External Ids for INHBE Gene
INHBE is a member of the activin beta family (see INHBA; MIM 147290) that plays a role in pancreatic exocrine cell growth and proliferation (Hashimoto et al., 2006 [PubMed 16426570]).[supplied by OMIM, May 2008]
GeneCards Summary for INHBE Gene
INHBE (Inhibin, Beta E) is a Protein Coding gene. Diseases associated with INHBE include endometrial adenocarcinoma and testicular germ cell tumor. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and TGF-beta Signaling Pathway (sino). GO annotations related to this gene include growth factor activity and hormone activity. An important paralog of this gene is INHBB.
UniProtKB/Swiss-Prot for INHBE Gene
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins