Free for academic non-profit institutions. Other users need a Commercial license

Aliases for INO80B Gene

Aliases for INO80B Gene

  • INO80 Complex Subunit B 2 3
  • High Mobility Group AT-Hook 1-Like 4 2 3 4
  • Zinc Finger HIT Domain-Containing Protein 4 3 4
  • PAP-1-Associated Protein 1 3 4
  • Zinc Finger, HIT Type 4 2 3
  • PAP-1 Binding Protein 2 3
  • IES2 Homolog 3 4
  • HMGA1L4 3 4
  • ZNHIT4 3 4
  • PAPA-1 3 4
  • HIes2 3 4
  • PAP (Pim-1 Associated Protein) Associated Protein 1 3
  • IES2 Homolog (S. Cerevisiae) 2
  • HMGIYL4 3
  • PAP-1BP 3
  • PAPA1 4
  • IES2 3

External Ids for INO80B Gene

Previous Symbols for INO80B Gene

  • HMGA1L4
  • ZNHIT4

Summaries for INO80B Gene

Entrez Gene Summary for INO80B Gene

  • This gene encodes a subunit of an ATP-dependent chromatin remodeling complex, INO80, which plays a role in DNA and nucleosome-activated ATPase activity and ATP-dependent nucleosome sliding. Readthrough transcription of this gene into the neighboring downstream gene, which encodes WW domain-binding protein 1, generates a non-coding transcript. [provided by RefSeq, Feb 2011]

GeneCards Summary for INO80B Gene

INO80B (INO80 Complex Subunit B) is a Protein Coding gene.

UniProtKB/Swiss-Prot for INO80B Gene

  • Induces growth and cell cycle arrests at the G1 phase of the cell cycle.

  • Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INO80B Gene

Genomics for INO80B Gene

Genomic Location for INO80B Gene

Start:
74,455,023 bp from pter
End:
74,457,960 bp from pter
Size:
2,938 bases
Orientation:
Plus strand

Genomic View for INO80B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for INO80B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INO80B Gene

Regulatory Elements for INO80B Gene

Proteins for INO80B Gene

  • Protein details for INO80B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C086-IN80B_HUMAN
    Recommended name:
    INO80 complex subunit B
    Protein Accession:
    Q9C086
    Secondary Accessions:

    Protein attributes for INO80B Gene

    Size:
    356 amino acids
    Molecular mass:
    38637 Da
    Quaternary structure:
    • Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the helicase ATP-binding and the helicase C-terminal domain of INO80. Interacts with RP9.
    SequenceCaution:
    • Sequence=BAB21111.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for INO80B Gene

Proteomics data for INO80B Gene at MOPED

Post-translational modifications for INO80B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for INO80B Gene

No data available for DME Specific Peptides for INO80B Gene

Domains for INO80B Gene

Gene Families for INO80B Gene

HGNC:
  • INO80 :INO80 complex subunits
  • ZNHIT :Zinc fingers, HIT-type

Protein Domains for INO80B Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

IN80B_HUMAN
Similarity:
  • Contains 1 HIT-type zinc finger.:
    • Q9C086
genes like me logo Genes that share domains with INO80B: view

Function for INO80B Gene

Molecular function for INO80B Gene

UniProtKB/Swiss-Prot Function: Induces growth and cell cycle arrests at the G1 phase of the cell cycle.
UniProtKB/Swiss-Prot Function: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

Gene Ontology (GO) - Molecular Function for INO80B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19095771
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with INO80B: view

miRNA for INO80B Gene

miRTarBase miRNAs that target INO80B

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for INO80B Gene

Localization for INO80B Gene

Subcellular locations from UniProtKB/Swiss-Prot for INO80B Gene

Nucleus. Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for INO80B Gene COMPARTMENTS Subcellular localization image for INO80B gene
Compartment Confidence
nucleus 5
plasma membrane 4
cytosol 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for INO80B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with INO80B: view

Pathways for INO80B Gene

SuperPathways for INO80B Gene

No Data Available

Gene Ontology (GO) - Biological Process for INO80B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006310 DNA recombination IEA --
GO:0006338 chromatin remodeling IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with INO80B: view

No data available for Pathways by source for INO80B Gene

Transcripts for INO80B Gene

Unigene Clusters for INO80B Gene

INO80 complex subunit B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for INO80B Gene

No ASD Table

Relevant External Links for INO80B Gene

GeneLoc Exon Structure for
INO80B
ECgene alternative splicing isoforms for
INO80B

Expression for INO80B Gene

mRNA expression in normal human tissues for INO80B Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for INO80B Gene

SOURCE GeneReport for Unigene cluster for INO80B Gene Hs.410786

genes like me logo Genes that share expressions with INO80B: view

Orthologs for INO80B Gene

This gene was present in the common ancestor of animals.

Orthologs for INO80B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INO80B 36
  • 99.34 (n)
  • 99.72 (a)
INO80B 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia INO80B 36
  • 89.33 (n)
  • 95.79 (a)
INO80B 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia INO80B 36
  • 89.33 (n)
  • 96.63 (a)
INO80B 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ino80b 36
  • 82.22 (n)
  • 90.67 (a)
Ino80b 16
Ino80b 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia INO80B 37
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia INO80B 37
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ino80b 36
  • 82.87 (n)
  • 90.45 (a)
lizard
(Anolis carolinensis)
Reptilia INO80B 37
  • 66 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5988 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100216277 36
  • 60.76 (n)
  • 61.35 (a)
Str.7311 36
zebrafish
(Danio rerio)
Actinopterygii ino80b 36
  • 63.78 (n)
  • 60.53 (a)
ino80b 37
  • 55 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10395 37
  • 26 (a)
OneToOne
Species with no ortholog for INO80B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for INO80B Gene

ENSEMBL:
Gene Tree for INO80B (if available)
TreeFam:
Gene Tree for INO80B (if available)

Paralogs for INO80B Gene

No data available for Paralogs for INO80B Gene

Variants for INO80B Gene

Sequence variations from dbSNP and Humsavar for INO80B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
VAR_055083 -

Structural Variations from Database of Genomic Variants (DGV) for INO80B Gene

Variant ID Type Subtype PubMed ID
dgv1199e1 CNV Complex 17122850
nsv458185 CNV Loss 19166990
nsv515851 CNV Loss 19592680
dgv4166n71 CNV Loss 21882294

Relevant External Links for INO80B Gene

HapMap Linkage Disequilibrium report
INO80B
Human Gene Mutation Database (HGMD)
INO80B

Disorders for INO80B Gene

No disorders were found for INO80B Gene.

No data available for UniProtKB/Swiss-Prot for INO80B Gene

Publications for INO80B Gene

  1. A novel nucleolar protein, PAPA-1, induces growth arrest as a result of cell cycle arrest at the G1 phase. (PMID: 15556297) Kuroda T.S. … Iguchi-Ariga S.M.M. (Gene 2004) 3 4 23
  2. A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex. (PMID: 16230350) Jin J. … Conaway J.W. (J. Biol. Chem. 2005) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. (PMID: 18922472) Yao T. … Conaway J.W. (Mol. Cell 2008) 3 4
  5. Subunit organization of the human INO80 chromatin remodeling complex: An evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. (PMID: 21303910) Chen L. … Conaway R.C. (J. Biol. Chem. 2011) 3 4

Products for INO80B Gene

Sources for INO80B Gene

Back to Top

Content