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INPP5D Gene(Protein Coding)

Inositol Polyphosphate-5-Phosphatase D

GCID:
GC02P233059
GIFtS:
62
Genes Participants
UDN Logo

Aliases for INPP5D Gene

Aliases for INPP5D Gene

  • Inositol Polyphosphate-5-Phosphatase D 2 3 5
  • SH2 Domain-Containing Inositol 5-Phosphatase 1 2 3 4
  • Inositol Polyphosphate-5-Phosphatase, 145kDa 2 3
  • Inositol Polyphosphate-5-Phosphatase, 145kD 2 3
  • P150Ship 3 4
  • SIP-145 3 4
  • SHIP-1 3 4
  • Hp51CN 3 4
  • SHIP1 3 4
  • SHIP 3 4
  • Phosphatidylinositol 3,4,5-Trisphosphate 5-Phosphatase 1 3
  • Signaling Inositol Polyphosphate 5 Phosphatase SIP-145 3
  • Signaling Inositol Polyphosphate Phosphatase SHIP II 3
  • Inositol Polyphosphate-5-Phosphatase Of 145 KDa 4
  • SH2 Domain-Containing Inositol Phosphatase 1 4
  • EC 3.1.3.n1 61
  • EC 3.1.3.86 4
  • EC 3.1.3 61

External Ids for INPP5D Gene

Previous GeneCards Identifiers for INPP5D Gene

  • GC02P232000
  • GC02P232751
  • GC02P234086
  • GC02P234127
  • GC02P233851
  • GC02P233633
  • GC02P233924
  • GC02P225771

Summaries for INPP5D Gene

Entrez Gene Summary for INPP5D Gene

  • This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]

GeneCards Summary for INPP5D Gene

INPP5D (Inositol Polyphosphate-5-Phosphatase D) is a Protein Coding gene. Among its related pathways are Inositol phosphate metabolism (KEGG) and Kit receptor signaling pathway. GO annotations related to this gene include SH3 domain binding and PTB domain binding. An important paralog of this gene is INPPL1.

UniProtKB/Swiss-Prot for INPP5D Gene

  • Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6.

Gene Wiki entry for INPP5D Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INPP5D Gene

Genomics for INPP5D Gene

Products:

  1. Regulatory Element

Regulatory Elements for INPP5D Gene

Enhancers for INPP5D Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G233072 1.9 FANTOM5 Ensembl ENCODE dbSUPER 30.1 +21.2 21174 16.9 HDGF PKNOX1 FOXA2 WRNIP1 ARID4B DMAP1 ZNF48 GATA2 ZNF143 ZNF207 INPP5D ATG16L1 NGEF SCARNA6 GIGYF2 DGKD GC02P233069 RN7SL32P
GH02G232900 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.9 -158.2 -158170 1.8 TAF1 JUN MAX SIN3A RAD21 ZIC2 FOSL1 POLR2A SMC3 FOSL2 NGEF C2orf82 LOC101928881 INPP5D PIR45244
GH02G233090 1.5 Ensembl ENCODE dbSUPER 11.6 +32.5 32488 3.5 HDGF PKNOX1 ATF1 ARNT TCF12 ZNF766 ELK1 GATA2 JUNB NCOA1 INPP5D LOC105373929 TIGD1 GC02P233069 RN7SL32P
GH02G233163 1.1 Ensembl ENCODE 15.8 +105.5 105456 3.3 HDGF EGR1 ZSCAN5C CREM EGR2 SMARCA5 CEBPB SP1 MBD2 MYNN INPP5D RN7SL32P GC02P233069
GH02G233099 1.4 Ensembl ENCODE dbSUPER 11.9 +40.4 40362 2.4 HDGF PKNOX1 FOXA2 TBL1XR1 BMI1 YBX1 RFX5 CHAMP1 RELB ETV6 INPP5D C2orf82 GC02P233069 RN7SL32P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around INPP5D on UCSC Golden Path with GeneCards custom track

Promoters for INPP5D Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000132008 1033 1601 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF48 YY1 ZNF143 SP5

Transcription factor binding sites by QIAGEN in the INPP5D gene promoter:

Genomic Location for INPP5D Gene

Chromosome:
2
Start:
233,059,967 bp from pter
End:
233,207,903 bp from pter
Size:
147,937 bases
Orientation:
Plus strand

Genomic View for INPP5D Gene

Genes around INPP5D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INPP5D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INPP5D Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for INPP5D Gene

Proteins for INPP5D Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for INPP5D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92835-SHIP1_HUMAN
    Recommended name:
    Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
    Protein Accession:
    Q92835
    Secondary Accessions:
    • O00145
    • Q13544
    • Q13545
    • Q6P5A4
    • Q92656
    • Q9UE80

    Protein attributes for INPP5D Gene

    Size:
    1189 amino acids
    Molecular mass:
    133292 Da
    Quaternary structure:
    • Interacts with tyrosine phosphorylated forms of SHC1, DOK1, DOK3, PTPN11/SHP-2, SLAMF1/CD150. Interacts with PTPN11 in response to IL-3. Interacts with receptors EPOR, MS4A2/FCER1B and FCER1G, FCGR2A, FCGR2B and FCGR3. Interacts with GRB2 and PLCG1. Interacts with tyrosine kinases SRC and TEC. Interacts with FCGR2A, leading to regulate gene expression during the phagocytic process. Interacts with c-Met/MET (By similarity). Interacts with MILR1 (tyrosine-phosphorylated). Can weakly interact (via NPXY motif 2) with DAB2 (via PID domain); the interaction is impaired by tyrosine phosphorylation of the NPXY motif (By similarity).
    SequenceCaution:
    • Sequence=AAC50454.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for INPP5D Gene

    Alternative splice isoforms for INPP5D Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for INPP5D Gene

Protein Expression for INPP5D Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for INPP5D Gene

Q92835:
  • KKILQLIKSQKF
  • YTKQKATG
  • TSDHSPVF
  • DESYGEGCIALR
  • IPHDIYV
  • IIQKIKQQQ
  • FIGTWNMG
  • VESGKLI
  • NSHLTSGSEKKLRRNQNY
  • KYNLPSWCDR
  • LGDKKLSPFN
  • RFTHLFW
  • KGQGKTRDD
  • TLWNIRIVVLAKPEH
  • GVTSQFVSK

Post-translational modifications for INPP5D Gene

  • Tyrosine phosphorylated by the members of the SRC family after exposure to a diverse array of extracellular stimuli such as cytokines, growth factors, antibodies, chemokines, integrin ligands and hypertonic and oxidative stress. Phosphorylated upon IgG receptor FCGR2B-binding.
  • Ubiquitination at posLast=365365
  • Modification sites at PhosphoSitePlus

Other Protein References for INPP5D Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for INPP5D (SHIP)

Assay Products

  • Cloud-Clone Corp. Assay Kits for INPP5D

Domains & Families for INPP5D Gene

Gene Families for INPP5D Gene

HGNC:
IUPHAR :

Protein Domains for INPP5D Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for INPP5D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92835

UniProtKB/Swiss-Prot:

SHIP1_HUMAN :
  • The SH2 domain interacts with tyrosine phosphorylated forms of proteins such as SHC1 or PTPN11/SHP-2. It competes with that of GRB2 for binding to phosphorylated SHC1 to inhibit the Ras pathway. It is also required for tyrosine phosphorylation (By similarity).
  • Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.
Domain:
  • The SH2 domain interacts with tyrosine phosphorylated forms of proteins such as SHC1 or PTPN11/SHP-2. It competes with that of GRB2 for binding to phosphorylated SHC1 to inhibit the Ras pathway. It is also required for tyrosine phosphorylation (By similarity).
  • The NPXY sequence motif found in many tyrosine-phosphorylated proteins is required for the specific binding of the PID domain.
Family:
  • Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.
genes like me logo Genes that share domains with INPP5D: view

Function for INPP5D Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for INPP5D Gene

GENATLAS Biochemistry:
inositol 1,4,5-triphosphate-5 phosphatase (145kDa),expressed in bone marrow in B and T cells and various tissues,interacting with phosphotyrosine inhibitory motif of Fcgamma RIIB (FCGR2B) for negative regulation of the immune receptor activation in both B and mast cells,down-regulating cytokine receptor signaling in myeloid cells,inhibiting ras signaling by competing with GRB2,signal terminating reaction in the inositol signaling pathway,negative regulator of lymphocyte activation
UniProtKB/Swiss-Prot CatalyticActivity:
1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 3,4-diphosphate + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated upon translocation to the sites of synthesis of PtdIns(3,4,5)P3 in the membrane.
UniProtKB/Swiss-Prot Function:
Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6.

Enzyme Numbers (IUBMB) for INPP5D Gene

Gene Ontology (GO) - Molecular Function for INPP5D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004445 inositol-polyphosphate 5-phosphatase activity TAS,IEA --
GO:0005515 protein binding IPI 9148918
GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity TAS --
GO:0016787 hydrolase activity IEA --
GO:0017124 SH3 domain binding IEA --
genes like me logo Genes that share ontologies with INPP5D: view
genes like me logo Genes that share phenotypes with INPP5D: view

Animal Models for INPP5D Gene

MGI Knock Outs for INPP5D:

Animal Model Products

CRISPR Products

miRNA for INPP5D Gene

miRTarBase miRNAs that target INPP5D

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for INPP5D Gene

Localization for INPP5D Gene

Subcellular locations from UniProtKB/Swiss-Prot for INPP5D Gene

Cytoplasm. Cell membrane; Peripheral membrane protein. Membrane raft. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Note=Translocates to the plasma membrane when activated, translocation is probably due to different mechanisms depending on the stimulus and cell type. Translocates from the cytoplasm to membrane ruffles in a FCGR3/CD16-dependent manner. Colocalizes with FC-gamma-RIIB receptor (FCGR2B) or FCGR3/CD16 at membrane ruffles. Tyrosine phosphorylation may also participate in membrane localization. {ECO:0000250 UniProtKB:Q9ES52}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for INPP5D gene
Compartment Confidence
cytosol 5
plasma membrane 4
cytoskeleton 4
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for INPP5D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA,TAS --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with INPP5D: view

Pathways & Interactions for INPP5D Gene

genes like me logo Genes that share pathways with INPP5D: view

SIGNOR curated interactions for INPP5D Gene

Is activated by:

Gene Ontology (GO) - Biological Process for INPP5D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006661 phosphatidylinositol biosynthetic process TAS --
GO:0006796 phosphate-containing compound metabolic process TAS 8769125
GO:0006915 apoptotic process IEA --
GO:0007165 signal transduction TAS 8769125
GO:0008285 negative regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with INPP5D: view

Drugs & Compounds for INPP5D Gene

Products:

  1. Drug

(12) Drugs for INPP5D Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(386) Additional Compounds for INPP5D Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphatidylinositol-3,4,5-trisphosphate
  • 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate)
  • 1-Phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
  • Phosphatidylinositol-3,4,5-trisphosphate
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
 14265-44-2
PI(16:0/16:0)
  • 1,2-Dihexadecanoyl-rac-glycero-3-phospho-(1'-myo-inositol)
  • 1,2-Dipalmitoyl-rac-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:0)
  • Phosphatidylinositol(32:0)
  • PI(16:0/16:0)
PI(16:0/16:1(9Z))
  • 1-Hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Palmitoyl-2-palmitoleoyl-sn-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:1)
  • Phosphatidylinositol(16:0/16:1n7)
  • Phosphatidylinositol(16:0/16:1w7)
PI(16:0/16:2(9Z,12Z))
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoate
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoate)-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoic acid
  • 1-Palmitoyl-2-(9Z,12Z-hexadecadienoate
  • 1-Palmitoyl-2-(9Z,12Z-hexadecadienoate)-sn-glycero-3-phosphoinositol
genes like me logo Genes that share compounds with INPP5D: view

Transcripts for INPP5D Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for INPP5D Gene

(3) REFSEQ mRNAs :
(14) Additional mRNA sequences :
(349) Selected AceView cDNA sequences:
(14) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for INPP5D Gene

Inositol polyphosphate-5-phosphatase, 145kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for INPP5D Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1: - - - - -
SP2:
SP3: - - -
SP4: -
SP5:
SP6:

Relevant External Links for INPP5D Gene

GeneLoc Exon Structure for
INPP5D
ECgene alternative splicing isoforms for
INPP5D

Expression for INPP5D Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for INPP5D Gene

mRNA expression in normal human tissues for INPP5D Gene
mRNA expression by BioGPS for INPP5D GenemRNA expression by GTEx for INPP5D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for INPP5D Gene

This gene is overexpressed in Whole Blood (x16.1) and Spleen (x5.6).

Protein differential expression in normal tissues from HIPED for INPP5D Gene

This gene is overexpressed in Lymph node (22.6), Peripheral blood mononuclear cells (11.0), and Tlymphocyte (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for INPP5D Gene



NURSA nuclear receptor signaling pathways regulating expression of INPP5D Gene:

INPP5D

SOURCE GeneReport for Unigene cluster for INPP5D Gene:

Hs.262886

mRNA Expression by UniProt/SwissProt for INPP5D Gene:

Q92835-SHIP1_HUMAN
Tissue specificity: Specifically expressed in immune and hematopoietic cells. Expressed in bone marrow and blood cells. Levels vary considerably within this compartment. Present in at least 74% of immature CD34+ cells, whereas within the more mature population of CD33+ cells, it is present in only 10% of cells. Present in the majority of T-cells, while it is present in a minority of B-cells (at protein level).

Evidence on tissue expression from TISSUES for INPP5D Gene

  • Lung(4.3)
  • Liver(4.1)
  • Blood(2.8)
  • Bone marrow(2.5)
  • Lymph node(2.3)
  • Spleen(2.2)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with INPP5D: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for INPP5D Gene

Orthologs for INPP5D Gene

This gene was present in the common ancestor of animals.

Orthologs for INPP5D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia INPP5D 34 35
  • 99.46 (n)
cow
(Bos Taurus)
 Mammalia INPP5D 34 35
  • 88.63 (n)
dog
(Canis familiaris)
 Mammalia INPP5D 34 35
  • 87.88 (n)
rat
(Rattus norvegicus)
 Mammalia Inpp5d 34
  • 85.38 (n)
mouse
(Mus musculus)
 Mammalia Inpp5d 34 16 35
  • 85.25 (n)
oppossum
(Monodelphis domestica)
 Mammalia INPP5D 35
  • 80 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia INPP5D 35
  • 63 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves INPP5D 34 35
  • 70.76 (n)
lizard
(Anolis carolinensis)
 Reptilia INPP5D 35
  • 64 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia inpp5d 34
  • 60.84 (n)
African clawed frog
(Xenopus laevis)
 Amphibia MGC68993 34
zebrafish
(Danio rerio)
 Actinopterygii inpp5d 34 35
  • 61.59 (n)
fruit fly
(Drosophila melanogaster)
 Insecta Ocrl 35
  • 17 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea ocrl-1 35
  • 20 (a)
 OneToMany
Species where no ortholog for INPP5D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for INPP5D Gene

ENSEMBL:
Gene Tree for INPP5D (if available)
TreeFam:
Gene Tree for INPP5D (if available)

Paralogs for INPP5D Gene

Paralogs for INPP5D Gene

(3) SIMAP similar genes for INPP5D Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with INPP5D: view

Variants for INPP5D Gene

Sequence variations from dbSNP and Humsavar for INPP5D Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000019992 -- 233,059,039(+) TGAGC(C/T)CCTGG upstream-variant-2KB
rs1000047269 -- 233,083,412(+) CTGTG(A/C)CACTC intron-variant
rs1000049097 -- 233,191,018(+) GAAAA(C/G)TGTCT intron-variant
rs1000066593 -- 233,131,753(+) AAATG(A/G)GATTT intron-variant
rs1000073806 -- 233,096,062(+) TTTTT(A/G)TTGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for INPP5D Gene

Variant ID Type Subtype PubMed ID
esv1142800 CNV deletion 17803354
esv1209599 CNV deletion 17803354
esv2657351 CNV deletion 23128226
esv2721651 CNV deletion 23290073
esv3561165 CNV deletion 23714750
esv3561167 CNV deletion 23714750
esv3584374 CNV loss 25503493
nsv1138901 CNV deletion 24896259
nsv3213 CNV insertion 18451855
nsv473965 CNV novel sequence insertion 20440878
nsv474267 CNV novel sequence insertion 20440878
nsv479447 CNV novel sequence insertion 20440878
nsv479521 CNV novel sequence insertion 20440878
nsv479798 CNV novel sequence insertion 20440878
nsv480215 CNV novel sequence insertion 20440878
nsv480560 CNV novel sequence insertion 20440878
nsv480706 CNV novel sequence insertion 20440878
nsv480817 CNV novel sequence insertion 20440878
nsv520361 CNV loss 19592680
nsv527354 CNV gain 19592680
nsv584698 CNV loss 21841781
nsv953204 CNV duplication 24416366
nsv954251 CNV deletion 24416366

Variation tolerance for INPP5D Gene

Gene Damage Index Score: 8.17; 84.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for INPP5D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
INPP5D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INPP5D Gene

Disorders for INPP5D Gene

Relevant External Links for INPP5D

Genetic Association Database (GAD)
INPP5D
Human Genome Epidemiology (HuGE) Navigator
INPP5D
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
INPP5D

No disorders were found for INPP5D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for INPP5D Gene

Publications for INPP5D Gene

  1. Cloning and characterization of human SHIP, the 145-kD inositol 5- phosphatase that associates with SHC after cytokine stimulation. (PMID: 8874179) Ware M.D. … Krystal G. (Blood 1996) 2 3 4 22 64
  2. The Src homology 2-containing inositol 5-phosphatase 1 (SHIP1) is involved in CD32a signaling in human neutrophils. (PMID: 16682172) Vaillancourt M. … Naccache P.H. (Cell. Signal. 2006) 3 4 22 64
  3. Evidence that SHIP-1 contributes to phosphatidylinositol 3,4,5- trisphosphate metabolism in T lymphocytes and can regulate novel phosphoinositide 3-kinase effectors. (PMID: 12421919) Freeburn R.W. … Ward S.G. (J. Immunol. 2002) 3 4 22 64
  4. The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells. (PMID: 10822173) Dunant N.M. … Resh M.D. (Cell. Signal. 2000) 3 4 22 64
  5. CDw150 associates with src-homology 2-containing inositol phosphatase and modulates CD95-mediated apoptosis. (PMID: 10229804) Mikhalap S.V. … Sidorenko S.P. (J. Immunol. 1999) 3 4 22 64

Products for INPP5D Gene

Sources for INPP5D Gene

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