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Aliases for INPP4B Gene

Aliases for INPP4B Gene

  • Inositol Polyphosphate-4-Phosphatase Type II B 2 3 5
  • EC 4 63
  • Inositol Polyphosphate-4-Phosphatase, Type II, 105kDa 2
  • Inositol Polyphosphate-4-Phosphatase, Type II, 105kD 2
  • Inositol Polyphosphate 4-Phosphatase Type II 4

External Ids for INPP4B Gene

Previous GeneCards Identifiers for INPP4B Gene

  • GC04M143812
  • GC04M143266
  • GC04M143415
  • GC04M143527
  • GC04M143526
  • GC04M143306
  • GC04M142949
  • GC04M138678

Summaries for INPP4B Gene

Entrez Gene Summary for INPP4B Gene

  • INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate. There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme. [provided by RefSeq, Jul 2008]

GeneCards Summary for INPP4B Gene

INPP4B (Inositol Polyphosphate-4-Phosphatase Type II B) is a Protein Coding gene. Among its related pathways are Inositol phosphate metabolism (REACTOME) and Ca, cAMP and Lipid Signaling. GO annotations related to this gene include lipid binding and phosphatidylinositol trisphosphate phosphatase activity. An important paralog of this gene is INPP4A.

UniProtKB/Swiss-Prot for INPP4B Gene

  • Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INPP4B Gene

Genomics for INPP4B Gene

Regulatory Elements for INPP4B Gene

Enhancers for INPP4B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around INPP4B on UCSC Golden Path with GeneCards custom track

Promoters for INPP4B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around INPP4B on UCSC Golden Path with GeneCards custom track

Genomic Location for INPP4B Gene

142,023,160 bp from pter
142,847,432 bp from pter
824,273 bases
Minus strand

Genomic View for INPP4B Gene

Genes around INPP4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INPP4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INPP4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INPP4B Gene

Proteins for INPP4B Gene

  • Protein details for INPP4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Type II inositol 3,4-bisphosphate 4-phosphatase
    Protein Accession:
    Secondary Accessions:
    • Q2TAI2
    • Q5XLE7
    • Q6IN59
    • Q6PJB4

    Protein attributes for INPP4B Gene

    924 amino acids
    Molecular mass:
    104738 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH72447.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for INPP4B Gene


neXtProt entry for INPP4B Gene

Proteomics data for INPP4B Gene at MOPED

Post-translational modifications for INPP4B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for INPP4B (INPP4B)

Domains & Families for INPP4B Gene

Gene Families for INPP4B Gene

Protein Domains for INPP4B Gene

Suggested Antigen Peptide Sequences for INPP4B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C2 domain.
  • Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.
  • Contains 1 C2 domain.
  • Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.
genes like me logo Genes that share domains with INPP4B: view

Function for INPP4B Gene

Molecular function for INPP4B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
1-phosphatidyl-myo-inositol 3,4-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Strongly inhibited by inositol hexakisphosphate.
UniProtKB/Swiss-Prot Function:
Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate.

Enzyme Numbers (IUBMB) for INPP4B Gene

Gene Ontology (GO) - Molecular Function for INPP4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24407287
genes like me logo Genes that share ontologies with INPP4B: view
genes like me logo Genes that share phenotypes with INPP4B: view

Animal Models for INPP4B Gene

MGI Knock Outs for INPP4B:

Animal Model Products

miRNA for INPP4B Gene

miRTarBase miRNAs that target INPP4B

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for INPP4B Gene

Localization for INPP4B Gene

Subcellular locations from

Jensen Localization Image for INPP4B Gene COMPARTMENTS Subcellular localization image for INPP4B gene
Compartment Confidence
cytosol 5
cytoskeleton 3
nucleus 2
endosome 1
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for INPP4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with INPP4B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for INPP4B Gene

Pathways & Interactions for INPP4B Gene

genes like me logo Genes that share pathways with INPP4B: view

Pathways by source for INPP4B Gene

UniProtKB/Swiss-Prot O15327-INP4B_HUMAN

  • Pathway: Signal transduction; phosphatidylinositol signaling pathway.

Interacting Proteins for INPP4B Gene

Gene Ontology (GO) - Biological Process for INPP4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process TAS --
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IEA,TAS --
GO:0043647 inositol phosphate metabolic process TAS --
genes like me logo Genes that share ontologies with INPP4B: view

No data available for SIGNOR curated interactions for INPP4B Gene

Drugs & Compounds for INPP4B Gene

(7) Additional Compounds for INPP4B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1D-Myo-inositol 3,4-bisphosphate
  • 1D-Myo-inositol 3,4-bis(dihydrogen phosphate)
  • D-Myo-Inositol 3,4-bisphosphate
  • Inositol 3,4-bisphosphate
1D-myo-Inositol 3-phosphate
  • 1D-Myo-Inositol 3-monophosphate
  • 1L-Myo-Inositol 1-phosphate
  • D-Myo-Inositol 3-monophosphate
  • D-Myo-Inositol 3-phosphate
  • Inositol 3-monophosphate
1-Phosphatidyl-1D-myo-inositol 3-phosphate
  • 1-Phosphatidyl-1D-myo-inositol 3-phosphate
  • Phosphatidylinositol 3-phosphate
Myo-inositol 1-phosphate
  • 1-(Dihydrogen phosphate) DL-myo-Inositol
  • 1-(Dihydrogen phosphate) myo-Inositol
  • DL-myo-Inositol 1-phosphate
  • Myo-Inositol 1-monophosphate
  • Myo-Inositol 1-phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
genes like me logo Genes that share compounds with INPP4B: view

Transcripts for INPP4B Gene

Unigene Clusters for INPP4B Gene

Inositol polyphosphate-4-phosphatase, type II, 105kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for INPP4B Gene

No ASD Table

Relevant External Links for INPP4B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for INPP4B Gene

mRNA expression in normal human tissues for INPP4B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for INPP4B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.1), Bone (10.7), Lung (8.9), and Breast (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for INPP4B Gene

SOURCE GeneReport for Unigene cluster for INPP4B Gene Hs.531403

mRNA Expression by UniProt/SwissProt for INPP4B Gene

Tissue specificity: Widely expressed with highest levels occurring in the skeletal muscle and heart.
genes like me logo Genes that share expression patterns with INPP4B: view

Protein tissue co-expression partners for INPP4B Gene

Primer Products

No data available for mRNA differential expression in normal tissues for INPP4B Gene

Orthologs for INPP4B Gene

This gene was present in the common ancestor of animals.

Orthologs for INPP4B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia INPP4B 35
  • 91.41 (n)
  • 93.61 (a)
  • 93 (a)
(Canis familiaris)
Mammalia INPP4B 35
  • 87.48 (n)
  • 89.61 (a)
  • 84 (a)
(Mus musculus)
Mammalia Inpp4b 35
  • 86.83 (n)
  • 90.73 (a)
Inpp4b 16
Inpp4b 36
  • 85 (a)
(Pan troglodytes)
Mammalia INPP4B 35
  • 99.6 (n)
  • 99.68 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Inpp4b 35
  • 85.61 (n)
  • 90.57 (a)
(Monodelphis domestica)
Mammalia INPP4B 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia INPP4B 36
  • 78 (a)
(Gallus gallus)
Aves INPP4B 35
  • 79.16 (n)
  • 80.61 (a)
  • 80 (a)
(Anolis carolinensis)
Reptilia INPP4B 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia inpp4b 35
  • 72.52 (n)
  • 70.67 (a)
(Danio rerio)
Actinopterygii Dr.22355 35
inpp4b 35
  • 62.31 (n)
  • 62.14 (a)
inpp4b 36
  • 59 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2969 35
fruit fly
(Drosophila melanogaster)
Insecta CG1846 37
  • 35 (a)
CG42271 36
  • 21 (a)
(Caenorhabditis elegans)
Secernentea R01H10.7 36
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
Species with no ortholog for INPP4B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for INPP4B Gene

Gene Tree for INPP4B (if available)
Gene Tree for INPP4B (if available)

Paralogs for INPP4B Gene

Paralogs for INPP4B Gene

genes like me logo Genes that share paralogs with INPP4B: view

Variants for INPP4B Gene

Sequence variations from dbSNP and Humsavar for INPP4B Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1064226 - 142,208,931(-) TATGT(A/T)CCAAG nc-transcript-variant, reference, missense
rs167960 -- 142,738,081(-) aaatg(C/G)tattt intron-variant
rs168013 -- 142,335,033(-) TCTTA(A/G)AAGGC intron-variant
rs168014 -- 142,473,269(-) gctca(A/G)atgat intron-variant
rs168015 -- 142,405,385(+) AACTT(C/T)TGCGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for INPP4B Gene

Variant ID Type Subtype PubMed ID
nsv830096 CNV Gain 17160897
nsv830097 CNV Gain 17160897
esv2728453 CNV Deletion 23290073
esv2728454 CNV Deletion 23290073
esv2728455 CNV Deletion 23290073
esv2728456 CNV Deletion 23290073
esv2728457 CNV Deletion 23290073
esv2674465 CNV Deletion 23128226
dgv897e201 CNV Deletion 23290073
esv2728459 CNV Deletion 23290073
esv2728461 CNV Deletion 23290073
esv2728463 CNV Deletion 23290073
esv1010249 CNV Deletion 20482838
nsv830098 CNV Gain 17160897
esv2728464 CNV Deletion 23290073
esv989976 CNV Deletion 20482838
nsv830099 CNV Gain 17160897
esv2728465 CNV Deletion 23290073
esv2256713 CNV Deletion 18987734
esv2728466 CNV Deletion 23290073
esv1561602 CNV Deletion 17803354
esv259589 OTHER Complex 20981092
esv259840 OTHER Complex 20981092
nsv292962 CNV Insertion 16902084
nsv830100 CNV Gain 17160897
esv269532 CNV Insertion 20981092
esv274584 CNV Insertion 20981092
nsv292161 CNV Loss 16902084
esv2675652 CNV Deletion 23128226
nsv461660 CNV Gain 19166990
esv2728467 CNV Deletion 23290073
esv2728468 CNV Deletion 23290073
esv2279055 CNV Deletion 18987734
esv4656 CNV Deletion 18987735
nsv292163 CNV Loss 16902084
esv997092 CNV Deletion 20482838
esv2728469 CNV Deletion 23290073
esv1151116 CNV Deletion 17803354
nsv292381 CNV Loss 16902084
nsv830101 CNV Loss 17160897
nsv441917 CNV CNV 18776908
esv2677141 CNV Deletion 23128226
esv21478 CNV Loss 19812545
nsv880174 CNV Loss 21882294
esv2659841 CNV Deletion 23128226
esv2728470 CNV Deletion 23290073
nsv292010 CNV Loss 16902084
nsv509937 CNV Loss 20534489

Variation tolerance for INPP4B Gene

Residual Variation Intolerance Score: 8.97% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.17; 39.25% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for INPP4B Gene

Disorders for INPP4B Gene

Relevant External Links for INPP4B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for INPP4B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for INPP4B Gene

Publications for INPP4B Gene

  1. The cDNA cloning and characterization of inositol polyphosphate 4- phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family. (PMID: 9295334) Norris F.A. … Majerus P.W. (J. Biol. Chem. 1997) 2 3 4 23 67
  2. Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling. (PMID: 19647222) Gewinner C. … Cantley L.C. (Cancer Cell 2009) 3 23
  3. INPP4B is highly expressed in prostate intermediate cells and its loss of expression in prostate carcinoma predicts for recurrence and poor long term survival. (PMID: 25284366) Rynkiewicz N.K. … Mitchell C.A. (Prostate 2015) 3
  4. INPP4B and RAD50 have an interactive effect on survival after breast cancer. (PMID: 25528023) Dai X. … Nevanlinna H. (Breast Cancer Res. Treat. 2015) 3
  5. INPP4B overexpression is associated with poor clinical outcome and therapy resistance in acute myeloid leukemia. (PMID: 25736236) Dzneladze I. … Salmena L. (Leukemia 2015) 3

Products for INPP4B Gene

Sources for INPP4B Gene