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Aliases for INO80D Gene

Aliases for INO80D Gene

  • INO80 Complex Subunit D 2 3 5

External Ids for INO80D Gene

Previous GeneCards Identifiers for INO80D Gene

  • GC02M206566
  • GC02M206858
  • GC02M198706

Summaries for INO80D Gene

GeneCards Summary for INO80D Gene

INO80D (INO80 Complex Subunit D) is a Protein Coding gene. Among its related pathways are Transcription-Coupled Nucleotide Excision Repair (TC-NER) and DNA Double-Strand Break Repair. An important paralog of this gene is KANSL2.

UniProtKB/Swiss-Prot for INO80D Gene

  • Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

Additional gene information for INO80D Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INO80D Gene

Genomics for INO80D Gene

Regulatory Elements for INO80D Gene

Enhancers for INO80D Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H206157 1.4 ENCODE dbSUPER 21 -73.4 -73388 3 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 NDUFS1 INO80D GCSHP3 ENSG00000231955 ENSG00000227946 GC02P206176 GC02P206174
GH02H205885 0.9 ENCODE 19 +200.5 200532 0 RB1 ZNF76 KLF17 ZNF2 RAD21 ZNF366 ZNF143 KLF7 ZNF391 EGR2 INO80D ENSG00000225216 NRP2 GC02P205893 LOC105373847
GH02H205720 1 ENCODE dbSUPER 10.5 +364.8 364753 2 CTCF EBF1 BATF CTBP1 POLR2A EED RUNX3 IKZF2 CREM SMARCE1 NRP2 INO80D GC02P205736
GH02H205711 1.8 FANTOM5 Ensembl ENCODE dbSUPER 2.6 +372.7 372740 4 BATF ZNF143 FOS RUNX3 IKZF2 CREM SMARCA5 JUNB ELF1 ZNF623 NRP2 ENSG00000225216 INO80D GC02P205736
GH02H205695 1.8 FANTOM5 Ensembl ENCODE dbSUPER 2.1 +386.1 386106 9 FOXA2 ATF1 TBL1XR1 BATF RAD21 RARA FOS ATF7 RUNX3 CREM ENSG00000225216 NRP2 INO80D GC02P205736
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around INO80D on UCSC Golden Path with GeneCards custom track

Promoters for INO80D Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000129316 503 4001 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 SP5

Genomic Location for INO80D Gene

Chromosome:
2
Start:
205,993,721 bp from pter
End:
206,086,303 bp from pter
Size:
92,583 bases
Orientation:
Minus strand

Genomic View for INO80D Gene

Genes around INO80D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INO80D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INO80D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INO80D Gene

Proteins for INO80D Gene

  • Protein details for INO80D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53TQ3-IN80D_HUMAN
    Recommended name:
    INO80 complex subunit D
    Protein Accession:
    Q53TQ3
    Secondary Accessions:
    • B3KU68
    • B9EG77
    • Q6PJC6
    • Q6PJU1
    • Q6PKA1
    • Q9NXD5

    Protein attributes for INO80D Gene

    Size:
    878 amino acids
    Molecular mass:
    98174 Da
    Quaternary structure:
    • Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the N-terminus of INO80.
    SequenceCaution:
    • Sequence=AAH04193.2; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH11687.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH11687.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH17290.2; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAX93069.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA91079.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91079.1; Type=Frameshift; Positions=513; Evidence={ECO:0000305};

    Alternative splice isoforms for INO80D Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for INO80D Gene

Post-translational modifications for INO80D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for INO80D Gene

Domains & Families for INO80D Gene

Gene Families for INO80D Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for INO80D Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for INO80D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q53TQ3

UniProtKB/Swiss-Prot:

IN80D_HUMAN :
  • Belongs to the INO80D family.
Family:
  • Belongs to the INO80D family.
genes like me logo Genes that share domains with INO80D: view

Function for INO80D Gene

Molecular function for INO80D Gene

UniProtKB/Swiss-Prot Function:
Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

Phenotypes From GWAS Catalog for INO80D Gene

Phenotypes for INO80D Gene

genes like me logo Genes that share phenotypes with INO80D: view

Animal Model Products

CRISPR Products

miRNA for INO80D Gene

miRTarBase miRNAs that target INO80D

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for INO80D
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for INO80D Gene

Localization for INO80D Gene

Subcellular locations from UniProtKB/Swiss-Prot for INO80D Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for INO80D gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for INO80D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with INO80D: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for INO80D Gene

Pathways & Interactions for INO80D Gene

genes like me logo Genes that share pathways with INO80D: view

Pathways by source for INO80D Gene

Gene Ontology (GO) - Biological Process for INO80D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006310 DNA recombination IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006974 cellular response to DNA damage stimulus IEA --
genes like me logo Genes that share ontologies with INO80D: view

No data available for SIGNOR curated interactions for INO80D Gene

Drugs & Compounds for INO80D Gene

No Compound Related Data Available

Transcripts for INO80D Gene

Unigene Clusters for INO80D Gene

INO80 complex subunit D:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for INO80D
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for INO80D Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1:
SP2:
SP3: -

Relevant External Links for INO80D Gene

GeneLoc Exon Structure for
INO80D
ECgene alternative splicing isoforms for
INO80D

Expression for INO80D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for INO80D Gene

Protein differential expression in normal tissues from HIPED for INO80D Gene

This gene is overexpressed in Heart (21.4), Pancreas (16.1), Urinary Bladder (14.2), and Adrenal (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for INO80D Gene



NURSA nuclear receptor signaling pathways regulating expression of INO80D Gene:

INO80D

SOURCE GeneReport for Unigene cluster for INO80D Gene:

Hs.445036

Evidence on tissue expression from TISSUES for INO80D Gene

  • Nervous system(4.4)
  • Muscle(4.2)
genes like me logo Genes that share expression patterns with INO80D: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for INO80D Gene

Orthologs for INO80D Gene

This gene was present in the common ancestor of animals.

Orthologs for INO80D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INO80D 33 34
  • 99.77 (n)
dog
(Canis familiaris)
Mammalia INO80D 33 34
  • 95.39 (n)
oppossum
(Monodelphis domestica)
Mammalia INO80D 34
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia INO80D 33 34
  • 92.91 (n)
rat
(Rattus norvegicus)
Mammalia Ino80d 33
  • 91.48 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia INO80D 34
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ino80d 33 16 34
  • 90.7 (n)
chicken
(Gallus gallus)
Aves INO80D 33 34
  • 87.75 (n)
lizard
(Anolis carolinensis)
Reptilia INO80D 34
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ino80d 33
  • 74.31 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC555228 33
  • 61.31 (n)
ino80da 34
  • 57 (a)
OneToMany
ino80db 34
  • 49 (a)
OneToMany
Dr.13218 33
fruit fly
(Drosophila melanogaster)
Insecta dgt1 34
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 15 (a)
OneToMany
Species where no ortholog for INO80D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for INO80D Gene

ENSEMBL:
Gene Tree for INO80D (if available)
TreeFam:
Gene Tree for INO80D (if available)

Paralogs for INO80D Gene

Paralogs for INO80D Gene

genes like me logo Genes that share paralogs with INO80D: view

Variants for INO80D Gene

Sequence variations from dbSNP and Humsavar for INO80D Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000023869 -- 206,000,500(+) GAATG(G/T)TATAG utr-variant-3-prime
rs1000060084 -- 206,005,846(+) GACTA(C/T)GTGAT intron-variant
rs1000118195 -- 206,000,302(+) ACCCA(G/T)AGCGA utr-variant-3-prime
rs1000146949 -- 206,085,560(+) CCGTG(A/G)GGCCT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000148194 -- 206,045,400(+) TGCTG(A/G)ATATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for INO80D Gene

Variant ID Type Subtype PubMed ID
esv2665558 CNV deletion 23128226
esv3594060 CNV loss 21293372
nsv1073008 CNV deletion 25765185
nsv508196 CNV deletion 20534489

Variation tolerance for INO80D Gene

Residual Variation Intolerance Score: 11.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.79; 91.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for INO80D Gene

Human Gene Mutation Database (HGMD)
INO80D
SNPedia medical, phenotypic, and genealogical associations of SNPs for
INO80D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INO80D Gene

Disorders for INO80D Gene

Relevant External Links for INO80D

Genetic Association Database (GAD)
INO80D
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
INO80D

No disorders were found for INO80D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for INO80D Gene

Publications for INO80D Gene

  1. A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex. (PMID: 16230350) Jin J … Conaway JW (The Journal of biological chemistry 2005) 2 3 4 60
  2. Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. (PMID: 21303910) Chen L … Conaway RC (The Journal of biological chemistry 2011) 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for INO80D Gene

Sources for INO80D Gene

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