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Aliases for INO80E Gene

Aliases for INO80E Gene

  • INO80 Complex Subunit E 2 3
  • Coiled-Coil Domain-Containing Protein 95 3 4
  • Coiled-Coil Domain Containing 95 2 3
  • CCDC95 3 4

External Ids for INO80E Gene

Previous HGNC Symbols for INO80E Gene

  • CCDC95

Previous GeneCards Identifiers for INO80E Gene

  • GC16P029916
  • GC16P027668

Summaries for INO80E Gene

GeneCards Summary for INO80E Gene

INO80E (INO80 Complex Subunit E) is a Protein Coding gene.

UniProtKB/Swiss-Prot for INO80E Gene

  • Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INO80E Gene

Genomics for INO80E Gene

Regulatory Elements for INO80E Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for INO80E Gene

Start:
29,995,294 bp from pter
End:
30,005,793 bp from pter
Size:
10,500 bases
Orientation:
Plus strand

Genomic View for INO80E Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for INO80E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INO80E Gene

Proteins for INO80E Gene

  • Protein details for INO80E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBZ0-IN80E_HUMAN
    Recommended name:
    INO80 complex subunit E
    Protein Accession:
    Q8NBZ0
    Secondary Accessions:
    • Q6Y2K3

    Protein attributes for INO80E Gene

    Size:
    244 amino acids
    Molecular mass:
    26478 Da
    Quaternary structure:
    • Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the N-terminus of INO80.

    Alternative splice isoforms for INO80E Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for INO80E Gene

Proteomics data for INO80E Gene at MOPED

Post-translational modifications for INO80E Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for INO80E Gene

Domains for INO80E Gene

Gene Families for INO80E Gene

HGNC:
  • INO80 :INO80 complex subunits

Protein Domains for INO80E Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for INO80E Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with INO80E: view

No data available for UniProtKB/Swiss-Prot for INO80E Gene

Function for INO80E Gene

Molecular function for INO80E Gene

UniProtKB/Swiss-Prot Function: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair

Gene Ontology (GO) - Molecular Function for INO80E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18922472
genes like me logo Genes that share ontologies with INO80E: view

Phenotypes for INO80E Gene

genes like me logo Genes that share phenotypes with INO80E: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for INO80E

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for INO80E Gene

Localization for INO80E Gene

Subcellular locations from UniProtKB/Swiss-Prot for INO80E Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for INO80E Gene COMPARTMENTS Subcellular localization image for INO80E gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for INO80E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0031011 Ino80 complex IDA 21303910
genes like me logo Genes that share ontologies with INO80E: view

Pathways for INO80E Gene

SuperPathways for INO80E Gene

No Data Available

Gene Ontology (GO) - Biological Process for INO80E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IEA --
GO:0006281 DNA repair IEA --
GO:0006310 DNA recombination IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with INO80E: view

No data available for Pathways by source for INO80E Gene

Transcripts for INO80E Gene

Unigene Clusters for INO80E Gene

INO80 complex subunit E:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for INO80E

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for INO80E Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d
SP1:
SP2: - - - - -
SP3: - - - - - -
SP4:
SP5: - - - -
SP6: - - - - -
SP7: - - - - - - -

Relevant External Links for INO80E Gene

GeneLoc Exon Structure for
INO80E
ECgene alternative splicing isoforms for
INO80E

Expression for INO80E Gene

mRNA expression in normal human tissues for INO80E Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for INO80E Gene

SOURCE GeneReport for Unigene cluster for INO80E Gene Hs.434864

genes like me logo Genes that share expressions with INO80E: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for INO80E Gene

Orthologs for INO80E Gene

This gene was present in the common ancestor of animals.

Orthologs for INO80E Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INO80E 35
  • 99.45 (n)
  • 99.18 (a)
INO80E 36
  • 82 (a)
OneToOne
cow
(Bos Taurus)
Mammalia INO80E 35
  • 92.08 (n)
  • 96.72 (a)
INO80E 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia INO80E 35
  • 92.9 (n)
  • 96.72 (a)
INO80E 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ino80e 35
  • 87.11 (n)
  • 92.27 (a)
Ino80e 16
Ino80e 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia INO80E 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia INO80E 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ino80e 35
  • 88.25 (n)
  • 94.26 (a)
lizard
(Anolis carolinensis)
Reptilia INO80E 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ino80e 35
  • 63.35 (n)
  • 63.2 (a)
zebrafish
(Danio rerio)
Actinopterygii ino80e 35
  • 55.95 (n)
  • 55.1 (a)
ino80e 36
  • 52 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG18004 36
  • 25 (a)
OneToOne
Species with no ortholog for INO80E:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for INO80E Gene

ENSEMBL:
Gene Tree for INO80E (if available)
TreeFam:
Gene Tree for INO80E (if available)

Paralogs for INO80E Gene

Selected SIMAP similar genes for INO80E Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with INO80E: view

No data available for Paralogs for INO80E Gene

Variants for INO80E Gene

Sequence variations from dbSNP and Humsavar for INO80E Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs4389160 -- 30,001,437(-) GGGAA(G/T)GGGGG reference, synonymous-codon, intron-variant, nc-transcript-variant
rs4787491 -- 30,004,016(+) AGGGT(A/G)AGTGA intron-variant, nc-transcript-variant
rs4788206 -- 29,998,382(+) ggtaa(A/G)aacag intron-variant
rs4788207 -- 29,998,953(+) ggcag(A/G)agaat intron-variant
rs4788208 -- 29,999,059(+) aaaaa(A/G)CACAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for INO80E Gene

Variant ID Type Subtype PubMed ID
nsv905717 CNV Loss 21882294
dgv2668n71 CNV Loss 21882294
esv997840 CNV Deletion 20482838

Relevant External Links for INO80E Gene

HapMap Linkage Disequilibrium report
INO80E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INO80E Gene

Disorders for INO80E Gene

No disorders were found for INO80E Gene.

No data available for UniProtKB/Swiss-Prot for INO80E Gene

Publications for INO80E Gene

  1. A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex. (PMID: 16230350) Jin J. … Conaway J.W. (J. Biol. Chem. 2005) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. (PMID: 18922472) Yao T. … Conaway J.W. (Mol. Cell 2008) 3 4
  5. Subunit organization of the human INO80 chromatin remodeling complex: An evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. (PMID: 21303910) Chen L. … Conaway R.C. (J. Biol. Chem. 2011) 3 4

Products for INO80E Gene

Sources for INO80E Gene

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