Free for academic non-profit institutions. Other users need a Commercial license

Aliases for INPP5A Gene

Aliases for INPP5A Gene

  • Inositol Polyphosphate-5-Phosphatase, 40kDa 2 3
  • Type I Inositol-1,4,5-Trisphosphate 5-Phosphatase 2 3
  • 43 KDa Inositol Polyphosphate 5-Phophatase 2 3
  • Inositol Polyphosphate-5-Phosphatase, 40kD 2 3
  • CTCL Tumor Antigen HD-CL-02 2 3
  • InsP3 5-Phosphatase 2 3
  • 5PTASE 3 4
  • Type I Inositol 1,4,5-Trisphosphate 5-Phosphatase 3
  • Type I Inositol-1,4,5-Trisphosphate 5-Phophatase 3
  • Inositol Trisphosphate-5-Phosphatase, 40kD 3
  • Inositol Polyphosphate 5-Phophatase 2
  • EC 3.1.3.56 4
  • 40kDa 2

External Ids for INPP5A Gene

Summaries for INPP5A Gene

Entrez Gene Summary for INPP5A Gene

  • The protein encoded by this gene is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. [provided by RefSeq, Jul 2008]

GeneCards Summary for INPP5A Gene

INPP5A (Inositol Polyphosphate-5-Phosphatase, 40kDa) is a Protein Coding gene. Diseases associated with INPP5A include oculocerebrorenal syndrome. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include inositol-polyphosphate 5-phosphatase activity and inositol-1,4,5-trisphosphate 5-phosphatase activity.

UniProtKB/Swiss-Prot for INPP5A Gene

  • Major isoenzyme hydrolyzing the calcium-mobilizing second messenger Ins(1,4,5)P3, this is a signal-terminating reaction

Gene Wiki entry for INPP5A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INPP5A Gene

Genomics for INPP5A Gene

Genomic Location for INPP5A Gene

Start:
132,537,820 bp from pter
End:
132,783,480 bp from pter
Size:
245,661 bases
Orientation:
Plus strand

Genomic View for INPP5A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for INPP5A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INPP5A Gene

Regulatory Elements for INPP5A Gene

Proteins for INPP5A Gene

  • Protein details for INPP5A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14642-I5P1_HUMAN
    Recommended name:
    Type I inositol 1,4,5-trisphosphate 5-phosphatase
    Protein Accession:
    Q14642
    Secondary Accessions:
    • D3DXI3
    • Q14640
    • Q5JSF1

    Protein attributes for INPP5A Gene

    Size:
    412 amino acids
    Molecular mass:
    47820 Da
    Quaternary structure:
    No Data Available

neXtProt entry for INPP5A Gene

Proteomics data for INPP5A Gene at MOPED

Post-translational modifications for INPP5A Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys73, Lys265, Lys284, Lys307, and Lys358

Other Protein References for INPP5A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for INPP5A Gene

Domains for INPP5A Gene

Gene Families for INPP5A Gene

Protein Domains for INPP5A Gene

UniProtKB/Swiss-Prot:

I5P1_HUMAN
Family:
  • Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type I family.:
    • Q14642
genes like me logo Genes that share domains with INPP5A: view

Function for INPP5A Gene

Molecular function for INPP5A Gene

GENATLAS Biochemistry: inositol 1,4,5-triphosphate 5-phosphatase (43kDa) membrane-associated,predominantly expressed in heart,brain,skeletal,muscle,signal terminating reaction in the inositol signaling pathway
UniProtKB/Swiss-Prot CatalyticActivity: D-myo-inositol 1,4,5-trisphosphate + H(2)O = myo-inositol 1,4-bisphosphate + phosphate
UniProtKB/Swiss-Prot CatalyticActivity: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H(2)O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate
UniProtKB/Swiss-Prot Function: Major isoenzyme hydrolyzing the calcium-mobilizing second messenger Ins(1,4,5)P3, this is a signal-terminating reaction

Enzyme Numbers (IUBMB) for INPP5A Gene

Gene Ontology (GO) - Molecular Function for INPP5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004445 inositol-polyphosphate 5-phosphatase activity NAS 8006039
GO:0005515 protein binding IPI 8999861
GO:0042731 PH domain binding IPI 8999861
GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity IEA --
GO:0052659 inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity IEA --
genes like me logo Genes that share ontologies with INPP5A: view

Phenotypes for INPP5A Gene

MGI mutant phenotypes for INPP5A:
inferred from 1 alleles
GenomeRNAi human phenotypes for INPP5A:
genes like me logo Genes that share phenotypes with INPP5A: view

miRNA for INPP5A Gene

miRTarBase miRNAs that target INPP5A

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for INPP5A Gene

Localization for INPP5A Gene

Subcellular locations from UniProtKB/Swiss-Prot for INPP5A Gene

Membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for INPP5A Gene COMPARTMENTS Subcellular localization image for INPP5A gene
Compartment Confidence
plasma membrane 4
cytosol 3
extracellular 2
cytoskeleton 1
endosome 1
golgi apparatus 1
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for INPP5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane NAS 8006039
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with INPP5A: view

Pathways for INPP5A Gene

genes like me logo Genes that share pathways with INPP5A: view

Gene Ontology (GO) - Biological Process for INPP5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043647 inositol phosphate metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0046856 phosphatidylinositol dephosphorylation IEA --
genes like me logo Genes that share ontologies with INPP5A: view

Compounds for INPP5A Gene

(7) HMDB Compounds for INPP5A Gene

Compound Synonyms Cas Number PubMed IDs
1D-Myo-inositol 1,4-bisphosphate
  • 1D-Myo-inositol 1,4-bisphosphate
47055-78-7
Calcium
  • Ca
7440-70-2
Inositol 1,3,4,5-tetraphosphate
  • 1,3,4,5-tetrakis(dihydrogen phosphate) myo-Inositol
102850-29-3
Inositol 1,3,4-trisphosphate
  • 1,3,4-Itp
98102-63-7
Inositol 1,4,5-trisphosphate
  • 1D-myo-Inositol 1,4,5-trisphosphate
88269-39-0

(2) Novoseek inferred chemical compound relationships for INPP5A Gene

Compound -log(P) Hits PubMed IDs
inositol 1,4-bisphosphate 90.3 3
inositol 1,4,5 trisphosphate 79.2 12
genes like me logo Genes that share compounds with INPP5A: view

Transcripts for INPP5A Gene

Unigene Clusters for INPP5A Gene

Inositol polyphosphate-5-phosphatase, 40kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for INPP5A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16
SP1: -
SP2:
SP3: - - -

Relevant External Links for INPP5A Gene

GeneLoc Exon Structure for
INPP5A
ECgene alternative splicing isoforms for
INPP5A

Expression for INPP5A Gene

mRNA expression in normal human tissues for INPP5A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for INPP5A Gene

SOURCE GeneReport for Unigene cluster for INPP5A Gene Hs.523360

mRNA Expression by UniProt/SwissProt for INPP5A Gene

Q14642-I5P1_HUMAN
Tissue specificity: Brain; high level in Purkinje cells
genes like me logo Genes that share expressions with INPP5A: view

Orthologs for INPP5A Gene

This gene was present in the common ancestor of animals.

Orthologs for INPP5A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INPP5A 36
  • 99.6 (n)
  • 100 (a)
INPP5A 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia INPP5A 36
  • 87.57 (n)
  • 95.03 (a)
INPP5A 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia INPP5A 36
  • 90.7 (n)
  • 96.6 (a)
INPP5A 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Inpp5a 36
  • 90.21 (n)
  • 97.09 (a)
Inpp5a 16
Inpp5a 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia INPP5A 37
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia INPP5A 37
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Inpp5a 36
  • 90.21 (n)
  • 97.09 (a)
chicken
(Gallus gallus)
Aves INPP5A 36
  • 82.36 (n)
  • 92.11 (a)
INPP5A 37
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia INPP5A 37
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8191 36
tropical clawed frog
(Silurana tropicalis)
Amphibia inpp5a.1 36
  • 77.43 (n)
  • 83.74 (a)
zebrafish
(Danio rerio)
Actinopterygii INPP5A 37
  • 74 (a)
OneToOne
zgc:123248 36
  • 61.27 (n)
  • 55.35 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000203 36
  • 56.28 (n)
  • 50.79 (a)
fruit fly
(Drosophila melanogaster)
Insecta 5PtaseI 36
  • 53.66 (n)
  • 47.55 (a)
5PtaseI 37
  • 24 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C01B10.3 37
  • 21 (a)
OneToMany
ipp-5 36
  • 49.64 (n)
  • 43.01 (a)
ipp-5 37
  • 37 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2673 37
  • 38 (a)
OneToOne
Species with no ortholog for INPP5A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for INPP5A Gene

ENSEMBL:
Gene Tree for INPP5A (if available)
TreeFam:
Gene Tree for INPP5A (if available)

Paralogs for INPP5A Gene

No data available for Paralogs for INPP5A Gene

Variants for INPP5A Gene

Sequence variations from dbSNP and Humsavar for INPP5A Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs745352 -- 132,722,484(-) CACGG(G/T)GACAG intron-variant
rs753632 -- 132,731,265(+) CCTGC(A/G)TATCA intron-variant
rs873946 -- 132,716,468(+) GACGT(C/T)TCCAC intron-variant
rs913189 -- 132,761,097(+) GCTTC(A/G)TGCCA intron-variant
rs913192 -- 132,731,395(-) TTCCA(A/G)GGGCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for INPP5A Gene

Variant ID Type Subtype PubMed ID
nsv896122 CNV Loss 21882294
nsv896149 CNV Loss 21882294
nsv896151 CNV Loss 21882294
nsv896161 CNV Loss 21882294
dgv326e1 CNV Complex 17122850
nsv896170 CNV Loss 21882294
nsv509376 CNV Insertion 20534489
dgv849n71 CNV Loss 21882294
esv2676009 CNV Deletion 23128226
esv2743694 CNV Deletion 23290073
esv25225 CNV Gain 19812545
esv2743695 CNV Deletion 23290073
nsv25372 CNV Loss 16902084
esv2743698 CNV Deletion 23290073
esv2743699 CNV Deletion 23290073
esv999432 CNV Deletion 20482838
esv1277422 CNV Deletion 17803354
esv1043694 CNV Deletion 17803354
esv2743700 CNV Deletion 23290073
nsv24819 CNV Insertion 16902084
nsv896174 CNV Gain 21882294
esv2743701 CNV Deletion 23290073
dgv850n71 CNV Loss 21882294
dgv851n71 CNV Loss 21882294
dgv852n71 CNV Loss 21882294
esv2743702 CNV Deletion 23290073
esv2743703 CNV Deletion 23290073
nsv509377 CNV Insertion 20534489
esv28015 CNV Gain 19812545
esv2743704 CNV Deletion 23290073
nsv7628 CNV Insertion 18451855
esv2743705 CNV Deletion 23290073
esv28744 CNV Loss 19812545
nsv821276 CNV Deletion 20802225
esv2743706 CNV Deletion 23290073
esv2743707 CNV Deletion 23290073
esv2743709 CNV Deletion 23290073
nsv896182 CNV Loss 21882294
nsv832032 CNV Loss 17160897
esv2743710 CNV Deletion 23290073
nsv896183 CNV Loss 21882294
nsv896184 CNV Loss 21882294
esv2743711 CNV Deletion 23290073
esv1471684 CNV Insertion 17803354
nsv470977 CNV Loss 18288195
esv2743712 CNV Deletion 23290073
esv1003188 CNV Deletion 20482838
esv1681558 CNV Deletion 17803354
dgv853n71 CNV Loss 21882294
nsv896187 CNV Loss 21882294
nsv896189 CNV Gain 21882294
nsv509378 CNV Insertion 20534489
nsv467496 CNV Gain 19166990
esv2743713 CNV Deletion 23290073
dgv854n71 CNV Loss 21882294
nsv896194 CNV Loss 21882294
esv2274837 CNV Deletion 18987734
nsv24809 CNV Loss 16902084
nsv24773 CNV Loss 16902084
esv1314079 CNV Insertion 17803354
esv2743714 CNV Deletion 23290073
nsv832033 CNV Loss 17160897
dgv855n71 CNV Loss 21882294
esv998279 CNV Deletion 20482838
dgv856n71 CNV Loss 21882294
esv2743715 CNV Deletion 23290073
esv992316 CNV Deletion 20482838
esv1420103 CNV Deletion 17803354
esv2743716 CNV Deletion 23290073
esv1507539 CNV Deletion 17803354
nsv832034 CNV Loss 17160897
esv2743717 CNV Deletion 23290073
esv2657781 CNV Deletion 23128226
esv2743718 CNV Deletion 23290073
dgv137e201 CNV Deletion 23290073
dgv183n67 CNV Gain 20364138
esv2743720 CNV Deletion 23290073
esv1685428 CNV Insertion 17803354
esv2743721 CNV Deletion 23290073
esv2619584 CNV Deletion 19546169
esv2743722 CNV Deletion 23290073
esv28959 CNV Gain+Loss 19812545
nsv820457 CNV Deletion 20802225
nsv25414 CNV Loss 16902084
esv1199957 CNV Deletion 17803354
esv2743723 CNV Deletion 23290073
esv1197964 CNV Deletion 17803354
dgv138e201 CNV Deletion 23290073
esv2743725 CNV Deletion 23290073
nsv25439 CNV Loss 16902084
esv1579193 CNV Deletion 17803354
esv2743727 CNV Deletion 23290073
dgv857n71 CNV Loss 21882294
dgv858n71 CNV Loss 21882294
dgv859n71 CNV Loss 21882294
esv1531275 CNV Insertion 17803354
esv2743728 CNV Deletion 23290073
nsv513303 CNV Insertion 21212237
esv2743729 CNV Deletion 23290073
nsv825660 CNV Gain 20364138
nsv896205 CNV Loss 21882294
dgv184n67 CNV Gain 20364138
nsv825663 CNV Gain 20364138

Relevant External Links for INPP5A Gene

HapMap Linkage Disequilibrium report
INPP5A

Disorders for INPP5A Gene

(2) University of Copenhagen DISEASES for INPP5A Gene

genes like me logo Genes that share disorders with INPP5A: view

No data available for UniProtKB/Swiss-Prot for INPP5A Gene

Publications for INPP5A Gene

  1. Cloning and expression of human brain type I inositol 1,4,5- trisphosphate 5-phosphatase. High levels of mRNA in cerebellar Purkinje cells. (PMID: 8013665) de Smedt F. … Erneux C. (FEBS Lett. 1994) 2 3 4 23
  2. Chromosomal mapping of the gene (INPP5A) encoding the 43-kDa membrane-associated inositol polyphosphate 5-phosphatase to 10q26.3 by fluorescence in situ hybridization. (PMID: 8808294) Mitchell C.A. … Sutherland G.R. (Genomics 1996) 3 23
  3. Characterization of a cDNA encoding the 43-kDa membrane-associated inositol-polyphosphate 5-phosphatase. (PMID: 8006039) Laxminarayan K.M. … Mitchell C.A. (J. Biol. Chem. 1994) 3 4
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for INPP5A Gene

Sources for INPP5A Gene

Back to Top

Content