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Aliases for INHBC Gene

Aliases for INHBC Gene

  • Inhibin, Beta C 2 3
  • Activin Beta-C Chain 3 4
  • Inhibin Beta C Chain 3
  • IHBC 3

External Ids for INHBC Gene

Previous GeneCards Identifiers for INHBC Gene

  • GC12P059241
  • GC12P057971
  • GC12P057545
  • GC12P056114
  • GC12P057828
  • GC12P054866

Summaries for INHBC Gene

Entrez Gene Summary for INHBC Gene

  • This gene encodes the beta C chain of inhibin, a member of the TGF-beta superfamily. This subunit forms heterodimers with beta A and beta B subunits. Inhibins and activins, also members of the TGF-beta superfamily, are hormones with opposing actions and are involved in hypothalamic, pituitary, and gonadal hormone secretion, as well as growth and differentiation of various cell types. [provided by RefSeq, Jul 2008]

GeneCards Summary for INHBC Gene

INHBC (Inhibin, Beta C) is a Protein Coding gene. Diseases associated with INHBC include gastric diffuse adenocarcinoma and endometrial adenocarcinoma. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and TGF-beta Signaling Pathway (sino). GO annotations related to this gene include growth factor activity and transforming growth factor beta receptor binding. An important paralog of this gene is INHBB.

UniProtKB/Swiss-Prot for INHBC Gene

  • Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins

Gene Wiki entry for INHBC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INHBC Gene

Genomics for INHBC Gene

Regulatory Elements for INHBC Gene

Genomic Location for INHBC Gene

Start:
57,434,685 bp from pter
End:
57,452,062 bp from pter
Size:
17,378 bases
Orientation:
Plus strand

Genomic View for INHBC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for INHBC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INHBC Gene

Proteins for INHBC Gene

  • Protein details for INHBC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55103-INHBC_HUMAN
    Recommended name:
    Inhibin beta C chain
    Protein Accession:
    P55103
    Secondary Accessions:
    • A1L3Y2

    Protein attributes for INHBC Gene

    Size:
    352 amino acids
    Molecular mass:
    38238 Da
    Quaternary structure:
    • Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only (By similarity).

neXtProt entry for INHBC Gene

Proteomics data for INHBC Gene at MOPED

Post-translational modifications for INHBC Gene

  • Glycosylation at Asn110, Asn143, and Asn161
  • Modification sites at PhosphoSitePlus

Other Protein References for INHBC Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for INHBC Gene

Domains for INHBC Gene

Suggested Antigen Peptide Sequences for INHBC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P55103

UniProtKB/Swiss-Prot:

INHBC_HUMAN :
  • P55103
Family:
  • Belongs to the TGF-beta family.
genes like me logo Genes that share domains with INHBC: view

No data available for Gene Families for INHBC Gene

Function for INHBC Gene

Molecular function for INHBC Gene

GENATLAS Biochemistry: inhibitin,beta C,murine homolog,TGFB superfamily member
UniProtKB/Swiss-Prot Function: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins

Gene Ontology (GO) - Molecular Function for INHBC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005160 transforming growth factor beta receptor binding TAS 7826378
GO:0005179 hormone activity IEA --
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with INHBC: view
genes like me logo Genes that share phenotypes with INHBC: view

Animal Models for INHBC Gene

MGI Knock Outs for INHBC:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for INHBC Gene

Localization for INHBC Gene

Subcellular locations from UniProtKB/Swiss-Prot for INHBC Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for INHBC Gene COMPARTMENTS Subcellular localization image for INHBC gene
Compartment Confidence
extracellular 4
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for INHBC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 7826378
GO:0005615 extracellular space IBA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with INHBC: view

Pathways for INHBC Gene

genes like me logo Genes that share pathways with INHBC: view

Pathways by source for INHBC Gene

Gene Ontology (GO) - Biological Process for INHBC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IBA --
GO:0040007 growth IEA --
GO:0042981 regulation of apoptotic process IBA --
GO:0043408 regulation of MAPK cascade IBA --
GO:0048468 cell development IBA --
genes like me logo Genes that share ontologies with INHBC: view

Transcripts for INHBC Gene

mRNA/cDNA for INHBC Gene

(12) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for INHBC Gene

Inhibin, beta C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for INHBC Gene

No ASD Table

Relevant External Links for INHBC Gene

GeneLoc Exon Structure for
INHBC
ECgene alternative splicing isoforms for
INHBC

Expression for INHBC Gene

mRNA expression in normal human tissues for INHBC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for INHBC Gene

This gene is overexpressed in Liver (49.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for INHBC Gene

SOURCE GeneReport for Unigene cluster for INHBC Gene Hs.632722

mRNA Expression by UniProt/SwissProt for INHBC Gene

P55103-INHBC_HUMAN
Tissue specificity: Expressed in benign prostatic hyperplasia.
genes like me logo Genes that share expressions with INHBC: view

Orthologs for INHBC Gene

This gene was present in the common ancestor of animals.

Orthologs for INHBC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INHBC 35
  • 99.15 (n)
  • 98.58 (a)
INHBC 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia INHBC 35
  • 83.81 (n)
  • 78.12 (a)
INHBC 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia INHBC 35
  • 86.01 (n)
  • 82.44 (a)
INHBC 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Inhbc 35
  • 81.1 (n)
  • 76.35 (a)
Inhbc 16
Inhbc 36
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia INHBC 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Inhbc 35
  • 81.2 (n)
  • 75.78 (a)
African clawed frog
(Xenopus laevis)
Amphibia actd-A-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493888 35
  • 51.87 (n)
  • 45 (a)
fruit fly
(Drosophila melanogaster)
Insecta Actbeta 36
  • 10 (a)
OneToMany
Species with no ortholog for INHBC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for INHBC Gene

ENSEMBL:
Gene Tree for INHBC (if available)
TreeFam:
Gene Tree for INHBC (if available)

Paralogs for INHBC Gene

Paralogs for INHBC Gene

Selected SIMAP similar genes for INHBC Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with INHBC: view

Variants for INHBC Gene

Sequence variations from dbSNP and Humsavar for INHBC Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs489391 -- 57,446,148(-) gacca(A/G)cctgg intron-variant
rs489467 -- 57,446,118(-) tctct(A/G)ctaaa intron-variant
rs511225 -- 57,433,259(-) ctact(C/T)cctgc upstream-variant-2KB
rs533975 -- 57,438,201(+) TAAAT(A/G)GGGAT intron-variant
rs560048 -- 57,435,346(-) TTGTC(A/G)GGACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for INHBC Gene

Variant ID Type Subtype PubMed ID
nsv899117 CNV Loss 21882294
nsv899118 CNV Gain 21882294
dgv513e1 CNV Complex 17122850
nsv428283 CNV Gain 18775914
nsv469411 CNV Loss 19166990

Relevant External Links for INHBC Gene

HapMap Linkage Disequilibrium report
INHBC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INHBC Gene

Disorders for INHBC Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for INHBC Gene including...

Search for INHBC Gene in MalaCards »

(1) University of Copenhagen DISEASES for INHBC Gene

Relevant External Links for INHBC

Genetic Association Database (GAD)
INHBC
Human Genome Epidemiology (HuGE) Navigator
INHBC
genes like me logo Genes that share disorders with INHBC: view

No data available for UniProtKB/Swiss-Prot for INHBC Gene

Publications for INHBC Gene

  1. Cloning of a new member of the TGF-beta family: a putative new activin beta C chain. (PMID: 7826378) Hoetten G. … Pohl J. (Biochem. Biophys. Res. Commun. 1995) 2 3 4 23
  2. Genetic variation in the inhibin pathway and risk of testicular germ cell tumors. (PMID: 18413775) Purdue M.P. … McGlynn K.A. (Cancer Res. 2008) 3 23 48
  3. Activin C antagonizes activin A in vitro and overexpression leads to pathologies in vivo. (PMID: 19095948) Gold E. … Risbridger G. (Am. J. Pathol. 2009) 3 23
  4. Activin betaC-subunit heterodimers provide a new mechanism of regulating activin levels in the prostate. (PMID: 12960042) Mellor S.L. … Risbridger G.P. (Endocrinology 2003) 3 23
  5. Structure, chromosomal localization, and expression analysis of the mouse inhibin/activin beta C (Inhbc) gene. (PMID: 8838799) Schmitt J. … Schrewe H. (Genomics 1996) 3 23

Products for INHBC Gene

Sources for INHBC Gene

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