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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

INHBB Gene

protein-coding   GIFtS: 61
GCID: GC02P121198

inhibin, beta B

(Previous names: inhibin, beta B (activin AB beta polypeptide) )
 Explore 33 diseases affiliated with
INHBB via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for INHBB    

Aliases
for INHBB gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Inhibin, Beta B1 2
Activin Beta-B Chain2 3
Inhibin, Beta B (Activin AB Beta Polypeptide)1
Activin AB Beta Polypeptide2
Inhibin Beta B Chain2
Inhibin, Beta-22

External Ids:    HGNC: 60671   Entrez Gene: 36252   Ensembl: ENSG000001630837   OMIM: 1473905   UniProtKB: P095293   

Export aliases for INHBB gene to outside databases

Previous GC identifers: GC02P118308 GC02P119023 GC02P121009 GC02P120819 GC02P113427


Summaries
for INHBB gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for INHBB:
The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown
to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum
levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker
for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary
severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and
a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to
form a heterodimer, activin AB, both of which stimulate FSH secretion. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: INHBB_HUMAN, P09529
Function: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary
gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary
hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin
secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.
Inhibins appear to oppose the functions of activins

Gene Wiki entry for INHBB


Genomic Views
for INHBB gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022135.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the INHBB gene promoter:
         Egr-3   AREB6   USF1   USF-1   USF2   USF-1:USF-2   Nkx2-5   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): INHBB promoter sequence
   Search SABiosciences Chromatin IP Primers for INHBB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INHBB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2cen-q13   Ensembl cytogenetic band:  2q14.2   HGNC cytogenetic band: 2cen-q13

INHBB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INHBB gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P121198:  view genomic region     (about GC identifiers)

Start:
 121,103,719 bp from pter      End:
 121,109,384 bp from pter
Size:
 5,666 bases      Orientation:
 plus strand

Proteins
for INHBB gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: INHBB_HUMAN, P09529 (See protein sequence)
Recommended Name: Inhibin beta B chain precursor  
Size: 407 amino acids; 45122 Da
Subunit: Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer
of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of
beta-A and beta-B. Interacts with FST and FSTL3
Subcellular location: Secreted
Secondary accessions: Q53T31 Q8N1D3

Explore the universe of human proteins at neXtProt for INHBB: NX_P09529

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P09529

    • INHBB Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002184.2  
    ENSEMBL proteins: 
     ENSP00000295228  
    Reactome Protein details: P09529
    Human Recombinant Protein Products: 
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    R&D Systems Recombinant & Natural Proteins for INHBB (Activin B)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: INHBB
    OriGene Custom Protein Services for INHBB 
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    Novus Biologicals INHBB Protein
    Novus Biologicals INHBB Lysate
    Sino Biological Recombinant Protein for INHBB
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0048471perinuclear region of cytoplasm IDA16650820


    INHBB for ontologies           About GeneDecksing



    INHBB Antibody Products: 
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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for INHBB gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    INHBB for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR000381 Inhibin_betaB
     IPR001111 TGF-b_N
     IPR015615 TGF-beta-rel
     IPR001839 TGF-b_C
     IPR017948 TGFb_CS

    Graphical View of Domain Structure for InterPro Entry P09529

    ProtoNet protein and cluster: P09529

    4 Blocks protein families:
    IPB000381 Inhibin beta B chain signature
    IPB001111 Transforming growth factor beta (TGFb)
    IPB001839 Transforming growth factor beta (TGFb)
    IPB002400 Growth factor cystine knot superfamily signature


    UniProtKB/Swiss-Prot: INHBB_HUMAN, P09529
    Similarity: Belongs to the TGF-beta family


    Function
    for INHBB gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: INHBB_HUMAN, P09529
    Function: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary
    gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary
    hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin
    secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.
    Inhibins appear to oppose the functions of activins

         Genatlas biochemistry entry for INHBB:
    inhibin,beta B subunit,dimerizing with INHBA,homodimerizing to form activin B,heterodimerizing with INHBA or INHA to
    form activin AB or inhibitin B,respectively

         Summary:  
    During embryonic development, INHBB as signaling molecule
    affects the following cells: Pancreatic Progenitor Cells in Ventral Pancreatic Bud, Pancreatic Progenitor Cells in Dorsal Pancreatic Bud

    miRNA
    Products:            		 OriGene 3'-UTR Clone: INHBB
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat INHBB
    8/95 QIAGEN miScript miRNA Assays for microRNAs that regulate INHBB (see all 95):
    hsa-miR-579 hsa-miR-607 hsa-miR-520e hsa-miR-4254 hsa-miR-218-1* hsa-miR-374a hsa-miR-759 hsa-miR-890
    SwitchGear 3'UTR luciferase reporter plasmid: INHBB 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for INHBB (see all 4)
    OriGene shRNA RFP: INHBB
    OriGene siRNA: INHBB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat INHBB

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for INHBB

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for INHBB (see all 2)
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    Sino Biological Human cDNA Clone for INHBB
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INHBB 

    Cell Line
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    Search LifeMap BioReagents cell lines for INHBB

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INHBB

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity TAS3122219
    GO:0005179hormone activity TAS3122219
    GO:0005515protein binding IPI12697670
    GO:0008083growth factor activity IEA--
    GO:0042803protein homodimerization activity IPI2575216


    INHBB for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for INHBB: Inhbbtm1Jae Inhbbtm1Grid
         11 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Inhbb):
     behavior/neurological  craniofacial  digestive/alimentary  endocrine/exocrine gland  homeostasis/metabolism 
     immune system  integument  mortality/aging  muscle  reproductive system 
     vision/eye 

    INHBB for phenotypes           About GeneDecksing


    Pathways & Interactions
    for INHBB gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signal transduction Activin A signaling regulation
    		Signal transduction Activin A signaling regulation1.00
    		Signal transduction_Activin A signaling regulation0.96
    2Signaling by NODAL
    		Signaling by Activin0.36
    		Antagonism of Activin by Follistatin0.00
    3Selected targets of Oct-3/4
    		Selected targets of Oct-3/41.00
    4AGE/RAGE pathway
    		AGE/RAGE pathway1.00
    5TGF-beta signaling pathway
    		TGF-beta signaling pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for INHBB
        Selected targets of Oct-3/4
    Signal transduction Activin A signaling regulation


    1 GeneGo (Thomson Reuters) Pathway for INHBB
        Signal transduction Activin A signaling regulation

    1 BioSystems Pathway for INHBB 
        AGE/RAGE pathway

    3        Reactome Pathways for INHBB
        Signaling by Activin
    Signal Transduction
    Antagonism of Activin by Follistatin


    2         Kegg Pathways  (Kegg details for INHBB):
        Cytokine-cytokine receptor interaction
    TGF-beta signaling pathway


    INHBB for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for INHBB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/19 Interacting proteins for INHBB (P095293 ENSP000002952284) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACVR1BP368963, ENSP000002579634I2D: score=3 STRING: ENSP00000257963
    ACVR2BQ137053, ENSP000003403614I2D: score=2 STRING: ENSP00000340361
    INHBCP551033, ENSP000003087164I2D: score=2 STRING: ENSP00000308716
    ACVR1Q047713, ENSP000002636404I2D: score=1 STRING: ENSP00000263640
    ACVR1CQ8NER53, ENSP000002433494I2D: score=1 STRING: ENSP00000243349
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001541ovarian follicle development NAS12790766
    GO:0006952defense response TAS3122219
    GO:0009267cellular response to starvation ISS--
    GO:0009605response to external stimulus IDA10320815
    GO:0030154cell differentiation NAS10320815


    INHBB for ontologies           About GeneDecksing



    Drugs & Compounds
    for INHBB gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    INHBB for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for INHBB
    1 Novoseek chemical compound relationship for INHBB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gnrh 11.8 1 8096491 (1)

    Search CenterWatch for drugs/clinical trials and news about INHBB 

    Transcripts
    for INHBB gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for INHBB gene: 
    NM_002193.2  

    Unigene Cluster for INHBB:

    Inhibin, beta B
    Hs.1735  [show with all ESTs]
    Unigene Representative Sequence: NM_002193
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000295228(uc002tmn.2)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: INHBB
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat INHBB
    8/95 QIAGEN miScript miRNA Assays for microRNAs that regulate INHBB (see all 95):
    hsa-miR-579 hsa-miR-607 hsa-miR-520e hsa-miR-4254 hsa-miR-218-1* hsa-miR-374a hsa-miR-759 hsa-miR-890
    SwitchGear 3'UTR luciferase reporter plasmid: INHBB 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for INHBB (see all 4)
    OriGene shRNA RFP: INHBB
    OriGene siRNA: INHBB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat INHBB
    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INHBB

    Additional cDNA sequence: 

    BC030029.2 BC127815.1 M13437.1 M31682.1 

    1 DOTS entry:

    DT.312280 

    24/46 AceView cDNA sequences (see all 46):

    AW016444 AW590794 CK430845 AI671596 BM720373 BM725606 BM678714 AA469911 
    W44338 M13437 AA600841 BM678087 BG395587 CB163739 BC030029 BG471754 
    C02533 BF793489 AI659282 M31682 NM_002193 BI545428 BU733413 W44452 

    GeneLoc Exon Structure


    Expression
    for INHBB gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    INHBB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATTAGTCAGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    INHBB expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Skeletal MuscleHyoid Arch MusclesMyoblastsSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMyoblastsSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Mature follicles (In-vitro growth and ...)

    See INHBB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for INHBB

    SOURCE GeneReport for Unigene cluster: Hs.1735
        SABiosciences Expression via Pathway-Focused PCR Arrays including INHBB: 
              Growth Factors in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INHBB
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INHBB

    Orthologs
    for INHBB gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for INHBB gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves INHBB1 inhibin, beta B 77.66(n)
    85.93(a)    		   396126  NM_205206.1  NP_990537.1 
    lizard
    (Anolis carolinensis)    		 Reptilia INHBB6
    		 --
    		 84(a)
    		 1 ↔ 1
    		 1(85012949-85022581)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.10902 Activin beta B subunit [Xenopus laevis, mRNA, 2716 more 78.12(n)    S61773.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii inhbb2 inhibin, beta B 74.73(n)   30275  NM_131068.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta activin-&bgr;3 cell growth transforming growth factor-beta
    receptor more    		 30(a)   102D4   --


    ENSEMBL Gene Tree for INHBB (if available)
    TreeFam Gene Tree for INHBB (if available) 

    Paralogs
    for INHBB gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for INHBB gene
    TGFB32  INHBC2  GDF112  MSTN2  INHBE2  INHBA2  TGFB12  TGFB22  
    4 SIMAP similar genes for INHBB using alignment to 2 protein entries:     INHBB_HUMAN (see all proteins):
    DKFZp686A06204    INHBA    INHBC    INHBE

    INHBB for paralogs           About GeneDecksing



    Genomic Variants
    for INHBB gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/125 NCBI SNPs in INHBB are shown (see all 125)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1505840591,2
    		--121101947(+) CCGGGG/TAGCTG 1 -- us2k10--------
    rs1836605021,2
    		--121102137(+) ACAGAC/GGCAGG 1 -- us2k10--------
    rs1879363941,2
    		--121102317(+) GGAGAA/GGAGGG 1 -- us2k10--------
    rs75786241,2
    		C,F,A,H,--121102479(+) AGGTAC/GGGACC 1 -- us2k18Minor allele frequency- G:0.13NS EA WA NA 778
    rs1487472601,2
    		--121102520(+) TCCCT-/CCCCCCCT 1 -- us2k10--------
    rs615462661,2
    		C,--121102534(+) TTTTCT/AGCCAA 1 -- us2k13Minor allele frequency- A:0.07CSA NA EA 241
    rs134193011,2
    		C,F,H,--121102572(+) GGAGAT/CTGTGC 1 -- us2k116Minor allele frequency- C:0.17NS EA WA NA 2332
    rs1426249361,2
    		C,--121102581(+) GCGGC-/TTTTTT 1 -- us2k10--------
    rs1386690951,2
    		--121103254(+) CGCAGC/GGCCGC 1 -- us2k10--------
    rs1492859901,2
    		--121103408(+) GAACCA/GGGGCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for INHBB (121103719 - 121109384 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for INHBB: --

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    Disorders / Diseases
    for INHBB gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    INHBB for disorders           About GeneDecksing

    OMIM gene information: 147390    OMIM disorders: --

    20/33 diseases for INHBB (see all 33):    About MalaCards
    pre-eclampsia    testicular germ cell tumor    ectopic pregnancy    germ cell tumor
    premature ovarian failure    polycystic ovary syndrome    anorexia nervosa    epithelial ovarian cancer
    pituitary adenoma    insulin resistance    varicocele    eclampsia
    goiter    hypogonadism    ovarian cancer    vaginitis
    aldosteronism    lung adenocarcinoma    pheochromocytoma    adenoma

    2 Novoseek disease relationships for INHBB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 2 1331774 (1), 12729472 (1)
    cancer 0 1 11344232 (1)

    Human Genome Epidemiology (HuGE) Navigator: INHBB (8 documents)

    Export disorders for INHBB gene to outside databases

    Publications
    for INHBB gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for INHBB gene, integrated from 9 sources (see all 136):
    (articles sorted by number of sources associating them with INHBB)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Differential binding and neutralization of activins A and B by follistatin and follistatin like-3 (FSTL-3/FSRP/FLRG). (PubMed id 12697670)1, 2 Schneyer A....Sidis Y. (2003)
    3. Purification and characterization of recombinant human activin B. (PubMed id 2364091)1, 2 Schmelzer C.H....Liegeois N. (1990)
    4. Characterization and regulation of testicular inhibin beta-subunit mRNA. (PubMed id 2739657)1, 2 Feng Z.M.... Chen C.L. (1989)
    5. Activin B: precursor sequences, genomic structure and in vitro activities. (PubMed id 2575216)1, 2 Mason A.J.... Schwall R.H. (1989)
    6. Inhibin: definition and nomenclature, including related substances. (PubMed id 3345731)1, 3 Burger H.G. and Igarashi M. (1988)
    7. Structure of two human ovarian inhibins. (PubMed id 3754442)1, 2 Mason A.J.... Seeburg P.H. (1986)
    8. The expression of inhibin beta B is high in human adipocytes, reduced by weight loss, and correlates to factors implicated in metabolic disease. (PubMed id 16650820)1, 9 Sjoholm K....Carlsson L.M. (2006)
    9. Inhibin/activin betaB-subunit expression in pheochromocytomas favors benign diagnosis. (PubMed id 11344232)1, 9 Salmenkivi K....Liu J. (2001)
    10. Endometrial inhibin/activin beta-B subunit expression is related to decidualization and is reduced in tubal ectopic pregnancy. (PubMed id 18381568)1, 9 Horne A.W....Duncan W.C. (2008)

    External Searches for INHBB gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing INHBB gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3625 HGNC: 6067 AceView: INHBB Ensembl:ENSG00000163083 euGenes: HUgn3625
    ECgene: INHBB Kegg: 3625 H-InvDB: INHBB

    Other Databases showing INHBB gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing INHBB gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for INHBB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for INHBB Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Inhibin

    Intellectual Property
    for INHBB gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for INHBB gene:
    Search GeneIP for patents involving INHBB

    GeneCards and IP:
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