Aliases for INPP5D Gene
Aliases for INPP5D Gene
- Phosphatidylinositol 3,4,5-Trisphosphate 5-Phosphatase 1 3
- Signaling Inositol Polyphosphate 5 Phosphatase SIP-145 3
- Signaling Inositol Polyphosphate Phosphatase SHIP II 3
- Inositol Polyphosphate-5-Phosphatase Of 145 KDa 4
- SH2 Domain-Containing Inositol Phosphatase 1 4
- EC 3.1.3.n1 56
- EC 3.1.3.86 4
- EC 3.1.3 56
External Ids for INPP5D Gene
- HGNC: 6079
- Entrez Gene: 3635
- Ensembl: ENSG00000168918
- OMIM: 601582
- UniProtKB: Q92835
Previous GeneCards Identifiers for INPP5D Gene
- GC02P232000
- GC02P232751
- GC02P234086
- GC02P234127
- GC02P233851
- GC02P233633
- GC02P233924
- GC02P225771
Summaries for INPP5D Gene
-
This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]
GeneCards Summary for INPP5D Gene
INPP5D (Inositol Polyphosphate-5-Phosphatase D) is a Protein Coding gene. Diseases associated with INPP5D include Lymphoproliferative Syndrome. Among its related pathways are Cytokine Signaling in Immune system and Immune response IL-2 activation and signaling pathway. Gene Ontology (GO) annotations related to this gene include SH3 domain binding and PTB domain binding. An important paralog of this gene is INPPL1.
UniProtKB/Swiss-Prot for INPP5D Gene
-
Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6.
Additional gene information for INPP5D Gene
- Monarch Initiative
- Search for INPP5D at DataMed
- Search for INPP5D at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INPP5D Gene
Genomics for INPP5D Gene
GeneHancer (GH) Regulatory Elements for INPP5D Gene
Promoters and enhancers for INPP5D Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around INPP5D on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for INPP5D Gene
Genomic Locations for INPP5D Gene
- chr2:233,059,967-233,207,903
- (GRCh38/hg38)
- Size:
- 147,937 bases
- Orientation:
- Plus strand
- chr2:233,924,677-234,116,549
- (GRCh37/hg19)
Genomic View for INPP5D Gene
Genes around INPP5D on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q37.1 by Ensembl
- 2q37.1 by Entrez Gene
- 2q37.1 by HGNC
INPP5D Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for INPP5D Gene
Proteins for INPP5D Gene
-
Protein details for INPP5D Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q92835-SHIP1_HUMAN
- Recommended name:
- Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
- Protein Accession:
- Q92835
- O00145
- Q13544
- Q13545
- Q6P5A4
- Q92656
- Q9UE80
Protein attributes for INPP5D Gene
- Size:
- 1189 amino acids
- Molecular mass:
- 133292 Da
- Quaternary structure:
-
- Interacts with tyrosine phosphorylated form of SHC1 (PubMed:8874179). Interacts with tyrosine phosphorylated form of DOK1 (PubMed:10822173). Interacts with tyrosine phosphorylated form of DOK3 (By similarity). Interacts with tyrosine phosphorylated form of SLAMF1/CD150 (PubMed:10229804). Interacts with PTPN11 in response to IL-3 (By similarity). Interacts with receptor EPOR (By similarity). Interacts with receptors MS4A2/FCER1B and FCER1G (By similarity). Interacts with receptors FCGR2B and FCGR3 (By similarity). Interacts with receptor FCGR2A, leading to regulate gene expression during the phagocytic process (By similarity). Interacts with GRB2 (PubMed:8723348, PubMed:9108392). Interacts with PLCG1 (By similarity). Interacts with tyrosine kinases SRC and TEC (By similarity). Interacts with c-Met/MET (By similarity). Interacts with MILR1 (tyrosine-phosphorylated) (By similarity). Can weakly interact (via NPXY motif 2) with DAB2 (via PID domain); the interaction is impaired by tyrosine phosphorylation of the NPXY motif (By similarity). Interacts with FCRL3 and FCRL6 (tyrosine phosphorylated form) (PubMed:20933011, PubMed:19843936).
- SequenceCaution:
-
- Sequence=AAC50454.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for INPP5D Gene
Selected DME Specific Peptides for INPP5D Gene
- Q92835:
-
- KKILQLIKSQKF
- YTKQKATG
- TSDHSPVF
- DESYGEGCIALR
- IPHDIYV
- IIQKIKQQQ
- FIGTWNMG
- VESGKLI
- NSHLTSGSEKKLRRNQNY
- KYNLPSWCDR
- LGDKKLSPFN
- RFTHLFW
- KGQGKTRDD
- TLWNIRIVVLAKPEH
- GVTSQFVSK
Post-translational modifications for INPP5D Gene
- Tyrosine phosphorylated by the members of the SRC family after exposure to a diverse array of extracellular stimuli such as cytokines, growth factors, antibodies, chemokines, integrin ligands and hypertonic and oxidative stress. Phosphorylated upon IgG receptor FCGR2B-binding.
- Ubiquitination at posLast=365365
Other Protein References for INPP5D Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for INPP5D (SHIP)
- Cell Signaling Technology (CST) Antibodies for INPP5D (SHIP)
-
Custom Antibody ServicesOriGene Antibodies for INPP5D
- Novus Biologicals Antibodies for INPP5D
-
Abcam antibodies for INPP5D
- Invitrogen Antibodies for INPP5D
- antibodies-online: Search results for 147 available INPP5D Antibodies ranked by validation data
- Compare Top INPP5D Antibodies
-
Recommended
- 52 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 6 FACS Antibodies (anti-mouse)
- 4 IHC (p) Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 36 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 4 IHC (p) Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- 97 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 9 FACS Antibodies (anti-human)
- 7 IHC (p) Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- GeneTex INPP5D antibody for INPP5D
-
Santa Cruz Biotechnology (SCBT) Antibodies for INPP5D
Protein Products
-
OriGene Purified Proteins for INPP5D
- Search Origene for MassSpec and Protein Over-expression Lysates for INPP5D
- Origene Custom Protein Services for INPP5D
- Search GeneTex for Proteins for INPP5D
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for INPP5D (SHIP)
-
Cloud-Clone Corp. Assay Kits for INPP5D
Domains & Families for INPP5D Gene
Gene Families for INPP5D Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for INPP5D Gene
Suggested Antigen Peptide Sequences for INPP5D Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q92835UniProtKB/Swiss-Prot:
SHIP1_HUMAN :- The SH2 domain interacts with tyrosine phosphorylated forms of proteins such as SHC1 or PTPN11/SHP-2. It competes with that of GRB2 for binding to phosphorylated SHC1 to inhibit the Ras pathway. It is also required for tyrosine phosphorylation (By similarity).
- Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.
- Domain:
-
- The SH2 domain interacts with tyrosine phosphorylated forms of proteins such as SHC1 or PTPN11/SHP-2. It competes with that of GRB2 for binding to phosphorylated SHC1 to inhibit the Ras pathway. It is also required for tyrosine phosphorylation (By similarity).
- The NPXY sequence motif found in many tyrosine-phosphorylated proteins is required for the specific binding of the PID domain.
- Family:
-
- Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.
Function for INPP5D Gene
Molecular function for INPP5D Gene
- GENATLAS Biochemistry:
- inositol 1,4,5-triphosphate-5 phosphatase (145kDa),expressed in bone marrow in B and T cells and various tissues,interacting with phosphotyrosine inhibitory motif of Fcgamma RIIB (FCGR2B) for negative regulation of the immune receptor activation in both B and mast cells,down-regulating cytokine receptor signaling in myeloid cells,inhibiting ras signaling by competing with GRB2,signal terminating reaction in the inositol signaling pathway,negative regulator of lymphocyte activation
- UniProtKB/Swiss-Prot CatalyticActivity:
- 1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 3,4-diphosphate + phosphate.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated upon translocation to the sites of synthesis of PtdIns(3,4,5)P3 in the membrane.
- UniProtKB/Swiss-Prot Function:
- Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6.
Enzyme Numbers (IUBMB) for INPP5D Gene
Phenotypes From GWAS Catalog for INPP5D Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004445 | inositol-polyphosphate 5-phosphatase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 9148918 |
| GO:0016314 | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity | TAS | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
| GO:0017124 | SH3 domain binding | IEA | -- |
Phenotypes for INPP5D Gene
- MGI mutant phenotypes for INPP5D:
-
inferred from 10 alleles
- homeostasis/metabolism phenotype
- respiratory system phenotype
- muscle phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- integument phenotype
- hematopoietic system phenotype
- skeleton phenotype
- limbs/digits/tail phenotype
- GenomeRNAi human phenotypes for INPP5D:
Animal Models for INPP5D Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for INPP5D
-
-
ViGene Biosciences lentiviral particle packaged cDNA for INPP5D gene
-
ViGene Biosciences ready-to-package AAV shRNAs for INPP5D gene
- Search ViGene Biosciences for INPP5D
CRISPR Products
-
OriGene CRISPR knockouts for INPP5D
- genomics-online: gRNA clones - Search results for available INPP5D gene related products
- Applied Biological Materials CRISPR for INPP5D
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for INPP5D
- GenScript: Design CRISPR guide RNA sequences for INPP5D
miRNA for INPP5D Gene
- miRTarBase miRNAs that target INPP5D
miRNA Products
- Search ViGene Biosciences for INPP5D
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for INPP5D
- Browse OriGene Inhibitory RNA Products For INPP5D
- genomics-online: shRNA clones - Search results for available INPP5D gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for INPP5D gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for INPP5D
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for INPP5D
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available INPP5D gene related products
- orf clones - Search results for available INPP5D gene related products
- Applied Biological Materials Clones for INPP5D
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for INPP5D
-
ViGene Biosciences adenoviral particle packaged cDNA for INPP5D gene
-
ViGene Biosciences lentiviral particle packaged cDNA for INPP5D gene
-
ViGene Biosciences ready-to-package AAV shRNAs for INPP5D gene
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for INPP5D Gene
Localization for INPP5D Gene
Subcellular locations from UniProtKB/Swiss-Prot for INPP5D Gene
- Cytoplasm. Cell membrane; Peripheral membrane protein. Membrane raft. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Note=Translocates to the plasma membrane when activated, translocation is probably due to different mechanisms depending on the stimulus and cell type. Translocates from the cytoplasm to membrane ruffles in a FCGR3/CD16-dependent manner. Colocalizes with FC-gamma-RIIB receptor (FCGR2B) or FCGR3/CD16 at membrane ruffles. Tyrosine phosphorylation may also participate in membrane localization. {ECO:0000250 UniProtKB:Q9ES52}.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| plasma membrane | 4 |
| cytoskeleton | 4 |
| extracellular | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS,IDA | -- |
| GO:0005856 | cytoskeleton | IEA | -- |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for INPP5D Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Inositol phosphate metabolism (KEGG) | ||
| 2 | RET signaling | ||
| 3 | B cell receptor signaling pathway (KEGG) | ||
| 4 | Immune response Fc epsilon RI pathway | ||
| 5 | Cell surface interactions at the vascular wall | ||
Pathways by source for INPP5D Gene
1 Cell Signaling Technology pathway for INPP5D Gene
11 BioSystems pathways for INPP5D Gene
19 Reactome pathways for INPP5D Gene
5 KEGG pathways for INPP5D Gene
6 GeneGo (Thomson Reuters) pathways for INPP5D Gene
Interacting Proteins for INPP5D Gene
Selected Interacting proteins:
Q92835-SHIP1_HUMAN
ENSP00000352575
for INPP5D Gene via
MINT
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006661 | phosphatidylinositol biosynthetic process | TAS | -- |
| GO:0006796 | phosphate-containing compound metabolic process | TAS | 8769125 |
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0007165 | signal transduction | TAS | 8769125 |
| GO:0008285 | negative regulation of cell proliferation | IEA | -- |
Drugs & Compounds for INPP5D Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Phosphatidylinositol-3,4,5-trisphosphate |
|
|
||||
| Phosphate |
|
14265-44-2 |
|
|||
| PI(16:0/16:0) |
|
|
|
|||
| PI(16:0/16:1(9Z)) |
|
|
|
|||
| PI(16:0/16:2(9Z,12Z)) |
|
|
|
Transcripts for INPP5D Gene
mRNA/cDNA for INPP5D Gene
- (3) REFSEQ mRNAs :
- (14) Additional mRNA sequences :
- (349) Selected AceView cDNA sequences:
- (14) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for INPP5D Gene
CRISPR Products
-
OriGene CRISPR knockouts for INPP5D
- genomics-online: gRNA clones - Search results for available INPP5D gene related products
- Applied Biological Materials CRISPR for INPP5D
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for INPP5D
- GenScript: Design CRISPR guide RNA sequences for INPP5D
miRNA Products
- Search ViGene Biosciences for INPP5D
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for INPP5D
- Browse OriGene Inhibitory RNA Products For INPP5D
- genomics-online: shRNA clones - Search results for available INPP5D gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for INPP5D gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for INPP5D
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for INPP5D
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available INPP5D gene related products
- orf clones - Search results for available INPP5D gene related products
- Applied Biological Materials Clones for INPP5D
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||||||||||||
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| SP6: |
Expression for INPP5D Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Skeletal Muscle (Muscoskeletal System)
- Thyroid (Endocrine System)
- Bone (Muscoskeletal System)
- Blood (Hematopoietic System)
-
Spleen (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for INPP5D Gene
This gene is overexpressed in Whole Blood (x16.1) and Spleen (x5.6).
This gene is overexpressed in Lymph node (22.6), Peripheral blood mononuclear cells (11.0), and Tlymphocyte (7.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for INPP5D Gene
NURSA nuclear receptor signaling pathways regulating expression of INPP5D Gene:
INPP5DSOURCE GeneReport for Unigene cluster for INPP5D Gene:
Hs.262886mRNA Expression by UniProt/SwissProt for INPP5D Gene:
Q92835-SHIP1_HUMAN
Tissue specificity:
Specifically expressed in immune and hematopoietic cells. Expressed in bone marrow and blood cells. Levels vary considerably within this compartment. Present in at least 74% of immature CD34+ cells, whereas within the more mature population of CD33+ cells, it is present in only 10% of cells. Present in the majority of T-cells, while it is present in a minority of B-cells (at protein level).
Evidence on tissue expression from TISSUES for INPP5D Gene
- Lung(4.3)
- Liver(4.1)
- Blood(2.8)
- Bone marrow(2.6)
- Lymph node(2.2)
- Spleen(2.2)
- Nervous system(2.2)
- Intestine(2.1)
Primer Products
-
OriGene qPCR primer pairs for INPP5D
- genomics-online: primer clones - Search results for available INPP5D gene related products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for INPP5D Gene
Orthologs for INPP5D Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | INPP5D 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | INPP5D 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | INPP5D 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Inpp5d 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Inpp5d 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | INPP5D 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | INPP5D 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | INPP5D 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | INPP5D 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | inpp5d 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC68993 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | inpp5d 33 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Ocrl 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | ocrl-1 34 |
|
OneToMany |
- Species where no ortholog for INPP5D was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for INPP5D Gene
Paralogs for INPP5D Gene
(3) SIMAP similar genes for INPP5D Gene using alignment to 9 proteins:
Variants for INPP5D Gene
| SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000019992 | -- | 233,059,039(+) | C/T | upstream_transcript_variant | |
| rs1000047269 | -- | 233,083,412(+) | C/A | intron_variant | |
| rs1000049097 | -- | 233,191,018(+) | C/G | intron_variant | |
| rs1000066593 | -- | 233,131,753(+) | G/A | intron_variant | |
| rs1000073806 | -- | 233,096,062(+) | G/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1142800 | CNV | deletion | 17803354 |
| esv1209599 | CNV | deletion | 17803354 |
| esv2657351 | CNV | deletion | 23128226 |
| esv2721651 | CNV | deletion | 23290073 |
| esv3561165 | CNV | deletion | 23714750 |
| esv3561167 | CNV | deletion | 23714750 |
| esv3584374 | CNV | loss | 25503493 |
| nsv1138901 | CNV | deletion | 24896259 |
| nsv3213 | CNV | insertion | 18451855 |
| nsv473965 | CNV | novel sequence insertion | 20440878 |
| nsv474267 | CNV | novel sequence insertion | 20440878 |
| nsv479447 | CNV | novel sequence insertion | 20440878 |
| nsv479521 | CNV | novel sequence insertion | 20440878 |
| nsv479798 | CNV | novel sequence insertion | 20440878 |
| nsv480215 | CNV | novel sequence insertion | 20440878 |
| nsv480560 | CNV | novel sequence insertion | 20440878 |
| nsv480706 | CNV | novel sequence insertion | 20440878 |
| nsv480817 | CNV | novel sequence insertion | 20440878 |
| nsv520361 | CNV | loss | 19592680 |
| nsv527354 | CNV | gain | 19592680 |
| nsv584698 | CNV | loss | 21841781 |
| nsv953204 | CNV | duplication | 24416366 |
| nsv954251 | CNV | deletion | 24416366 |
Gene Damage Index Score:
8.17;
84.75% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for INPP5D Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INPP5D Gene
Disorders for INPP5D Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| lymphoproliferative syndrome |
|
Search INPP5D in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for INPP5D
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for INPP5D Gene
Publications for INPP5D Gene
- Cloning and characterization of human SHIP, the 145-kD inositol 5-phosphatase that associates with SHC after cytokine stimulation. (PMID: 8874179) Ware MD … Krystal G (Blood 1996) 2 3 4 22 58
- The Src homology 2-containing inositol 5-phosphatase 1 (SHIP1) is involved in CD32a signaling in human neutrophils. (PMID: 16682172) Vaillancourt M … Naccache PH (Cellular signalling 2006) 3 4 22 58
- Evidence that SHIP-1 contributes to phosphatidylinositol 3,4,5-trisphosphate metabolism in T lymphocytes and can regulate novel phosphoinositide 3-kinase effectors. (PMID: 12421919) Freeburn RW … Ward SG (Journal of immunology (Baltimore, Md. : 1950) 2002) 3 4 22 58
- The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells. (PMID: 10822173) Dunant NM … Resh MD (Cellular signalling 2000) 3 4 22 58
- CDw150 associates with src-homology 2-containing inositol phosphatase and modulates CD95-mediated apoptosis. (PMID: 10229804) Mikhalap SV … Sidorenko SP (Journal of immunology (Baltimore, Md. : 1950) 1999) 3 4 22 58
Products for INPP5D Gene
- R&D Systems Antibodies for INPP5D (SHIP)
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- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for INPP5D (SHIP)
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- Custom Antibody ServicesOriGene Antibodies for INPP5D
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- Cell Signaling Technology (CST) Antibodies for INPP5D (SHIP)
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- Novus Biologicals Antibodies for INPP5D
- Novus Biologicals lysates and proteins for INPP5D
- Novus Biologicals
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- Abcam antibodies for INPP5D
- Find your target
- Browse Primary Antibodies
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- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Cloud-Clone Corp. Assay Kits for INPP5D
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for INPP5D
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for INPP5D
- VectorBuilder custom plasmid, inducible vectors for INPP5D
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for INPP5D
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 147 available INPP5D Antibodies ranked by validation data
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- Recommended
- 52 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 6 FACS Antibodies (anti-mouse)
- 4 IHC (p) Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 36 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 4 IHC (p) Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- 97 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 9 FACS Antibodies (anti-human)
- 7 IHC (p) Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- antibodies-online: Search results for 16 available INPP5D Elisa Kits ranked by validation data
- Compare Top INPP5D Elisa Kits
- antibodies-online: Search results for 3 available INPP5D Proteins ranked by validation data
- Compare Top INPP5D Proteins
- GeneTex INPP5D antibody for INPP5D
- Search GeneTex for Proteins for INPP5D
- ViGene Biosciences adenoviral particle packaged cDNA for INPP5D gene
- ViGene Biosciences lentiviral particle packaged cDNA for INPP5D gene
- ViGene Biosciences ready-to-package AAV shRNAs for INPP5D gene
- Search ViGene Biosciences for INPP5D
- Santa Cruz Biotechnology (SCBT) Antibodies for INPP5D
- Search Santa Cruz Biotechnology (SCBT) for INPP5D siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for INPP5D
- Horizon Cell Lines for INPP5D
- genomics-online: cdna clones - Search results for available INPP5D gene related products
- orf clones - Search results for available INPP5D gene related products
- genomics-online: gRNA clones - Search results for available INPP5D gene related products
- genomics-online: primer clones - Search results for available INPP5D gene related products
- genomics-online: shRNA clones - Search results for available INPP5D gene related products
Sources for INPP5D Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
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- (119) Disease Ontology
- (120) Genetics Home Reference
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- (123) CDC
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- (125) NCBI Bookshelf
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- (133) ENCODE
- (134) ProSci
- (135) Horizon
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- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
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- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew