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Aliases for INPP1 Gene

Aliases for INPP1 Gene

  • Inositol Polyphosphate-1-Phosphatase 2 3
  • IPPase 3 4
  • IPP 3 4
  • Inositol Polyphosphate 1-Phosphatase 3
  • EC 4

External Ids for INPP1 Gene

Previous GeneCards Identifiers for INPP1 Gene

  • GC02P189402
  • GC02P189911
  • GC02P191172
  • GC02P191410
  • GC02P191033
  • GC02P190916
  • GC02P183068

Summaries for INPP1 Gene

Entrez Gene Summary for INPP1 Gene

  • This gene encodes the enzyme inositol polyphosphate-1-phosphatase, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 1 of the inositol ring from the polyphosphates inositol 1,4-bisphosphate and inositol 1,3,4-trisphophosphate. [provided by RefSeq, Jul 2008]

GeneCards Summary for INPP1 Gene

INPP1 (Inositol Polyphosphate-1-Phosphatase) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include inositol-1,4-bisphosphate 1-phosphatase activity and inositol-1,3,4-trisphosphate 1-phosphatase activity.

Gene Wiki entry for INPP1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INPP1 Gene

Genomics for INPP1 Gene

Regulatory Elements for INPP1 Gene

Genomic Location for INPP1 Gene

190,343,470 bp from pter
190,371,665 bp from pter
28,196 bases
Plus strand

Genomic View for INPP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for INPP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INPP1 Gene

Proteins for INPP1 Gene

  • Protein details for INPP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inositol polyphosphate 1-phosphatase
    Protein Accession:
    Secondary Accessions:

    Protein attributes for INPP1 Gene

    399 amino acids
    Molecular mass:
    43998 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Monomer.

neXtProt entry for INPP1 Gene

Proteomics data for INPP1 Gene at MOPED

Post-translational modifications for INPP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for INPP1 Gene

Domains for INPP1 Gene

Gene Families for INPP1 Gene

Protein Domains for INPP1 Gene

Suggested Antigen Peptide Sequences for INPP1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the inositol monophosphatase family.
  • Belongs to the inositol monophosphatase family.
genes like me logo Genes that share domains with INPP1: view

Function for INPP1 Gene

Molecular function for INPP1 Gene

GENATLAS Biochemistry:
inositol 1,4,5-triphosphate 1-phosphatase,ubiquitously expressed,with highest levels in kidney and pancreas,inositol signaling pathway,controled by calcineurin
UniProtKB/Swiss-Prot CatalyticActivity:
1D-myo-inositol 1,4-bisphosphate + H(2)O = 1D-myo-inositol 4-phosphate + phosphate
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by Li(+)

Enzyme Numbers (IUBMB) for INPP1 Gene

Gene Ontology (GO) - Molecular Function for INPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004441 inositol-1,4-bisphosphate 1-phosphatase activity TAS --
GO:0046872 metal ion binding IEA --
GO:0052829 inositol-1,3,4-trisphosphate 1-phosphatase activity TAS --
genes like me logo Genes that share ontologies with INPP1: view

Phenotypes for INPP1 Gene

genes like me logo Genes that share phenotypes with INPP1: view

Animal Models for INPP1 Gene

MGI Knock Outs for INPP1:

Animal Model Products

miRNA for INPP1 Gene

miRTarBase miRNAs that target INPP1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for INPP1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for INPP1 Gene

Localization for INPP1 Gene

Subcellular locations from

Jensen Localization Image for INPP1 Gene COMPARTMENTS Subcellular localization image for INPP1 gene
Compartment Confidence
cytosol 4
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for INPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with INPP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for INPP1 Gene

Pathways for INPP1 Gene

genes like me logo Genes that share pathways with INPP1: view

UniProtKB/Swiss-Prot P49441-INPP_HUMAN

  • Pathway: Signal transduction; phosphatidylinositol signaling pathway

Gene Ontology (GO) - Biological Process for INPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006796 phosphate-containing compound metabolic process TAS 8390685
GO:0007165 signal transduction TAS 8390685
GO:0016311 dephosphorylation TAS 8390685
GO:0043647 inositol phosphate metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with INPP1: view

Drugs for INPP1 Gene

(9) HMDB Compounds for INPP1 Gene

Compound Synonyms Cas Number PubMed IDs
1D-Myo-inositol 1,4-bisphosphate
  • 1D-Myo-inositol 1,4-bisphosphate
1D-Myo-inositol 3,4-bisphosphate
  • 1D-Myo-inositol 3,4-bis(dihydrogen phosphate)
D-Myo-inositol 4-phosphate
  • 1D-Myo-inositol 4-monophosphate
Inositol 1,3,4-trisphosphate
  • 1,3,4-Itp
  • Li

(12) Novoseek inferred chemical compound relationships for INPP1 Gene

Compound -log(P) Hits PubMed IDs
inositol 1,4-bisphosphate 80.2 1
lithium 78.3 16
inositol 75.7 10
inositol monophosphate 65.7 2
abscisic acid 47 1
genes like me logo Genes that share compounds with INPP1: view

Transcripts for INPP1 Gene

Unigene Clusters for INPP1 Gene

Inositol polyphosphate-1-phosphatase:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for INPP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for INPP1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b
SP1: - - -
SP2: - - - -
SP4: - - - -
SP5: - - -
SP6: - - -
SP7: - -

Relevant External Links for INPP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for INPP1 Gene

mRNA expression in normal human tissues for INPP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for INPP1 Gene

This gene is overexpressed in Oral epithelium (7.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for INPP1 Gene

SOURCE GeneReport for Unigene cluster for INPP1 Gene Hs.32309

mRNA Expression by UniProt/SwissProt for INPP1 Gene

Tissue specificity: Ubiquitously expressed, with highest levels in pancreas and kidney
genes like me logo Genes that share expressions with INPP1: view

Expression partners for INPP1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for INPP1 Gene

Orthologs for INPP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for INPP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia INPP1 35
  • 84.29 (n)
  • 82.46 (a)
INPP1 36
  • 83 (a)
(Canis familiaris)
Mammalia INPP1 35
  • 76.19 (n)
  • 76.44 (a)
INPP1 36
  • 77 (a)
(Mus musculus)
Mammalia Inpp1 35
  • 81.01 (n)
  • 81.77 (a)
Inpp1 16
Inpp1 36
  • 81 (a)
(Pan troglodytes)
Mammalia INPP1 35
  • 99.58 (n)
  • 99.75 (a)
INPP1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Inpp1 35
  • 82.32 (n)
  • 81.06 (a)
(Monodelphis domestica)
Mammalia INPP1 36
  • 76 (a)
(Anolis carolinensis)
Reptilia INPP1 36
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia inpp1 35
  • 61.64 (n)
  • 60.1 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68618 35
(Danio rerio)
Actinopterygii LOC555899 35
  • 52.99 (n)
  • 48.79 (a)
CR318593.1 36
  • 46 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ipp 37
  • 38 (a)
Ipp 35
  • 49.08 (n)
  • 42.27 (a)
Ipp 36
  • 39 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001047 35
  • 49.44 (n)
  • 42.09 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
Species with no ortholog for INPP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for INPP1 Gene

Gene Tree for INPP1 (if available)
Gene Tree for INPP1 (if available)

Paralogs for INPP1 Gene Pseudogenes for INPP1 Gene

genes like me logo Genes that share paralogs with INPP1: view

No data available for Paralogs for INPP1 Gene

Variants for INPP1 Gene

Sequence variations from dbSNP and Humsavar for INPP1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1372054 -- 190,343,621(+) GGGCA(A/G)GCGTG utr-variant-5-prime, upstream-variant-2KB
rs1530225 -- 190,367,655(-) AGGAT(C/T)GCTTG intron-variant
rs2067389 -- 190,344,169(+) gggcc(C/T)ggccA intron-variant
rs2067397 -- 190,359,324(+) AAGGT(C/G)CTAGC intron-variant
rs2067399 -- 190,359,573(+) AAAAA(A/G)AAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for INPP1 Gene

Variant ID Type Subtype PubMed ID
dgv669e201 CNV Deletion 23290073
esv2721265 CNV Deletion 23290073
esv2005944 CNV Deletion 18987734
esv2721267 CNV Deletion 23290073
esv2131026 CNV Deletion 18987734
nsv215297 CNV Insertion 16902084

Relevant External Links for INPP1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INPP1 Gene

Disorders for INPP1 Gene

(1) University of Copenhagen DISEASES for INPP1 Gene

(1) Novoseek inferred disease relationships for INPP1 Gene

Disease -log(P) Hits PubMed IDs
bipolar disorder 67.9 3

Relevant External Links for INPP1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with INPP1: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot and Genatlas for INPP1 Gene

Publications for INPP1 Gene

  1. Cloning, heterologous expression, and chromosomal localization of human inositol polyphosphate 1-phosphatase. (PMID: 8390685) York J.D. … Majerus P.W. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 3 4 23
  2. The polymorphic inositol polyphosphate 1-phosphatase gene as a candidate for pharmacogenetic prediction of lithium-responsive manic- depressive illness. (PMID: 9682271) Steen V.M. … Gulbrandsen A.K. (Pharmacogenetics 1998) 3 4 23
  3. Genomic structure and sequence analysis of a human inositol polyphosphate 1-phosphatase gene (INPP1). (PMID: 10780272) Lovlie R. … Steen V.M. (Pharmacogenetics 1999) 3 4 23
  4. Manic-depressive illness: an association study with the inositol polyphosphate 1-phosphatase and serotonin transporter genes. (PMID: 11901356) Piccardi M.P. … Del Zompo M. (Psychiatr. Genet. 2002) 3 23 48
  5. Association study of the INPP1, 5HTT, BDNF, AP-2beta and GSK-3beta GENE variants and restrospectively scored response to lithium prophylaxis in bipolar disorder. (PMID: 16787706) Michelon L. … Vallada H. (Neurosci. Lett. 2006) 3 23 48

Products for INPP1 Gene

Sources for INPP1 Gene

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