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Aliases for INO80 Gene

Aliases for INO80 Gene

  • INO80 Complex Subunit 2 3 5
  • INO80 Complex Subunit A 2 3 4
  • Putative DNA Helicase INO80 Complex Homolog 1 3 4
  • INO80A 3 4
  • HINO80 3 4
  • INOC1 3 4
  • INO80 Complex Homolog 1 (S. Cerevisiae) 2
  • INO80 Homolog (S. Cerevisiae) 2
  • Homolog Of Yeast INO80 3
  • INO80 Homolog 3
  • EC 3.6.1.23 63
  • EC 3.6.4.12 4
  • KIAA1259 4
  • EC 3.6.1 63

External Ids for INO80 Gene

Previous HGNC Symbols for INO80 Gene

  • INOC1

Previous GeneCards Identifiers for INO80 Gene

  • GC15M039058
  • GC15M041271
  • GC15M018119

Summaries for INO80 Gene

Entrez Gene Summary for INO80 Gene

  • This gene encodes a subunit of the chromatin remodeling complex, which is classified into subfamilies depending on sequence features apart from the conserved ATPase domain. This protein is the catalytic ATPase subunit of the INO80 chromatin remodeling complex, which is characterized by a DNA-binding domain. This protein is proposed to bind DNA and be recruited by the YY1 transcription factor to activate certain genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for INO80 Gene

INO80 (INO80 Complex Subunit) is a Protein Coding gene. Diseases associated with INO80 include enamel caries and dentin caries. Among its related pathways are DNA Double-Strand Break Repair and Transcription-Coupled Nucleotide Excision Repair (TC-NER). GO annotations related to this gene include actin binding and DNA helicase activity.

UniProtKB/Swiss-Prot for INO80 Gene

  • DNA helicase and probable main scaffold component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; according to PubMed:20687897 the contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Recruited by YY1 to YY1-activated genes, where it acts as an essential coactivator. Binds DNA. In vitro, has double-stranded DNA-dependent ATPase activity. Involved in UV-damage excision repair, DNA replication and chromosome segregation during normal cell division cycle.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INO80 Gene

Genomics for INO80 Gene

Regulatory Elements for INO80 Gene

Promoters for INO80 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around INO80 on UCSC Golden Path with GeneCards custom track

Genomic Location for INO80 Gene

Chromosome:
15
Start:
40,978,880 bp from pter
End:
41,116,354 bp from pter
Size:
137,475 bases
Orientation:
Minus strand

Genomic View for INO80 Gene

Genes around INO80 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INO80 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INO80 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INO80 Gene

Proteins for INO80 Gene

  • Protein details for INO80 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULG1-INO80_HUMAN
    Recommended name:
    DNA helicase INO80
    Protein Accession:
    Q9ULG1
    Secondary Accessions:
    • A6H8X4
    • Q9NTG6

    Protein attributes for INO80 Gene

    Size:
    1556 amino acids
    Molecular mass:
    176753 Da
    Quaternary structure:
    • Component of the chromatin-remodeling INO80 complex; three different complex modules assemble on different domains of INO80. Interacts with DDB1.
    SequenceCaution:
    • Sequence=BAA86573.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for INO80 Gene

Proteomics data for INO80 Gene at MOPED

Post-translational modifications for INO80 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for INO80 Gene

Domains & Families for INO80 Gene

Gene Families for INO80 Gene

Protein Domains for INO80 Gene

Suggested Antigen Peptide Sequences for INO80 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9ULG1

UniProtKB/Swiss-Prot:

INO80_HUMAN :
  • The DBINO region is involved in binding to DNA.
  • Belongs to the SNF2/RAD54 helicase family.
Domain:
  • The DBINO region is involved in binding to DNA.
  • Contains 1 DBINO domain.
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the SNF2/RAD54 helicase family.
genes like me logo Genes that share domains with INO80: view

Function for INO80 Gene

Molecular function for INO80 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
DNA helicase and probable main scaffold component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; according to PubMed:20687897 the contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Recruited by YY1 to YY1-activated genes, where it acts as an essential coactivator. Binds DNA. In vitro, has double-stranded DNA-dependent ATPase activity. Involved in UV-damage excision repair, DNA replication and chromosome segregation during normal cell division cycle.

Enzyme Numbers (IUBMB) for INO80 Gene

Gene Ontology (GO) - Molecular Function for INO80 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA,IDA 16298340
GO:0005515 protein binding IPI 18026119
GO:0043014 alpha-tubulin binding IMP 20237820
genes like me logo Genes that share ontologies with INO80: view
genes like me logo Genes that share phenotypes with INO80: view

Animal Models for INO80 Gene

MGI Knock Outs for INO80:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for INO80 Gene

Localization for INO80 Gene

Subcellular locations from UniProtKB/Swiss-Prot for INO80 Gene

Nucleus. Note=Colocalizes with PCNA at replication forks during S-phase. Recruited to DNA damage sites in a ACTR8-dependent manner.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for INO80 Gene COMPARTMENTS Subcellular localization image for INO80 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 2
endoplasmic reticulum 2
mitochondrion 2
plasma membrane 2
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for INO80 Gene

Pathways & Interactions for INO80 Gene

genes like me logo Genes that share pathways with INO80: view

Gene Ontology (GO) - Biological Process for INO80 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000724 double-strand break repair via homologous recombination IMP 18026119
GO:0010571 positive regulation of nuclear cell cycle DNA replication IMP 20237820
GO:0030307 positive regulation of cell growth IMP 20237820
GO:0032508 DNA duplex unwinding IDA 16298340
GO:0051225 spindle assembly IMP 20237820
genes like me logo Genes that share ontologies with INO80: view

No data available for SIGNOR curated interactions for INO80 Gene

Drugs & Compounds for INO80 Gene

(1) Drugs for INO80 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for INO80 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with INO80: view

Transcripts for INO80 Gene

Unigene Clusters for INO80 Gene

INO80 homolog (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for INO80 Gene

No ASD Table

Relevant External Links for INO80 Gene

GeneLoc Exon Structure for
INO80
ECgene alternative splicing isoforms for
INO80

Expression for INO80 Gene

mRNA expression in normal human tissues for INO80 Gene

Protein differential expression in normal tissues from HIPED for INO80 Gene

This gene is overexpressed in Esophagus (26.1), Monocytes (10.1), Peripheral blood mononuclear cells (8.4), and Adrenal (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for INO80 Gene



SOURCE GeneReport for Unigene cluster for INO80 Gene Hs.292949

mRNA Expression by UniProt/SwissProt for INO80 Gene

Q9ULG1-INO80_HUMAN
Tissue specificity: According to PubMed:10574462, widely expressed. According to PubMed:16298340, specifically expressed in brain, liver and pancreas.
genes like me logo Genes that share expression patterns with INO80: view

Protein tissue co-expression partners for INO80 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for INO80 Gene

Orthologs for INO80 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for INO80 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INO80 35
  • 99.74 (n)
  • 99.94 (a)
INO80 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia INO80 36
  • 97 (a)
OneToOne
INO80 35
  • 93.19 (n)
  • 97.43 (a)
dog
(Canis familiaris)
Mammalia INO80 35
  • 93.93 (n)
  • 98.14 (a)
INO80 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ino80 36
  • 97 (a)
OneToOne
Ino80 16
Ino80 35
  • 90.79 (n)
  • 97.04 (a)
oppossum
(Monodelphis domestica)
Mammalia INO80 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia INO80 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ino80 35
  • 91.02 (n)
  • 97.17 (a)
chicken
(Gallus gallus)
Aves INO80 36
  • 91 (a)
OneToOne
INO80 35
  • 80.71 (n)
  • 90.87 (a)
lizard
(Anolis carolinensis)
Reptilia INO80 36
  • 89 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.9075 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ino80 35
  • 73.58 (n)
  • 81.02 (a)
zebrafish
(Danio rerio)
Actinopterygii ino80 35
  • 69.94 (n)
  • 77.06 (a)
ino80 36
  • 75 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005035 35
  • 54.81 (n)
  • 59.35 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ino80 35
  • 55.51 (n)
  • 55.86 (a)
Ino80 36
  • 43 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes INO80 36
  • 33 (a)
OneToOne
wheat
(Triticum aestivum)
Liliopsida Ta.4945 35
Species with no ortholog for INO80:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • worm (Caenorhabditis elegans)

Evolution for INO80 Gene

ENSEMBL:
Gene Tree for INO80 (if available)
TreeFam:
Gene Tree for INO80 (if available)

Paralogs for INO80 Gene

(3) SIMAP similar genes for INO80 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with INO80: view

No data available for Paralogs for INO80 Gene

Variants for INO80 Gene

Sequence variations from dbSNP and Humsavar for INO80 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs34153025 - 41,047,499(+) ATTAA(C/T)ACCTG nc-transcript-variant, reference, missense
rs34178030 - 41,016,167(+) GCAGG(A/C)CATCA intron-variant, reference, missense
rs566929 -- 41,087,172(+) GAATA(C/T)GTACA intron-variant
rs480549 -- 41,114,744(-) tagca(C/G)gtatc intron-variant
rs485267 -- 41,114,224(-) AGTGG(C/T)GTGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for INO80 Gene

Variant ID Type Subtype PubMed ID
nsv904101 CNV Loss 21882294
dgv2360n71 CNV Loss 21882294
esv2496899 CNV Insertion 19546169
dgv2361n71 CNV Loss 21882294

Variation tolerance for INO80 Gene

Residual Variation Intolerance Score: 2.11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.86; 48.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for INO80 Gene

HapMap Linkage Disequilibrium report
INO80
Human Gene Mutation Database (HGMD)
INO80

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INO80 Gene

Disorders for INO80 Gene

MalaCards: The human disease database

(4) MalaCards diseases for INO80 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
enamel caries
  • dental caries limited to enamel
dentin caries
  • compound dental caries
translocation renal cell carcinoma
  • carcinoma associated with mitf/tfe translocation
occlusion precerebral artery
  • occlusion and stenosis of multiple and bilateral precerebral arteries
- elite association - COSMIC cancer census association via MalaCards
Search INO80 in MalaCards View complete list of genes associated with diseases

Relevant External Links for INO80

Genetic Association Database (GAD)
INO80
Human Genome Epidemiology (HuGE) Navigator
INO80
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
INO80
genes like me logo Genes that share disorders with INO80: view

No data available for UniProtKB/Swiss-Prot and Genatlas for INO80 Gene

Publications for INO80 Gene

  1. Roles of human INO80 chromatin remodeling enzyme in DNA replication and chromosome segregation suppress genome instability. (PMID: 20237820) Hur S.K. … Kwon J. (Cell. Mol. Life Sci. 2010) 2 3 4 67
  2. Characterization of a human SWI2/SNF2 like protein hINO80: demonstration of catalytic and DNA binding activity. (PMID: 16298340) Bakshi R. … Brahmachari V. (Biochem. Biophys. Res. Commun. 2006) 2 3
  3. A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex. (PMID: 16230350) Jin J. … Conaway J.W. (J. Biol. Chem. 2005) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for INO80 Gene

Sources for INO80 Gene

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