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Aliases for INMT Gene

Aliases for INMT Gene

  • Indolethylamine N-Methyltransferase 2 3
  • Aromatic Alkylamine N-Methyltransferase 3 4
  • Indolamine N-Methyltransferase 3 4
  • Arylamine N-Methyltransferase 3 4
  • Thioether S-Methyltransferase 3 4
  • Amine N-Methyltransferase 3 4
  • EC 2.1.1.49 4 64
  • TEMT 3 4
  • Nicotine N-Methyltransferase 3
  • EC 2.1.1.96 4
  • EC 2.1.1 64

External Ids for INMT Gene

Summaries for INMT Gene

Entrez Gene Summary for INMT Gene

  • N-methylation of endogenous and xenobiotic compounds is a major method by which they are degraded. This gene encodes an enzyme that N-methylates indoles such as tryptamine. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream FAM188B (family with sequence similarity 188, member B) gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for INMT Gene

INMT (Indolethylamine N-Methyltransferase) is a Protein Coding gene. Among its related pathways are Selenocompound metabolism and Tryptophan metabolism. GO annotations related to this gene include thioether S-methyltransferase activity and amine N-methyltransferase activity. An important paralog of this gene is NNMT.

UniProtKB/Swiss-Prot for INMT Gene

  • Functions as thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2-methylthioethylamine, 2-methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide. Plays an important role in the detoxification of selenium compounds (By similarity). Catalyzes the N-methylation of tryptamine and structurally related compounds.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INMT Gene

Genomics for INMT Gene

Genomic Location for INMT Gene

Start:
30,697,985 bp from pter
End:
30,757,602 bp from pter
Size:
59,618 bases
Orientation:
Plus strand

Genomic View for INMT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for INMT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INMT Gene

Regulatory Elements for INMT Gene

Proteins for INMT Gene

  • Protein details for INMT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95050-INMT_HUMAN
    Recommended name:
    Indolethylamine N-methyltransferase
    Protein Accession:
    O95050
    Secondary Accessions:
    • B8ZZ69
    • Q3KP49
    • Q9P1Y2
    • Q9UBY4
    • Q9UHQ0

    Protein attributes for INMT Gene

    Size:
    263 amino acids
    Molecular mass:
    28891 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for INMT Gene

    Alternative splice isoforms for INMT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for INMT Gene

Proteomics data for INMT Gene at MOPED

Selected DME Specific Peptides for INMT Gene

Post-translational modifications for INMT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for INMT Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for INMT Gene

UniProtKB/Swiss-Prot:

INMT_HUMAN
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.:
    • O95050
genes like me logo Genes that share domains with INMT: view

No data available for Gene Families for INMT Gene

Function for INMT Gene

Molecular function for INMT Gene

GENATLAS Biochemistry: indolethylamine N-metyltransferase,expressed in most tissues but not in the brain,catalyzing the N methylation of the tryptamine,serotonine,structurally related indoleamines and beta carbolines
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=2.9 mM for tryptamine {ECO:0000269 PubMed:10552930};
UniProtKB/Swiss-Prot CatalyticActivity: S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine.
UniProtKB/Swiss-Prot CatalyticActivity: S-adenosyl-L-methionine + dimethyl sulfide = S-adenosyl-L-homocysteine + trimethylsulfonium.
UniProtKB/Swiss-Prot Function: Functions as thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2-methylthioethylamine, 2-methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide. Plays an important role in the detoxification of selenium compounds (By similarity). Catalyzes the N-methylation of tryptamine and structurally related compounds.

Enzyme Numbers (IUBMB) for INMT Gene

Gene Ontology (GO) - Molecular Function for INMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004790 thioether S-methyltransferase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0008168 methyltransferase activity --
GO:0030748 amine N-methyltransferase activity IDA 10552930
genes like me logo Genes that share ontologies with INMT: view

Phenotypes for INMT Gene

GenomeRNAi human phenotypes for INMT:
genes like me logo Genes that share phenotypes with INMT: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for INMT Gene

Localization for INMT Gene

Subcellular locations from UniProtKB/Swiss-Prot for INMT Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for INMT Gene COMPARTMENTS Subcellular localization image for INMT gene
Compartment Confidence
cytosol 5
plasma membrane 2
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for INMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 10552930
genes like me logo Genes that share ontologies with INMT: view

Pathways for INMT Gene

genes like me logo Genes that share pathways with INMT: view

Pathways by source for INMT Gene

2 BioSystems pathways for INMT Gene
2 KEGG pathways for INMT Gene

Interacting Proteins for INMT Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000013222%0d%0a9606.ENSP00000356230%0d%0a
Selected Interacting proteins: ENSP00000013222 O95050-INMT_HUMAN for INMT Gene via STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for INMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009308 amine metabolic process IDA 10552930
GO:0009636 response to toxic substance IEA --
GO:0032259 methylation IDA 10552930
genes like me logo Genes that share ontologies with INMT: view

Compounds for INMT Gene

(8) HMDB Compounds for INMT Gene

Compound Synonyms Cas Number PubMed IDs
5-Hydroxyindoleacetaldehyde
  • (5-hydroxy-1H-indol-3-yl)acetaldehyde
1892-21-3
L-Methionine
  • (2S)-2-amino-4-(methylsulfanyl)butanoic acid
63-68-3
N-Methylserotonin
  • 3-(2-(methylamino)ethyl)-1H-indol-5-ol
1134-01-6
N-Methyltryptamine
  • 1-Methyl-2-(3-indolyl)ethylamine
61-49-4
S-Adenosylhomocysteine
  • (S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine
979-92-0
genes like me logo Genes that share compounds with INMT: view

Transcripts for INMT Gene

Unigene Clusters for INMT Gene

Indolethylamine N-methyltransferase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for INMT Gene

No ASD Table

Relevant External Links for INMT Gene

GeneLoc Exon Structure for
INMT
ECgene alternative splicing isoforms for
INMT

Expression for INMT Gene

mRNA expression in normal human tissues for INMT Gene

mRNA differential expression in normal tissues according to GTEx for INMT Gene

This gene is overexpressed in Lung (10.2) and Artery - Coronary (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for INMT Gene

SOURCE GeneReport for Unigene cluster for INMT Gene Hs.632629

mRNA Expression by UniProt/SwissProt for INMT Gene

O95050-INMT_HUMAN
Tissue specificity: Widely expressed. The highest levels were in thyroid, adrenal gland, adult and fetal lung. Intermediate levels in heart, placenta, skeletal muscle, testis, small intestine, pancreas, stomach, spinal cord, lymph node and trachea. Very low levels in adult and fetal kidney and liver, in adult spleen, thymus, ovary, colon and bone marrow. Not expressed in peripheral blood leukocytes and brain.
genes like me logo Genes that share expressions with INMT: view

Orthologs for INMT Gene

This gene was present in the common ancestor of animals.

Orthologs for INMT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 99 (a)
OneToMany
INMT 36
  • 99.37 (n)
  • 98.86 (a)
cow
(Bos Taurus)
Mammalia INMT 36
  • 63.87 (n)
  • 55.73 (a)
INMT 37
  • 56 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 48 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Inmt 36
  • 65.5 (n)
  • 58.75 (a)
Inmt 16
Inmt 37
  • 57 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 48 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Inmt 36
  • 64.07 (n)
  • 58.37 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 45 (a)
ManyToMany
-- 37
  • 48 (a)
ManyToMany
-- 37
  • 43 (a)
ManyToMany
-- 37
  • 48 (a)
ManyToMany
-- 37
  • 45 (a)
ManyToMany
-- 37
  • 44 (a)
ManyToMany
-- 37
  • 47 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC107884 36
  • 57.18 (n)
  • 51.63 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:64002 36
  • 47.71 (n)
  • 39.61 (a)
zgc:64002 37
  • 39 (a)
ManyToMany
zgc:64002 37
  • 38 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea anmt-1 37
  • 21 (a)
ManyToMany
anmt-2 37
  • 26 (a)
ManyToMany
anmt-3 37
  • 22 (a)
ManyToMany
Species with no ortholog for INMT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for INMT Gene

ENSEMBL:
Gene Tree for INMT (if available)
TreeFam:
Gene Tree for INMT (if available)

Paralogs for INMT Gene

Paralogs for INMT Gene

Selected SIMAP similar genes for INMT Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with INMT: view

Variants for INMT Gene

Sequence variations from dbSNP and Humsavar for INMT Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
VAR_011616 -
VAR_011617 -
VAR_036991 -
VAR_036992 -
VAR_036993 -

Structural Variations from Database of Genomic Variants (DGV) for INMT Gene

Variant ID Type Subtype PubMed ID
nsv436557 CNV Deletion 17901297
nsv527038 CNV Gain 19592680
nsv830938 CNV Gain 17160897
nsv830939 CNV Loss 17160897

Relevant External Links for INMT Gene

HapMap Linkage Disequilibrium report
INMT
Human Gene Mutation Database (HGMD)
INMT

Disorders for INMT Gene

Relevant External Links for INMT

Genetic Association Database (GAD)
INMT
Human Genome Epidemiology (HuGE) Navigator
INMT
genes like me logo Genes that share disorders with INMT: view

No data available for UniProtKB/Swiss-Prot for INMT Gene

Publications for INMT Gene

  1. Human indolethylamine N-methyltransferase: cDNA cloning and expression, gene cloning, and chromosomal localization. (PMID: 10552930) Thompson M.A. … Weinshilboum R.M. (Genomics 1999) 2 3 4 23
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 49
  3. Potentially hallucinogenic 5-hydroxytryptamine receptor ligands bufotenine and dimethyltryptamine in blood and tissues. (PMID: 16095048) KAorkkAoinen J. … Hesso A. (Scand. J. Clin. Lab. Invest. 2005) 3 23
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for INMT Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate INMT
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for INMT
    • Block miRNA regulation of INMT using miScript Target Protectors
    • Addgene plasmids for INMT

    Sources for INMT Gene

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