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Aliases for INPP4A Gene

Aliases for INPP4A Gene

  • Inositol Polyphosphate-4-Phosphatase Type I A 2 3 5
  • Inositol Polyphosphate-4-Phosphatase, Type I, 107kDa 2 3
  • Inositol Polyphosphate-4-Phosphatase, Type I, 107kD 2 3
  • EC 4 63
  • Type I Inositol-3,4-Bisphosphate 4-Phosphatase 3
  • Inositol Polyphosphate 4-Phosphatase Type I 4
  • TVAS1 3
  • INPP4 3

External Ids for INPP4A Gene

Previous HGNC Symbols for INPP4A Gene

  • INPP4

Previous GeneCards Identifiers for INPP4A Gene

  • GC02P097017
  • GC02P097513
  • GC02P098665
  • GC02P098682
  • GC02P099061
  • GC02P092826

Summaries for INPP4A Gene

Entrez Gene Summary for INPP4A Gene

  • This gene encodes an Mg++ independent enzyme that hydrolyzes the 4-position phosphate from the inositol ring of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate, and inositol 3,4-bisphosphate. Multiple transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Aug 2008]

GeneCards Summary for INPP4A Gene

INPP4A (Inositol Polyphosphate-4-Phosphatase Type I A) is a Protein Coding gene. Among its related pathways are Inositol phosphate metabolism (KEGG) and Metabolism. GO annotations related to this gene include phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity and phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity. An important paralog of this gene is INPP4B.

UniProtKB/Swiss-Prot for INPP4A Gene

  • Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-bisphosphate.

Gene Wiki entry for INPP4A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INPP4A Gene

Genomics for INPP4A Gene

Regulatory Elements for INPP4A Gene

Enhancers for INPP4A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around INPP4A on UCSC Golden Path with GeneCards custom track

Promoters for INPP4A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around INPP4A on UCSC Golden Path with GeneCards custom track

Genomic Location for INPP4A Gene

98,444,854 bp from pter
98,594,390 bp from pter
149,537 bases
Plus strand

Genomic View for INPP4A Gene

Genes around INPP4A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INPP4A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INPP4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INPP4A Gene

Proteins for INPP4A Gene

  • Protein details for INPP4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Type I inositol 3,4-bisphosphate 4-phosphatase
    Protein Accession:
    Secondary Accessions:
    • O15326
    • Q13187
    • Q53TD8
    • Q8TC02

    Protein attributes for INPP4A Gene

    977 amino acids
    Molecular mass:
    109956 Da
    Quaternary structure:
    • Interacts with INPP5F.

    Alternative splice isoforms for INPP4A Gene


neXtProt entry for INPP4A Gene

Proteomics data for INPP4A Gene at MOPED

Selected DME Specific Peptides for INPP4A Gene

Post-translational modifications for INPP4A Gene

  • Ubiquitination at Lys 959
  • Modification sites at PhosphoSitePlus

Domains & Families for INPP4A Gene

Gene Families for INPP4A Gene

Protein Domains for INPP4A Gene


Suggested Antigen Peptide Sequences for INPP4A Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C2 domain.
  • Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.
  • Contains 1 C2 domain.
  • Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.
genes like me logo Genes that share domains with INPP4A: view

Function for INPP4A Gene

Molecular function for INPP4A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
1-phosphatidyl-myo-inositol 3,4-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate.
UniProtKB/Swiss-Prot Function:
Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-bisphosphate.

Enzyme Numbers (IUBMB) for INPP4A Gene

Gene Ontology (GO) - Molecular Function for INPP4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25869668
genes like me logo Genes that share ontologies with INPP4A: view
genes like me logo Genes that share phenotypes with INPP4A: view

Animal Models for INPP4A Gene

MGI Knock Outs for INPP4A:

Animal Model Products

  • Taconic Biosciences Mouse Models for INPP4A

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for INPP4A Gene

Localization for INPP4A Gene

Subcellular locations from

Jensen Localization Image for INPP4A Gene COMPARTMENTS Subcellular localization image for INPP4A gene
Compartment Confidence
cytosol 5
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for INPP4A Gene

Pathways & Interactions for INPP4A Gene

genes like me logo Genes that share pathways with INPP4A: view

UniProtKB/Swiss-Prot Q96PE3-INP4A_HUMAN

  • Pathway: Signal transduction; phosphatidylinositol signaling pathway.

Gene Ontology (GO) - Biological Process for INPP4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process TAS --
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IEA,TAS --
GO:0043647 inositol phosphate metabolic process TAS --
genes like me logo Genes that share ontologies with INPP4A: view

No data available for SIGNOR curated interactions for INPP4A Gene

Drugs & Compounds for INPP4A Gene

(7) Additional Compounds for INPP4A Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1D-Myo-inositol 3,4-bisphosphate
  • 1D-Myo-inositol 3,4-bis(dihydrogen phosphate)
  • D-Myo-Inositol 3,4-bisphosphate
  • Inositol 3,4-bisphosphate
1D-myo-Inositol 3-phosphate
  • 1D-Myo-Inositol 3-monophosphate
  • 1L-Myo-Inositol 1-phosphate
  • D-Myo-Inositol 3-monophosphate
  • D-Myo-Inositol 3-phosphate
  • Inositol 3-monophosphate
1-Phosphatidyl-1D-myo-inositol 3-phosphate
  • 1-Phosphatidyl-1D-myo-inositol 3-phosphate
  • Phosphatidylinositol 3-phosphate
Myo-inositol 1-phosphate
  • 1-(Dihydrogen phosphate) DL-myo-Inositol
  • 1-(Dihydrogen phosphate) myo-Inositol
  • DL-myo-Inositol 1-phosphate
  • Myo-Inositol 1-monophosphate
  • Myo-Inositol 1-phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
genes like me logo Genes that share compounds with INPP4A: view

Transcripts for INPP4A Gene

Unigene Clusters for INPP4A Gene

Inositol polyphosphate-4-phosphatase, type I, 107kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for INPP4A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - - -

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28
SP1: - -

Relevant External Links for INPP4A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for INPP4A Gene

mRNA expression in normal human tissues for INPP4A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for INPP4A Gene

This gene is overexpressed in CD8 Tcells (10.1), Brain (9.1), Lymph node (7.4), and Frontal cortex (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for INPP4A Gene

SOURCE GeneReport for Unigene cluster for INPP4A Gene Hs.469386

mRNA Expression by UniProt/SwissProt for INPP4A Gene

Tissue specificity: Isoform 1 is expressed in the platelets, MEG-01 megakaryocytes and Jurkat T-cells. Isoform 2 is expressed in the brain.
genes like me logo Genes that share expression patterns with INPP4A: view

Protein tissue co-expression partners for INPP4A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for INPP4A Gene

Orthologs for INPP4A Gene

This gene was present in the common ancestor of animals.

Orthologs for INPP4A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia INPP4A 35
  • 90.56 (n)
  • 95.76 (a)
  • 96 (a)
(Canis familiaris)
Mammalia INPP4A 35
  • 92.73 (n)
  • 97.85 (a)
  • 98 (a)
(Mus musculus)
Mammalia Inpp4a 35
  • 89.98 (n)
  • 96.8 (a)
Inpp4a 16
Inpp4a 36
  • 97 (a)
(Pan troglodytes)
Mammalia INPP4A 35
  • 99.69 (n)
  • 99.9 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Inpp4a 35
  • 89.45 (n)
  • 96.7 (a)
(Monodelphis domestica)
Mammalia INPP4A 36
  • 91 (a)
(Gallus gallus)
Aves INPP4A 35
  • 79.9 (n)
  • 92.32 (a)
  • 94 (a)
(Anolis carolinensis)
Reptilia INPP4A 36
  • 89 (a)
(Danio rerio)
Actinopterygii Dr.12539 35
inpp4aa 35
  • 71.77 (n)
  • 77.94 (a)
inpp4aa 36
  • 77 (a)
inpp4ab 36
  • 82 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1846 37
  • 36 (a)
CG42271 35
  • 47.07 (n)
  • 35.47 (a)
CG42271 36
  • 21 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000124 35
  • 47.13 (n)
  • 34.9 (a)
(Caenorhabditis elegans)
Secernentea R01H10.7 36
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
Species with no ortholog for INPP4A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for INPP4A Gene

Gene Tree for INPP4A (if available)
Gene Tree for INPP4A (if available)

Paralogs for INPP4A Gene

Paralogs for INPP4A Gene

(1) SIMAP similar genes for INPP4A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with INPP4A: view

Variants for INPP4A Gene

Sequence variations from dbSNP and Humsavar for INPP4A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs2278206 - 98,555,781(-) TGCAG(A/C/T)GGAGG intron-variant, nc-transcript-variant, reference, missense
rs958314 -- 98,562,254(+) TCCAA(A/C)TTTTG intron-variant
rs961242 -- 98,522,516(-) ACCCA(C/T)TTTCT intron-variant
rs2871214 -- 98,497,914(+) ggaat(A/G)gctgt intron-variant
rs2871231 -- 98,530,349(+) GATTA(A/G)ACACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for INPP4A Gene

Variant ID Type Subtype PubMed ID
nsv518056 CNV Gain 19592680
nsv2840 CNV Loss 18451855

Variation tolerance for INPP4A Gene

Residual Variation Intolerance Score: 5.85% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.03; 50.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for INPP4A Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INPP4A Gene

Disorders for INPP4A Gene

Relevant External Links for INPP4A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for INPP4A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for INPP4A Gene

Publications for INPP4A Gene

  1. The cDNA cloning and characterization of inositol polyphosphate 4- phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family. (PMID: 9295334) Norris F.A. … Majerus P.W. (J. Biol. Chem. 1997) 2 3 4 23 67
  2. A genetic variation in inositol polyphosphate 4 phosphatase a enhances susceptibility to asthma. (PMID: 18187694) Sharma M. … Ghosh B. (Am. J. Respir. Crit. Care Med. 2008) 3 23
  3. Identification of a novel spliceoform of inositol polyphosphate 4- phosphatase type Ialpha expressed in human platelets: structure of human inositol polyphosphate 4-phosphatase type I gene. (PMID: 11485317) Shearn C.T. … Norris F.A. (Biochem. Biophys. Res. Commun. 2001) 3 23
  4. Assignment of the inositol polyphosphate 4-phosphatase type I gene (INPP4A) to human chromosome band 2q11.2 by in situ hybridization. (PMID: 10702694) Joseph R.E. … Norris F.A. (Cytogenet. Cell Genet. 1999) 3 23
  5. The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase. (PMID: 7608176) Norris F.A. … Majerus P.W. (J. Biol. Chem. 1995) 2 3

Products for INPP4A Gene

Sources for INPP4A Gene