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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

INPP5D Gene

protein-coding   GIFtS: 67
GCID: GC02P233924

inositol polyphosphate-5-phosphatase, 145kDa

(Previous names: inositol polyphosphate-5-phosphatase, 145kD )
 Explore 28 diseases affiliated with
INPP5D via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for INPP5D    

Aliases
for INPP5D gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Inositol Polyphosphate-5-Phosphatase, 145kDa1 2     Inositol Polyphosphate-5-Phosphatase, 145kD1
SHIP1 2 3 5     Phosphatidylinositol 3,4,5-Trisphosphate 5-Phosphatase 12
Hp51CN1     Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatase 12
Inositol Polyphosphate-5-Phosphatase Of 145 KDa2 3     SH2 Containing Inositol Phosphatase2
SHIP-12 3     SH2 Domain-Containing Inositol-5'-Phosphatase 12
SHIP12 3     Signaling Inositol Polyphosphate 5 Phosphatase SIP-1452
SIP-1452 3     EC 3.1.3.863
P150Ship1     EC 3.1.38
SH2 Domain-Containing Inositol 5'-Phosphatase 12 3     EC 3.1.3.N11
SH2 Domain-Containing Inositol Phosphatase 12 3     

External Ids:    HGNC: 60791   Entrez Gene: 36352   Ensembl: ENSG000001689187   OMIM: 6015825   UniProtKB: Q928353   

Export aliases for INPP5D gene to outside databases

Previous GC identifers: GC02P232000 GC02P232751 GC02P234086 GC02P234127 GC02P233851 GC02P233633 GC02P225771


Summaries
for INPP5D gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for INPP5D:
This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an
N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of
this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is
mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from
phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple
signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival.
Alternate transcriptional splice variants, encoding different isoforms, have been characterized. (provided by RefSeq,
Jul 2008)

UniProtKB/Swiss-Prot: SHIP1_HUMAN, Q92835
Function: Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of
phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the
PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates
signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from
activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell
proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3
signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage
programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell
junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of
neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis.
Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its
Smad-dependent expression. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher
inositol polyphosphates like InsP6

Gene Wiki entry for INPP5D


Genomic Views
for INPP5D gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005120.16  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the INPP5D gene promoter:
         AP-1   Pax-5   ATF-2   Egr-1   HSF1 (long)   Nkx5-1   YY1   Evi-1   HSF2   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: INPP5D promoter sequence
   Search SABiosciences Chromatin IP Primers for INPP5D

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INPP5D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.1   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37.1

INPP5D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INPP5D gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P233924:  view genomic region     (about GC identifiers)

Start:
 233,924,677 bp from pter      End:
 234,116,549 bp from pter
Size:
 191,873 bases      Orientation:
 plus strand

Proteins
for INPP5D gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SHIP1_HUMAN, Q92835 (See protein sequence)
Recommended Name: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1  
Size: 1189 amino acids; 133292 Da
Subunit: Interacts with tyrosine phosphorylated forms of SHC1, DOK1, DOK3, PTPN11/SHP-2, SLAMF1/CD150. Interacts with
PTPN11 in response to IL-3. Interacts with receptors EPOR, MS4A2/FCER1B and FCER1G, FCGR2A, FCGR2B and FCGR3.
Interacts with GRB2 and PLCG1. Interacts with tyrosine kinases SRC and TEC. Interacts with FCGR2A, leading to regulate
gene expression during the phagocytic process. Interacts with c-Met/MET (By similarity). Interacts with MILR1
(tyrosine-phosphorylated). Can weakly interact (via NPXY motif 2) with DAB2 (via PID domain); the interaction is
impaired by tyrosine phosphorylation of the NPXY motif (By similarity)
Subcellular location: Cytoplasm. Membrane; Peripheral membrane protein. Note=Translocates to the plasma membrane when
activated, translocation is probably due to different mechanisms depending on the stimulus and cell type. Partly
translocated via its SH2 domain which mediates interaction with tyrosine phosphorylated receptors such as the
FC-gamma-RIIB receptor (FCGR2B) or CD16/FCGR3. Tyrosine phosphorylation may also participate in membrane localization
(By similarity)
Sequence caution: Sequence=AAC50454.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for INPP5D:
2YSX (3D)    
Secondary accessions: O00145 Q13544 Q13545 Q6P5A4 Q92656 Q9UE80
Alternative splicing: 3 isoforms:  Q92835-1   Q92835-2   Q92835-3   

Explore the universe of human proteins at neXtProt for INPP5D: NX_Q92835

Post-translational modifications:

  • Tyrosine phosphorylated by the members of the SRC family after exposure to a diverse array of extracellular stimuli
    • such as cytokines, growth factors, antibodies, chemokines, integrin ligands and hypertonic and oxidative stress.
    Phosphorylated upon IgG receptor FCGR2B-binding1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q92835

    • 4/15 DME Specific Peptides for INPP5D (Q92835) (see all 15)
     VESGKLI  IPHDIYV  RFTHLFW  TSDHSPVF 

    INPP5D Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001017915.1  NP_005532.2  

    ENSEMBL proteins: 
     ENSP00000409018   ENSP00000415253   ENSP00000400151   ENSP00000397421   ENSP00000405338  
     ENSP00000414835   ENSP00000352575   ENSP00000441010   ENSP00000407916   ENSP00000404610  
    Reactome Protein details: Q92835
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: INPP5D
    OriGene Protein Over-expression Lysate: INPP5D
    OriGene Custom Protein Services for INPP5D 
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    Novus Biologicals INPP5D Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for INPP5D

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005625soluble fraction ----
    GO:0005829cytosol TAS--
    GO:0005884actin filament ----
    GO:0005886plasma membrane ----


    INPP5D for ontologies           About GeneDecksing



    INPP5D Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of INPP5D
    R&D Systems Antibodies for INPP5D (SHIP)
    Cell Signaling Technology (CST) Antibodies for INPP5D  (SHIP)
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    ThermoFisher Antibody for INPP5D

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    Uscn ELISAs and CLIAs for INPP5D

    Protein Domains /
    Families
    for INPP5D gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    INPP5D for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR005135 Endo/exonuclease/phosphatase
     IPR000300 IPPc
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry Q92835

    ProtoNet protein and cluster: Q92835

    2 Blocks protein families:
    IPB000300 Inositol polyphosphate related phosphatase family
    IPB000980 SH2 domain signature


    UniProtKB/Swiss-Prot: SHIP1_HUMAN, Q92835
    Domain: The SH2 domain interacts with tyrosine phosphorylated forms of proteins such as SHC1 or PTPN11/SHP-2. It
    competes with that of GRB2 for binding to phosphorylated SHC1 to inhibit the Ras pathway. It is also required for
    tyrosine phosphorylation (By similarity)
    Domain: The NPXY sequence motif found in many tyrosine-phosphorylated proteins is required for the specific binding of
    the PID domain (By similarity)
    Similarity: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family
    Similarity: Contains 1 SH2 domain


    Function
    for INPP5D gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SHIP1_HUMAN, Q92835
    Function: Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of
    phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the
    PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates
    signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from
    activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell
    proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3
    signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage
    programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell
    junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of
    neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis.
    Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its
    Smad-dependent expression. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher
    inositol polyphosphates like InsP6
    Catalytic activity: 1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol
    3,4-diphosphate + phosphate
    Enzyme regulation: Activated upon translocation to the sites of synthesis of PtdIns(3,4,5)P3 in the membrane (By
    similarity)

         Genatlas biochemistry entry for INPP5D:
    inositol 1,4,5-triphosphate-5 phosphatase (145kDa),expressed in bone marrow in B and T cells and various
    tissues,interacting with phosphotyrosine inhibitory motif of Fcgamma RIIB (FCGR2B) for negative regulation of the
    immune receptor activation in both B and mast cells,down-regulating cytokine receptor signaling in myeloid
    cells,inhibiting ras signaling by competing with GRB2,signal terminating reaction in the inositol signaling
    pathway,negative regulator of lymphocyte activation

    Enzyme Numbers (IUBMB): EC 3.1.32 EC 3.1.3.n12 EC 3.1.3.861

    miRNA
    Products:            		miRTarBase miRNAs that target INPP5D:
    hsa-mir-155 (MIRT000631)

    OriGene 3'-UTR Clone (see all 2): INPP5D
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat INPP5D
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate INPP5D:
    hsa-miR-124 hsa-miR-539 hsa-miR-342-5p hsa-miR-155 hsa-miR-506 hsa-miR-765 hsa-miR-624* hsa-miR-3144-5p
    SwitchGear 3'UTR luciferase reporter plasmid: INPP5D 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for INPP5D (see all 7)
    OriGene shRNA RFP: INPP5D
    OriGene siRNA: INPP5D
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat INPP5D

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for INPP5D

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for INPP5D (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for INPP5D (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): INPP5D (NM_001017915)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INPP5D
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INPP5D 

    Cell Line
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    Search LifeMap BioReagents cell lines for INPP5D

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INPP5D

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004445inositol-polyphosphate 5-phosphatase activity IEA--
    GO:0005515protein binding IPI--
    GO:0017124SH3 domain binding IEA--
    GO:0030487inositol-4,5-bisphosphate 5-phosphatase activity ----
    GO:0034594phosphatidylinositol trisphosphate phosphatase activity IEA--


    INPP5D for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for INPP5D:
     Increased circadian rhythm amp 

    Animal Models:
         Mouse knock-outs for INPP5D: Inpp5dtm1Dmt Inpp5dtm1Rkh Inpp5dtm1.1Wgk Inpp5dtm1.1Rav
         14 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Inpp5d):
     behavior/neurological  cellular  digestive/alimentary  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  integument  limbs/digits/tail  mortality/aging 
     muscle  respiratory system  skeleton  tumorigenesis 

    INPP5D for phenotypes           About GeneDecksing


    Pathways & Interactions
    for INPP5D gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/30 super-pathways (see all 30) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Interleukin receptor SHC signaling
    		Interleukin receptor SHC signaling1.00
    		Interleukin-3, 5 and GM-CSF signaling0.57
    		Interleukin-2 signaling0.67
    		Signaling by Interleukins0.25
    2D-myo-inositol (1,3,4)-trisphosphate biosynthesis
    		D-myo-inositol (1,3,4)-trisphosphate biosynthesis1.00
    		superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism0.75
    		1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)0.76
    		3-phosphoinositide degradation0.33
    3Immune response_IL-4 signaling pathway
    		Immune response_IL-4 signaling pathway1.00
    		Immune response IL-4 signaling pathway0.98
    4Immune System
    		Immune System1.00
    		Adaptive Immune System0.59
    5Synthesis of IP3 and IP4 in the cytosol
    		Synthesis of IP3 and IP4 in the cytosol1.00
    		Inositol phosphate metabolism0.57

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/6 EMD Millipore Pathways for INPP5D (see all 6)
        Immune response BCR pathway
    Immune response CD16 signaling in NK cells
    Immune response IL-3 activation and signaling pathway
    Development EPO-induced MAPK pathway
    Immune response IL-4 signaling pathway


    2 Cell Signaling Technology (CST) Pathways for INPP5D
        Phosphatases
    Lymphocyte Signaling

    5/6 GeneGo (Thomson Reuters) Pathways for INPP5D (see all 6)
        Immune response IL-4 signaling pathway
    Development EPO-induced MAPK pathway
    Immune response IL-3 activation and signaling pathway
    Immune response CD16 signaling in NK cells
    Immune response BCR pathway

    5/10 BioSystems Pathways for INPP5D (see all 10) 
        D-myo-inositol (1,3,4)-trisphosphate biosynthesis
    IL-3 Signaling Pathway
    IL-6 Signaling Pathway
    B Cell Receptor Signaling Pathway
    1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)

    5/19        Reactome Pathways for INPP5D (see all 19)
        Metabolism
    Inositol phosphate metabolism
    Interleukin receptor SHC signaling
    PI Metabolism
    Metabolism of lipids and lipoproteins


    5         Kegg Pathways  (Kegg details for INPP5D):
        Phosphatidylinositol signaling system
    B cell receptor signaling pathway
    Fc epsilon RI signaling pathway
    Fc gamma R-mediated phagocytosis
    Insulin signaling pathway


    INPP5D for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for INPP5D

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/152 Interacting proteins for INPP5D (Q928352, 3 ENSP000003525754) via UniProtKB, MINT, STRING, and/or I2D (see all 152)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SH3KBP1Q96B972, 3, ENSP000003809214MINT-8109946 MINT-8109907 MINT-8109894 MINT-8109961 MINT-8109985 MINT-8109933 I2D: score=1 STRING: ENSP00000380921
    FCGR2BP319942, 3, ENSP000003514974MINT-8025723 MINT-74920 I2D: score=2 STRING: ENSP00000351497
    SLAMF1Q132912, 3, ENSP000003061904MINT-8031724 MINT-8031739 I2D: score=2 STRING: ENSP00000306190
    TNFRSF1AP194382, 3, ENSP000001627494MINT-8026316 I2D: score=1 STRING: ENSP00000162749
    SHC1P293532, 3, ENSP000004013034MINT-16179 I2D: score=5 STRING: ENSP00000401303
    About this table

    Gene Ontology (GO): 5/28 biological process terms (GO ID links to tree view) (see all 28):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006644phospholipid metabolic process TAS--
    GO:0006661phosphatidylinositol biosynthetic process TAS--
    GO:0006796phosphate-containing compound metabolic process TAS8769125
    GO:0006915apoptotic process IEA--
    GO:0007165signal transduction TAS8769125


    INPP5D for ontologies           About GeneDecksing



    Drugs & Compounds
    for INPP5D gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    INPP5D for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for INPP5D

    10/380 HMDB Compounds for INPP5D (see all 380)    About this table
    CompoundSynonyms CAS #PubMed Ids
    PI(16:0/16:0)Phosphatidylinositol(32:0) (see all 8)----
    PI(16:0/16:1(9Z))Phosphatidylinositol(32:1) (see all 14)----
    PI(16:0/16:2(9Z,12Z))Phosphatidylinositol(16:0/16:2n4) (see all 18)----
    PI(16:0/18:0)Phosphatidylinositol(16:0/18:0) (see all 8)----
    PI(16:0/18:1(11Z))Phosphatidylinositol(16:0/18:1w7) (see all 14)----
    PI(16:0/18:1(9Z))Phosphatidylinositol(16:0/18:1) (see all 14)----
    PI(16:0/18:2(9Z,12Z))PIno(16:0/18:2) (see all 14)----
    PI(16:0/20:0)PI(16:0/20:0) (see all 8)----
    PI(16:0/20:2(11Z,14Z))Phosphatidylinositol(16:0/20:2n6) (see all 14)----
    PI(16:0/20:3(5Z,8Z,11Z))Phosphatidylinositol(36:3) (see all 14)----
    10/17 Novoseek chemical compound relationships for INPP5D gene (see all 17)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inositol 92.9 175 16000869 (3), 9099679 (2), 19494109 (2), 10623804 (2) (see all 99)
    phosphatidylinositol-3,4,5-trisphosphate 88.8 21 12885297 (4), 10570274 (1), 10623804 (1), 10942391 (1) (see all 14)
    tyrosine 74.3 138 10570274 (5), 10352260 (4), 20304029 (4), 9341117 (4) (see all 62)
    phosphatidylinositol 72.9 44 17442886 (2), 15457186 (2), 11713294 (2), 10194437 (1) (see all 22)
    phosphoinositide 63.5 8 10066815 (2), 15701712 (1), 19703514 (1), 15990278 (1) (see all 5)
    phosphotyrosine 62.7 9 10623804 (2), 9099679 (1), 10395202 (1), 15470047 (1) (see all 5)
    inositol 1,3,4,5-tetrakisphosphate 56.1 2 9341117 (1), 10610720 (1)
    ly294002 30.8 1 15701712 (1)
    histamine 30.3 6 11692111 (2), 18042794 (1), 17336612 (1), 12217402 (1)
    serine 27.6 1 10229804 (1)

    Search CenterWatch for drugs/clinical trials and news about INPP5D / SHIP1 

    Transcripts
    for INPP5D gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for INPP5D gene (2 alternative transcripts): 
    NM_001017915.1  NM_005541.3  

    Unigene Clusters for INPP5D:

    Inositol polyphosphate-5-phosphatase, 145kDa
    Hs.262886  [show with all ESTs], Hs.601911  [show with all ESTs]
    Unigene Representative Sequences: U50040, U57650
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000422935 ENST00000451407 ENST00000467393 ENST00000474278 ENST00000496402
    ENST00000435188 ENST00000415617 ENST00000445964 ENST00000493078 ENST00000472517
    ENST00000493632 ENST00000480983 ENST00000465281 ENST00000417661 ENST00000491070
    ENST00000359570(uc010zmo.2 uc010zmp.2) ENST00000538935 ENST00000450745


    miRNA
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    8 QIAGEN miScript miRNA Assays for microRNAs that regulate INPP5D:
    hsa-miR-124 hsa-miR-539 hsa-miR-342-5p hsa-miR-155 hsa-miR-506 hsa-miR-765 hsa-miR-624* hsa-miR-3144-5p
    SwitchGear 3'UTR luciferase reporter plasmid: INPP5D 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AK298651.1 AK309644.1 AK311547.1 BC027960.1 BC099920.1 BC113580.1 BC113582.1 U50041.1 
    U53470.1 U57650.1 U84400.1 X98429.1 

    19 DOTS entries:

    DT.451961  DT.99934945  DT.100776485  DT.40309482  DT.318477  DT.92058107  DT.40117378  DT.91684713 
    DT.100741813  DT.95221780  DT.95360361  DT.100776486  DT.101976185  DT.120998804  DT.120998825  DT.92437626 
    DT.95346586  DT.95360378  DT.97846612 

    24/349 AceView cDNA sequences (see all 349):

    AA713684 AI472151 AI141456 AI453540 CK429637 AI350711 BM711995 BE858322 
    AW515861 BU431725 AW503571 AW402645 BQ771578 AI343696 AI424492 BQ709268 
    BF445264 AW139494 AW575201 BM675944 AI423811 CF136498 BI911156 AI913818 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for INPP5D (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
    SP1:        -                 -           -                                                                                   -     -               
    SP2:                                                                                                                                                
    SP3:                                                                                                                    -     -     -               
    SP4:                                      -                                                                                                         
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for INPP5D

    Expression
    for INPP5D gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    INPP5D expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATGGAAGTCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    INPP5D expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)Endothelium
    PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)Endothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See INPP5D Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for INPP5D

    SOURCE GeneReport for Unigene clusters: Hs.262886 Hs.601911

    UniProtKB/Swiss-Prot: SHIP1_HUMAN, Q92835
    Tissue specificity: Specifically expressed in immune and hematopoietic cells. Expressed in bone marrow and blood cells.
    Levels vary considerably within this compartment. Present in at least 74% of immature CD34+ cells, whereas within the
    more mature population of CD33+ cells, it is present in only 10% of cells. Present in the majority of T-cells, while
    it is present in a minority of B-cells (at protein level)

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    In Situ
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    Orthologs
    for INPP5D gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for INPP5D gene from 4/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves INPP5D1 inositol polyphosphate-5-phosphatase, 145kDa 70.84(n)
    70.27(a)    		   424745  XM_422567.3  XP_422567.3 
    lizard
    (Anolis carolinensis)    		 Reptilia INPP5D6
    		 --
    		 65(a)
    		 1 ↔ 1
    		 3(35819707-35907612)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC689932 hypothetical protein MGC68993 75.75(n)    BC063273.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii inpp5d1 inositol polyphosphate-5-phosphatase, 145kDa 61.67(n)
    62.44(a)    		   559103  XM_001922972.2  XP_001923007.2 


    ENSEMBL Gene Tree for INPP5D (if available)
    TreeFam Gene Tree for INPP5D (if available) 

    Paralogs
    for INPP5D gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for INPP5D gene
    INPP5B2  INPP5J2  SYNJ12  OCRL2  INPP5K2  INPP5E2  INPPL12  SYNJ22  
    3 SIMAP similar genes for INPP5D using alignment to 8 protein entries:     SHIP1_HUMAN (see all proteins):
    SH2D1A    INPPL1    SH2D1B

    INPP5D for paralogs           About GeneDecksing



    Genomic Variants
    for INPP5D gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for INPP5D
         1 Indel: 26592
    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for INPP5D gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    INPP5D for disorders           About GeneDecksing

    OMIM gene information: 601582    OMIM disorders: --

    20/28 diseases for INPP5D (see all 28):    About MalaCards
    wiskott-aldrich syndrome    severe congenital neutropenia    juvenile myelomonocytic leukemia    myeloid leukemia
    glucose intolerance    myelomonocytic leukemia    myeloproliferative disorder    burkitt's lymphoma
    b-cell lymphomas    lymphoproliferative syndrome    oculocerebrorenal syndrome    urticaria
    leukemia    chronic myeloid leukemia    acute myeloid leukemia    lymphoblastic leukemia
    neutropenia    acute leukemia    multiple myeloma    myeloma

    1 disease from the University of Copenhagen DISEASES database for INPP5D:
    Oculocerebrorenal syndrome

    10/17 Novoseek disease relationships for INPP5D gene (see all 17)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemogenesis 54.4 6 12829595 (1), 15363123 (1), 15355687 (1), 12149650 (1) (see all 5)
    lymphoproliferative syndrome 43.3 3 11313386 (1), 10229804 (1)
    erythroleukemia 30.2 2 10597315 (1)
    myeloid leukemia 13.3 1 12529653 (1)
    myeloproliferative disorders 13 4 15457186 (1), 17268534 (1)
    lymphoma 12.8 3 19890474 (2), 12885297 (1)
    burkitt lymphoma 10.7 1 10382761 (1)
    acute leukemia 9.65 6 15363123 (2), 15355687 (2)
    myeloid leukemia chronic 7.98 1 12829595 (1)
    leukemia 6.69 14 15457186 (3), 19377826 (3), 16351639 (2), 19622295 (2) (see all 5)

    Human Genome Epidemiology (HuGE) Navigator: INPP5D (5 documents)

    Export disorders for INPP5D gene to outside databases

    Publications
    for INPP5D gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for INPP5D gene, integrated from 9 sources (see all 255):
    (articles sorted by number of sources associating them with INPP5D)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of human SHIP, the 145-kD inositol 5- phosphatase that associates with SHC after cytokine stimulation. (PubMed id 8874179)1, 2, 3, 9 Ware M.D.... Krystal G. (1996)
    2. The human SHIP gene is differentially expressed in cell lineages of the bone marrow and blood. (PubMed id 9058707)1, 2, 9 Geier S.J.... Rohrschneider L.R. (1997)
    3. The Src homology 2-containing inositol 5-phosphatase 1 (SHIP1) is involved in CD32a signaling in human neutrophils. (PubMed id 16682172)1, 2, 9 Vaillancourt M.... Naccache P.H. (2006)
    4. The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells. (PubMed id 10822173)1, 2, 9 Dunant N.M.... Resh M.D. (2000)
    5. CDw150 associates with src-homology 2-containing inositol phosphatase and modulates CD95-mediated apoptosis. (PubMed id 10229804)1, 2, 9 Mikhalap S.V....Sidorenko S.P. (1999)
    6. Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2. (PubMed id 8723348)1, 2, 9 Kavanaugh W.M....Williams L.T. (1996)
    7. Evidence that SHIP-1 contributes to phosphatidylinositol 3,4,5- trisphosphate metabolism in T lymphocytes and can regulate novel phosphoinositide 3-kinase effectors. (PubMed id 12421919)1, 2, 9 Freeburn R.W....Ward S.G. (2002)
    8. Purification and molecular cloning of SH2- and SH3-containing inositol polyphosphate-5-phosphatase, which is involved in the signaling pathway of granulocyte-macrophage colony-stimulating factor, erythropoietin, and Bcr-Abl. (PubMed id 9108392)1, 2 Odai H.... Hirai H. (1997)
    9. Cloning and expression of a human placenta inositol 1,3,4,5- tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate 5- phosphatase. (PubMed id 8769125)1, 2 Drayer A.L....Erneux C. (1996)
    10. The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase. (PubMed id 8643691)1, 3 Damen J.E....Krystal G. (1996)

    External Searches for INPP5D gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing INPP5D gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3635 HGNC: 6079 AceView: INPP5D Ensembl:ENSG00000168918 euGenes: HUgn3635
    ECgene: INPP5D Kegg: 3635 H-InvDB: INPP5D

    Other Databases showing INPP5D gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing INPP5D gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for INPP5D Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for INPP5D Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for INPP5D gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for INPP5D gene:
    Search GeneIP for patents involving INPP5D

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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