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INPP5J Gene

protein-coding   GIFtS: 61
GCID: GC22P031518

Inositol Polyphosphate-5-Phosphatase J

(Previous names: phosphatidylinositol (4,5) bisphosphate 5-phosphatase, A)
(Previous symbol: PIB5PA)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Inositol Polyphosphate-5-Phosphatase J1 2     EC 3.1.3.563 8
PIB5PA1 2 3 5     INPP52
PIPP2 3 5     Phosphatidylinositol 4,5-Bisphosphate 5-Phosphatase A2
Phosphatidylinositol (4,5) Bisphosphate 5-Phosphatase, A1 2     EC 3.1.38
Inositol Polyphosphate 5-Phosphatase J2 3     

External Ids:    HGNC: 89561   Entrez Gene: 271242   Ensembl: ENSG000001851337   OMIM: 6064815   UniProtKB: Q157353   

Export aliases for INPP5J gene to outside databases

Previous GC identifers: GC22P029848 GC22P014480


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for INPP5J Gene:
INPP5J (inositol polyphosphate-5-phosphatase J) is a protein-coding gene. Diseases associated with INPP5J include oculocerebrorenal syndrome, and glanders. GO annotations related to this gene include SH3 domain binding and inositol-1,4,5-trisphosphate 5-phosphatase activity. An important paralog of this gene is INPP5E.

UniProtKB/Swiss-Prot: PI5PA_HUMAN, Q15735
Function: Inositol 5-phosphatase, which converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate. Also
converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate and inositol
1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function
of inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles (By
similarity)

Gene Wiki entry for INPP5J (PIB5PA) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000022.11  NT_011520.13  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the INPP5J gene promoter:
         Pax-5   Nkx2-5   Tal-1beta   E47   GATA-1   c-Myb   FOXO1a   FOXO1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidINPP5J promoter sequence
   Search Chromatin IP Primers for INPP5J

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat INPP5J


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.2   Ensembl cytogenetic band:  22q12.2   HGNC cytogenetic band: 22q12.2

INPP5J Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INPP5J gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P031518:  view genomic region     (about GC identifiers)

Start:
31,518,717 bp from pter      End:
31,530,683 bp from pter
Size:
11,967 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PI5PA_HUMAN, Q15735 (See protein sequence)
Recommended Name: Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A  
Size: 1006 amino acids; 107197 Da
Sequence caution: Sequence=AAD15618.1; Type=Erroneous gene model prediction;
Secondary accessions: B3KS54 Q32M61 Q6ZTH6 Q8N902 Q9UDT9
Alternative splicing: 3 isoforms:  Q15735-1   Q15735-2   Q15735-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for INPP5J: NX_Q15735

Explore proteomics data for INPP5J at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for INPP5J (Q15735) (see all 5)
     DYVAYVW  WDWIGLY  AIGLQEV  LWEKDQL 


    See INPP5J Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001002837.1  NP_001271214.1  NP_001271215.1  NP_001271216.1  NP_001271217.1  NP_001271218.1  

    ENSEMBL proteins: 
     ENSP00000401124   ENSP00000333262   ENSP00000406570   ENSP00000383150   ENSP00000384596  
     ENSP00000384534   ENSP00000385264   ENSP00000385343   ENSP00000384540   ENSP00000392924  
    Reactome Protein details: Q15735

    INPP5J Human Recombinant Protein Products:

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    Novus Biologicals INPP5J Protein
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    Cloud-Clone Corp. Proteins for INPP5J

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    Cloud-Clone Corp. CLIAs for INPP5J


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: INPP5J
    Inositol polyphosphate phosphatases

    2 InterPro protein domains:
     IPR000300 IPPc
     IPR005135 Endo/exonuclease/phosphatase

    Graphical View of Domain Structure for InterPro Entry Q15735

    ProtoNet protein and cluster: Q15735

    1 Blocks protein domain: IPB000300 Inositol polyphosphate related phosphatase family

    UniProtKB/Swiss-Prot: PI5PA_HUMAN, Q15735
    Domain: The 5 Arg-Ser-Xaa-Ser-Xaa-Xaa (RSXSXX) motifs may constitute binding sites for the 14-3-3 protein
    Similarity: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family


    INPP5J for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PI5PA_HUMAN, Q15735
    Function: Inositol 5-phosphatase, which converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate. Also
    converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate and inositol
    1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function
    of inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles (By
    similarity)
    Catalytic activity: D-myo-inositol 1,4,5-trisphosphate + H(2)O = myo-inositol 1,4-bisphosphate + phosphate
    Catalytic activity: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H(2)O = 1D-myo-inositol 1,3,4-trisphosphate +
    phosphate

         Enzyme Numbers (IUBMB): EC 3.1.3.561 2 EC 3.1.32

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004445inositol-polyphosphate 5-phosphatase activity IEA--
    GO:0017124SH3 domain binding IEA--
    GO:0034485phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity IEA--
    GO:0052658inositol-1,4,5-trisphosphate 5-phosphatase activity IEA--
    GO:0052659inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity IEA--
         
    INPP5J for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for INPP5J:
     Decreased focal adhesion (FA)   Increased apoptosis 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for INPP5J
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for INPP5J
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for INPP5J

    miRNA
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    miRTarBase miRNAs that target INPP5J:
    hsa-mir-26b-5p (MIRT030023), hsa-mir-346 (MIRT004238)

    Block miRNA regulation of human, mouse, rat INPP5J using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate INPP5J:
    hsa-miR-27a hsa-miR-219-5p hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmidINPP5J 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat INPP5J

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for INPP5J
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    GenScript: all cDNA clones in your preferred vector: INPP5J (NM_001002837)
    Sino Biological Human cDNA Clone for INPP5J
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INPP5J


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PI5PA_HUMAN, Q15735: Cytoplasm (By similarity). Note=Predominantly localized to membrane ruffles (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2
    plasma membrane2
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle IDA12536145
    GO:0005737cytoplasm IDA12536145
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IEA--
    GO:0030426growth cone IEA--

    INPP5J for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for INPP5J About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Inositol phosphate metabolism (KEGG)
    Inositol phosphate metabolism0.61
    D-myo-inositol (1,3,4)-trisphosphate biosynthesis0.00
    Phosphatidylinositol signaling system0.61
    D-myo-inositol (1,4,5)-trisphosphate degradation0.00
    superpathway of inositol phosphate compounds0.60
    1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)0.00
    superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism0.00
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38
    3Inositol phosphate metabolism (REACTOME)
    Inositol phosphate metabolism0.59
    Synthesis of IP2, IP, and Ins in the cytosol0.00
    Synthesis of IP3 and IP4 in the cytosol0.59
    4PI Metabolism
    PI Metabolism0.65
    Synthesis of PIPs at the plasma membrane0.65
    5Glycerophospholipid biosynthesis
    Phospholipid metabolism0.64

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected BioSystems Pathways for INPP5J (see all 6)
        1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)
    D-myo-inositol (1,3,4)-trisphosphate biosynthesis
    D-myo-inositol (1,4,5)-trisphosphate degradation
    3-phosphoinositide degradation
    superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism


    3 Reactome Pathways for INPP5J
        Synthesis of IP2, IP, and Ins in the cytosol
    Synthesis of PIPs at the plasma membrane
    Synthesis of IP3 and IP4 in the cytosol


    3 Kegg Pathways  (Kegg details for INPP5J):
        Inositol phosphate metabolism
    Metabolic pathways
    Phosphatidylinositol signaling system


    INPP5J for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for INPP5J
    Interactions:

        Search GeneGlobe Interaction Network for INPP5J

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for INPP5J (ENSP000003845344) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    INPP1ENSP000003254234STRING: ENSP00000325423
    INPP4AENSP000000743044STRING: ENSP00000074304
    IPMKENSP000003630464STRING: ENSP00000363046
    ITPK1ENSP000002676154STRING: ENSP00000267615
    ITPKAENSP000002603864STRING: ENSP00000260386
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    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006644phospholipid metabolic process TAS--
    GO:0006661phosphatidylinositol biosynthetic process TAS--
    GO:0010977negative regulation of neuron projection development IEA--
    GO:0031115negative regulation of microtubule polymerization IEA--
    GO:0033137negative regulation of peptidyl-serine phosphorylation IEA--

    INPP5J for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for INPP5J (PI5PA)

    6 HMDB Compounds for INPP5J    About this table
    CompoundSynonyms CAS #PubMed Ids
    1D-Myo-inositol 1,4-bisphosphate1D-Myo-inositol 1,4-bisphosphate (see all 5)47055-78-7--
    Inositol 1,3,4,5-tetraphosphate1,3,4,5-tetrakis(dihydrogen phosphate) myo-Inositol (see all 16)102850-29-3--
    Inositol 1,3,4-trisphosphate1,3,4-Itp (see all 8)98102-63-7--
    Inositol 1,4,5-trisphosphate1D-myo-Inositol 1,4,5-trisphosphate (see all 4)88269-39-0--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    1 DrugBank Compound for INPP5J    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Heme-- --target--10592235

    10 Novoseek inferred chemical compound relationships for INPP5J gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inositol 1,3,4,5-tetrakisphosphate 90 8 9430698 (1), 9525932 (1), 7556092 (1), 8529643 (1) (see all 8)
    phosphatidylinositol-3,4,5-trisphosphate 86.4 3 9430698 (1), 7556092 (1), 12556481 (1)
    inositol 81.8 20 1321346 (2), 11691828 (1), 15093605 (1), 9038219 (1) (see all 14)
    phosphoinositide 73.1 12 12018403 (2), 7556092 (1), 8968499 (1), 19272022 (1) (see all 9)
    inositol 1,4,5 trisphosphate 69.8 7 9430698 (1), 9525932 (1), 7556092 (1), 8529643 (1) (see all 7)
    phosphatidylinositol 69.2 6 9525932 (1), 19736566 (1), 12676785 (1), 8256286 (1) (see all 6)
    phosphatidylinositol 3-phosphate 58.9 2 16880518 (2)
    tyrosine 32 5 8805618 (1), 9838104 (1), 9009077 (1), 9232445 (1)
    calcium 7.34 4 8529643 (1), 9973602 (1), 1718960 (1)
    lipid 6.41 1 12018403 (1)



    INPP5J for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for INPP5J gene (7 alternative transcripts): 
    NM_014422.2  NM_001002837.2  NM_001284285.1  NM_001284286.1  NM_001284287.1  NM_001284288.1  NM_001284289.1  

    Unigene Cluster for INPP5J:

    Inositol polyphosphate-5-phosphatase J
    Hs.517549  [show with all ESTs]
    Unigene Representative Sequence: AK308921
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000463528 ENST00000412985 ENST00000331075(uc003ajt.4 uc003ajs.4 uc011alk.2 uc003aju.4 uc010gwg.3)
    ENST00000461241(uc003ajw.3) ENST00000420017 ENST00000400294 ENST00000405300(uc003ajv.4)
    ENST00000404390 ENST00000402238 ENST00000404453 ENST00000401755 ENST00000412277(uc010gwf.3)

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    SwitchGear 3'UTR luciferase reporter plasmidINPP5J 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: INPP5J (NM_001002837)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INPP5J
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat INPP5J
      QuantiFast Probe-based Assays in human, mouse, rat INPP5J

    Additional mRNA sequence: 

    AK126610.1 AK308921.1 AK309548.1 U45975.1 

    11 DOTS entries:

    DT.311553  DT.100024052  DT.100777877  DT.100753623  DT.100777879  DT.100806091  DT.101982761  DT.100687939 
    DT.100832177  DT.100778863  DT.120648431 

    Selected AceView cDNA sequences (see all 106):

    CR625511 BU507439 BP352955 AI540418 CR611668 CR617784 BU684668 CR615040 
    BF436472 AK126610 CR604969 BX102670 CR624482 BC041652 BM711841 CB107367 
    BU584792 CR617561 CA868401 CR599279 CR610046 BM994866 CR615918 BI522874 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for INPP5J (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a ·
    SP1:                                            -                             -                             -                                                   
    SP2:                                            -     -                       -                             -                                                   
    SP3:                                            -     -                 -     -                             -                                                   
    SP4:                                                                                                                                                            
    SP5:                                            -     -     -     -           -                                                                                 

    ExUns: 17b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for INPP5J

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    INPP5J expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGACTTCAT
    INPP5J Expression
    About this image


    INPP5J expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Ovary (Reproductive System)
             Cumulus Cells Antral Follicle
     
     Bone (Muscoskeletal System)
             Membranous Facial Bones
     
     Brain (Nervous System)
             Cerebellum
     
     Thyroid (Endocrine System)
    INPP5J Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    INPP5J Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.517549
        Custom PCR Arrays for INPP5J
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for INPP5J gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Inpp5j1 , 5 inositol polyphosphate 5-phosphatase J1, 5 81.39(n)1
    82.52(a)1
      11 (2.45 cM)5
    1708351  NM_172439.31  NP_766027.21 
     34943755 
    chicken
    (Gallus gallus)
    Aves INPP5J1 inositol polyphosphate-5-phosphatase J 71.53(n)
    72.71(a)
      416996  XM_415287.4  XP_415287.4 
    lizard
    (Anolis carolinensis)
    Reptilia INPP5J6
    inositol polyphosphate-5-phosphatase J
    57(a)
    1 ↔ 1
    GL343417.1(384204-396845)
    zebrafish
    (Danio rerio)
    Actinopterygii inpp5jb1 inositol polyphosphate-5-phosphatase Jb 65.56(n)
    64.45(a)
      100317089  XM_002662195.3  XP_002662241.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG68051 CG6805 53.33(n)
    44.56(a)
      36911  NM_001259450.2  NP_001246379.1 


    ENSEMBL Gene Tree for INPP5J (if available)
    TreeFam Gene Tree for INPP5J (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for INPP5J gene
    INPP5E2  INPPL12  INPP5B2  SYNJ12  OCRL2  INPP5D2  INPP5K2  SYNJ22  
    2 SIMAP similar genes for INPP5J using alignment to 6 protein entries:     PI5PA_HUMAN (see all proteins):
    INPP5K    SYNJ1

    INPP5J for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for INPP5J (see all 329)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1848256151,2
    --31516973(+) GATTGA/CATGAA 1 -- us2k10--------
    rs117031581,2
    C,H--31517035(+) tctttC/Tttttt 1 -- us2k1 trp30--------
    rs622361591,2
    C--31517057(+) TGAGAA/CAGGGC 1 -- us2k10--------
    rs1895949861,2
    --31517097(+) TGGTAC/TGATCT 1 -- us2k10--------
    rs1456691351,2
    C--31517181(+) GACTAC/GAGGCA 1 -- us2k10--------
    rs1176929031,2
    C,F--31517201(+) ACACCC/TGGCTC 1 -- us2k11Minor allele frequency- T:0.03NA 120
    rs1475526691,2
    --31517316(+) GATTAC/TCCGCA 1 -- us2k10--------
    rs1419800041,2
    --31517328(+) TTTGCC/TAGTAC 1 -- us2k10--------
    rs1457959791,2
    --31517344(+) CAGCCC/TGGGGG 1 -- us2k10--------
    rs1930874981,2
    --31517345(+) AGCCCA/GGGGGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for INPP5J (31518717 - 31530683 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for INPP5J:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv829173CNV Loss20364138
    nsv914976CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing INPP5J
    DNA2.0 Custom Variant and Variant Library Synthesis for INPP5J

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606481    OMIM disorders: --

    11 diseases for INPP5J:    
    About MalaCards
    oculocerebrorenal syndrome    glanders    guillain-barre syndrome    developmental disabilities
    malaria    hiv-1    cerebritis    breast cancer
    melanoma    neuronitis    thyroiditis


    INPP5J for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for INPP5J gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lowe syndrome 95 6 9430698 (1), 15353600 (1), 1321346 (1), 7762303 (1) (see all 5)
    developmental disabilities 25 1 7762303 (1)
    genetic disorder 11 1 9599410 (1)


    Export disorders for INPP5J gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for INPP5J gene, integrated from 10 sources (see all 80):
    (articles sorted by number of sources associating them with INPP5J)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2, 3 Dunham I.... Wright H. (Nature 1999)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Identification of a novel domain in two mammalian inositol- polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase SKIP localizes to the endoplasmic reticulum and translocates to membrane ruffles following epidermal growth factor stimulation. (PubMed id 12536145)1, 9 Gurung R.... Mitchell C.A. (J. Biol. Chem. 2003)
    5. PI(4,5)P2 5-phosphatase A regulates PI3K/Akt signalling and has a tumour suppressive role in human melanoma. (PubMed id 23443536)1 Ye Y....Zhang X.D. (Nat Commun 2013)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    7. The Protein Data Bank. (PubMed id 10592235)7 Berman H.M....Bourne P.E. (Nucleic Acids Res. 2000)
    8. Novel inositol polyphosphate 5-phosphatase localizes at membrane ruffles. (PubMed id 10593988)1 Mochizuki Y. and Takenawa T. (J. Biol. Chem. 1999)
    9. A novel isoform of the smooth muscle cell differentiation marker smoothelin. (PubMed id 10023782)1 Kraemer J.... Leonhardt H. (J. Mol. Med. 1999)
    10. Toward a complete human genome sequence. (PubMed id 9847074)1 Sulston J.E. and Waterston R. (Genome Res. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27124 HGNC: 8956 AceView: PIB5PA Ensembl:ENSG00000185133 euGenes: HUgn27124
    ECgene: INPP5J Kegg: 27124 H-InvDB: INPP5J

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for INPP5J Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for INPP5J gene:
    Search GeneIP for patents involving INPP5J

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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