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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

INO80B Gene

protein-coding   GIFtS: 45
GCID: GC02P074682

INO80 complex subunit B

(Previous names: high mobility group AT-hook 1-like 4, zinc finger, HIT...)
(Previous symbols: HMGA1L4, ZNHIT4)
  Search for INO80B
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for INO80B    

Aliases
for INO80B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
INO80 Complex Subunit B1 2     PAP-1BP1 2
High Mobility Group AT-Hook 1-Like 41 2 3     Zinc Finger, HIT Type 41 2
HMGA1L41 2 3     Zinc Finger HIT Domain-Containing Protein 42 3
PAPA-11 2 3     IES2 Homolog2 3
ZNHIT41 2 3     PAP-1-Associated Protein 12 3
HIes21     PAP (Pim-1 Associated Protein) Associated Protein 12
HMGIYL41 2     PAP-1 Binding Protein2
IES21 2     PAPA13

External Ids:    HGNC: 133241   Entrez Gene: 834442   Ensembl: ENSG000001152747   UniProtKB: Q9C0863   
ORGUL members:         
NONCODE:n410586    

Export aliases for INO80B gene to outside databases

Previous GC identifers: GC02P074536 GC02P074419


Summaries
for INO80B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for INO80B:
This gene encodes a subunit of an ATP-dependent chromatin remodeling complex, INO80, which plays a role in DNA and
nucleosome-activated ATPase activity and ATP-dependent nucleosome sliding. Readthrough transcription of this gene into
the neighboring downstream gene, which encodes WW domain-binding protein 1, generates a non-coding transcript.
(provided by RefSeq, Feb 2011)

UniProtKB/Swiss-Prot: IN80B_HUMAN, Q9C086
Function: Induces growth and cell cycle arrests at the G1 phase of the cell cycle
Function: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional
regulation, DNA replication and probably DNA repair




Genomic Views
for INO80B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the INO80B gene promoter:
         HOXA9   ER-alpha   GR   p53   GCNF   E47   GCNF-1   Hand1   GR-alpha   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: INO80B promoter sequence
   Search SABiosciences Chromatin IP Primers for INO80B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INO80B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13.1   Ensembl cytogenetic band:  2p13.1   HGNC cytogenetic band: 2p13.1

INO80B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INO80B gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P074682:  view genomic region     (about GC identifiers)

Start:
 74,682,150 bp from pter      End:
 74,688,011 bp from pter
Size:
 5,862 bases      Orientation:
 plus strand

Proteins
for INO80B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IN80B_HUMAN, Q9C086 (See protein sequence)
Recommended Name: INO80 complex subunit B  
Size: 356 amino acids; 38637 Da
Subunit: Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the
helicase ATP-binding and the helicase C-terminal domain of INO80. Interacts with RP9
Subcellular location: Nucleus. Nucleus, nucleolus
Sequence caution: Sequence=BAB21111.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Explore the universe of human proteins at neXtProt for INO80B: NX_Q9C086

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9C086

    • INO80B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_112578.2  
    ENSEMBL proteins: 
     ENSP00000233331   ENSP00000389887   ENSP00000388677   ENSP00000392498   ENSP00000387267  
     ENSP00000386937   ENSP00000398740  

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    Uscn Proteins for INO80B

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IEA--
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA--
    GO:0031011Ino80 complex IDA--


    INO80B for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for INO80B

    Protein Domains /
    Families
    for INO80B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    INO80B for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR007529 Znf_HIT
     IPR006880 PAPA1

    Graphical View of Domain Structure for InterPro Entry Q9C086

    ProtoNet protein and cluster: Q9C086

    UniProtKB/Swiss-Prot: IN80B_HUMAN, Q9C086
    Similarity: Contains 1 HIT-type zinc finger


    Function
    for INO80B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: IN80B_HUMAN, Q9C086
    Function: Induces growth and cell cycle arrests at the G1 phase of the cell cycle
    Function: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional
    regulation, DNA replication and probably DNA repair

    miRNA
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    hsa-miR-633
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    Inhib. RNA
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    OriGene shRNA RFP: INO80B
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19095771
    GO:0046872metal ion binding IEA--


    INO80B for ontologies           About GeneDecksing



    Pathways & Interactions
    for INO80B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for INO80B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/22 Interacting proteins for INO80B (Q9C0861, 2, 3 ENSP000002333314) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UIMC1Q96RL12, 3, ENSP000003664344MINT-65401 I2D: score=4 STRING: ENSP00000366434
    IGFBP2P180651, 3, ENSP000002338094EBI-715611,EBI-2504392 I2D: score=1 STRING: ENSP00000233809
    CD81P600332, 3, ENSP000002636454MINT-65400 I2D: score=5 STRING: ENSP00000263645
    ACTR5Q9H9F93, ENSP000002439034I2D: score=2 STRING: ENSP00000243903
    ACTR8Q9H9813, ENSP000003368424I2D: score=2 STRING: ENSP00000336842
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair IEA--
    GO:0006310DNA recombination IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--


    INO80B for ontologies           About GeneDecksing



    Drugs & Compounds
    for INO80B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for INO80B
    Search CenterWatch for drugs/clinical trials and news about INO80B / IN80B 

    Transcripts
    for INO80B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for INO80B gene: 
    NM_031288.3  

    Unigene Cluster for INO80B:

    INO80 complex subunit B
    Hs.410786  [show with all ESTs]
    Unigene Representative Sequence: NR_037849
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000233331(uc002slg.3 uc010yrr.2 uc010yrs.2) ENST00000431187
    ENST00000452361(uc002sli.2) ENST00000494986 ENST00000441673 ENST00000409917
    ENST00000471577 ENST00000473618 ENST00000409493 ENST00000469849 ENST00000455562


    miRNA
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    hsa-miR-633
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    Inhib. RNA
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    OriGene shRNA RFP: INO80B
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AB054538.1 AK295889.1 AK295901.1 BC039617.1 BC050666.2 BC064425.1 NR_037849.1 

    11 DOTS entries:

    DT.310026  DT.100823654  DT.120976802  DT.92427515  DT.100818530  DT.101981488  DT.97855589  DT.100818531 
    DT.92427519  DT.86855554  DT.86855555 

    24/476 AceView cDNA sequences (see all 476):

    CD673701 CK430508 CR626166 BC050666 AI669449 AB054538 CB306223 AI871034 
    CN480311 BC071626 AW054812 BM805624 CD513481 CA418903 BM707932 BC064425 
    BM700467 CB853675 AA652370 AA308975 BU169524 BF223045 CA312871 BM672983 

    GeneLoc Exon Structure


    Expression
    for INO80B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    INO80B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCCGCTCTTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See INO80B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for INO80B

    SOURCE GeneReport for Unigene cluster: Hs.410786
        SABiosciences Expression via Pathway-Focused PCR Array including INO80B: 
              Polycomb & Trithorax Complexes in human mouse rat

    Primer
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    In Situ
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    Orthologs
    for INO80B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for INO80B gene from 8/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Ino80b1 , 5 INO80 complex subunit B1, 5 84.35(n)1
    94.46(a)1    		   6 (35.94 cM)5
    700201  NM_023547.11  NP_076036.11 
     831217655 
    chicken
    (Gallus gallus)    		 Aves INO80B6
    		 --
    		 69(a)
    		 1 ↔ 1
    		 Un(13899298-13900167)
    lizard
    (Anolis carolinensis)    		 Reptilia INO80B6
    		 --
    		 66(a)
    		 1 ↔ 1
    		 GL344203.1(42608-46807)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.59882 Xenopus laevis transcribed sequence with weak similarity more 77.67(n)    BQ736030.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1533471 zgc:153347 64.35(n)
    61.59(a)    		   768122  NM_001077258.1  NP_001070726.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG103951 CG10395 41.71(n)
    38.8(a)    		   35490  NM_136323.3  NP_610167.2 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G066606
    AT2G473506
    (see all 3)    		 PAPA-1-like and zinc finger-HIT domain-containing ...
    HIT zinc finger and PAPA-1-like domain-containing ...
    (see all 3)    		 15(a)
    12(a)
    (see all 3)    		 many → 1
    many → 1
    (see all 3)    		 3(2102402-2104906)
    2(19433791-19437249)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 PAPA-1-like conserved region family protein, expre...
    PAPA-1-like conserved region family protein, expre...
    		 11(a)
    11(a)
    		 many → 1
    many → 1
    		 3(33981086-33984964)
    12(22939381-22942802)


    ENSEMBL Gene Tree for INO80B (if available)
    TreeFam Gene Tree for INO80B (if available) 

    Paralogs
    for INO80B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for INO80B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/53 NCBI SNPs in INO80B are shown (see all 53)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1884412051,2
    		--74680254(+) CTACTC/TACTCT 2 -- us2k10--------
    rs1807996691,2
    		--74680307(+) TATTAC/TGCTGA 2 -- us2k10--------
    rs1865230071,2
    		--74680323(+) TCCCCA/TCTCAC 2 -- us2k10--------
    rs1907146211,2
    		--74680332(+) ACACTA/TTCATC 2 -- us2k10--------
    rs1819620791,2
    		--74680408(+) TTGGGC/TAAAAC 2 -- us2k10--------
    rs1869925681,2
    		--74680427(+) TCCCTG/TCTTAA 2 -- us2k10--------
    rs1382986201,2
    		--74680709(+) TTGCAC/TAGCTA 2 -- us2k10--------
    rs1413231321,2
    		--74680810(+) CCCCAA/GTATAA 2 -- us2k10--------
    rs1163850671,2
    		C,--74681101(+) TAATCC/TTGAAA 2 -- us2k10--------
    rs67466121,2
    		A--74681301(+) ttttgG/Tatttt 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for INO80B (74682150 - 74688011 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for INO80B
         3 CNVs: 50556 3366 50558

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for INO80B

    Disorders / Diseases
    for INO80B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for INO80B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for INO80B gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with INO80B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex. (PubMed id 16230350)1, 2, 3 Jin J.... Conaway J.W. (2005)
    2. A novel nucleolar protein, PAPA-1, induces growth arrest as a result of cell cycle arrest at the G1 phase. (PubMed id 15556297)1, 2, 9 Kuroda T.S....Iguchi-Ariga S.M.M. (2004)
    3. Subunit organization of the human INO80 chromatin remodeling complex: An evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. (PubMed id 21303910)1, 2 Chen L.... Conaway R.C. (2011)
    4. Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. (PubMed id 18922472)1, 2 Yao T....Conaway J.W. (2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    7. PAPA-1 Is a nuclear binding partner of IGFBP-2 and modulates its growth-promoting actions. (PubMed id 19095771)1 Miyako K....Cohen P. (2009)
    8. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    10. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)

    External Searches for INO80B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing INO80B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 83444 HGNC: 13324 AceView: WBP1andHMGA1L4 Ensembl:ENSG00000115274 euGenes: HUgn83444
    ECgene: INO80B H-InvDB: INO80B

    Other Databases showing INO80B gene

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    Specialized Databases showing INO80B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for INO80B Pharmacogenomics, SNPs, Pathways

    Intellectual Property
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    		Patent Information for INO80B gene:
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