Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

INO80 Gene

protein-coding   GIFtS: 48
GCID: GC15M041271

INO80 homolog (S. cerevisiae)

(Previous name: INO80 complex homolog 1 (S. cerevisiae) )
(Previous symbol: INOC1)
  Search for INO80
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for INO80    

Aliases
for INO80 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
INO80 Homolog (S. Cerevisiae)1 2     Ino801
INOC11 2 3 5     INO80 Complex Homolog 1 (S. Cerevisiae)1
INO80A1 2 3     DNA Helicase INO802
HINO801     Homolog Of Yeast INO802
KIAA12591 3     EC 3.6.4.123
Putative DNA Helicase INO80 Complex Homolog 12 3     EC 3.6.18
INO80 Complex Subunit A2 3     EC 3.6.1.238

External Ids:    HGNC: 269561   Entrez Gene: 546172   Ensembl: ENSG000001289087   OMIM: 6101695   UniProtKB: Q9ULG13   

Export aliases for INO80 gene to outside databases

Previous GC identifers: GC15M039058 GC15M018119


Summaries
for INO80 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for INO80:
The protein encoded by this gene represents the catalytic ATPase subunit of the INO80 chromatin remodeling complex.
This complex binds DNA and is recruited by YY1 to activate certain genes.(provided by RefSeq, Apr 2010)

UniProtKB/Swiss-Prot: INO80_HUMAN, Q9ULG1
Function: DNA helicase and probable main scaffold component of the chromatin remodeling INO80 complex which is involved
in transcriptional regulation, DNA replication and probably DNA repair; according to PubMed:20687897 the contribution
to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Recruited by YY1
to YY1-activated genes, where it acts as an essential coactivator. Binds DNA. In vitro, has double stranded
DNA-dependent ATPase activity. Involved in UV-damage excision repair, DNA replication and chromosome segregation
during normal cell division cycle




Genomic Views
for INO80 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the INO80 gene promoter:
         CREB   N-Myc   AREB6   TBP   Nkx6-1   RelA   NF-kappaB1   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: INO80 promoter sequence
   Search SABiosciences Chromatin IP Primers for INO80

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INO80


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15.1   Ensembl cytogenetic band:  15q15.1   HGNC cytogenetic band: 15q15.1

INO80 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INO80 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M041271:  view genomic region     (about GC identifiers)

Start:
 41,271,078 bp from pter      End:
 41,408,552 bp from pter
Size:
 137,475 bases      Orientation:
 minus strand

Proteins
for INO80 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: INO80_HUMAN, Q9ULG1 (See protein sequence)
Recommended Name: DNA helicase INO80  
Size: 1556 amino acids; 176753 Da
Subunit: Component of the chromatin-remodeling INO80 complex; three different complex modules assemble on different
domains of INO80. Interacts with DDB1
Subcellular location: Nucleus. Note=Colocalizes with PCNA at replication forks during S-phase. Recruited to DNA damage
sites in a ACTR8-dependent manner
Sequence caution: Sequence=BAA86573.1; Type=Erroneous initiation;
Secondary accessions: A6H8X4 Q9NTG6

Explore the universe of human proteins at neXtProt for INO80: NX_Q9ULG1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9ULG1

    • 4/23 DME Specific Peptides for INO80 (Q9ULG1) (see all 23)
     KDIESHA  IDIGGGV  NWLANLY  QVTVYRL 

    INO80 Protein expression data from MOPED and PaxDb:    About this image 
    INO80 Protein Expression
    REFSEQ proteins: NP_060023.1  
    ENSEMBL proteins: 
     ENSP00000355205   ENSP00000453677   ENSP00000452806   ENSP00000454057   ENSP00000384686  

    Human Recombinant Protein Products for INO80: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for INO80 
    GenScript Custom Purified and Recombinant Proteins Services for INO80
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for INO80

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA18026119
    GO:0005874microtubule IEA--
    GO:0031011Ino80 complex IDA--

    INO80 for ontologies           About GeneDecksing



    INO80 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for INO80 
    GenScript Custom Superior Antibodies Services for INO80
    Novus Biologicals INO80 Antibodies
    Abcam antibodies for INO80 
    Uscn Antibodies for INO80
    Search ThermoFisher Antibodies for INO80

    Assay Products for INO80: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for INO80
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for INO80

    Protein Domains /
    Families
    for INO80 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    INO80 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR020838 DBINO
     IPR000330 SNF2_N
     IPR014001 Helicase_ATP-bd
     IPR001650 Helicase_C

    Graphical View of Domain Structure for InterPro Entry Q9ULG1

    ProtoNet protein and cluster: Q9ULG1

    1 Blocks protein family: IPB000330 SNF2 related domain

    UniProtKB/Swiss-Prot: INO80_HUMAN, Q9ULG1
    Domain: The DBINO region is involved in binding to DNA
    Similarity: Belongs to the SNF2/RAD54 helicase family
    Similarity: Contains 1 DBINO domain
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    Function
    for INO80 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: INO80_HUMAN, Q9ULG1
    Function: DNA helicase and probable main scaffold component of the chromatin remodeling INO80 complex which is involved
    in transcriptional regulation, DNA replication and probably DNA repair; according to PubMed:20687897 the contribution
    to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Recruited by YY1
    to YY1-activated genes, where it acts as an essential coactivator. Binds DNA. In vitro, has double stranded
    DNA-dependent ATPase activity. Involved in UV-damage excision repair, DNA replication and chromosome segregation
    during normal cell division cycle
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.1.232 EC 3.6.4.121

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA16298340
    GO:0003678DNA helicase activity IDA16298340
    GO:0003779actin binding IEA--
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
         
    INO80 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for INO80 

    miRNA
    Products:            		 OriGene 3'-UTR Clone: INO80
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat INO80
    8/74 QIAGEN miScript miRNA Assays for microRNAs that regulate INO80 (see all 74):
    hsa-miR-576-3p hsa-miR-3938 hsa-miR-642a hsa-miR-520e hsa-miR-106a hsa-miR-93 hsa-miR-3613-3p hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmid: INO80 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for INO80
    OriGene shRNA RFP: INO80
    OriGene siRNA: INO80
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat INO80
    Sirion Biotech Custom design and validation of potent shRNA sequences against INO80 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for INO80
    Sirion Biotech Customized adenovirus for overexpression of INO80 
    Sirion Biotech Customized adenovirus for potent knockdown of INO80

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for INO80 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for INO80
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: INO80 (NM_017553)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INO80
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INO80 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for INO80
    Search LifeMap BioReagents cell lines for INO80
    Sirion Biotech Customized stable knockdown cell line services for INO80 
    Sirion Biotech Customized inducible knockdown cell line services for INO80

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INO80


    Pathways & Interactions
    for INO80 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for INO80

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/98 Interacting proteins for INO80 (Q9ULG11, 3 ENSP000003552054) via UniProtKB, MINT, STRING, and/or I2D (see all 98)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4LP628053, ENSP000003482584I2D: score=3 STRING: ENSP00000348258
    HIST1H4AP628053I2D: score=3 
    HIST1H4BP628053I2D: score=3 
    HIST1H4CP628053I2D: score=3 
    HIST1H4DP628053I2D: score=3 
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000070mitotic sister chromatid segregation IMP--
    GO:0000724double-strand break repair via homologous recombination IMP18026119
    GO:0006200ATP catabolic process IDA16298340
    GO:0006302double-strand break repair IMP--
    GO:0006338chromatin remodeling IDA16298340

    INO80 for ontologies           About GeneDecksing



    Drugs & Compounds
    for INO80 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for INO80
    Search CenterWatch for drugs/clinical trials and news about INO80 

    Transcripts
    for INO80 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for INO80 gene (2 alternative transcripts): 
    NM_017553.1  NM_032196.3  

    Unigene Cluster for INO80:

    INO80 homolog (S. cerevisiae)
    Hs.292949  [show with all ESTs]
    Unigene Representative Sequence: NM_017553
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361937(uc021sjj.1 uc001zni.3 uc010ucu.2) ENST00000558357
    ENST00000558270 ENST00000560689 ENST00000560799 ENST00000561244 ENST00000557849
    ENST00000559995 ENST00000561172 ENST00000401393

    miRNA
    Products:             		 OriGene 3'-UTR Clone: INO80
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat INO80
    8/74 QIAGEN miScript miRNA Assays for microRNAs that regulate INO80 (see all 74):
    hsa-miR-576-3p hsa-miR-3938 hsa-miR-642a hsa-miR-520e hsa-miR-106a hsa-miR-93 hsa-miR-3613-3p hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmid: INO80 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for INO80
    OriGene shRNA RFP: INO80
    OriGene siRNA: INO80
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat INO80
    Sirion Biotech Custom design and validation of potent shRNA sequences against INO80 
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for INO80 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for INO80
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: INO80 (NM_017553)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INO80
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INO80 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for INO80
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat INO80
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INO80
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INO80

    Additional cDNA sequence: 

    AB033085.1 AK002176.1 AK024777.1 AK026050.1 AK057582.1 AK290371.1 AL137280.1 BC012578.1 
    BC046115.2 BC057299.1 BC068054.1 BC105993.1 BC144681.1 BC146785.1 

    8 DOTS entries:

    DT.453868  DT.100021271  DT.95275721  DT.101961365  DT.75128153  DT.100659847  DT.405913  DT.40273088 

    24/139 AceView cDNA sequences (see all 139):

    N57454 BE935906 BX479072 AL137280 CA426271 BQ225120 N29511 AB033085 
    BE766125 BM766476 NM_017553 BE766372 BM681925 CF138382 AA374274 AK057582 
    AA815104 CB155560 AI804829 BF340537 BE382857 CB162390 AW501585 BQ016456 

    GeneLoc Exon Structure


    Expression
    for INO80 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    INO80 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGAGGTGTTT
    INO80 Expression
    About this image

    INO80 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartLeft VentricleHeart
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See INO80 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for INO80

    SOURCE GeneReport for Unigene cluster: Hs.292949

    UniProtKB/Swiss-Prot: INO80_HUMAN, Q9ULG1
    Tissue specificity: According to PubMed:10574462, widely expressed. According to PubMed:16298340, specifically
    expressed in brain, liver and pancreas

        SABiosciences Expression via Pathway-Focused PCR Arrays including INO80: 
              Polycomb & Trithorax Complexes in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for INO80
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat INO80
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INO80
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INO80
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INO80

    Orthologs
    for INO80 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for INO80 gene from 7/26 species (see all 26)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves INO801 INO80 homolog (S. cerevisiae) 80.71(n)
    90.87(a)    		   423210  NM_001199657.1  NP_001186586.1 
    lizard
    (Anolis carolinensis)    		 Reptilia INO806
    		 --
    		 89(a)
    		 1 ↔ 1
    		 1(41836583-41890300)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.90752 Xenopus laevis transcribed sequence with moderate similarity more 79.03(n)    BJ041350.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii ino801 INO80 homolog (S. cerevisiae) 69.07(n)
    75.65(a)    		   566768  NM_001045119.1  NP_001038584.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Ino801 CG31212-PA 52.23(n)
    49.89(a)    		   42314  NM_169854.1  NP_732413.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ATINO806
    		 DNA helicase INO80 complex-like 1
    		 29(a)
    		 1 ↔ 1
    		 3(21199488-21207885)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 SNF2 family N-terminal domain containing protein, ...
    		 29(a)
    		 1 ↔ 1
    		 3(13235401-13246616)


    ENSEMBL Gene Tree for INO80 (if available)
    TreeFam Gene Tree for INO80 (if available) 

    Paralogs
    for INO80 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for INO80 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2415 NCBI SNPs in INO80 are shown (see all 2415)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1496008371,2
    		Cother23269665(+) GCAGCG/AACGCA 2 /R /C mis11Minor allele frequency- A:0.00EU 1323
    rs746010391,2
    		--18119843(+) AATTCC/TGCGAT 1 -- ut310--------
    rs129076651,2
    		C,F--18119930(+) AAACAC/TCTCCC 1 -- ut31 ese32Minor allele frequency- T:0.50NA 4
    rs71754641,2
    		C,H--18120245(+) TGCTAC/TGGTTG 1 -- ut31 ese34Minor allele frequency- T:0.00NS EA 420
    rs764959041,2
    		C,F--18120546(+) ACTTTG/ACAAGG 1 -- ut311Minor allele frequency- A:0.06NA 120
    rs38094901,2
    		C,F,H--18121401(-) TATCTA/GGAGTG 1 -- int15Minor allele frequency- G:0.02NS EA 528
    rs578597481,2
    		C--18121452(+) TGAGAG/ACTGTA 1 -- int12Minor allele frequency- A:0.31WA 120
    rs1132522771,2
    		--18121563(+) AAGTCG/AGGCCA 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs38094891,2
    		H--18121587(-) GAGAGT/CGGGCA 1 -- int14Minor allele frequency- C:0.00NS EA 410
    rs1137986791,2
    		--18121752(+) CAAATC/TCACTT 1 -- int12Minor allele frequency- T:0.02CSA WA 120

    HapMap Linkage Disequilibrium report for INO80 (41271078 - 41408552 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for INO80
         4 CNVs: 76946 87650 87651 102089

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing INO80
    DNA2.0 Custom Variant and Variant Library Synthesis for INO80

    Disorders / Diseases
    for INO80 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    INO80 for disorders           About MalaCards

    INO80 for disorders           About GeneDecksing

    OMIM gene information: 610169    OMIM disorders: --

    Human Genome Epidemiology (HuGE) Navigator: INO80 (2 documents)

    Export disorders for INO80 gene to outside databases

    Publications
    for INO80 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for INO80 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with INO80)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Roles of human INO80 chromatin remodeling enzyme in D NA replication and chromosome segregation suppress genome instability. (PubMed id 20237820)1, 2, 3 Hur S.K....Kwon J. (2010)
    2. Characterization of a human SWI2/SNF2 like protein hINO80: demonstration of catalytic and DNA binding activity. (PubMed id 16298340)1, 2, 3 Bakshi R.... Brahmachari V. (2006)
    3. A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex. (PubMed id 16230350)1, 2, 3 Jin J.... Conaway J.W. (2005)
    4. Subunit organization of the human INO80 chromatin remodeling complex: An evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. (PubMed id 21303910)1, 2 Chen L.... Conaway R.C. (2011)
    5. Human INO80 chromatin-remodelling complex contributes to DNA double-strand break repair via the expression of Rad54B and XRCC3 genes . (PubMed id 20687897)1, 2 Park E.J....Kwon J. (2010)
    6. Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. (PubMed id 18922472)1, 2 Yao T....Conaway J.W. (2008)
    7. A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair. (PubMed id 18026119)1, 2 Wu S.... Shi Y. (2007)
    8. YY1 functions with INO80 to activate transcription. (PubMed id 17721549)1, 2 Cai Y.... Conaway J.W. (2007)
    9. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2 Nagase T.... Ohara O. (1999)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    External Searches for INO80 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing INO80 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54617 HGNC: 26956 AceView: INO80 Ensembl:ENSG00000128908 euGenes: HUgn54617
    ECgene: INO80 H-InvDB: INO80

    Other Databases showing INO80 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1259

    Specialized Databases showing INO80 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for INO80 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for INO80 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for INO80 gene:
    Search GeneIP for patents involving INO80

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for INO80 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for INO80  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for INO80   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for INO80  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for INO80   OriGene 3'-UTR Clone for INO80  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for INO80   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for INO80  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for INO80   OriGene Custom Protein Services for INO80  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat INO80
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing INO80
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INO80
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat INO80
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INO80
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INO80
     GenScript Custom Purified and Recombinant Proteins Services for INO80 GenScript cDNA clones with any tag delivered in your preferred vector for INO80
     GenScript Custom Assay Services for INO80 GenScript Custom Superior Antibodies Services for INO80
     GenScript Custom overexpressing Cell Line Services for INO80 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in INO80 promoter
     Search Chromatin IP Primers for INO80
     RT2 qPCR Primer Assay in human, mouse, rat INO80
     GNC Network for INO80
     SABiosciences PCR Arrays including human, mouse, rat INO80
     Search Tocris compounds for INO80
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     INO80 antibodies
     Antibodies for INO80
     See all of Abcam's Antibodies, Kits and Proteins for INO80
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     INO80 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for INO80
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INO80
     SwitchGear 3'UTR luciferase reporter plasmids for INO80
     SwitchGear Promoter luciferase reporter plasmids for INO80
     Search ThermoFisher Antibodies for INO80
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INO80
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for INO80
    Sirion Biotech Customized:
     stable knockdown cell line services for INO80
     inducible knockdown cell line services for INO80
     design and validation of potent shRNA sequences against INO80
     adenovirus for potent knockdown of INO80
     adenovirus for overexpression of INO80
     stable overexpressing cell line services
     inducible overexpressing cell line services
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      INO80 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4