Aliases for INHBC Gene
External Ids for INHBC Gene
Previous GeneCards Identifiers for INHBC Gene
This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of homodimeric and heterodimeric activin complexes. The heterodimeric complex may function in the inhibition of activin A signaling. Transgenic mice overexpressing this gene exhibit defects in testis, liver and prostate. [provided by RefSeq, Aug 2016]
GeneCards Summary for INHBC Gene
INHBC (Inhibin Beta C Subunit) is a Protein Coding gene. Among its related pathways are TGF-beta signaling pathway (KEGG) and Signaling pathways regulating pluripotency of stem cells. GO annotations related to this gene include cytokine activity and hormone activity. An important paralog of this gene is INHBE.
UniProtKB/Swiss-Prot for INHBC Gene
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.