombinant Proteins Services for INPP5K GenScript cDNA clones with any tag delivered in your preferred vector for INPP5K
     GenScript Custom Assay Services for INPP5K GenScript Custom overexpressing Cell Line Services for INPP5K
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for INPP5K (INP5K)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     INPP5K antibodies
     INPP5K proteins
     INPP5K lysates
     Antibodies for INPP5K
     See all of Abcam's Antibodies, Kits and Proteins for INPP5K
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for INPP5K
     Antibodies for INPP5K
     ELISAs for INPP5K
     CLIAs for INPP5K



     Browse ESI BIO Cell Lines and PureStem Progenitors for INPP5K
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INPP5K
     SwitchGear 3'UTR luciferase reporter plasmids for INPP5K
     SwitchGear Promoter luciferase reporter plasmids for INPP5K
     ThermoFisher Antibody for INPP5K
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INPP5K
     Browse compounds at ApexBio
     Search Addgene for plasmids for INPP5K
      Search eBioscience for proteins for INPP5K
      Search eBioscience for elisas for INPP5K
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for INPP5K
     antibodies-online antibodies for INPP5K (15 products)
     antibodies-online kits for INPP5K (4 products)
     antibodies-online peptides for INPP5K
     antibodies-online proteins for INPP5K (7 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      INPP5K gene at Home site.
    Version: 3.12.252 27 Nov 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4