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INHBA Gene

protein-coding   GIFtS: 65
GCID: GC07M041724

Inhibin, Beta A

(Previous names: inhibin, beta A (activin A, activin AB alpha polypeptide))
  See INHBA-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Inhibin, Beta A1 2     Erythroid Differentiation Factor2
Inhibin, Beta A (Activin A, Activin AB Alpha Polypeptide)1 2     Follicle-Stimulating Hormone-Releasing Protein2
Activin Beta-A Chain2 3     FSH-Releasing Protein2
Erythroid Differentiation Protein2 3     Inhibin Beta A Chain2
EDF2 3     Inhibin, Beta-12
FRP2     

External Ids:    HGNC: 60661   Entrez Gene: 36242   Ensembl: ENSG000001226417   OMIM: 1472905   UniProtKB: P084763   

Export aliases for INHBA gene to outside databases

Previous GC identifers: GC07M041375 GC07M041469 GC07M041502 GC07M041695


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for INHBA Gene:
The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been
shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In
addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore
be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various
extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a
growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and
also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion.
Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor
subunit mRNA and that only one gene for this mRNA exists in the human genome. (provided by RefSeq, Jul 2008)

GeneCards Summary for INHBA Gene:
INHBA (inhibin, beta A) is a protein-coding gene. Diseases associated with INHBA include ovary adenocarcinoma, and preterm premature rupture of the membranes. GO annotations related to this gene include cytokine activity and identical protein binding. An important paralog of this gene is GDF11.

UniProtKB/Swiss-Prot: INHBA_HUMAN, P08476
Function: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary
gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and
pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid
differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on
their subunit composition. Inhibins appear to oppose the functions of activins

Gene Wiki entry for INHBA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007819.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the INHBA gene promoter:
         Sox5   Pax-5   IRF-1   Ik-3   NF-kappaB   Arnt   AREB6   FOXC1   NF-kappaB2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): INHBA promoter sequence
   Search Chromatin IP Primers for INHBA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat INHBA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15-p13   Ensembl cytogenetic band:  7p14.1   HGNC cytogenetic band: 7p15-p13

INHBA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INHBA gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M041724:  view genomic region     (about GC identifiers)

Start:
41,724,712 bp from pter      End:
41,742,706 bp from pter
Size:
17,995 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 41,768,467-41,782,571     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: INHBA_HUMAN, P08476 (See protein sequence)
Recommended Name: Inhibin beta A chain precursor  
Size: 426 amino acids; 47442 Da
Subunit: Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a
dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is
a dimer of beta-A and beta-B. Interacts with FST and FSTL3
Selected PDB 3D structures from and Proteopedia for INHBA (see all 8):
1NYS (3D)        1NYU (3D)        1S4Y (3D)        2ARP (3D)        2ARV (3D)        2B0U (3D)    
Secondary accessions: Q14599

Explore the universe of human proteins at neXtProt for INHBA: NX_P08476

Explore proteomics data for INHBA at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn165
  • Modification sites at PhosphoSitePlus

  • See INHBA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002183.1  
    ENSEMBL proteins: 
     ENSP00000242208   ENSP00000397197  
    Reactome Protein details: P08476

    INHBA Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant INHBA Protein
    R&D Systems Recombinant & Natural Proteins for INHBA (Activin A)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for INHBA
    OriGene Protein Over-expression Lysate for INHBA
    OriGene MassSpec for INHBA
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    GenScript Custom Purified and Recombinant Proteins Services for INHBA
    Novus Biologicals INHBA Proteins
    Novus Biologicals INHBA Lysates
    Sino Biological Recombinant Protein for INHBA
    Sino Biological Cell Lysate for INHBA
    ProSpec Recombinant Protein for INHBA
    Browse Proteins at Cloud-Clone Corp.

     
    eBioscience Proteins for INHBA: (see all 2
                        Human Activin A Recombinant Protein 5 ug

    INHBA Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for INHBA (Activin A)
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    Novus Biologicals INHBA Antibodies
    Abcam antibodies for INHBA
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for INHBA
    LSBio Antibodies in human, mouse, rat for INHBA

    INHBA Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for INHBA
    R&D Systems Flow Cytometry Kits for INHBA (Activin A)         (see first)
    R&D Systems ELISAs for INHBA (Activin A)
    R&D Systems Proteome Profiler Antibody Arrays for INHBA (Activin A)
    See all other biochemical assays at R&D Systems
    GenScript Custom Assay Services for INHBA
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for INHBA 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    5 InterPro protein domains:
     IPR001111 TGF-b_N
     IPR015615 TGF-beta-rel
     IPR000491 Inhibin_betaA
     IPR001839 TGF-b_C
     IPR017948 TGFb_CS

    Graphical View of Domain Structure for InterPro Entry P08476

    ProtoNet protein and cluster: P08476

    4 Blocks protein domains:
    IPB000491 Inhibin beta A chain signature
    IPB001111 Transforming growth factor beta (TGFb)
    IPB001839 Transforming growth factor beta (TGFb)
    IPB002400 Growth factor cystine knot superfamily signature


    UniProtKB/Swiss-Prot: INHBA_HUMAN, P08476
    Similarity: Belongs to the TGF-beta family


    Find genes that share domains with INHBA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: INHBA_HUMAN, P08476
    Function: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary
    gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and
    pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid
    differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on
    their subunit composition. Inhibins appear to oppose the functions of activins

         Genatlas biochemistry entry for INHBA:
    inhibin,beta A subunit,14kDa,dimerizing with INHBA or INHBB,TGFB superfamily member,homodimerizing to form
    activing A stimulator of FSH secretion and involved in embryonic axis development or heterodimerizing with INHBB
    or INHA to form activin AB or inhibitin A,respectively

         Summary: 
    INHBA as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
          selected tissues (see all 12)      fully expand
    Endoderm: Endoderm-like cells, Activin A-induced embryoid bodies (Mm)      fully expand to see all 6 cells
    Primitive Streak: Posterior primitive streak cells, Primitive Streak Mesendoderm cells      fully expand to see all 5 cells

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ----
    GO:0005125cytokine activity IDA9884026
    GO:0005179hormone activity TAS12456957
    GO:0005515protein binding IPI12697670
    GO:0008083growth factor activity TAS12324653
         
    Find genes that share ontologies with INHBA           About GenesLikeMe


    Phenotypes:
         Selected MGI mutant phenotypes (inferred from 3 alleles(MGI details for Inhba) (see all 16):
     behavior/neurological  craniofacial  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     growth/size/body  hematopoietic system  homeostasis/metabolism  integument  mortality/aging 
     muscle  normal  renal/urinary system  reproductive system  skeleton 

    Find genes that share phenotypes with INHBA           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Inhbatm1Zuk for INHBA

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for INHBA
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for INHBA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for INHBA
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for INHBA

    miRNA
    Products:
        
    miRTarBase miRNAs that target INHBA:
    hsa-mir-10b-5p (MIRT047412), hsa-mir-148b-3p (MIRT019457), hsa-mir-31-3p (MIRT038928)

    Block miRNA regulation of human, mouse, rat INHBA using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate INHBA:
    hsa-miR-1233 hsa-miR-135b hsa-miR-205 hsa-miR-452* hsa-miR-135a
    SwitchGear 3'UTR luciferase reporter plasmidINHBA 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for INHBA
    Predesigned siRNA for gene silencing in human, mouse, rat INHBA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for INHBA

    Clone
    Products:
         
    OriGene clones in human, mouse for INHBA (see all 6)
    OriGene ORF clones in mouse, rat for INHBA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: INHBA (NM_002192)
    Sino Biological Human cDNA Clone for INHBA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INHBA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INHBA

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for INHBA
    Browse ESI BIO Cell Lines and PureStem Progenitors for INHBA 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INHBA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    INHBA_HUMAN, P08476: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    endoplasmic reticulum2
    mitochondrion2
    cytosol1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0043509activin A complex IDA7890768
    GO:0043512inhibin A complex IDA7890768

    Find genes that share ontologies with INHBA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for INHBA About   (see all 14)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide hormone metabolism
    Peptide hormone metabolism0.30
    Peptide hormone biosynthesis0.00
    Glycoprotein hormones0.00
    2Signaling by NODAL
    Signaling by Activin0.39
    Antagonism of Activin by Follistatin0.00
    3Signaling by GPCR
    Signal Transduction0.58
    4PEDF Induced Signaling
    Cytokine-cytokine receptor interaction0.43
    5Packaging Of Telomere Ends
    Signal transduction Activin A signaling regulation0.40


    Find genes that share SuperPaths with INHBA           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for INHBA
        Signal transduction Activin A signaling regulation
    Development Role of Activin A in cell differentiation and proliferation

    5 BioSystems Pathways for INHBA
        TGF Beta Signaling Pathway
    Senescence and Autophagy
    Cardiac Progenitor Differentiation
    Integrated Pancreatic Cancer Pathway
    ALK1 signaling events

    1 Sino Biological Pathway for INHBA
        TGF-beta Signaling Pathway

    3 Reactome Pathways for INHBA
        Signaling by Activin
    Glycoprotein hormones
    Antagonism of Activin by Follistatin


    2 Kegg Pathways  (Kegg details for INHBA):
        Cytokine-cytokine receptor interaction
    TGF-beta signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including INHBA (see all 8): 
              Growth Factors in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Common Cytokines in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for INHBA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for INHBA (P084761, 2, 3 ENSP000002422084) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACVR2BQ137053, ENSP000003403614I2D: score=4 STRING: ENSP00000340361
    ACVR1BP368963, ENSP000002579634I2D: score=2 STRING: ENSP00000257963
    CHRDL2Q6WN343, ENSP000002636714I2D: score=2 STRING: ENSP00000263671
    FSTP198833, ENSP000002567594I2D: score=2 STRING: ENSP00000256759
    ACVR1Q047713, ENSP000002636404I2D: score=1 STRING: ENSP00000263640
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 42):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle IDA9884026
    GO:0001541ovarian follicle development NAS9166111
    GO:0001707mesoderm formation ----
    GO:0001942hair follicle development IGI10932194
    GO:0002244hematopoietic progenitor cell differentiation IDA15451575

    Find genes that share ontologies with INHBA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for INHBA

    7 Novoseek inferred chemical compound relationships for INHBA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5-aza-2'deoxycytidine 29 5 19308293 (2), 19240652 (1)
    oligonucleotide 22.7 5 19240652 (2), 10810314 (1), 19308293 (1), 1863557 (1)
    progesterone 12.4 1 10965925 (1)
    testosterone 9.39 1 1750706 (1)
    cycloheximide 2.59 1 10906757 (1)
    forskolin 1.38 2 12538609 (1)
    estrogen 0 2 7536182 (1)



    Find genes that share compounds with INHBA           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for INHBA gene: 
    NM_002192.2  

    Unigene Cluster for INHBA:

    Inhibin, beta A
    Hs.583348  [show with all ESTs]
    Unigene Representative Sequence: BX648811
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000242208(uc003thq.3 uc003thr.3) ENST00000464515 ENST00000442711

    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate INHBA:
    hsa-miR-1233 hsa-miR-135b hsa-miR-205 hsa-miR-452* hsa-miR-135a
    SwitchGear 3'UTR luciferase reporter plasmidINHBA 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat INHBA
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: INHBA (NM_002192)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INHBA
    Primer
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    OriGene qPCR primer pairs and template standards for INHBA
    OriGene qSTAR qPCR primer pairs in human, mouse for INHBA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat INHBA
      QuantiTect SYBR Green Assays in human, mouse, rat INHBA
      QuantiFast Probe-based Assays in human, mouse, rat INHBA

    Additional mRNA sequence: 

    AF218018.1 AK222742.1 AK290584.1 BC007858.2 BX648811.1 D49743.1 J03634.1 M13436.1 
    X72498.1 

    9 DOTS entries:

    DT.91741308  DT.452433  DT.92030578  DT.92008315  DT.99942006  DT.100707716  DT.102831894  DT.40316631 
    DT.95173216 

    Selected AceView cDNA sequences (see all 110):

    BF000451 CA310336 BQ006749 CK825381 BP341643 BM554468 BQ003646 BM555692 
    AI905388 T29604 BF439415 CN480753 BQ574581 BQ267396 BC007858 CD367517 
    AA948385 AI738775 CD366041 AU139087 AI753619 AL599843 BU174063 BI058705 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    INHBA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCGTGGAGG
    INHBA Expression
    About this image


    INHBA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Oviduct
             Mature follicles
     
     Tooth
             Inner Enamel Epithelial Cells Dental Enamel
     
     Pancreas (Endocrine System)    fully expand to see all 3 entries
             Alpha Progenitor Cells Dorsal Pancreatic Bud
             Islets of Langerhans
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Testicular Interstitial Cells Testis Interstitium
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             Interzone Cells Stylopod Synovial Joint
             Stylopod Synovial Joint
    INHBA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    INHBA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.583348
        Pathway & Disease-focused RT2 Profiler PCR Arrays including INHBA (see all 8): 
              Growth Factors in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Common Cytokines in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for INHBA
    OriGene qSTAR qPCR primer pairs in human, mouse for INHBA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat INHBA
    QuantiTect SYBR Green Assays in human, mouse, rat INHBA
    QuantiFast Probe-based Assays in human, mouse, rat INHBA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INHBA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for INHBA gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Inhba1 , 5 inhibin beta-A1, 5 89.78(n)1
    94.58(a)1
      13 (5.85 cM)5
    163231  NM_008380.11  NP_032406.11 
     160144755 
    chicken
    (Gallus gallus)
    Aves INHBA1 inhibin, beta A 80.27(n)
    84.43(a)
      396361  NM_205396.1  NP_990727.1 
    lizard
    (Anolis carolinensis)
    Reptilia INHBA6
    Uncharacterized protein
    83(a)
    1 ↔ 1
    6(49715246-49731227)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia inhba1 inhibin, beta A 69.91(n)
    71.29(a)
      100038114  XM_002933406.1  XP_002933452.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AF475092.12   -- 75.89(n)   30072  AF475092.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Actbeta1 Activin-beta 46.98(n)
    35.91(a)
      43826  NM_143685.3  NP_651942.2 


    ENSEMBL Gene Tree for INHBA (if available)
    TreeFam Gene Tree for INHBA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for INHBA gene
    GDF112  MSTN2  INHBE2  TGFB22  INHBB2  TGFB32  INHBC2  TGFB12  
    2 SIMAP similar genes for INHBA using alignment to 2 protein entries:     INHBA_HUMAN (see all proteins):
    DKFZp686A06204    INHBB

    Find genes that share paralogs with INHBA           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for INHBA (see all 96)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1456635061,2
    --41728140(+) AATAAC/TAATTA 1 -- ds50010--------
    rs1506823431,2
    --41728251(+) GAAAAC/TACTTG 1 -- ds50010--------
    rs1512003701,2
    C--41728310(+) CGATT-/AAAAAA 1 -- ds50010--------
    rs1151240681,2
    C,F--41728654(+) ACACGA/CTTGTT 1 -- ut311Minor allele frequency- C:0.02WA 118
    rs1391040181,2
    C--41728701(+) ATGCC-/TGTGTG
            
    TGTGT
    1 -- cds10--------
    rs1399239801,2
    C--41728811(+) CCTGTC/GATGGG 1 -- ut310--------
    rs1825513481,2
    --41728877(+) CTGCAA/GACTAG 1 -- ut310--------
    rs1871233041,2
    --41728937(+) TACCCC/TGTTTA 1 -- ut310--------
    rs1919808351,2
    --41729022(+) TCTCTC/TTCACT 1 -- ut310--------
    rs1513042581,2
    C--41729111(+) TTTTG-/TTTTTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for INHBA (41724712 - 41742706 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for INHBA: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing INHBA
    DNA2.0 Custom Variant and Variant Library Synthesis for INHBA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 147290    OMIM disorders: --

    2 diseases for INHBA:    
    About MalaCards
    ovary adenocarcinoma    preterm premature rupture of the membranes


    Find genes that share disorders with INHBA           About GenesLikeMe

    Selected Novoseek inferred disease relationships for INHBA gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sex cord-stromal tumor 56.7 4 10747314 (3)
    erythroleukemia 46.2 3 1542647 (1), 1402687 (1), 2323849 (1)
    esophageal carcinoma 40.4 6 15355896 (1), 18695873 (1), 12469187 (1), 17909904 (1)
    epithelial tumor 20.8 1 10747314 (1)
    tumors 19.8 18 10747314 (3), 17609433 (2), 12206515 (2), 7829603 (1) (see all 9)
    pheochromocytoma 19.8 5 10810314 (3), 11344232 (1), 17680997 (1)
    adenoma 14.7 5 9691207 (1), 7599706 (1), 12821114 (1)
    goiter 14.6 2 11069203 (1), 12729472 (1)
    endometrial carcinoma 13.8 1 11585411 (1)
    carcinoma 11.5 4 19308293 (1), 9570994 (1), 17909904 (1), 12729472 (1)

    Genetic Association Database (GAD): INHBA
    Human Genome Epidemiology (HuGE) Navigator: INHBA (15 documents)

    Export disorders for INHBA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for INHBA gene, integrated from 10 sources (see all 288):
    (articles sorted by number of sources associating them with INHBA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variation in the inhibin pathway and risk of testicular germ cell tumors. (PubMed id 18413775)1, 4, 9 Purdue M.P....McGlynn K.A. (Cancer Res. 2008)
    2. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. (PubMed id 21102462)1, 4 Elks C.E....Murray A. (Nat. Genet. 2010)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    5. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)
    6. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    7. Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium. (PubMed id 20634197)1, 4 Canzian F....Feigelson H.S. (Hum. Mol. Genet. 2010)
    8. Genome-wide association study for colorectal cancer identifies risk polymorphisms in German familial cases and implicates MAPK signalling pathways in disease susceptibility. (PubMed id 20610541)1, 4 Lascorz J....Hemminki K. (Carcinogenesis 2010)
    9. Family-based analysis of candidate genes for polycystic ovary syndrome. (PubMed id 20200332)1, 4 Ewens K.G....Spielman R.S. (J. Clin. Endocrinol. Metab. 2010)
    10. Quantitative trait loci predicting circulating sex steroid hormones in men from the NCI-Breast and Prostate Cancer Cohort Consortium (BPC3). (PubMed id 19574343)1, 4 Ahn J....Hayes R.B. (Hum. Mol. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3624 HGNC: 6066 AceView: INHBA Ensembl:ENSG00000122641 euGenes: HUgn3624
    ECgene: INHBA Kegg: 3624 H-InvDB: INHBA

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for INHBA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for INHBA Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Activin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for INHBA gene:
    Search GeneIP for patents involving INHBA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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