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Aliases for INO80 Gene

Aliases for INO80 Gene

  • INO80 Complex Subunit 2 3 5
  • INO80 Complex Subunit A 2 3 4
  • Putative DNA Helicase INO80 Complex Homolog 1 3 4
  • INO80A 3 4
  • HINO80 3 4
  • INOC1 3 4
  • INO80 Complex Homolog 1 (S. Cerevisiae) 2
  • INO80 Homolog (S. Cerevisiae) 2
  • Homolog Of Yeast INO80 3
  • DNA Helicase INO80 3
  • INO80 Homolog 3
  • EC 3.6.1.23 61
  • EC 3.6.4.12 4
  • KIAA1259 4
  • EC 3.6.1 61

External Ids for INO80 Gene

Previous HGNC Symbols for INO80 Gene

  • INOC1

Previous GeneCards Identifiers for INO80 Gene

  • GC15M039058
  • GC15M041271
  • GC15M018119

Summaries for INO80 Gene

Entrez Gene Summary for INO80 Gene

  • This gene encodes a subunit of the chromatin remodeling complex, which is classified into subfamilies depending on sequence features apart from the conserved ATPase domain. This protein is the catalytic ATPase subunit of the INO80 chromatin remodeling complex, which is characterized by a DNA-binding domain. This protein is proposed to bind DNA and be recruited by the YY1 transcription factor to activate certain genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for INO80 Gene

INO80 (INO80 Complex Subunit) is a Protein Coding gene. Diseases associated with INO80 include Dentin Caries and Enamel Caries. Among its related pathways are Deubiquitination and Metabolism of proteins. GO annotations related to this gene include actin binding and DNA helicase activity. An important paralog of this gene is SMARCA4.

UniProtKB/Swiss-Prot for INO80 Gene

  • DNA helicase and probable main scaffold component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; according to PubMed:20687897 the contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Recruited by YY1 to YY1-activated genes, where it acts as an essential coactivator. Binds DNA. In vitro, has double-stranded DNA-dependent ATPase activity. Involved in UV-damage excision repair, DNA replication and chromosome segregation during normal cell division cycle.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INO80 Gene

Genomics for INO80 Gene

Regulatory Elements for INO80 Gene

Enhancers for INO80 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G040981 1 Ensembl ENCODE 6.7 +132.2 132161 4.9 CTCF JUN CEBPG FOSL1 GATA3 GATA2 FOS NFE2L2 SMARCE1 BHLHE40 CHAC1 DLL4 NDUFAF1 SPINT1 INO80 IVD GC15M040995 LOC105370789
GH15G040991 1.1 ENCODE 6 +123.9 123935 1.8 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 FOS KLF13 RPAP1 BAHD1 ENSG00000259211 RAD51-AS1 DNAJC17 NDUFAF1 INO80 GC15M040995 LOC105370789
GH15G041114 1.2 ENCODE 5.1 +0.2 235 2.9 CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 PPARGC1A DNAJC17 NDUFAF1 INO80 ENSG00000259617 CYCSP2
GH15G041016 1 Ensembl ENCODE 6 +98.0 98013 3.3 CTCF SIN3A RAD21 CTBP1 GATA3 POLR2A SCRT2 SMC3 FOS CREM ENSG00000251161 VPS18 DLL4 NDUFAF1 CHAC1 SPINT1 CHP1 EXD1 RTF1 INO80
GH15G041000 0.7 ENCODE 6 +114.7 114730 1.4 STAT1 FOXA2 MLX MAX RAD21 NR2F2 YY1 FOXA1 JUND BCL6B NDUFAF1 INO80 ENSG00000259617 ENSG00000259463
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around INO80 on UCSC Golden Path with GeneCards custom track

Promoters for INO80 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000075610 354 2001 CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 PPARGC1A

Genomic Location for INO80 Gene

Chromosome:
15
Start:
40,978,880 bp from pter
End:
41,116,354 bp from pter
Size:
137,475 bases
Orientation:
Minus strand

Genomic View for INO80 Gene

Genes around INO80 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INO80 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INO80 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INO80 Gene

Proteins for INO80 Gene

  • Protein details for INO80 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULG1-INO80_HUMAN
    Recommended name:
    DNA helicase INO80
    Protein Accession:
    Q9ULG1
    Secondary Accessions:
    • A6H8X4
    • Q9NTG6

    Protein attributes for INO80 Gene

    Size:
    1556 amino acids
    Molecular mass:
    176753 Da
    Quaternary structure:
    • Component of the chromatin-remodeling INO80 complex; three different complex modules assemble on different domains of INO80. Interacts with DDB1.
    SequenceCaution:
    • Sequence=BAA86573.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for INO80 Gene

Selected DME Specific Peptides for INO80 Gene

Q9ULG1:
  • IDIGGGV
  • LKPFMLRR
  • NLTAADTVIF
  • DEMGLGKT
  • ADTVIFY
  • NRLLLTGTP
  • ISGGNFKPD
  • KVLPYWG
  • RKVCNHP
  • KDIESHA
  • NWLANLY
  • ITSYQLV
  • GTIEERI
  • CRNRLLL
  • FYDSDWNP
  • FLLSTRA
  • QAMDRAHR
  • AGGLGINL
  • NGILADE
  • QVTVYRL
  • GLGKTVQ
  • LLHFIMP
  • LSTRAGGLG

Post-translational modifications for INO80 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for INO80 Gene

Gene Families for INO80 Gene

Protein Domains for INO80 Gene

Suggested Antigen Peptide Sequences for INO80 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9ULG1

UniProtKB/Swiss-Prot:

INO80_HUMAN :
  • The DBINO region is involved in binding to DNA.
  • Belongs to the SNF2/RAD54 helicase family.
Domain:
  • The DBINO region is involved in binding to DNA.
Family:
  • Belongs to the SNF2/RAD54 helicase family.
genes like me logo Genes that share domains with INO80: view

Function for INO80 Gene

Molecular function for INO80 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
DNA helicase and probable main scaffold component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; according to PubMed:20687897 the contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Recruited by YY1 to YY1-activated genes, where it acts as an essential coactivator. Binds DNA. In vitro, has double-stranded DNA-dependent ATPase activity. Involved in UV-damage excision repair, DNA replication and chromosome segregation during normal cell division cycle.

Enzyme Numbers (IUBMB) for INO80 Gene

Gene Ontology (GO) - Molecular Function for INO80 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003677 DNA binding IDA 16298340
GO:0003678 DNA helicase activity IDA 16298340
GO:0003779 actin binding IEA --
GO:0004386 helicase activity IEA --
genes like me logo Genes that share ontologies with INO80: view
genes like me logo Genes that share phenotypes with INO80: view

Animal Models for INO80 Gene

MGI Knock Outs for INO80:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for INO80

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for INO80 Gene

Localization for INO80 Gene

Subcellular locations from UniProtKB/Swiss-Prot for INO80 Gene

Nucleus. Note=Colocalizes with PCNA at replication forks during S-phase. Recruited to DNA damage sites in a ACTR8-dependent manner.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for INO80 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
nucleus 5
mitochondrion 2
endoplasmic reticulum 2
cytosol 2

Gene Ontology (GO) - Cellular Components for INO80 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 16298340
GO:0005654 nucleoplasm TAS --
GO:0005874 microtubule IEA --
GO:0005886 plasma membrane IDA --
GO:0016604 nuclear body IDA --
genes like me logo Genes that share ontologies with INO80: view

Pathways & Interactions for INO80 Gene

genes like me logo Genes that share pathways with INO80: view

Gene Ontology (GO) - Biological Process for INO80 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000070 mitotic sister chromatid segregation IMP 20237820
GO:0000724 double-strand break repair via homologous recombination IMP 18026119
GO:0006281 DNA repair IEA --
GO:0006302 double-strand break repair IMP 20687897
GO:0006310 DNA recombination IEA --
genes like me logo Genes that share ontologies with INO80: view

No data available for SIGNOR curated interactions for INO80 Gene

Drugs & Compounds for INO80 Gene

(3) Drugs for INO80 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for INO80 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with INO80: view

Transcripts for INO80 Gene

Unigene Clusters for INO80 Gene

INO80 homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for INO80

Alternative Splicing Database (ASD) splice patterns (SP) for INO80 Gene

No ASD Table

Relevant External Links for INO80 Gene

GeneLoc Exon Structure for
INO80
ECgene alternative splicing isoforms for
INO80

Expression for INO80 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for INO80 Gene

Protein differential expression in normal tissues from HIPED for INO80 Gene

This gene is overexpressed in Esophagus (26.1), Monocytes (10.1), Peripheral blood mononuclear cells (8.4), and Adrenal (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for INO80 Gene



Protein tissue co-expression partners for INO80 Gene

NURSA nuclear receptor signaling pathways regulating expression of INO80 Gene:

INO80

SOURCE GeneReport for Unigene cluster for INO80 Gene:

Hs.292949

mRNA Expression by UniProt/SwissProt for INO80 Gene:

Q9ULG1-INO80_HUMAN
Tissue specificity: According to PubMed:10574462, widely expressed. According to PubMed:16298340, specifically expressed in brain, liver and pancreas.

Evidence on tissue expression from TISSUES for INO80 Gene

  • Nervous system(4.6)
  • Muscle(2.6)
  • Kidney(2.4)
  • Heart(2.2)
genes like me logo Genes that share expression patterns with INO80: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for INO80 Gene

Orthologs for INO80 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for INO80 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INO80 34 35
  • 99.74 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia INO80 35
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia INO80 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia INO80 34 35
  • 93.93 (n)
cow
(Bos Taurus)
Mammalia INO80 34 35
  • 93.19 (n)
rat
(Rattus norvegicus)
Mammalia Ino80 34
  • 91.02 (n)
mouse
(Mus musculus)
Mammalia Ino80 34 16 35
  • 90.79 (n)
chicken
(Gallus gallus)
Aves INO80 34 35
  • 80.71 (n)
lizard
(Anolis carolinensis)
Reptilia INO80 35
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ino80 34
  • 73.58 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9075 34
zebrafish
(Danio rerio)
Actinopterygii ino80 34 35
  • 69.94 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ino80 34 35
  • 55.51 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005035 34
  • 54.81 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes INO80 35
  • 33 (a)
OneToOne
wheat
(Triticum aestivum)
Liliopsida Ta.4945 34
Species where no ortholog for INO80 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • worm (Caenorhabditis elegans)

Evolution for INO80 Gene

ENSEMBL:
Gene Tree for INO80 (if available)
TreeFam:
Gene Tree for INO80 (if available)

Paralogs for INO80 Gene

Paralogs for INO80 Gene

(3) SIMAP similar genes for INO80 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with INO80: view

Variants for INO80 Gene

Sequence variations from dbSNP and Humsavar for INO80 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs199722402 Likely pathogenic 40,987,186(+) CCATC(C/T)GCTGA nc-transcript-variant, reference, missense
rs730882226 Likely pathogenic 41,071,953(-) ACCCA(C/T)CTATC nc-transcript-variant, reference, missense
rs773955198 Uncertain significance 41,096,214(+) AAAAT(A/G)GTCCA nc-transcript-variant, reference, missense
rs1000029929 -- 41,094,891(+) TACAA(A/G)ACAGA intron-variant
rs1000068856 -- 41,025,647(+) GAGGC(A/G)AAGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for INO80 Gene

Variant ID Type Subtype PubMed ID
dgv4499n54 CNV loss 21841781
esv2496899 CNV insertion 19546169
nsv1053462 CNV gain 25217958
nsv1116068 CNV deletion 24896259
nsv1122952 CNV deletion 24896259
nsv474933 CNV novel sequence insertion 20440878
nsv976923 CNV duplication 23825009

Variation tolerance for INO80 Gene

Residual Variation Intolerance Score: 2.11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.86; 48.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for INO80 Gene

Human Gene Mutation Database (HGMD)
INO80
SNPedia medical, phenotypic, and genealogical associations of SNPs for
INO80

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INO80 Gene

Disorders for INO80 Gene

MalaCards: The human disease database

(3) MalaCards diseases for INO80 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
dentin caries
  • compound dental caries
enamel caries
  • dental caries limited to enamel
occlusion precerebral artery
  • occlusion and stenosis of multiple and bilateral precerebral arteries
- elite association - COSMIC cancer census association via MalaCards
Search INO80 in MalaCards View complete list of genes associated with diseases

Relevant External Links for INO80

Genetic Association Database (GAD)
INO80
Human Genome Epidemiology (HuGE) Navigator
INO80
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
INO80
genes like me logo Genes that share disorders with INO80: view

No data available for UniProtKB/Swiss-Prot and Genatlas for INO80 Gene

Publications for INO80 Gene

  1. Roles of human INO80 chromatin remodeling enzyme in DNA replication and chromosome segregation suppress genome instability. (PMID: 20237820) Hur S.K. … Kwon J. (Cell. Mol. Life Sci. 2010) 2 3 4 64
  2. Characterization of a human SWI2/SNF2 like protein hINO80: demonstration of catalytic and DNA binding activity. (PMID: 16298340) Bakshi R. … Brahmachari V. (Biochem. Biophys. Res. Commun. 2006) 2 3 4 64
  3. A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex. (PMID: 16230350) Jin J. … Conaway J.W. (J. Biol. Chem. 2005) 2 3 4 64
  4. Subunit organization of the human INO80 chromatin remodeling complex: An evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. (PMID: 21303910) Chen L. … Conaway R.C. (J. Biol. Chem. 2011) 3 4 64
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64

Products for INO80 Gene

  • Addgene plasmids for INO80

Sources for INO80 Gene

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