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Aliases for INO80D Gene

Aliases for INO80D Gene

  • INO80 Complex Subunit D 2 3

External Ids for INO80D Gene

Previous GeneCards Identifiers for INO80D Gene

  • GC02M206566
  • GC02M206858
  • GC02M198706

Summaries for INO80D Gene

GeneCards Summary for INO80D Gene

INO80D (INO80 Complex Subunit D) is a Protein Coding gene. Among its related pathways are DNA Double-Strand Break Repair and Transcription-Coupled Nucleotide Excision Repair (TC-NER). An important paralog of this gene is KANSL2.

UniProtKB/Swiss-Prot for INO80D Gene

  • Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INO80D Gene

Genomics for INO80D Gene

Regulatory Elements for INO80D Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for INO80D Gene

Chromosome:
2
Start:
205,993,721 bp from pter
End:
206,086,303 bp from pter
Size:
92,583 bases
Orientation:
Minus strand

Genomic View for INO80D Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for INO80D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INO80D Gene

Proteins for INO80D Gene

  • Protein details for INO80D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53TQ3-IN80D_HUMAN
    Recommended name:
    INO80 complex subunit D
    Protein Accession:
    Q53TQ3
    Secondary Accessions:
    • B3KU68
    • B9EG77
    • Q6PJC6
    • Q6PJU1
    • Q6PKA1
    • Q9NXD5

    Protein attributes for INO80D Gene

    Size:
    878 amino acids
    Molecular mass:
    98174 Da
    Quaternary structure:
    • Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the N-terminus of INO80.
    SequenceCaution:
    • Sequence=AAH04193.2; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH11687.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH11687.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH17290.2; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAX93069.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA91079.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91079.1; Type=Frameshift; Positions=513; Evidence={ECO:0000305};

    Alternative splice isoforms for INO80D Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for INO80D Gene

Proteomics data for INO80D Gene at MOPED

Post-translational modifications for INO80D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for INO80D Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for INO80D Gene

Domains & Families for INO80D Gene

Gene Families for INO80D Gene

Protein Domains for INO80D Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for INO80D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q53TQ3

UniProtKB/Swiss-Prot:

IN80D_HUMAN :
  • Belongs to the INO80D family.
Family:
  • Belongs to the INO80D family.
genes like me logo Genes that share domains with INO80D: view

Function for INO80D Gene

Molecular function for INO80D Gene

UniProtKB/Swiss-Prot Function:
Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair

Phenotypes for INO80D Gene

GenomeRNAi human phenotypes for INO80D:
genes like me logo Genes that share phenotypes with INO80D: view

miRNA for INO80D Gene

miRTarBase miRNAs that target INO80D

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for INO80D

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for INO80D Gene

Localization for INO80D Gene

Subcellular locations from UniProtKB/Swiss-Prot for INO80D Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for INO80D Gene COMPARTMENTS Subcellular localization image for INO80D gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for INO80D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with INO80D: view

Pathways & Interactions for INO80D Gene

genes like me logo Genes that share pathways with INO80D: view

Pathways by source for INO80D Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Polycomb & Trithorax Complexes in human,mouse,rat

Gene Ontology (GO) - Biological Process for INO80D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006310 DNA recombination IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with INO80D: view

No data available for SIGNOR curated interactions for INO80D Gene

Drugs & Compounds for INO80D Gene

No Compound Related Data Available

Transcripts for INO80D Gene

Unigene Clusters for INO80D Gene

INO80 complex subunit D:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for INO80D

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for INO80D Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1:
SP2:
SP3: -

Relevant External Links for INO80D Gene

GeneLoc Exon Structure for
INO80D
ECgene alternative splicing isoforms for
INO80D

Expression for INO80D Gene

mRNA expression in normal human tissues for INO80D Gene

Protein differential expression in normal tissues from HIPED for INO80D Gene

This gene is overexpressed in Heart (21.4), Pancreas (16.1), Urinary Bladder (14.2), and Adrenal (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for INO80D Gene



SOURCE GeneReport for Unigene cluster for INO80D Gene Hs.445036

genes like me logo Genes that share expression patterns with INO80D: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for INO80D Gene

Orthologs for INO80D Gene

This gene was present in the common ancestor of animals.

Orthologs for INO80D Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia INO80D 35
  • 92.91 (n)
  • 95.71 (a)
INO80D 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia INO80D 35
  • 95.39 (n)
  • 96.98 (a)
INO80D 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ino80d 35
  • 90.7 (n)
  • 94.52 (a)
Ino80d 16
Ino80d 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia INO80D 35
  • 99.77 (n)
  • 99.9 (a)
INO80D 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ino80d 35
  • 91.48 (n)
  • 95.59 (a)
oppossum
(Monodelphis domestica)
Mammalia INO80D 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia INO80D 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves INO80D 35
  • 87.75 (n)
  • 91.81 (a)
INO80D 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia INO80D 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ino80d 35
  • 74.31 (n)
  • 76.47 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.13218 35
LOC555228 35
  • 61.31 (n)
  • 63.63 (a)
ino80da 36
  • 57 (a)
OneToMany
ino80db 36
  • 49 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta dgt1 36
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 15 (a)
OneToMany
Species with no ortholog for INO80D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for INO80D Gene

ENSEMBL:
Gene Tree for INO80D (if available)
TreeFam:
Gene Tree for INO80D (if available)

Paralogs for INO80D Gene

Paralogs for INO80D Gene

genes like me logo Genes that share paralogs with INO80D: view

Variants for INO80D Gene

Sequence variations from dbSNP and Humsavar for INO80D Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs713106 -- 205,997,280(+) CAATT(C/T)TCCTA utr-variant-3-prime
rs817990 -- 206,009,277(+) CACTT(A/G)GCCTG intron-variant
rs817991 -- 206,009,615(+) CTGGC(A/G)GGCAT reference, synonymous-codon
rs817992 -- 206,011,535(+) TATTC(A/G)CTCCC intron-variant
rs817993 -- 206,012,202(+) aaaat(A/G)cagaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for INO80D Gene

Variant ID Type Subtype PubMed ID
nsv875733 CNV Gain 21882294
nsv508196 CNV Loss 20534489
esv2665558 CNV Deletion 23128226

Variation tolerance for INO80D Gene

Residual Variation Intolerance Score: 11.66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.79; 91.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for INO80D Gene

HapMap Linkage Disequilibrium report
INO80D
Human Gene Mutation Database (HGMD)
INO80D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INO80D Gene

Disorders for INO80D Gene

Relevant External Links for INO80D

Genetic Association Database (GAD)
INO80D
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
INO80D
genes like me logo Genes that share disorders with INO80D: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for INO80D Gene

Publications for INO80D Gene

  1. A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex. (PMID: 16230350) Jin J. … Conaway J.W. (J. Biol. Chem. 2005) 2 67
  2. Whole exome sequencing implicates an INO80D mutation in a syndrome of aortic hypoplasia, premature atherosclerosis, and arterial stiffness. (PMID: 25122053) Shameer K. … Kullo I.J. (Circ Cardiovasc Genet 2014) 67
  3. Subunit organization of the human INO80 chromatin remodeling complex: An evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. (PMID: 21303910) Chen L. … Conaway R.C. (J. Biol. Chem. 2011) 67
  4. Common body mass index-associated variants confer risk of extreme obesity. (PMID: 19553259) Cotsapas C. … Daly M.J. (Hum. Mol. Genet. 2009) 67
  5. Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. (PMID: 18922472) Yao T. … Conaway J.W. (Mol. Cell 2008) 67

Products for INO80D Gene

Sources for INO80D Gene

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