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Aliases for INO80 Gene

Aliases for INO80 Gene

  • INO80 Complex Subunit 2 3
  • INO80 Complex Subunit A 2 3 4
  • Putative DNA Helicase INO80 Complex Homolog 1 3 4
  • INO80A 3 4
  • HINO80 3 4
  • INOC1 3 4
  • INO80 Complex Homolog 1 (S. Cerevisiae) 2
  • INO80 Homolog (S. Cerevisiae) 2
  • Homolog Of Yeast INO80 3
  • DNA Helicase INO80 3
  • INO80 Homolog 3
  • EC 3.6.1.23 63
  • EC 3.6.4.12 4
  • KIAA1259 4
  • EC 3.6.1 63
  • INOC1, 6

External Ids for INO80 Gene

Previous HGNC Symbols for INO80 Gene

  • INOC1

Previous GeneCards Identifiers for INO80 Gene

  • GC15M039058
  • GC15M041271
  • GC15M018119

Summaries for INO80 Gene

Entrez Gene Summary for INO80 Gene

  • This gene encodes a subunit of the chromatin remodeling complex, which is classified into subfamilies depending on sequence features apart from the conserved ATPase domain. This protein is the catalytic ATPase subunit of the INO80 chromatin remodeling complex, which is characterized by a DNA-binding domain. This protein is proposed to bind DNA and be recruited by the YY1 transcription factor to activate certain genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for INO80 Gene

INO80 (INO80 Complex Subunit) is a Protein Coding gene. GO annotations related to this gene include actin binding and alpha-tubulin binding.

UniProtKB/Swiss-Prot for INO80 Gene

  • DNA helicase and probable main scaffold component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; according to PubMed:20687897 the contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Recruited by YY1 to YY1-activated genes, where it acts as an essential coactivator. Binds DNA. In vitro, has double-stranded DNA-dependent ATPase activity. Involved in UV-damage excision repair, DNA replication and chromosome segregation during normal cell division cycle.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INO80 Gene

Genomics for INO80 Gene

Regulatory Elements for INO80 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for INO80 Gene

Start:
40,978,880 bp from pter
End:
41,116,354 bp from pter
Size:
137,475 bases
Orientation:
Minus strand

Genomic View for INO80 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for INO80 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INO80 Gene

Proteins for INO80 Gene

  • Protein details for INO80 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULG1-INO80_HUMAN
    Recommended name:
    DNA helicase INO80
    Protein Accession:
    Q9ULG1
    Secondary Accessions:
    • A6H8X4
    • Q9NTG6

    Protein attributes for INO80 Gene

    Size:
    1556 amino acids
    Molecular mass:
    176753 Da
    Quaternary structure:
    • Component of the chromatin-remodeling INO80 complex; three different complex modules assemble on different domains of INO80. Interacts with DDB1.
    SequenceCaution:
    • Sequence=BAA86573.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for INO80 Gene

Proteomics data for INO80 Gene at MOPED

Post-translational modifications for INO80 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for INO80 Gene

Domains for INO80 Gene

Gene Families for INO80 Gene

HGNC:
  • INO80 :INO80 complex subunits

Protein Domains for INO80 Gene

Suggested Antigen Peptide Sequences for INO80 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9ULG1

UniProtKB/Swiss-Prot:

INO80_HUMAN :
  • Q9ULG1
Domain:
  • The DBINO region is involved in binding to DNA
  • Contains 1 DBINO domain.
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the SNF2/RAD54 helicase family.
genes like me logo Genes that share domains with INO80: view

Function for INO80 Gene

Molecular function for INO80 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function:
DNA helicase and probable main scaffold component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; according to PubMed:20687897 the contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Recruited by YY1 to YY1-activated genes, where it acts as an essential coactivator. Binds DNA. In vitro, has double-stranded DNA-dependent ATPase activity. Involved in UV-damage excision repair, DNA replication and chromosome segregation during normal cell division cycle.

Enzyme Numbers (IUBMB) for INO80 Gene

Gene Ontology (GO) - Molecular Function for INO80 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA 16298340
GO:0003678 DNA helicase activity IDA 16298340
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 18026119
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with INO80: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for INO80

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for INO80 Gene

Localization for INO80 Gene

Subcellular locations from UniProtKB/Swiss-Prot for INO80 Gene

Nucleus. Note=Colocalizes with PCNA at replication forks during S-phase. Recruited to DNA damage sites in a ACTR8-dependent manner.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for INO80 Gene COMPARTMENTS Subcellular localization image for INO80 gene
Compartment Confidence
nucleus 5
cytoskeleton 3
cytosol 2

Gene Ontology (GO) - Cellular Components for INO80 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005874 microtubule IEA --
GO:0031011 Ino80 complex IDA 18026119
genes like me logo Genes that share ontologies with INO80: view

Pathways for INO80 Gene

SuperPathways for INO80 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Polycomb & Trithorax Complexes in human,mouse,rat
    • Epigenetic Chromatin Remodeling Factors in human,mouse,rat

Gene Ontology (GO) - Biological Process for INO80 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000070 mitotic sister chromatid segregation IMP 20237820
GO:0000724 double-strand break repair via homologous recombination IMP 18026119
GO:0006200 obsolete ATP catabolic process --
GO:0006302 double-strand break repair IMP 20687897
GO:0006338 chromatin remodeling IDA 16298340
genes like me logo Genes that share ontologies with INO80: view

No data available for Pathways by source for INO80 Gene

Transcripts for INO80 Gene

Unigene Clusters for INO80 Gene

INO80 homolog (S. cerevisiae):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for INO80

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for INO80 Gene

No ASD Table

Relevant External Links for INO80 Gene

GeneLoc Exon Structure for
INO80
ECgene alternative splicing isoforms for
INO80

Expression for INO80 Gene

mRNA expression in normal human tissues for INO80 Gene

Protein differential expression in normal tissues for INO80 Gene

This gene is overexpressed in Esophagus (26.1), Monocytes (10.1), Peripheral blood mononuclear cells (8.4), and Adrenal (7.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for INO80 Gene

SOURCE GeneReport for Unigene cluster for INO80 Gene Hs.292949

mRNA Expression by UniProt/SwissProt for INO80 Gene

Q9ULG1-INO80_HUMAN
Tissue specificity: According to PubMed:10574462, widely expressed. According to PubMed:16298340, specifically expressed in brain, liver and pancreas.
genes like me logo Genes that share expressions with INO80: view

Expression partners for INO80 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for INO80 Gene

Orthologs for INO80 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for INO80 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia INO80 35
  • 93.19 (n)
  • 97.43 (a)
INO80 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia INO80 35
  • 93.93 (n)
  • 98.14 (a)
INO80 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ino80 35
  • 90.79 (n)
  • 97.04 (a)
Ino80 16
Ino80 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia INO80 35
  • 99.74 (n)
  • 99.94 (a)
INO80 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ino80 35
  • 91.02 (n)
  • 97.17 (a)
oppossum
(Monodelphis domestica)
Mammalia INO80 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia INO80 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves INO80 35
  • 80.71 (n)
  • 90.87 (a)
INO80 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia INO80 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ino80 35
  • 73.58 (n)
  • 81.02 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9075 35
zebrafish
(Danio rerio)
Actinopterygii ino80 35
  • 69.94 (n)
  • 77.06 (a)
ino80 36
  • 75 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005035 35
  • 54.81 (n)
  • 59.35 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ino80 35
  • 55.51 (n)
  • 55.86 (a)
Ino80 36
  • 43 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes INO80 36
  • 33 (a)
OneToOne
wheat
(Triticum aestivum)
Liliopsida Ta.4945 35
Species with no ortholog for INO80:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • worm (Caenorhabditis elegans)

Evolution for INO80 Gene

ENSEMBL:
Gene Tree for INO80 (if available)
TreeFam:
Gene Tree for INO80 (if available)

Paralogs for INO80 Gene

Selected SIMAP similar genes for INO80 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with INO80: view

No data available for Paralogs for INO80 Gene

Variants for INO80 Gene

Sequence variations from dbSNP and Humsavar for INO80 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs9796 -- 40,979,249(-) TTGCA(A/T)GGGAG utr-variant-3-prime, nc-transcript-variant
rs474351 -- 41,096,773(-) TGAAG(A/G)TGATG intron-variant
rs476633 -- 41,099,936(-) GAGTA(C/G)TTTTA intron-variant
rs480549 -- 41,114,744(-) tagca(C/G)gtatc intron-variant
rs485267 -- 41,114,224(-) AGTGG(C/T)GTGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for INO80 Gene

Variant ID Type Subtype PubMed ID
nsv904101 CNV Loss 21882294
dgv2360n71 CNV Loss 21882294
esv2496899 CNV Insertion 19546169
dgv2361n71 CNV Loss 21882294

Relevant External Links for INO80 Gene

HapMap Linkage Disequilibrium report
INO80
Human Gene Mutation Database (HGMD)
INO80

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INO80 Gene

Disorders for INO80 Gene

Relevant External Links for INO80

Genetic Association Database (GAD)
INO80
Human Genome Epidemiology (HuGE) Navigator
INO80

No disorders were found for INO80 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for INO80 Gene

Publications for INO80 Gene

  1. A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex. (PMID: 16230350) Jin J. … Conaway J.W. (J. Biol. Chem. 2005) 2 3 4
  2. Characterization of a human SWI2/SNF2 like protein hINO80: demonstration of catalytic and DNA binding activity. (PMID: 16298340) Bakshi R. … Brahmachari V. (Biochem. Biophys. Res. Commun. 2006) 2 3 4
  3. Roles of human INO80 chromatin remodeling enzyme in DNA replication and chromosome segregation suppress genome instability. (PMID: 20237820) Hur S.K. … Kwon J. (Cell. Mol. Life Sci. 2010) 2 3 4
  4. Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. (PMID: 18922472) Yao T. … Conaway J.W. (Mol. Cell 2008) 3 4
  5. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 3 4

Products for INO80 Gene

Sources for INO80 Gene

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