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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

INHBC Gene

protein-coding   GIFtS: 59
GCID: GC12P057828

Inhibin, Beta C

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Inhibin, Beta C1 2
Activin Beta-C Chain2 3
IHBC2
Inhibin Beta C Chain2

External Ids:    HGNC: 60681   Entrez Gene: 36262   Ensembl: ENSG000001751897   OMIM: 6012335   UniProtKB: P551033   

Export aliases for INHBC gene to outside databases

Previous GC identifers: GC12P059241 GC12P057971 GC12P057545 GC12P056114 GC12P054866


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for INHBC Gene:
This gene encodes the beta C chain of inhibin, a member of the TGF-beta superfamily. This subunit forms
heterodimers with beta A and beta B subunits. Inhibins and activins, also members of the TGF-beta superfamily,
are hormones with opposing actions and are involved in hypothalamic, pituitary, and gonadal hormone secretion, as
well as growth and differentiation of various cell types. (provided by RefSeq, Jul 2008)

GeneCards Summary for INHBC Gene: 
INHBC (inhibin, beta C) is a protein-coding gene. Diseases associated with INHBC include gastric diffuse adenocarcinoma, and cardiovascular disease risk factor ), and among its related super-pathways are STAT3 Pathway. GO annotations related to this gene include growth factor activity and transforming growth factor beta receptor binding. An important paralog of this gene is GDF11.

UniProtKB/Swiss-Prot: INHBC_HUMAN, P55103
Function: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary
gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and
pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid
differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on
their subunit composition. Inhibins appear to oppose the functions of activins

Gene Wiki entry for INHBC Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the INHBC gene promoter:
         GR   c-Fos   C/EBPbeta   AP-1   STAT5A   Nkx2-5   c-Jun   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidINHBC promoter sequence
   Search SABiosciences Chromatin IP Primers for INHBC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INHBC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.1   Ensembl cytogenetic band:  12q13.3   HGNC cytogenetic band: 12q13

INHBC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INHBC gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P057828:  view genomic region     (about GC identifiers)

Start:
57,828,527 bp from pter      End:
57,845,842 bp from pter
Size:
17,316 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: INHBC_HUMAN, P55103 (See protein sequence)
Recommended Name: Inhibin beta C chain precursor  
Size: 352 amino acids; 38238 Da
Subunit: Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more
disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers
of beta subunits only (By similarity)
Subcellular location: Secreted (By similarity)
Secondary accessions: A1L3Y2

Explore the universe of human proteins at neXtProt for INHBC: NX_P55103

Explore proteomics data for INHBC at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P55103

  • INHBC Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    INHBC Protein Expression
    REFSEQ proteins: NP_005529.1  
    ENSEMBL proteins: 
     ENSP00000449889   ENSP00000308716  

    Human Recombinant Protein Products for INHBC: 
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    R&D Systems Recombinant & Natural Proteins for INHBC (Activin C)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for INHBC
    Browse OriGene Protein Over-expression Lysates
    OriGene MassSpec for INHBC 
    OriGene Custom Protein Services for INHBC
    GenScript Custom Purified and Recombinant Proteins Services for INHBC
    Novus Biologicals INHBC Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    INHBC for ontologies           About GeneDecksing



    INHBC Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for INHBC 

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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR001111 TGF-b_N
     IPR015615 TGF-beta-rel
     IPR001318 Inhibin_betaC
     IPR001839 TGF-b_C
     IPR017948 TGFb_CS

    Graphical View of Domain Structure for InterPro Entry P55103

    ProtoNet protein and cluster: P55103

    3 Blocks protein domains:
    IPB001318 Inhibin beta C chain signature
    IPB001839 Transforming growth factor beta (TGFb)
    IPB002400 Growth factor cystine knot superfamily signature


    UniProtKB/Swiss-Prot: INHBC_HUMAN, P55103
    Similarity: Belongs to the TGF-beta family


    INHBC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: INHBC_HUMAN, P55103
    Function: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary
    gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and
    pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid
    differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on
    their subunit composition. Inhibins appear to oppose the functions of activins

         Genatlas biochemistry entry for INHBC:
    inhibitin,beta C,murine homolog,TGFB superfamily member

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005160transforming growth factor beta receptor binding TAS7826378
    GO:0005179hormone activity IEA--
    GO:0008083growth factor activity IEA--
         
    INHBC for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for INHBC:
     Decreased TP53 protein express 

         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Inhbc):
     homeostasis/metabolism  liver/biliary system  normal  reproductive system 

    INHBC for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for INHBC: Inhbctm1Zuk Inhbe/InhbcInhbe/tm1Sjl

       inGenious Targeting Laboratory - Custom generated mouse model solutions for INHBC 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for INHBC

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for INHBC 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for INHBC 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat INHBC
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate INHBC:
    hsa-miR-125a-3p hsa-miR-3919
    SwitchGear 3'UTR luciferase reporter plasmidINHBC 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of INHBC 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INHBC


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for INHBC About                                                                                                See pathways by source

    SuperPathContained pathways About
    1PEDF Induced Signaling
    Cytokine-cytokine receptor interaction0.43
    2TGF-beta Signaling Pathway
    TGF-beta Signaling Pathway
    3TGF-beta signaling pathway
    TGF-beta signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Sino Biological Pathway for INHBC 
        TGF-beta Signaling Pathway


    2         Kegg Pathways  (Kegg details for INHBC):
        Cytokine-cytokine receptor interaction
    TGF-beta signaling pathway


    INHBC for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for INHBC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/15 Interacting proteins for INHBC (P551033 ENSP000003087164) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACVR1BP368963, ENSP000002579634I2D: score=2 STRING: ENSP00000257963
    ACVR1Q047713, ENSP000002636404I2D: score=1 STRING: ENSP00000263640
    ACVR2BQ137053, ENSP000003403614I2D: score=1 STRING: ENSP00000340361
    INHBAP084763, ENSP000002422084I2D: score=1 STRING: ENSP00000242208
    INHBBP095293, ENSP000002952284I2D: score=2 STRING: ENSP00000295228
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0040007growth IEA--

    INHBC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for INHBC

    Search CenterWatch for drugs/clinical trials and news about INHBC

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for INHBC gene: 
    NM_005538.3  

    Unigene Cluster for INHBC:

    Inhibin, beta C
    Hs.632722  [show with all ESTs]
    Unigene Representative Sequence: NM_005538
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000550133 ENST00000309668(uc001snv.1)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat INHBC
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate INHBC:
    hsa-miR-125a-3p hsa-miR-3919
    SwitchGear 3'UTR luciferase reporter plasmidINHBC 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for INHBC
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat INHBC
    Clone
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    OriGene clones in human, mouse for INHBC (see all 7)
    OriGene ORF clones in mouse, rat for INHBC
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    GenScript: all cDNA clones in your preferred vector: INHBC (NM_005538)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INHBC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INHBC
    Sirion Biotech Customized lentivirus for stable overexpression of INHBC 
                         Customized lentivirus expression plasmids for stable overexpression of INHBC 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for INHBC
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INHBC
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INHBC

    Additional mRNA sequence: 

    AK314849.1 BC020693.1 BC130324.1 BC130326.1 

    3 DOTS entries:

    DT.95363899  DT.121167073  DT.40279256 

    12 AceView cDNA sequences:

    AW473307 NM_005538 BC020693 BX105206 BG566943 AA704770 R94038 AI028366 
    H79247 X82540 AW451141 H79153 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    INHBC expression in normal human tissues (normalized intensities)      INHBC embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGAACAAAA
    INHBC Expression
    About this image


    INHBC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
     
     Liver (Hepatobiliary System)

    See INHBC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for INHBC

    SOURCE GeneReport for Unigene cluster: Hs.632722

    UniProtKB/Swiss-Prot: INHBC_HUMAN, P55103
    Tissue specificity: Expressed in benign prostatic hyperplasia

        SABiosciences Custom PCR Arrays for INHBC
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INHBC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for INHBC gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Inhbc1 , 5 inhibin beta-C1, 5 81.1(n)1
    76.35(a)1
      10 (74.50 cM)5
    163251  NM_010565.31  NP_034695.11 
     1273563285 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    41(a)
    1 → many
    GL343212.1(900694-905249)
    African clawed frog
    (Xenopus laevis)
    Amphibia actd-A-prov2 activin D precursor 72.26(n)    D49543.1 
    zebrafish
    (Danio rerio)
    Actinopterygii INHBE6
    inhibin, beta E
    35(a)
    1 → many
    1(30609327-30615423)
    fruit fly
    (Drosophila melanogaster)
    Insecta Actbeta6
    Activin-beta
    10(a)
    1 → many
    4(1097946-1105418)


    ENSEMBL Gene Tree for INHBC (if available)
    TreeFam Gene Tree for INHBC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for INHBC gene
    GDF112  MSTN2  INHBE2  TGFB22  INHBB2  TGFB32  INHBA2  TGFB12  
    3 SIMAP similar genes for INHBC using alignment to 2 protein entries:     INHBC_HUMAN (see all proteins):
    DKFZp686A06204    INHBE    INHBB

    INHBC for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/355 SNPs in INHBC are shown (see all 355)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs571292981,2
    C--54878047(+) TATTT-/ATTT/ 
    ATTTATTT
    GAGAC
    1 -- int11NA 2
    rs124270271,2
    C,F,A,H--57826639(+) caccaT/Cgcccg 1 -- us2k14Minor allele frequency- C:0.38NA 8
    rs1817415721,2
    --57826655(+) TTTTTA/GTTTTA 1 -- us2k10--------
    rs1171182101,2
    C,F--57826790(+) ACAGAC/TGTGAG 1 -- us2k11Minor allele frequency- T:0.02NA 120
    rs1862192531,2
    --57826855(+) GAGTAC/GACTGA 1 -- us2k10--------
    rs731193061,2
    C,F--57826982(+) AATTTA/GTAGTT 1 -- us2k13Minor allele frequency- G:0.18NA EA 242
    rs5112251,2
    C,F,H--57827042(-) ctactC/Tcctgc 1 -- us2k1 tfbs320Minor allele frequency- T:0.04NS EA NA WA CSA 1630
    rs1160552601,2
    F--57827082(+) TATTTT/ATTATT 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1908236921,2
    --57827088(+) TTATTA/TATTTT 1 -- us2k10--------
    rs1459176631,2
    --57827142(+) AGTACA/GATTAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for INHBC (57828527 - 57845842 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for INHBC:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv469411CNV Loss19166990
    nsv899117CNV Loss21882294
    nsv899118CNV Gain21882294
    nsv428283CNV Gain18775914
    dgv513e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for INHBC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601233    OMIM disorders: --

    11 diseases for INHBC:    About MalaCards
    gastric diffuse adenocarcinoma    cardiovascular disease risk factor )    endometrial adenocarcinoma    gout
    pre-eclampsia    eclampsia    germ cell tumors    polycystic ovary syndrome
    ovarian cancer    adenocarcinoma    prostatitis

    1 disease from the University of Copenhagen DISEASES database for INHBC:
    Gastric diffuse adenocarcinoma

    INHBC for disorders           About GeneDecksing

    Genetic Association Database (GAD): INHBC
    Human Genome Epidemiology (HuGE) Navigator: INHBC (7 documents)

    Export disorders for INHBC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for INHBC gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with INHBC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a new member of the TGF-beta family: a putative new activin beta C chain. (PubMed id 7826378)1, 2, 3, 9 Hoetten G.... Pohl J. (1995)
    2. Genetic variation in the inhibin pathway and risk of testicular germ cell tumors. (PubMed id 18413775)1, 4, 9 Purdue M.P....McGlynn K.A. (2008)
    3. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (2010)
    4. Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. (PubMed id 19064572)1, 4 Palmieri R.T.... . (2008)
    5. Inhibins, activins, and follistatins: expression of mRNAs and cellular localization in tissues from men with benign prostatic hyperplasia. (PubMed id 9428386)1, 2 Thomas T.Z.... Risbridger G.P. (1998)
    6. Activin betaC-subunit heterodimers provide a new mechanism of regulating activin levels in the prostate. (PubMed id 12960042)1, 9 Mellor S.L....Risbridger G.P. (2003)
    7. Structure, chromosomal localization, and expression analysis of the mouse inhibin/activin beta C (Inhbc) gene. (PubMed id 8838799)1, 9 Schmitt J....Schrewe H. (1996)
    8. Analysis of the function of activin betaC subunit using recombinant protein. (PubMed id 16627954)1, 9 Ushiro Y....Hasegawa Y. (2006)
    9. Activin C antagonizes activin A in vitro and overexpression leads to pathologies in vivo. (PubMed id 19095948)1, 9 Gold E....Risbridger G. (2009)
    10. Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. (PubMed id 23263486)1 Kottgen A....Gieger C. (2013)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3626 HGNC: 6068 AceView: INHBC Ensembl:ENSG00000175189 euGenes: HUgn3626
    ECgene: INHBC Kegg: 3626 H-InvDB: INHBC

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for INHBC Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for INHBC Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for INHBC gene:
    Search GeneIP for patents involving INHBC

    GeneCards and IP:
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