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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

INPP5F Gene

protein-coding   GIFtS: 55
GCID: GC10P121475

inositol polyphosphate-5-phosphatase F
 Explore 2 diseases affiliated with
INPP5F via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for INPP5F    

Aliases
for INPP5F gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Inositol Polyphosphate-5-Phosphatase F1 2     MSTPO472
SAC21 2 3     Phosphatidylinositide Phosphatase SAC22
KIAA09661 3     EC 3.1.3.-3
Sac Domain-Containing Phosphoinositide 5-Phosphatase 22 3     Inositol Polyphosphate 5-Phosphatase F3
HSAC21     EC 3.1.38
Sac Domain-Containing Inositol Phosphatase 22 3     EC 3.1.3.168
HSac21     EC 3.1.3.368

External Ids:    HGNC: 170541   Entrez Gene: 228762   Ensembl: ENSG000001988257   OMIM: 6093895   UniProtKB: Q9Y2H23   
ORGUL members:         
NONCODE:n405969    

Export aliases for INPP5F gene to outside databases

Previous GC identifers: GC10P121616 GC10P121150 GC10P115115


Summaries
for INPP5F gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for INPP5F:
The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase and contains a Sac domain.
The activity of this protein is specific for phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol
3,4,5-trisphosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this
gene. (provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: SAC2_HUMAN, Q9Y2H2
Function: Inositol 5-phosphatase which acts on phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol
3,4,5-trisphosphate. Hydrolyzes phosphatidylinositol 4,5-bisphosphate most effectively. Modulates AKT/GSK3B pathway by
decreasing AKT and GSK3B phosphorylation




Genomic Views
for INPP5F gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the INPP5F gene promoter:
         TBP   AML1a   FOXF2   MIF-1   RORalpha2   S8   PPAR-gamma1   TFIID   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: INPP5F promoter sequence
   Search SABiosciences Chromatin IP Primers for INPP5F

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INPP5F


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.11   Ensembl cytogenetic band:  10q26.11   HGNC cytogenetic band: 10q26.13

INPP5F Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INPP5F gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P121475:  view genomic region     (about GC identifiers)

Start:
 121,485,609 bp from pter      End:
 121,588,659 bp from pter
Size:
 103,051 bases      Orientation:
 plus strand

Proteins
for INPP5F gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SAC2_HUMAN, Q9Y2H2 (See protein sequence)
Recommended Name: Phosphatidylinositide phosphatase SAC2  
Size: 1132 amino acids; 128407 Da
Miscellaneous: Inositol polyphosphate 5-phosphatases usually have 2 conserved motifs that are essential for
5-phosphatase activity. However, INPP5F does not contain such motifs, and phosphatase activity seems to exist in the
SAC domain, suggesting a new type of phosphoinositide 5-phosphatase
Sequence caution: Sequence=BAA76810.2; Type=Erroneous initiation;
Secondary accessions: D3DRD1 Q2T9J4 Q5W136 Q6NVY2 Q86U97 Q9H3D9 Q9NT51
Alternative splicing: 3 isoforms:  Q9Y2H2-1   Q9Y2H2-2   Q9Y2H2-3   

Explore the universe of human proteins at neXtProt for INPP5F: NX_Q9Y2H2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y2H2

    • 4/5 DME Specific Peptides for INPP5F (Q9Y2H2) (see all 5)
     IGDAYLK  FVQTRGS  QTRGSVP  DCLDRTN 

    INPP5F Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001230123.1  NP_001230124.1  NP_055752.1  

    ENSEMBL proteins: 
     ENSP00000354519   ENSP00000358077   ENSP00000358076   ENSP00000358079  

    Human Recombinant Protein Products: 
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    Uscn Proteins for INPP5F


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    ThermoFisher Antibody for INPP5F

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    Uscn ELISAs and CLIAs for INPP5F

    Protein Domains /
    Families
    for INPP5F gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    INPP5F for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR022158 Inositol_phosphatase
     IPR002013 Syja_N

    Graphical View of Domain Structure for InterPro Entry Q9Y2H2

    ProtoNet protein and cluster: Q9Y2H2

    1 Blocks protein family: IPB002013 Synaptojanin

    UniProtKB/Swiss-Prot: SAC2_HUMAN, Q9Y2H2
    Similarity: Contains 1 SAC domain


    Function
    for INPP5F gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SAC2_HUMAN, Q9Y2H2
    Function: Inositol 5-phosphatase which acts on phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol
    3,4,5-trisphosphate. Hydrolyzes phosphatidylinositol 4,5-bisphosphate most effectively. Modulates AKT/GSK3B pathway by
    decreasing AKT and GSK3B phosphorylation
    Biophysicochemical properties: Kinetic parameters: KM=14.3 uM for PtdIns(4,5)P2 (at pH 6.0);

    Enzyme Numbers (IUBMB): EC 3.1.3.362 EC 3.1.32 EC 3.1.3.162 EC 3.1.3.-1

    miRNA
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    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate INPP5F (see all 12):
    hsa-miR-142-3p hsa-miR-495 hsa-miR-548d-3p hsa-miR-548am hsa-miR-7-2* hsa-miR-20b* hsa-miR-421 hsa-miR-105
    SwitchGear 3'UTR luciferase reporter plasmid: INPP5F 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for INPP5F (see all 7)
    OriGene shRNA RFP: INPP5F
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for INPP5F

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INPP5F

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042578phosphoric ester hydrolase activity IEA--


    INPP5F for ontologies           About GeneDecksing


    Animal Models:
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Inpp5f):
     cardiovascular system  cellular  homeostasis/metabolism  muscle 

    INPP5F for phenotypes           About GeneDecksing


    Pathways & Interactions
    for INPP5F gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1D-myo-inositol (1,3,4)-trisphosphate biosynthesis
    		superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism0.75
    		3-phosphoinositide degradation0.33
    		D-myo-inositol (1,4,5)-trisphosphate degradation0.40


    3 BioSystems Pathways for INPP5F 
        D-myo-inositol (1,4,5)-trisphosphate degradation
    superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism
    3-phosphoinositide degradation


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for INPP5F

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/6 Interacting proteins for INPP5F (ENSP000003545194) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTENENSP000003610214STRING: ENSP00000361021
    SACM1LENSP000003737134STRING: ENSP00000373713
    INPP1ENSP000003254234STRING: ENSP00000325423
    INPP4AENSP000000743044STRING: ENSP00000074304
    INPP4BENSP000002629924STRING: ENSP00000262992
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0014898cardiac muscle hypertrophy in response to stress IEA--
    GO:0031161phosphatidylinositol catabolic process IEA--
    GO:0048015phosphatidylinositol-mediated signaling IEA--


    INPP5F for ontologies           About GeneDecksing



    Drugs & Compounds
    for INPP5F gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for INPP5F
    Search CenterWatch for drugs/clinical trials and news about INPP5F / SAC2 

    Transcripts
    for INPP5F gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for INPP5F gene (3 alternative transcripts): 
    NM_001243194.1  NM_001243195.1  NM_014937.3  

    Unigene Cluster for INPP5F:

    Inositol polyphosphate-5-phosphatase F
    Hs.369755  [show with all ESTs]
    Unigene Representative Sequence: NM_014937
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361976(uc001leo.3 uc001lep.3) ENST00000369081 ENST00000369080
    ENST00000490818 ENST00000369083(uc001len.4)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: INPP5F
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat INPP5F
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate INPP5F (see all 12):
    hsa-miR-142-3p hsa-miR-495 hsa-miR-548d-3p hsa-miR-548am hsa-miR-7-2* hsa-miR-20b* hsa-miR-421 hsa-miR-105
    SwitchGear 3'UTR luciferase reporter plasmid: INPP5F 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for INPP5F (see all 7)
    OriGene shRNA RFP: INPP5F
    OriGene siRNA: INPP5F
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat INPP5F
    Clone
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    GenScript: all cDNA clones in your preferred vector: INPP5F (NM_014937)
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    Primer
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat INPP5F
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INPP5F
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INPP5F

    Additional cDNA sequence: 

    AB023183.1 AF109361.1 AF113227.1 AK091448.1 AK123633.1 AK307758.1 AL137528.1 BC052367.1 
    BC067820.1 BC082755.1 BC111493.1 

    13 DOTS entries:

    DT.451335  DT.100820691  DT.92429218  DT.121262194  DT.100820690  DT.102827673  DT.102827674  DT.102827675 
    DT.121262223  DT.121262227  DT.40124998  DT.92414438  DT.95207495 

    24/177 AceView cDNA sequences (see all 177):

    NM_198330 AA430333 AI492073 AI399774 AL137528 AV726030 BU161271 AI762736 
    CB410142 BX279573 AI581376 AI538500 AW771954 BQ722474 BM929496 AL133757 
    F01955 AI927587 AB023183 BC067820 BU165699 BQ937770 AA300509 BU782077 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for INPP5F (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c ^ 18 ^
    SP1:                                                                          -                             -                             -     -     -         
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                  -         
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 19 ^ 20 ^ 21 ^ 22a · 22b
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for INPP5F

    Expression
    for INPP5F gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    INPP5F expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGATTGAGGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    INPP5F expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ progenitor EN7 (Embryonic Progenitor Cell)
    PureStem™ progenitor W10 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See INPP5F Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for INPP5F

    SOURCE GeneReport for Unigene cluster: Hs.369755

    UniProtKB/Swiss-Prot: SAC2_HUMAN, Q9Y2H2
    Tissue specificity: Ubiquitous

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    In Situ
    Assay Products:     
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    Orthologs
    for INPP5F gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for INPP5F gene from 7/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Inpp5f1 , 5 inositol polyphosphate-5-phosphatase F1, 5 86.99(n)1
    90.71(a)1    		   7 (70.32 cM)5
    1014901  NM_178641.51  NP_848756.21 
     1286113285 
    chicken
    (Gallus gallus)    		 Aves INPP5F1 inositol polyphosphate-5-phosphatase F 78.31(n)
    83.69(a)    		   423932  XM_421792.3  XP_421792.2 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 79(a)
    		 1 ↔ 1
    		 3(66204153-66257248)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia 1420155872   -- 73.59(n)    142015587 
    zebrafish
    (Danio rerio)    		 Actinopterygii inpp5f1 inositol polyphosphate-5-phosphatase F 68.35(n)
    73.51(a)    		   570007  NM_001126432.1  NP_001119904.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG79561 CG7956 45.73(n)
    38.69(a)    		   42545  NM_001043275.1  NP_001036740.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea CELE_W09C5.71 Protein W09C5.7 46.12(n)
    36.43(a)    		   173236  NM_060992.3  NP_493393.1 


    ENSEMBL Gene Tree for INPP5F (if available)
    TreeFam Gene Tree for INPP5F (if available) 

    Paralogs
    for INPP5F gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for INPP5F gene
    SACM1L2  

    INPP5F for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for INPP5F
    PGOHUM00000240417


    Genomic Variants
    for INPP5F gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1735 NCBI SNPs in INPP5F are shown (see all 1735)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1137641051,2
    		--121483582(+) TGATGG/ACATTA 2 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1403961181,2
    		C,--121483697(+) ATCTG-/GGGA  
                GCTTA     		2 -- us2k10--------
    rs1890641421,2
    		--121483704(+) GAGCTC/TAGAAA 2 -- us2k10--------
    rs1161391771,2
    		F,--121483799(+) AATTCC/TCCAGG 2 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1928468901,2
    		--121483821(+) GGCAGC/TCAGGG 2 -- us2k10--------
    rs1472951851,2
    		--121483892(+) ACAGTC/TACAAC 2 -- us2k10--------
    rs1962121,2
    		C,F,H,--121484123(+) CACCTC/ACCTCG 2 -- us2k1 tfbs325Minor allele frequency- A:0.36NS EA NA WA CSA 2707
    rs37586151,2
    		C,--121484134(+) ACCTTC/TATGTT 2 -- us2k14Minor allele frequency- T:0.45NA WA EA 360
    rs37586161,2
    		C,F,H,--121484162(+) CAGAGG/ACATGG 2 -- us2k18Minor allele frequency- A:0.02NS EA NA 544
    rs792567891,2
    		--121484237(+) CTGTGG/CGCTGG 2 -- us2k11Minor allele frequency- C:0.01WA 118

    HapMap Linkage Disequilibrium report for INPP5F (121485609 - 121588659 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for INPP5F
         1 Indel: 24346

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    Disorders / Diseases
    for INPP5F gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    INPP5F for disorders           About GeneDecksing

    OMIM gene information: 609389    OMIM disorders: --

    2 diseases for INPP5F:    About MalaCards
    alzheimer's disease    malaria

    Human Genome Epidemiology (HuGE) Navigator: INPP5F (1 document)

    Export disorders for INPP5F gene to outside databases

    Publications
    for INPP5F gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for INPP5F gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with INPP5F)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of a sac domain-containing phosphoinositide 5-phosphatase. (PubMed id 11274189)1, 2, 3, 9 Minagawa T.... Takenawa T. (2001)
    2. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2, 3 Nagase T.... Ohara O. (1999)
    3. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    4. Inpp5f is a polyphosphoinositide phosphatase that reg ulates cardiac hypertrophic responsiveness. (PubMed id 19875726)1 Zhu W....Epstein J.A. (2009)
    5. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    6. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    7. Root hair defective4 encodes a phosphatidylinositol-4-phosphate phosphatase required for proper root hair development in Arabidopsis thaliana. (PubMed id 18281508)1 Thole J.M....Nielsen E. (2008)
    8. Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity. (PubMed id 17322895)2 Trivedi C.M.... Epstein J.A. (2007)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    10. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1 Grupe A....Goate A. (2006)

    External Searches for INPP5F gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing INPP5F gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22876 HGNC: 17054 AceView: INPP5F Ensembl:ENSG00000198825 euGenes: HUgn22876
    ECgene: INPP5F H-InvDB: INPP5F

    Other Databases showing INPP5F gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0966

    Specialized Databases showing INPP5F gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for INPP5F Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for INPP5F gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for INPP5F gene:
    Search GeneIP for patents involving INPP5F

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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