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INHBB Gene

protein-coding   GIFtS: 64
GCID: GC02P121198

Inhibin, Beta B

(Previous names: inhibin, beta B (activin AB beta polypeptide))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Inhibin, Beta B1 2
Activin Beta-B Chain2 3
Inhibin, Beta B (Activin AB Beta Polypeptide)1
Activin AB Beta Polypeptide2
Inhibin Beta B Chain2
Inhibin, Beta-22

External Ids:    HGNC: 60671   Entrez Gene: 36252   Ensembl: ENSG000001630837   OMIM: 1473905   UniProtKB: P095293   

Export aliases for INHBB gene to outside databases

Previous GC identifers: GC02P118308 GC02P119023 GC02P121009 GC02P120819 GC02P113427


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for INHBB Gene:
The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been
shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In
addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore
be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various
extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a
growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and
also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion.
(provided by RefSeq, Jul 2008)

GeneCards Summary for INHBB Gene:
INHBB (inhibin, beta B) is a protein-coding gene. Diseases associated with INHBB include varicocele, and ectopic pregnancy. GO annotations related to this gene include growth factor activity and protein homodimerization activity. An important paralog of this gene is GDF11.

UniProtKB/Swiss-Prot: INHBB_HUMAN, P09529
Function: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary
gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and
pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid
differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on
their subunit composition. Inhibins appear to oppose the functions of activins

Gene Wiki entry for INHBB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the INHBB gene promoter:
         Egr-3   AREB6   USF1   USF-1   USF2   USF-1:USF-2   Nkx2-5   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): INHBB promoter sequence
   Search Chromatin IP Primers for INHBB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat INHBB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2cen-q13   Ensembl cytogenetic band:  2q14.2   HGNC cytogenetic band: 2q14.2

INHBB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INHBB gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P121198:  view genomic region     (about GC identifiers)

Start:
121,103,719 bp from pter      End:
121,109,384 bp from pter
Size:
5,666 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: INHBB_HUMAN, P09529 (See protein sequence)
Recommended Name: Inhibin beta B chain precursor  
Size: 407 amino acids; 45122 Da
Subunit: Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a
dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is
a dimer of beta-A and beta-B. Interacts with FST and FSTL3
Secondary accessions: Q53T31 Q8N1D3

Explore the universe of human proteins at neXtProt for INHBB: NX_P09529

Explore proteomics data for INHBB at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn93
  • Modification sites at PhosphoSitePlus

  • See INHBB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002184.2  
    ENSEMBL proteins: 
     ENSP00000295228  
    Reactome Protein details: P09529

    INHBB Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    5 InterPro protein domains:
     IPR000381 Inhibin_betaB
     IPR001111 TGF-b_N
     IPR015615 TGF-beta-rel
     IPR001839 TGF-b_C
     IPR017948 TGFb_CS

    Graphical View of Domain Structure for InterPro Entry P09529

    ProtoNet protein and cluster: P09529

    4 Blocks protein domains:
    IPB000381 Inhibin beta B chain signature
    IPB001111 Transforming growth factor beta (TGFb)
    IPB001839 Transforming growth factor beta (TGFb)
    IPB002400 Growth factor cystine knot superfamily signature


    UniProtKB/Swiss-Prot: INHBB_HUMAN, P09529
    Similarity: Belongs to the TGF-beta family


    INHBB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: INHBB_HUMAN, P09529
    Function: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary
    gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and
    pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid
    differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on
    their subunit composition. Inhibins appear to oppose the functions of activins

         Genatlas biochemistry entry for INHBB:
    inhibin,beta B subunit,dimerizing with INHBA,homodimerizing to form activin B,heterodimerizing with INHBA or INHA
    to form activin AB or inhibitin B,respectively

         Summary: 
    During embryonic development, INHBB as signaling molecule affects the following cells:
    Pancreas: Pancreatic Progenitor Cells (Ventral Pancreatic Bud), Pancreatic Progenitor Cells (Dorsal Pancreatic Bud)       to see all 2 cells

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity TAS3122219
    GO:0005179hormone activity TAS3122219
    GO:0005515protein binding IPI12697670
    GO:0008083growth factor activity IEA--
    GO:0042803protein homodimerization activity IPI2575216
         
    INHBB for ontologies           About GeneDecksing


    Phenotypes:
         11 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Inhbb):
     behavior/neurological  craniofacial  digestive/alimentary  endocrine/exocrine gland  homeostasis/metabolism 
     immune system  integument  mortality/aging  muscle  reproductive system 
     vision/eye 

    INHBB for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for INHBB: Inhbbtm1Grid Inhbbtm1Jae

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for INHBB
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for INHBB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for INHBB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for INHBB

    miRNA
    Products:
        
    miRTarBase miRNAs that target INHBB:
    hsa-mir-335-5p (MIRT018821)

    Block miRNA regulation of human, mouse, rat INHBB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate INHBB (see all 95):
    hsa-miR-579 hsa-miR-607 hsa-miR-520e hsa-miR-4254 hsa-miR-218-1* hsa-miR-374a hsa-miR-759 hsa-miR-890
    SwitchGear 3'UTR luciferase reporter plasmidINHBB 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat INHBB

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    GenScript: all cDNA clones in your preferred vector: INHBB (NM_002193)
    Sino Biological Human cDNA Clone for INHBB
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INHBB

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INHBB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    INHBB_HUMAN, P09529: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol1
    golgi apparatus1
    lysosome1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS3122219
    GO:0048471perinuclear region of cytoplasm IDA16650820

    INHBB for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for INHBB About   (see all 10)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Peptide hormone metabolism
    Peptide hormone metabolism0.30
    Peptide hormone biosynthesis0.00
    Glycoprotein hormones0.00
    2Signaling by NODAL
    Signaling by Activin0.39
    Antagonism of Activin by Follistatin0.00
    3Signaling by GPCR
    Signal Transduction0.58
    4PEDF Induced Signaling
    Cytokine-cytokine receptor interaction0.43
    5Packaging Of Telomere Ends
    Signal transduction Activin A signaling regulation0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for INHBB
        Signal transduction Activin A signaling regulation

    1 BioSystems Pathway for INHBB
        AGE/RAGE pathway

    1 Sino Biological Pathway for INHBB
        TGF-beta Signaling Pathway

    3 Reactome Pathways for INHBB
        Signaling by Activin
    Glycoprotein hormones
    Antagonism of Activin by Follistatin


    2 Kegg Pathways  (Kegg details for INHBB):
        Cytokine-cytokine receptor interaction
    TGF-beta signaling pathway


    INHBB for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including INHBB: 
              Growth Factors in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for INHBB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for INHBB (P095293 ENSP000002952284) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACVR1BP368963, ENSP000002579634I2D: score=3 STRING: ENSP00000257963
    ACVR2BQ137053, ENSP000003403614I2D: score=2 STRING: ENSP00000340361
    INHBCP551033, ENSP000003087164I2D: score=2 STRING: ENSP00000308716
    ACVR1Q047713, ENSP000002636404I2D: score=1 STRING: ENSP00000263640
    ACVR1CQ8NER53, ENSP000002433494I2D: score=1 STRING: ENSP00000243349
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001541ovarian follicle development NAS12790766
    GO:0006952defense response TAS3122219
    GO:0009267cellular response to starvation ISS--
    GO:0009612response to mechanical stimulus IDA10320815
    GO:0030154cell differentiation NAS10320815

    INHBB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for INHBB

    1 Novoseek inferred chemical compound relationship for INHBB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gnrh 11.8 1 8096491 (1)



    INHBB for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for INHBB gene: 
    NM_002193.2  

    Unigene Cluster for INHBB:

    Inhibin, beta B
    Hs.1735  [show with all ESTs]
    Unigene Representative Sequence: NM_002193
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000295228(uc002tmn.2)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate INHBB (see all 95):
    hsa-miR-579 hsa-miR-607 hsa-miR-520e hsa-miR-4254 hsa-miR-218-1* hsa-miR-374a hsa-miR-759 hsa-miR-890
    SwitchGear 3'UTR luciferase reporter plasmidINHBB 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat INHBB
      QuantiFast Probe-based Assays in human, mouse, rat INHBB

    Additional mRNA sequence: 

    BC030029.2 BC127815.1 M13437.1 M31682.1 

    1 DOTS entry:

    DT.312280 

    Selected AceView cDNA sequences (see all 46):

    CK430845 BM678714 AA469911 BM725606 AW016444 AI671596 BM720373 AW590794 
    M13437 AA600841 NM_002193 BF793489 BG471754 W44338 AI659282 BI545428 
    BC030029 BG395587 CB163739 M31682 BM678087 C02533 AA416873 AA505620 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    INHBB expression in normal human tissues (normalized intensities)      INHBB embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTAGTCAGA
    INHBB Expression
    About this image


    INHBB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Lung (Respiratory System)
             Alveolar type II cells
     
     Ovary (Reproductive System)
             Mature follicles
    INHBB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    INHBB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.1735
        Pathway & Disease-focused RT2 Profiler PCR Arrays including INHBB: 
              Growth Factors in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for INHBB
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    QuantiFast Probe-based Assays in human, mouse, rat INHBB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INHBB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for INHBB gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Inhbb1 , 5 inhibin beta-B1, 5 90.34(n)1
    97.3(a)1
      1 (52.29 cM)5
    163241  NM_008381.31  NP_032407.11 
     1194154655 
    chicken
    (Gallus gallus)
    Aves INHBB1 inhibin, beta B 79.44(n)
    89.58(a)
      396126  NM_205206.1  NP_990537.1 
    lizard
    (Anolis carolinensis)
    Reptilia INHBB6
    inhibin, beta B
    82(a)
    1 ↔ 1
    1(85010698-85023538)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.10902 Activin beta B subunit [Xenopus laevis, mRNA, 2716 more 78.12(n)    S61773.1 
    zebrafish
    (Danio rerio)
    Actinopterygii inhbb2 inhibin, beta B 74.73(n)   30275  NM_131068.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta activin-&bgr;3 cell growth transforming growth
    factor-beta receptor more
    30(a)   102D4   --


    ENSEMBL Gene Tree for INHBB (if available)
    TreeFam Gene Tree for INHBB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for INHBB gene
    GDF112  MSTN2  INHBE2  TGFB22  TGFB32  INHBC2  INHBA2  TGFB12  
    4 SIMAP similar genes for INHBB using alignment to 2 protein entries:     INHBB_HUMAN (see all proteins):
    DKFZp686A06204    INHBA    INHBC    INHBE

    INHBB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for INHBB (see all 155)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1505840591,2
    C--121101947(+) CCGGGG/TAGCTG 1 -- us2k10--------
    rs1836605021,2
    --121102137(+) ACAGAC/GGCAGG 1 -- us2k10--------
    rs1879363941,2
    --121102317(+) GGAGAA/GGAGGG 1 -- us2k10--------
    rs75786241,2
    C,F,A,H--121102479(+) AGGTAC/GGGACC 1 -- us2k18Minor allele frequency- G:0.13NS EA WA NA 778
    rs1487472601,2
    C--121102520(+) TCCCT-/CCCCCCCT 1 -- us2k10--------
    rs615462661,2
    C--121102534(+) TTTTCT/AGCCAA 1 -- us2k13Minor allele frequency- A:0.07CSA NA EA 241
    rs134193011,2
    C,F,H--121102572(+) GGAGAT/CTGTGC 1 -- us2k116Minor allele frequency- C:0.17NS EA WA NA 2332
    rs1426249361,2
    C--121102581(+) GCGGC-/TTTTTT 1 -- us2k10--------
    rs1386690951,2
    C--121103254(+) CGCAGC/GGCCGC 1 -- us2k10--------
    rs1492859901,2
    --121103408(+) GAACCA/GGGGCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for INHBB (121103719 - 121109384 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for INHBB:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv874969CNV Loss21882294
    nsv874970CNV Loss21882294
    nsv829640CNV Loss20364138
    nsv829641CNV Gain20364138

    Human Gene Mutation Database (HGMD): INHBB
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing INHBB
    DNA2.0 Custom Variant and Variant Library Synthesis for INHBB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 147390    OMIM disorders: --

    Selected diseases for INHBB (see all 31):    About MalaCards
    varicocele    ectopic pregnancy    premature ovarian failure    vaginitis
    testicular germ cell tumor    hypogonadism    polycystic ovary syndrome    goiter
    anorexia nervosa    eclampsia    lung adenocarcinoma    pre-eclampsia
    germ cell tumors    ependymoma    pituitary adenoma    pheochromocytoma
    medulloblastoma    age related macular degeneration    insulin resistance    cervical cancer


    INHBB for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for INHBB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 2 1331774 (1), 12729472 (1)
    cancer 0 1 11344232 (1)

    Genetic Association Database (GAD): INHBB
    Human Genome Epidemiology (HuGE) Navigator: INHBB (8 documents)

    Export disorders for INHBB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for INHBB gene, integrated from 10 sources (see all 144):
    (articles sorted by number of sources associating them with INHBB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variation in the inhibin pathway and risk of testicular germ cell tumors. (PubMed id 18413775)1, 4, 9 Purdue M.P....McGlynn K.A. (Cancer Res. 2008)
    2. A genome-wide association study on obesity and obesity-related traits. (PubMed id 21552555)1, 4 Wang K....Price R.A. (PLoS ONE 2011)
    3. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)
    4. Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium. (PubMed id 20634197)1, 4 Canzian F....Feigelson H.S. (Hum. Mol. Genet. 2010)
    5. Family-based analysis of candidate genes for polycystic ovary syndrome. (PubMed id 20200332)1, 4 Ewens K.G....Spielman R.S. (J. Clin. Endocrinol. Metab. 2010)
    6. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    7. Quantitative trait loci predicting circulating sex steroid hormones in men from the NCI-Breast and Prostate Cancer Cohort Consortium (BPC3). (PubMed id 19574343)1, 4 Ahn J....Hayes R.B. (Hum. Mol. Genet. 2009)
    8. Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. (PubMed id 19064572)1, 4 Palmieri R.T.... . (amp 2008)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Differential binding and neutralization of activins A and B by follistatin and follistatin like-3 (FSTL-3/FSRP/FLRG). (PubMed id 12697670)1, 2 Schneyer A.... Sidis Y. (Endocrinology 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 3625 HGNC: 6067 AceView: INHBB Ensembl:ENSG00000163083 euGenes: HUgn3625
    ECgene: INHBB Kegg: 3625 H-InvDB: INHBB

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for INHBB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for INHBB Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Inhibin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for INHBB gene:
    Search GeneIP for patents involving INHBB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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