Aliases for INPP5F Gene
- Inositol Polyphosphate-5-Phosphatase F 2 3 5
- Sac Domain-Containing Phosphoinositide 4-Phosphatase 2 3 4
- Sac Domain-Containing Inositol Phosphatase 2 3 4
- HSAC2 3 4
- SAC2 3 4
- Sac Domain-Containing Phosphoinositide 5-Phosphatase 2 3
- Phosphatidylinositide Phosphatase SAC2 3
- Inositol Polyphosphate 5-Phosphatase F 4
External Ids for INPP5F Gene
Previous GeneCards Identifiers for INPP5F Gene
The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase and contains a Sac domain. The activity of this protein is specific for phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
GeneCards Summary for INPP5F Gene
INPP5F (Inositol Polyphosphate-5-Phosphatase F) is a Protein Coding gene. Among its related pathways are Inositol phosphate metabolism (KEGG) and 3-phosphoinositide degradation. GO annotations related to this gene include phosphoric ester hydrolase activity. An important paralog of this gene is SACM1L.
UniProtKB/Swiss-Prot for INPP5F Gene
Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling (PubMed:25869669). Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms (PubMed:25869669). Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation (PubMed:17322895). Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus (PubMed:25476455). Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (By similarity). May play a role as negative regulator of axon regeneration after central nervous system injuries (By similarity).