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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

INPP5J Gene

protein-coding GIFtS: 56
GCID: GC22P031518

inositol polyphosphate-5-phosphatase J

(Previous names: phosphatidylinositol (4,5) bisphosphate 5-phosphatase,...)
(Previous symbol: PIB5PA)

Explore 7 diseases affiliated with
INPP5J via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Inositol Polyphosphate-5-Phosphatase J¹ ²		Inositol Polyphosphate 5-Phosphatase J² ³
PIB5PA¹ ² ³ ⁵		EC 3.1.3.56³ ⁸
PIPP² ³ ⁵		Phosphatidylinositol 4,5-Bisphosphate 5-Phosphatase A²
INPP5¹ ²		EC 3.1.3⁸
Phosphatidylinositol (4,5) Bisphosphate 5-Phosphatase, A¹ ²

External Ids:	HGNC: 8956¹	Entrez Gene: 27124²	Ensembl: ENSG00000185133⁷	OMIM: 606481⁵	UniProtKB: Q15735³

Export aliases for INPP5J gene to outside databases

Previous GC identifers: GC22P029848 GC22P014480

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: PI5PA_HUMAN, Q15735

Function: Inositol 5-phosphatase, which converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate. Also

converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate and inositol

1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function of

inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles (By similarity)

Gene Wiki entry for INPP5J (PIB5PA)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000022.10 NC_018933.1 NT_011520.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the INPP5J gene promoter:
Pax-5 Nkx2-5 Tal-1beta E47 GATA-1 c-Myb FOXO1a FOXO1 ATF6
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: INPP5J promoter sequence

Search SABiosciences Chromatin IP Primers for INPP5J

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INPP5J

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.2 Ensembl cytogenetic band: 22q12.2 HGNC cytogenetic band: 22q12.2

INPP5J Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INPP5J gene location

GeneLoc information about chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22P031518: view genomic region (about GC identifiers)

Start:	31,518,717 bp from pter	End:	31,530,683 bp from pter
Size:	11,967 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PI5PA_HUMAN, Q15735 (See protein sequence)

Recommended Name: Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A

Size: 1006 amino acids; 107197 Da

Subcellular location: Cytoplasm (By similarity). Note=Predominantly localized to membrane ruffles (By similarity)

Sequence caution: Sequence=AAD15618.1; Type=Erroneous gene model prediction;

Secondary accessions: B3KS54 Q32M61 Q6ZTH6 Q8N902 Q9UDT9

Alternative splicing: 3 isoforms: Q15735-1 Q15735-2 Q15735-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for INPP5J: NX_Q15735

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q15735

4/5 DME Specific Peptides for INPP5J (Q15735) (see all 5)

DYVAYVW

WDWIGLY

AIGLQEV

LWEKDQL

INPP5J Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001002837.1

ENSEMBL proteins:

ENSP00000401124 ENSP00000333262 ENSP00000406570 ENSP00000383150 ENSP00000384596

ENSP00000384534 ENSP00000385264 ENSP00000385343 ENSP00000384540 ENSP00000392924

Reactome Protein details: Q15735
Human Recombinant Protein Products for INPP5J:

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	Uscn Proteins for INPP5J

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001726	ruffle	IDA	12536145
GO:0005737	cytoplasm	IDA	12536145
GO:0005829	cytosol	TAS	--
GO:0005886	plasma membrane	IEA	--
GO:0030426	growth cone	IEA	--

INPP5J for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

INPP5J for domains About GeneDecksing

2 InterPro domains/families:

IPR005135 Endo/exonuclease/phosphatase

IPR000300 IPPc

Graphical View of Domain Structure for InterPro Entry Q15735

ProtoNet protein and cluster: Q15735

1 Blocks protein family: IPB000300 Inositol polyphosphate related phosphatase family

UniProtKB/Swiss-Prot: PI5PA_HUMAN, Q15735

Domain: The 5 Arg-Ser-Xaa-Ser-Xaa-Xaa (RSXSXX) motifs may constitute binding sites for the 14-3-3 protein

Similarity: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: PI5PA_HUMAN, Q15735

Function: Inositol 5-phosphatase, which converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate. Also

converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate and inositol

1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function of

inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles (By similarity)

Catalytic activity: D-myo-inositol 1,4,5-trisphosphate + H(2)O = myo-inositol 1,4-bisphosphate + phosphate

Catalytic activity: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H(2)O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate

Enzyme Numbers (IUBMB): EC 3.1.3.56¹ ² EC 3.1.3²

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004445	inositol-polyphosphate 5-phosphatase activity	IEA	--
GO:0017124	SH3 domain binding	IEA	--
GO:0034485	phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity	IEA	--
GO:0052658	inositol-1,4,5-trisphosphate 5-phosphatase activity	IEA	--
GO:0052659	inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity	IEA	--

INPP5J for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for INPP5J:

Decreased focal adhesion (FA)

Increased apoptosis

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for INPP5J

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INPP5J

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

D-myo-inositol (1,3,4)-trisphosphate biosynthesis

D-myo-inositol (1,3,4)-trisphosphate biosynthesis	1.00	D-myo-inositol (1,4,5)-trisphosphate degradation	0.40
1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)	0.76	3-phosphoinositide degradation	0.33
superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism	0.75	Synthesis of IP2, IP, and Ins in the cytosol	0.24

Metabolism

	Metabolism	1.00			Metabolism of lipids and lipoproteins	0.34
	Metabolic pathways	0.38

Inositol phosphate metabolism

	Inositol phosphate metabolism	1.00			Phosphatidylinositol signaling system	0.59
	superpathway of inositol phosphate compounds	0.59

PI Metabolism

PI Metabolism

1.00

Synthesis of PIPs at the plasma membrane

0.66

Synthesis of IP3 and IP4 in the cytosol

Synthesis of IP3 and IP4 in the cytosol

1.00

Inositol phosphate metabolism

0.57

Pathway sources
See GeneCards unified pathways
Show all pathways

5/6 BioSystems Pathways for INPP5J (see all 6)

	D-myo-inositol (1,3,4)-trisphosphate biosynthesis
	D-myo-inositol (1,4,5)-trisphosphate degradation
	1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)
	superpathway of inositol phosphate compounds
	superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism

5/8 Reactome Pathways for INPP5J (see all 8)

	Synthesis of IP2, IP, and Ins in the cytosol
	Metabolism
	Phospholipid metabolism
	Inositol phosphate metabolism
	Synthesis of IP3 and IP4 in the cytosol

3 Kegg Pathways (Kegg details for INPP5J):

	Inositol phosphate metabolism
	Metabolic pathways
	Phosphatidylinositol signaling system

INPP5J for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for INPP5J

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/30 Interacting proteins for INPP5J (ENSP00000384534⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 30)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
INPP1	ENSP00000325423⁴	STRING: ENSP00000325423
INPP4A	ENSP00000074304⁴	STRING: ENSP00000074304
ITPK1	ENSP00000267615⁴	STRING: ENSP00000267615
ITPKA	ENSP00000260386⁴	STRING: ENSP00000260386
PTEN	ENSP00000361021⁴	STRING: ENSP00000361021

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006644	phospholipid metabolic process	TAS	--
GO:0006661	phosphatidylinositol biosynthetic process	TAS	--
GO:0010977	negative regulation of neuron projection development	IEA	--
GO:0031115	negative regulation of microtubule polymerization	IEA	--
GO:0033137	negative regulation of peptidyl-serine phosphorylation	IEA	--

INPP5J for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

INPP5J for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for INPP5J

6 HMDB Compounds for INPP5J About this table

Compound	Synonyms	CAS #	PubMed Ids
1D-Myo-inositol 1,4-bisphosphate	1D-Myo-inositol 1,4-bisphosphate (see all 5)	47055-78-7	--
Inositol 1,3,4,5-tetraphosphate	1,3,4,5-tetrakis(dihydrogen phosphate) myo-Inositol (see all 16)	102850-29-3	--
Inositol 1,3,4-trisphosphate	1,3,4-Itp (see all 8)	98102-63-7	--
Inositol 1,4,5-trisphosphate	1D-myo-Inositol 1,4,5-trisphosphate (see all 4)	88269-39-0	--
Phosphate	NFB Orthophosphate (see all 13)	14265-44-2	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--

1 DrugBank Compound for INPP5J About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Heme	--	--	target	--	10592235

10 Novoseek chemical compound relationships for INPP5J gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
inositol 1,3,4,5-tetrakisphosphate	90	8	9430698 (1), 9525932 (1), 7556092 (1), 8529643 (1) (see all 8)
phosphatidylinositol-3,4,5-trisphosphate	86.4	3	9430698 (1), 7556092 (1), 12556481 (1)
inositol	81.8	20	1321346 (2), 11691828 (1), 15093605 (1), 9038219 (1) (see all 14)
phosphoinositide	73.1	12	12018403 (2), 7556092 (1), 8968499 (1), 19272022 (1) (see all 9)
inositol 1,4,5 trisphosphate	69.8	7	9430698 (1), 9525932 (1), 7556092 (1), 8529643 (1) (see all 7)
phosphatidylinositol	69.2	6	9525932 (1), 19736566 (1), 12676785 (1), 8256286 (1) (see all 6)
phosphatidylinositol 3-phosphate	58.9	2	16880518 (2)
tyrosine	32	5	8805618 (1), 9838104 (1), 9009077 (1), 9232445 (1)
calcium	7.34	4	8529643 (1), 9973602 (1), 1718960 (1)
lipid	6.41	1	12018403 (1)

Search CenterWatch for drugs/clinical trials and news about INPP5J / PI5PA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for INPP5J gene (2 alternative transcripts):

NM_014422.2 NM_001002837.1

Unigene Cluster for INPP5J:

Inositol polyphosphate-5-phosphatase J

Hs.517549 [show with all ESTs]

Unigene Representative Sequence: AK308921

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000463528 ENST00000412985 ENST00000331075(uc003ajt.4 uc003ajs.4 uc011alk.2 uc003aju.4 uc010gwg.3)

ENST00000461241(uc003ajw.3) ENST00000420017 ENST00000400294 ENST00000405300(uc003ajv.4)

ENST00000404390 ENST00000402238 ENST00000404453 ENST00000401755 ENST00000412277(uc010gwf.3)

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Additional cDNA sequence:

AK126610.1 AK308921.1 AK309548.1 U45975.1

11 DOTS entries:

DT.311553 DT.100024052 DT.100777877 DT.100753623 DT.100777879 DT.100806091 DT.101982761 DT.100687939

DT.100832177 DT.100778863 DT.120648431

24/106 AceView cDNA sequences (see all 106):

CR617561 CR611668 CA868401 CR617784 BP352955 BU507439 BM711841 AI540418

AK126610 CR610046 CR615040 CR625511 CR624482 BF436472 CB107367 CR604969

CR615918 BU584792 BM994866 BU684668 CR599279 BX102670 BC041652 NM_001002837

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for INPP5J (see all 10) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	·	2d	·	2e	·	2f	^	3	^	4	^	5a	·	5b	^	6	^	7a	·	7b	^	8	^	9a	·	9b	·	9c	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17a	·
SP1:															-										-										-
SP2:															-		-								-										-
SP3:															-		-						-		-										-
SP4:
SP5:															-		-		-		-				-

ExUns:	17b
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for INPP5J

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

INPP5J expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGACTTCAT

About this image

INPP5J expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Antral Follicle

Cumulus Cells

Ovary

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor T42 (Embryonic Progenitor Cell)

See INPP5J Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for INPP5J

SOURCE GeneReport for Unigene cluster: Hs.517549

SABiosciences Custom PCR Arrays for INPP5J

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for INPP5J gene from 7/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	INPP5J¹	inositol polyphosphate-5-phosphatase J	73.13(n) 74.46(a)		416996 XM_415287.3 XP_415287.3
lizard (Anolis carolinensis)	Reptilia	INPP5J⁶	--	70(a)	1 ↔ 1	GL343417.1(389773-395842)
zebrafish (Danio rerio)	Actinopterygii	LOC569568¹	phosphatidylinositol 4,5-bisphosphate 5-phosphatase more	60.15(n) 58.67(a)		569568 XM_692965.4 XP_698057.4
fruit fly (Drosophila melanogaster)	Insecta	CG9784¹	CG9784	51.75(n) 37.85(a)		32629 NM_132907.1 NP_573135.1
worm (Caenorhabditis elegans)	Secernentea	T25B9.10⁶	--	17(a)	1 → many	IV(10770219-10773360)
thale cress (Arabidopsis thaliana)	eudicotyledons	5PTASE11¹	Type I inositol-1,4,5-trisphosphate 5-phosphatase 11	44.44(n) 36.7(a)		841160 NM_103644.2 NP_175182.2
rice (Oryza sativa)	Liliopsida	-- -- (see all 3)	endonuclease/exonuclease/phosphatase family domain... endonuclease/exonuclease/phosphatase family domain... (see all 3)	9(a) 8(a) (see all 3)	possible ortholog possible ortholog (see all 3)	9(19363497-19368463) 8(26059752-26067127)

ENSEMBL Gene Tree for INPP5J (if available)
TreeFam Gene Tree for INPP5J (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for INPP5J gene

INPP5B² SYNJ1² INPP5D² OCRL² INPP5K² INPP5E² INPPL1² SYNJ2²

2 SIMAP similar genes for INPP5J using alignment to 6 protein entries: PI5PA_HUMAN (see all proteins):

INPP5K SYNJ1

INPP5J for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs184825615^1,2		--	31516973(+)	`GATTGA/CATGAA`	1	--	us2k¹		0	--	--	--	--
rs11703158^1,2	C,H	--	31517035(+)	`tctttC/Tttttt`	1	--	us2k¹ trp³		0	--	--	--	--
rs62236159^1,2		--	31517057(+)	`TGAGAA/CAGGGC`	1	--	us2k¹		0	--	--	--	--
rs189594986^1,2		--	31517097(+)	`TGGTAC/TGATCT`	1	--	us2k¹		0	--	--	--	--
rs145669135^1,2		--	31517181(+)	`GACTAC/GAGGCA`	1	--	us2k¹		0	--	--	--	--
rs117692903^1,2	F	--	31517201(+)	`ACACCC/TGGCTC`	1	--	us2k¹		1		NA	120
rs147552669^1,2		--	31517316(+)	`GATTAC/TCCGCA`	1	--	us2k¹		0	--	--	--	--
rs141980004^1,2		--	31517328(+)	`TTTGCC/TAGTAC`	1	--	us2k¹		0	--	--	--	--
rs145795979^1,2		--	31517344(+)	`CAGCCC/TGGGGG`	1	--	us2k¹		0	--	--	--	--
rs193087498^1,2		--	31517345(+)	`AGCCCA/GGGGGC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for INPP5J (31518717 - 31530683 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for INPP5J: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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INPP5J for disorders           About GeneDecksing

OMIM gene information: 606481    OMIM disorders: --

7 diseases for INPP5J:    About MalaCards

guillain-barre syndrome developmental disabilities oculocerebrorenal syndrome glanders

lymphoproliferative syndrome breast cancer neuronitis

3 Novoseek disease relationships for INPP5J gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lowe syndrome	95	6	9430698 (1), 15353600 (1), 1321346 (1), 7762303 (1) (see all 5)
developmental disabilities	25	1	7762303 (1)
genetic disorder	11	1	9599410 (1)

Export disorders for INPP5J gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for INPP5J gene, integrated from 9 sources (see all 79):
(articles sorted by number of sources associating them with INPP5J)

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The DNA sequence of human chromosome 22. (PubMed id 10591208)^{1, 2, 3} Dunham I....O'Brien K.P. (1999)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Identification of a novel domain in two mammalian inositol- polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase SKIP localizes to the endoplasmic reticulum and translocates to membrane ruffles following epidermal growth factor stimulation. (PubMed id 12536145)^{1, 9} Gurung R.... Mitchell C.A. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
The Protein Data Bank. (PubMed id 10592235)⁷ Berman H.M....Bourne P.E. (2000)
Novel inositol polyphosphate 5-phosphatase localizes at membrane ruffles. (PubMed id 10593988)¹ Mochizuki Y. and Takenawa T. (1999)
A novel isoform of the smooth muscle cell differentiation marker smoothelin. (PubMed id 10023782)¹ Kraemer J.... Leonhardt H. (1999)
Toward a complete human genome sequence. (PubMed id 9847074)¹ Wilson R. (1998)
The inositol polyphosphate 5-phosphatase, PIPP, Is a novel regulator of phosphoinositide 3-kinase-dependent neurite elongation. (PubMed id 16280363)⁹ Ooms L.M....Mitchell C.A. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 27124	HGNC: 8956	AceView: PIB5PA	Ensembl:ENSG00000185133	euGenes: HUgn27124
ECgene: INPP5J	Kegg: 27124	H-InvDB: INPP5J

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for INPP5J	Pharmacogenomics, SNPs, Pathways

Intellectual Property for INPP5J gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for INPP5J gene:
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INPP5J Gene

inositol polyphosphate-5-phosphatase J

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INPP5J Gene

inositol polyphosphate-5-phosphatase J

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