Aliases for INPP5B Gene
External Ids for INPP5B Gene
Previous GeneCards Identifiers for INPP5B Gene
This gene encodes a member of a family of inositol polyphosphate-5-phosphatases. These enzymes function in the regulation of calcium signaling by inactivating inositol phosphates. The encoded protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jul 2014]
GeneCards Summary for INPP5B Gene
INPP5B (Inositol Polyphosphate-5-Phosphatase B) is a Protein Coding gene. Among its related pathways are Metabolism and Inositol phosphate metabolism (REACTOME). GO annotations related to this gene include phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity and inositol-1,4,5-trisphosphate 5-phosphatase activity. An important paralog of this gene is OCRL.
UniProtKB/Swiss-Prot for INPP5B Gene
Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events.