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INMT Gene

protein-coding   GIFtS: 55
GCID: GC07P030737

Indolethylamine N-Methyltransferase

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Indolethylamine N-Methyltransferase1 2     TEMT2 3
Amine N-Methyltransferase2 3     EC 2.1.1.493 8
Aromatic Alkylamine N-Methyltransferase2 3     Nicotine N-Methyltransferase2
Arylamine N-Methyltransferase2 3     EC 2.1.1.963
Indolamine N-Methyltransferase2 3     EC 2.1.18
Thioether S-Methyltransferase2 3     

External Ids:    HGNC: 60691   Entrez Gene: 111852   Ensembl: ENSG000002416447   OMIM: 6048545   UniProtKB: O950503   

Export aliases for INMT gene to outside databases

Previous GC identifers: GC07P030434 GC07P030534 GC07P030564 GC07P030758


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for INMT Gene:
N-methylation of endogenous and xenobiotic compounds is a major method by which they are degraded. This gene
encodes an enzyme that N-methylates indoles such as tryptamine. Alternative splicing results in multiple
transcript variants. Read-through transcription also exists between this gene and the downstream FAM188B (family
with sequence similarity 188, member B) gene. (provided by RefSeq, Nov 2010)

GeneCards Summary for INMT Gene:
INMT (indolethylamine N-methyltransferase) is a protein-coding gene. Diseases associated with INMT include appendicitis, and nephrolithiasis. GO annotations related to this gene include amine N-methyltransferase activity and thioether S-methyltransferase activity. An important paralog of this gene is PNMT.

UniProtKB/Swiss-Prot: INMT_HUMAN, O95050
Function: Functions as thioether S-methyltransferase and is active with a variety of thioethers and the
corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide,
dimethyl telluride, 2-methylthioethylamine, 2-methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide.
Plays an important role in the detoxification of selenium compounds (By similarity). Catalyzes the N-methylation
of tryptamine and structurally related compounds




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007819.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the INMT gene promoter:
         C/EBPbeta   Tal-1   GATA-3   p300   MyoD   GATA-1   YY1   E47   HEN1   HFH-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): INMT promoter sequence
   Search Chromatin IP Primers for INMT

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat INMT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p14.3   Ensembl cytogenetic band:  7p14.3   HGNC cytogenetic band: 7p14.3

INMT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INMT gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P030737:  view genomic region     (about GC identifiers)

Start:
30,737,601 bp from pter      End:
30,797,218 bp from pter
Size:
59,618 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 30,841,304-30,846,771     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: INMT_HUMAN, O95050 (See protein sequence)
Recommended Name: Indolethylamine N-methyltransferase  
Size: 263 amino acids; 28891 Da
Subunit: Monomer (By similarity)
1 PDB 3D structure from and Proteopedia for INMT:
2A14 (3D)    
Secondary accessions: B8ZZ69 Q3KP49 Q9P1Y2 Q9UBY4 Q9UHQ0
Alternative splicing: 2 isoforms:  O95050-1   O95050-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for INMT: NX_O95050

Explore proteomics data for INMT at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for INMT (O95050)
     LAMECAC  LIDIGSG 


    See INMT Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001186148.1  NP_006765.4  

    ENSEMBL proteins: 
     ENSP00000013222   ENSP00000386961  

    INMT Human Recombinant Protein Products:

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    INMT Assay Products:

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    Cloud-Clone Corp. CLIAs for INMT


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR000940 NNMT_TEMT_trans
     IPR025817 Amine_MeTrfase
     IPR025820 NNMT/PNMT/TEMT_CS

    Graphical View of Domain Structure for InterPro Entry O95050

    ProtoNet protein and cluster: O95050

    1 Blocks protein domain: IPB000940 Methyltransferase

    UniProtKB/Swiss-Prot: INMT_HUMAN, O95050
    Similarity: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family


    INMT for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: INMT_HUMAN, O95050
    Function: Functions as thioether S-methyltransferase and is active with a variety of thioethers and the
    corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide,
    dimethyl telluride, 2-methylthioethylamine, 2-methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide.
    Plays an important role in the detoxification of selenium compounds (By similarity). Catalyzes the N-methylation
    of tryptamine and structurally related compounds
    Catalytic activity: S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine
    Catalytic activity: S-adenosyl-L-methionine + dimethyl sulfide = S-adenosyl-L-homocysteine + trimethylsulfonium
    Biophysicochemical properties: Kinetic parameters: KM=2.9 mM for tryptamine;

         Genatlas biochemistry entry for INMT:
    indolethylamine N-metyltransferase,expressed in most tissues but not in the brain,catalyzing the N methylation of
    the tryptamine,serotonine,structurally related indoleamines and beta carbolines

         Enzyme Numbers (IUBMB): EC 2.1.1.491 2 EC 2.1.1.961 EC 2.1.12

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004790thioether S-methyltransferase activity IEA--
    GO:0008168methyltransferase activity ----
    GO:0030748amine N-methyltransferase activity IDA10552930
         
    INMT for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for INMT:
     Decreased influenza A virus in 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for INMT
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for INMT
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for INMT

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    Sino Biological Human cDNA Clone for INMT
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INMT
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    INMT_HUMAN, O95050: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    plasma membrane2
    extracellular1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol IDA10552930

    INMT for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for INMT About    
    See pathways by source

    SuperPathContained pathways About
    1Tryptophan metabolism
    Tryptophan metabolism0.46
    Tryptophan metabolism0.46
    2acetone degradation I (to methylglyoxal)
    nicotine degradation IV0.33
    3Selenocompound metabolism
    Selenocompound metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for INMT
        nicotine degradation IV
    Tryptophan metabolism



    2 Kegg Pathways  (Kegg details for INMT):
        Tryptophan metabolism
    Selenocompound metabolism


    INMT for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including INMT: 
              Amino Acid Metabolism I in human mouse rat
              Drug Metabolism: Phase II Enzymes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for INMT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for INMT (O950503 ENSP000000132224) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KCNMA1Q127913I2D: score=1 
    FMO1ENSP000003469014STRING: ENSP00000346901
    IDO1ENSP000002535134STRING: ENSP00000253513
    AANATENSP000002506154STRING: ENSP00000250615
    AOC1ENSP000003541934STRING: ENSP00000354193
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009308amine metabolic process IDA10552930
    GO:0009636response to toxic substance IEA--
    GO:0032259methylation IDA10552930

    INMT for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for INMT

    8 HMDB Compounds for INMT    About this table
    CompoundSynonyms CAS #PubMed Ids
    5-Hydroxyindoleacetaldehyde(5-hydroxy-1H-indol-3-yl)acetaldehyde (see all 6)1892-21-3--
    L-Methionine(2S)-2-amino-4-(methylsulfanyl)butanoic acid (see all 54)63-68-3--
    N-Methylserotonin3-(2-(methylamino)ethyl)-1H-indol-5-ol (see all 3)1134-01-6--
    N-Methyltryptamine1-Methyl-2-(3-indolyl)ethylamine (see all 9)61-49-4--
    S-Adenosylhomocysteine(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)979-92-0--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--
    Serotonin3-(2-Aminoethyl)-1H-indol-5-ol (see all 14)50-67-9--
    Tryptamine(3-Indolyl)ethylamine (see all 13)61-54-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for INMT gene (2 alternative transcripts): 
    NM_001199219.1  NM_006774.4  

    Unigene Cluster for INMT:

    Indolethylamine N-methyltransferase
    Hs.632629  [show with all ESTs]
    Unigene Representative Sequence: NM_006774
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000484180 ENST00000461246 ENST00000013222(uc010kwc.1 uc003tbs.1 uc010kwd.1)
    ENST00000409539
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat INMT

    Additional mRNA sequence: 

    AF128846.1 AF128847.1 AK309519.1 AK313832.1 BC033813.1 BC103712.1 BC106902.1 BC106903.1 

    2 DOTS entries:

    DT.92416197  DT.100645357 

    Selected AceView cDNA sequences (see all 170):

    AA487680 AI301264 BQ019050 BQ015743 AI654718 BQ029558 BU743187 CF125241 
    BM972025 BQ722411 AW084658 CF127609 AI650766 BE220148 AI131260 AA442346 
    AW166482 AK026027 BU160706 CA444425 BM993237 BM972420 F01784 BF221501 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    INMT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGGCACAC
    INMT Expression
    About this image


    INMT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Cerebral Cortex
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord blood-derived hematopoietic stem cells
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Umbilical cord blood-derived hematopoietic stem cells
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Epithelial Cells
             Mature Choroid Plexus Cells Choroid Plexus
    INMT Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    INMT Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632629

    UniProtKB/Swiss-Prot: INMT_HUMAN, O95050
    Tissue specificity: Widely expressed. The highest levels were in thyroid, adrenal gland, adult and fetal lung.
    Intermediate levels in heart, placenta, skeletal muscle, testis, small intestine, pancreas, stomach, spinal cord,
    lymph node and trachea. Very low levels in adult and fetal kidney and liver, in adult spleen, thymus, ovary,
    colon and bone marrow. Not expressed in peripheral blood leukocytes and brain

        Pathway & Disease-focused RT2 Profiler PCR Arrays including INMT: 
              Amino Acid Metabolism I in human mouse rat
              Drug Metabolism: Phase II Enzymes in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for INMT
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INMT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for INMT gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Inmt1 , 5 indolethylamine N-methyltransferase1, 5 65.5(n)1
    58.75(a)1
      6 (27.38 cM)5
    217431  NM_009349.31  NP_033375.11 
     551706265 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 7)
    Uncharacterized protein
    (see all 7)
    48(a)
    48(a)
    (see all 7)
    many ↔ many
    many ↔ many
    (see all 7)
    GL343521.1(402825-410630)
    GL343722.1(158417-161010)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC061684.12   -- 69.61(n)    BC061684.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:640021 zgc:64002 47.71(n)
    39.61(a)
      393330  NM_001111246.2  NP_001104716.2 
    worm
    (Caenorhabditis elegans)
    Secernentea anmt-26
    anmt-36
    (see all 3)
    Protein ANMT-3 (anmt-3) mRNA, complete cds
    (see all 3)
    26(a)
    22(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    III(6154714-6157758) WBGene00018340
    V(9956880-9958331) WBGene00011573


    ENSEMBL Gene Tree for INMT (if available)
    TreeFam Gene Tree for INMT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for INMT gene
    PNMT2  NNMT2  INMT-FAM188B2  
    3 SIMAP similar genes for INMT using alignment to 2 protein entries:     INMT_HUMAN (see all proteins):
    INMT-FAM188B    NNMT    PNMT

    INMT for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    7 SNPs for INMT    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs23023401,2,4
    ----see VAR_0116172 mis40--------
    rs568002851,2,4
    ----see VAR_0613732 mis40--------
    rs69706051,2,4
    ----see VAR_0369942 mis40--------
    rs23023391,2,4
    ----see VAR_0116162 mis40--------
    rs69702101,2,4
    ----see VAR_0369922 mis40--------
    rs47230101,2,4
    ----see VAR_0369912 mis40--------
    rs47200151,2,4
    ----see VAR_0369932 mis40--------

    HapMap Linkage Disequilibrium report for INMT (30737601 - 30797218 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for INMT:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv436557CNV Deletion17901297
    nsv830939CNV Loss17160897
    nsv830938CNV Gain17160897
    nsv527038CNV Gain19592680

    Human Gene Mutation Database (HGMD): INMT
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing INMT
    DNA2.0 Custom Variant and Variant Library Synthesis for INMT

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604854    OMIM disorders: --

    5 diseases for INMT:    
    About MalaCards
    appendicitis    nephrolithiasis    choroiditis    thyroiditis
    cerebritis


    INMT for disorders           About GeneDecksing

    Genetic Association Database (GAD): INMT
    Human Genome Epidemiology (HuGE) Navigator: INMT (3 documents)

    Export disorders for INMT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for INMT gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with INMT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human indolethylamine N-methyltransferase: cDNA cloning and expression, gene cloning, and chromosomal localization. (PubMed id 10552930)1, 2, 3, 9 Thompson M.A....Weinshilboum R.M. (Genomics 1999)
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    5. Potentially hallucinogenic 5-hydroxytryptamine receptor ligands bufotenine and dimethyltryptamine in blood and tissues. (PubMed id 16095048)1, 9 KAorkkAoinen J....Hesso A. (Scand. J. Clin. Lab. Invest. 2005)
    6. A genome-wide association study of nephrolithiasis in the Japanese population identifies novel susceptible Loci at 5q35.3, 7p14.3, and 13q14.1. (PubMed id 22396660)1 Urabe Y....Matsuda K. (PLoS Genet. 2012)
    7. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    8. Differences in gene expression levels between early and later stages of human lung development are opposite to those between normal lung tissue and non-small lung cell carcinoma. (PubMed id 18394749)1 Kopantzev E.P....Sverdlov E.D. (Lung Cancer 2008)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    10. Human-specific amino acid changes found in 103 protein-coding genes. (PubMed id 15014171)2 Kitano T.... Saitou N. (Mol. Biol. Evol. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11185 HGNC: 6069 AceView: INMTandFLJ22374 Ensembl:ENSG00000241644 euGenes: HUgn11185
    ECgene: INMT Kegg: 11185 H-InvDB: INMT

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for INMT Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for INMT gene:
    Search GeneIP for patents involving INMT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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