Free for academic non-profit institutions. Other users need a Commercial license

Aliases for INIP Gene

Aliases for INIP Gene

  • INTS3 And NABP Interacting Protein 2 3
  • Sensor Of Single-Strand DNA Complex Subunit C 2 3 4
  • C9orf80 3 4 6
  • Single-Stranded DNA-Binding Protein-Interacting Protein 1 3 4
  • Minute INTS3/HSSB-Associated Element 2 3
  • INTS3- And NABP-Interacting Protein 3 4
  • HSSB-Interacting Protein 1 2 3
  • Sensor Of SsDNA Subunit C 3 4
  • SSB-Interacting Protein 1 3 4
  • HSSBIP1 3 4
  • SOSS-C 3 4
  • SSBIP1 3 4
  • SOSSC 3 6
  • Chromosome 9 Open Reading Frame 80 2
  • SOSS Complex Subunit C 3
  • HSPC043 3
  • MISE 3

External Ids for INIP Gene

Previous Symbols for INIP Gene

  • C9orf80

Summaries for INIP Gene

Entrez Gene Summary for INIP Gene

  • SOSSC is a subunit of single-stranded DNA (ssDNA)-binding complexes involved in the maintenance of genome stability (Huang et al., 2009) [PubMed 19683501].[supplied by OMIM, Feb 2010]

GeneCards Summary for INIP Gene

INIP (INTS3 And NABP Interacting Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for INIP Gene

  • Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INIP Gene

Genomics for INIP Gene

Genomic Location for INIP Gene

Start:
112,683,926 bp from pter
End:
112,718,236 bp from pter
Size:
34,311 bases
Orientation:
Minus strand

Genomic View for INIP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for INIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INIP Gene

No data available for Regulatory Elements for INIP Gene

Proteins for INIP Gene

  • Protein details for INIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRY2-SOSSC_HUMAN
    Recommended name:
    SOSS complex subunit C
    Protein Accession:
    Q9NRY2
    Secondary Accessions:
    • Q5VWJ7
    • Q96E04
    • Q9P090

    Protein attributes for INIP Gene

    Size:
    104 amino acids
    Molecular mass:
    11425 Da
    Quaternary structure:
    • Component of the SOSS complex, composed of SOSS-B (SOSS-B1/NABP2 or SOSS-B2/NABP1), SOSS-A/INTS3 and SOSS-C/INIP. SOSS complexes containing SOSS-B1/NABP2 are more abundant than complexes containing SOSS-B2/NABP1. Interacts with INTS3; the interaction is direct.
    SequenceCaution:
    • Sequence=AAF28969.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH13097.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH71934.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for INIP Gene

    Alternative splice isoforms for INIP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for INIP Gene

Proteomics data for INIP Gene at MOPED

Post-translational modifications for INIP Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys28

Other Protein References for INIP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for INIP Gene

Domains for INIP Gene

Protein Domains for INIP Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9NRY2

UniProtKB/Swiss-Prot:

SOSSC_HUMAN
Family:
  • Belongs to the SOSS-C family.:
    • Q9NRY2
genes like me logo Genes that share domains with INIP: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for INIP Gene

Function for INIP Gene

Molecular function for INIP Gene

UniProtKB/Swiss-Prot Function: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.

Gene Ontology (GO) - Molecular Function for INIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19683501
genes like me logo Genes that share ontologies with INIP: view

Phenotypes for INIP Gene

GenomeRNAi human phenotypes for INIP:
genes like me logo Genes that share phenotypes with INIP: view

miRNA for INIP Gene

miRTarBase miRNAs that target INIP

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for INIP Gene

Localization for INIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for INIP Gene

Nucleus. Note=Localizes to nuclear foci following DNA damage.

Gene Ontology (GO) - Cellular Components for INIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19605351
GO:0005654 nucleoplasm IDA --
GO:0070876 SOSS complex IDA 18449195
genes like me logo Genes that share ontologies with INIP: view

No data available for Subcellular locations from COMPARTMENTS for INIP Gene

Pathways for INIP Gene

SuperPathways for INIP Gene

No Data Available

Gene Ontology (GO) - Biological Process for INIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IMP 19605351
GO:0006974 cellular response to DNA damage stimulus IMP 19683501
GO:0010212 response to ionizing radiation IMP 19605351
genes like me logo Genes that share ontologies with INIP: view

No data available for Pathways by source for INIP Gene

Transcripts for INIP Gene

Unigene Clusters for INIP Gene

INTS3 and NABP interacting protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for INIP Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g
SP1: -
SP2: - -
SP3: -
SP4: - - -
SP5: - - -
SP6: - - -
SP7: - - - -

Relevant External Links for INIP Gene

GeneLoc Exon Structure for
INIP
ECgene alternative splicing isoforms for
INIP

Expression for INIP Gene

mRNA expression in normal human tissues for INIP Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for INIP Gene

SOURCE GeneReport for Unigene cluster for INIP Gene Hs.658575

genes like me logo Genes that share expressions with INIP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for INIP Gene

Orthologs for INIP Gene

This gene was present in the common ancestor of chordates.

Orthologs for INIP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C9H9orf80 35
  • 100 (n)
  • 100 (a)
C9H9ORF80 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia INIP 35
  • 93.59 (n)
  • 98.08 (a)
INIP 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia INIP 35
  • 95.19 (n)
  • 99.04 (a)
INIP 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Inip 35
  • 90.38 (n)
  • 96.15 (a)
Inip 16
Inip 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 96 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia INIP 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Inip 35
  • 86.86 (n)
  • 95.19 (a)
chicken
(Gallus gallus)
Aves CZH9ORF80 35
  • 84.79 (n)
  • 93.2 (a)
CZH9ORF80 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia INIP 36
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia hspc043-A-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia inip 35
  • 75.69 (n)
  • 89.58 (a)
Str.10998 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10677 35
zebrafish
(Danio rerio)
Actinopterygii inip 35
  • 77.67 (n)
  • 87 (a)
inip 36
  • 82 (a)
OneToOne
zgc56259 35
Species with no ortholog for INIP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for INIP Gene

ENSEMBL:
Gene Tree for INIP (if available)
TreeFam:
Gene Tree for INIP (if available)

Paralogs for INIP Gene

Pseudogenes.org Pseudogenes for INIP Gene

genes like me logo Genes that share paralogs with INIP: view

No data available for Paralogs for INIP Gene

Variants for INIP Gene

Sequence variations from dbSNP and Humsavar for INIP Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs786960 -- 112,709,453(-) ATTCA(A/G)TAGTA intron-variant
rs786961 -- 112,709,066(+) TTCTC(C/T)TTCAC intron-variant
rs786963 -- 112,685,655(+) TCTCC(C/T)TAGAG utr-variant-3-prime
rs786964 -- 112,685,887(-) TTCAT(C/T)TTGAT utr-variant-3-prime
rs786965 -- 112,685,915(-) GTTTT(G/T)TTTAG utr-variant-3-prime

Relevant External Links for INIP Gene

HapMap Linkage Disequilibrium report
INIP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for INIP Gene

Disorders for INIP Gene

No disorders were found for INIP Gene.

No data available for UniProtKB/Swiss-Prot for INIP Gene

Publications for INIP Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. hSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response. (PMID: 19605351) Li Y. … Wang W. (J. Biol. Chem. 2009) 3 4
  5. SOSS complexes participate in the maintenance of genomic stability. (PMID: 19683501) Huang J. … Chen J. (Mol. Cell 2009) 3 4

Products for INIP Gene

Sources for INIP Gene

Back to Top

Content