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Aliases for INHBE Gene

Aliases for INHBE Gene

  • Inhibin Beta E Subunit 2 3 5
  • Activin Beta-E Chain 4
  • Inhibin, Beta E 2

External Ids for INHBE Gene

Previous GeneCards Identifiers for INHBE Gene

  • GC12P057992
  • GC12P057565
  • GC12P056135
  • GC12P057849
  • GC12P054886

Summaries for INHBE Gene

Entrez Gene Summary for INHBE Gene

  • This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate an inhibin beta subunit. Inhibins have been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion. This gene may be upregulated under conditions of endoplasmic reticulum stress, and this protein may inhibit cellular proliferation and growth in pancreas and liver. [provided by RefSeq, Sep 2016]

GeneCards Summary for INHBE Gene

INHBE (Inhibin Beta E Subunit) is a Protein Coding gene. Among its related pathways are TGF-beta signaling pathway (KEGG) and Signaling pathways regulating pluripotency of stem cells. GO annotations related to this gene include cytokine activity and hormone activity. An important paralog of this gene is INHBC.

UniProtKB/Swiss-Prot for INHBE Gene

  • Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INHBE Gene

Genomics for INHBE Gene

Regulatory Elements for INHBE Gene

Enhancers for INHBE Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G057242 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -209.1 -209129 2.0 PKNOX1 ATF1 SIN3A ZNF2 ZNF48 GLIS2 GATA2 ZNF143 KLF7 ZNF548 NEMP1 ARHGAP9 BAZ2A CTDSP2 NXPH4 RN7SL809P RNU6-343P STAT2 INHBE RBMS2
GH12G057339 1.3 Ensembl ENCODE 11.8 -111.1 -111074 3.7 ATF1 CREB3L1 ARID4B GLI4 ZNF2 GLIS2 KLF7 SP3 TSHZ1 REST INHBE RNU6-879P GLI1 LRP1 TSFM ARHGAP9 ENSG00000224713 R3HDM2 DCTN2 PTGES3
GH12G057238 1.4 ENCODE dbSUPER 10.4 -212.6 -212636 4.4 HDGF PKNOX1 CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF2 ZNF143 FOS STAT6 NXPH4 INHBE MYO1A LRP1 ZBTB39 MARCH9 CNPY2 MARS ARHGAP9
GH12G057279 1.3 Ensembl ENCODE 11 -172.0 -172002 2.1 HDGF PKNOX1 ATF1 ARID4B SIN3A GATA2 ZNF143 ZNF207 FOS ZHX2 SHMT2 NXPH4 INHBE GLI1 ARHGEF25 PIR33837 STAC3
GH12G057245 1.2 ENCODE dbSUPER 10.4 -207.1 -207091 0.2 PKNOX1 ZNF2 YY2 REST ZNF662 ZNF491 ZNF518A ZNF610 GLIS1 ZNF624 ENSG00000257740 ANKRD52 LOC283387 NAB2 TSPAN31 NXPH4 ZBTB39 NEMP1 ARHGEF25 B4GALNT1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around INHBE on UCSC Golden Path with GeneCards custom track

Genomic Location for INHBE Gene

Chromosome:
12
Start:
57,452,323 bp from pter
End:
57,459,280 bp from pter
Size:
6,958 bases
Orientation:
Plus strand

Genomic View for INHBE Gene

Genes around INHBE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INHBE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INHBE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INHBE Gene

Proteins for INHBE Gene

  • Protein details for INHBE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P58166-INHBE_HUMAN
    Recommended name:
    Inhibin beta E chain
    Protein Accession:
    P58166

    Protein attributes for INHBE Gene

    Size:
    350 amino acids
    Molecular mass:
    38561 Da
    Quaternary structure:
    • Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only (By similarity).

neXtProt entry for INHBE Gene

Post-translational modifications for INHBE Gene

  • Glycosylation at isoforms=198
  • Modification sites at PhosphoSitePlus

Other Protein References for INHBE Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for INHBE Gene

Domains & Families for INHBE Gene

Suggested Antigen Peptide Sequences for INHBE Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P58166

UniProtKB/Swiss-Prot:

INHBE_HUMAN :
  • Belongs to the TGF-beta family.
Family:
  • Belongs to the TGF-beta family.
genes like me logo Genes that share domains with INHBE: view

No data available for Gene Families for INHBE Gene

Function for INHBE Gene

Molecular function for INHBE Gene

UniProtKB/Swiss-Prot Function:
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

Gene Ontology (GO) - Molecular Function for INHBE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005160 transforming growth factor beta receptor binding IBA --
GO:0005179 hormone activity IEA --
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with INHBE: view
genes like me logo Genes that share phenotypes with INHBE: view

Animal Models for INHBE Gene

MGI Knock Outs for INHBE:

Animal Model Products

  • Taconic Biosciences Mouse Models for INHBE

miRNA for INHBE Gene

miRTarBase miRNAs that target INHBE

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for INHBE Gene

Localization for INHBE Gene

Subcellular locations from UniProtKB/Swiss-Prot for INHBE Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for INHBE gene
Compartment Confidence
extracellular 4
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for INHBE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with INHBE: view

Pathways & Interactions for INHBE Gene

genes like me logo Genes that share pathways with INHBE: view

Gene Ontology (GO) - Biological Process for INHBE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IBA --
GO:0042981 regulation of apoptotic process IBA --
GO:0043408 regulation of MAPK cascade IBA --
GO:0048468 cell development IBA --
GO:0060395 SMAD protein signal transduction IBA --
genes like me logo Genes that share ontologies with INHBE: view

No data available for SIGNOR curated interactions for INHBE Gene

Drugs & Compounds for INHBE Gene

No Compound Related Data Available

Transcripts for INHBE Gene

Unigene Clusters for INHBE Gene

Inhibin, beta E:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for INHBE Gene

No ASD Table

Relevant External Links for INHBE Gene

GeneLoc Exon Structure for
INHBE
ECgene alternative splicing isoforms for
INHBE

Expression for INHBE Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for INHBE Gene

mRNA differential expression in normal tissues according to GTEx for INHBE Gene

This gene is overexpressed in Liver (x48.0).

Protein differential expression in normal tissues from HIPED for INHBE Gene

This gene is overexpressed in Heart (28.2), Plasma (13.6), Liver (10.0), and Adrenal (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for INHBE Gene



Protein tissue co-expression partners for INHBE Gene

NURSA nuclear receptor signaling pathways regulating expression of INHBE Gene:

INHBE

SOURCE GeneReport for Unigene cluster for INHBE Gene:

Hs.632713

Evidence on tissue expression from TISSUES for INHBE Gene

  • Liver(4.4)
  • Muscle(4.3)
genes like me logo Genes that share expression patterns with INHBE: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for INHBE Gene

Orthologs for INHBE Gene

This gene was present in the common ancestor of animals.

Orthologs for INHBE Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INHBE 34 35
  • 99.43 (n)
cow
(Bos Taurus)
Mammalia INHBE 34 35
  • 85.43 (n)
mouse
(Mus musculus)
Mammalia Inhbe 34 16 35
  • 83.67 (n)
rat
(Rattus norvegicus)
Mammalia Inhbe 34
  • 81.85 (n)
dog
(Canis familiaris)
Mammalia INHBE 34 35
  • 81.24 (n)
lizard
(Anolis carolinensis)
Reptilia INHBE 35
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia inhbc 34
  • 50.11 (n)
zebrafish
(Danio rerio)
Actinopterygii INHBE 35
  • 34 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Actbeta 35
  • 9 (a)
OneToMany
Species where no ortholog for INHBE was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for INHBE Gene

ENSEMBL:
Gene Tree for INHBE (if available)
TreeFam:
Gene Tree for INHBE (if available)

Paralogs for INHBE Gene

Paralogs for INHBE Gene

(3) SIMAP similar genes for INHBE Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with INHBE: view

Variants for INHBE Gene

Sequence variations from dbSNP and Humsavar for INHBE Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_036198 A breast cancer sample
VAR_036199 A breast cancer sample
rs1001654958 -- 57,455,059(+) AGCAT(A/G)TGAAA upstream-variant-2KB
rs1002404220 -- 57,455,676(+) GCTAG(C/G)CAAGC reference, missense
rs1003400802 -- 57,454,220(+) AAGAC(C/G)AGCCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for INHBE Gene

Variant ID Type Subtype PubMed ID
dgv2651n54 CNV loss 21841781
esv2759901 CNV gain 17122850
nsv428283 CNV gain 18775914
nsv469411 CNV loss 19166990
nsv482992 CNV gain+loss 15286789

Variation tolerance for INHBE Gene

Residual Variation Intolerance Score: 44.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.43; 28.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for INHBE Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
INHBE

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INHBE Gene

Disorders for INHBE Gene

Relevant External Links for INHBE

Genetic Association Database (GAD)
INHBE
Human Genome Epidemiology (HuGE) Navigator
INHBE
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
INHBE

No disorders were found for INHBE Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for INHBE Gene

Publications for INHBE Gene

  1. cDNA cloning and expression of human activin betaE subunit. (PMID: 12242034) Hashimoto O. … Hasegawa Y. (Mol. Cell. Endocrinol. 2002) 2 3 4 22 64
  2. Genetic variation in the inhibin pathway and risk of testicular germ cell tumors. (PMID: 18413775) Purdue M.P. … McGlynn K.A. (Cancer Res. 2008) 3 22 46 64
  3. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C. … Hunter D.J. (Hum. Genet. 2010) 3 46 64
  4. Inhibin/activin-betaE subunit in normal and malignant human cervical tissue and cervical cancer cell lines. (PMID: 20033758) Bergauer F. … Mylonas I. (J. Mol. Histol. 2009) 3 22 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for INHBE Gene

Sources for INHBE Gene

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