INHBC Gene
protein-coding GIFtS: 57
GCID: GC12P057828
|
|
inhibin, beta C
| |
Aliases
for INHBC gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Inhibin, Beta C1 2 | | Activin Beta-C Chain2 3 | | IHBC2 | | Inhibin Beta C Chain2 |
Export aliases for INHBC gene to outside databasesPrevious GC identifers: GC12P059241 GC12P057971 GC12P057545 GC12P056114 GC12P054866 |
Summaries
for INHBC gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for INHBC:
This gene encodes the beta C chain of inhibin, a member of the TGF-beta superfamily. This subunit forms heterodimerswith beta A and beta B subunits. Inhibins and activins, also members of the TGF-beta superfamily, are hormones withopposing actions and are involved in hypothalamic, pituitary, and gonadal hormone secretion, as well as growth anddifferentiation of various cell types. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: INHBC_HUMAN, P55103Function: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitarygland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitaryhormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulinsecretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.Inhibins appear to oppose the functions of activins
Gene Wiki entry for INHBC
|
Genomic Views
for INHBC gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the INHBC gene promoter:
GR c-Fos C/EBPbeta AP-1 STAT5A Nkx2-5 c-Jun GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for INHBC
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INHBC |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q13.1 Ensembl cytogenetic band: 12q13.3 HGNC cytogenetic band: 12q13INHBC Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P057828: view genomic region
(about GC identifiers)
Start:
|
57,828,527 bp from pter |
End:
|
57,845,842 bp from pter |
Size:
|
17,316 bases |
Orientation:
|
plus strand |
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Proteins
for INHBC gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: INHBC_HUMAN, P55103 (See
protein sequence)Recommended Name: Inhibin beta C chain precursor Size: 352 amino acids; 38238 Da
Subunit: Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfidebonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of betasubunits only (By similarity)
Subcellular location: Secreted (By similarity)
Secondary accessions: A1L3Y2Explore the universe of human proteins at neXtProt for INHBC: NX_P55103
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P55103
INHBC Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005529.1
ENSEMBL proteins: ENSP00000449889 ENSP00000308716
Human Recombinant Protein Products for INHBC:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
TAS | -- |
INHBC for ontologies About GeneDecksing
INHBC Antibody Products:
Assay Products for INHBC: |
Protein
Domains /
Families
for INHBC gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
INHBC for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P55103ProtoNet protein and cluster: P55103 3 Blocks protein families: IPB001318 Inhibin beta C chain signature IPB001839 Transforming growth factor beta (TGFb) IPB002400 Growth factor cystine knot superfamily signature
UniProtKB/Swiss-Prot: INHBC_HUMAN, P55103Similarity: Belongs to the TGF-beta family |
Function
for INHBC gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: INHBC_HUMAN, P55103Function: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitarygland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitaryhormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulinsecretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.Inhibins appear to oppose the functions of activins Genatlas biochemistry entry for INHBC:inhibitin,beta C,murine homolog,TGFB superfamily member
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
INHBC for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for INHBC:
4 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Inhbc):
INHBC for phenotypes About GeneDecksing
Animal Models:
Mouse knock-outs for INHBC: Inhbe/InhbcInhbe/tm1Sjl Inhbctm1Zuk
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for INHBC (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for INHBC
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INHBC |
|
Pathways & Interactions
for INHBC gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | TGF-beta signaling pathway | | | 2 | PEDF Induced Signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Kegg Pathways (Kegg details for INHBC):
INHBC for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for INHBC
STRING Interaction
Network Preview (showing 5 interactants - click image to see 15)
5/15 Interacting proteins for INHBC (P551033 ENSP000003087164) via UniProtKB, MINT, STRING, and/or I2D (see all 15)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0040007 | growth |
IEA | -- |
INHBC for ontologies About GeneDecksing
|
Drugs & Compounds
for INHBC gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for INHBC
Search CenterWatch for drugs/clinical trials and news about INHBC
|
Transcripts
for INHBC gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for INHBC gene: NM_005538.2 Unigene Cluster for INHBC: Inhibin, beta C Hs.632722 [show with all ESTs]Unigene Representative Sequence: NM_0055382 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000550133 ENST00000309668(uc001snv.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for INHBC (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for INHBC
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: INHBC (NM_005538) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for INHBC | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INHBC |
Additional cDNA sequence: AK314849.1 BC020693.1 BC130324.1 BC130326.1 3 DOTS entries: DT.95363899 DT.121167073 DT.40279256 12 AceView cDNA sequences: AW473307 NM_005538 BC020693 BX105206 AA704770 BG566943 R94038 H79247 AI028366 AW451141 X82540 H79153
GeneLoc Exon Structure
|
Expression
for INHBC gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| INHBC expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGAACAAAA
About this image
See INHBC Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for INHBC
SOURCE GeneReport for Unigene cluster: Hs.632722
UniProtKB/Swiss-Prot: INHBC_HUMAN, P55103Tissue specificity: Expressed in benign prostatic hyperplasia
SABiosciences Custom PCR Arrays for INHBC
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for INHBC
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat INHBC | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INHBC | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INHBC | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INHBC |
Orthologs
for INHBC gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for INHBC gene from 4/12 species (see all 12) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
37(a) |
1 → many |
GL343212.1(901902-904866) |
African clawed frog
(Xenopus laevis) |
Amphibia |
actd-A-prov2 |
activin D precursor |
72.26(n) |
|
D49543.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
CABZ01117503.16 |
-- |
36(a) |
1 → many |
1(30609327-30615423) |
fruit fly
(Drosophila melanogaster) |
Insecta |
Actbeta6 |
Activin-beta |
8(a) |
1 → many |
4(1097946-1105418) |
ENSEMBL Gene Tree for INHBC (if available)
TreeFam Gene Tree for INHBC (if available) |
Paralogs
for INHBC gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for INHBC gene
- TGFB32 GDF112 MSTN2 INHBE2 INHBA2 TGFB12 INHBB2 TGFB22
3 SIMAP similar genes for INHBC using alignment to 2 protein entries: INHBC_HUMAN (see all proteins):DKFZp686A06204 INHBE INHBB
INHBC for paralogs About GeneDecksing
|
Genomic Variants
for INHBC gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for INHBC (57828527 - 57845842 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for INHBC
1 CNV: 3891 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing INHBC |
|
Disorders
/ Diseases
for INHBC gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
INHBC for disorders About GeneDecksing
OMIM gene information: 601233
OMIM disorders: --
15  diseases for INHBC: About MalaCardspre-eclampsia testicular germ cell tumor germ cell tumor polycystic ovary syndrome
gastric diffuse adenocarcinoma epithelial ovarian cancer eclampsia endometrial adenocarcinoma
ovarian cancer gout endometrial cancer adenocarcinoma
carcinoma prostatitis neuronitis
1 disease from the University of Copenhagen DISEASES database for INHBC:Gastric diffuse adenocarcinoma Human Genome Epidemiology (HuGE) Navigator: INHBC (7 documents)
Export disorders for INHBC gene to outside databases
|
Publications
for INHBC gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for INHBC gene, integrated from 9 sources (see all 28):
(articles sorted by number of sources associating them with INHBC) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning of a new member of the TGF-beta family: a putative new activin beta C chain. (PubMed id 7826378)1, 2, 3, 9 Hoetten G.... Pohl J. (1995)
- Inhibins, activins, and follistatins: expression of mRNAs and cellular localization in tissues from men with benign prostatic hyperplasia. (PubMed id 9428386)1, 2 Thomas T.Z.... Risbridger G.P. (1998)
- Activin betaC-subunit heterodimers provide a new mechanism of regulating activin levels in the prostate. (PubMed id 12960042)1, 9 Mellor S.L....Risbridger G.P. (2003)
- Structure, chromosomal localization, and expression analysis of the mouse inhibin/activin beta C (Inhbc) gene. (PubMed id 8838799)1, 9 Schmitt J....Schrewe H. (1996)
- Analysis of the function of activin betaC subunit using recombinant protein. (PubMed id 16627954)1, 9 Ushiro Y....Hasegawa Y. (2006)
- Activin C antagonizes activin A in vitro and overexpression leads to pathologies in vivo. (PubMed id 19095948)1, 9 Gold E....Risbridger G. (2009)
- Genetic variation in the inhibin pathway and risk of testicular germ cell tumors. (PubMed id 18413775)1, 9 Purdue M.P....McGlynn K.A. (2008)
- Inhibin-betaC subunit expression in normal and pathol ogical human placental tissues. (PubMed id 21117833)1 Mylonas I....Schiessl B. (2011)
- Inhibin secretion in women with the polycystic ovary syndrome before and after treatment with progesterone. (PubMed id 21529351)1 Dafopoulos K....Messinis I.E. (2011)
- Inhibin/activin-betaC subunit does not represent a pr ognostic parameter in human endometrial cancer. (PubMed id 20683603)1 KAoufl S.D....Mylonas I. (2011)
|
External Searches for INHBC gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing INHBC gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing INHBC gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing INHBC gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for INHBC gene:
Search GeneIP for patents involving INHBC
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for INHBC gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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