Free for academic non-profit institutions. Other users need a Commercial license

Aliases for INPP4A Gene

Aliases for INPP4A Gene

  • Inositol Polyphosphate-4-Phosphatase, Type I, 107kDa 2 3
  • Inositol Polyphosphate-4-Phosphatase, Type I, 107kD 2 3
  • EC 3.1.3.66 4 63
  • INPP4 3 6
  • Type I Inositol 3,4-Bisphosphate 4-Phosphatase 3
  • Type I Inositol-3,4-Bisphosphate 4-Phosphatase 3
  • Inositol Polyphosphate 4-Phosphatase Type I 4
  • TVAS1 3

External Ids for INPP4A Gene

Previous Symbols for INPP4A Gene

  • INPP4

Summaries for INPP4A Gene

Entrez Gene Summary for INPP4A Gene

  • This gene encodes an Mg++ independent enzyme that hydrolyzes the 4-position phosphate from the inositol ring of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate, and inositol 3,4-bisphosphate. Multiple transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Aug 2008]

GeneCards Summary for INPP4A Gene

INPP4A (Inositol Polyphosphate-4-Phosphatase, Type I, 107kDa) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity and phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity. An important paralog of this gene is INPP4B.

UniProtKB/Swiss-Prot for INPP4A Gene

  • Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-bisphosphate

Gene Wiki entry for INPP4A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INPP4A Gene

Genomics for INPP4A Gene

Genomic Location for INPP4A Gene

Start:
98,444,854 bp from pter
End:
98,594,390 bp from pter
Size:
149,537 bases
Orientation:
Plus strand

Genomic View for INPP4A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for INPP4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INPP4A Gene

Regulatory Elements for INPP4A Gene

Proteins for INPP4A Gene

  • Protein details for INPP4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PE3-INP4A_HUMAN
    Recommended name:
    Type I inositol 3,4-bisphosphate 4-phosphatase
    Protein Accession:
    Q96PE3
    Secondary Accessions:
    • O15326
    • Q13187
    • Q53TD8
    • Q8TC02

    Protein attributes for INPP4A Gene

    Size:
    977 amino acids
    Molecular mass:
    109956 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for INPP4A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for INPP4A Gene

Proteomics data for INPP4A Gene at MOPED

Selected DME Specific Peptides for INPP4A Gene

Post-translational modifications for INPP4A Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys959

Other Protein References for INPP4A Gene

Domains for INPP4A Gene

Gene Families for INPP4A Gene

Protein Domains for INPP4A Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for INPP4A Gene

Graphical View of Domain Structure for InterPro Entry

Q96PE3

UniProtKB/Swiss-Prot:

INP4A_HUMAN
Domain:
  • Contains 1 C2 domain.:
    • Q96PE3
Family:
  • Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.:
    • Q96PE3
genes like me logo Genes that share domains with INPP4A: view

Function for INPP4A Gene

Molecular function for INPP4A Gene

UniProtKB/Swiss-Prot CatalyticActivity: 1-phosphatidyl-myo-inositol 3,4-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate
UniProtKB/Swiss-Prot Function: Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-bisphosphate

Enzyme Numbers (IUBMB) for INPP4A Gene

Gene Ontology (GO) - Molecular Function for INPP4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity IEA --
GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity IEA --
genes like me logo Genes that share ontologies with INPP4A: view
genes like me logo Genes that share phenotypes with INPP4A: view

miRNA for INPP4A Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for INPP4A Gene

Localization for INPP4A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for INPP4A Gene COMPARTMENTS Subcellular localization image for INPP4A gene
Compartment Confidence
cytosol 4
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for INPP4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with INPP4A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for INPP4A Gene

Pathways for INPP4A Gene

genes like me logo Genes that share pathways with INPP4A: view

UniProtKB/Swiss-Prot Q96PE3-INP4A_HUMAN

  • Pathway: Signal transduction; phosphatidylinositol signaling pathway

Interacting Proteins for INPP4A Gene

Gene Ontology (GO) - Biological Process for INPP4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process TAS --
GO:0006661 phosphatidylinositol biosynthetic process TAS --
GO:0007165 signal transduction TAS 7608176
GO:0016311 dephosphorylation IEA --
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IEA --
genes like me logo Genes that share ontologies with INPP4A: view

Compounds for INPP4A Gene

(5) HMDB Compounds for INPP4A Gene

Compound Synonyms Cas Number PubMed IDs
1D-Myo-inositol 3,4-bisphosphate
  • 1D-myo-inositol 3,4-bis(dihydrogen phosphate)
103597-56-4
1D-myo-Inositol 3-phosphate
  • D-myo-Inositol 3-phosphate
2831-74-5
1-Phosphatidyl-1D-myo-inositol 3-phosphate
  • 1-Phosphatidyl-1D-myo-inositol 3-phosphate
Not Available
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5
genes like me logo Genes that share compounds with INPP4A: view

Transcripts for INPP4A Gene

Unigene Clusters for INPP4A Gene

Inositol polyphosphate-4-phosphatase, type I, 107kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for INPP4A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - - -
SP2:
SP3:
SP4:

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28
SP1: - -
SP2:
SP3:
SP4:

Relevant External Links for INPP4A Gene

GeneLoc Exon Structure for
INPP4A
ECgene alternative splicing isoforms for
INPP4A

Expression for INPP4A Gene

mRNA expression in normal human tissues for INPP4A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for INPP4A Gene

SOURCE GeneReport for Unigene cluster for INPP4A Gene Hs.469386

mRNA Expression by UniProt/SwissProt for INPP4A Gene

Q96PE3-INP4A_HUMAN
Tissue specificity: Isoform 1 is expressed in the platelets, MEG-01 megakaryocytes and Jurkat T-cells. Isoform 2 is expressed in the brain.
genes like me logo Genes that share expressions with INPP4A: view

No data available for mRNA differential expression in normal tissues for INPP4A Gene

Orthologs for INPP4A Gene

This gene was present in the common ancestor of animals.

Orthologs for INPP4A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INPP4A 35
  • 99.69 (n)
  • 99.9 (a)
INPP4A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia INPP4A 35
  • 90.56 (n)
  • 95.76 (a)
INPP4A 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia INPP4A 35
  • 92.73 (n)
  • 97.85 (a)
INPP4A 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Inpp4a 35
  • 89.98 (n)
  • 96.8 (a)
Inpp4a 16
Inpp4a 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia INPP4A 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Inpp4a 35
  • 89.45 (n)
  • 96.7 (a)
chicken
(Gallus gallus)
Aves INPP4A 35
  • 79.9 (n)
  • 92.32 (a)
INPP4A 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia INPP4A 36
  • 89 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii Dr.12539 35
inpp4aa 35
  • 71.77 (n)
  • 77.94 (a)
inpp4aa 36
  • 77 (a)
OneToMany
inpp4ab 36
  • 82 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000124 35
  • 47.13 (n)
  • 34.9 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG42271 35
  • 47.07 (n)
  • 35.47 (a)
CG42271 36
  • 21 (a)
OneToMany
CG1846 37
  • 36 (a)
worm
(Caenorhabditis elegans)
Secernentea R01H10.7 36
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
OneToMany
Species with no ortholog for INPP4A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for INPP4A Gene

ENSEMBL:
Gene Tree for INPP4A (if available)
TreeFam:
Gene Tree for INPP4A (if available)

Paralogs for INPP4A Gene

Paralogs for INPP4A Gene

Selected SIMAP similar genes for INPP4A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with INPP4A: view

Variants for INPP4A Gene

Sequence variations from dbSNP and Humsavar for INPP4A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs222 -- 98,531,409(-) CACTA(C/T)GCTGT intron-variant
rs9662 -- 98,589,964(-) AGGGA(A/C/T)AAAAC utr-variant-3-prime, intron-variant
rs958314 -- 98,562,254(+) TCCAA(A/C)TTTTG intron-variant
rs961242 -- 98,522,516(-) ACCCA(C/T)TTTCT intron-variant
rs1001856 -- 98,568,960(+) CACCT(C/G)CTGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for INPP4A Gene

Variant ID Type Subtype PubMed ID
nsv518056 CNV Gain 19592680
nsv2840 CNV Loss 18451855

Relevant External Links for INPP4A Gene

HapMap Linkage Disequilibrium report
INPP4A
Human Gene Mutation Database (HGMD)
INPP4A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INPP4A Gene

Disorders for INPP4A Gene

Relevant External Links for INPP4A

Genetic Association Database (GAD)
INPP4A
Human Genome Epidemiology (HuGE) Navigator
INPP4A
genes like me logo Genes that share disorders with INPP4A: view

No data available for UniProtKB/Swiss-Prot for INPP4A Gene

Publications for INPP4A Gene

  1. The cDNA cloning and characterization of inositol polyphosphate 4- phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family. (PMID: 9295334) Norris F.A. … Majerus P.W. (J. Biol. Chem. 1997) 2 3 4 23
  2. Identification of a novel spliceoform of inositol polyphosphate 4- phosphatase type Ialpha expressed in human platelets: structure of human inositol polyphosphate 4-phosphatase type I gene. (PMID: 11485317) Shearn C.T. … Norris F.A. (Biochem. Biophys. Res. Commun. 2001) 3 4 23
  3. A genetic variation in inositol polyphosphate 4 phosphatase a enhances susceptibility to asthma. (PMID: 18187694) Sharma M. … Ghosh B. (Am. J. Respir. Crit. Care Med. 2008) 3 23 48
  4. The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase. (PMID: 7608176) Norris F.A. … Majerus P.W. (J. Biol. Chem. 1995) 2 3 4
  5. Assignment of the inositol polyphosphate 4-phosphatase type I gene (INPP4A) to human chromosome band 2q11.2 by in situ hybridization. (PMID: 10702694) Joseph R.E. … Norris F.A. (Cytogenet. Cell Genet. 1999) 3 23

Products for INPP4A Gene

  • antibodies-online peptides for INPP4A
  • antibodies-online antibodies for INPP4A
  • antibodies-online kits for INPP4A

Sources for INPP4A Gene

Back to Top

Content