Free for academic non-profit institutions. Other users need a Commercial license

Aliases for INPP5F Gene

Aliases for INPP5F Gene

  • Inositol Polyphosphate-5-Phosphatase F 2 3 5
  • Sac Domain-Containing Phosphoinositide 4-Phosphatase 2 3 4
  • Sac Domain-Containing Inositol Phosphatase 2 3 4
  • HSAC2 3 4
  • SAC2 3 4
  • Sac Domain-Containing Phosphoinositide 5-Phosphatase 2 3
  • Phosphatidylinositide Phosphatase SAC2 3
  • Inositol Polyphosphate 5-Phosphatase F 4
  • EC 3.1.3.16 61
  • EC 3.1.3.36 61
  • EC 3.1.3.25 4
  • KIAA0966 4
  • EC 3.1.3 61
  • MSTP007 3
  • MSTPO47 3

External Ids for INPP5F Gene

Previous GeneCards Identifiers for INPP5F Gene

  • GC10P121616
  • GC10P121150
  • GC10P121475
  • GC10P115115
  • GC10P121485
  • GC10P119726

Summaries for INPP5F Gene

Entrez Gene Summary for INPP5F Gene

  • The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase and contains a Sac domain. The activity of this protein is specific for phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for INPP5F Gene

INPP5F (Inositol Polyphosphate-5-Phosphatase F) is a Protein Coding gene. Among its related pathways are Metabolism and Inositol phosphate metabolism (KEGG). GO annotations related to this gene include phosphoric ester hydrolase activity. An important paralog of this gene is SACM1L.

UniProtKB/Swiss-Prot for INPP5F Gene

  • Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling (PubMed:25869669). Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms (PubMed:25869669). Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation (PubMed:17322895). Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus (PubMed:25476455). Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (By similarity). May play a role as negative regulator of axon regeneration after central nervous system injuries (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INPP5F Gene

Genomics for INPP5F Gene

Regulatory Elements for INPP5F Gene

Enhancers for INPP5F Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F119783 1.5 FANTOM5 Ensembl ENCODE 27.8 +81.2 81206 4.8 ATF1 ARID4B FEZF1 DMAP1 YY1 GTF3C2 ZNF121 ZNF202 SP5 JUNB SEC23IP RPL17P36 INPP5F RPL21P16 MCMBP TXNP1 RN7SL846P GC10M119816
GH10F119759 0.9 Ensembl ENCODE 24 +56.7 56664 2.5 TBP THRB RARA ZNF121 FOS CREM SP5 CEBPB KAT8 KLF16 INPP5F SEC23IP RPL17P36 MCMBP RPL21P16 PHACTR2P1 GC10P119759 RN7SL846P
GH10F119848 0.2 ENCODE 20.2 +145.3 145301 3.1 CTCF RAD21 ZNF48 ZEB1 ZNF664 HIC1 ZFHX2 PATZ1 SMC3 ZBTB20 INPP5F MCMBP SEC23IP BAG3 ENSG00000222588 SNORA19 EIF3A ENSG00000282413
GH10F119677 0.9 Ensembl ENCODE 18.9 -23.8 -23825 5.3 TBP KLF17 RAD21 GTF3C2 ZNF121 GLIS2 SMARCC2 ZNF548 FOS EGR2 SEC23IP MCMBP RPL17P36 INPP5F PHACTR2P1 TXNP1 BAG3
GH10F119618 1.1 Ensembl ENCODE 18.6 -84.7 -84694 3.0 GATA3 MAZ HLF CEBPB PRDM10 REST SP7 SPI1 INPP5F BAG3 TIAL1 RAD1P1 GC10P119612
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around INPP5F on UCSC Golden Path with GeneCards custom track

Genomic Location for INPP5F Gene

Chromosome:
10
Start:
119,704,395 bp from pter
End:
119,829,278 bp from pter
Size:
124,884 bases
Orientation:
Plus strand

Genomic View for INPP5F Gene

Genes around INPP5F on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INPP5F Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INPP5F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INPP5F Gene

Proteins for INPP5F Gene

  • Protein details for INPP5F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2H2-SAC2_HUMAN
    Recommended name:
    Phosphatidylinositide phosphatase SAC2
    Protein Accession:
    Q9Y2H2
    Secondary Accessions:
    • B3KRF1
    • D3DRD1
    • Q2T9J4
    • Q5W135
    • Q5W136
    • Q6NVY2
    • Q86U97
    • Q9H3D9
    • Q9NT51

    Protein attributes for INPP5F Gene

    Size:
    1132 amino acids
    Molecular mass:
    128407 Da
    Quaternary structure:
    • Homodimer (PubMed:25869669). Interacts with OCRL and RAB5A (PubMed:25869668). Interacts with INPP5B and INPP4A (PubMed:25869668). Interacts with STAT3; the interaction is independent of STAT3 TYR-705 phosphorylation status (PubMed:25476455).
    SequenceCaution:
    • Sequence=BAA76810.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for INPP5F Gene

    Alternative splice isoforms for INPP5F Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for INPP5F Gene

Selected DME Specific Peptides for INPP5F Gene

Post-translational modifications for INPP5F Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for INPP5F Gene

Gene Families for INPP5F Gene

Protein Domains for INPP5F Gene

Suggested Antigen Peptide Sequences for INPP5F Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y2H2

UniProtKB/Swiss-Prot:

SAC2_HUMAN :
  • Contains 1 hSac2 domain.
Domain:
  • Contains 1 hSac2 domain.
  • Contains 1 SAC domain.
genes like me logo Genes that share domains with INPP5F: view

Function for INPP5F Gene

Molecular function for INPP5F Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=14.3 uM for PtdIns(4,5)P2 (at pH 6.0) {ECO:0000269 PubMed:11274189};
UniProtKB/Swiss-Prot CatalyticActivity:
Myo-inositol phosphate + H(2)O = myo-inositol + phosphate.
UniProtKB/Swiss-Prot Function:
Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling (PubMed:25869669). Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms (PubMed:25869669). Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation (PubMed:17322895). Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus (PubMed:25476455). Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (By similarity). May play a role as negative regulator of axon regeneration after central nervous system injuries (By similarity).

Enzyme Numbers (IUBMB) for INPP5F Gene

Gene Ontology (GO) - Molecular Function for INPP5F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25476455
GO:0008934 inositol monophosphate 1-phosphatase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0034595 NOT phosphatidylinositol phosphate 5-phosphatase activity IDA 25869669
GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity TAS --
genes like me logo Genes that share ontologies with INPP5F: view
genes like me logo Genes that share phenotypes with INPP5F: view

Animal Model Products

  • Taconic Biosciences Mouse Models for INPP5F

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for INPP5F Gene

Localization for INPP5F Gene

Subcellular locations from UniProtKB/Swiss-Prot for INPP5F Gene

Membrane, clathrin-coated pit. Early endosome. Recycling endosome. Note=Also found on macropinosomes. {ECO:0000250 UniProtKB:Q8CDA1}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for INPP5F Gene COMPARTMENTS Subcellular localization image for INPP5F gene
Compartment Confidence
endosome 5
cytosol 3
cytoskeleton 2
nucleus 2

Gene Ontology (GO) - Cellular Components for INPP5F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IEA --
GO:0005769 early endosome IEA,IDA 25869669
GO:0005905 colocalizes_with clathrin-coated pit IEA,IDA 25869669
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with INPP5F: view

Pathways & Interactions for INPP5F Gene

genes like me logo Genes that share pathways with INPP5F: view

Gene Ontology (GO) - Biological Process for INPP5F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001921 positive regulation of receptor recycling IDA 25869669
GO:0006661 phosphatidylinositol biosynthetic process TAS --
GO:0008344 adult locomotory behavior IEA --
GO:0014898 cardiac muscle hypertrophy in response to stress ISS --
GO:0031161 phosphatidylinositol catabolic process ISS --
genes like me logo Genes that share ontologies with INPP5F: view

No data available for SIGNOR curated interactions for INPP5F Gene

Transcripts for INPP5F Gene

Unigene Clusters for INPP5F Gene

Inositol polyphosphate-5-phosphatase F:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for INPP5F Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c ^ 18 ^
SP1: - - - - -
SP2:
SP3: -
SP4:
SP5:
SP6:

ExUns: 19 ^ 20 ^ 21 ^ 22a · 22b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for INPP5F Gene

GeneLoc Exon Structure for
INPP5F
ECgene alternative splicing isoforms for
INPP5F

Expression for INPP5F Gene

mRNA expression in normal human tissues for INPP5F Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for INPP5F Gene

This gene is overexpressed in Brain - Hypothalamus (x5.4) and Brain - Frontal Cortex (BA9) (x4.1).

Protein differential expression in normal tissues from HIPED for INPP5F Gene

This gene is overexpressed in Breast (30.2) and Fetal Brain (20.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for INPP5F Gene



NURSA nuclear receptor signaling pathways regulating expression of INPP5F Gene:

INPP5F

SOURCE GeneReport for Unigene cluster for INPP5F Gene:

Hs.369755

mRNA Expression by UniProt/SwissProt for INPP5F Gene:

Q9Y2H2-SAC2_HUMAN
Tissue specificity: Ubiquitous (PubMed:11274189). Highly expressed in brain (PubMed:26203138).
genes like me logo Genes that share expression patterns with INPP5F: view

Primer Products

No data available for Protein tissue co-expression partners for INPP5F Gene

Orthologs for INPP5F Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for INPP5F Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INPP5F 34 35
  • 99.76 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 94 (a)
OneToMany
-- 35
  • 87 (a)
OneToMany
-- 35
  • 67 (a)
OneToMany
dog
(Canis familiaris)
Mammalia INPP5F 34 35
  • 92.13 (n)
cow
(Bos Taurus)
Mammalia INPP5F 34
  • 91.83 (n)
-- 35
  • 87 (a)
OneToMany
-- 35
  • 79 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Inpp5f 34
  • 87.09 (n)
oppossum
(Monodelphis domestica)
Mammalia INPP5F 35
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Inpp5f 34 16 35
  • 86.93 (n)
chicken
(Gallus gallus)
Aves INPP5F 34 35
  • 78.34 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 82 (a)
OneToMany
-- 35
  • 75 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia inpp5f 34
  • 68.86 (n)
zebrafish
(Danio rerio)
Actinopterygii inpp5f 34 35
  • 68.85 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000483 34
  • 48.93 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7956 34 35
  • 48.53 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_W09C5.7 34
  • 48.05 (n)
W09C5.7 35
  • 32 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SAC1 35
  • 28 (a)
OneToMany
Species where no ortholog for INPP5F was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for INPP5F Gene

ENSEMBL:
Gene Tree for INPP5F (if available)
TreeFam:
Gene Tree for INPP5F (if available)

Paralogs for INPP5F Gene

Paralogs for INPP5F Gene

Pseudogenes.org Pseudogenes for INPP5F Gene

genes like me logo Genes that share paralogs with INPP5F: view

Variants for INPP5F Gene

Sequence variations from dbSNP and Humsavar for INPP5F Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1024661 -- 119,767,894(+) AATAT(A/G)TATAA intron-variant
rs1024662 -- 119,767,896(+) TATAT(A/T)TAAAA intron-variant
rs1024663 -- 119,768,106(+) TGTGG(A/C)GTTTT intron-variant
rs1034942 -- 119,767,889(+) CTATA(A/T)ATATA intron-variant
rs10450433 -- 119,828,999(+) AGCTT(A/T)ACTCT downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for INPP5F Gene

Variant ID Type Subtype PubMed ID
esv1309933 CNV deletion 17803354
esv2678096 CNV deletion 23128226
esv3624715 CNV loss 21293372
nsv1045668 CNV gain 25217958
nsv1115231 CNV deletion 24896259
nsv478555 CNV novel sequence insertion 20440878
nsv825585 CNV gain 20364138

Variation tolerance for INPP5F Gene

Residual Variation Intolerance Score: 24.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.72; 66.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for INPP5F Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
INPP5F

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INPP5F Gene

Disorders for INPP5F Gene

Relevant External Links for INPP5F

Genetic Association Database (GAD)
INPP5F
Human Genome Epidemiology (HuGE) Navigator
INPP5F
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
INPP5F

No disorders were found for INPP5F Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for INPP5F Gene

Publications for INPP5F Gene

  1. Identification and characterization of a sac domain-containing phosphoinositide 5-phosphatase. (PMID: 11274189) Minagawa T. … Takenawa T. (J. Biol. Chem. 2001) 2 3 4 22 64
  2. Spatiotemporal control of phosphatidylinositol 4-phosphate by Sac2 regulates endocytic recycling. (PMID: 25869669) Hsu F. … Mao Y. (J. Cell Biol. 2015) 2 3 4 64
  3. Sac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway. (PMID: 25869668) Nakatsu F. … De Camilli P. (J. Cell Biol. 2015) 3 4 64
  4. Inositol Polyphosphate-5-Phosphatase F (INPP5F) inhibits STAT3 activity and suppresses gliomas tumorigenicity. (PMID: 25476455) Kim H.S. … Zhang W. (Sci Rep 2014) 3 4 64
  5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 64

Products for INPP5F Gene

Sources for INPP5F Gene

Content
Loading form....