Free for academic non-profit institutions. Other users need a Commercial license

Aliases for INPP1 Gene

Aliases for INPP1 Gene

  • Inositol Polyphosphate-1-Phosphatase 2 3
  • IPPase 3 4
  • IPP 3 4
  • EC 3.1.3.57 4

External Ids for INPP1 Gene

Previous GeneCards Identifiers for INPP1 Gene

  • GC02P189402
  • GC02P189911
  • GC02P191172
  • GC02P191410
  • GC02P191033
  • GC02P190916
  • GC02P183068

Summaries for INPP1 Gene

Entrez Gene Summary for INPP1 Gene

  • This gene encodes the enzyme inositol polyphosphate-1-phosphatase, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 1 of the inositol ring from the polyphosphates inositol 1,4-bisphosphate and inositol 1,3,4-trisphophosphate. [provided by RefSeq, Jul 2008]

GeneCards Summary for INPP1 Gene

INPP1 (Inositol Polyphosphate-1-Phosphatase) is a Protein Coding gene. Diseases associated with INPP1 include bipolar disorder. Among its related pathways are Metabolism and Inositol phosphate metabolism (KEGG). GO annotations related to this gene include inositol-1,4-bisphosphate 1-phosphatase activity and inositol-1,3,4-trisphosphate 1-phosphatase activity.

Gene Wiki entry for INPP1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INPP1 Gene

Genomics for INPP1 Gene

Regulatory Elements for INPP1 Gene

Genomic Location for INPP1 Gene

Chromosome:
2
Start:
190,343,470 bp from pter
End:
190,371,665 bp from pter
Size:
28,196 bases
Orientation:
Plus strand

Genomic View for INPP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for INPP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INPP1 Gene

Proteins for INPP1 Gene

  • Protein details for INPP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49441-INPP_HUMAN
    Recommended name:
    Inositol polyphosphate 1-phosphatase
    Protein Accession:
    P49441

    Protein attributes for INPP1 Gene

    Size:
    399 amino acids
    Molecular mass:
    43998 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Monomer.

neXtProt entry for INPP1 Gene

Proteomics data for INPP1 Gene at MOPED

Post-translational modifications for INPP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for INPP1 Gene

Domains & Families for INPP1 Gene

Gene Families for INPP1 Gene

Protein Domains for INPP1 Gene

Suggested Antigen Peptide Sequences for INPP1 Gene

Graphical View of Domain Structure for InterPro Entry

P49441

UniProtKB/Swiss-Prot:

INPP_HUMAN :
  • Belongs to the inositol monophosphatase family.
Family:
  • Belongs to the inositol monophosphatase family.
genes like me logo Genes that share domains with INPP1: view

Function for INPP1 Gene

Molecular function for INPP1 Gene

GENATLAS Biochemistry:
inositol 1,4,5-triphosphate 1-phosphatase,ubiquitously expressed,with highest levels in kidney and pancreas,inositol signaling pathway,controled by calcineurin
UniProtKB/Swiss-Prot CatalyticActivity:
1D-myo-inositol 1,4-bisphosphate + H(2)O = 1D-myo-inositol 4-phosphate + phosphate
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by Li(+)

Enzyme Numbers (IUBMB) for INPP1 Gene

Gene Ontology (GO) - Molecular Function for INPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IBA --
GO:0004441 inositol-1,4-bisphosphate 1-phosphatase activity TAS --
GO:0052829 inositol-1,3,4-trisphosphate 1-phosphatase activity TAS --
genes like me logo Genes that share ontologies with INPP1: view

Phenotypes for INPP1 Gene

genes like me logo Genes that share phenotypes with INPP1: view

Animal Models for INPP1 Gene

MGI Knock Outs for INPP1:

Animal Model Products

miRNA for INPP1 Gene

miRTarBase miRNAs that target INPP1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for INPP1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for INPP1 Gene

Localization for INPP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for INPP1 Gene COMPARTMENTS Subcellular localization image for INPP1 gene
Compartment Confidence
cytosol 4
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for INPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with INPP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for INPP1 Gene

Pathways & Interactions for INPP1 Gene

genes like me logo Genes that share pathways with INPP1: view

UniProtKB/Swiss-Prot P49441-INPP_HUMAN

  • Pathway: Signal transduction; phosphatidylinositol signaling pathway

Gene Ontology (GO) - Biological Process for INPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation --
GO:0006796 phosphate-containing compound metabolic process TAS 8390685
GO:0007165 signal transduction TAS 8390685
GO:0043647 inositol phosphate metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with INPP1: view

No data available for SIGNOR curated interactions for INPP1 Gene

Drugs & Compounds for INPP1 Gene

(6) Drugs for INPP1 Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Lithium Approved Pharma 206
D-Myo-Inositol-1,4-Bisphosphate Experimental Pharma 0
fructose Experimental Pharma 0
arachidonic acid Experimental Nutra Potentiation, Activator 27
Magnesium Nutra 0

(13) Additional Compounds for INPP1 Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1D-Myo-inositol 3,4-bisphosphate
  • 1D-Myo-inositol 3,4-bis(dihydrogen phosphate)
  • D-Myo-Inositol 3,4-bisphosphate
  • Inositol 3,4-bisphosphate
103597-56-4
D-Myo-inositol 4-phosphate
  • 1D-Myo-inositol 4-monophosphate
  • 1D-Myo-inositol 4-phosphate
  • D-Myo-inositol-4-phosphate
  • D-Myoinositol 4-phosphate
  • Inositol 4-phosphate
46495-39-0
Inositol 1,3,4-trisphosphate
  • 1,3,4-Itp
  • 1D-Myo-Inositol 1,3,4-trisphosphate
  • D-Myo-Inositol 1,3,4-trisphosphate
  • I3S
  • Inositol 1,3,4-triphosphate
98102-63-7
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
genes like me logo Genes that share compounds with INPP1: view

Transcripts for INPP1 Gene

Unigene Clusters for INPP1 Gene

Inositol polyphosphate-1-phosphatase:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for INPP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for INPP1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b
SP1: - - -
SP2: - - - -
SP3:
SP4: - - - -
SP5: - - -
SP6: - - -
SP7: - -

Relevant External Links for INPP1 Gene

GeneLoc Exon Structure for
INPP1
ECgene alternative splicing isoforms for
INPP1

Expression for INPP1 Gene

mRNA expression in normal human tissues for INPP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for INPP1 Gene

This gene is overexpressed in Oral epithelium (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for INPP1 Gene



SOURCE GeneReport for Unigene cluster for INPP1 Gene Hs.32309

mRNA Expression by UniProt/SwissProt for INPP1 Gene

P49441-INPP_HUMAN
Tissue specificity: Ubiquitously expressed, with highest levels in pancreas and kidney
genes like me logo Genes that share expression patterns with INPP1: view

Protein tissue co-expression partners for INPP1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for INPP1 Gene

Orthologs for INPP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for INPP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia INPP1 35
  • 84.29 (n)
  • 82.46 (a)
INPP1 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia INPP1 35
  • 76.19 (n)
  • 76.44 (a)
INPP1 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Inpp1 35
  • 81.01 (n)
  • 81.77 (a)
Inpp1 16
Inpp1 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia INPP1 35
  • 99.58 (n)
  • 99.75 (a)
INPP1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Inpp1 35
  • 82.32 (n)
  • 81.06 (a)
oppossum
(Monodelphis domestica)
Mammalia INPP1 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia INPP1 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia inpp1 35
  • 61.64 (n)
  • 60.1 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68618 35
zebrafish
(Danio rerio)
Actinopterygii LOC555899 35
  • 52.99 (n)
  • 48.79 (a)
CR318593.1 36
  • 46 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Ipp 37
  • 38 (a)
Ipp 35
  • 49.08 (n)
  • 42.27 (a)
Ipp 36
  • 39 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001047 35
  • 49.44 (n)
  • 42.09 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
OneToOne
Species with no ortholog for INPP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for INPP1 Gene

ENSEMBL:
Gene Tree for INPP1 (if available)
TreeFam:
Gene Tree for INPP1 (if available)

Paralogs for INPP1 Gene

Pseudogenes.org Pseudogenes for INPP1 Gene

genes like me logo Genes that share paralogs with INPP1: view

No data available for Paralogs for INPP1 Gene

Variants for INPP1 Gene

Sequence variations from dbSNP and Humsavar for INPP1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs4656 -- 190,360,255(+) AAGAC(A/G/T)CTGGC synonymous-codon, reference
rs4940 -- 190,366,775(+) ACAAG(A/G)GCATC frameshift-variant, reference
rs909270 -- 190,368,449(+) TACAG(A/G)AGGGG intron-variant
rs909272 -- 190,368,650(+) TAAAA(C/T)GTACA intron-variant
rs972689 -- 190,362,766(+) GAACT(A/G)AATGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for INPP1 Gene

Variant ID Type Subtype PubMed ID
dgv669e201 CNV Deletion 23290073
esv2721265 CNV Deletion 23290073
esv2005944 CNV Deletion 18987734
esv2721267 CNV Deletion 23290073
esv2131026 CNV Deletion 18987734
nsv215297 CNV Insertion 16902084

Variation tolerance for INPP1 Gene

Residual Variation Intolerance Score: 25.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.16; 61.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for INPP1 Gene

HapMap Linkage Disequilibrium report
INPP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INPP1 Gene

Disorders for INPP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for INPP1 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
bipolar disorder
  • major affective disorder 1
- elite association
Search INPP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for INPP1

Genetic Association Database (GAD)
INPP1
Human Genome Epidemiology (HuGE) Navigator
INPP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
INPP1
genes like me logo Genes that share disorders with INPP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for INPP1 Gene

Publications for INPP1 Gene

  1. Cloning, heterologous expression, and chromosomal localization of human inositol polyphosphate 1-phosphatase. (PMID: 8390685) York J.D. … Majerus P.W. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 23 67
  2. FIERY1 regulates light-mediated repression of cell elongation and flowering time via its 3'(2'),5'-bisphosphate nucleotidase activity. (PMID: 19077168) Kim B.H. … von Arnim A.G. (Plant J. 2009) 23 67
  3. Lithium pharmacodynamics and pharmacogenetics: focus on inositol mono phosphatase (IMPase), inositol poliphosphatase (IPPase) and glycogen sinthase kinase 3 beta (GSK-3 beta). (PMID: 19442155) Serretti A. … De Ronchi D. (Curr. Med. Chem. 2009) 23 67
  4. The pharmacogenetics of lithium response depends upon clinical co-morbidity. (PMID: 17570738) Bremer T. … Kelsoe J.R. (Mol Diagn Ther 2007) 23 67
  5. Identification of mitogen-activated protein kinase docking sites in enzymes that metabolize phosphatidylinositols and inositol phosphates. (PMID: 16445858) Caldwell K.K. … Buckley C.T. (Cell Commun. Signal 2006) 23 67

Products for INPP1 Gene

Sources for INPP1 Gene

Back to Top

Content