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Aliases for INMT-FAM188B Gene

Subcategory (RNA class) for INMT-FAM188B Gene

ncRNA

Quality Score for this RNA gene is

3

Aliases for INMT-FAM188B Gene

  • INMT-FAM188B Readthrough (NMD Candidate) 2 3 5

External Ids for INMT-FAM188B Gene

Previous GeneCards Identifiers for INMT-FAM188B Gene

  • GC07U903112

Summaries for INMT-FAM188B Gene

Entrez Gene Summary for INMT-FAM188B Gene

  • This locus represents rare but naturally occurring read-through transcription between the INMT (indolethylamine N-methyltransferase) and FAM188B (family with sequence similarity 188, member B) genes on chromosome 7. The read-through transcript is unlikely to produce a protein because it is a nonsense-mediated mRNA decay (NMD) candidate based on translation from the supported INMT start codon. [provided by RefSeq, Nov 2010]

GeneCards Summary for INMT-FAM188B Gene

INMT-FAM188B (INMT-FAM188B Readthrough (NMD Candidate)) is an RNA Gene, and is affiliated with the ncRNA class. GO annotations related to this gene include methyltransferase activity. An important paralog of this gene is INMT.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INMT-FAM188B Gene

Genomics for INMT-FAM188B Gene

Regulatory Elements for INMT-FAM188B Gene

Enhancers for INMT-FAM188B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F030755 0.8 Ensembl ENCODE 0.8 +4.5 4499 2.7 CTCF PKNOX1 HLF REST ZKSCAN1 NR2F2 CREB3 JUND CTBP1 ZBTB33 FAM188B CRHR2 INMT INMT-FAM188B
GH07F030748 0.2 ENCODE 0.8 -1.0 -970 5.8 CTCF CBX3 BHLHE40 CEBPG REST RAD21 NR2F2 ATF3 SCRT2 IKZF1 FAM188B CRHR2 INMT ENSG00000244480 INMT-FAM188B ENSG00000223419
GH07F030760 1 ENCODE 0.4 +9.4 9446 1.8 ATF1 PKNOX1 ARNT CREB3L1 ELK1 GATA2 NCOA1 REST SMARCB1 NFIL3 FAM188B ENSG00000244480 INMT-FAM188B
GH07F030764 1 FANTOM5 Ensembl ENCODE 0.4 +12.9 12874 2.0 CTCF JUND BHLHE40 FOS MAFK NR2F2 FAM188B INMT INMT-FAM188B
GH07F030766 0.2 ENCODE 0.4 +14.2 14185 0.2 HNF4G FAM188B INMT-FAM188B
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around INMT-FAM188B on UCSC Golden Path with GeneCards custom track

Promoters for INMT-FAM188B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001890494 1365 201 NR2F2

Genomic Location for INMT-FAM188B Gene

Chromosome:
7
Start:
30,752,135 bp from pter
End:
30,892,387 bp from pter
Size:
140,253 bases
Orientation:
Plus strand

Genomic View for INMT-FAM188B Gene

Genes around INMT-FAM188B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INMT-FAM188B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INMT-FAM188B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INMT-FAM188B Gene

Proteins for INMT-FAM188B Gene

  • Protein details for INMT-FAM188B Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    F8WBC2
    Recommended name:
    Protein INMT-FAM188B
    Protein Accession:
    F8WBC2

    Protein attributes for INMT-FAM188B Gene

    Size:
    141 amino acids
    Molecular mass:
    15818 Da
    Quaternary structure:
    No Data Available
  • Protein details for INMT-FAM188B Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H3BSR8
    Recommended name:
    Protein INMT-FAM188B
    Protein Accession:
    H3BSR8

    Protein attributes for INMT-FAM188B Gene

    Size:
    122 amino acids
    Molecular mass:
    13650 Da
    Quaternary structure:
    No Data Available

neXtProt entry for INMT-FAM188B Gene

Post-translational modifications for INMT-FAM188B Gene

No Post-translational modifications

Other Protein References for INMT-FAM188B Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for INMT-FAM188B Gene

Domains & Families for INMT-FAM188B Gene

Protein Domains for INMT-FAM188B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with INMT-FAM188B: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for INMT-FAM188B Gene

Function for INMT-FAM188B Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for INMT-FAM188B Gene

Localization for INMT-FAM188B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for INMT-FAM188B Gene

Pathways & Interactions for INMT-FAM188B Gene

SuperPathways for INMT-FAM188B Gene

No Data Available

Interacting Proteins for INMT-FAM188B Gene

Gene Ontology (GO) - Biological Process for INMT-FAM188B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with INMT-FAM188B: view

No data available for Pathways by source and SIGNOR curated interactions for INMT-FAM188B Gene

Transcripts for INMT-FAM188B Gene

mRNA/cDNA for INMT-FAM188B Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for INMT-FAM188B Gene

No ASD Table

Relevant External Links for INMT-FAM188B Gene

GeneLoc Exon Structure for
INMT-FAM188B
ECgene alternative splicing isoforms for
INMT-FAM188B

Expression for INMT-FAM188B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for INMT-FAM188B Gene

mRNA differential expression in normal tissues according to GTEx for INMT-FAM188B Gene

This gene is overexpressed in Artery - Coronary (x7.3), Lung (x5.4), and Artery - Tibial (x4.5).
genes like me logo Genes that share expression patterns with INMT-FAM188B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for INMT-FAM188B Gene

Orthologs for INMT-FAM188B Gene

This gene was present in the common ancestor of animals.

Orthologs for INMT-FAM188B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 47 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Inmt 35
  • 28 (a)
OneToMany
cow
(Bos Taurus)
Mammalia INMT 35
  • 27 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 26 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 25 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 26 (a)
ManyToMany
-- 35
  • 24 (a)
ManyToMany
-- 35
  • 24 (a)
ManyToMany
-- 35
  • 24 (a)
ManyToMany
-- 35
  • 24 (a)
ManyToMany
-- 35
  • 6 (a)
ManyToMany
-- 35
  • 6 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii zgc:64002 35 35
  • 21 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea anmt-2 35
  • 15 (a)
ManyToMany
anmt-1 35
  • 11 (a)
ManyToMany
anmt-3 35
  • 11 (a)
ManyToMany
Species where no ortholog for INMT-FAM188B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for INMT-FAM188B Gene

ENSEMBL:
Gene Tree for INMT-FAM188B (if available)
TreeFam:
Gene Tree for INMT-FAM188B (if available)

Paralogs for INMT-FAM188B Gene

Paralogs for INMT-FAM188B Gene

(3) SIMAP similar genes for INMT-FAM188B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with INMT-FAM188B: view

Variants for INMT-FAM188B Gene

Sequence variations from dbSNP and Humsavar for INMT-FAM188B Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs193920790 Uncertain significance 30,755,684(+) GGAAG(C/T)GTGAA intron-variant, reference, missense
rs10155853 -- 30,820,201(+) cggcc(A/G)ATAAT intron-variant
rs10155856 -- 30,820,602(+) aactt(A/C)cggtg intron-variant
rs10156053 -- 30,820,193(+) accgc(A/G)cccgg intron-variant
rs1017012 -- 30,797,387(+) gggac(A/G)gagct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for INMT-FAM188B Gene

Variant ID Type Subtype PubMed ID
dgv1879e212 CNV loss 25503493
dgv6316n100 CNV gain 25217958
esv22626 CNV gain 19812545
esv2390406 CNV deletion 18987734
esv2678492 CNV deletion 23128226
esv2678752 CNV deletion 23128226
esv2734203 CNV deletion 23290073
esv2734204 CNV deletion 23290073
esv2761316 CNV gain 21179565
esv3305464 CNV mobile element insertion 20981092
esv3356059 CNV insertion 20981092
esv3541409 CNV deletion 23714750
esv3571725 CNV loss 25503493
esv3612714 CNV loss 21293372
esv5109 CNV loss 18987735
esv5499 CNV loss 19470904
esv993279 CNV deletion 20482838
nsv1025945 CNV loss 25217958
nsv1068321 OTHER inversion 25765185
nsv1074084 CNV deletion 25765185
nsv1146524 CNV deletion 26484159
nsv1148830 OTHER inversion 26484159
nsv436557 CNV deletion 17901297
nsv464416 CNV loss 19166990
nsv526591 CNV loss 19592680
nsv527038 CNV gain 19592680
nsv606506 CNV loss 21841781
nsv606507 CNV loss 21841781
nsv606508 CNV loss 21841781
nsv606509 CNV loss 21841781
nsv830938 CNV gain 17160897
nsv830939 CNV loss 17160897
nsv955992 CNV deletion 24416366

Variation tolerance for INMT-FAM188B Gene

Gene Damage Index Score: 0.08; 1.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for INMT-FAM188B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
INMT-FAM188B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INMT-FAM188B Gene

Disorders for INMT-FAM188B Gene

Relevant External Links for INMT-FAM188B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
INMT-FAM188B

No disorders were found for INMT-FAM188B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for INMT-FAM188B Gene

Publications for INMT-FAM188B Gene

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3 64
  2. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 64
  3. Toward a complete human genome sequence. (PMID: 9847074) Sulston J.E. … Waterston R. (Genome Res. 1998) 3 64

Products for INMT-FAM188B Gene

Sources for INMT-FAM188B Gene

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