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Aliases for INPP5J Gene

Aliases for INPP5J Gene

  • Inositol Polyphosphate-5-Phosphatase J 2 3
  • PIB5PA 3 4 6
  • PIPP 3 4 6
  • Phosphatidylinositol (4,5) Bisphosphate 5-Phosphatase, A 2 3
  • Inositol Polyphosphate 5-Phosphatase J 3 4
  • EC 3.1.3.56 4 63
  • Phosphatidylinositol 4,5-Bisphosphate 5-Phosphatase A 3
  • EC 3.1.3 63
  • INPP5 3

External Ids for INPP5J Gene

Previous HGNC Symbols for INPP5J Gene

  • PIB5PA

Previous GeneCards Identifiers for INPP5J Gene

  • GC22P029848
  • GC22P031518
  • GC22P014480

Summaries for INPP5J Gene

GeneCards Summary for INPP5J Gene

INPP5J (Inositol Polyphosphate-5-Phosphatase J) is a Protein Coding gene. Diseases associated with INPP5J include oculocerebrorenal syndrome. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include SH3 domain binding and inositol-1,4,5-trisphosphate 5-phosphatase activity. An important paralog of this gene is SYNJ2.

UniProtKB/Swiss-Prot for INPP5J Gene

  • Inositol 5-phosphatase, which converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles (By similarity).

Gene Wiki entry for INPP5J Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INPP5J Gene

Genomics for INPP5J Gene

Regulatory Elements for INPP5J Gene

Genomic Location for INPP5J Gene

Start:
31,109,979 bp from pter
End:
31,134,697 bp from pter
Size:
24,719 bases
Orientation:
Plus strand

Genomic View for INPP5J Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for INPP5J Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INPP5J Gene

Proteins for INPP5J Gene

  • Protein details for INPP5J Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15735-PI5PA_HUMAN
    Recommended name:
    Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A
    Protein Accession:
    Q15735
    Secondary Accessions:
    • B3KS54
    • Q32M61
    • Q6ZTH6
    • Q8N902
    • Q9UDT9

    Protein attributes for INPP5J Gene

    Size:
    1006 amino acids
    Molecular mass:
    107197 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD15618.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for INPP5J Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for INPP5J Gene

Proteomics data for INPP5J Gene at MOPED

Selected DME Specific Peptides for INPP5J Gene

Post-translational modifications for INPP5J Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for INPP5J Gene

Gene Families for INPP5J Gene

Protein Domains for INPP5J Gene

Graphical View of Domain Structure for InterPro Entry

Q15735

UniProtKB/Swiss-Prot:

PI5PA_HUMAN :
  • Q15735
Domain:
  • The 5 Arg-Ser-Xaa-Ser-Xaa-Xaa (RSXSXX) motifs may constitute binding sites for the 14-3-3 protein
Family:
  • Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.
genes like me logo Genes that share domains with INPP5J: view

Function for INPP5J Gene

Molecular function for INPP5J Gene

UniProtKB/Swiss-Prot CatalyticActivity: D-myo-inositol 1,4,5-trisphosphate + H(2)O = myo-inositol 1,4-bisphosphate + phosphate
UniProtKB/Swiss-Prot CatalyticActivity: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H(2)O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate
UniProtKB/Swiss-Prot Function: Inositol 5-phosphatase, which converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles (By similarity).

Enzyme Numbers (IUBMB) for INPP5J Gene

Gene Ontology (GO) - Molecular Function for INPP5J Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004445 inositol-polyphosphate 5-phosphatase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0017124 SH3 domain binding IEA --
GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity IEA --
GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity IEA --
genes like me logo Genes that share ontologies with INPP5J: view

Phenotypes for INPP5J Gene

GenomeRNAi human phenotypes for INPP5J:
genes like me logo Genes that share phenotypes with INPP5J: view

Animal Model Products

CRISPR Products

miRNA for INPP5J Gene

miRTarBase miRNAs that target INPP5J

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for INPP5J Gene

Localization for INPP5J Gene

Subcellular locations from UniProtKB/Swiss-Prot for INPP5J Gene

Cytoplasm. Note=Predominantly localized to membrane ruffles. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for INPP5J Gene COMPARTMENTS Subcellular localization image for INPP5J gene
Compartment Confidence
cytosol 4
nucleus 2
plasma membrane 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for INPP5J Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IDA 12536145
GO:0005737 cytoplasm IDA 12536145
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
GO:0030426 growth cone IEA --
genes like me logo Genes that share ontologies with INPP5J: view

Pathways for INPP5J Gene

genes like me logo Genes that share pathways with INPP5J: view

Gene Ontology (GO) - Biological Process for INPP5J Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process TAS --
GO:0006661 phosphatidylinositol biosynthetic process TAS --
GO:0010977 negative regulation of neuron projection development IEA --
GO:0031115 negative regulation of microtubule polymerization IEA --
GO:0033137 negative regulation of peptidyl-serine phosphorylation IEA --
genes like me logo Genes that share ontologies with INPP5J: view

Compounds for INPP5J Gene

(6) HMDB Compounds for INPP5J Gene

Compound Synonyms Cas Number PubMed IDs
1D-Myo-inositol 1,4-bisphosphate
  • 1D-Myo-inositol 1,4-bisphosphate
47055-78-7
Inositol 1,3,4,5-tetraphosphate
  • 1,3,4,5-tetrakis(dihydrogen phosphate) myo-Inositol
102850-29-3
Inositol 1,3,4-trisphosphate
  • 1,3,4-Itp
98102-63-7
Inositol 1,4,5-trisphosphate
  • 1D-myo-Inositol 1,4,5-trisphosphate
88269-39-0
Phosphate
  • NFB Orthophosphate
14265-44-2

(1) Drugbank Compounds for INPP5J Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Heme
target

(10) Novoseek inferred chemical compound relationships for INPP5J Gene

Compound -log(P) Hits PubMed IDs
inositol 1,3,4,5-tetrakisphosphate 90 8
phosphatidylinositol-3,4,5-trisphosphate 86.4 3
inositol 81.8 15
phosphoinositide 73.1 10
inositol 1,4,5 trisphosphate 69.8 7
genes like me logo Genes that share compounds with INPP5J: view

Transcripts for INPP5J Gene

Unigene Clusters for INPP5J Gene

Inositol polyphosphate-5-phosphatase J:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for INPP5J

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for INPP5J
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for INPP5J Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a ·
SP1: - - -
SP2: - - - -
SP3: - - - - -
SP4:
SP5: - - - - -
SP6: - - -
SP7: -
SP8: - - - - -
SP9:
SP10: - - - - - -

ExUns: 17b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for INPP5J Gene

GeneLoc Exon Structure for
INPP5J
ECgene alternative splicing isoforms for
INPP5J

Expression for INPP5J Gene

mRNA expression in normal human tissues for INPP5J Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for INPP5J Gene

This gene is overexpressed in Thyroid (16.4), Brain - Cerebellum (5.1), and Brain - Cerebellar Hemisphere (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for INPP5J Gene

SOURCE GeneReport for Unigene cluster for INPP5J Gene Hs.517549

genes like me logo Genes that share expressions with INPP5J: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for INPP5J Gene

Orthologs for INPP5J Gene

This gene was present in the common ancestor of animals.

Orthologs for INPP5J Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INPP5J 35
  • 99.14 (n)
  • 99.01 (a)
INPP5J 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia INPP5J 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia INPP5J 35
  • 87.52 (n)
  • 87.95 (a)
INPP5J 36
  • 59 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Inpp5j 35
  • 81.39 (n)
  • 82.52 (a)
Inpp5j 16
Inpp5j 36
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia INPP5J 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia INPP5J 36
  • 52 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Inpp5j 35
  • 82.25 (n)
  • 84.28 (a)
chicken
(Gallus gallus)
Aves INPP5J 35
  • 71.53 (n)
  • 72.71 (a)
INPP5J 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia INPP5J 36
  • 57 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii inpp5ja 36
  • 40 (a)
OneToMany
inpp5jb 35
  • 65.56 (n)
  • 64.45 (a)
inpp5jb 36
  • 47 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6805 35
  • 53.33 (n)
  • 44.56 (a)
CG6805 36
  • 36 (a)
ManyToMany
CG9784 36
  • 28 (a)
ManyToMany
Species with no ortholog for INPP5J:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for INPP5J Gene

ENSEMBL:
Gene Tree for INPP5J (if available)
TreeFam:
Gene Tree for INPP5J (if available)

Paralogs for INPP5J Gene

Paralogs for INPP5J Gene

Selected SIMAP similar genes for INPP5J Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with INPP5J: view

Variants for INPP5J Gene

Sequence variations from dbSNP and Humsavar for INPP5J Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs728206 -- 31,133,786(-) AAGGA(A/G)CAGAA intron-variant
rs1468411 -- 31,130,658(-) AATAA(C/T)GAATG intron-variant
rs1807739 -- 31,115,405(-) accca(C/T)gccca intron-variant
rs2017301 -- 31,118,491(-) AGACT(A/G)AAGAC intron-variant
rs2240428 -- 31,122,964(-) CTCTA(C/T)CGCTC utr-variant-5-prime, missense, reference

Structural Variations from Database of Genomic Variants (DGV) for INPP5J Gene

Variant ID Type Subtype PubMed ID
nsv829173 CNV Loss 20364138
nsv914976 CNV Loss 21882294

Relevant External Links for INPP5J Gene

HapMap Linkage Disequilibrium report
INPP5J

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INPP5J Gene

Disorders for INPP5J Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for INPP5J Gene including...

Search for INPP5J Gene in MalaCards »

(3) Novoseek inferred disease relationships for INPP5J Gene

Disease -log(P) Hits PubMed IDs
lowe syndrome 95 5
developmental disabilities 25 1
genetic disorder 11 1
genes like me logo Genes that share disorders with INPP5J: view

No data available for UniProtKB/Swiss-Prot for INPP5J Gene

Publications for INPP5J Gene

  1. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Identification of a novel domain in two mammalian inositol- polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase SKIP localizes to the endoplasmic reticulum and translocates to membrane ruffles following epidermal growth factor stimulation. (PMID: 12536145) Gurung R. … Mitchell C.A. (J. Biol. Chem. 2003) 3 23
  5. SKIP negatively regulates insulin-induced GLUT4 translocation and membrane ruffle formation. (PMID: 12556481) Ijuin T. … Takenawa T. (Mol. Cell. Biol. 2003) 23

Products for INPP5J Gene

  • antibodies-online proteins for INPP5J
  • antibodies-online antibodies for INPP5J
  • antibodies-online kits for INPP5J

Sources for INPP5J Gene

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