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Aliases for INO80E Gene

Aliases for INO80E Gene

  • INO80 Complex Subunit E 2 3 5
  • Coiled-Coil Domain-Containing Protein 95 3 4
  • Coiled-Coil Domain Containing 95 2 3
  • CCDC95 3 4

External Ids for INO80E Gene

Previous HGNC Symbols for INO80E Gene

  • CCDC95

Previous GeneCards Identifiers for INO80E Gene

  • GC16P029916
  • GC16P027668

Summaries for INO80E Gene

GeneCards Summary for INO80E Gene

INO80E (INO80 Complex Subunit E) is a Protein Coding gene. Among its related pathways are DNA Double-Strand Break Repair and Transcription-Coupled Nucleotide Excision Repair (TC-NER).

UniProtKB/Swiss-Prot for INO80E Gene

  • Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INO80E Gene

Genomics for INO80E Gene

Regulatory Elements for INO80E Gene

Promoters for INO80E Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around INO80E on UCSC Golden Path with GeneCards custom track

Genomic Location for INO80E Gene

Chromosome:
16
Start:
29,995,294 bp from pter
End:
30,005,793 bp from pter
Size:
10,500 bases
Orientation:
Plus strand

Genomic View for INO80E Gene

Genes around INO80E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INO80E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INO80E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INO80E Gene

Proteins for INO80E Gene

  • Protein details for INO80E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBZ0-IN80E_HUMAN
    Recommended name:
    INO80 complex subunit E
    Protein Accession:
    Q8NBZ0
    Secondary Accessions:
    • Q6Y2K3

    Protein attributes for INO80E Gene

    Size:
    244 amino acids
    Molecular mass:
    26478 Da
    Quaternary structure:
    • Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the N-terminus of INO80.

    Alternative splice isoforms for INO80E Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for INO80E Gene

Proteomics data for INO80E Gene at MOPED

Post-translational modifications for INO80E Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for INO80E Gene

Domains & Families for INO80E Gene

Gene Families for INO80E Gene

Protein Domains for INO80E Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for INO80E Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with INO80E: view

No data available for UniProtKB/Swiss-Prot for INO80E Gene

Function for INO80E Gene

Molecular function for INO80E Gene

UniProtKB/Swiss-Prot Function:
Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
genes like me logo Genes that share phenotypes with INO80E: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for INO80E Gene

Localization for INO80E Gene

Subcellular locations from UniProtKB/Swiss-Prot for INO80E Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for INO80E Gene COMPARTMENTS Subcellular localization image for INO80E gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for INO80E Gene

Pathways & Interactions for INO80E Gene

genes like me logo Genes that share pathways with INO80E: view

Gene Ontology (GO) - Biological Process for INO80E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IEA --
genes like me logo Genes that share ontologies with INO80E: view

No data available for SIGNOR curated interactions for INO80E Gene

Drugs & Compounds for INO80E Gene

No Compound Related Data Available

Transcripts for INO80E Gene

Unigene Clusters for INO80E Gene

INO80 complex subunit E:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for INO80E Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d
SP1:
SP2: - - - - -
SP3: - - - - - -
SP4:
SP5: - - - -
SP6: - - - - -
SP7: - - - - - - -

Relevant External Links for INO80E Gene

GeneLoc Exon Structure for
INO80E
ECgene alternative splicing isoforms for
INO80E

Expression for INO80E Gene

mRNA expression in normal human tissues for INO80E Gene

Protein differential expression in normal tissues from HIPED for INO80E Gene

This gene is overexpressed in Serum (44.6) and Peripheral blood mononuclear cells (10.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for INO80E Gene



SOURCE GeneReport for Unigene cluster for INO80E Gene Hs.434864

genes like me logo Genes that share expression patterns with INO80E: view

Protein tissue co-expression partners for INO80E Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for INO80E Gene

Orthologs for INO80E Gene

This gene was present in the common ancestor of animals.

Orthologs for INO80E Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia INO80E 35
  • 92.08 (n)
  • 96.72 (a)
INO80E 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia INO80E 35
  • 92.9 (n)
  • 96.72 (a)
INO80E 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ino80e 35
  • 87.11 (n)
  • 92.27 (a)
Ino80e 16
Ino80e 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia INO80E 35
  • 99.45 (n)
  • 99.18 (a)
INO80E 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ino80e 35
  • 88.25 (n)
  • 94.26 (a)
oppossum
(Monodelphis domestica)
Mammalia INO80E 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia INO80E 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia INO80E 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ino80e 35
  • 63.35 (n)
  • 63.2 (a)
zebrafish
(Danio rerio)
Actinopterygii ino80e 35
  • 55.95 (n)
  • 55.1 (a)
ino80e 36
  • 52 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG18004 36
  • 25 (a)
OneToOne
Species with no ortholog for INO80E:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for INO80E Gene

ENSEMBL:
Gene Tree for INO80E (if available)
TreeFam:
Gene Tree for INO80E (if available)

Paralogs for INO80E Gene

(2) SIMAP similar genes for INO80E Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with INO80E: view

No data available for Paralogs for INO80E Gene

Variants for INO80E Gene

Sequence variations from dbSNP and Humsavar for INO80E Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs4389160 -- 30,001,437(-) GGGAA(C/G/T)GGGGG intron-variant, nc-transcript-variant, reference, synonymous-codon
rs4787491 -- 30,004,016(+) AGGGT(A/G)AGTGA intron-variant, nc-transcript-variant, utr-variant-3-prime
rs4788207 -- 29,998,953(+) ggcag(A/G)agaat intron-variant
rs4788208 -- 29,999,059(-) aaaaa(A/C/G/T)CACAT intron-variant
rs4788209 -- 30,001,945(+) TGGCA(C/T)CTATA intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for INO80E Gene

Variant ID Type Subtype PubMed ID
nsv905717 CNV Loss 21882294
dgv2668n71 CNV Loss 21882294
esv997840 CNV Deletion 20482838

Variation tolerance for INO80E Gene

Residual Variation Intolerance Score: 80.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.21; 24.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for INO80E Gene

HapMap Linkage Disequilibrium report
INO80E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INO80E Gene

Disorders for INO80E Gene

Relevant External Links for INO80E

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
INO80E

No disorders were found for INO80E Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for INO80E Gene

Publications for INO80E Gene

  1. A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex. (PMID: 16230350) Jin J. … Conaway J.W. (J. Biol. Chem. 2005) 2 3 4 67
  2. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3

Products for INO80E Gene

Sources for INO80E Gene

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