INO80D Gene
protein-coding GIFtS: 41
GCID: GC02M206858
|
|
INO80 complex subunit D
| |
Aliases
for INO80D gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| INO80 Complex Subunit D1 2 | | FLJ203091 |
Export aliases for INO80D gene to outside databasesPrevious GC identifers: GC02M206566 GC02M198706 |
Summaries
for INO80D gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: IN80D_HUMAN, Q53TQ3Function: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptionalregulation, DNA replication and probably DNA repair
|
Genomic Views
for INO80D gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the INO80D gene promoter:
AML1a Pax-5 Cdc5 NF-kappaB Egr-4 COMP1 NF-kappaB2 ARP-1 NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for INO80D
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INO80D |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q33.3 Ensembl cytogenetic band: 2q33.3 HGNC cytogenetic band: 2q33.3INO80D Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M206858: view genomic region
(about GC identifiers)
Start:
|
206,858,445 bp from pter |
End:
|
206,951,027 bp from pter |
Size:
|
92,583 bases |
Orientation:
|
minus strand |
|
Proteins
for INO80D gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IN80D_HUMAN, Q53TQ3 (See
protein sequence)Recommended Name: INO80 complex subunit D Size: 878 amino acids; 98174 Da
Subunit: Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with theN-terminus of INO80
Subcellular location: Nucleus
Sequence caution: Sequence=AAH04193.2; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-Asequence; Sequence=AAH11687.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH11687.1;Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=AAH17290.2;Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=AAX93069.1;Type=Erroneous gene model prediction; Sequence=BAA91079.1; Type=Erroneous initiation; Note=Translation N-terminallyextended; Sequence=BAA91079.1; Type=Frameshift; Positions=513;
Secondary accessions: B3KU68 B9EG77 Q6PJC6 Q6PJU1 Q6PKA1 Q9NXD5Alternative splicing: 2 isoforms: Q53TQ3-1 Q53TQ3-2 Explore the universe of human proteins at neXtProt for INO80D: NX_Q53TQ3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q53TQ3
INO80D Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060229.3
ENSEMBL proteins: ENSP00000384198 ENSP00000402369 ENSP00000409031
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
INO80D for ontologies About GeneDecksing
INO80D Antibody Products:
Assay Products for INO80D: |
Protein
Domains /
Families
for INO80D gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
INO80D for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q53TQ3ProtoNet protein and cluster: Q53TQ3 UniProtKB/Swiss-Prot: IN80D_HUMAN, Q53TQ3Similarity: Belongs to the INO80D family |
Function
for INO80D gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: IN80D_HUMAN, Q53TQ3Function: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptionalregulation, DNA replication and probably DNA repair
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for INO80D (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for INO80D
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: INO80D (NM_017759) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for INO80D | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INO80D |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INO80D |
|
Pathways & Interactions
for INO80D gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for INO80D
STRING Interaction
Network Preview (showing 5 interactants - click image to see 16)
5/19 Interacting proteins for INO80D (Q53TQ33 ENSP000003841984) via UniProtKB, MINT, STRING, and/or I2D (see all 19)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006281 | DNA repair |
IEA | -- | | GO:0006310 | DNA recombination |
IEA | -- | | GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
INO80D for ontologies About GeneDecksing
|
Drugs & Compounds
for INO80D gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for INO80D
Search CenterWatch for drugs/clinical trials and news about INO80D / IN80D
|
Transcripts
for INO80D gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for INO80D gene: NM_017759.4 Unigene Cluster for INO80D: INO80 complex subunit D Hs.445036 [show with all ESTs]Unigene Representative Sequence: NM_0177593 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000403263(uc002vaz.4) ENST00000424117 ENST00000414320
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for INO80D (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for INO80D
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: INO80D (NM_017759) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for INO80D | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INO80D |
Additional cDNA sequence: AK000316.1 AK096585.1 AK225339.1 BC004193.2 BC011687.2 BC017290.2 BC136278.1 CR933609.1 JF736506.1 12 DOTS entries: DT.446363 DT.40310023 DT.91878686 DT.86836880 DT.40287535 DT.95261974 DT.439714 DT.91834091 DT.95150658 DT.100033487 DT.91656881 DT.91903267 24/26 AceView cDNA sequences (see all 26): AA258832 BC004193 AW504943 BC011687 BC017290 AK000316 AW847713 AI954752 AK096585 AI817469 BF308518 NM_017759 AW847921 AA258831 AW847851 BU661283 AW847718 BE297384 BE061066 BF911427 BG005151 BF327621 BF991512 BI055433
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for INO80D About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for INO80D
|
Expression
for INO80D gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| INO80D expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See INO80D Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for INO80D
SOURCE GeneReport for Unigene cluster: Hs.445036
SABiosciences Expression via Pathway-Focused PCR Array including INO80D: | Polycomb & Trithorax Complexes in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for INO80D
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat INO80D | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INO80D | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INO80D | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INO80D |
Orthologs
for INO80D gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for INO80D gene from 5/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
INO80D1 |
INO80 complex subunit D |
87.89(n)
92.01(a) |
|
424103 XM_421957.3 XP_421957.3 |
lizard
(Anolis carolinensis) |
Reptilia |
INO80D6 |
-- |
87(a) |
1 ↔ 1 |
GL343208.1(703542-723697) |
African clawed frog
(Xenopus laevis) |
Amphibia |
BJ032105.12 |
-- |
81.54(n) |
|
BJ032105.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.132182 |
Transcribed sequences |
80(n) |
|
BI877332.1 |
honey bee
(Apis mellifera) |
Insecta |
-- |
-- |
22(a) |
1 ↔ 1 |
Group5.15(7182-9331) |
ENSEMBL Gene Tree for INO80D (if available)
TreeFam Gene Tree for INO80D (if available) |
Paralogs
for INO80D gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for INO80D gene
- KANSL22
INO80D for paralogs About GeneDecksing
|
Genomic Variants
for INO80D gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for INO80D (206858445 - 206951027 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for INO80D: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing INO80D |
|
Disorders
/ Diseases
for INO80D gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
INO80D for disorders About GeneDecksing
1  disease for INO80D: About MalaCardsobesity
Export disorders for INO80D gene to outside databases
|
Publications
for INO80D gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for INO80D gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with INO80D) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex. (PubMed id 16230350)1, 2, 3 Jin J.... Conaway J.W. (2005)
- Subunit organization of the human INO80 chromatin remodeling complex: An evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. (PubMed id 21303910)1, 2 Chen L.... Conaway R.C. (2011)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
- Common body mass index-associated variants confer ris k of extreme obesity. (PubMed id 19553259)1 Cotsapas C....Daly M.J. (2009)
- Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. (PubMed id 18922472)2 Yao T....Conaway J.W. (2008)
- YY1 functions with INO80 to activate transcription. (PubMed id 17721549)1 Cai Y.... Conaway J.W. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
|
External Searches for INO80D gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing INO80D gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing INO80D gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing INO80D gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for INO80D | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for INO80D gene:
Search GeneIP for patents involving INO80D
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for INO80D gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for INO80D | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for INO80D | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for INO80D | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for INO80D | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for INO80D | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for INO80D | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat INO80D | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing INO80D | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INO80D | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat INO80D | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INO80D | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INO80D |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INO80D |
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