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Aliases for INIP Gene

Aliases for INIP Gene

  • INTS3 And NABP Interacting Protein 2 3 5
  • Sensor Of Single-Strand DNA Complex Subunit C 2 3 4
  • Single-Stranded DNA-Binding Protein-Interacting Protein 1 3 4
  • Minute INTS3/HSSB-Associated Element 2 3
  • INTS3- And NABP-Interacting Protein 3 4
  • HSSB-Interacting Protein 1 2 3
  • Sensor Of SsDNA Subunit C 3 4
  • SSB-Interacting Protein 1 3 4
  • C9orf80 3 4
  • HSSBIP1 3 4
  • SOSS-C 3 4
  • SSBIP1 3 4
  • Chromosome 9 Open Reading Frame 80 2
  • HSPC043 3
  • SOSSC 3
  • MISE 3

External Ids for INIP Gene

Previous HGNC Symbols for INIP Gene

  • C9orf80

Previous GeneCards Identifiers for INIP Gene

  • GC09M115449

Summaries for INIP Gene

Entrez Gene Summary for INIP Gene

  • SOSSC is a subunit of single-stranded DNA (ssDNA)-binding complexes involved in the maintenance of genome stability (Huang et al., 2009) [PubMed 19683501].[supplied by OMIM, Feb 2010]

GeneCards Summary for INIP Gene

INIP (INTS3 And NABP Interacting Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for INIP Gene

  • Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INIP Gene

Genomics for INIP Gene

Regulatory Elements for INIP Gene

Enhancers for INIP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around INIP on UCSC Golden Path with GeneCards custom track

Promoters for INIP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around INIP on UCSC Golden Path with GeneCards custom track

Genomic Location for INIP Gene

Chromosome:
9
Start:
112,683,926 bp from pter
End:
112,718,236 bp from pter
Size:
34,311 bases
Orientation:
Minus strand

Genomic View for INIP Gene

Genes around INIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INIP Gene

Proteins for INIP Gene

  • Protein details for INIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRY2-SOSSC_HUMAN
    Recommended name:
    SOSS complex subunit C
    Protein Accession:
    Q9NRY2
    Secondary Accessions:
    • Q5VWJ7
    • Q96E04
    • Q9P090

    Protein attributes for INIP Gene

    Size:
    104 amino acids
    Molecular mass:
    11425 Da
    Quaternary structure:
    • Component of the SOSS complex, composed of SOSS-B (SOSS-B1/NABP2 or SOSS-B2/NABP1), SOSS-A/INTS3 and SOSS-C/INIP. SOSS complexes containing SOSS-B1/NABP2 are more abundant than complexes containing SOSS-B2/NABP1. Interacts with INTS3; the interaction is direct.
    SequenceCaution:
    • Sequence=AAF28969.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH13097.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH71934.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for INIP Gene

    Alternative splice isoforms for INIP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for INIP Gene

Proteomics data for INIP Gene at MOPED

Post-translational modifications for INIP Gene

  • Ubiquitination at Lys 28
  • Modification sites at PhosphoSitePlus

Other Protein References for INIP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for INIP Gene

Domains & Families for INIP Gene

Protein Domains for INIP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for INIP Gene

Graphical View of Domain Structure for InterPro Entry

Q9NRY2

UniProtKB/Swiss-Prot:

SOSSC_HUMAN :
  • Belongs to the SOSS-C family.
Family:
  • Belongs to the SOSS-C family.
genes like me logo Genes that share domains with INIP: view

No data available for Gene Families for INIP Gene

Function for INIP Gene

Molecular function for INIP Gene

UniProtKB/Swiss-Prot Function:
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.
genes like me logo Genes that share phenotypes with INIP: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for INIP Gene

Localization for INIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for INIP Gene

Nucleus. Note=Localizes to nuclear foci following DNA damage.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for INIP Gene COMPARTMENTS Subcellular localization image for INIP gene
Compartment Confidence
nucleus 5
mitochondrion 2

Gene Ontology (GO) - Cellular Components for INIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070876 SOSS complex IEA,IDA 18449195
genes like me logo Genes that share ontologies with INIP: view

Pathways & Interactions for INIP Gene

SuperPathways for INIP Gene

No Data Available

Gene Ontology (GO) - Biological Process for INIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010212 response to ionizing radiation IMP 19605351
genes like me logo Genes that share ontologies with INIP: view

No data available for Pathways by source and SIGNOR curated interactions for INIP Gene

Drugs & Compounds for INIP Gene

No Compound Related Data Available

Transcripts for INIP Gene

Unigene Clusters for INIP Gene

INTS3 and NABP interacting protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for INIP Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g
SP1: -
SP2: - -
SP3: -
SP4: - - -
SP5: - - -
SP6: - - -
SP7: - - - -

Relevant External Links for INIP Gene

GeneLoc Exon Structure for
INIP
ECgene alternative splicing isoforms for
INIP

Expression for INIP Gene

mRNA expression in normal human tissues for INIP Gene

Protein differential expression in normal tissues from HIPED for INIP Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.2), Monocytes (13.5), Spleen (7.3), and Pancreas (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for INIP Gene



SOURCE GeneReport for Unigene cluster for INIP Gene Hs.658575

genes like me logo Genes that share expression patterns with INIP: view

Protein tissue co-expression partners for INIP Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for INIP Gene

Orthologs for INIP Gene

This gene was present in the common ancestor of chordates.

Orthologs for INIP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia INIP 35
  • 93.59 (n)
  • 98.08 (a)
INIP 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia INIP 35
  • 95.19 (n)
  • 99.04 (a)
INIP 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Inip 35
  • 90.38 (n)
  • 96.15 (a)
Inip 16
Inip 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C9H9orf80 35
  • 100 (n)
  • 100 (a)
C9H9ORF80 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Inip 35
  • 86.86 (n)
  • 95.19 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 96 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia INIP 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves CZH9ORF80 35
  • 84.79 (n)
  • 93.2 (a)
CZH9ORF80 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia INIP 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia inip 35
  • 75.69 (n)
  • 89.58 (a)
Str.10998 35
African clawed frog
(Xenopus laevis)
Amphibia hspc043-A-prov 35
zebrafish
(Danio rerio)
Actinopterygii inip 35
  • 77.67 (n)
  • 87 (a)
zgc56259 35
inip 36
  • 82 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10677 35
Species with no ortholog for INIP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for INIP Gene

ENSEMBL:
Gene Tree for INIP (if available)
TreeFam:
Gene Tree for INIP (if available)

Paralogs for INIP Gene

Pseudogenes.org Pseudogenes for INIP Gene

genes like me logo Genes that share paralogs with INIP: view

No data available for Paralogs for INIP Gene

Variants for INIP Gene

Sequence variations from dbSNP and Humsavar for INIP Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs786960 -- 112,709,453(-) ATTCA(A/G)TAGTA intron-variant
rs786961 -- 112,709,066(+) TTCTC(C/T)TTCAC intron-variant
rs786963 -- 112,685,655(+) TCTCC(C/T)TAGAG utr-variant-3-prime
rs786964 -- 112,685,887(-) TTCAT(C/T)TTGAT utr-variant-3-prime
rs786965 -- 112,685,915(-) GTTTT(G/T)TTTAG utr-variant-3-prime

Variation tolerance for INIP Gene

Residual Variation Intolerance Score: 55% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.04; 0.80% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for INIP Gene

Disorders for INIP Gene

Relevant External Links for INIP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
INIP

No disorders were found for INIP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for INIP Gene

Publications for INIP Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for INIP Gene

Sources for INIP Gene

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