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Aliases for INO80C Gene

Aliases for INO80C Gene

  • INO80 Complex Subunit C 2 3 5
  • IES6 Homolog 3 4
  • C18orf37 3 4
  • HIes6 3 4
  • Chromosome 18 Open Reading Frame 37 2
  • IES6 Homolog (S. Cerevisiae) 2
  • IES6 3

External Ids for INO80C Gene

Previous HGNC Symbols for INO80C Gene

  • C18orf37

Previous GeneCards Identifiers for INO80C Gene

  • GC18M031289
  • GC18M033034
  • GC18M029908

Summaries for INO80C Gene

GeneCards Summary for INO80C Gene

INO80C (INO80 Complex Subunit C) is a Protein Coding gene. Among its related pathways are Deubiquitination and Metabolism of proteins. An important paralog of this gene is ENSG00000267140.

UniProtKB/Swiss-Prot for INO80C Gene

  • Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INO80C Gene

Genomics for INO80C Gene

Regulatory Elements for INO80C Gene

Enhancers for INO80C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18G035455 1.9 FANTOM5 Ensembl ENCODE dbSUPER 18.3 +37.3 37295 9.7 HDGF FOXA2 ARNT ARID4B CBX5 FOS ZHX2 JUNB REST SMARCB1 ENSG00000268573 INO80C ENSG00000267583 LOC101927809 MAPRE2 LOC105372063
GH18G035495 1.4 ENCODE dbSUPER 8.3 +0.9 946 3.1 MLX CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 TBX21 ENSG00000268573 ZNF397 ELP2 ZSCAN30 ZNF271P ZNF396 C18orf21 INO80C ENSG00000267140 ENSG00000279074
GH18G035475 1.8 FANTOM5 Ensembl ENCODE dbSUPER 5.9 +18.5 18516 7.0 PKNOX1 FOXA2 ATF1 MLX ARID4B YY1 FOS NFYC MIER2 PPARG INO80C ZNF396 MAPRE2 ZNF24 ENSG00000279074 ENSG00000267583
GH18G035512 1.6 FANTOM5 Ensembl ENCODE dbSUPER 6.1 -16.5 -16547 4.4 TBP JUN MAX KLF17 RAD21 ZIC2 GLIS2 GATA3 ZNF316 SMC3 GALNT1 ZNF396 INO80C
GH18G035501 1.1 Ensembl ENCODE dbSUPER 8.7 -4.0 -4026 1.0 MAFG REST MIER2 ZNF644 ZNF316 MAFF ZSCAN29 EMSY MAFK SPI1 GALNT1 ZNF396 INO80C
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around INO80C on UCSC Golden Path with GeneCards custom track

Promoters for INO80C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000102223 291 1401 MLX CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 TBX21

Genomic Location for INO80C Gene

Chromosome:
18
Start:
35,452,230 bp from pter
End:
35,497,991 bp from pter
Size:
45,762 bases
Orientation:
Minus strand

Genomic View for INO80C Gene

Genes around INO80C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INO80C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INO80C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INO80C Gene

Proteins for INO80C Gene

  • Protein details for INO80C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PI98-IN80C_HUMAN
    Recommended name:
    INO80 complex subunit C
    Protein Accession:
    Q6PI98
    Secondary Accessions:
    • B4DUI4
    • E9PCS7
    • Q86WR1
    • Q8N994

    Protein attributes for INO80C Gene

    Size:
    192 amino acids
    Molecular mass:
    20643 Da
    Quaternary structure:
    • Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the helicase ATP-binding and the helicase C-terminal domain of INO80. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10.

    Alternative splice isoforms for INO80C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for INO80C Gene

Post-translational modifications for INO80C Gene

  • Ubiquitination at posLast=2121, isoforms=3, 422, and posLast=4141
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for INO80C Gene

Domains & Families for INO80C Gene

Gene Families for INO80C Gene

Protein Domains for INO80C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for INO80C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with INO80C: view

No data available for UniProtKB/Swiss-Prot for INO80C Gene

Function for INO80C Gene

Molecular function for INO80C Gene

UniProtKB/Swiss-Prot Function:
Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

Gene Ontology (GO) - Molecular Function for INO80C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with INO80C: view
genes like me logo Genes that share phenotypes with INO80C: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Cell Line Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for INO80C Gene

Localization for INO80C Gene

Subcellular locations from UniProtKB/Swiss-Prot for INO80C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for INO80C gene
Compartment Confidence
nucleus 5
mitochondrion 3

Gene Ontology (GO) - Cellular Components for INO80C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0031011 Ino80 complex IDA,IEA 21303910
GO:0071339 MLL1 complex IDA 15960975
genes like me logo Genes that share ontologies with INO80C: view

Pathways & Interactions for INO80C Gene

genes like me logo Genes that share pathways with INO80C: view

Gene Ontology (GO) - Biological Process for INO80C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006310 DNA recombination IEA --
GO:0006338 chromatin remodeling IBA,IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with INO80C: view

No data available for SIGNOR curated interactions for INO80C Gene

Drugs & Compounds for INO80C Gene

No Compound Related Data Available

Transcripts for INO80C Gene

Unigene Clusters for INO80C Gene

INO80 complex subunit C:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for INO80C Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b
SP1: - - - - -
SP2: - - - - - -
SP3: -
SP4: - - - - - - - - - - -
SP5: - - - - - - - -
SP6: - - -
SP7: - - - - - - -
SP8: - - - - -
SP9: - - - - - - - - - - - - - -
SP10: - - - - - - - - - - -
SP11: - -
SP12: - - - - - - - - - - - - -

Relevant External Links for INO80C Gene

GeneLoc Exon Structure for
INO80C
ECgene alternative splicing isoforms for
INO80C

Expression for INO80C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for INO80C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for INO80C Gene

This gene is overexpressed in Peripheral blood mononuclear cells (35.1), Blymphocyte (7.3), CD8 Tcells (7.0), and NK cells (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for INO80C Gene



Protein tissue co-expression partners for INO80C Gene

NURSA nuclear receptor signaling pathways regulating expression of INO80C Gene:

INO80C

SOURCE GeneReport for Unigene cluster for INO80C Gene:

Hs.464903

Evidence on tissue expression from TISSUES for INO80C Gene

  • Muscle(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with INO80C: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for INO80C Gene

Orthologs for INO80C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for INO80C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INO80C 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 95 (a)
OneToMany
INO80C 34
  • 92.19 (n)
cow
(Bos Taurus)
Mammalia INO80C 34 35
  • 90.62 (n)
mouse
(Mus musculus)
Mammalia Ino80c 34 16 35
  • 83.94 (n)
rat
(Rattus norvegicus)
Mammalia Ino80c 34
  • 83.6 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 81 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 77 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 76 (a)
OneToMany
INO80C 34
  • 70.29 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 65 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ino80c 34 35
  • 72.27 (n)
wufj61b08 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9185 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008390 34
  • 58.97 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG12659 35
  • 45 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IES6 37
Species where no ortholog for INO80C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for INO80C Gene

ENSEMBL:
Gene Tree for INO80C (if available)
TreeFam:
Gene Tree for INO80C (if available)

Paralogs for INO80C Gene

Paralogs for INO80C Gene

genes like me logo Genes that share paralogs with INO80C: view

Variants for INO80C Gene

Sequence variations from dbSNP and Humsavar for INO80C Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1000004294 -- 35,474,139(+) TTATG(C/T)GTTCA intron-variant
rs1000016143 -- 35,473,654(+) TGAAG(A/T)GCCAG intron-variant
rs1000028025 -- 35,498,787(+) ATTAA(A/G)TGTAT upstream-variant-2KB
rs1000098530 -- 35,473,710(+) TCAGG(C/G)AACAG intron-variant
rs1000257090 -- 35,498,513(+) CTCAG(C/G)CTCCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for INO80C Gene

Variant ID Type Subtype PubMed ID
nsv1065113 CNV loss 25217958
nsv2252 CNV deletion 18451855

Variation tolerance for INO80C Gene

Residual Variation Intolerance Score: 51.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.38; 42.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for INO80C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
INO80C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INO80C Gene

Disorders for INO80C Gene

Relevant External Links for INO80C

Genetic Association Database (GAD)
INO80C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
INO80C

No disorders were found for INO80C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for INO80C Gene

Publications for INO80C Gene

  1. A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex. (PMID: 16230350) Jin J. … Conaway J.W. (J. Biol. Chem. 2005) 2 3 4 64
  2. Subunit organization of the human INO80 chromatin remodeling complex: An evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. (PMID: 21303910) Chen L. … Conaway R.C. (J. Biol. Chem. 2011) 3 4 64
  3. Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. (PMID: 18922472) Yao T. … Conaway J.W. (Mol. Cell 2008) 3 4 64
  4. Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. (PMID: 15960975) Dou Y. … Roeder R.G. (Cell 2005) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for INO80C Gene

Sources for INO80C Gene

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