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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

INHBA Gene

protein-coding   GIFtS: 64
GCID: GC07M041724

inhibin, beta A

(Previous names: inhibin, beta A (activin A, activin AB alpha polypeptide)...)
 Explore 73 diseases affiliated with
INHBA via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for INHBA    

Aliases
for INHBA gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Inhibin, Beta A1 2     Erythroid Differentiation Factor2
Inhibin, Beta A (Activin A, Activin AB Alpha Polypeptide)1 2     Follicle-Stimulating Hormone-Releasing Protein2
Activin Beta-A Chain2 3     FSH-Releasing Protein2
Erythroid Differentiation Protein2 3     Inhibin Beta A Chain2
EDF2 3     Inhibin, Beta-12
FRP2     

External Ids:    HGNC: 60661   Entrez Gene: 36242   Ensembl: ENSG000001226417   OMIM: 1472905   UniProtKB: P084763   

Export aliases for INHBA gene to outside databases

Previous GC identifers: GC07M041375 GC07M041469 GC07M041502 GC07M041695


Summaries
for INHBA gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for INHBA:
The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown
to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum
levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker
for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary
severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and
a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form
a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit
mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in
the human genome. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: INHBA_HUMAN, P08476
Function: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary
gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary
hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin
secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.
Inhibins appear to oppose the functions of activins

Gene Wiki entry for INHBA


Genomic Views
for INHBA gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the INHBA gene promoter:
         Sox5   Pax-5   IRF-1   Ik-3   NF-kappaB   Arnt   AREB6   FOXC1   NF-kappaB2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): INHBA promoter sequence
   Search SABiosciences Chromatin IP Primers for INHBA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INHBA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15-p13   Ensembl cytogenetic band:  7p14.1   HGNC cytogenetic band: 7p15-p13

INHBA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INHBA gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M041724:  view genomic region     (about GC identifiers)

Start:
 41,724,712 bp from pter      End:
 41,742,706 bp from pter
Size:
 17,995 bases      Orientation:
 minus strand

1 alternative location:
Chr7-,CRA_TCAG 41,768,467-41,782,571     

Proteins
for INHBA gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: INHBA_HUMAN, P08476 (See protein sequence)
Recommended Name: Inhibin beta A chain precursor  
Size: 426 amino acids; 47442 Da
Subunit: Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer
of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of
beta-A and beta-B. Interacts with FST and FSTL3
Subcellular location: Secreted
6/8 PDB 3D structures from and Proteopedia for INHBA (see all 8):
1NYS (3D)        1NYU (3D)        1S4Y (3D)        2ARP (3D)        2ARV (3D)        2B0U (3D)    
Secondary accessions: Q14599

Explore the universe of human proteins at neXtProt for INHBA: NX_P08476

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P08476

    • INHBA Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002183.1  
    ENSEMBL proteins: 
     ENSP00000242208   ENSP00000397197  
    Reactome Protein details: P08476
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant INHBA Protein
    R&D Systems Recombinant & Natural Proteins for INHBA (Activin A)
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    OriGene Protein Over-expression Lysate: INHBA
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    Novus Biologicals INHBA Proteins
    Novus Biologicals INHBA Lysates
    Sino Biological Recombinant Protein for INHBA
    ProSpec Recombinant Protein for INHBA
    Browse Proteins at Uscn

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0043509activin A complex IDA7890768
    GO:0043512inhibin A complex IDA7890768


    INHBA for ontologies           About GeneDecksing



    INHBA Antibody Products: 
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    Abcam antibodies for INHBA 
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    ThermoFisher Antibody for INHBA

    Assay Products for INHBA: 
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    See all other biochemical assays at R&D Systems
    GenScript Custom Assay Services for INHBA
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for INHBA gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    INHBA for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR001111 TGF-b_N
     IPR000491 Inhibin_betaA
     IPR015615 TGF-beta-rel
     IPR001839 TGF-b_C
     IPR017948 TGFb_CS

    Graphical View of Domain Structure for InterPro Entry P08476

    ProtoNet protein and cluster: P08476

    4 Blocks protein families:
    IPB000491 Inhibin beta A chain signature
    IPB001111 Transforming growth factor beta (TGFb)
    IPB001839 Transforming growth factor beta (TGFb)
    IPB002400 Growth factor cystine knot superfamily signature


    UniProtKB/Swiss-Prot: INHBA_HUMAN, P08476
    Similarity: Belongs to the TGF-beta family


    Function
    for INHBA gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: INHBA_HUMAN, P08476
    Function: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary
    gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary
    hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin
    secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.
    Inhibins appear to oppose the functions of activins

         Genatlas biochemistry entry for INHBA:
    inhibin,beta A subunit,14kDa,dimerizing with INHBA or INHBB,TGFB superfamily member,homodimerizing to form activing A
    stimulator of FSH secretion and involved in embryonic axis development or heterodimerizing with INHBB or INHA to form
    activin AB or inhibitin A,respectively

         Summary:  
    INHBA as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Definitive endoderm-like cells, Endoderm-like cell (see all 40).

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat INHBA
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate INHBA:
    hsa-miR-1233 hsa-miR-135b hsa-miR-205 hsa-miR-452* hsa-miR-135a
    SwitchGear 3'UTR luciferase reporter plasmid: INHBA 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for INHBA (see all 7)
    OriGene shRNA RFP: INHBA
    OriGene siRNA: INHBA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat INHBA

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for INHBA

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for INHBA (see all 3)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: INHBA (NM_002192)
    Sino Biological Human cDNA Clone for INHBA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INHBA 

    Cell Line
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    Search LifeMap BioReagents cell lines for INHBA

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INHBA

    Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ----
    GO:0005125cytokine activity IDA9884026
    GO:0005179hormone activity TAS12456957
    GO:0005515protein binding IPI12697670
    GO:0008083growth factor activity TAS12324653


    INHBA for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Inhbatm1Zuk for INHBA
         15/16 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Inhba) (see all 16):
     behavior/neurological  craniofacial  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     growth/size  hematopoietic system  homeostasis/metabolism  integument  mortality/aging 
     muscle  normal  renal/urinary system  reproductive system  skeleton 

    INHBA for phenotypes           About GeneDecksing


    Pathways & Interactions
    for INHBA gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signal transduction Activin A signaling regulation
    		Signal transduction Activin A signaling regulation1.00
    		Signal transduction_Activin A signaling regulation0.96
    2Integrated Pancreatic Cancer Pathway
    		Integrated Pancreatic Cancer Pathway1.00
    		Integrated Pancreatic Cancer Pathway0.99
    3Signaling by NODAL
    		Signaling by Activin0.36
    		Antagonism of Activin by Follistatin0.00
    4PKA activation in glucagon signalling
    		Development_Role of Activin A in cell differentiation and proliferation0.33
    		Development Role of Activin A in cell differentiation and proliferation0.33
    5TGF Beta Signaling Pathway
    		TGF Beta Signaling Pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for INHBA
        Development Role of Activin A in cell differentiation and proliferation
    Signal transduction Activin A signaling regulation


    2 GeneGo (Thomson Reuters) Pathways for INHBA
        Signal transduction Activin A signaling regulation
    Development Role of Activin A in cell differentiation and proliferation

    5 BioSystems Pathways for INHBA 
        Senescence and Autophagy
    TGF Beta Signaling Pathway
    Integrated Pancreatic Cancer Pathway
    Integrated Pancreatic Cancer Pathway
    ALK1 signaling events

    3        Reactome Pathways for INHBA
        Signaling by Activin
    Signal Transduction
    Antagonism of Activin by Follistatin


    2         Kegg Pathways  (Kegg details for INHBA):
        Cytokine-cytokine receptor interaction
    TGF-beta signaling pathway


    INHBA for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for INHBA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/26 Interacting proteins for INHBA (P084762, 3 ENSP000002422084) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACVR2BQ137053, ENSP000003403614I2D: score=4 STRING: ENSP00000340361
    ACVR1BP368963, ENSP000002579634I2D: score=2 STRING: ENSP00000257963
    CHRDL2Q6WN343, ENSP000002636714I2D: score=2 STRING: ENSP00000263671
    FSTP198833, ENSP000002567594I2D: score=2 STRING: ENSP00000256759
    ACVR1Q047713, ENSP000002636404I2D: score=1 STRING: ENSP00000263640
    About this table

    Gene Ontology (GO): 5/41 biological process terms (GO ID links to tree view) (see all 41):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle IDA9884026
    GO:0001541ovarian follicle development NAS9166111
    GO:0001707mesoderm formation ----
    GO:0001942hair follicle development IGI10932194
    GO:0002244hematopoietic progenitor cell differentiation IDA15451575


    INHBA for ontologies           About GeneDecksing



    Drugs & Compounds
    for INHBA gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    INHBA for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for INHBA
    7 Novoseek chemical compound relationships for INHBA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5-aza-2'deoxycytidine 29 5 19308293 (2), 19240652 (1)
    oligonucleotide 22.7 5 19240652 (2), 10810314 (1), 19308293 (1), 1863557 (1)
    progesterone 12.4 1 10965925 (1)
    testosterone 9.39 1 1750706 (1)
    cycloheximide 2.59 1 10906757 (1)
    forskolin 1.38 2 12538609 (1)
    estrogen 0 2 7536182 (1)

    Search CenterWatch for drugs/clinical trials and news about INHBA 

    Transcripts
    for INHBA gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for INHBA gene: 
    NM_002192.2  

    Unigene Cluster for INHBA:

    Inhibin, beta A
    Hs.583348  [show with all ESTs]
    Unigene Representative Sequence: BX648811
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000242208(uc003thq.3 uc003thr.3) ENST00000464515 ENST00000442711


    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate INHBA:
    hsa-miR-1233 hsa-miR-135b hsa-miR-205 hsa-miR-452* hsa-miR-135a
    SwitchGear 3'UTR luciferase reporter plasmid: INHBA 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for INHBA (see all 7)
    OriGene shRNA RFP: INHBA
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat INHBA
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INHBA
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INHBA

    Additional cDNA sequence: 

    AF218018.1 AK222742.1 AK290584.1 BC007858.2 BX648811.1 D49743.1 J03634.1 M13436.1 
    X72498.1 

    9 DOTS entries:

    DT.91741308  DT.452433  DT.92030578  DT.92008315  DT.99942006  DT.100707716  DT.102831894  DT.40316631 
    DT.95173216 

    24/110 AceView cDNA sequences (see all 110):

    AI738775 CA310336 AU139087 AI905388 BP341643 BQ574581 CN480753 CD367517 
    BM555692 BF439415 AA948385 AL599843 CK825381 AI753619 BQ006749 CD366041 
    BQ267396 BC007858 BF000451 BQ003646 T29604 BM554468 AI188646 BG747890 

    GeneLoc Exon Structure


    Expression
    for INHBA gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    INHBA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATCGTGGAGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    INHBA expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    CartilageCervical Intervertebral DiscIntervertebral Disc Annulus Fibrosus CellsCartilage
    CartilageLumbar Intervertebral DiscIntervertebral Disc Annulus Fibrosus CellsCartilage
    CartilageSacral Intervertebral DiscIntervertebral Disc Annulus Fibrosus CellsCartilage
    CartilageThoracic Intervertebral DiscIntervertebral Disc Annulus Fibrosus CellsCartilage
    PancreasDorsal Pancreatic BudAlpha Progenitor CellsPancreas
    PancreasVentral Pancreatic BudAlpha Progenitor CellsPancreas
    Primitive StreakPrimitive NodePrimitive Node CellsEarly Embryo
    TestisTestis CordDeveloping Peritubular Myoid CellsReproductive System
    HeartEndocardiumCushion Mesenchymal CellsEndocardium
    CartilageLumbar Intervertebral DiscCartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Mature follicles (In-vitro growth and ...)

    See INHBA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for INHBA

    SOURCE GeneReport for Unigene cluster: Hs.583348
        SABiosciences Expression via Pathway-Focused PCR Arrays including INHBA (see all 8): 
              Growth Factors in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Common Cytokines in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INHBA
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INHBA

    Orthologs
    for INHBA gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for INHBA gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves INHBA1 inhibin, beta A 80.35(n)
    84.43(a)    		   396361  NM_205396.1  NP_990727.1 
    lizard
    (Anolis carolinensis)    		 Reptilia INHBA6
    		 --
    		 83(a)
    		 1 ↔ 1
    		 6(49715246-49730887)
    zebrafish
    (Danio rerio)    		 Actinopterygii AF475092.12   -- 75.89(n)   30072  AF475092.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Actbeta1 Activin-beta 46.42(n)
    35.57(a)    		   43826  NM_143685.2  NP_651942.2 


    ENSEMBL Gene Tree for INHBA (if available)
    TreeFam Gene Tree for INHBA (if available) 

    Paralogs
    for INHBA gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for INHBA gene
    TGFB32  INHBC2  GDF112  MSTN2  INHBE2  TGFB12  INHBB2  TGFB22  
    2 SIMAP similar genes for INHBA using alignment to 2 protein entries:     INHBA_HUMAN (see all proteins):
    DKFZp686A06204    INHBB

    INHBA for paralogs           About GeneDecksing



    Genomic Variants
    for INHBA gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/237 NCBI SNPs in INHBA are shown (see all 237)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1456635061,2
    		--41728140(+) AATAAC/TAATTA 1 -- ds50010--------
    rs1506823431,2
    		--41728251(+) GAAAAC/TACTTG 1 -- ds50010--------
    rs1512003701,2
    		--41728310(+) CGATT-/AAAAAA 1 -- ds50010--------
    rs1151240681,2
    		C,F,--41728654(+) ACACGA/CTTGTT 1 -- ut311Minor allele frequency- C:0.02WA 118
    rs1391040181,2
    		C,--41728701(+) ATGCC-/TGTGTG
                TGTGT     		1 -- ut310--------
    rs1399239801,2
    		--41728811(+) CCTGTC/GATGGG 1 -- ut310--------
    rs1825513481,2
    		--41728877(+) CTGCAA/GACTAG 1 -- ut310--------
    rs1871233041,2
    		--41728937(+) TACCCC/TGTTTA 1 -- ut310--------
    rs1919808351,2
    		--41729022(+) TCTCTC/TTCACT 1 -- ut310--------
    rs1513042581,2
    		--41729107(+) TTTTG-/TTTTTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for INHBA (41724712 - 41742706 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for INHBA: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for INHBA gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    INHBA for disorders           About GeneDecksing

    OMIM gene information: 147290    OMIM disorders: --

    20/73 diseases for INHBA (see all 73):    About MalaCards
    pre-eclampsia    testicular germ cell tumor    dental caries    ectopic pregnancy
    clear cell adenocarcinoma    familial adenomatous polyposis    germ cell tumor    ovarian clear cell adenocarcinoma
    premature ovarian failure    polycystic ovary syndrome    intrauterine infections    myocardial infarction
    acute myocardial infarction    somatotrophinoma    esophageal squamous cell carcinoma    squamous cell carcinoma
    pancreatic ductal adenocarcinoma    inflammatory bowel disease    goiter    brain injury

    10/14 Novoseek disease relationships for INHBA gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sex cord-stromal tumor 56.7 4 10747314 (3)
    erythroleukemia 46.2 3 1542647 (1), 1402687 (1), 2323849 (1)
    esophageal carcinoma 40.4 6 15355896 (1), 18695873 (1), 12469187 (1), 17909904 (1)
    epithelial tumor 20.8 1 10747314 (1)
    tumors 19.8 18 10747314 (3), 17609433 (2), 12206515 (2), 7829603 (1) (see all 9)
    pheochromocytoma 19.8 5 10810314 (3), 11344232 (1), 17680997 (1)
    adenoma 14.7 5 9691207 (1), 7599706 (1), 12821114 (1)
    goiter 14.6 2 11069203 (1), 12729472 (1)
    endometrial carcinoma 13.8 1 11585411 (1)
    carcinoma 11.5 4 19308293 (1), 9570994 (1), 17909904 (1), 12729472 (1)

    Genetic Association Database (GAD): INHBA
    Human Genome Epidemiology (HuGE) Navigator: INHBA (15 documents)

    Export disorders for INHBA gene to outside databases

    Publications
    for INHBA gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for INHBA gene, integrated from 9 sources (see all 275):
    (articles sorted by number of sources associating them with INHBA)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The structure of FSTL3.activin A complex. Differential binding of N- terminal domains influences follistatin-type antagonist specificity. (PubMed id 18768470)1, 2 Stamler R....Thompson T.B. (2008)
    2. Mutational analysis of the mature peptide region of inhibin genes in Indian women with ovarian failure. (PubMed id 15205401)1, 4 Dixit H....Singh L. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Structures of an ActRIIB:activin A complex reveal a novel binding mode for TGF-beta ligand:receptor interactions. (PubMed id 12660162)1, 2 Thompson T.B.... Jardetzky T.S. (2003)
    5. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    6. Differential binding and neutralization of activins A and B by follistatin and follistatin like-3 (FSTL-3/FSRP/FLRG). (PubMed id 12697670)1, 2 Schneyer A....Sidis Y. (2003)
    7. Structure and sequence analysis of the human activin beta A subunit gene. (PubMed id 1777673)1, 2 Tanimoto K.... Fukamizu A. (1991)
    8. Erythroid differentiation factor is encoded by the same mRNA as that of the inhibin beta A chain. (PubMed id 3267209)1, 2 Murata M.... Muramatsu M. (1988)
    9. Inhibin: definition and nomenclature, including related substances. (PubMed id 3345731)1, 3 Burger H.G. and Igarashi M. (1988)
    10. Structure of two human ovarian inhibins. (PubMed id 3754442)1, 2 Mason A.J.... Seeburg P.H. (1986)

    External Searches for INHBA gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing INHBA gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3624 HGNC: 6066 AceView: INHBA Ensembl:ENSG00000122641 euGenes: HUgn3624
    ECgene: INHBA Kegg: 3624 H-InvDB: INHBA

    Other Databases showing INHBA gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing INHBA gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for INHBA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for INHBA Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Activin

    Intellectual Property
    for INHBA gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for INHBA gene:
    Search GeneIP for patents involving INHBA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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