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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

INMT Gene

protein-coding   GIFtS: 55
GCID: GC07P030737

indolethylamine N-methyltransferase
 Explore 4 diseases affiliated with
INMT via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for INMT    

Aliases
for INMT gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Indolethylamine N-Methyltransferase1 2     TEMT2 3
Amine N-Methyltransferase2 3     EC 2.1.1.493 8
Aromatic Alkylamine N-Methyltransferase2 3     Nicotine N-Methyltransferase2
Arylamine N-Methyltransferase2 3     EC 2.1.1.963
Indolamine N-Methyltransferase2 3     EC 2.1.18
Thioether S-Methyltransferase2 3     

External Ids:    HGNC: 60691   Entrez Gene: 111852   Ensembl: ENSG000002416447   OMIM: 6048545   UniProtKB: O950503   

Export aliases for INMT gene to outside databases

Previous GC identifers: GC07P030434 GC07P030534 GC07P030564 GC07P030758


Summaries
for INMT gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for INMT:
N-methylation of endogenous and xenobiotic compounds is a major method by which they are degraded. This gene encodes an
enzyme that N-methylates indoles such as tryptamine. Alternative splicing results in multiple transcript variants.
Read-through transcription also exists between this gene and the downstream FAM188B (family with sequence similarity
188, member B) gene. (provided by RefSeq, Nov 2010)

UniProtKB/Swiss-Prot: INMT_HUMAN, O95050
Function: Functions as thioether S-methyltransferase and is active with a variety of thioethers and the corresponding
selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride,
2-methylthioethylamine, 2-methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide. Plays an important role in
the detoxification of selenium compounds (By similarity). Catalyzes the N-methylation of tryptamine and structurally
related compounds




Genomic Views
for INMT gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the INMT gene promoter:
         C/EBPbeta   Tal-1   GATA-3   p300   MyoD   GATA-1   YY1   E47   HEN1   HFH-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): INMT promoter sequence
   Search SABiosciences Chromatin IP Primers for INMT

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INMT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p14.3   Ensembl cytogenetic band:  7p14.3   HGNC cytogenetic band: 7p14.3

INMT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INMT gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P030737:  view genomic region     (about GC identifiers)

Start:
 30,737,601 bp from pter      End:
 30,797,218 bp from pter
Size:
 59,618 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 30,841,304-30,846,771     

Proteins
for INMT gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: INMT_HUMAN, O95050 (See protein sequence)
Recommended Name: Indolethylamine N-methyltransferase  
Size: 263 amino acids; 28891 Da
Subunit: Monomer (By similarity)
Subcellular location: Cytoplasm (By similarity)
1 PDB 3D structure from and Proteopedia for INMT:
2A14 (3D)    
Secondary accessions: B8ZZ69 Q3KP49 Q9P1Y2 Q9UBY4 Q9UHQ0
Alternative splicing: 2 isoforms:  O95050-1   O95050-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for INMT: NX_O95050

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95050

    • 2 DME Specific Peptides for INMT (O95050)
     LAMECAC  LIDIGSG 

    INMT Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001186148.1  NP_006765.4  

    ENSEMBL proteins: 
     ENSP00000013222   ENSP00000386961  

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    Novus Biologicals INMT Protein
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    Uscn Proteins for INMT

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol IDA10552930


    INMT for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for INMT

    Protein Domains /
    Families
    for INMT gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    INMT for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR025817 Indoethylamine_MeTrfase
     IPR000940 NNMT_TEMT_trans
     IPR025820 NNMT/PNMT/TEMT_CS

    Graphical View of Domain Structure for InterPro Entry O95050

    ProtoNet protein and cluster: O95050

    1 Blocks protein family: IPB000940 Methyltransferase

    UniProtKB/Swiss-Prot: INMT_HUMAN, O95050
    Similarity: Belongs to the NNMT/PNMT/TEMT family


    Function
    for INMT gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: INMT_HUMAN, O95050
    Function: Functions as thioether S-methyltransferase and is active with a variety of thioethers and the corresponding
    selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride,
    2-methylthioethylamine, 2-methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide. Plays an important role in
    the detoxification of selenium compounds (By similarity). Catalyzes the N-methylation of tryptamine and structurally
    related compounds
    Catalytic activity: S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine
    Catalytic activity: S-adenosyl-L-methionine + dimethyl sulfide = S-adenosyl-L-homocysteine + trimethylsulfonium
    Biophysicochemical properties: Kinetic parameters: KM=2.9 mM for tryptamine;

         Genatlas biochemistry entry for INMT:
    indolethylamine N-metyltransferase,expressed in most tissues but not in the brain,catalyzing the N methylation of the
    tryptamine,serotonine,structurally related indoleamines and beta carbolines

    Enzyme Numbers (IUBMB): EC 2.1.1.491 2 EC 2.1.1.961 EC 2.1.12

    miRNA
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    Inhib. RNA
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    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004790thioether S-methyltransferase activity IEA--
    GO:0008168methyltransferase activity ----
    GO:0030748amine N-methyltransferase activity IDA10552930


    INMT for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for INMT:
     Decreased influenza A virus in 


    Pathways & Interactions
    for INMT gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Tryptophan metabolism
    		Tryptophan metabolism1.00
    		Tryptophan metabolism0.47
    2Selenocompound metabolism
    		Selenocompound metabolism1.00
    3nicotine degradation III
    		nicotine degradation IV0.62

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 BioSystems Pathways for INMT 
        nicotine degradation IV
    Tryptophan metabolism


    2         Kegg Pathways  (Kegg details for INMT):
        Tryptophan metabolism
    Selenocompound metabolism


    INMT for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for INMT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/15 Interacting proteins for INMT (O950503 ENSP000000132224) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KCNMA1Q127913I2D: score=1 
    FMO1ENSP000003469014STRING: ENSP00000346901
    IDO1ENSP000002535134STRING: ENSP00000253513
    AANATENSP000002506154STRING: ENSP00000250615
    ABP1ENSP000003541934STRING: ENSP00000354193
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009308amine metabolic process IDA10552930
    GO:0009636response to toxin IEA--
    GO:0032259methylation IDA10552930


    INMT for ontologies           About GeneDecksing



    Drugs & Compounds
    for INMT gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for INMT

    8 HMDB Compounds for INMT    About this table
    CompoundSynonyms CAS #PubMed Ids
    5-Hydroxyindoleacetaldehyde(5-hydroxy-1H-indol-3-yl)acetaldehyde (see all 6)1892-21-3--
    L-Methionine(2S)-2-amino-4-(methylsulfanyl)butanoic acid (see all 54)63-68-3--
    N-Methylserotonin3-(2-(methylamino)ethyl)-1H-indol-5-ol (see all 3)1134-01-6--
    N-Methyltryptamine1-Methyl-2-(3-indolyl)ethylamine (see all 9)61-49-4--
    S-Adenosylhomocysteine(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)979-92-0--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--
    Serotonin3-(2-Aminoethyl)-1H-indol-5-ol (see all 14)50-67-9--
    Tryptamine(3-Indolyl)ethylamine (see all 13)61-54-1--
    Search CenterWatch for drugs/clinical trials and news about INMT 

    Transcripts
    for INMT gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for INMT gene (2 alternative transcripts): 
    NM_001199219.1  NM_006774.4  

    Unigene Cluster for INMT:

    Indolethylamine N-methyltransferase
    Hs.632629  [show with all ESTs]
    Unigene Representative Sequence: NM_006774
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000484180 ENST00000461246 ENST00000013222(uc010kwc.1 uc003tbs.1 uc010kwd.1)
    ENST00000409539

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    SwitchGear 3'UTR luciferase reporter plasmid: INMT 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF128846.1 AF128847.1 AK309519.1 AK313832.1 BC033813.1 BC103712.1 BC106902.1 BC106903.1 

    2 DOTS entries:

    DT.92416197  DT.100645357 

    24/170 AceView cDNA sequences (see all 170):

    AW166482 BQ722411 F01784 CA444425 BQ015743 AI654718 AW304891 BM972420 
    AA442346 BQ019050 BQ029558 CF125241 CF127609 BU743187 BE671856 AA487680 
    AW084658 BU160706 BE220148 BU172312 BM993237 AK026027 AW172262 AI650766 

    GeneLoc Exon Structure


    Expression
    for INMT gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    INMT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGGGCACAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    INMT expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    AdiposeVisceral White AdiposeVisceral White AdipocytesAdipose
    AdiposeVisceral White AdiposeAdipose
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See INMT Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for INMT

    SOURCE GeneReport for Unigene cluster: Hs.632629

    UniProtKB/Swiss-Prot: INMT_HUMAN, O95050
    Tissue specificity: Widely expressed. The highest levels were in thyroid, adrenal gland, adult and fetal lung.
    Intermediate levels in heart, placenta, skeletal muscle, testis, small intestine, pancreas, stomach, spinal cord,
    lymph node and trachea. Very low levels in adult and fetal kidney and liver, in adult spleen, thymus, ovary, colon and
    bone marrow. Not expressed in peripheral blood leukocytes and brain

        SABiosciences Expression via Pathway-Focused PCR Arrays including INMT: 
              Amino Acid Metabolism I in human mouse rat
              Drug Metabolism: Phase II Enzymes in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for INMT gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for INMT gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 6)    		 --
    		 50(a)
    48(a)
    (see all 6)    		 many ↔ many
    many ↔ many
    (see all 6)    		 GL343521.1(402879-408143)
    GL343722.1(158417-161010)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BC061684.12   -- 69.61(n)    BC061684.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:640026
    CU929163.16
    		 --
    		 38(a)
    37(a)
    		 many ↔ many
    many ↔ many
    		 11(12109700-12113560)
    11(12487641-12497046)
    worm
    (Caenorhabditis elegans)    		 Secernentea F42A10.36
    T07C12.96
    (see all 3)    		 Protein T07C12.9
    (see all 3)    		 26(a)
    21(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 III(6154662-6157706)
    V(9956856-9958307)


    ENSEMBL Gene Tree for INMT (if available)
    TreeFam Gene Tree for INMT (if available) 

    Paralogs
    for INMT gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for INMT gene
    PNMT2  NNMT2  INMT-FAM188B2  
    3 SIMAP similar genes for INMT using alignment to 2 protein entries:     INMT_HUMAN (see all proteins):
    INMT-FAM188B    NNMT    PNMT

    INMT for paralogs           About GeneDecksing



    Genomic Variants
    for INMT gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/194 NCBI SNPs in INMT are shown (see all 194)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1439100121,2
    		--30789785(+) ATGGCC/TGGGGA 3 -- us2k10--------
    rs1502059541,2
    		--30789869(+) GCTTGC/TGCAGG 3 -- us2k10--------
    rs745041581,2
    		C--30789920(+) ATTCAA/GTATCA 3 -- us2k10--------
    rs784434161,2
    		C,--30789926(+) TATCAT/CGAGAA 3 -- us2k12Minor allele frequency- C:0.11WA 120
    rs1386784581,2
    		--30789969(+) TTACTC/TCCCAC 3 -- us2k10--------
    rs1810085271,2
    		--30789975(+) CCCACC/TGGGTC 3 -- us2k10--------
    rs1495390311,2
    		--30789976(+) CCACCA/GGGTCC 3 -- us2k10--------
    rs1441067551,2
    		--30789992(+) ACAACA/GTGTGG 3 -- us2k10--------
    rs69593811,2
    		C,F,A,H,--30790078(+) GCTGCC/TGCAGG 3 -- us2k16Minor allele frequency- T:0.48NA WA CSA EA 364
    rs1399309111,2
    		--30790136(+) CCTCCA/GTGCTG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for INMT (30737601 - 30797218 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for INMT: --
    Human Gene Mutation Database (HGMD): INMT

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    Disorders / Diseases
    for INMT gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    INMT for disorders           About GeneDecksing

    OMIM gene information: 604854    OMIM disorders: --

    4 diseases for INMT:    About MalaCards
    appendicitis    homocysteine    thyroiditis    carcinoma

    Human Genome Epidemiology (HuGE) Navigator: INMT (3 documents)

    Export disorders for INMT gene to outside databases

    Publications
    for INMT gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for INMT gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with INMT)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human indolethylamine N-methyltransferase: cDNA cloning and expression, gene cloning, and chromosomal localization. (PubMed id 10552930)1, 2, 3, 9 Thompson M.A....Weinshilboum R.M. (1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    4. Potentially hallucinogenic 5-hydroxytryptamine receptor ligands bufotenine and dimethyltryptamine in blood and tissues. (PubMed id 16095048)1, 9 Karkkainen J....Hesso A. (2005)
    5. A genome-wide association study of nephrolithiasis in the Japanese population identifies novel susceptible Loci at 5q35.3, 7p14.3, and 13q14.1. (PubMed id 22396660)1 Urabe Y....Matsuda K. (2012)
    6. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
    7. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    8. Differences in gene expression levels between early and later stages of human lung development are opposite to those between normal lung tissue and non-small lung cell carcinoma. (PubMed id 18394749)1 Kopantzev E.P....Sverdlov E.D. (2008)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    10. Human-specific amino acid changes found in 103 protein-coding genes. (PubMed id 15014171)2 Kitano T.... Saitou N. (2004)

    External Searches for INMT gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing INMT gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11185 HGNC: 6069 AceView: INMTandFLJ22374 Ensembl:ENSG00000241644 euGenes: HUgn11185
    ECgene: INMT Kegg: 11185 H-InvDB: INMT

    Other Databases showing INMT gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing INMT gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for INMT Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for INMT gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for INMT gene:
    Search GeneIP for patents involving INMT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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