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INPP4A Gene

protein-coding   GIFtS: 64
GCID: GC02P099061

Inositol Polyphosphate-4-Phosphatase, Type I, 107kDa

(Previous names: inositol polyphosphate-4-phosphatase, type I, 107kD)
(Previous symbol: INPP4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Inositol Polyphosphate-4-Phosphatase, Type I, 107kDa1 2     TVAS12
INPP41 2 5     Type I Inositol 3,4-Bisphosphate 4-Phosphatase2
EC 3.1.3.663 8     Type I Inositol-3,4-Bisphosphate 4-Phosphatase2
Inositol Polyphosphate-4-Phosphatase, Type I, 107kD1     Inositol Polyphosphate 4-Phosphatase Type I3

External Ids:    HGNC: 60741   Entrez Gene: 36312   Ensembl: ENSG000000409337   OMIM: 6009165   UniProtKB: Q96PE33   

Export aliases for INPP4A gene to outside databases

Previous GC identifers: GC02P097017 GC02P097513 GC02P098665 GC02P098682 GC02P098465 GC02P092826


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for INPP4A Gene:
This gene encodes an Mg++ independent enzyme that hydrolyzes the 4-position phosphate from the inositol ring of
phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate, and inositol 3,4-bisphosphate. Multiple
transcript variants encoding distinct isoforms have been described. (provided by RefSeq, Aug 2008)

GeneCards Summary for INPP4A Gene:
INPP4A (inositol polyphosphate-4-phosphatase, type I, 107kDa) is a protein-coding gene. Diseases associated with INPP4A include rabies, and vasculitis. GO annotations related to this gene include phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity and phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity. An important paralog of this gene is INPP4B.

UniProtKB/Swiss-Prot: INP4A_HUMAN, Q96PE3
Function: Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol
1,3,4-trisphosphate and inositol 3,4-bisphosphate

Gene Wiki entry for INPP4A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the INPP4A gene promoter:
         Sp1   Brachyury   Pax-6   POU3F1   Gfi-1   C/EBPalpha   HNF-1A   HNF-1   HSF2   Cart-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for INPP4A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat INPP4A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.2   Ensembl cytogenetic band:  2q11.2   HGNC cytogenetic band: 2q11.2

INPP4A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INPP4A gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P099061:  view genomic region     (about GC identifiers)

Start:
99,061,317 bp from pter      End:
99,210,853 bp from pter
Size:
149,537 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: INP4A_HUMAN, Q96PE3 (See protein sequence)
Recommended Name: Type I inositol 3,4-bisphosphate 4-phosphatase  
Size: 977 amino acids; 109956 Da
Secondary accessions: O15326 Q13187 Q53TD8 Q8TC02
Alternative splicing: 4 isoforms:  Q96PE3-1   Q96PE3-2   Q96PE3-3   Q96PE3-4   (Inactive)

Explore the universe of human proteins at neXtProt for INPP4A: NX_Q96PE3

Explore proteomics data for INPP4A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys959
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for INPP4A (Q96PE3) (see all 5)
     CGFIIKL  CKSAKDRT  MSVTLEQC  YRPPEGTYGK 


    See INPP4A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001127696.1  NP_001127697.1  NP_001557.1  NP_004018.1  

    ENSEMBL proteins: 
     ENSP00000386704   ENSP00000386777   ENSP00000386329   ENSP00000387294   ENSP00000427722  
     ENSP00000074304   ENSP00000442149  
    Reactome Protein details: Q96PE3

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: INPP4A
    Inositol polyphosphate phosphatases

    1 InterPro protein domain:
     IPR000008 C2_dom

    Graphical View of Domain Structure for InterPro Entry Q96PE3

    ProtoNet protein and cluster: Q96PE3

    1 Blocks protein domain: IPB000008 C2 domain

    UniProtKB/Swiss-Prot: INP4A_HUMAN, Q96PE3
    Similarity: Belongs to the inositol 3,4-bisphosphate 4-phosphatase family
    Similarity: Contains 1 C2 domain


    INPP4A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: INP4A_HUMAN, Q96PE3
    Function: Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol
    1,3,4-trisphosphate and inositol 3,4-bisphosphate
    Catalytic activity: 1-phosphatidyl-myo-inositol 3,4-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol
    3-phosphate + phosphate

         Enzyme Number (IUBMB): EC 3.1.3.661 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0016316phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity IEA--
    GO:0034597phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity IEA--
         
    INPP4A for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Inpp4a):
     behavior/neurological  growth/size/body  mortality/aging  muscle  nervous system 

    INPP4A for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for INPP4A
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    miRNA
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    miRTarBase miRNAs that target INPP4A:
    hsa-mir-1301-3p (MIRT036040), hsa-mir-877-5p (MIRT037226), hsa-mir-421 (MIRT039407), hsa-mir-23b-3p (MIRT046283)

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    Selected qRT-PCR Assays for microRNAs that regulate INPP4A (see all 14):
    hsa-miR-100* hsa-miR-16-2* hsa-miR-429 hsa-miR-7-2* hsa-miR-3120-3p hsa-miR-223 hsa-miR-200c hsa-miR-145*
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INPP4A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    INPP4A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for INPP4A About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38
    2PI Metabolism
    PI Metabolism0.65
    Synthesis of PIPs at the early endosome membrane0.00
    Synthesis of PIPs at the plasma membrane0.65
    3Inositol phosphate metabolism (KEGG)
    Inositol phosphate metabolism0.61
    Phosphatidylinositol signaling system0.61
    4Inositol phosphate metabolism (REACTOME)
    Inositol phosphate metabolism0.59
    Synthesis of IP2, IP, and Ins in the cytosol0.00
    5Glycerophospholipid biosynthesis
    Phospholipid metabolism0.64

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for INPP4A
        Insulin Signaling
    3-phosphoinositide degradation

    3 Reactome Pathways for INPP4A
        Synthesis of IP2, IP, and Ins in the cytosol
    Synthesis of PIPs at the plasma membrane
    Synthesis of PIPs at the early endosome membrane


    3 Kegg Pathways  (Kegg details for INPP4A):
        Inositol phosphate metabolism
    Metabolic pathways
    Phosphatidylinositol signaling system

    UniProtKB/Swiss-Prot: INP4A_HUMAN, Q96PE3
    Pathway: Signal transduction; phosphatidylinositol signaling pathway


    INPP4A for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for INPP4A
    Interactions:

        Search GeneGlobe Interaction Network for INPP4A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for INPP4A (Q96PE32, 3 ENSP000000743044) via UniProtKB, MINT, STRING, and/or I2D (see all 39)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD1Q157972, 3MINT-62011 I2D: score=3 
    CAPN1P073843, ENSP000002792474I2D: score=2 STRING: ENSP00000279247
    PIK3R1P279863, ENSP000002743354I2D: score=2 STRING: ENSP00000274335
    YWHABP319463I2D: score=1 
    FIG4ENSP000002301244STRING: ENSP00000230124
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006644phospholipid metabolic process TAS--
    GO:0006661phosphatidylinositol biosynthetic process TAS--
    GO:0007165signal transduction TAS7608176
    GO:0043647inositol phosphate metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    INPP4A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for INPP4A (INP4A)

    5 HMDB Compounds for INPP4A    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Phosphatidyl-1D-myo-inositol 3-phosphate1-Phosphatidyl-1D-myo-inositol 3-phosphate (see all 3)----
    1D-Myo-inositol 3,4-bisphosphate1D-myo-inositol 3,4-bis(dihydrogen phosphate) (see all 3)103597-56-4--
    1D-myo-Inositol 3-phosphateD-myo-Inositol 3-phosphate (see all 9)2831-74-5--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for INPP4A gene (4 alternative transcripts): 
    NM_001134224.1  NM_001134225.1  NM_001566.2  NM_004027.2  

    Unigene Cluster for INPP4A:

    Inositol polyphosphate-4-phosphatase, type I, 107kDa
    Hs.469386  [show with all ESTs]
    Unigene Representative Sequence: NM_001134224
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409016 ENST00000409851 ENST00000409463 ENST00000409540(uc010yvj.1)
    ENST00000463367 ENST00000523221 ENST00000468638 ENST00000467042 ENST00000498026
    ENST00000074304(uc002syy.3 uc010yvk.2 uc002syx.3) ENST00000545415(uc010fik.3)

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    Selected qRT-PCR Assays for microRNAs that regulate INPP4A (see all 14):
    hsa-miR-100* hsa-miR-16-2* hsa-miR-429 hsa-miR-7-2* hsa-miR-3120-3p hsa-miR-223 hsa-miR-200c hsa-miR-145*
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    Additional mRNA sequence: 

    AB462500.1 AF368319.1 AK091533.1 AK307823.1 BC005082.1 BC028361.2 U26398.1 U96919.1 

    7 DOTS entries:

    DT.97816574  DT.100024000  DT.443425  DT.95261450  DT.91878121  DT.40270709  DT.91977316 

    Selected AceView cDNA sequences (see all 147):

    AI052196 AI419691 AA626273 AA457029 BC028361 AA456873 CA424109 CA390888 
    BC005082 AA258664 BF115183 BQ215142 BG149268 AA976931 BF724199 CK819811 
    BF223797 AI193600 AK091533 AA700042 AF368319 AW518272 BM666704 AA235427 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for INPP4A    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
    SP1:              -                 -                                                                                   -                                       
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            

    ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28
    SP1:  -     -                     
    SP2:                              
    SP3:                              
    SP4:                              


    ECgene alternative splicing isoforms for INPP4A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    INPP4A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    INPP4A Expression
    About this image


    INPP4A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Kidney (Urinary System)
             Metanephros
     
     Testis (Reproductive System)
    INPP4A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    INPP4A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.469386

    UniProtKB/Swiss-Prot: INP4A_HUMAN, Q96PE3
    Tissue specificity: Isoform 1 is expressed in the platelets, MEG-01 megakaryocytes and Jurkat T-cells. Isoform 2
    is expressed in the brain

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INPP4A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for INPP4A gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Inpp4a1 , 5 inositol polyphosphate-4-phosphatase, type I1, 5 89.98(n)1
    96.8(a)1
      1 (15.46 cM)5
    2691801  NM_030266.31  NP_084542.21 
     372998655 
    chicken
    (Gallus gallus)
    Aves INPP4A1 inositol polyphosphate-4-phosphatase, type I, 107kDa 79.9(n)
    92.32(a)
      418690  XM_004938484.1  XP_004938541.1 
    lizard
    (Anolis carolinensis)
    Reptilia INPP4A6
    inositol polyphosphate-4-phosphatase, type I, 107k...
    89(a)
    1 ↔ 1
    3(109222961-109296977)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL865080.22   -- 82.35(n)    AL865080.2 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.125392 Transcribed sequence with weak similarity to protein more 75.79(n)    BI533664.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG18463
    CG422711
    inositol-1,3,4-trisphosphate
    4-phosphatase3
    CG422711
    36(a)3
    47.07(n)1
    35.47(a)1
      12E53
    27688921  NM_206711.21  NP_996434.21 
    worm
    (Caenorhabditis elegans)
    Secernentea R01H10.76
    Protein R01H10.7 (R01H10.7) mRNA, complete cds
    22(a)
    1 → many
    III(10261758-10267381) WBGene00010975


    ENSEMBL Gene Tree for INPP4A (if available)
    TreeFam Gene Tree for INPP4A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for INPP4A gene
    INPP4B2  
    1 SIMAP similar gene for INPP4A using alignment to 4 protein entries:     INP4A_HUMAN (see all proteins):
    INPP4B

    INPP4A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for INPP4A (see all 2734)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs776927081,2
    C,F--98716570(+) GAAAAT/CGTGAT 4 -- us2k13Minor allele frequency- C:0.06CSA WA 122
    rs1916066771,2
    C--98716717(+) ATTTAA/TTTTTT 4 -- us2k10--------
    rs1473316951,2
    C--98716722(+) ATTTTG/TTTTTC 4 -- us2k10--------
    rs791325611,2
    C--98716876(+) CATGGA/CGAAAC 4 -- us2k10--------
    rs563331121,2
    C--98716964(+) CAGGAA/GAATTG 4 -- us2k10--------
    rs1837146611,2
    --98716993(+) AGGTTA/GCGGTG 4 -- us2k10--------
    rs1432020221,2
    C--98717008(+) GAGATC/TGCGCC 4 -- us2k10--------
    rs560470021,2
    --98717009(+) AGATCA/GCGCCA 4 -- us2k10--------
    rs1394915791,2
    C--98717042(+) AGAGCA/GAAACT 4 -- us2k10--------
    rs1880534021,2
    --98717049(+) AACTCC/TATCCC 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for INPP4A (99061317 - 99210853 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for INPP4A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2840CNV Loss18451855
    nsv518056CNV Gain19592680

    Human Gene Mutation Database (HGMD): INPP4A
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing INPP4A
    DNA2.0 Custom Variant and Variant Library Synthesis for INPP4A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600916    OMIM disorders: --

    6 diseases for INPP4A:    
    About MalaCards
    rabies    vasculitis    asthma    bipolar disorder
    malaria    neuronitis


    INPP4A for disorders           About GeneDecksing

    Genetic Association Database (GAD): INPP4A
    Human Genome Epidemiology (HuGE) Navigator: INPP4A (2 documents)

    Export disorders for INPP4A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for INPP4A gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with INPP4A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The cDNA cloning and characterization of inositol polyphosphate 4- phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family. (PubMed id 9295334)1, 2, 3, 9 Norris F.A.... Majerus P.W. (J. Biol. Chem. 1997)
    2. The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase. (PubMed id 7608176)1, 2, 3 Norris F.A.... Majerus P.W. (J. Biol. Chem. 1995)
    3. Identification of a novel spliceoform of inositol polyphosphate 4- phosphatase type Ialpha expressed in human platelets: structure of human inositol polyphosphate 4-phosphatase type I gene. (PubMed id 11485317)1, 2, 9 Shearn C.T.... Norris F.A. (Biochem. Biophys. Res. Commun. 2001)
    4. A genetic variation in inositol polyphosphate 4 phosphatase a enhances susceptibility to asthma. (PubMed id 18187694)1, 4, 9 Sharma M....Ghosh B. (Am. J. Respir. Crit. Care Med. 2008)
    5. Assessing the reproducibility of asthma candidate gene associations, using genome-wide data. (PubMed id 19264973)1, 4 Rogers A.J....Weiss S.T. (Am. J. Respir. Crit. Care Med. 2009)
    6. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Assignment of the inositol polyphosphate 4-phosphatase type I gene (INPP4A) to human chromosome band 2q11.2 by in situ hybridization. (PubMed id 10702694)1, 9 Joseph R.E....Norris F.A. (Cytogenet. Cell Genet. 1999)
    9. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....YA!A+ez-MA^ M. (J. Biol. Chem. 2013)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3631 HGNC: 6074 AceView: INPP4A Ensembl:ENSG00000040933 euGenes: HUgn3631
    ECgene: INPP4A Kegg: 3631 H-InvDB: INPP4A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for INPP4A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for INPP4A gene:
    Search GeneIP for patents involving INPP4A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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