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Aliases for INPP5B Gene

Aliases for INPP5B Gene

  • Inositol Polyphosphate-5-Phosphatase, 75kDa 2 3
  • Phosphoinositide 5-Phosphatase 3 4
  • EC 4 63
  • 5PTASE 3 4
  • Type II Inositol 1,4,5-Trisphosphate 5-Phosphatase 3
  • 75 KDa Inositol Polyphosphate-5-Phosphatase 4
  • Inositol Polyphosphate-5-Phosphatase, 75kD 2
  • EC 3.1.3 63
  • OCRL2 4

External Ids for INPP5B Gene

Previous GeneCards Identifiers for INPP5B Gene

  • GC01M038162
  • GC01M037382
  • GC01M037754
  • GC01M037809
  • GC01M037807
  • GC01M037996
  • GC01M038326
  • GC01M036444

Summaries for INPP5B Gene

Entrez Gene Summary for INPP5B Gene

  • This gene encodes a member of a family of inositol polyphosphate-5-phosphatases. These enzymes function in the regulation of calcium signaling by inactivating inositol phosphates. The encoded protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jul 2014]

GeneCards Summary for INPP5B Gene

INPP5B (Inositol Polyphosphate-5-Phosphatase, 75kDa) is a Protein Coding gene. Diseases associated with INPP5B include oculocerebrorenal syndrome. Among its related pathways are Signaling by GPCR and Rho GTPase cycle. GO annotations related to this gene include phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity and inositol-1,4,5-trisphosphate 5-phosphatase activity. An important paralog of this gene is SYNJ2.

UniProtKB/Swiss-Prot for INPP5B Gene

  • Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events.

Gene Wiki entry for INPP5B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INPP5B Gene

Genomics for INPP5B Gene

Regulatory Elements for INPP5B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for INPP5B Gene

37,860,697 bp from pter
37,947,057 bp from pter
86,361 bases
Minus strand

Genomic View for INPP5B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for INPP5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INPP5B Gene

Proteins for INPP5B Gene

  • Protein details for INPP5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Type II inositol 1,4,5-trisphosphate 5-phosphatase
    Protein Accession:
    Secondary Accessions:
    • C9J6U5
    • Q5VSG9
    • Q5VSH0
    • Q5VSH1
    • Q658Q5
    • Q6P6D4
    • Q6PD53
    • Q86YE1

    Protein attributes for INPP5B Gene

    993 amino acids
    Molecular mass:
    112852 Da
    Quaternary structure:
    • Interacts with APPL1, FAM109A and FAM109B. Interacts with several Rab GTPases, at least RAB1A, RAB2A, RAB5A, RAB6A, RAB8A, RAB9A and RAB33B; these interactions may play a dual role in targeting INPP5B to the specific membranes and stimulating the phosphatase activity.
    • Sequence=AAA79207.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for INPP5B Gene

    Alternative splice isoforms for INPP5B Gene


neXtProt entry for INPP5B Gene

Proteomics data for INPP5B Gene at MOPED

Selected DME Specific Peptides for INPP5B Gene

Post-translational modifications for INPP5B Gene

  • Isoprenylation at Cys-990 may be required for localization at the membrane.
  • May be proteolytically cleaved after Lys-320 as inferred from N-terminal protein sequence of the 75 kda form.
  • Ubiquitination at Lys312 and Lys404
  • Modification sites at PhosphoSitePlus

Other Protein References for INPP5B Gene

Antibody Products

Domains for INPP5B Gene

Gene Families for INPP5B Gene

Suggested Antigen Peptide Sequences for INPP5B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P32019
  • The ASH (ASPM-SPD2-Hydin) and RhoGAP (Rho GTPase activating) domains form a single folding module. The ASH domain has an immunoglobulin-like fold, the Rho-GAP domain lacks the catalytic arginine and is catalytically inactive. The ASH-RhoGAP module regulates the majority of the protein-protein interactions currently described. The ASH domain mediates association with membrane-targeting Rab GTPases. The Rho-GAP domain interacts with the endocytic adapter APPL1, which is then displaced by FAM109A and FAM109B as endosomes mature, all three interactions relie on F&H motifs, an approximately 12-13 amino-acid sequence centered around Phe and His residues essential for binding (By similarity).
  • Contains 1 PH domain.
  • Contains 1 Rho-GAP domain.
  • Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.
genes like me logo Genes that share domains with INPP5B: view

Function for INPP5B Gene

Molecular function for INPP5B Gene

GENATLAS Biochemistry:
inositol 1,4,5-triphosphate 5-phosphatase (75kDa),expressed in megakaryocytes,placenta,signal terminating reaction in the inositol signaling pathway
UniProtKB/Swiss-Prot CatalyticActivity:
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.
UniProtKB/Swiss-Prot Function:
Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events.

Enzyme Numbers (IUBMB) for INPP5B Gene

Gene Ontology (GO) - Molecular Function for INPP5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IDA 7721860
GO:0005515 protein binding IPI 21233288
GO:0046872 metal ion binding IEA --
GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity IDA 7721860
genes like me logo Genes that share ontologies with INPP5B: view
genes like me logo Genes that share phenotypes with INPP5B: view

Animal Models for INPP5B Gene

MGI Knock Outs for INPP5B:

Animal Model Products

miRNA for INPP5B Gene

miRTarBase miRNAs that target INPP5B

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for INPP5B

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for INPP5B Gene

Localization for INPP5B Gene

Subcellular locations from UniProtKB/Swiss-Prot for INPP5B Gene

Cytoplasm, cytosol. Endoplasmic reticulum-Golgi intermediate compartment. Early endosome membrane. Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, phagosome membrane. Golgi apparatus.

Subcellular locations from

Jensen Localization Image for INPP5B Gene COMPARTMENTS Subcellular localization image for INPP5B gene
Compartment Confidence
cytosol 5
endosome 5
golgi apparatus 5
cytoskeleton 4
plasma membrane 4
nucleus 2
extracellular 1
vacuole 1

Gene Ontology (GO) - Cellular Components for INPP5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm IDA --
GO:0005768 endosome --
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA --
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with INPP5B: view

Pathways for INPP5B Gene

genes like me logo Genes that share pathways with INPP5B: view

Interacting Proteins for INPP5B Gene

Gene Ontology (GO) - Biological Process for INPP5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0007283 spermatogenesis IEA --
GO:0030317 sperm motility IEA --
genes like me logo Genes that share ontologies with INPP5B: view

Compounds for INPP5B Gene

(4) HMDB Compounds for INPP5B Gene

Compound Synonyms Cas Number PubMed IDs
  • 1-Phosphatidyl-1D-myo-inositol
Not Available
  • Ca
  • NFB Orthophosphate
  • Dihydrogen oxide

(1) Drugbank Compounds for INPP5B Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
47055-78-7 target
genes like me logo Genes that share compounds with INPP5B: view

Transcripts for INPP5B Gene

Unigene Clusters for INPP5B Gene

Inositol polyphosphate-5-phosphatase, 75kDa:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for INPP5B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for INPP5B Gene

No ASD Table

Relevant External Links for INPP5B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for INPP5B Gene

mRNA expression in normal human tissues for INPP5B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for INPP5B Gene

This gene is overexpressed in Lymph node (28.9) and Peripheral blood mononuclear cells (25.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for INPP5B Gene

SOURCE GeneReport for Unigene cluster for INPP5B Gene Hs.449942

mRNA Expression by UniProt/SwissProt for INPP5B Gene

Tissue specificity: Platelets
genes like me logo Genes that share expressions with INPP5B: view

Expression partners for INPP5B Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for INPP5B Gene

Orthologs for INPP5B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for INPP5B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia INPP5B 35
  • 87.72 (n)
  • 88.71 (a)
  • 80 (a)
(Canis familiaris)
Mammalia INPP5B 35
  • 89.52 (n)
  • 90.59 (a)
  • 85 (a)
(Mus musculus)
Mammalia Inpp5b 35
  • 82.2 (n)
  • 82.04 (a)
Inpp5b 16
Inpp5b 36
  • 79 (a)
(Pan troglodytes)
Mammalia INPP5B 35
  • 98.42 (n)
  • 97.63 (a)
  • 91 (a)
(Rattus norvegicus)
Mammalia Inpp5b 35
  • 85.8 (n)
  • 87.08 (a)
(Monodelphis domestica)
Mammalia INPP5B 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia INPP5B 36
  • 64 (a)
(Gallus gallus)
Aves INPP5B 35
  • 73.48 (n)
  • 75.51 (a)
  • 65 (a)
(Anolis carolinensis)
Reptilia INPP5B 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497120 35
  • 68.05 (n)
  • 66.44 (a)
(Danio rerio)
Actinopterygii LOC563543 35
  • 62.25 (n)
  • 61.46 (a)
inpp5b 36
  • 60 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ocrl 36
  • 32 (a)
(Caenorhabditis elegans)
Secernentea ocrl-1 35
  • 43.64 (n)
  • 33.88 (a)
ocrl-1 36
  • 29 (a)
(Oryza sativa)
Liliopsida Os08g0425500 35
  • 49.83 (n)
  • 39.59 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
-- 36
  • 41 (a)
Species with no ortholog for INPP5B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for INPP5B Gene

Gene Tree for INPP5B (if available)
Gene Tree for INPP5B (if available)

Paralogs for INPP5B Gene

Paralogs for INPP5B Gene

Selected SIMAP similar genes for INPP5B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with INPP5B: view

Variants for INPP5B Gene

Sequence variations from dbSNP and Humsavar for INPP5B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs980 -- 37,862,320(-) ACCCA(A/C/T)TCTGA missense, reference
rs3843 -- 37,862,310(-) AGCCT(A/C)TCTCT utr-variant-3-prime
rs871524 -- 37,945,773(+) CCGCC(A/G)TGCTC reference, synonymous-codon
rs899745 -- 37,889,070(-) GCACT(A/G)TGTTG intron-variant
rs1471522 -- 37,925,398(+) AGAGC(A/G)TAATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for INPP5B Gene

Variant ID Type Subtype PubMed ID
nsv870730 CNV Gain 21882294
nsv510 CNV Insertion 18451855
esv1640356 CNV Deletion 17803354
esv2747275 CNV Deletion 23290073

Relevant External Links for INPP5B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INPP5B Gene

Disorders for INPP5B Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for INPP5B Gene in MalaCards »

(1) Diseases for INPP5B Gene including...

(1) University of Copenhagen DISEASES for INPP5B Gene

Relevant External Links for INPP5B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with INPP5B: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for INPP5B Gene

Publications for INPP5B Gene

  1. Cloning and expression of human 75-kDa inositol polyphosphate-5- phosphatase. (PMID: 1718960) Ross T.S. … Majerus P.W. (J. Biol. Chem. 1991) 2 3 4
  2. Localization of the 75-kDa inositol polyphosphate-5-phosphatase (INPP5B) to human chromosome band 1p34. (PMID: 8125013) JAonne P.A. … Nussbaum R.L. (Cytogenet. Cell Genet. 1994) 3 23
  3. Mapping of the 75-kDa inositol polyphosphate-5-phosphatase (Inpp5b) to distal mouse chromosome 4 and its exclusion as a candidate gene for dysgenetic lens. (PMID: 8530037) JAonne P.A. … Nussbaum R.L. (Genomics 1995) 3 23
  4. Properties of type II inositol polyphosphate 5-phosphatase. (PMID: 7721860) Jefferson A.B. … Majerus P.W. (J. Biol. Chem. 1995) 3 4
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for INPP5B Gene

Sources for INPP5B Gene

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