INO80E Gene
protein-coding GIFtS: 45
GCID: GC16P030007
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INO80 complex subunit E(Previous name: coiled-coil domain containing 95 )
(Previous symbol: CCDC95)
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Aliases
for INO80E gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| INO80 Complex Subunit E1 2 | | CCDC951 2 3 | | Coiled-Coil Domain Containing 951 2 | | Coiled-Coil Domain-Containing Protein 952 3 | | FLJ906521 |
Export aliases for INO80E gene to outside databasesPrevious GC identifers: GC16P029916 GC16P027668 |
Summaries
for INO80E gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: IN80E_HUMAN, Q8NBZ0Function: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptionalregulation, DNA replication and probably DNA repair
|
Genomic Views
for INO80E gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the INO80E gene promoter:
COUP-TF1 COUP-TF COUP HNF-4alpha2 HNF-4alpha1
Other transcription factors
Search SABiosciences Chromatin IP Primers for INO80E
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INO80E |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p11.2 Ensembl cytogenetic band: 16p11.2 HGNC cytogenetic band: 16p11.2INO80E Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P030007: view genomic region
(about GC identifiers)
Start:
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30,006,615 bp from pter |
End:
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30,017,114 bp from pter |
Size:
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10,500 bases |
Orientation:
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plus strand |
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Proteins
for INO80E gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IN80E_HUMAN, Q8NBZ0 (See
protein sequence)Recommended Name: INO80 complex subunit E Size: 244 amino acids; 26478 Da
Subunit: Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with theN-terminus of INO80
Subcellular location: NucleusExplore the universe of human proteins at neXtProt for INO80E: NX_Q8NBZ0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NBZ0
INO80E Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_775889.1
ENSEMBL proteins: ENSP00000457016 ENSP00000303977 ENSP00000461808 ENSP00000454665 ENSP00000456073 ENSP00000454924 ENSP00000459432 ENSP00000458392
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
INO80E for ontologies About GeneDecksing
INO80E Antibody Products:
Assay Products for INO80E: |
Protein
Domains /
Families
for INO80E gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
INO80E for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8NBZ0ProtoNet protein and cluster: Q8NBZ0 |
Function
for INO80E gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: IN80E_HUMAN, Q8NBZ0Function: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptionalregulation, DNA replication and probably DNA repair
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for INO80E (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for INO80E
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: INO80E (NM_173618) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for INO80E | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INO80E |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INO80E |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- |
INO80E for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for INO80E:
|
Pathways & Interactions
for INO80E gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for INO80E
STRING Interaction
Network Preview (showing 5 interactants - click image to see 20)
5/24 Interacting proteins for INO80E (Q8NBZ01, 2, 3 ENSP000003039774) via UniProtKB, MINT, STRING, and/or I2D (see all 24)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
INO80E for ontologies About GeneDecksing
|
Drugs & Compounds
for INO80E gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for INO80E
Search CenterWatch for drugs/clinical trials and news about INO80E / IN80E
|
Transcripts
for INO80E gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for INO80E gene: NM_173618.1 Unigene Cluster for INO80E: INO80 complex subunit E Hs.434864 [show with all ESTs]Unigene Representative Sequence: AK07413713 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000563197(uc002dvg.1) ENST00000304516 ENST00000380503 ENST00000569957
ENST00000568043 ENST00000567254 ENST00000567065 ENST00000562441 ENST00000567705
ENST00000567987(uc002dvh.1) ENST00000563040 ENST00000540562 ENST00000562291
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for INO80E (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for INO80E
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: INO80E (NM_173618) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for INO80E | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INO80E |
Additional cDNA sequence: AK074033.1 AK074137.1 AK075133.1 AK097889.1 AK130409.1 AK309498.1 AY189289.1 BC035693.1 BC047712.2 23 DOTS entries: DT.95268337 DT.310247 DT.97854823 DT.91988194 DT.92439846 DT.92445465 DT.92070414 DT.92026640 DT.120696637 DT.100888197 DT.100888195 DT.100888203 DT.102842093 DT.102844277 DT.91791669 DT.91798357 DT.100888181 DT.100888183 DT.40131476 DT.100888179 DT.121617236 DT.92439845 DT.97772126 24/241 AceView cDNA sequences (see all 241): AI888349 CR620749 CB134006 BX334298 CB104593 BM671210 CR617333 CB216149 BX334297 AK097889 CR592457 AA729330 CR591225 BM718257 AK130409 AI202128 CR592458 CA952440 AI199037 AW515310 AA865742 AI923762 CB138972 CB068615
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for INO80E (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | · | 10d |
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | | | - | | - | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | - | | | | - | | - | | - | | - | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for INO80E
|
Expression
for INO80E gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| INO80E expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CACGGGTGTC
About this image
See INO80E Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for INO80E
SOURCE GeneReport for Unigene cluster: Hs.434864
SABiosciences Custom PCR Arrays for INO80E
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for INO80E
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat INO80E | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INO80E | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INO80E | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INO80E |
Orthologs
for INO80E gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for INO80E gene from 5/16 species (see all 16) About this table
ENSEMBL Gene Tree for INO80E (if available)
TreeFam Gene Tree for INO80E (if available) |
Paralogs
for INO80E gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for INO80E gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for INO80E (30006615 - 30017114 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for INO80E
1 CNV: 35383 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing INO80E |
|
Disorders
/ Diseases
for INO80E gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for INO80E gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for INO80E gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with INO80E) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex. (PubMed id 16230350)1, 2, 3 Jin J.... Conaway J.W. (2005)
- Subunit organization of the human INO80 chromatin remodeling complex: An evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. (PubMed id 21303910)1, 2 Chen L.... Conaway R.C. (2011)
- Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. (PubMed id 18922472)1, 2 Yao T....Conaway J.W. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Complementary quantitative proteomics reveals that tr anscription factor AP-4 mediates E-box-dependent complex formation for transcri ptional repression of HDM2. (PubMed id 19505873)1 Ku W.C....Chen Y.J. (2009)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PubMed id 17643375)1 Jeronimo C.... Coulombe B. (2007)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
|
External Searches for INO80E gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing INO80E gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing INO80E gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing INO80E gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for INO80E | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for INO80E gene:
Search GeneIP for patents involving INO80E
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for INO80E gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for INO80E | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for INO80E | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for INO80E | | | OriGene Protein Over-expression Lysate for INO80E | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for INO80E | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for INO80E | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for INO80E | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for INO80E | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for INO80E | | OriGene Custom Protein Services for INO80E | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat INO80E | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing INO80E | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INO80E | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat INO80E | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INO80E | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INO80E |
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| | | | Search Tocris compounds for INO80E |
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 | | | INO80E Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INO80E |
|  |  |  | | | | Search ThermoFisher Antibodies for INO80E |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INO80E |
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