External Ids for INHBC Gene
Previous GeneCards Identifiers for INHBC Gene
This gene encodes the beta C chain of inhibin, a member of the TGF-beta superfamily. This subunit forms heterodimers with beta A and beta B subunits. Inhibins and activins, also members of the TGF-beta superfamily, are hormones with opposing actions and are involved in hypothalamic, pituitary, and gonadal hormone secretion, as well as growth and differentiation of various cell types. [provided by RefSeq, Jul 2008]
GeneCards Summary for INHBC Gene
INHBC (Inhibin, Beta C) is a Protein Coding gene. Diseases associated with INHBC include gastric diffuse adenocarcinoma and endometrial adenocarcinoma. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and TGF-beta Signaling Pathway (sino). GO annotations related to this gene include growth factor activity and transforming growth factor beta receptor binding. An important paralog of this gene is INHBB.
UniProtKB/Swiss-Prot for INHBC Gene
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins