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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

INO80C Gene

protein-coding   GIFtS: 47
GCID: GC18M033034

INO80 Complex Subunit C

(Previous name: chromosome 18 open reading frame 37)
(Previous symbol: C18orf37)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
INO80 Complex Subunit C1 2     Chromosome 18 Open Reading Frame 371
C18orf371 2 3     IES6 Homolog (S. Cerevisiae)1
hIes62 3     IES62
IES6 Homolog2 3     

External Ids:    HGNC: 269941   Entrez Gene: 1254762   Ensembl: ENSG000001533917   UniProtKB: Q6PI983   

Export aliases for INO80C gene to outside databases

Previous GC identifers: GC18M031289 GC18M029908


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for INO80C Gene: 
INO80C (INO80 complex subunit C) is a protein-coding gene. Diseases associated with INO80C include gastric cancer. GO annotations related to this gene include molecular_function. An important paralog of this gene is ENSG00000267140.

UniProtKB/Swiss-Prot: IN80C_HUMAN, Q6PI98
Function: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional
regulation, DNA replication and probably DNA repair




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NT_010966.14  NC_018929.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the INO80C gene promoter:
         Nkx3-1   STAT1   Nkx3-1 v4   STAT1beta   FOXD1   Nkx3-1 v1   STAT1alpha   N-Myc   Nkx3-1 v2   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidINO80C promoter sequence
   Search SABiosciences Chromatin IP Primers for INO80C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INO80C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q12.2   Ensembl cytogenetic band:  18q12.2   HGNC cytogenetic band: 18q12.2

INO80C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INO80C gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M033034:  view genomic region     (about GC identifiers)

Start:
33,032,194 bp from pter      End:
33,077,955 bp from pter
Size:
45,762 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IN80C_HUMAN, Q6PI98 (See protein sequence)
Recommended Name: INO80 complex subunit C  
Size: 192 amino acids; 20643 Da
Subunit: Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated
with the helicase ATP-binding and the helicase C-terminal domain of INO80. Component of some MLL1/MLL complex, at
least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative
components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31,
RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10
Subcellular location: Nucleus
Secondary accessions: B4DUI4 E9PCS7 Q86WR1 Q8N994
Alternative splicing: 3 isoforms:  Q6PI98-1   Q6PI98-3   Q6PI98-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for INO80C: NX_Q6PI98

Explore proteomics data for INO80C at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6PI98

  • INO80C Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    INO80C Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001092287.1  NP_919257.2  

    ENSEMBL proteins: 
     ENSP00000465273   ENSP00000334473   ENSP00000467708   ENSP00000391457   ENSP00000464948  
     ENSP00000467013   ENSP00000473165   ENSP00000466269   ENSP00000465637  

    Human Recombinant Protein Products for INO80C: 
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    OriGene Protein Over-expression Lysate for INO80C
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    OriGene Custom Protein Services for INO80C
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    Novus Biologicals INO80C Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for INO80C 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IDA--
    GO:0031011Ino80 complex IDA--
    GO:0071339MLL1 complex IDA15960975

    INO80C for ontologies           About GeneDecksing



    INO80C Antibody Products: 
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    Assay Products for INO80C: 
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    Cloud-Clone Corp. ELISAs for INO80C 
    Cloud-Clone Corp. CLIAs for INO80C


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    INO80: INO80 complex subunits

    1 InterPro protein domain:
     IPR013272 YL1_C

    Graphical View of Domain Structure for InterPro Entry Q6PI98

    ProtoNet protein and cluster: Q6PI98


    INO80C for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IN80C_HUMAN, Q6PI98
    Function: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional
    regulation, DNA replication and probably DNA repair

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    INO80C for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for INO80C:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for INO80C 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for INO80C

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for INO80C 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for INO80C 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat INO80C
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate INO80C:
    hsa-miR-1304 hsa-miR-124 hsa-miR-196a* hsa-miR-506 hsa-miR-32* hsa-miR-432 hsa-miR-543 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidINO80C 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Clone
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INO80C
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    Sirion Biotech Customized lentivirus for stable overexpression of INO80C 
                         Customized lentivirus expression plasmids for stable overexpression of INO80C 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INO80C


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for INO80C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/44 Interacting proteins for INO80C (Q6PI982, 3 ENSP000003914574) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SAT1P216732, 3, ENSP000003685724MINT-63573 I2D: score=4 STRING: ENSP00000368572
    ACTR5Q9H9F93, ENSP000002439034I2D: score=1 STRING: ENSP00000243903
    H2AFZP0C0S53, ENSP000002964174I2D: score=1 STRING: ENSP00000296417
    MCRS1Q96EZ83, ENSP000003496404I2D: score=1 STRING: ENSP00000349640
    RUVBL2Q9Y2303, ENSP000002214134I2D: score=1 STRING: ENSP00000221413
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair IEA--
    GO:0006310DNA recombination IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0008150biological_process ND--

    INO80C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for INO80C (IN80C)

    Search CenterWatch for drugs/clinical trials and news about INO80C / IN80C

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for INO80C gene (2 alternative transcripts): 
    NM_001098817.1  NM_194281.3  

    Unigene Cluster for INO80C:

    INO80 complex subunit C
    Hs.464903  [show with all ESTs]
    Unigene Representative Sequence: NM_001098817
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000592173 ENST00000334598(uc002kyx.4 uc002kyy.4) ENST00000590757
    ENST00000441607(uc010dmt.3) ENST00000586489 ENST00000587450 ENST00000591139
    ENST00000283410(uc002kyw.1) ENST00000586449 ENST00000589273 ENST00000585971
    ENST00000589053
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat INO80C
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate INO80C:
    hsa-miR-1304 hsa-miR-124 hsa-miR-196a* hsa-miR-506 hsa-miR-32* hsa-miR-432 hsa-miR-543 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidINO80C 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for INO80C
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat INO80C
    Clone
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    OriGene clones in human, mouse for INO80C (see all 13)
    OriGene ORF clones in mouse, rat for INO80C
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): INO80C (NM_194281)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INO80C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INO80C
    Sirion Biotech Customized lentivirus for stable overexpression of INO80C 
                         Customized lentivirus expression plasmids for stable overexpression of INO80C 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for INO80C
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat INO80C
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INO80C
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INO80C

    Additional mRNA sequence: 

    AK300660.1 BC039404.1 

    9 DOTS entries:

    DT.40125701  DT.91650206  DT.95344417  DT.100749613  DT.121097593  DT.121097595  DT.97843610  DT.100749614 
    DT.100774003 

    24/71 AceView cDNA sequences (see all 71):

    CR623740 BX110111 BQ951150 BQ887287 CB128122 NM_194281 AA315519 BM758057 
    BX377658 BC039404 BM548531 BU621388 BC048989 BM466146 BM758571 BM818578 
    BM755745 BI601461 AW105389 BM756682 BM770388 BG910475 BI831479 AI400767 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for INO80C (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b
    SP1:                                      -     -           -     -                                   -                                             
    SP2:                                                  -     -     -     -     -                       -                                             
    SP3:                                                                                                  -                                             
    SP4:                                      -     -     -     -     -     -     -                       -                 -     -     -               
    SP5:                                      -     -     -     -     -     -     -                       -                                             


    ECgene alternative splicing isoforms for INO80C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    INO80C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTTGTTTC
    INO80C Expression
    About this image


    See INO80C Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for INO80C

    SOURCE GeneReport for Unigene cluster: Hs.464903
        SABiosciences Expression via Pathway-Focused PCR Array including INO80C: 
              Polycomb & Trithorax Complexes in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INO80C
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INO80C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for INO80C gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ino80c1 , 5 INO80 complex subunit C1, 5 87.78(n)1
    91.1(a)1
      18 (12.74 cM)5
    2252801  NM_172625.21  NP_766213.11 
     241047575 
    chicken
    (Gallus gallus)
    Aves INO80C1 INO80 complex subunit C 73.01(n)
    76.63(a)
      420956  XM_419041.3  XP_419041.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    59(a)
    1 → many
    2(112678398-112678973)
    zebrafish
    (Danio rerio)
    Actinopterygii wufj61b082 Transcribed sequences 75.22(n)    BM571379.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG126596
    --
    45(a)
    1 → many
    X(8484649-8486423)


    ENSEMBL Gene Tree for INO80C (if available)
    TreeFam Gene Tree for INO80C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for INO80C gene
    ENSG000002671402  

    INO80C for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/581 SNPs in INO80C are shown (see all 581)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs129701101,2
    C,H--33047796(+) TCCAGA/TAGCCC 2 -- ds50014Minor allele frequency- T:0.00NS EA 420
    rs748872371,2
    C,F--33047804(+) CCCCAG/CGGCCT 2 -- ds50011Minor allele frequency- C:0.15WA 118
    rs729589951,2
    C,F--33048050(+) GAGGCC/TGATCT 2 -- ds50011Minor allele frequency- T:0.02NA 120
    rs72306161,2
    C,F,A--33048070(+) GCACAT/CGTGAG 2 -- ds500110Minor allele frequency- C:0.43NA WA CSA EA 372
    rs1170859661,2
    C,F--33048129(+) ACCCAA/GTTTTG 2 -- ds50011Minor allele frequency- G:0.03NA 120
    rs1464398141,2
    --33048386(+) GAAATA/TTCACA 2 -- ut310--------
    rs1922925941,2
    --33048398(+) TTGGAA/GGGAAA 2 -- ut310--------
    rs116597691,2
    C,F,A,H--33048401(+) GAGGGA/GAAACA 2 -- ut31 trp325Minor allele frequency- G:0.10NA NS EA WA 2902
    rs596919051,2
    C--33048413(+) ACACT-/AAAAAA 2 -- ut312Minor allele frequency- A:0.00NA CSA 4
    rs30881821,2
    C,F,A,H--33048554(+) TTCCAC/TTTCAT 2 -- ut3127Minor allele frequency- T:0.27MN NA NS EA CSA WA EU 3999

    HapMap Linkage Disequilibrium report for INO80C (33032194 - 33077955 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for INO80C:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv2252CNV Loss18451855

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing INO80C
    DNA2.0 Custom Variant and Variant Library Synthesis for INO80C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for INO80C:    About MalaCards
    gastric cancer    


    INO80C for disorders           About GeneDecksing

    Genetic Association Database (GAD): INO80C

    Export disorders for INO80C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for INO80C gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with INO80C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex. (PubMed id 16230350)1, 2, 3 Jin J.... Conaway J.W. (2005)
    2. Subunit organization of the human INO80 chromatin remodeling complex: An evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. (PubMed id 21303910)1, 2 Chen L.... Conaway R.C. (2011)
    3. Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. (PubMed id 18922472)1, 2 Yao T....Conaway J.W. (2008)
    4. Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PubMed id 17370265)1, 2 Denis N.J.... Figeys D. (2007)
    5. Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. (PubMed id 15960975)1, 2 Dou Y.... Roeder R.G. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 125476 HGNC: 26994 AceView: C18orf37 Ensembl:ENSG00000153391 euGenes: HUgn125476
    ECgene: INO80C H-InvDB: INO80C

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for INO80C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for INO80C gene:
    Search GeneIP for patents involving INO80C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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