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Aliases for INO80C Gene

Aliases for INO80C Gene

  • INO80 Complex Subunit C 2 3
  • IES6 Homolog 3 4
  • C18orf37 3 4
  • HIes6 3 4
  • Chromosome 18 Open Reading Frame 37 2
  • IES6 Homolog (S. Cerevisiae) 2
  • IES6 3

External Ids for INO80C Gene

Previous HGNC Symbols for INO80C Gene

  • C18orf37

Previous GeneCards Identifiers for INO80C Gene

  • GC18M031289
  • GC18M033034
  • GC18M029908

Summaries for INO80C Gene

GeneCards Summary for INO80C Gene

INO80C (INO80 Complex Subunit C) is a Protein Coding gene. An important paralog of this gene is ENSG00000267140.

UniProtKB/Swiss-Prot for INO80C Gene

  • Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INO80C Gene

Genomics for INO80C Gene

Regulatory Elements for INO80C Gene

Genomic Location for INO80C Gene

Start:
35,452,230 bp from pter
End:
35,498,144 bp from pter
Size:
45,915 bases
Orientation:
Minus strand

Genomic View for INO80C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for INO80C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INO80C Gene

Proteins for INO80C Gene

  • Protein details for INO80C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PI98-IN80C_HUMAN
    Recommended name:
    INO80 complex subunit C
    Protein Accession:
    Q6PI98
    Secondary Accessions:
    • B4DUI4
    • E9PCS7
    • Q86WR1
    • Q8N994

    Protein attributes for INO80C Gene

    Size:
    192 amino acids
    Molecular mass:
    20643 Da
    Quaternary structure:
    • Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the helicase ATP-binding and the helicase C-terminal domain of INO80. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10.

    Alternative splice isoforms for INO80C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for INO80C Gene

Proteomics data for INO80C Gene at MOPED

Post-translational modifications for INO80C Gene

  • Ubiquitination at Lys21, Lys22, and Lys41
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for INO80C Gene

Domains for INO80C Gene

Gene Families for INO80C Gene

HGNC:
  • INO80 :INO80 complex subunits

Protein Domains for INO80C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for INO80C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with INO80C: view

No data available for UniProtKB/Swiss-Prot for INO80C Gene

Function for INO80C Gene

Molecular function for INO80C Gene

UniProtKB/Swiss-Prot Function: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair

Gene Ontology (GO) - Molecular Function for INO80C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with INO80C: view

Phenotypes for INO80C Gene

GenomeRNAi human phenotypes for INO80C:
genes like me logo Genes that share phenotypes with INO80C: view

miRNA for INO80C Gene

miRTarBase miRNAs that target INO80C

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for INO80C Gene

Localization for INO80C Gene

Subcellular locations from UniProtKB/Swiss-Prot for INO80C Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for INO80C Gene COMPARTMENTS Subcellular localization image for INO80C gene
Compartment Confidence
nucleus 5
mitochondrion 3

Gene Ontology (GO) - Cellular Components for INO80C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0031011 Ino80 complex IDA 21303910
GO:0071339 MLL1 complex IDA 15960975
genes like me logo Genes that share ontologies with INO80C: view

Pathways for INO80C Gene

SuperPathways for INO80C Gene

No Data Available

Gene Ontology (GO) - Biological Process for INO80C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006310 DNA recombination IEA --
GO:0006338 chromatin remodeling IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with INO80C: view

No data available for Pathways by source for INO80C Gene

Transcripts for INO80C Gene

Unigene Clusters for INO80C Gene

INO80 complex subunit C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for INO80C Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b
SP1: - - - - -
SP2: - - - - - -
SP3: -
SP4: - - - - - - - - - - -
SP5: - - - - - - - -
SP6: - - -
SP7: - - - - - - -
SP8: - - - - -
SP9: - - - - - - - - - - - - - -
SP10: - - - - - - - - - - -
SP11: - -
SP12: - - - - - - - - - - - - -

Relevant External Links for INO80C Gene

GeneLoc Exon Structure for
INO80C
ECgene alternative splicing isoforms for
INO80C

Expression for INO80C Gene

mRNA expression in normal human tissues for INO80C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for INO80C Gene

SOURCE GeneReport for Unigene cluster for INO80C Gene Hs.464903

genes like me logo Genes that share expressions with INO80C: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for INO80C Gene

Orthologs for INO80C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for INO80C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INO80C 35
  • 100 (n)
  • 100 (a)
INO80C 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia INO80C 35
  • 90.62 (n)
  • 94.27 (a)
INO80C 36
  • 79 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 95 (a)
OneToMany
INO80C 35
  • 92.19 (n)
  • 95.31 (a)
mouse
(Mus musculus)
Mammalia Ino80c 35
  • 83.94 (n)
  • 84.82 (a)
Ino80c 16
Ino80c 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 81 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 77 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ino80c 35
  • 83.6 (n)
  • 85.34 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 76 (a)
OneToMany
INO80C 35
  • 70.29 (n)
  • 71.2 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 65 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9185 35
zebrafish
(Danio rerio)
Actinopterygii ino80c 35
  • 72.27 (n)
  • 79.83 (a)
ino80c 36
  • 55 (a)
OneToMany
wufj61b08 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008390 35
  • 58.97 (n)
  • 63.74 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12659 36
  • 45 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IES6 38
Species with no ortholog for INO80C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for INO80C Gene

ENSEMBL:
Gene Tree for INO80C (if available)
TreeFam:
Gene Tree for INO80C (if available)

Paralogs for INO80C Gene

Paralogs for INO80C Gene

genes like me logo Genes that share paralogs with INO80C: view

Variants for INO80C Gene

Sequence variations from dbSNP and Humsavar for INO80C Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs181423 -- 35,497,128(+) ACGGA(A/G)CCTAG intron-variant
rs189576 -- 35,497,696(+) CGCGC(A/G)GCCTG intron-variant, upstream-variant-2KB
rs191649 -- 35,498,082(+) CTGCC(A/G)CTCGG upstream-variant-2KB, utr-variant-5-prime
rs242064 -- 35,456,771(+) AAATA(C/T)AAACA intron-variant
rs242066 -- 35,488,980(+) caaca(A/G)ccacc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for INO80C Gene

Variant ID Type Subtype PubMed ID
nsv2252 CNV Loss 18451855

Relevant External Links for INO80C Gene

HapMap Linkage Disequilibrium report
INO80C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INO80C Gene

Disorders for INO80C Gene

Relevant External Links for INO80C

Genetic Association Database (GAD)
INO80C
genes like me logo Genes that share disorders with INO80C: view

No data available for UniProtKB/Swiss-Prot for INO80C Gene

Publications for INO80C Gene

  1. A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex. (PMID: 16230350) Jin J. … Conaway J.W. (J. Biol. Chem. 2005) 2 3 4
  2. Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PMID: 17370265) Denis N.J. … Figeys D. (Proteomics 2007) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. (PMID: 15960975) Dou Y. … Roeder R.G. (Cell 2005) 3 4

Products for INO80C Gene

Sources for INO80C Gene

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