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INHBE Gene

protein-coding   GIFtS: 53
GCID: GC12P057849

Inhibin, Beta E

  See INHBE-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Inhibin, Beta E1 2
Activin Beta-E Chain2 3
Activin Beta E2
Inhibin Beta E Chain2

External Ids:    HGNC: 240291   Entrez Gene: 837292   Ensembl: ENSG000001392697   OMIM: 6120315   UniProtKB: P581663   

Export aliases for INHBE gene to outside databases

Previous GC identifers: GC12P057992 GC12P057565 GC12P056135 GC12P054886


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for INHBE Gene:
INHBE is a member of the activin beta family (see INHBA; MIM 147290) that plays a role in pancreatic exocrine cell
growth and proliferation (Hashimoto et al., 2006 (PubMed 16426570)).(supplied by OMIM, May 2008)

GeneCards Summary for INHBE Gene:
INHBE (inhibin, beta E) is a protein-coding gene. Diseases associated with INHBE include endometrial adenocarcinoma, and testicular germ cell tumor. GO annotations related to this gene include growth factor activity and hormone activity. An important paralog of this gene is GDF11.

UniProtKB/Swiss-Prot: INHBE_HUMAN, P58166
Function: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary
gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and
pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid
differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on
their subunit composition. Inhibins appear to oppose the functions of activins




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the INHBE gene promoter:
         NF-1   Sp1   p53   c-Myb   Nkx2-5   STAT5A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidINHBE promoter sequence
   Search Chromatin IP Primers for INHBE

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat INHBE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.3   Ensembl cytogenetic band:  12q13.3   HGNC cytogenetic band: 12q13.2

INHBE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INHBE gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P057849:  view genomic region     (about GC identifiers)

Start:
57,846,106 bp from pter      End:
57,853,063 bp from pter
Size:
6,958 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: INHBE_HUMAN, P58166 (See protein sequence)
Recommended Name: Inhibin beta E chain precursor  
Size: 350 amino acids; 38561 Da
Subunit: Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more
disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers
of beta subunits only (By similarity)

Explore the universe of human proteins at neXtProt for INHBE: NX_P58166

Explore proteomics data for INHBE at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn198

  • See INHBE Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_113667.1  
    ENSEMBL proteins: 
     ENSP00000450212   ENSP00000266646  
    Reactome Protein details: P58166

    INHBE Human Recombinant Protein Products:

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    Novus Biologicals INHBE Protein
    Novus Biologicals INHBE Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for INHBE 

    INHBE Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for INHBE
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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for INHBE 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR001111 TGF-b_N
     IPR015615 TGF-beta-rel
     IPR001318 Inhibin_betaC
     IPR001839 TGF-b_C
     IPR017948 TGFb_CS

    Graphical View of Domain Structure for InterPro Entry P58166

    ProtoNet protein and cluster: P58166

    2 Blocks protein domains:
    IPB001839 Transforming growth factor beta (TGFb)
    IPB002400 Growth factor cystine knot superfamily signature


    UniProtKB/Swiss-Prot: INHBE_HUMAN, P58166
    Similarity: Belongs to the TGF-beta family


    Find genes that share domains with INHBE           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: INHBE_HUMAN, P58166
    Function: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary
    gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and
    pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid
    differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on
    their subunit composition. Inhibins appear to oppose the functions of activins

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005179hormone activity IEA--
    GO:0008083growth factor activity IEA--
         
    Find genes that share ontologies with INHBE           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 3 alleles(MGI details for Inhbe):
     normal 

    Find genes that share phenotypes with INHBE           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for INHBE: Inhbetm1Zuk Inhbe/InhbcInhbe/tm1Sjl Inhbetm2Zuk

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for INHBE
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for INHBE

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for INHBE
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for INHBE

    miRNA
    Products:
        
    miRTarBase miRNAs that target INHBE:
    hsa-mir-98-5p (MIRT027405), hsa-mir-335-5p (MIRT016770)

    Block miRNA regulation of human, mouse, rat INHBE using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate INHBE (see all 12):
    hsa-miR-30c-2* hsa-miR-875-3p hsa-miR-3194-5p hsa-miR-548aa hsa-miR-1224-5p hsa-miR-3171 hsa-miR-548l hsa-miR-30c-1*
    SwitchGear 3'UTR luciferase reporter plasmidINHBE 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for INHBE
    Predesigned siRNA for gene silencing in human, mouse, rat INHBE

    Gene Editing
    Products:
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    Clone
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    OriGene ORF clones in mouse, rat for INHBE
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: INHBE (NM_031479)
    Sino Biological Human cDNA Clone for INHBE
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INHBE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INHBE

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for INHBE
    Browse ESI BIO Cell Lines and PureStem Progenitors for INHBE 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INHBE


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    INHBE_HUMAN, P58166: Secreted (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    cytosol1
    endoplasmic reticulum1
    golgi apparatus1
    lysosome1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    Find genes that share ontologies with INHBE           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for INHBE About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide hormone metabolism
    Peptide hormone metabolism0.30
    Peptide hormone biosynthesis0.00
    Glycoprotein hormones0.00
    2PEDF Induced Signaling
    Cytokine-cytokine receptor interaction0.43
    3Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    4TGF-beta Signaling Pathway (sino)
    TGF-beta Signaling Pathway
    5TGF-beta signaling pathway (KEGG)
    TGF-beta signaling pathway


    Find genes that share SuperPaths with INHBE           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Sino Biological Pathway for INHBE
        TGF-beta Signaling Pathway

    1 Reactome Pathway for INHBE
        Glycoprotein hormones


    2 Kegg Pathways  (Kegg details for INHBE):
        Cytokine-cytokine receptor interaction
    TGF-beta signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including INHBE: 
              Fibrosis in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for INHBE

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for INHBE (P581663 ENSP000002666464) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FSTP198833, ENSP000002567594I2D: score=2 STRING: ENSP00000256759
    PTENP604843, ENSP000003610214I2D: score=1 STRING: ENSP00000361021
    CGAENSP000003585954STRING: ENSP00000358595
    FSHBENSP000002541224STRING: ENSP00000254122
    INHAENSP000002437864STRING: ENSP00000243786
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0040007growth IEA--

    Find genes that share ontologies with INHBE           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for INHBE



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for INHBE gene: 
    NM_031479.3  

    Unigene Cluster for INHBE:

    Inhibin, beta E
    Hs.632713  [show with all ESTs]
    Unigene Representative Sequence: AF412024
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000551553 ENST00000547970 ENST00000266646(uc001snw.3) ENST00000553033

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat INHBE using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate INHBE (see all 12):
    hsa-miR-30c-2* hsa-miR-875-3p hsa-miR-3194-5p hsa-miR-548aa hsa-miR-1224-5p hsa-miR-3171 hsa-miR-548l hsa-miR-30c-1*
    SwitchGear 3'UTR luciferase reporter plasmidINHBE 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for INHBE
    Predesigned siRNA for gene silencing in human, mouse, rat INHBE
    Clone
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    OriGene clones in human, mouse for INHBE (see all 7)
    OriGene ORF clones in mouse, rat for INHBE
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: INHBE (NM_031479)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INHBE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INHBE
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for INHBE
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat INHBE
      QuantiTect SYBR Green Assays in human, mouse, rat INHBE
      QuantiFast Probe-based Assays in human, mouse, rat INHBE

    Additional mRNA sequence: 

    AF412024.1 AK075285.1 AK308647.1 BC005161.2 

    2 DOTS entries:

    DT.100019870  DT.40199098 

    Selected AceView cDNA sequences (see all 40):

    NM_031479 AA113781 AK075285 BC005161 BU632022 BQ772988 BM471716 BE294509 
    BX331898 BF309695 BG826538 AL519988 BF205858 BE296212 BE297378 AF412024 
    BE294783 BF204851 AL519989 BE298480 AA112414 BG826333 BF305560 BF305618 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    INHBE expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGATTACATC
    INHBE Expression
    About this image


    INHBE expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Line H9 (Naive)
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     
     Liver (Hepatobiliary System)
    INHBE Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    INHBE Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632713
        Pathway & Disease-focused RT2 Profiler PCR Arrays including INHBE: 
              Fibrosis in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for INHBE
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat INHBE
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    QuantiFast Probe-based Assays in human, mouse, rat INHBE
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INHBE

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for INHBE gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Inhbe1 , 5 inhibin beta E1, 5 83.67(n)1
    82.81(a)1
      10 (74.50 cM)5
    163261  NM_008382.21  NP_032408.21 
     1273494025 
    lizard
    (Anolis carolinensis)
    Reptilia INHBE6
    inhibin, beta E
    41(a)
    1 ↔ 1
    GL343212.1(900694-905249)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia inhbc1 inhibin, beta C 50.11(n)
    43.46(a)
      100494560  XM_002939428.2  XP_002939474.1 
    zebrafish
    (Danio rerio)
    Actinopterygii INHBE6
    inhibin, beta E
    34(a)
    1 ↔ 1
    1(30609327-30615423) ENSDARG00000040780
    fruit fly
    (Drosophila melanogaster)
    Insecta Actbeta6
    Activin-beta
    9(a)
    1 → many
    4(1097946-1105418)


    ENSEMBL Gene Tree for INHBE (if available)
    TreeFam Gene Tree for INHBE (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for INHBE gene
    GDF112  MSTN2  TGFB22  INHBB2  TGFB32  INHBC2  INHBA2  TGFB12  
    3 SIMAP similar genes for INHBE using alignment to 2 protein entries:     INHBE_HUMAN (see all proteins):
    DKFZp686A06204    INHBC    INHBB

    Find genes that share paralogs with INHBE           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for INHBE (see all 121)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0361984
    A breast cancer sample4--see VAR_0361982 R T mis40--------
    VAR_0361994
    A breast cancer sample4--see VAR_0361992 Q H mis40--------
    rs1869156871,2
    --57847117(+) GTGGAA/GGGGTC 1 -- us2k10--------
    rs343840301,2
    C--57847127(+) CCCCC-/CATTTA 1 -- us2k10--------
    rs1891870551,2
    C--57847182(+) TAATCC/TTAGCG 1 -- us2k10--------
    rs1162930691,2
    F--57847226(+) CCCAGG/AAGCTT 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1457104301,2
    --57847295(+) TAGCCG/TGTGTG 1 -- us2k10--------
    rs1472968951,2
    --57847389(+) CAGGAG/TGTCAA 1 -- us2k10--------
    rs1819480811,2
    --57847819(+) TGGTCA/CGGAGG 1 -- us2k10--------
    rs1398422051,2
    --57847924(+) GGGTGA/GTGCGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for INHBE (57846106 - 57853063 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for INHBE:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv469411CNV Loss19166990
    nsv899119CNV Loss21882294
    nsv899117CNV Loss21882294
    nsv899118CNV Gain21882294
    nsv428283CNV Gain18775914
    dgv513e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing INHBE
    DNA2.0 Custom Variant and Variant Library Synthesis for INHBE

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612031    OMIM disorders: --

    3 diseases for INHBE:    
    About MalaCards
    endometrial adenocarcinoma    testicular germ cell tumor    germ cell tumors

    1 disease from the University of Copenhagen DISEASES database for INHBE:
    Wolfram syndrome

    Find genes that share disorders with INHBE           About GenesLikeMe

    Genetic Association Database (GAD): INHBE
    Human Genome Epidemiology (HuGE) Navigator: INHBE (2 documents)

    Export disorders for INHBE gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for INHBE gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with INHBE)
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    1. cDNA cloning and expression of human activin betaE subunit. (PubMed id 12242034)1, 2, 3, 9 Hashimoto O....Hasegawa Y. (Mol. Cell. Endocrinol. 2002)
    2. Genetic variation in the inhibin pathway and risk of testicular germ cell tumors. (PubMed id 18413775)1, 4, 9 Purdue M.P....McGlynn K.A. (Cancer Res. 2008)
    3. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Inhibin/activin-betaE subunit in normal and malignant human cervical tissue and cervical cancer cell lines. (PubMed id 20033758)1, 9 Bergauer F....Mylonas I. (J. Mol. Histol. 2009)
    7. Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. (PubMed id 23263486)1 KAPttgen A....Gieger C. (Nat. Genet. 2013)
    8. Inhibin/activin-betaC and -betaE subunits in the Ishikawa human endometrial adenocarcinoma cell line. (PubMed id 20012305)1 Kimmich T....Mylonas I. (Arch. Gynecol. Obstet. 2010)
    9. Evidence of inhibin/activin subunit betaC and betaE synthesis in normal human endometrial tissue. (PubMed id 21092084)1 Mylonas I....Kupka M.S. (amp 2010)
    10. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (J. Proteome Res. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 83729 HGNC: 24029 AceView: INHBE Ensembl:ENSG00000139269 euGenes: HUgn83729
    ECgene: INHBE Kegg: 83729 H-InvDB: INHBE

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for INHBE Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for INHBE gene:
    Search GeneIP for patents involving INHBE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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