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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

INO80E Gene

protein-coding   GIFtS: 44
GCID: GC16P030007

INO80 Complex Subunit E

(Previous name: coiled-coil domain containing 95)
(Previous symbol: CCDC95)
  Search for INO80E
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
INO80 Complex Subunit E1 2
CCDC951 2 3
Coiled-Coil Domain Containing 951 2
Coiled-Coil Domain-Containing Protein 952 3

External Ids:    HGNC: 269051   Entrez Gene: 2838992   Ensembl: ENSG000001695927   UniProtKB: Q8NBZ03   

Export aliases for INO80E gene to outside databases

Previous GC identifers: GC16P029916 GC16P027668


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for INO80E Gene: 
INO80E (INO80 complex subunit E) is a protein-coding gene. GO annotations related to this gene include protein binding.

UniProtKB/Swiss-Prot: IN80E_HUMAN, Q8NBZ0
Function: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in
transcriptional regulation, DNA replication and probably DNA repair




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the INO80E gene promoter:
         COUP-TF1   COUP-TF   COUP   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidINO80E promoter sequence
   Search SABiosciences Chromatin IP Primers for INO80E

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INO80E


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

INO80E Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INO80E gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P030007:  view genomic region     (about GC identifiers)

Start:
30,006,615 bp from pter      End:
30,017,114 bp from pter
Size:
10,500 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IN80E_HUMAN, Q8NBZ0 (See protein sequence)
Recommended Name: INO80 complex subunit E  
Size: 244 amino acids; 26478 Da
Subunit: Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated
with the N-terminus of INO80
Subcellular location: Nucleus

Explore the universe of human proteins at neXtProt for INO80E: NX_Q8NBZ0

Explore proteomics data for INO80E at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8NBZ0

  • INO80E Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    INO80E Protein Expression
    REFSEQ proteins: NP_775889.1  
    ENSEMBL proteins: 
     ENSP00000457016   ENSP00000303977   ENSP00000461808   ENSP00000454665   ENSP00000456073  
     ENSP00000454924   ENSP00000459432   ENSP00000458392  

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    Novus Biologicals INO80E Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for INO80E 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0031011Ino80 complex IDA--

    INO80E for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    INO80: INO80 complex subunits

    1 InterPro protein domain:
     IPR026678 INO80E

    Graphical View of Domain Structure for InterPro Entry Q8NBZ0

    ProtoNet protein and cluster: Q8NBZ0


    INO80E for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IN80E_HUMAN, Q8NBZ0
    Function: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in
    transcriptional regulation, DNA replication and probably DNA repair

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18922472
         
    INO80E for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for INO80E:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for INO80E 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for INO80E

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for INO80E 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for INO80E 

    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate INO80E:
    hsa-miR-374c hsa-miR-22 hsa-miR-612 hsa-miR-655 hsa-miR-1285 hsa-miR-592
    SwitchGear 3'UTR luciferase reporter plasmidINO80E 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INO80E


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for INO80E

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/24 Interacting proteins for INO80E (Q8NBZ01, 2, 3 ENSP000003039774) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UCHL5Q9Y5K51, 3, ENSP000003564254EBI-769401,EBI-1051183 I2D: score=2 STRING: ENSP00000356425
    ACTR5Q9H9F93, ENSP000002439034I2D: score=2 STRING: ENSP00000243903
    MCRS1Q96EZ83, ENSP000003496404I2D: score=2 STRING: ENSP00000349640
    RUVBL2Q9Y2303, ENSP000002214134I2D: score=2 STRING: ENSP00000221413
    INO80CQ6PI983, ENSP000003914574I2D: score=1 STRING: ENSP00000391457
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006260DNA replication IEA--
    GO:0006281DNA repair IEA--
    GO:0006310DNA recombination IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    INO80E for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for INO80E (IN80E)

    Search CenterWatch for drugs/clinical trials and news about INO80E / IN80E

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for INO80E gene: 
    NM_173618.1  

    Unigene Cluster for INO80E:

    INO80 complex subunit E
    Hs.434864  [show with all ESTs]
    Unigene Representative Sequence: AK074137
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000563197(uc002dvg.1) ENST00000304516 ENST00000380503 ENST00000569957
    ENST00000568043 ENST00000567254 ENST00000567065 ENST00000562441 ENST00000567705
    ENST00000567987(uc002dvh.1) ENST00000563040 ENST00000540562 ENST00000562291

    miRNA
    Products:
         
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate INO80E:
    hsa-miR-374c hsa-miR-22 hsa-miR-612 hsa-miR-655 hsa-miR-1285 hsa-miR-592
    SwitchGear 3'UTR luciferase reporter plasmidINO80E 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INO80E
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INO80E

    Additional mRNA sequence: 

    AK074033.1 AK074137.1 AK075133.1 AK097889.1 AK130409.1 AK309498.1 AY189289.1 BC035693.1 
    BC047712.2 

    23 DOTS entries:

    DT.95268337  DT.310247  DT.97854823  DT.91988194  DT.92439846  DT.92445465  DT.92070414  DT.92026640 
    DT.120696637  DT.100888197  DT.100888195  DT.100888203  DT.102842093  DT.102844277  DT.91791669  DT.91798357 
    DT.100888179  DT.100888181  DT.100888183  DT.40131476  DT.121617236  DT.92439845  DT.97772126 

    24/241 AceView cDNA sequences (see all 241):

    CB104729 CD674647 AI274096 BC035693 BM911830 CR592458 AI923762 BU507969 
    AK074033 BU528528 CR620186 AI199037 BM923797 BM718379 CB134006 BU731500 
    AI369460 CR617333 AA865742 BM561121 BX334297 CA952440 AK075133 CR591225 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for INO80E (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d
    SP1:                                                                                                                  
    SP2:                                                  -           -     -     -     -                                 
    SP3:                                                  -           -     -     -     -     -                           
    SP4:                                                                                                                  
    SP5:                                                              -     -     -     -                                 


    ECgene alternative splicing isoforms for INO80E

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    INO80E expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACGGGTGTC
    INO80E Expression
    About this image


    See INO80E Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for INO80E

    SOURCE GeneReport for Unigene cluster: Hs.434864
        SABiosciences Custom PCR Arrays for INO80E
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INO80E

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for INO80E gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ino80e1 , 5 INO80 complex subunit E1, 5 87.11(n)1
    92.27(a)1
      7 (69.25 cM)5
    2338751  NM_153580.11  NP_705808.11 
     1268515805 
    lizard
    (Anolis carolinensis)
    Reptilia INO80E6
    Uncharacterized protein
    64(a)
    1 ↔ 1
    GL343606.1(315701-329533)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ625476.12   -- 75.97(n)    BJ625476.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ino80e1 INO80 complex subunit E 60.03(n)
    61.14(a)
      402932  NM_205636.1  NP_991199.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG180041 CG18004 47.03(n)
    42.57(a)
      36154  NM_136781.1  NP_610625.1 


    ENSEMBL Gene Tree for INO80E (if available)
    TreeFam Gene Tree for INO80E (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for INO80E gene
    2 SIMAP similar genes for INO80E using alignment to 7 protein entries:     IN80E_HUMAN (see all proteins):
    FLJ00210    FLJ00079

    INO80E for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/157 SNPs in INO80E are shown (see all 157)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1454423101,2
    --30009572(+) GCACTA/GCTGCA 1 -- int10--------
    rs80562161,2
    C,F--30009589(+) cctggG/Acaaca 1 -- int12Minor allele frequency- A:0.50WA CSA 4
    rs1435781661,2
    C--30009601(+) AGCCAA/GACTCC 1 -- int10--------
    rs1132557151,2
    C,F--30009622(+) AAAAAC/AAAAAA 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs47882061,2
    C,H--30009703(+) ggtaaG/Aaacag 1 -- int16Minor allele frequency- A:0.00NS EA NA 422
    rs1906118931,2
    --30009872(+) ATCCAA/GTTCAT 1 -- int10--------
    rs1829592331,2
    --30009906(+) TTTCCC/TCTTCT 1 -- int10--------
    rs1886450661,2
    --30010040(+) CATGTC/GACGTA 1 -- int10--------
    rs1171840451,2
    C,F--30010089(+) GGGCCG/AGGCAC 1 -- int11Minor allele frequency- A:0.01EA 120
    rs1923359081,2
    --30010132(+) GAGGCC/TGAGGC 1 -- int10--------

    HapMap Linkage Disequilibrium report for INO80E (30006615 - 30017114 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for INO80E:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv997840CNV Deletion20482838
    dgv2668n71CNV Loss21882294
    nsv905717CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for INO80E

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for INO80E gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with INO80E)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex. (PubMed id 16230350)1, 2, 3 Jin J.... Conaway J.W. (2005)
    2. Subunit organization of the human INO80 chromatin remodeling complex: An evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. (PubMed id 21303910)1, 2 Chen L.... Conaway R.C. (2011)
    3. Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. (PubMed id 18922472)1, 2 Yao T....Conaway J.W. (2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    7. Complementary quantitative proteomics reveals that tr anscription factor AP-4 mediates E-box-dependent complex formation for transcri ptional repression of HDM2. (PubMed id 19505873)1 Ku W.C....Chen Y.J. (2009)
    8. Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    10. Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PubMed id 17643375)1 Jeronimo C.... Coulombe B. (2007)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 283899 HGNC: 26905 AceView: FLJ90652 Ensembl:ENSG00000169592 euGenes: HUgn283899
    ECgene: INO80E H-InvDB: INO80E

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for INO80E Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for INO80E gene:
    Search GeneIP for patents involving INO80E

    GeneCards and IP:
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