Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

INPP5J Gene

protein-coding   GIFtS: 62
GCID: GC22P031518

Inositol Polyphosphate-5-Phosphatase J

(Previous names: phosphatidylinositol (4,5) bisphosphate 5-phosphatase, A)
(Previous symbol: PIB5PA)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Inositol Polyphosphate-5-Phosphatase J1 2     EC 3.1.3.563 8
PIB5PA1 2 3 5     INPP52
PIPP2 3 5     Phosphatidylinositol 4,5-Bisphosphate 5-Phosphatase A2
Phosphatidylinositol (4,5) Bisphosphate 5-Phosphatase, A1 2     EC 3.1.38
Inositol Polyphosphate 5-Phosphatase J2 3     

External Ids:    HGNC: 89561   Entrez Gene: 271242   Ensembl: ENSG000001851337   OMIM: 6064815   UniProtKB: Q157353   

Export aliases for INPP5J gene to outside databases

Previous GC identifers: GC22P029848 GC22P014480


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for INPP5J Gene: 
INPP5J (inositol polyphosphate-5-phosphatase J) is a protein-coding gene. Diseases associated with INPP5J include oculocerebrorenal syndrome, and glanders, and among its related super-pathways are D-myo-inositol (1,3,4)-trisphosphate biosynthesis and Phosphatidylinositol signaling system. GO annotations related to this gene include SH3 domain binding and inositol-1,4,5-trisphosphate 5-phosphatase activity. An important paralog of this gene is INPP5B.

UniProtKB/Swiss-Prot: PI5PA_HUMAN, Q15735
Function: Inositol 5-phosphatase, which converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate. Also
converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate and inositol
1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function
of inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles (By
similarity)

Gene Wiki entry for INPP5J (PIB5PA) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NT_011520.12  NC_018933.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the INPP5J gene promoter:
         Pax-5   Nkx2-5   Tal-1beta   E47   GATA-1   c-Myb   FOXO1a   FOXO1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidINPP5J promoter sequence
   Search SABiosciences Chromatin IP Primers for INPP5J

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INPP5J


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.2   Ensembl cytogenetic band:  22q12.2   HGNC cytogenetic band: 22q12.2

INPP5J Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INPP5J gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P031518:  view genomic region     (about GC identifiers)

Start:
31,518,717 bp from pter      End:
31,530,683 bp from pter
Size:
11,967 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PI5PA_HUMAN, Q15735 (See protein sequence)
Recommended Name: Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A  
Size: 1006 amino acids; 107197 Da
Subcellular location: Cytoplasm (By similarity). Note=Predominantly localized to membrane ruffles (By similarity)
Sequence caution: Sequence=AAD15618.1; Type=Erroneous gene model prediction;
Secondary accessions: B3KS54 Q32M61 Q6ZTH6 Q8N902 Q9UDT9
Alternative splicing: 3 isoforms:  Q15735-1   Q15735-2   Q15735-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for INPP5J: NX_Q15735

Explore proteomics data for INPP5J at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15735

  • 4/5 DME Specific Peptides for INPP5J (Q15735) (see all 5)
     DYVAYVW  WDWIGLY  AIGLQEV  LWEKDQL 

    INPP5J Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    INPP5J Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001002837.1  NP_001271214.1  NP_001271215.1  NP_001271216.1  NP_001271217.1  NP_001271218.1  

    ENSEMBL proteins: 
     ENSP00000401124   ENSP00000333262   ENSP00000406570   ENSP00000383150   ENSP00000384596  
     ENSP00000384534   ENSP00000385264   ENSP00000385343   ENSP00000384540   ENSP00000392924  
    Reactome Protein details: Q15735
    Human Recombinant Protein Products for INPP5J: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for INPP5J
    OriGene Protein Over-expression Lysate for INPP5J
    OriGene MassSpec for INPP5J 
    OriGene Custom Protein Services for INPP5J
    GenScript Custom Purified and Recombinant Proteins Services for INPP5J
    Novus Biologicals INPP5J Protein
    Novus Biologicals INPP5J Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for INPP5J 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle IDA12536145
    GO:0005737cytoplasm IDA12536145
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IEA--
    GO:0030426growth cone IEA--

    INPP5J for ontologies           About GeneDecksing



    INPP5J Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for INPP5J
    GenScript Custom Superior Antibodies Services for INPP5J
    Novus Biologicals INPP5J Antibodies
    Abcam antibodies for INPP5J
    Cloud-Clone Corp. Antibodies for INPP5J 
    ThermoFisher Antibodies for INPP5J
    LSBio Antibodies in human, mouse, rat for INPP5J 

    Assay Products for INPP5J: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for INPP5J
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for INPP5J
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for INPP5J 
    Cloud-Clone Corp. CLIAs for INPP5J


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: INPP5J 
    Inositol polyphosphate phosphatases

    2 InterPro protein domains:
     IPR000300 IPPc
     IPR005135 Endo/exonuclease/phosphatase

    Graphical View of Domain Structure for InterPro Entry Q15735

    ProtoNet protein and cluster: Q15735

    1 Blocks protein domain: IPB000300 Inositol polyphosphate related phosphatase family

    UniProtKB/Swiss-Prot: PI5PA_HUMAN, Q15735
    Domain: The 5 Arg-Ser-Xaa-Ser-Xaa-Xaa (RSXSXX) motifs may constitute binding sites for the 14-3-3 protein
    Similarity: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family


    INPP5J for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PI5PA_HUMAN, Q15735
    Function: Inositol 5-phosphatase, which converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate. Also
    converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate and inositol
    1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function
    of inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles (By
    similarity)
    Catalytic activity: D-myo-inositol 1,4,5-trisphosphate + H(2)O = myo-inositol 1,4-bisphosphate + phosphate
    Catalytic activity: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H(2)O = 1D-myo-inositol 1,3,4-trisphosphate +
    phosphate

         Enzyme Numbers (IUBMB): EC 3.1.3.561 2 EC 3.1.32

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004445inositol-polyphosphate 5-phosphatase activity IEA--
    GO:0017124SH3 domain binding IEA--
    GO:0034485phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity IEA--
    GO:0052658inositol-1,4,5-trisphosphate 5-phosphatase activity IEA--
    GO:0052659inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity IEA--
         
    INPP5J for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for INPP5J:
     Decreased focal adhesion (FA)   Increased apoptosis 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for INPP5J 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for INPP5J

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for INPP5J 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for INPP5J 

    miRNA
    Products:
        
    miRTarBase miRNAs that target INPP5J:
    hsa-mir-346 (MIRT004238)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat INPP5J
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate INPP5J:
    hsa-miR-27a hsa-miR-219-5p hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmidINPP5J 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for INPP5J
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat INPP5J

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for INPP5J
    Sirion Biotech Customized adenovirus for overexpression of INPP5J

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for INPP5J (see all 8)
    OriGene ORF clones in mouse, rat for INPP5J
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: INPP5J (NM_001002837)
    Sino Biological Human cDNA Clone for INPP5J
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INPP5J
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INPP5J
    Sirion Biotech Customized lentivirus for stable overexpression of INPP5J 
                         Customized lentivirus expression plasmids for stable overexpression of INPP5J 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for INPP5J
    Search LifeMap BioReagents cell lines for INPP5J
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INPP5J


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for INPP5J About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1D-myo-inositol (1,3,4)-trisphosphate biosynthesis
    D-myo-inositol (1,3,4)-trisphosphate biosynthesis0.76
    D-myo-inositol (1,4,5)-trisphosphate degradation0.65
    1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)0.76
    Synthesis of IP2, IP, and Ins in the cytosol0.50
    superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism0.75
    3-phosphoinositide degradation0.33
    2Inositol phosphate metabolism
    Inositol phosphate metabolism0.61
    superpathway of inositol phosphate compounds0.60
    Phosphatidylinositol signaling system0.61
    3Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    Metabolic pathways0.40
    4PI Metabolism
    PI Metabolism0.66
    Synthesis of PIPs at the plasma membrane0.66
    5Synthesis of IP3 and IP4 in the cytosol
    Inositol phosphate metabolism0.57
    Synthesis of IP3 and IP4 in the cytosol0.57

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/6 BioSystems Pathways for INPP5J (see all 6)
        D-myo-inositol (1,4,5)-trisphosphate degradation
    1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)
    D-myo-inositol (1,3,4)-trisphosphate biosynthesis
    superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism
    3-phosphoinositide degradation


    5/8        Reactome Pathways for INPP5J (see all 8)
        Synthesis of IP2, IP, and Ins in the cytosol
    Metabolism
    Phospholipid metabolism
    Inositol phosphate metabolism
    Synthesis of IP3 and IP4 in the cytosol


    3         Kegg Pathways  (Kegg details for INPP5J):
        Inositol phosphate metabolism
    Metabolic pathways
    Phosphatidylinositol signaling system


    INPP5J for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for INPP5J

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/30 Interacting proteins for INPP5J (ENSP000003845344) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    INPP1ENSP000003254234STRING: ENSP00000325423
    INPP4AENSP000000743044STRING: ENSP00000074304
    ITPK1ENSP000002676154STRING: ENSP00000267615
    ITPKAENSP000002603864STRING: ENSP00000260386
    PTENENSP000003610214STRING: ENSP00000361021
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006644phospholipid metabolic process TAS--
    GO:0006661phosphatidylinositol biosynthetic process TAS--
    GO:0010977negative regulation of neuron projection development IEA--
    GO:0031115negative regulation of microtubule polymerization IEA--
    GO:0033137negative regulation of peptidyl-serine phosphorylation IEA--

    INPP5J for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    INPP5J for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for INPP5J (PI5PA)

    6 HMDB Compounds for INPP5J    About this table
    CompoundSynonyms CAS #PubMed Ids
    1D-Myo-inositol 1,4-bisphosphate1D-Myo-inositol 1,4-bisphosphate (see all 5)47055-78-7--
    Inositol 1,3,4,5-tetraphosphate1,3,4,5-tetrakis(dihydrogen phosphate) myo-Inositol (see all 16)102850-29-3--
    Inositol 1,3,4-trisphosphate1,3,4-Itp (see all 8)98102-63-7--
    Inositol 1,4,5-trisphosphate1D-myo-Inositol 1,4,5-trisphosphate (see all 4)88269-39-0--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    1 DrugBank Compound for INPP5J    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Heme-- --target--10592235

    10 Novoseek inferred chemical compound relationships for INPP5J gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inositol 1,3,4,5-tetrakisphosphate 90 8 9430698 (1), 9525932 (1), 7556092 (1), 8529643 (1) (see all 8)
    phosphatidylinositol-3,4,5-trisphosphate 86.4 3 9430698 (1), 7556092 (1), 12556481 (1)
    inositol 81.8 20 1321346 (2), 11691828 (1), 15093605 (1), 9038219 (1) (see all 14)
    phosphoinositide 73.1 12 12018403 (2), 7556092 (1), 8968499 (1), 19272022 (1) (see all 9)
    inositol 1,4,5 trisphosphate 69.8 7 9430698 (1), 9525932 (1), 7556092 (1), 8529643 (1) (see all 7)
    phosphatidylinositol 69.2 6 9525932 (1), 19736566 (1), 12676785 (1), 8256286 (1) (see all 6)
    phosphatidylinositol 3-phosphate 58.9 2 16880518 (2)
    tyrosine 32 5 8805618 (1), 9838104 (1), 9009077 (1), 9232445 (1)
    calcium 7.34 4 8529643 (1), 9973602 (1), 1718960 (1)
    lipid 6.41 1 12018403 (1)

    Search CenterWatch for drugs/clinical trials and news about INPP5J / PI5PA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for INPP5J gene (7 alternative transcripts): 
    NM_014422.2  NM_001002837.2  NM_001284285.1  NM_001284286.1  NM_001284287.1  NM_001284288.1  NM_001284289.1  

    Unigene Cluster for INPP5J:

    Inositol polyphosphate-5-phosphatase J
    Hs.517549  [show with all ESTs]
    Unigene Representative Sequence: AK308921
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000463528 ENST00000412985 ENST00000331075(uc003ajt.4 uc003ajs.4 uc011alk.2 uc003aju.4 uc010gwg.3)
    ENST00000461241(uc003ajw.3) ENST00000420017 ENST00000400294 ENST00000405300(uc003ajv.4)
    ENST00000404390 ENST00000402238 ENST00000404453 ENST00000401755 ENST00000412277(uc010gwf.3)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat INPP5J
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate INPP5J:
    hsa-miR-27a hsa-miR-219-5p hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmidINPP5J 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for INPP5J
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat INPP5J
    Clone
    Products:
         
    OriGene clones in human, mouse for INPP5J (see all 8)
    OriGene ORF clones in mouse, rat for INPP5J
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: INPP5J (NM_001002837)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INPP5J
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INPP5J
    Sirion Biotech Customized lentivirus for stable overexpression of INPP5J 
                         Customized lentivirus expression plasmids for stable overexpression of INPP5J 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for INPP5J
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat INPP5J
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INPP5J
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INPP5J

    Additional mRNA sequence: 

    AK126610.1 AK308921.1 AK309548.1 U45975.1 

    11 DOTS entries:

    DT.311553  DT.100024052  DT.100777877  DT.100753623  DT.100777879  DT.100806091  DT.101982761  DT.100687939 
    DT.100832177  DT.100778863  DT.120648431 

    24/106 AceView cDNA sequences (see all 106):

    BU584792 BX102670 CR604969 CB107367 BF436472 AK126610 BM711841 CR615040 
    BP352955 CR615918 CR624482 BU507439 BU684668 CR617784 BC041652 CR611668 
    CR610046 CR625511 BM994866 CR599279 AI540418 CA868401 CR617561 NM_001002837 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for INPP5J (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a ·
    SP1:                                            -                             -                             -                                                   
    SP2:                                            -     -                       -                             -                                                   
    SP3:                                            -     -                 -     -                             -                                                   
    SP4:                                                                                                                                                            
    SP5:                                            -     -     -     -           -                                                                                 

    ExUns: 17b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for INPP5J

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    INPP5J expression in normal human tissues (normalized intensities)      INPP5J embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGACTTCAT
    INPP5J Expression
    About this image


    INPP5J expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/14 selected tissues (see all 14) fully expand
     
     Brain (Nervous System)    fully expand to see all 14 entries
             Thalamus
             Septum   
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Membranous Facial Bones
             skeleton/cranium   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Neural Crest (Gastrulation Derivatives)
             skeleton/cranium   

    See INPP5J Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for INPP5J

    SOURCE GeneReport for Unigene cluster: Hs.517549
        SABiosciences Custom PCR Arrays for INPP5J
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for INPP5J
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat INPP5J
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INPP5J
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INPP5J
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INPP5J

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for INPP5J gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Inpp5j1 , 5 inositol polyphosphate 5-phosphatase J1, 5 82.88(n)1
    89.41(a)1
      11 (2.45 cM)5
    1708351  NM_172439.31  NP_766027.21 
     34943755 
    chicken
    (Gallus gallus)
    Aves INPP5J1 inositol polyphosphate-5-phosphatase J 73.13(n)
    74.46(a)
      416996  XM_415287.3  XP_415287.3 
    lizard
    (Anolis carolinensis)
    Reptilia INPP5J6
    Uncharacterized protein
    56(a)
    1 ↔ 1
    GL343417.1(384204-396845)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5695681 phosphatidylinositol 4,5-bisphosphate 5-phosphatase more 60.15(n)
    58.67(a)
      569568  XM_692965.4  XP_698057.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG97841 CG9784 51.75(n)
    37.85(a)
      32629  NM_132907.1  NP_573135.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons 5PTASE111 Type I inositol-1,4,5-trisphosphate 5-phosphatase 11 44.44(n)
    36.7(a)
      841160  NM_103644.2  NP_175182.2 


    ENSEMBL Gene Tree for INPP5J (if available)
    TreeFam Gene Tree for INPP5J (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for INPP5J gene
    INPP5B2  SYNJ12  OCRL2  INPP5D2  INPP5K2  INPP5E2  INPPL12  SYNJ22  
    2 SIMAP similar genes for INPP5J using alignment to 6 protein entries:     PI5PA_HUMAN (see all proteins):
    INPP5K    SYNJ1

    INPP5J for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/329 SNPs in INPP5J are shown (see all 329)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1848256151,2
    --31516973(+) GATTGA/CATGAA 1 -- us2k10--------
    rs117031581,2
    C,H--31517035(+) tctttC/Tttttt 1 -- us2k1 trp30--------
    rs622361591,2
    C--31517057(+) TGAGAA/CAGGGC 1 -- us2k10--------
    rs1895949861,2
    --31517097(+) TGGTAC/TGATCT 1 -- us2k10--------
    rs1456691351,2
    C--31517181(+) GACTAC/GAGGCA 1 -- us2k10--------
    rs1176929031,2
    C,F--31517201(+) ACACCC/TGGCTC 1 -- us2k11Minor allele frequency- T:0.03NA 120
    rs1475526691,2
    --31517316(+) GATTAC/TCCGCA 1 -- us2k10--------
    rs1419800041,2
    --31517328(+) TTTGCC/TAGTAC 1 -- us2k10--------
    rs1457959791,2
    --31517344(+) CAGCCC/TGGGGG 1 -- us2k10--------
    rs1930874981,2
    --31517345(+) AGCCCA/GGGGGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for INPP5J (31518717 - 31530683 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for INPP5J:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv829173CNV Loss20364138
    nsv914976CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing INPP5J
    DNA2.0 Custom Variant and Variant Library Synthesis for INPP5J

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606481    OMIM disorders: --

    6 diseases for INPP5J:    About MalaCards
    oculocerebrorenal syndrome    glanders    developmental disabilities    guillain-barre syndrome
    breast cancer    neuronitis


    INPP5J for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for INPP5J gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lowe syndrome 95 6 9430698 (1), 15353600 (1), 1321346 (1), 7762303 (1) (see all 5)
    developmental disabilities 25 1 7762303 (1)
    genetic disorder 11 1 9599410 (1)


    Export disorders for INPP5J gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for INPP5J gene, integrated from 9 sources (see all 80):
    (articles sorted by number of sources associating them with INPP5J)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2, 3 Dunham I....O'Brien K.P. (1999)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Identification of a novel domain in two mammalian inositol- polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase SKIP localizes to the endoplasmic reticulum and translocates to membrane ruffles following epidermal growth factor stimulation. (PubMed id 12536145)1, 9 Gurung R.... Mitchell C.A. (2003)
    5. PI(4,5)P2 5-phosphatase A regulates PI3K/Akt signallin g and has a tumour suppressive role in human melanoma. (PubMed id 23443536)1 Ye Y....Zhang X.D. (2013)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    7. The Protein Data Bank. (PubMed id 10592235)7 Berman H.M....Bourne P.E. (2000)
    8. Novel inositol polyphosphate 5-phosphatase localizes at membrane ruffles. (PubMed id 10593988)1 Mochizuki Y. and Takenawa T. (1999)
    9. A novel isoform of the smooth muscle cell differentiation marker smoothelin. (PubMed id 10023782)1 Kraemer J.... Leonhardt H. (1999)
    10. Toward a complete human genome sequence. (PubMed id 9847074)1 Wilson R. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27124 HGNC: 8956 AceView: PIB5PA Ensembl:ENSG00000185133 euGenes: HUgn27124
    ECgene: INPP5J Kegg: 27124 H-InvDB: INPP5J

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for INPP5J Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for INPP5J gene:
    Search GeneIP for patents involving INPP5J

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for INPP5J  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for INPP5J  
     OriGene MassSpec something-or-other for INPP5J   OriGene clones in human, mouse for INPP5J  
     OriGene qSTAR qPCR primer pairs in human, mouse for INPP5J   OriGene Purified Protein for INPP5J  
     OriGene ORF clones in mouse, rat for INPP5J   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for INPP5J   OriGene Custom Protein Services for INPP5J  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat INPP5J
     QIAGEN SeqTarget long-range PCR primers for resequencing INPP5J
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INPP5J
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat INPP5J
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INPP5J
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INPP5J
     GenScript Custom Purified and Recombinant Proteins Services for INPP5J GenScript cDNA clones with any tag delivered in your preferred vector for INPP5J
     GenScript Custom Assay Services for INPP5J GenScript Custom Superior Antibodies Services for INPP5J
     GenScript Custom overexpressing Cell Line Services for INPP5J CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in INPP5J promoter
     Search Chromatin IP Primers for INPP5J
     RT2 qPCR Primer Assay in human, mouse / rat INPP5J
     Search GNC Networks for INPP5J
     SABiosciences Custom PCR Arrays for INPP5J
     Search Tocris compounds for INPP5J (PI5PA)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for INPP5J
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     INPP5J antibodies
     INPP5J proteins
     INPP5J lysates
     Antibodies for INPP5J
     See all of Abcam's Antibodies, Kits and Proteins for INPP5J
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for INPP5J
     Antibodies for INPP5J
     ELISAs for INPP5J
     CLIAs for INPP5J
     Search LifeMap BioReagents cell lines for INPP5J
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INPP5J
     SwitchGear 3'UTR luciferase reporter plasmids for INPP5J
     SwitchGear Promoter luciferase reporter plasmids for INPP5J
     ThermoFisher Antibodies for INPP5J
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INPP5J
     inGenious Targeting Laboratory - Custom generated mouse model solutions for INPP5J
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for INPP5J
    Customized:
     lentivirus for stable overexpression of INPP5J
     lentivirus expression plasmids for stable overexpression of INPP5J
     adenovirus for overexpression of INPP5J
     LSBio Antibodies in human, mouse, rat for INPP5J
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      INPP5J gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4