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INO80 Gene

protein-coding   GIFtS: 50
GCID: GC15M041271

INO80 Complex Subunit

(Previous names: INO80 complex homolog 1 (S. cerevisiae), INO80 homolog (S....)
(Previous symbol: INOC1)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
INO80 Complex Subunit1 2     DNA Helicase INO802
INOC11 2 3 5     Homolog Of Yeast INO802
INO80 Complex Subunit A1 2 3     INO80 Homolog2
Putative DNA Helicase INO80 Complex Homolog 12 3     EC 3.6.4.123
INO80A2 3     KIAA12593
hINO802 3     EC 3.6.18
INO80 Complex Homolog 1 (S. Cerevisiae)1     EC 3.6.1.238
INO80 Homolog (S. Cerevisiae)1     

External Ids:    HGNC: 269561   Entrez Gene: 546172   Ensembl: ENSG000001289087   OMIM: 6101695   UniProtKB: Q9ULG13   

Export aliases for INO80 gene to outside databases

Previous GC identifers: GC15M039058 GC15M018119


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for INO80 Gene:
This gene encodes a subunit of the chromatin remodeling complex, which is classified into subfamilies depending on
sequence features apart from the conserved ATPase domain. This protein is the catalytic ATPase subunit of the
INO80 chromatin remodeling complex, which is characterized by a DNA-binding domain. This protein is proposed to
bind DNA and be recruited by the YY1 transcription factor to activate certain genes. Alternative splicing results
in multiple transcript variants. (provided by RefSeq, Aug 2013)

GeneCards Summary for INO80 Gene:
INO80 (INO80 complex subunit) is a protein-coding gene. Diseases associated with INO80 include malaria. GO annotations related to this gene include actin binding and alpha-tubulin binding.

UniProtKB/Swiss-Prot: INO80_HUMAN, Q9ULG1
Function: DNA helicase and probable main scaffold component of the chromatin remodeling INO80 complex which is
involved in transcriptional regulation, DNA replication and probably DNA repair; according to PubMed:20687897 the
contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation.
Recruited by YY1 to YY1-activated genes, where it acts as an essential coactivator. Binds DNA. In vitro, has
double-stranded DNA-dependent ATPase activity. Involved in UV-damage excision repair, DNA replication and
chromosome segregation during normal cell division cycle




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the INO80 gene promoter:
         CREB   N-Myc   AREB6   TBP   Nkx6-1   RelA   NF-kappaB1   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidINO80 promoter sequence
   Search Chromatin IP Primers for INO80

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat INO80


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15.1   Ensembl cytogenetic band:  15q15.1   HGNC cytogenetic band: 15q15.1

INO80 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INO80 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M041271:  view genomic region     (about GC identifiers)

Start:
41,271,078 bp from pter      End:
41,408,552 bp from pter
Size:
137,475 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: INO80_HUMAN, Q9ULG1 (See protein sequence)
Recommended Name: DNA helicase INO80  
Size: 1556 amino acids; 176753 Da
Subunit: Component of the chromatin-remodeling INO80 complex; three different complex modules assemble on
different domains of INO80. Interacts with DDB1
Sequence caution: Sequence=BAA86573.1; Type=Erroneous initiation;
Secondary accessions: A6H8X4 Q9NTG6

Explore the universe of human proteins at neXtProt for INO80: NX_Q9ULG1

Explore proteomics data for INO80 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for INO80 (Q9ULG1) (see all 23)
     KDIESHA  IDIGGGV  NWLANLY  QVTVYRL 


    See INO80 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060023.1  
    ENSEMBL proteins: 
     ENSP00000355205   ENSP00000453677   ENSP00000452806   ENSP00000454057   ENSP00000384686  

    INO80 Human Recombinant Protein Products:

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    OriGene Custom Protein Services for INO80
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for INO80

    INO80 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Browse OriGene Antibodies
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    Novus Biologicals INO80 Antibodies
    Abcam antibodies for INO80
    Cloud-Clone Corp. Antibodies for INO80
    Search ThermoFisher Antibodies for INO80
    LSBio Antibodies in human, mouse, rat for INO80

    INO80 Assay Products:

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    Cloud-Clone Corp. ELISAs for INO80
    Cloud-Clone Corp. CLIAs for INO80


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    INO80: INO80 complex subunits

    5 InterPro protein domains:
     IPR000330 SNF2_N
     IPR020838 DBINO
     IPR027417 P-loop_NTPase
     IPR014001 Helicase_ATP-bd
     IPR001650 Helicase_C

    Graphical View of Domain Structure for InterPro Entry Q9ULG1

    ProtoNet protein and cluster: Q9ULG1

    1 Blocks protein domain: IPB000330 SNF2 related domain

    UniProtKB/Swiss-Prot: INO80_HUMAN, Q9ULG1
    Domain: The DBINO region is involved in binding to DNA
    Similarity: Belongs to the SNF2/RAD54 helicase family
    Similarity: Contains 1 DBINO domain
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    INO80 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: INO80_HUMAN, Q9ULG1
    Function: DNA helicase and probable main scaffold component of the chromatin remodeling INO80 complex which is
    involved in transcriptional regulation, DNA replication and probably DNA repair; according to PubMed:20687897 the
    contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation.
    Recruited by YY1 to YY1-activated genes, where it acts as an essential coactivator. Binds DNA. In vitro, has
    double-stranded DNA-dependent ATPase activity. Involved in UV-damage excision repair, DNA replication and
    chromosome segregation during normal cell division cycle
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.1.232 EC 3.6.4.121

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IDA16298340
    GO:0003678DNA helicase activity IDA16298340
    GO:0003779actin binding IEA--
    GO:0004386helicase activity ----
         
    INO80 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Ino80 (no phenotypes)

    INO80 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for INO80
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for INO80

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for INO80
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for INO80

    miRNA
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    Block miRNA regulation of human, mouse, rat INO80 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate INO80 (see all 74):
    hsa-miR-576-3p hsa-miR-3938 hsa-miR-642a hsa-miR-520e hsa-miR-106a hsa-miR-93 hsa-miR-3613-3p hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidINO80 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for INO80
    Predesigned siRNA for gene silencing in human, mouse, rat INO80

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for INO80

    Clone
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    OriGene clones in human, mouse for INO80 (see all 7)
    OriGene ORF clones in mouse, rat for INO80
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: INO80 (NM_017553)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INO80
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INO80

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for INO80 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INO80


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    INO80_HUMAN, Q9ULG1: Nucleus. Note=Colocalizes with PCNA at replication forks during S-phase. Recruited to DNA
    damage sites in a ACTR8-dependent manner
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton3
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005874microtubule IEA--
    GO:0031011Ino80 complex IDA18026119

    INO80 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Arrays including INO80: 
              Polycomb & Trithorax Complexes in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for INO80

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for INO80 (Q9ULG11, 3 ENSP000003552054) via UniProtKB, MINT, STRING, and/or I2D (see all 266)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4LP628053, ENSP000003482584I2D: score=3 STRING: ENSP00000348258
    HIST1H4FP628053, ENSP000003669744I2D: score=3 STRING: ENSP00000366974
    HIST1H4HP628053, ENSP000002893524I2D: score=3 STRING: ENSP00000289352
    HIST1H4AP628053I2D: score=3 
    HIST1H4BP628053I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000070mitotic sister chromatid segregation IMP--
    GO:0000724double-strand break repair via homologous recombination IMP18026119
    GO:0006200ATP catabolic process IDA16298340
    GO:0006302double-strand break repair IMP--
    GO:0006338chromatin remodeling IDA16298340

    INO80 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for INO80



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for INO80 gene (2 alternative transcripts): 
    NM_017553.2  NM_032196.3  

    Unigene Cluster for INO80:

    INO80 homolog (S. cerevisiae)
    Hs.292949  [show with all ESTs]
    Unigene Representative Sequence: NM_017553
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361937(uc021sjj.1 uc001zni.3 uc010ucu.2) ENST00000558357
    ENST00000558270 ENST00000560689 ENST00000560799 ENST00000561244 ENST00000557849
    ENST00000559995 ENST00000561172 ENST00000401393
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat INO80 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate INO80 (see all 74):
    hsa-miR-576-3p hsa-miR-3938 hsa-miR-642a hsa-miR-520e hsa-miR-106a hsa-miR-93 hsa-miR-3613-3p hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidINO80 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for INO80
    Predesigned siRNA for gene silencing in human, mouse, rat INO80
    Clone
    Products:
         
    OriGene clones in human, mouse for INO80 (see all 7)
    OriGene ORF clones in mouse, rat for INO80
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: INO80 (NM_017553)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INO80
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INO80
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for INO80
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat INO80
      QuantiTect SYBR Green Assays in human, mouse, rat INO80
      QuantiFast Probe-based Assays in human, mouse, rat INO80

    Additional mRNA sequence: 

    AB033085.1 AK002176.1 AK024777.1 AK026050.1 AK057582.1 AK290371.1 AL137280.1 BC012578.1 
    BC046115.2 BC057299.1 BC068054.1 BC105993.1 BC144681.1 BC146785.1 

    8 DOTS entries:

    DT.453868  DT.100021271  DT.95275721  DT.101961365  DT.75128153  DT.100659847  DT.405913  DT.40273088 

    Selected AceView cDNA sequences (see all 139):

    BF340537 AW802721 AI560090 BC046115 BQ016456 BE382857 AA505914 CB155560 
    BX479072 BX504669 BC012578 AA815104 BE935906 CB162390 BQ430950 NM_017553 
    BM766476 NM_032196 BQ225120 BQ440856 AA374274 AW589411 AB033085 N57454 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    INO80 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGGTGTTT
    INO80 Expression
    About this image

    INO80 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    INO80 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.292949

    UniProtKB/Swiss-Prot: INO80_HUMAN, Q9ULG1
    Tissue specificity: According to PubMed:10574462, widely expressed. According to PubMed:16298340, specifically
    expressed in brain, liver and pancreas

        Pathway & Disease-focused RT2 Profiler PCR Arrays including INO80: 
              Polycomb & Trithorax Complexes in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for INO80
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat INO80
    QuantiTect SYBR Green Assays in human, mouse, rat INO80
    QuantiFast Probe-based Assays in human, mouse, rat INO80
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INO80

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for INO80 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ino801 , 5 INO80 homolog (S. cerevisiae)1, 5 90.79(n)1
    97.04(a)1
      2 (59.97 cM)5
    681421  NM_026574.31  NP_080850.21 
     1193730425 
    chicken
    (Gallus gallus)
    Aves INO801 INO80 homolog (S. cerevisiae) 80.71(n)
    90.87(a)
      423210  NM_001199657.1  NP_001186586.1 
    lizard
    (Anolis carolinensis)
    Reptilia INO806
    INO80 complex subunit
    89(a)
    1 ↔ 1
    1(41836540-41890581)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.90752 Xenopus laevis transcribed sequence with moderate similarity more 79.03(n)    BJ041350.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ino801 INO80 homolog (S. cerevisiae) 69.94(n)
    77.06(a)
      566768  NM_001045119.1  NP_001038584.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ino801 Ino80 55.51(n)
    55.86(a)
      42314  NM_169854.1  NP_732413.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes INO806
    ATPase and nucleosome spacing factor, subunit of c...
    33(a)
    1 ↔ 1
    VII(221104-225573) YGL150C
    wheat
    (Triticum aestivum)
    Liliopsida Ta.49452 Triticum aestivum transcribed sequence with weak similarity more 72.9(n)    BQ245393.1 


    ENSEMBL Gene Tree for INO80 (if available)
    TreeFam Gene Tree for INO80 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for INO80 gene
    3 SIMAP similar genes for INO80 using alignment to 4 protein entries:     INO80_HUMAN (see all proteins):
    DKFZp686N224    SMARCA5    HELLS

    INO80 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for INO80 (see all 2956)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1496008371,2
    Cuntested121385201(+) GCAGCG/AACGCA 2 /R /C mis11Minor allele frequency- A:0.00EU 1323
    rs602705931,2
    C--18138721(+) TTTTT-/T/TT  
            
    AGACG
    1 -- int11NA 2
    rs31014391,2
    C--18164495(+) AAAAAA/CAAAAC 1 -- int13Minor allele frequency- C:0.00NA WA CSA 5
    rs1997702041,2
    C--18186644(-) TTTTTC/TCCCGA 1 -- int10--------
    rs3685358131,2
    C--18191830(+) CATCT-/AAAAAAAA 2 -- int1 cds10--------
    rs2009264541,2
    C--18191846(-) ACTTTC/TTTTTT 1 -- int10--------
    rs1828863711,2
    --18191847(+) AAAAGA/TAAGTT 1 -- int10--------
    rs1134920701,2
    C--18193377(+) CTTAC-/AAAAA 
    AAAAAAAA
    AAAAA
    1 -- int11Minor allele frequency- AAAAAAAAAAAAA:0.00CSA 2
    rs725222141,2
    C--18199273(+) TGTGT-/GCGTGTG 1 -- int10--------
    rs351656231,2
    C--18219195(+) GATAA-/TTATGA 1 -- int10--------

    HapMap Linkage Disequilibrium report for INO80 (41271078 - 41408552 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for INO80:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2496899CNV Insertion19546169
    dgv2360n71CNV Loss21882294
    nsv904101CNV Loss21882294
    dgv2361n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing INO80
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610169    OMIM disorders: --

    1 disease for INO80:    About MalaCards
    malaria


    INO80 for disorders           About GeneDecksing

    Genetic Association Database (GAD): INO80
    Human Genome Epidemiology (HuGE) Navigator: INO80 (2 documents)

    Export disorders for INO80 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for INO80 gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with INO80)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Roles of human INO80 chromatin remodeling enzyme in DNA replication and chromosome segregation suppress genome instability. (PubMed id 20237820)1, 2, 3 Hur S.K.... Kwon J. (Cell. Mol. Life Sci. 2010)
    2. Characterization of a human SWI2/SNF2 like protein hINO80: demonstration of catalytic and DNA binding activity. (PubMed id 16298340)1, 2, 3 Bakshi R.... Brahmachari V. (Biochem. Biophys. Res. Commun. 2006)
    3. A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex. (PubMed id 16230350)1, 2, 3 Jin J.... Conaway J.W. (J. Biol. Chem. 2005)
    4. Subunit organization of the human INO80 chromatin remodeling complex: An evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. (PubMed id 21303910)1, 2 Chen L.... Conaway R.C. (J. Biol. Chem. 2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. INO80 chromatin remodeling complex promotes the removal of UV lesions by the nucleotide excision repair pathway. (PubMed id 20855601)1, 2 Jiang Y.... Li L. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    7. Human INO80 chromatin-remodelling complex contributes to DNA double- strand break repair via the expression of Rad54B and XRCC3 genes. (PubMed id 20687897)1, 2 Park E.J.... Kwon J. (Biochem. J. 2010)
    8. Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. (PubMed id 18922472)1, 2 Yao T.... Conaway J.W. (Mol. Cell 2008)
    9. A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair. (PubMed id 18026119)1, 2 Wu S.... Shi Y. (Nat. Struct. Mol. Biol. 2007)
    10. YY1 functions with INO80 to activate transcription. (PubMed id 17721549)1, 2 Cai Y.... Conaway J.W. (Nat. Struct. Mol. Biol. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54617 HGNC: 26956 AceView: INO80 Ensembl:ENSG00000128908 euGenes: HUgn54617
    ECgene: INO80 H-InvDB: INO80

    (According to HUGE)
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    HUGE: KIAA1259

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for INO80 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for INO80 gene:
    Search GeneIP for patents involving INO80

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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