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Aliases for INPP5A Gene

Aliases for INPP5A Gene

  • Inositol Polyphosphate-5-Phosphatase A 2 3 5
  • Type I Inositol-1,4,5-Trisphosphate 5-Phosphatase 2 3
  • Inositol Polyphosphate-5-Phosphatase, 40kDa 2 3
  • 43 KDa Inositol Polyphosphate 5-Phophatase 2 3
  • Inositol Polyphosphate-5-Phosphatase, 40kD 2 3
  • CTCL Tumor Antigen HD-CL-02 2 3
  • InsP3 5-Phosphatase 2 3
  • 5PTASE 3 4
  • Type I Inositol-1,4,5-Trisphosphate 5-Phophatase 3
  • Inositol Trisphosphate-5-Phosphatase, 40kD 3
  • Inositol Polyphosphate 5-Phophatase 2
  • EC 4
  • 40kDa 2

External Ids for INPP5A Gene

Previous GeneCards Identifiers for INPP5A Gene

  • GC10P133261
  • GC10P133484
  • GC10P134228
  • GC10P133786
  • GC10P133785
  • GC10P134201
  • GC10P134351
  • GC10P127903

Summaries for INPP5A Gene

Entrez Gene Summary for INPP5A Gene

  • The protein encoded by this gene is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. [provided by RefSeq, Jul 2008]

GeneCards Summary for INPP5A Gene

INPP5A (Inositol Polyphosphate-5-Phosphatase A) is a Protein Coding gene. Diseases associated with INPP5A include X-Linked Disease and Joubert Syndrome 1. Among its related pathways are Inositol phosphate metabolism (REACTOME) and Metabolism. GO annotations related to this gene include inositol-polyphosphate 5-phosphatase activity and inositol-1,4,5-trisphosphate 5-phosphatase activity.

UniProtKB/Swiss-Prot for INPP5A Gene

  • Major isoenzyme hydrolyzing the calcium-mobilizing second messenger Ins(1,4,5)P3, this is a signal-terminating reaction.

Gene Wiki entry for INPP5A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INPP5A Gene

Genomics for INPP5A Gene

Regulatory Elements for INPP5A Gene

Enhancers for INPP5A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around INPP5A on UCSC Golden Path with GeneCards custom track

Promoters for INPP5A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around INPP5A on UCSC Golden Path with GeneCards custom track

Genomic Location for INPP5A Gene

132,537,784 bp from pter
132,783,480 bp from pter
245,697 bases
Plus strand

Genomic View for INPP5A Gene

Genes around INPP5A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INPP5A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INPP5A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INPP5A Gene

Proteins for INPP5A Gene

  • Protein details for INPP5A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Type I inositol 1,4,5-trisphosphate 5-phosphatase
    Protein Accession:
    Secondary Accessions:
    • D3DXI3
    • Q14640
    • Q5JSF1

    Protein attributes for INPP5A Gene

    412 amino acids
    Molecular mass:
    47820 Da
    Quaternary structure:
    No Data Available

neXtProt entry for INPP5A Gene

Proteomics data for INPP5A Gene at MOPED

Post-translational modifications for INPP5A Gene

  • Ubiquitination at Lys 73, Lys 265, Lys 284, Lys 307, and Lys 358
  • Modification sites at PhosphoSitePlus

Other Protein References for INPP5A Gene

No data available for DME Specific Peptides for INPP5A Gene

Domains & Families for INPP5A Gene

Gene Families for INPP5A Gene

Protein Domains for INPP5A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type I family.
  • Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type I family.
genes like me logo Genes that share domains with INPP5A: view

Function for INPP5A Gene

Molecular function for INPP5A Gene

GENATLAS Biochemistry:
inositol 1,4,5-triphosphate 5-phosphatase (43kDa) membrane-associated,predominantly expressed in heart,brain,skeletal,muscle,signal terminating reaction in the inositol signaling pathway
UniProtKB/Swiss-Prot CatalyticActivity:
D-myo-inositol 1,4,5-trisphosphate + H(2)O = myo-inositol 1,4-bisphosphate + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
1D-myo-inositol 1,3,4,5-tetrakisphosphate + H(2)O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate.
UniProtKB/Swiss-Prot Function:
Major isoenzyme hydrolyzing the calcium-mobilizing second messenger Ins(1,4,5)P3, this is a signal-terminating reaction.

Enzyme Numbers (IUBMB) for INPP5A Gene

Gene Ontology (GO) - Molecular Function for INPP5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004445 inositol-polyphosphate 5-phosphatase activity NAS 8006039
GO:0016787 hydrolase activity IEA --
GO:0042731 PH domain binding IPI 8999861
GO:0052659 inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity IEA --
genes like me logo Genes that share ontologies with INPP5A: view
genes like me logo Genes that share phenotypes with INPP5A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for INPP5A

miRNA for INPP5A Gene

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for INPP5A Gene

Localization for INPP5A Gene

Subcellular locations from UniProtKB/Swiss-Prot for INPP5A Gene

Membrane; Lipid-anchor.

Subcellular locations from

Jensen Localization Image for INPP5A Gene COMPARTMENTS Subcellular localization image for INPP5A gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 3
cytoskeleton 1
endosome 1
golgi apparatus 1
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for INPP5A Gene

Pathways & Interactions for INPP5A Gene

genes like me logo Genes that share pathways with INPP5A: view

Gene Ontology (GO) - Biological Process for INPP5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043647 inositol phosphate metabolic process TAS --
genes like me logo Genes that share ontologies with INPP5A: view

No data available for SIGNOR curated interactions for INPP5A Gene

Drugs & Compounds for INPP5A Gene

(2) Drugs for INPP5A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
D-Myo-Inositol-1,4-Bisphosphate Experimental Pharma 0
calcium Nutra 0

(8) Additional Compounds for INPP5A Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Inositol 1,3,4,5-tetraphosphate
  • 1,3,4,5-Tetrakis(dihydrogen phosphate) myo-Inositol
  • 1D-Myo-inositol 1,3,4,5-tetrakis(dihydrogen phosphate)
  • 1D-Myo-inositol 1,3,4,5-tetrakisphosphate
  • D-Myo-inositol 1,3,4,5-tetrakisphosphate
  • Inositol 1,3,4,5-tetrakis(phosphate)
Inositol 1,3,4-trisphosphate
  • 1,3,4-Itp
  • 1D-Myo-Inositol 1,3,4-trisphosphate
  • D-Myo-Inositol 1,3,4-trisphosphate
  • I3S
  • Inositol 1,3,4-triphosphate
Inositol 1,4,5-trisphosphate
  • 1D-Myo-Inositol 1,4,5-trisphosphate
  • D-Myo-Inositol 1,4,5-trisphosphate
  • Inositol 1,4,5-trisphosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
genes like me logo Genes that share compounds with INPP5A: view

Transcripts for INPP5A Gene

Unigene Clusters for INPP5A Gene

Inositol polyphosphate-5-phosphatase, 40kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for INPP5A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16
SP1: -
SP3: - - -

Relevant External Links for INPP5A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for INPP5A Gene

mRNA expression in normal human tissues for INPP5A Gene

Protein differential expression in normal tissues from HIPED for INPP5A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.9), Breast (14.3), and Frontal cortex (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for INPP5A Gene

SOURCE GeneReport for Unigene cluster for INPP5A Gene Hs.523360

mRNA Expression by UniProt/SwissProt for INPP5A Gene

Tissue specificity: Brain; high level in Purkinje cells.
genes like me logo Genes that share expression patterns with INPP5A: view

Protein tissue co-expression partners for INPP5A Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for INPP5A Gene

Orthologs for INPP5A Gene

This gene was present in the common ancestor of animals.

Orthologs for INPP5A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia INPP5A 35
  • 87.57 (n)
  • 95.03 (a)
  • 95 (a)
(Canis familiaris)
Mammalia INPP5A 35
  • 90.7 (n)
  • 96.6 (a)
  • 96 (a)
(Mus musculus)
Mammalia Inpp5a 35
  • 90.21 (n)
  • 97.09 (a)
Inpp5a 16
Inpp5a 36
  • 92 (a)
(Pan troglodytes)
Mammalia INPP5A 35
  • 99.6 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Inpp5a 35
  • 90.21 (n)
  • 97.09 (a)
(Monodelphis domestica)
Mammalia INPP5A 36
  • 50 (a)
(Ornithorhynchus anatinus)
Mammalia INPP5A 36
  • 83 (a)
(Gallus gallus)
Aves INPP5A 35
  • 82.36 (n)
  • 92.11 (a)
  • 91 (a)
(Anolis carolinensis)
Reptilia INPP5A 36
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia inpp5a.1 35
  • 77.43 (n)
  • 83.74 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8191 35
(Danio rerio)
Actinopterygii zgc:123248 35
  • 61.27 (n)
  • 55.35 (a)
  • 74 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000203 35
  • 56.28 (n)
  • 50.79 (a)
fruit fly
(Drosophila melanogaster)
Insecta 5PtaseI 35
  • 53.66 (n)
  • 47.55 (a)
5PtaseI 36
  • 24 (a)
(Caenorhabditis elegans)
Secernentea ipp-5 35
  • 49.64 (n)
  • 43.01 (a)
C01B10.3 36
  • 21 (a)
ipp-5 36
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2673 36
  • 38 (a)
Species with no ortholog for INPP5A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for INPP5A Gene

Gene Tree for INPP5A (if available)
Gene Tree for INPP5A (if available)

Paralogs for INPP5A Gene

No data available for Paralogs for INPP5A Gene

Variants for INPP5A Gene

Sequence variations from dbSNP and Humsavar for INPP5A Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1133400 - 132,645,884(+) ACACA(A/G)GCCGC nc-transcript-variant, reference, missense
rs1543593 -- 132,739,681(-) ACGTG(A/T)GCAGC intron-variant
rs1548281 -- 132,739,478(-) GGCTC(A/C/G)ACAGG intron-variant
rs1571145 -- 132,770,168(+) AGCGT(C/G)CCCCT intron-variant
rs2986542 -- 132,772,452(+) GCCAC(A/G)GCAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for INPP5A Gene

Variant ID Type Subtype PubMed ID
nsv896122 CNV Loss 21882294
nsv896149 CNV Loss 21882294
nsv896151 CNV Loss 21882294
nsv896161 CNV Loss 21882294
dgv326e1 CNV Complex 17122850
nsv896170 CNV Loss 21882294
nsv509376 CNV Insertion 20534489
dgv849n71 CNV Loss 21882294
esv2676009 CNV Deletion 23128226
esv2743694 CNV Deletion 23290073
esv25225 CNV Gain 19812545
esv2743695 CNV Deletion 23290073
nsv25372 CNV Loss 16902084
esv2743698 CNV Deletion 23290073
esv2743699 CNV Deletion 23290073
esv999432 CNV Deletion 20482838
esv1277422 CNV Deletion 17803354
esv1043694 CNV Deletion 17803354
esv2743700 CNV Deletion 23290073
nsv24819 CNV Insertion 16902084
nsv896174 CNV Gain 21882294
esv2743701 CNV Deletion 23290073
dgv850n71 CNV Loss 21882294
dgv851n71 CNV Loss 21882294
dgv852n71 CNV Loss 21882294
esv2743702 CNV Deletion 23290073
esv2743703 CNV Deletion 23290073
nsv509377 CNV Insertion 20534489
esv28015 CNV Gain 19812545
esv2743704 CNV Deletion 23290073
nsv7628 CNV Insertion 18451855
esv2743705 CNV Deletion 23290073
esv28744 CNV Loss 19812545
nsv821276 CNV Deletion 20802225
esv2743706 CNV Deletion 23290073
esv2743707 CNV Deletion 23290073
esv2743709 CNV Deletion 23290073
nsv896182 CNV Loss 21882294
nsv832032 CNV Loss 17160897
esv2743710 CNV Deletion 23290073
nsv896183 CNV Loss 21882294
nsv896184 CNV Loss 21882294
esv2743711 CNV Deletion 23290073
esv1471684 CNV Insertion 17803354
nsv470977 CNV Loss 18288195
esv2743712 CNV Deletion 23290073
esv1003188 CNV Deletion 20482838
esv1681558 CNV Deletion 17803354
dgv853n71 CNV Loss 21882294
nsv896187 CNV Loss 21882294
nsv896189 CNV Gain 21882294
nsv509378 CNV Insertion 20534489
nsv467496 CNV Gain 19166990
esv2743713 CNV Deletion 23290073
dgv854n71 CNV Loss 21882294
nsv896194 CNV Loss 21882294
esv2274837 CNV Deletion 18987734
nsv24809 CNV Loss 16902084
nsv24773 CNV Loss 16902084
esv1314079 CNV Insertion 17803354
esv2743714 CNV Deletion 23290073
nsv832033 CNV Loss 17160897
dgv855n71 CNV Loss 21882294
esv998279 CNV Deletion 20482838
dgv856n71 CNV Loss 21882294
esv2743715 CNV Deletion 23290073
esv992316 CNV Deletion 20482838
esv1420103 CNV Deletion 17803354
esv2743716 CNV Deletion 23290073
esv1507539 CNV Deletion 17803354
nsv832034 CNV Loss 17160897
esv2743717 CNV Deletion 23290073
esv2657781 CNV Deletion 23128226
esv2743718 CNV Deletion 23290073
dgv137e201 CNV Deletion 23290073
dgv183n67 CNV Gain 20364138
esv2743720 CNV Deletion 23290073
esv1685428 CNV Insertion 17803354
esv2743721 CNV Deletion 23290073
esv2619584 CNV Deletion 19546169
esv2743722 CNV Deletion 23290073
esv28959 CNV Gain+Loss 19812545
nsv820457 CNV Deletion 20802225
nsv25414 CNV Loss 16902084
esv1199957 CNV Deletion 17803354
esv2743723 CNV Deletion 23290073
esv1197964 CNV Deletion 17803354
dgv138e201 CNV Deletion 23290073
esv2743725 CNV Deletion 23290073
nsv25439 CNV Loss 16902084
esv1579193 CNV Deletion 17803354
esv2743727 CNV Deletion 23290073
dgv857n71 CNV Loss 21882294
dgv858n71 CNV Loss 21882294
dgv859n71 CNV Loss 21882294
esv1531275 CNV Insertion 17803354
esv2743728 CNV Deletion 23290073
nsv513303 CNV Insertion 21212237
esv2743729 CNV Deletion 23290073
nsv825660 CNV Gain 20364138
nsv896205 CNV Loss 21882294
dgv184n67 CNV Gain 20364138
nsv825663 CNV Gain 20364138

Variation tolerance for INPP5A Gene

Residual Variation Intolerance Score: 43.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.46; 82.05% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for INPP5A Gene

Disorders for INPP5A Gene

MalaCards: The human disease database

(2) MalaCards diseases for INPP5A Gene - From: DISEASES

Disorder Aliases PubMed IDs
x-linked disease
joubert syndrome 1
  • joubert syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for INPP5A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with INPP5A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for INPP5A Gene

Publications for INPP5A Gene

  1. Cloning and expression of human brain type I inositol 1,4,5- trisphosphate 5-phosphatase. High levels of mRNA in cerebellar Purkinje cells. (PMID: 8013665) de Smedt F. … Erneux C. (FEBS Lett. 1994) 2 3 4 23 67
  2. Chromosomal mapping of the gene (INPP5A) encoding the 43-kDa membrane-associated inositol polyphosphate 5-phosphatase to 10q26.3 by fluorescence in situ hybridization. (PMID: 8808294) Mitchell C.A. … Sutherland G.R. (Genomics 1996) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  5. Exome sequencing supports a de novo mutational paradigm for schizophrenia. (PMID: 21822266) Xu B. … Karayiorgou M. (Nat. Genet. 2011) 3

Products for INPP5A Gene

Sources for INPP5A Gene