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INPP5D Gene

protein-coding   GIFtS: 70
GCID: GC02P233924

Inositol Polyphosphate-5-Phosphatase, 145kDa

(Previous names: inositol polyphosphate-5-phosphatase, 145kD)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Inositol Polyphosphate-5-Phosphatase, 145kDa1 2     Phosphatidylinositol 3,4,5-Trisphosphate 5-Phosphatase 12
SHIP2 3 5     Signaling Inositol Polyphosphate 5 Phosphatase SIP-1452
SHIP-12 3     Signaling Inositol Polyphosphate Phosphatase SHIP II2
SHIP12 3     EC 3.1.3.863
SIP-1452 3     Inositol Polyphosphate-5-Phosphatase Of 145 KDa3
hp51CN2 3     SH2 Domain-Containing Inositol Phosphatase 13
p150Ship2 3     EC 3.1.38
SH2 Domain-Containing Inositol 5'-Phosphatase 12 3     EC 3.1.3.n18
Inositol Polyphosphate-5-Phosphatase, 145kD1     

External Ids:    HGNC: 60791   Entrez Gene: 36352   Ensembl: ENSG000001689187   OMIM: 6015825   UniProtKB: Q928353   

Export aliases for INPP5D gene to outside databases

Previous GC identifers: GC02P232000 GC02P232751 GC02P234086 GC02P234127 GC02P233851 GC02P233633 GC02P225771


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for INPP5D Gene:
This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an
N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression
of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane
is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from
phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple
signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear
inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell
proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system.
Alternative splicing of this gene results in multiple transcript variants. (provided by RefSeq, Feb 2014)

GeneCards Summary for INPP5D Gene:
INPP5D (inositol polyphosphate-5-phosphatase, 145kDa) is a protein-coding gene. GO annotations related to this gene include SH3 domain binding and PTB domain binding. An important paralog of this gene is INPP5E.

UniProtKB/Swiss-Prot: SHIP1_HUMAN, Q92835
Function: Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of
phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively
regulating the PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor
signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating
signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of
myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin
alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast
precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved
in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase
C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and
polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the
activin/TGF-beta-induced apoptosis through its Smad-dependent expression. May also hydrolyze PtdIns(1,3,4,5)P4,
and could thus affect the levels of the higher inositol polyphosphates like InsP6

Gene Wiki entry for INPP5D Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the INPP5D gene promoter:
         AP-1   Pax-5   ATF-2   Egr-1   HSF1 (long)   Nkx5-1   YY1   Evi-1   HSF2   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidINPP5D promoter sequence
   Search Chromatin IP Primers for INPP5D

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat INPP5D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.1   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37.1

INPP5D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INPP5D gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P233924:  view genomic region     (about GC identifiers)

Start:
233,924,677 bp from pter      End:
234,116,549 bp from pter
Size:
191,873 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SHIP1_HUMAN, Q92835 (See protein sequence)
Recommended Name: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1  
Size: 1189 amino acids; 133292 Da
Subunit: Interacts with tyrosine phosphorylated forms of SHC1, DOK1, DOK3, PTPN11/SHP-2, SLAMF1/CD150. Interacts
with PTPN11 in response to IL-3. Interacts with receptors EPOR, MS4A2/FCER1B and FCER1G, FCGR2A, FCGR2B and
FCGR3. Interacts with GRB2 and PLCG1. Interacts with tyrosine kinases SRC and TEC. Interacts with FCGR2A, leading
to regulate gene expression during the phagocytic process. Interacts with c-Met/MET (By similarity). Interacts
with MILR1 (tyrosine-phosphorylated). Can weakly interact (via NPXY motif 2) with DAB2 (via PID domain); the
interaction is impaired by tyrosine phosphorylation of the NPXY motif (By similarity)
Sequence caution: Sequence=AAC50454.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for INPP5D:
2YSX (3D)    
Secondary accessions: O00145 Q13544 Q13545 Q6P5A4 Q92656 Q9UE80
Alternative splicing: 3 isoforms:  Q92835-1   Q92835-2   Q92835-3   

Explore the universe of human proteins at neXtProt for INPP5D: NX_Q92835

Explore proteomics data for INPP5D at MOPED

Post-translational modifications: 

  • Tyrosine phosphorylated by the members of the SRC family after exposure to a diverse array of extracellular
    stimuli such as cytokines, growth factors, antibodies, chemokines, integrin ligands and hypertonic and oxidative
    stress. Phosphorylated upon IgG receptor FCGR2B-binding1
  • Ubiquitination2 at Lys365
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for INPP5D (Q92835) (see all 15)
     RFTHLFW  IPHDIYV  VESGKLI  TSDHSPVF 


    See INPP5D Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001017915.1  NP_005532.2  

    ENSEMBL proteins: 
     ENSP00000409018   ENSP00000415253   ENSP00000400151   ENSP00000397421   ENSP00000405338  
     ENSP00000414835   ENSP00000473280   ENSP00000352575   ENSP00000441010   ENSP00000407916  
     ENSP00000404610  
    Reactome Protein details: Q92835

    INPP5D Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for INPP5D

     
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    antibodies-online peptides for INPP5D

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    antibodies-online antibodies for INPP5D (90 products) 

    INPP5D Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SH2D: SH2 domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: INPP5D
    Inositol polyphosphate phosphatases

    3 InterPro protein domains:
     IPR000300 IPPc
     IPR005135 Endo/exonuclease/phosphatase
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry Q92835

    ProtoNet protein and cluster: Q92835

    2 Blocks protein domains:
    IPB000300 Inositol polyphosphate related phosphatase family
    IPB000980 SH2 domain signature


    UniProtKB/Swiss-Prot: SHIP1_HUMAN, Q92835
    Domain: The SH2 domain interacts with tyrosine phosphorylated forms of proteins such as SHC1 or PTPN11/SHP-2. It
    competes with that of GRB2 for binding to phosphorylated SHC1 to inhibit the Ras pathway. It is also required for
    tyrosine phosphorylation (By similarity)
    Domain: The NPXY sequence motif found in many tyrosine-phosphorylated proteins is required for the specific
    binding of the PID domain (By similarity)
    Similarity: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family
    Similarity: Contains 1 SH2 domain


    Find genes that share domains with INPP5D           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SHIP1_HUMAN, Q92835
    Function: Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of
    phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively
    regulating the PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor
    signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating
    signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of
    myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin
    alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast
    precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved
    in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase
    C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and
    polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the
    activin/TGF-beta-induced apoptosis through its Smad-dependent expression. May also hydrolyze PtdIns(1,3,4,5)P4,
    and could thus affect the levels of the higher inositol polyphosphates like InsP6
    Catalytic activity: 1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol
    3,4-diphosphate + phosphate
    Enzyme regulation: Activated upon translocation to the sites of synthesis of PtdIns(3,4,5)P3 in the membrane (By
    similarity)

         Genatlas biochemistry entry for INPP5D:
    inositol 1,4,5-triphosphate-5 phosphatase (145kDa),expressed in bone marrow in B and T cells and various
    tissues,interacting with phosphotyrosine inhibitory motif of Fcgamma RIIB (FCGR2B) for negative regulation of the
    immune receptor activation in both B and mast cells,down-regulating cytokine receptor signaling in myeloid
    cells,inhibiting ras signaling by competing with GRB2,signal terminating reaction in the inositol signaling
    pathway,negative regulator of lymphocyte activation

         Enzyme Numbers (IUBMB): EC 3.1.32 EC 3.1.3.n12 EC 3.1.3.861

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004445inositol-polyphosphate 5-phosphatase activity IEA--
    GO:0005515protein binding IPI10382761
    GO:0017124SH3 domain binding IEA--
    GO:0034594phosphatidylinositol trisphosphate phosphatase activity IEA--
    GO:0051425PTB domain binding IEA--
         
    Find genes that share ontologies with INPP5D           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for INPP5D:
     Increased circadian rhythm amp 

         14 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Inpp5d):
     behavior/neurological  cellular  digestive/alimentary  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  integument  limbs/digits/tail  mortality/aging 
     muscle  respiratory system  skeleton  tumorigenesis 

    Find genes that share phenotypes with INPP5D           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for INPP5D: Inpp5dtm1Dmt Inpp5dtm1Rkh Inpp5dtm1.1Wgk Inpp5dtm1.1Rav

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for INPP5D
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for INPP5D
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for INPP5D

    miRNA
    Products:
        
    miRTarBase miRNAs that target INPP5D:
    hsa-mir-26b-5p (MIRT030268), hsa-mir-155-5p (MIRT000631), hsa-mir-93-3p (MIRT038735)

    Block miRNA regulation of human, mouse, rat INPP5D using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate INPP5D:
    hsa-miR-124 hsa-miR-539 hsa-miR-342-5p hsa-miR-155 hsa-miR-506 hsa-miR-765 hsa-miR-624* hsa-miR-3144-5p
    SwitchGear 3'UTR luciferase reporter plasmidINPP5D 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SHIP1_HUMAN, Q92835: Cytoplasm. Membrane; Peripheral membrane protein. Note=Translocates to the plasma membrane
    when activated, translocation is probably due to different mechanisms depending on the stimulus and cell type.
    Partly translocated via its SH2 domain which mediates interaction with tyrosine phosphorylated receptors such as
    the FC-gamma-RIIB receptor (FCGR2B) or CD16/FCGR3. Tyrosine phosphorylation may also participate in membrane
    localization (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    plasma membrane2
    cytoskeleton1
    extracellular1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0016020membrane IEA--

    Find genes that share ontologies with INPP5D           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for INPP5D About   (see all 27)  
    See pathways by source

    SuperPathContained pathways About
    1Inositol phosphate metabolism (KEGG)
    Inositol phosphate metabolism0.61
    superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism0.00
    Phosphatidylinositol signaling system0.61
    D-myo-inositol (1,3,4)-trisphosphate biosynthesis0.00
    superpathway of inositol phosphate compounds0.60
    1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)0.00
    2Immune response Fc epsilon RI pathway
    Immune response BCR pathway0.43
    Fc epsilon RI signaling pathway0.41
    3Signaling by Interleukins
    Interleukin receptor SHC signaling0.67
    Interleukin-3, 5 and GM-CSF signaling0.59
    Interleukin-2 signaling0.67
    Signaling by Interleukins0.42
    4TCR signaling (REACTOME)
    Downstream TCR signaling0.73
    TCR signaling0.73
    5PI Metabolism
    PI Metabolism0.65
    Synthesis of PIPs at the plasma membrane0.65


    Find genes that share SuperPaths with INPP5D           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for INPP5D
        Phosphatases
    Lymphocyte Signaling

    Selected GeneGo (Thomson Reuters) Pathways for INPP5D (see all 6)
        Immune response IL-4 signaling pathway
    Development EPO-induced MAPK pathway
    Immune response IL-3 activation and signaling pathway
    Immune response CD16 signaling in NK cells
    Immune response BCR pathway

    Selected BioSystems Pathways for INPP5D (see all 10)
        IL-4 signaling Pathway
    Kit Receptor Signaling Pathway
    IL-6 Signaling Pathway
    B Cell Receptor Signaling Pathway
    IL-3 Signaling Pathway

    5 Reactome Pathways for INPP5D
        Interleukin receptor SHC signaling
    Synthesis of PIPs at the plasma membrane
    Downstream TCR signaling
    PECAM1 interactions
    Synthesis of IP3 and IP4 in the cytosol


    5 Kegg Pathways  (Kegg details for INPP5D):
        Inositol phosphate metabolism
    Phosphatidylinositol signaling system
    B cell receptor signaling pathway
    Fc epsilon RI signaling pathway
    Fc gamma R-mediated phagocytosis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for INPP5D
    Interactions:

        GeneGlobe Interaction Network for INPP5D

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for INPP5D (Q928351, 2, 3 ENSP000003525754) via UniProtKB, MINT, STRING, and/or I2D (see all 170)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SH3KBP1Q96B971, 2, 3, ENSP000003809214EBI-1380477,EBI-346595 MINT-8109946 MINT-8109907 MINT-8109894 MINT-8109961 MINT-8109985 MINT-8109933 I2D: score=1 STRING: ENSP00000380921
    FCGR2BP319941, 2, 3, ENSP000003514974EBI-1380477,EBI-724784 MINT-8025723 MINT-74920 I2D: score=2 STRING: ENSP00000351497
    SLAMF1Q132912, 3, ENSP000003061904MINT-8031724 MINT-8031739 I2D: score=2 STRING: ENSP00000306190
    TNFRSF1AP194382, 3, ENSP000001627494MINT-8026316 I2D: score=1 STRING: ENSP00000162749
    SHC1P293532, 3, ENSP000004013034MINT-16179 I2D: score=5 STRING: ENSP00000401303
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 29):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006644phospholipid metabolic process TAS--
    GO:0006661phosphatidylinositol biosynthetic process TAS--
    GO:0006796phosphate-containing compound metabolic process TAS8769125
    GO:0006915apoptotic process IEA--
    GO:0007165signal transduction TAS8769125

    Find genes that share ontologies with INPP5D           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for INPP5D (SHIP1)

    Selected HMDB Compounds for INPP5D (see all 380)    About this table
    CompoundSynonyms CAS #PubMed Ids
    PI(16:0/16:0)Phosphatidylinositol(32:0) (see all 8)----
    PI(16:0/16:1(9Z))Phosphatidylinositol(32:1) (see all 14)----
    PI(16:0/16:2(9Z,12Z))Phosphatidylinositol(16:0/16:2n4) (see all 18)----
    PI(16:0/18:0)Phosphatidylinositol(16:0/18:0) (see all 8)----
    PI(16:0/18:1(11Z))Phosphatidylinositol(16:0/18:1w7) (see all 14)----
    PI(16:0/18:1(9Z))Phosphatidylinositol(16:0/18:1) (see all 14)----
    PI(16:0/18:2(9Z,12Z))PIno(16:0/18:2) (see all 14)----
    PI(16:0/20:0)PI(16:0/20:0) (see all 8)----
    PI(16:0/20:2(11Z,14Z))Phosphatidylinositol(16:0/20:2n6) (see all 14)----
    PI(16:0/20:3(5Z,8Z,11Z))Phosphatidylinositol(36:3) (see all 14)----

    Selected Novoseek inferred chemical compound relationships for INPP5D gene (see all 17)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inositol 92.9 175 16000869 (3), 9099679 (2), 19494109 (2), 10623804 (2) (see all 99)
    phosphatidylinositol-3,4,5-trisphosphate 88.8 21 12885297 (4), 10570274 (1), 10623804 (1), 10942391 (1) (see all 14)
    tyrosine 74.3 138 10570274 (5), 10352260 (4), 20304029 (4), 9341117 (4) (see all 62)
    phosphatidylinositol 72.9 44 17442886 (2), 15457186 (2), 11713294 (2), 10194437 (1) (see all 22)
    phosphoinositide 63.5 8 10066815 (2), 15701712 (1), 19703514 (1), 15990278 (1) (see all 5)
    phosphotyrosine 62.7 9 10623804 (2), 9099679 (1), 10395202 (1), 15470047 (1) (see all 5)
    inositol 1,3,4,5-tetrakisphosphate 56.1 2 9341117 (1), 10610720 (1)
    ly294002 30.8 1 15701712 (1)
    histamine 30.3 6 11692111 (2), 18042794 (1), 17336612 (1), 12217402 (1)
    serine 27.6 1 10229804 (1)



    Find genes that share compounds with INPP5D           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for INPP5D gene (2 alternative transcripts): 
    NM_001017915.2  NM_005541.4  

    Unigene Clusters for INPP5D:

    Inositol polyphosphate-5-phosphatase, 145kDa
    Hs.262886  [show with all ESTs], Hs.601911  [show with all ESTs]
    Unigene Representative Sequences: U50040, U57650
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000422935 ENST00000451407 ENST00000467393 ENST00000474278 ENST00000496402
    ENST00000435188 ENST00000415617 ENST00000445964 ENST00000493078 ENST00000472517
    ENST00000493632 ENST00000480983 ENST00000465281 ENST00000417661 ENST00000491070
    ENST00000359570(uc010zmo.2 uc010zmp.2) ENST00000538935 ENST00000450745

    miRNA
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    hsa-miR-124 hsa-miR-539 hsa-miR-342-5p hsa-miR-155 hsa-miR-506 hsa-miR-765 hsa-miR-624* hsa-miR-3144-5p
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    Additional mRNA sequence: 

    AK298651.1 AK309644.1 AK311547.1 BC027960.1 BC099920.1 BC113580.1 BC113582.1 U50041.1 
    U53470.1 U57650.1 U84400.1 X98429.1 

    19 DOTS entries:

    DT.451961  DT.99934945  DT.100776485  DT.40309482  DT.318477  DT.92058107  DT.40117378  DT.91684713 
    DT.100741813  DT.95221780  DT.95360361  DT.100776486  DT.101976185  DT.120998804  DT.120998825  DT.92437626 
    DT.95346586  DT.95360378  DT.97846612 

    Selected AceView cDNA sequences (see all 349):

    AI961731 AW515861 AI159831 BM711995 BQ709268 AA769355 AI350711 AI423811 
    AI453540 AI472151 CF136498 BE858322 CK429637 BF445264 AW402645 BI911156 
    AI684845 AI523565 BQ771578 AW005263 AA713684 BQ637530 AI424492 H00608 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for INPP5D (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
    SP1:        -                 -           -                                                                                   -     -               
    SP2:                                                                                                                                                
    SP3:                                                                                                                    -     -     -               
    SP4:                                      -                                                                                                         
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for INPP5D

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    INPP5D expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGAAGTCT
    INPP5D Expression
    About this image


    INPP5D expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Spleen (Hematopoietic System)
    INPP5D Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    INPP5D Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.262886 Hs.601911

    UniProtKB/Swiss-Prot: SHIP1_HUMAN, Q92835
    Tissue specificity: Specifically expressed in immune and hematopoietic cells. Expressed in bone marrow and blood
    cells. Levels vary considerably within this compartment. Present in at least 74% of immature CD34+ cells, whereas
    within the more mature population of CD33+ cells, it is present in only 10% of cells. Present in the majority of
    T-cells, while it is present in a minority of B-cells (at protein level)

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for INPP5D gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Inpp5d1 , 5 inositol polyphosphate-5-phosphatase D1, 5 85.25(n)1
    88.41(a)1
      1 (44.44 cM)5
    163311  NM_010566.21  NP_034696.21 
     876203125 
    chicken
    (Gallus gallus)
    Aves INPP5D1 inositol polyphosphate-5-phosphatase, 145kDa 70.76(n)
    69.93(a)
      424745  XM_004936934.1  XP_004936991.1 
    lizard
    (Anolis carolinensis)
    Reptilia INPP5D6
    inositol polyphosphate-5-phosphatase, 145kDa
    64(a)
    1 ↔ 1
    3(35819054-35910910)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC689932 hypothetical protein MGC68993 75.75(n)    BC063273.1 
    zebrafish
    (Danio rerio)
    Actinopterygii inpp5d1 inositol polyphosphate-5-phosphatase, 145kDa 61.59(n)
    61.99(a)
      559103  XM_001922972.3  XP_001923007.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ocrl6
    Oculocerebrorenal syndrome of Lowe 1 ortholog
    17(a)
    1 → many
    X(1817014-1821557)
    worm
    (Caenorhabditis elegans)
    Secernentea ocrl-16
    Protein OCRL-1, isoform a
    20(a)
    1 → many
    I(9715322-9728108) WBGene00007620


    ENSEMBL Gene Tree for INPP5D (if available)
    TreeFam Gene Tree for INPP5D (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for INPP5D gene
    INPP5E2  INPPL12  INPP5B2  INPP5J2  SYNJ12  OCRL2  INPP5K2  SYNJ22  
    3 SIMAP similar genes for INPP5D using alignment to 9 protein entries:     SHIP1_HUMAN (see all proteins):
    SH2D1A    INPPL1    SH2D1B

    Find genes that share paralogs with INPP5D           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    2 SNPs for INPP5D    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs92471,2,4
    ----see VAR_0593582 mis40--------
    VAR_0349794
    ----see VAR_0349792 V E mis40--------

    HapMap Linkage Disequilibrium report for INPP5D (233924677 - 234116549 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for INPP5D:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1142800CNV Deletion17803354
    esv2657351CNV Deletion23128226
    esv2721651CNV Deletion23290073
    esv1209599CNV Deletion17803354
    nsv3213CNV Insertion18451855
    nsv520361CNV Loss19592680
    nsv527354CNV Gain19592680
    nsv876009CNV Gain21882294
    nsv876012CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601582    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for INPP5D:
    Oculocerebrorenal syndrome

    Find genes that share disorders with INPP5D           About GenesLikeMe

    Selected Novoseek inferred disease relationships for INPP5D gene (see all 17)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemogenesis 54.4 6 12829595 (1), 15363123 (1), 15355687 (1), 12149650 (1) (see all 5)
    lymphoproliferative syndrome 43.3 3 11313386 (1), 10229804 (1)
    erythroleukemia 30.2 2 10597315 (1)
    myeloid leukemia 13.3 1 12529653 (1)
    myeloproliferative disorders 13 4 15457186 (1), 17268534 (1)
    lymphoma 12.8 3 19890474 (2), 12885297 (1)
    burkitt lymphoma 10.7 1 10382761 (1)
    acute leukemia 9.65 6 15363123 (2), 15355687 (2)
    myeloid leukemia chronic 7.98 1 12829595 (1)
    leukemia 6.69 14 15457186 (3), 19377826 (3), 16351639 (2), 19622295 (2) (see all 5)

    Genetic Association Database (GAD): INPP5D
    Human Genome Epidemiology (HuGE) Navigator: INPP5D (5 documents)

    Export disorders for INPP5D gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for INPP5D gene, integrated from 10 sources (see all 263):
    (articles sorted by number of sources associating them with INPP5D)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of human SHIP, the 145-kD inositol 5- phosphatase that associates with SHC after cytokine stimulation. (PubMed id 8874179)1, 2, 3, 9 Ware M.D.... Krystal G. (Blood 1996)
    2. The human SHIP gene is differentially expressed in cell lineages of the bone marrow and blood. (PubMed id 9058707)1, 2, 9 Geier S.J.... Rohrschneider L.R. (Blood 1997)
    3. The Src homology 2-containing inositol 5-phosphatase 1 (SHIP1) is involved in CD32a signaling in human neutrophils. (PubMed id 16682172)1, 2, 9 Vaillancourt M.... Naccache P.H. (Cell. Signal. 2006)
    4. The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells. (PubMed id 10822173)1, 2, 9 Dunant N.M.... Resh M.D. (Cell. Signal. 2000)
    5. CDw150 associates with src-homology 2-containing inositol phosphatase and modulates CD95-mediated apoptosis. (PubMed id 10229804)1, 2, 9 Mikhalap S.V....Sidorenko S.P. (J. Immunol. 1999)
    6. Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2. (PubMed id 8723348)1, 2, 9 Kavanaugh W.M....Williams L.T. (Curr. Biol. 1996)
    7. Evidence that SHIP-1 contributes to phosphatidylinositol 3,4,5- trisphosphate metabolism in T lymphocytes and can regulate novel phosphoinositide 3-kinase effectors. (PubMed id 12421919)1, 2, 9 Freeburn R.W....Ward S.G. (J. Immunol. 2002)
    8. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. (PubMed id 21378990)1, 4 Schunkert H....Samani N.J. (Nat. Genet. 2011)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    10. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (J. Infect. Dis. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3635 HGNC: 6079 AceView: INPP5D Ensembl:ENSG00000168918 euGenes: HUgn3635
    ECgene: INPP5D Kegg: 3635 H-InvDB: INPP5D

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for INPP5D Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for INPP5D Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for INPP5D gene:
    Search GeneIP for patents involving INPP5D

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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