Aliases for INMT Gene
External Ids for INMT Gene
Previous GeneCards Identifiers for INMT Gene
N-methylation of endogenous and xenobiotic compounds is a major method by which they are degraded. This gene encodes an enzyme that N-methylates indoles such as tryptamine. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream FAM188B (family with sequence similarity 188, member B) gene. [provided by RefSeq, Nov 2010]
GeneCards Summary for INMT Gene
INMT (Indolethylamine N-Methyltransferase) is a Protein Coding gene. Among its related pathways are Selenocompound metabolism and Tryptophan metabolism. GO annotations related to this gene include thioether S-methyltransferase activity and amine N-methyltransferase activity. An important paralog of this gene is NNMT.
UniProtKB/Swiss-Prot for INMT Gene
Functions as thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2-methylthioethylamine, 2-methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide. Plays an important role in the detoxification of selenium compounds (By similarity). Catalyzes the N-methylation of tryptamine and structurally related compounds.