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Aliases for INIP Gene

Aliases for INIP Gene

  • INTS3 And NABP Interacting Protein 2 3 5
  • Sensor Of Single-Strand DNA Complex Subunit C 2 3 4
  • Single-Stranded DNA-Binding Protein-Interacting Protein 1 3 4
  • Minute INTS3/HSSB-Associated Element 2 3
  • HSSB-Interacting Protein 1 2 3
  • Sensor Of SsDNA Subunit C 3 4
  • SSB-Interacting Protein 1 3 4
  • C9orf80 3 4
  • HSSBIP1 3 4
  • SSBIP1 3 4
  • INTS3- And NABP-Interacting Protein 4
  • Chromosome 9 Open Reading Frame 80 2
  • SOSS Complex Subunit C 3
  • HSPC043 3
  • SOSS-C 4
  • SOSSC 3
  • MISE 3

External Ids for INIP Gene

Previous HGNC Symbols for INIP Gene

  • C9orf80

Previous GeneCards Identifiers for INIP Gene

  • GC09M115449

Summaries for INIP Gene

Entrez Gene Summary for INIP Gene

  • The protein encoded by this gene is a subunit of single-stranded DNA binding complexes that are important for maintaining genome stability. These complexes are involved in G2/M checkpoint control and homologous recombination repair. [provided by RefSeq, Jul 2016]

GeneCards Summary for INIP Gene

INIP (INTS3 And NABP Interacting Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for INIP Gene

  • Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INIP Gene

Genomics for INIP Gene

Regulatory Elements for INIP Gene

Enhancers for INIP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F112747 1.1 FANTOM5 ENCODE 12 -29.0 -29011 0.4 SOX13 GATAD2A SOX5 HMG20B SAP130 CEBPB CEBPG ZNF644 MIER3 RBAK INIP SNX30 KIAA1958 ZFP37 ZNF883
GH09F112793 1.1 Ensembl ENCODE 11.3 -75.2 -75165 0.4 CTCF ZNF687 ZNF654 SAP130 ARID4B MAX TRIM22 REST RAD21 KLF16 ENSG00000226609 SNX30 INIP KIAA1958 C9orf147 PIR49803
GH09F112788 1.2 Ensembl ENCODE 11.3 -71.5 -71466 1.8 CTCF RAD51 IKZF1 USF2 ENSG00000226609 SNX30 INIP C9orf147 KIAA1958 SLC46A2 PIR49803
GH09F112771 0.6 Ensembl ENCODE 11.2 -53.9 -53865 1.4 ZNF318 SCRT2 NFE2 KDM1A SPI1 ENSG00000226609 SNX30 INIP PIR49803
GH09F112753 0.6 Ensembl ENCODE 11 -37.7 -37664 5.4 KLF1 ZKSCAN1 ZFHX2 GATA3 CTBP1 POLR2A ZNF239 PRDM10 FOS MAFK INIP ZFP37 SLC46A2 SNX30 ENSG00000226609 ENSG00000271631 PIR49803
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around INIP on UCSC Golden Path with GeneCards custom track

Promoters for INIP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001311881 336 1801 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF143 KLF13

Genomic Location for INIP Gene

Chromosome:
9
Start:
112,683,926 bp from pter
End:
112,718,236 bp from pter
Size:
34,311 bases
Orientation:
Minus strand

Genomic View for INIP Gene

Genes around INIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INIP Gene

Proteins for INIP Gene

  • Protein details for INIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRY2-SOSSC_HUMAN
    Recommended name:
    SOSS complex subunit C
    Protein Accession:
    Q9NRY2
    Secondary Accessions:
    • Q5VWJ7
    • Q96E04
    • Q9P090

    Protein attributes for INIP Gene

    Size:
    104 amino acids
    Molecular mass:
    11425 Da
    Quaternary structure:
    • Component of the SOSS complex, composed of SOSS-B (SOSS-B1/NABP2 or SOSS-B2/NABP1), SOSS-A/INTS3 and SOSS-C/INIP. SOSS complexes containing SOSS-B1/NABP2 are more abundant than complexes containing SOSS-B2/NABP1. Interacts with INTS3; the interaction is direct.
    SequenceCaution:
    • Sequence=AAF28969.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH13097.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH71934.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for INIP Gene

    Alternative splice isoforms for INIP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for INIP Gene

Post-translational modifications for INIP Gene

  • Ubiquitination at Lys 28
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for INIP Gene

Domains & Families for INIP Gene

Protein Domains for INIP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for INIP Gene

Graphical View of Domain Structure for InterPro Entry

Q9NRY2

UniProtKB/Swiss-Prot:

SOSSC_HUMAN :
  • Belongs to the SOSS-C family.
Family:
  • Belongs to the SOSS-C family.
genes like me logo Genes that share domains with INIP: view

No data available for Gene Families for INIP Gene

Function for INIP Gene

Molecular function for INIP Gene

UniProtKB/Swiss-Prot Function:
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.

Gene Ontology (GO) - Molecular Function for INIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19683501
genes like me logo Genes that share ontologies with INIP: view
genes like me logo Genes that share phenotypes with INIP: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for INIP Gene

Localization for INIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for INIP Gene

Nucleus. Note=Localizes to nuclear foci following DNA damage.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for INIP Gene COMPARTMENTS Subcellular localization image for INIP gene
Compartment Confidence
nucleus 5
mitochondrion 2

Gene Ontology (GO) - Cellular Components for INIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 19605351
GO:0005654 nucleoplasm IDA --
GO:0070876 SOSS complex IEA,IDA 18449195
genes like me logo Genes that share ontologies with INIP: view

Pathways & Interactions for INIP Gene

SuperPathways for INIP Gene

No Data Available

Gene Ontology (GO) - Biological Process for INIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA,IMP 19605351
GO:0006974 cellular response to DNA damage stimulus IEA,IMP 19683501
GO:0010212 response to ionizing radiation IMP 19605351
genes like me logo Genes that share ontologies with INIP: view

No data available for Pathways by source and SIGNOR curated interactions for INIP Gene

Transcripts for INIP Gene

Unigene Clusters for INIP Gene

INTS3 and NABP interacting protein:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for INIP Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g
SP1: -
SP2: - -
SP3: -
SP4: - - -
SP5: - - -
SP6: - - -
SP7: - - - -

Relevant External Links for INIP Gene

GeneLoc Exon Structure for
INIP
ECgene alternative splicing isoforms for
INIP

Expression for INIP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for INIP Gene

Protein differential expression in normal tissues from HIPED for INIP Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.2), Monocytes (13.5), Spleen (7.3), and Pancreas (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for INIP Gene



Protein tissue co-expression partners for INIP Gene

NURSA nuclear receptor signaling pathways regulating expression of INIP Gene:

INIP

SOURCE GeneReport for Unigene cluster for INIP Gene:

Hs.658575
genes like me logo Genes that share expression patterns with INIP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for INIP Gene

Orthologs for INIP Gene

This gene was present in the common ancestor of chordates.

Orthologs for INIP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C9H9orf80 34
  • 100 (n)
C9H9ORF80 35
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 96 (a)
OneToMany
-- 35
  • 91 (a)
OneToMany
dog
(Canis familiaris)
Mammalia INIP 34 35
  • 95.19 (n)
cow
(Bos Taurus)
Mammalia INIP 34 35
  • 93.59 (n)
mouse
(Mus musculus)
Mammalia Inip 34 16 35
  • 90.38 (n)
rat
(Rattus norvegicus)
Mammalia Inip 34
  • 86.86 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia INIP 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves CZH9ORF80 34 35
  • 84.79 (n)
lizard
(Anolis carolinensis)
Reptilia INIP 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia inip 34
  • 75.69 (n)
Str.10998 34
African clawed frog
(Xenopus laevis)
Amphibia hspc043-A-prov 34
zebrafish
(Danio rerio)
Actinopterygii inip 34 35
  • 77.67 (n)
zgc56259 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10677 34
Species where no ortholog for INIP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for INIP Gene

ENSEMBL:
Gene Tree for INIP (if available)
TreeFam:
Gene Tree for INIP (if available)

Paralogs for INIP Gene

Pseudogenes.org Pseudogenes for INIP Gene

genes like me logo Genes that share paralogs with INIP: view

No data available for Paralogs for INIP Gene

Variants for INIP Gene

Sequence variations from dbSNP and Humsavar for INIP Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10120573 -- 112,711,571(+) ATCTT(C/T)CCAAA intron-variant
rs10513168 -- 112,714,360(+) CAGAA(C/T)GGAAA intron-variant
rs10759583 -- 112,690,377(+) AGCTA(C/T)GTGGG intron-variant
rs10817370 -- 112,699,767(+) TCCAT(G/T)AGAAA intron-variant
rs10817371 -- 112,707,474(+) TTTTG(A/C)CTCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for INIP Gene

Variant ID Type Subtype PubMed ID
dgv262e55 CNV gain 17911159
dgv7701n100 CNV gain 25217958
esv2759710 CNV gain 17122850
esv2761275 CNV gain 21179565
esv3621517 CNV gain 21293372
esv3621518 CNV gain 21293372
nsv415734 CNV deletion 16902084
nsv442163 CNV gain 18776908
nsv471317 CNV gain 18288195
nsv515121 CNV gain 21397061
nsv515899 CNV gain+loss 19592680
nsv615198 CNV gain 21841781

Variation tolerance for INIP Gene

Residual Variation Intolerance Score: 55% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.04; 0.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for INIP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
INIP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INIP Gene

Disorders for INIP Gene

Relevant External Links for INIP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
INIP

No disorders were found for INIP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for INIP Gene

Publications for INIP Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4 64
  2. hSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response. (PMID: 19605351) Li Y. … Wang W. (J. Biol. Chem. 2009) 3 4 64
  3. SOSS complexes participate in the maintenance of genomic stability. (PMID: 19683501) Huang J. … Chen J. (Mol. Cell 2009) 3 4 64
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for INIP Gene

Sources for INIP Gene

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